ILK

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein with a kinase-like domain and four ankyrin-like repeats. The encoded protein associates at the cell membrane with the cytoplasmic domain of beta integrins, where it regulates integrin-mediated signal transduction. Activity of this protein is important in the epithelial to mesenchymal transition, and over-expression of this gene is implicated in tumor growth and metastasis. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1Golgi transport vesicle coating (GO:0048200)4.65087392
2COPI coating of Golgi vesicle (GO:0048205)4.65087392
3protein maturation by protein folding (GO:0022417)4.50630475
4* extracellular fibril organization (GO:0043206)4.11398554
5thrombin receptor signaling pathway (GO:0070493)4.07251176
6protein neddylation (GO:0045116)4.00063765
7positive regulation of receptor recycling (GO:0001921)3.78760306
8chondrocyte proliferation (GO:0035988)3.78258083
9negative regulation of homotypic cell-cell adhesion (GO:0034111)3.66556364
10negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)3.56624373
11positive regulation of Rho protein signal transduction (GO:0035025)3.53755516
12maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.50721986
13barbed-end actin filament capping (GO:0051016)3.48739605
14negative regulation of phagocytosis (GO:0050765)3.48556470
15protein heterotrimerization (GO:0070208)3.47021196
16collagen fibril organization (GO:0030199)3.42197949
17positive regulation of macrophage differentiation (GO:0045651)3.41242089
18regulation of platelet aggregation (GO:0090330)3.39463574
19protein retention in ER lumen (GO:0006621)3.39126459
20negative regulation of fatty acid transport (GO:2000192)3.32716178
21positive regulation of mitochondrial calcium ion concentration (GO:0051561)3.32220973
22positive regulation of actin filament depolymerization (GO:0030836)3.26498367
23endodermal cell differentiation (GO:0035987)3.23715835
24pinocytosis (GO:0006907)3.22812062
25negative regulation of platelet activation (GO:0010544)3.20385254
26regulation of platelet activation (GO:0010543)3.17000079
27Arp2/3 complex-mediated actin nucleation (GO:0034314)3.13213982
28negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.13129804
29basement membrane organization (GO:0071711)3.11078356
30adenosine receptor signaling pathway (GO:0001973)3.08740146
31type B pancreatic cell proliferation (GO:0044342)3.06724224
32antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.05659522
33antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.05659522
34keratan sulfate catabolic process (GO:0042340)3.04183884
35regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.03676164
36* platelet aggregation (GO:0070527)3.02032197
37cell adhesion mediated by integrin (GO:0033627)3.01917011
38epithelial cell-cell adhesion (GO:0090136)3.01299877
39regulation of homotypic cell-cell adhesion (GO:0034110)2.97916011
40leukocyte migration involved in inflammatory response (GO:0002523)2.94996864
41negative regulation of nitric-oxide synthase activity (GO:0051001)2.93431535
42membrane invagination (GO:0010324)2.93126092
43negative regulation of protein localization to cell surface (GO:2000009)2.92745997
44positive regulation of endothelial cell differentiation (GO:0045603)2.92169273
45negative regulation of protein localization to plasma membrane (GO:1903077)2.89722042
46regulation of receptor recycling (GO:0001919)2.89367143
47antigen processing and presentation of endogenous antigen (GO:0019883)2.86262214
48dermatan sulfate metabolic process (GO:0030205)2.86219731
49protein localization to endosome (GO:0036010)2.86135838
50mesodermal cell differentiation (GO:0048333)2.85521970
51positive regulation of natural killer cell differentiation (GO:0032825)2.79935065
52beta-amyloid metabolic process (GO:0050435)2.77507525
53cell proliferation involved in metanephros development (GO:0072203)2.77286220
54sequestering of extracellular ligand from receptor (GO:0035581)2.75890857
55negative regulation of stress fiber assembly (GO:0051497)2.74706588
56dermatan sulfate biosynthetic process (GO:0030208)2.74699512
57antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.74615049
58muscle filament sliding (GO:0030049)2.74239605
59actin-myosin filament sliding (GO:0033275)2.74239605
60positive regulation of extrinsic apoptotic signaling pathway in absence of ligand (GO:2001241)2.72652580
61positive regulation of epithelial to mesenchymal transition (GO:0010718)2.72363718
62fibrinolysis (GO:0042730)2.72082311
63regulation of integrin activation (GO:0033623)2.71902162
64vascular endothelial growth factor signaling pathway (GO:0038084)2.71474189
65wound healing, spreading of epidermal cells (GO:0035313)2.70635739
66antigen processing and presentation via MHC class Ib (GO:0002475)2.69501333
67angiogenesis involved in wound healing (GO:0060055)2.69416283
68response to interferon-alpha (GO:0035455)2.67725882
69sequestering of actin monomers (GO:0042989)2.67421362
70lipoxygenase pathway (GO:0019372)2.65607205
71negative regulation of release of cytochrome c from mitochondria (GO:0090201)2.64671249
72regulation of integrin-mediated signaling pathway (GO:2001044)2.64325656
73skin morphogenesis (GO:0043589)2.64155484
74platelet activation (GO:0030168)2.63648663
75regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.63610106
76neutrophil activation involved in immune response (GO:0002283)2.62675054
77response to interferon-beta (GO:0035456)2.62560150
78collagen metabolic process (GO:0032963)2.61835790
79response to gravity (GO:0009629)2.61783895
80positive regulation of interleukin-8 secretion (GO:2000484)2.61411062
81positive regulation of endothelial cell apoptotic process (GO:2000353)2.60795548
82membrane raft organization (GO:0031579)2.60773740
83hyaluronan catabolic process (GO:0030214)2.60280601
84positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.60043321
85negative regulation of macrophage derived foam cell differentiation (GO:0010745)2.59826701
86apoptotic cell clearance (GO:0043277)2.59388068
87peptide catabolic process (GO:0043171)2.58809981
88signal peptide processing (GO:0006465)2.57711538
89wound healing, spreading of cells (GO:0044319)2.56711664
90endothelium development (GO:0003158)2.55833296
91regulation of protein heterodimerization activity (GO:0043497)2.55383588
92positive regulation of blood vessel endothelial cell migration (GO:0043536)2.54487848
93blood coagulation, intrinsic pathway (GO:0007597)2.54181163
94polyamine biosynthetic process (GO:0006596)2.53976695
95positive regulation of blood coagulation (GO:0030194)2.53267210
96positive regulation of hemostasis (GO:1900048)2.53267210
97regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.52078311
98UV protection (GO:0009650)2.47368467
99sarcomere organization (GO:0045214)2.46929164
100collagen catabolic process (GO:0030574)2.46868677
101endosome to melanosome transport (GO:0035646)2.45899024
102endosome to pigment granule transport (GO:0043485)2.45899024
103negative regulation of thymocyte apoptotic process (GO:0070244)2.45017610
104positive regulation of coagulation (GO:0050820)2.44742998
105triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.44022245
106negative regulation of nitric oxide biosynthetic process (GO:0045019)2.43029472
107cell migration involved in heart development (GO:0060973)2.42946854
108heart contraction (GO:0060047)2.42833752
109heart process (GO:0003015)2.42833752
110* fibril organization (GO:0097435)2.42493821
111morphogenesis of an endothelium (GO:0003159)2.42066713
112endothelial tube morphogenesis (GO:0061154)2.42066713
113positive regulation of substrate adhesion-dependent cell spreading (GO:1900026)2.39721056
114cyclooxygenase pathway (GO:0019371)2.39717648
115fusion of sperm to egg plasma membrane (GO:0007342)2.39647235
116positive regulation of transforming growth factor beta receptor signaling pathway (GO:0030511)2.39321898
117protein localization to cell surface (GO:0034394)2.38324630
118muscle cell migration (GO:0014812)2.36903689
119multicellular organismal macromolecule metabolic process (GO:0044259)2.36835701
120stress fiber assembly (GO:0043149)2.36473140
121phagocytosis, engulfment (GO:0006911)2.35205830
122neutrophil activation (GO:0042119)2.35049468
123protein targeting to plasma membrane (GO:0072661)2.33384864
124regulation of macrophage cytokine production (GO:0010935)2.33143650
125regulation of tight junction assembly (GO:2000810)2.32294605
126actin-mediated cell contraction (GO:0070252)2.32227116
127hypotonic response (GO:0006971)2.31956122
128T cell apoptotic process (GO:0070231)2.31158835
129cortical actin cytoskeleton organization (GO:0030866)2.31009324
130negative regulation of coagulation (GO:0050819)2.30993361
131regulation of metalloenzyme activity (GO:0048552)2.30824085
132blood vessel maturation (GO:0001955)2.30498066
133extracellular matrix disassembly (GO:0022617)2.30093268
134regulation of coagulation (GO:0050818)2.29871020
135regulation of mononuclear cell migration (GO:0071675)2.29315350
136cellular response to vitamin (GO:0071295)2.29028714
137regulation of hemostasis (GO:1900046)2.28628577
138regulation of blood coagulation (GO:0030193)2.28628577
139actin filament depolymerization (GO:0030042)2.27892008
140renal filtration (GO:0097205)2.27459078
141cellular response to zinc ion (GO:0071294)2.26152840
142purine-containing compound salvage (GO:0043101)2.25518655
143cell proliferation involved in kidney development (GO:0072111)2.24972632
144atrioventricular valve morphogenesis (GO:0003181)2.23289612
145multicellular organismal catabolic process (GO:0044243)2.23134724
146cardiac myofibril assembly (GO:0055003)2.23097756
147cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.23059933
148phagocytosis, recognition (GO:0006910)2.21704653
149endocardial cushion development (GO:0003197)2.21670198
150definitive hemopoiesis (GO:0060216)2.21533954
151multicellular organismal metabolic process (GO:0044236)2.21031184
152platelet degranulation (GO:0002576)2.20638954
153glomerular basement membrane development (GO:0032836)2.20552628
154sequestering of metal ion (GO:0051238)2.19186587
155* substrate adhesion-dependent cell spreading (GO:0034446)2.19085557
156substrate-dependent cell migration (GO:0006929)2.18575470
157positive regulation of lamellipodium assembly (GO:0010592)2.18375273
158glomerular filtration (GO:0003094)2.15685033
159positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.15018432
160response to fluid shear stress (GO:0034405)2.14225924
161platelet dense granule organization (GO:0060155)2.13992703
162regulation of dendritic cell antigen processing and presentation (GO:0002604)2.13693944
163* homotypic cell-cell adhesion (GO:0034109)2.13255632
164positive regulation of lamellipodium organization (GO:1902745)2.10777102

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RARG_19884340_ChIP-ChIP_MEFs_Mouse3.47845246
2TRIM28_21343339_ChIP-Seq_HEK293_Human3.46732342
3EGR1_19374776_ChIP-ChIP_THP-1_Human3.05619459
4IRF8_22096565_ChIP-ChIP_GC-B_Human2.97223029
5FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.69192328
6PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.68820586
7EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.65521894
8CLOCK_20551151_ChIP-Seq_293T_Human2.54440859
9TP63_17297297_ChIP-ChIP_HaCaT_Human2.54170160
10NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.40106235
11MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.23084192
12NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.14959363
13STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.14460705
14MYB_21317192_ChIP-Seq_ERMYB_Mouse2.11790879
15SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human2.11111239
16TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.10790798
17IRF8_21731497_ChIP-ChIP_J774_Mouse2.10631133
18* ELK3_25401928_ChIP-Seq_HUVEC_Human2.06732968
19Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.02349436
20PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.99564630
21TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.97564335
22E2F7_22180533_ChIP-Seq_HELA_Human1.96723419
23CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.95602084
24SMAD_19615063_ChIP-ChIP_OVARY_Human1.95222371
25* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.93948951
26TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.88234566
27RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.82748626
28RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.80416673
29GATA1_22025678_ChIP-Seq_K562_Human1.74838678
30TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.73765526
31NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.68924849
32* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.68096559
33ELF1_17652178_ChIP-ChIP_JURKAT_Human1.67875545
34JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.67269375
35SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.66593089
36IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.66436495
37SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.61626030
38VDR_21846776_ChIP-Seq_THP-1_Human1.61388226
39STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.61124619
40BP1_19119308_ChIP-ChIP_Hs578T_Human1.60998063
41* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.58282937
42SRY_22984422_ChIP-ChIP_TESTIS_Rat1.57724088
43GATA2_21666600_ChIP-Seq_HMVEC_Human1.56970973
44NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.56061282
45ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.55607829
46FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.55237097
47TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.53554212
48SCL_19346495_ChIP-Seq_HPC-7_Human1.52724191
49POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.52618647
50MAF_26560356_Chip-Seq_TH1_Human1.52271042
51IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.49963135
52STAT4_19710469_ChIP-ChIP_TH1__Mouse1.46876608
53MYC_22102868_ChIP-Seq_BL_Human1.44978442
54VDR_24763502_ChIP-Seq_THP-1_Human1.44308303
55* SPI1_23547873_ChIP-Seq_NB4_Human1.43375217
56IRF8_27001747_Chip-Seq_BMDM_Mouse1.42114076
57SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.42049074
58HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.41493308
59BRD4_27068464_Chip-Seq_AML-cells_Mouse1.38195459
60* SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.36123239
61HIF1A_21447827_ChIP-Seq_MCF-7_Human1.34959103
62GATA1_19941827_ChIP-Seq_MEL_Mouse1.33649657
63MYB_26560356_Chip-Seq_TH2_Human1.32789002
64ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.32419802
65MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.29457063
66SMC1_22415368_ChIP-Seq_MEFs_Mouse1.27975797
67GATA1_22383799_ChIP-Seq_G1ME_Mouse1.27533567
68* RUNX1_22412390_ChIP-Seq_EML_Mouse1.24003964
69SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.22238198
70CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.21835812
71NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.21831528
72GATA1_19941826_ChIP-Seq_K562_Human1.20859003
73CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.20747373
74PPAR_26484153_Chip-Seq_NCI-H1993_Human1.20643838
75UTX_26944678_Chip-Seq_JUKART_Human1.19973088
76TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.19745353
77GATA4_21415370_ChIP-Seq_HL-1_Mouse1.19249180
78SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.19014871
79SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.19014871
80KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.18044523
81WT1_19549856_ChIP-ChIP_CCG9911_Human1.17293318
82RXR_22158963_ChIP-Seq_LIVER_Mouse1.16665499
83BRD4_25478319_ChIP-Seq_HGPS_Human1.15703696
84PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.14207065
85CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.13941074
86STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.13457998
87SPI1_23127762_ChIP-Seq_K562_Human1.13436129
88* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.13259789
89ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.11115135
90CJUN_26792858_Chip-Seq_BT549_Human1.09529869
91CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.09002185
92MYB_26560356_Chip-Seq_TH1_Human1.08955396
93SRF_21415370_ChIP-Seq_HL-1_Mouse1.08887873
94TFEB_21752829_ChIP-Seq_HELA_Human1.08704294
95CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.07662659
96SOX2_20726797_ChIP-Seq_SW620_Human1.07374726
97MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.07037166
98LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.05743328
99KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.04795078
100NELFA_20434984_ChIP-Seq_ESCs_Mouse1.04627023
101PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.04425511
102CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.04411302
103SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.03683060
104JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.03399490
105TBX20_22080862_ChIP-Seq_HEART_Mouse1.03385668
106TBX20_22328084_ChIP-Seq_HEART_Mouse1.03385668
107* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.03256009
108SMC3_22415368_ChIP-Seq_MEFs_Mouse1.03060700
109GATA2_19941826_ChIP-Seq_K562_Human1.02795734
110SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.02291622
111CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.02276105
112RACK7_27058665_Chip-Seq_MCF-7_Human1.02233695
113THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.02013664
114LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.01928120
115GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.01741324
116NRF2_20460467_ChIP-Seq_MEFs_Mouse1.01581661
117NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.01581661
118CSB_26484114_Chip-Seq_FIBROBLAST_Human1.01007333
119ERG_20887958_ChIP-Seq_HPC-7_Mouse1.00696579
120CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.00281203
121P63_26484246_Chip-Seq_KERATINOCYTES_Human0.99389480
122RUNX_20019798_ChIP-Seq_JUKART_Human0.97712740
123ATF3_27146783_Chip-Seq_COLON_Human0.97649320
124GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.97107957
125ESR2_21235772_ChIP-Seq_MCF-7_Human0.95934706
126LXR_22292898_ChIP-Seq_THP-1_Human0.94890598
127HOXB4_20404135_ChIP-ChIP_EML_Mouse0.94666412
128SALL4_18804426_ChIP-ChIP_XEN_Mouse0.94132493
129E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.93647720
130UBF1/2_26484160_Chip-Seq_HMECs_Human0.93395089

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen5.51777981
2MP0003279_aneurysm3.63123188
3MP0006054_spinal_hemorrhage3.47501967
4MP0005503_abnormal_tendon_morphology3.22086442
5MP0005275_abnormal_skin_tensile3.03780246
6MP0003705_abnormal_hypodermis_morpholog2.48805997
7MP0008004_abnormal_stomach_pH2.45935170
8MP0001958_emphysema2.35543936
9* MP0003566_abnormal_cell_adhesion2.28796523
10MP0009840_abnormal_foam_cell2.19697291
11MP0005257_abnormal_intraocular_pressure2.13557177
12MP0010368_abnormal_lymphatic_system2.10059745
13MP0003191_abnormal_cellular_cholesterol2.05842238
14MP0009384_cardiac_valve_regurgitation1.96730416
15MP0005023_abnormal_wound_healing1.90486316
16MP0004084_abnormal_cardiac_muscle1.78635408
17* MP0004272_abnormal_basement_membrane1.73412379
18MP0005165_increased_susceptibility_to1.68776806
19MP0001835_abnormal_antigen_presentation1.68674009
20MP0005058_abnormal_lysosome_morphology1.66436061
21MP0000343_altered_response_to1.64469375
22MP0001849_ear_inflammation1.62635180
23MP0000685_abnormal_immune_system1.59775781
24MP0000767_abnormal_smooth_muscle1.58997753
25MP0008260_abnormal_autophagy1.57009055
26MP0002933_joint_inflammation1.47706611
27MP0001533_abnormal_skeleton_physiology1.46696926
28MP0001542_abnormal_bone_strength1.46254539
29MP0001879_abnormal_lymphatic_vessel1.45997146
30MP0000751_myopathy1.45484598
31MP0002396_abnormal_hematopoietic_system1.44536902
32MP0003091_abnormal_cell_migration1.43476967
33MP0002877_abnormal_melanocyte_morpholog1.41084002
34MP0000749_muscle_degeneration1.39728960
35MP0005508_abnormal_skeleton_morphology1.38846743
36MP0003436_decreased_susceptibility_to1.37239939
37MP0010352_gastrointestinal_tract_polyps1.35167433
38MP0000465_gastrointestinal_hemorrhage1.34511697
39MP0009785_altered_susceptibility_to1.34432899
40MP0002166_altered_tumor_susceptibility1.32234168
41MP0005390_skeleton_phenotype1.29886545
42MP0004808_abnormal_hematopoietic_stem1.29691944
43MP0000858_altered_metastatic_potential1.29292267
44MP0005595_abnormal_vascular_smooth1.25063083
45MP0005623_abnormal_meninges_morphology1.23537665
46MP0003075_altered_response_to1.22558952
47MP0002148_abnormal_hypersensitivity_rea1.20884182
48MP0002419_abnormal_innate_immunity1.19536088
49MP0003806_abnormal_nucleotide_metabolis1.17474353
50MP0010030_abnormal_orbit_morphology1.17361809
51MP0005464_abnormal_platelet_physiology1.16914077
52MP0003300_gastrointestinal_ulcer1.15556401
53MP0003828_pulmonary_edema1.15021748
54MP0001545_abnormal_hematopoietic_system1.11982743
55MP0005397_hematopoietic_system_phenotyp1.11982743
56MP0001243_abnormal_dermal_layer1.10044011
57MP0000733_abnormal_muscle_development1.06800264
58MP0002128_abnormal_blood_circulation1.06668943
59MP0008007_abnormal_cellular_replicative1.06572036
60MP0003724_increased_susceptibility_to1.06207800
61MP0010630_abnormal_cardiac_muscle1.05922621
62MP0005083_abnormal_biliary_tract1.05390168
63MP0002060_abnormal_skin_morphology1.05213195
64MP0003172_abnormal_lysosome_physiology1.04909435
65MP0000013_abnormal_adipose_tissue1.03216194
66MP0002998_abnormal_bone_remodeling1.02530742
67MP0002295_abnormal_pulmonary_circulatio1.02219815
68MP0002405_respiratory_system_inflammati1.01262334
69MP0008775_abnormal_heart_ventricle0.99895309
70MP0000230_abnormal_systemic_arterial0.99563262
71MP0005385_cardiovascular_system_phenoty0.99334764
72MP0001544_abnormal_cardiovascular_syste0.99334764
73MP0003795_abnormal_bone_structure0.97853063
74MP0002452_abnormal_antigen_presenting0.97665982
75MP0005000_abnormal_immune_tolerance0.97149863
76MP0005671_abnormal_response_to0.97119492
77MP0003448_altered_tumor_morphology0.96264250
78MP0005025_abnormal_response_to0.95505201
79MP0002972_abnormal_cardiac_muscle0.95422893
80MP0000249_abnormal_blood_vessel0.93677143
81MP0005330_cardiomyopathy0.93341559
82MP0001614_abnormal_blood_vessel0.92574501
83MP0002006_tumorigenesis0.92551187
84MP0005620_abnormal_muscle_contractility0.91577102
85MP0009053_abnormal_anal_canal0.91215054
86MP0009278_abnormal_bone_marrow0.90338350
87MP0009764_decreased_sensitivity_to0.90240481
88MP0003186_abnormal_redox_activity0.90066838
89MP0009333_abnormal_splenocyte_physiolog0.89939051
90MP0005164_abnormal_response_to0.89500477
91MP0003303_peritoneal_inflammation0.89480022
92MP0004087_abnormal_muscle_fiber0.89368625
93MP0006138_congestive_heart_failure0.88530913
94MP0001853_heart_inflammation0.87856550
95MP0005084_abnormal_gallbladder_morpholo0.87491230
96MP0005166_decreased_susceptibility_to0.86347174
97MP0005171_absent_coat_pigmentation0.85620700
98MP0009780_abnormal_chondrocyte_physiolo0.85228819
99MP0009763_increased_sensitivity_to0.85076612
100MP0002420_abnormal_adaptive_immunity0.84801045
101MP0001915_intracranial_hemorrhage0.83924877
102MP0001819_abnormal_immune_cell0.83052371
103MP0001851_eye_inflammation0.82964038
104MP0010155_abnormal_intestine_physiology0.82483432
105MP0005387_immune_system_phenotype0.82256771
106MP0001790_abnormal_immune_system0.82256771
107MP0003385_abnormal_body_wall0.80958955
108* MP0002113_abnormal_skeleton_development0.79911250
109MP0004883_abnormal_blood_vessel0.79798045
110MP0003950_abnormal_plasma_membrane0.79190593
111MP0000750_abnormal_muscle_regeneration0.78924900
112MP0004510_myositis0.77715947
113* MP0001175_abnormal_lung_morphology0.77230374
114MP0004036_abnormal_muscle_relaxation0.77140117
115MP0001348_abnormal_lacrimal_gland0.76870279
116MP0003943_abnormal_hepatobiliary_system0.76562789
117MP0004947_skin_inflammation0.76355208
118MP0006082_CNS_inflammation0.76240270
119MP0002398_abnormal_bone_marrow0.76006406
120MP0001845_abnormal_inflammatory_respons0.74981739
121MP0002089_abnormal_postnatal_growth/wei0.74508531
122MP0002896_abnormal_bone_mineralization0.74290899
123MP0002925_abnormal_cardiovascular_devel0.74290842
124MP0002723_abnormal_immune_serum0.73911732
125MP0003763_abnormal_thymus_physiology0.73827260
126MP0002132_abnormal_respiratory_system0.69727511
127MP0010386_abnormal_urinary_bladder0.69483893
128MP0005167_abnormal_blood-brain_barrier0.66310484

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)5.95512133
2Increased mean platelet volume (HP:0011877)5.43643503
3Menorrhagia (HP:0000132)5.34257282
4Abnormal platelet volume (HP:0011876)5.13616669
5Premature rupture of membranes (HP:0001788)4.85319749
6Prolonged bleeding time (HP:0003010)4.77965319
7Aortic dissection (HP:0002647)4.63259538
8Purpura (HP:0000979)4.55686486
9Aortic aneurysm (HP:0004942)4.41033285
10Cervical subluxation (HP:0003308)3.83933789
11Cerebral aneurysm (HP:0004944)3.73930195
12Epistaxis (HP:0000421)3.72161894
13Vertebral compression fractures (HP:0002953)3.70025868
14Ankle contracture (HP:0006466)3.36542693
15Biconcave vertebral bodies (HP:0004586)3.35513580
16Impaired platelet aggregation (HP:0003540)3.23893835
17Abnormal platelet function (HP:0011869)3.23893835
18Gingival bleeding (HP:0000225)3.13931344
19Hyperlipoproteinemia (HP:0010980)3.13739408
20Dilatation of the ascending aorta (HP:0005111)3.08860169
21Soft skin (HP:0000977)2.98176500
22Peritonitis (HP:0002586)2.98060017
23Beaking of vertebral bodies (HP:0004568)2.88886111
24Broad metatarsal (HP:0001783)2.86900073
25Shallow orbits (HP:0000586)2.82232762
26Distal lower limb muscle weakness (HP:0009053)2.79054194
27Nonimmune hydrops fetalis (HP:0001790)2.76733968
28Type 1 muscle fiber predominance (HP:0003803)2.74246232
29Blue sclerae (HP:0000592)2.72680164
30Myocardial infarction (HP:0001658)2.71000032
31Hepatosplenomegaly (HP:0001433)2.70300391
32Spondylolisthesis (HP:0003302)2.62447327
33Increased variability in muscle fiber diameter (HP:0003557)2.62034151
34Neonatal short-limb short stature (HP:0008921)2.61069250
35Abnormality of the acetabulum (HP:0003170)2.59431306
36Wormian bones (HP:0002645)2.58323707
37Distal lower limb amyotrophy (HP:0008944)2.58249190
38Vascular tortuosity (HP:0004948)2.55623052
39Abnormality of dentin (HP:0010299)2.52110694
40Osteolytic defects of the hand bones (HP:0009699)2.51083904
41Osteolytic defects of the phalanges of the hand (HP:0009771)2.51083904
42Spinal rigidity (HP:0003306)2.49822005
43Bladder diverticulum (HP:0000015)2.46964562
44Spontaneous hematomas (HP:0007420)2.46336606
45Upper limb muscle weakness (HP:0003484)2.43619206
46Bruising susceptibility (HP:0000978)2.40051571
47Abnormality of macrophages (HP:0004311)2.39227441
48Atrophic scars (HP:0001075)2.36224927
49Broad face (HP:0000283)2.35389298
50Joint stiffness (HP:0001387)2.34047840
51Arterial tortuosity (HP:0005116)2.32070667
52Mitral stenosis (HP:0001718)2.30823996
53Elevated erythrocyte sedimentation rate (HP:0003565)2.22085272
54Abnormal gallbladder physiology (HP:0012438)2.21739919
55Cholecystitis (HP:0001082)2.21739919
56Fragile skin (HP:0001030)2.19974429
57Increased connective tissue (HP:0009025)2.18640060
58Vacuolated lymphocytes (HP:0001922)2.18522142
59Abnormal pupillary function (HP:0007686)2.17445962
60Syringomyelia (HP:0003396)2.16108234
61Spinal cord lesions (HP:0100561)2.16108234
62Axonal loss (HP:0003447)2.14802142
63Conjunctival telangiectasia (HP:0000524)2.13986107
64Reduced subcutaneous adipose tissue (HP:0003758)2.12447634
65Increased density of long bones (HP:0006392)2.12333354
66Myositis (HP:0100614)2.12211320
67Platyspondyly (HP:0000926)2.11991544
68Aneurysm (HP:0002617)2.11448298
69Distal upper limb amyotrophy (HP:0007149)2.11293077
70Upper limb amyotrophy (HP:0009129)2.11293077
71Aortic regurgitation (HP:0001659)2.10813393
72Thin bony cortex (HP:0002753)2.10773282
73Lipoatrophy (HP:0100578)2.10530317
74Abnormal delivery (HP:0001787)2.10355711
75Mesomelia (HP:0003027)2.10308854
76Mitral regurgitation (HP:0001653)2.10078140
77Flat acetabular roof (HP:0003180)2.08991812
78Abnormality of the Achilles tendon (HP:0005109)2.07248242
79Abnormality of the calcaneus (HP:0008364)2.05296357
80Abnormality of glycosphingolipid metabolism (HP:0004343)2.05138480
81Abnormality of glycolipid metabolism (HP:0010969)2.05138480
82Abnormality of liposaccharide metabolism (HP:0010968)2.05138480
83Thrombocytosis (HP:0001894)2.02480878
84Cardiovascular calcification (HP:0011915)2.01107685
85Mitral valve prolapse (HP:0001634)2.00920900
86Follicular hyperkeratosis (HP:0007502)2.00238519
87Radial bowing (HP:0002986)2.00091164
88Abnormality of the vasculature of the conjunctiva (HP:0008054)1.99658218
89Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.97357801
90Short 4th metacarpal (HP:0010044)1.97357801
91Camptodactyly of toe (HP:0001836)1.97155510
92Mesangial abnormality (HP:0001966)1.96312930
93Generalized amyotrophy (HP:0003700)1.93516017
94Xanthomatosis (HP:0000991)1.92797566
95Hypertriglyceridemia (HP:0002155)1.92493921
96Nemaline bodies (HP:0003798)1.92437561
97Dysostosis multiplex (HP:0000943)1.92313456
98Asymmetry of the thorax (HP:0001555)1.91418692
99Increased IgM level (HP:0003496)1.87847578
100Cupped ribs (HP:0000887)1.87636897
101Amyloidosis (HP:0011034)1.86860220
102Polycythemia (HP:0001901)1.83231052
103Abnormality of the common coagulation pathway (HP:0010990)1.83046520
104Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.82895180
105Eczematoid dermatitis (HP:0000976)1.82161846
106Tetraparesis (HP:0002273)1.82128723
107Gastrointestinal dysmotility (HP:0002579)1.81752525
108Flexion contracture of toe (HP:0005830)1.81735825
109Joint contractures involving the joints of the feet (HP:0100492)1.81735825
110Systemic lupus erythematosus (HP:0002725)1.80578382
111Nuclear cataract (HP:0100018)1.80203912
112Lower limb amyotrophy (HP:0007210)1.79843883
113Ectopia lentis (HP:0001083)1.79509651
114Genu recurvatum (HP:0002816)1.79443516
115Ovoid vertebral bodies (HP:0003300)1.79299082
116Coxa vara (HP:0002812)1.78523477
117Bicuspid aortic valve (HP:0001647)1.78125684
118Achilles tendon contracture (HP:0001771)1.77972153
119Lumbar hyperlordosis (HP:0002938)1.77623989
120Vertebral hypoplasia (HP:0008417)1.77403638
121Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.77403638
122Recurrent abscess formation (HP:0002722)1.76415193
123Difficulty climbing stairs (HP:0003551)1.76161454
124Centrally nucleated skeletal muscle fibers (HP:0003687)1.75412173
125Elbow flexion contracture (HP:0002987)1.74399514
126Aortic valve stenosis (HP:0001650)1.73539423
127Mucopolysacchariduria (HP:0008155)1.73353228
128Urinary glycosaminoglycan excretion (HP:0003541)1.73353228
129Increased cerebral lipofuscin (HP:0011813)1.73243607
130Selective tooth agenesis (HP:0001592)1.73010302
131Wrist flexion contracture (HP:0001239)1.72607919
132Striae distensae (HP:0001065)1.72258860
133Scapular winging (HP:0003691)1.71175984
134Short nail (HP:0001799)1.71089124
135Asymmetric septal hypertrophy (HP:0001670)1.71025625
136Slender build (HP:0001533)1.70389094
137Joint hemorrhage (HP:0005261)1.69386638
138Ulnar bowing (HP:0003031)1.69333475
139Broad palm (HP:0001169)1.69009975
140Abnormality of polysaccharide metabolism (HP:0011012)1.68949681
141Abnormality of glycosaminoglycan metabolism (HP:0004371)1.68949681
142Abnormality of mucopolysaccharide metabolism (HP:0011020)1.68949681
143Bowel diverticulosis (HP:0005222)1.68676537
144Hand muscle atrophy (HP:0009130)1.68386461
145Bowed forearm bones (HP:0003956)1.68191389
146Bowing of the arm (HP:0006488)1.68191389
147Petechiae (HP:0000967)1.67383802
148Breech presentation (HP:0001623)1.67342196
149Mildly elevated creatine phosphokinase (HP:0008180)1.66082673
150Increased neuronal autofluorescent lipopigment (HP:0002074)1.65184669
151Osteopenia (HP:0000938)1.63640726
152Limb-girdle muscle atrophy (HP:0003797)1.62027869
153Hypoplasia of the iris (HP:0007676)1.62000723
154Joint laxity (HP:0001388)1.61297143
155Abnormality of skeletal muscle fiber size (HP:0012084)1.60945349
156Chondrocalcinosis (HP:0000934)1.60333503
157Abnormality of the odontoid process (HP:0003310)1.59737821
158Hypoplasia of the odontoid process (HP:0003311)1.58643196

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB33.74859715
2MYLK3.14601901
3TTN2.87099413
4ERN12.68826376
5TESK12.66229423
6PKN22.49656091
7TGFBR22.21578648
8MAP3K122.20098959
9KDR2.08366463
10LIMK12.06633390
11MST42.05626919
12BMX2.04361604
13PIM22.03001904
14KIT1.97202339
15TRPM71.88982045
16FLT31.87215617
17TIE11.81421406
18ARAF1.78544396
19LRRK21.77048895
20TAOK31.76172279
21TESK21.73954445
22NEK91.69973415
23JAK31.67912185
24MAP2K31.60964904
25TBK11.59574502
26RIPK41.49852609
27TGFBR11.49811713
28EPHB21.46503887
29PIK3CG1.43943107
30EPHA31.41623045
31EPHB11.41380845
32STK101.38187282
33PDGFRA1.37448503
34MAPKAPK31.37087157
35ZAP701.36702798
36PAK41.35424365
37TYK21.29250759
38PTK61.26892576
39DMPK1.25469254
40MAP4K11.25432792
41FGFR41.18374286
42VRK21.17964488
43ERBB31.17470709
44EEF2K1.15960845
45GRK51.15943887
46RPS6KA41.15911501
47PAK21.15628243
48IRAK31.11240248
49ZAK1.10121029
50MAP3K31.05786779
51PIK3CA1.03435017
52SIK11.02970394
53BTK1.00812293
54FER1.00777451
55NME21.00426397
56PTK20.98852161
57FGR0.95889813
58GRK70.95327878
59BLK0.94921319
60SCYL20.92667272
61PRKG20.92445240
62BRSK20.90624541
63ABL20.89113320
64RIPK10.88399623
65NUAK10.88390788
66PRKD20.87533448
67ROCK20.86217715
68DDR20.86150297
69DAPK10.85281509
70EIF2AK10.83797497
71MAP3K140.82927230
72PTK2B0.82764682
73SIK30.82609258
74* ILK0.81989244
75OBSCN0.81151102
76IRAK40.80652782
77ERBB40.77914383
78PRKD10.77892680
79JAK10.75911645
80GRK60.74241859
81BCKDK0.73917086
82TEC0.73595169
83STK240.72047245
84MAP3K50.71161983
85BMPR20.70470024
86EPHA20.70272264
87IKBKE0.70249735
88ROCK10.67749233
89MOS0.67085375
90CDC42BPA0.65651866
91CSF1R0.65325814
92MAP3K110.65237586
93MAPKAPK20.62035001
94ADRBK10.60899357
95BUB10.56446650
96ITK0.55708052
97IKBKB0.54812058
98TXK0.53481470
99HCK0.53459381
100STK380.51968532
101PDK20.51931641
102PLK20.51915601
103LMTK20.50759150
104MET0.50228803
105CDK80.50097760
106MAP3K80.49682434
107RPS6KA60.49388162
108PDGFRB0.48401739
109FES0.47741231
110DAPK30.47205611
111CHUK0.46736197
112SYK0.46656724
113STK30.45807804
114MARK30.45332135
115MAP3K100.45324160
116GSK3A0.44935216
117MATK0.44252399
118MUSK0.43998688
119FGFR10.43367458
120PRKCH0.42944407
121RPS6KB20.42460870
122RPS6KC10.39942346
123RPS6KL10.39942346
124CLK10.39936433
125RPS6KA20.39769165
126ACVR1B0.39515220
127CDK140.39145190
128MAP3K10.38694473
129CSK0.38298352
130PIM10.38035576
131TAOK20.37624505
132FGFR30.36746996
133CAMK2G0.36610185
134SRC0.36549211
135BRSK10.36193667
136* PAK10.33706854
137NTRK10.29727629
138STK40.27272805
139PAK30.26422501

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.53610358
2* Bacterial invasion of epithelial cells_Homo sapiens_hsa051002.36002807
3ECM-receptor interaction_Homo sapiens_hsa045122.20961489
4* Focal adhesion_Homo sapiens_hsa045102.06489152
5Pathogenic Escherichia coli infection_Homo sapiens_hsa051302.03484952
6Fatty acid elongation_Homo sapiens_hsa000621.96973566
7Leishmaniasis_Homo sapiens_hsa051401.96458766
8Leukocyte transendothelial migration_Homo sapiens_hsa046701.88001896
9Shigellosis_Homo sapiens_hsa051311.87054612
10Viral myocarditis_Homo sapiens_hsa054161.85696990
11Sulfur metabolism_Homo sapiens_hsa009201.84790534
12Malaria_Homo sapiens_hsa051441.83938730
13Glycosaminoglycan degradation_Homo sapiens_hsa005311.79685924
14Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.67789851
15Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.67345463
16Lysosome_Homo sapiens_hsa041421.61313161
17AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.58299314
18Legionellosis_Homo sapiens_hsa051341.55679825
19Other glycan degradation_Homo sapiens_hsa005111.54720916
20Chronic myeloid leukemia_Homo sapiens_hsa052201.52988537
21Antigen processing and presentation_Homo sapiens_hsa046121.47750237
22Proteoglycans in cancer_Homo sapiens_hsa052051.47338504
23Proteasome_Homo sapiens_hsa030501.46246149
24Vibrio cholerae infection_Homo sapiens_hsa051101.46184174
25Toxoplasmosis_Homo sapiens_hsa051451.45586093
26Small cell lung cancer_Homo sapiens_hsa052221.41571764
27Measles_Homo sapiens_hsa051621.40105152
28Apoptosis_Homo sapiens_hsa042101.37820260
29Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.35210164
30Dilated cardiomyopathy_Homo sapiens_hsa054141.35127155
31Amoebiasis_Homo sapiens_hsa051461.33831134
32DNA replication_Homo sapiens_hsa030301.29802022
33Protein export_Homo sapiens_hsa030601.27499036
34Adherens junction_Homo sapiens_hsa045201.27391200
35Platelet activation_Homo sapiens_hsa046111.26141218
36Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.26000968
37N-Glycan biosynthesis_Homo sapiens_hsa005101.24468032
38Pertussis_Homo sapiens_hsa051331.23630014
39Pancreatic cancer_Homo sapiens_hsa052121.17267774
40Osteoclast differentiation_Homo sapiens_hsa043801.16160624
41p53 signaling pathway_Homo sapiens_hsa041151.15648407
42Toll-like receptor signaling pathway_Homo sapiens_hsa046201.13579299
43Complement and coagulation cascades_Homo sapiens_hsa046101.12151553
44Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.10002239
45Galactose metabolism_Homo sapiens_hsa000521.06021196
46Salmonella infection_Homo sapiens_hsa051321.05282880
47Phagosome_Homo sapiens_hsa041451.05093850
48Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.04830458
49Vascular smooth muscle contraction_Homo sapiens_hsa042701.02727274
50TNF signaling pathway_Homo sapiens_hsa046681.01665398
51Hepatitis B_Homo sapiens_hsa051611.01460579
52Hematopoietic cell lineage_Homo sapiens_hsa046400.97591834
53Cell cycle_Homo sapiens_hsa041100.95533359
54Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.95202134
55NF-kappa B signaling pathway_Homo sapiens_hsa040640.94964736
56PI3K-Akt signaling pathway_Homo sapiens_hsa041510.94884430
57HTLV-I infection_Homo sapiens_hsa051660.94018616
58Protein digestion and absorption_Homo sapiens_hsa049740.93639319
59Regulation of actin cytoskeleton_Homo sapiens_hsa048100.93637347
60Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.93465733
61Jak-STAT signaling pathway_Homo sapiens_hsa046300.92122247
62Bladder cancer_Homo sapiens_hsa052190.90665326
63TGF-beta signaling pathway_Homo sapiens_hsa043500.89512967
64Gap junction_Homo sapiens_hsa045400.89483508
65Arachidonic acid metabolism_Homo sapiens_hsa005900.87751598
66Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.84752671
67Influenza A_Homo sapiens_hsa051640.84323727
68Biosynthesis of amino acids_Homo sapiens_hsa012300.84006907
69Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.83749524
70Acute myeloid leukemia_Homo sapiens_hsa052210.83507156
71Caffeine metabolism_Homo sapiens_hsa002320.82440023
72Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.82017166
73Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.81796531
74Viral carcinogenesis_Homo sapiens_hsa052030.80519458
75Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.79400291
76Herpes simplex infection_Homo sapiens_hsa051680.78991301
77Intestinal immune network for IgA production_Homo sapiens_hsa046720.78970167
78Base excision repair_Homo sapiens_hsa034100.78128570
79Primary immunodeficiency_Homo sapiens_hsa053400.78090473
80HIF-1 signaling pathway_Homo sapiens_hsa040660.77715932
81Rheumatoid arthritis_Homo sapiens_hsa053230.76493299
82B cell receptor signaling pathway_Homo sapiens_hsa046620.76049667
83Tuberculosis_Homo sapiens_hsa051520.75935596
84Pentose phosphate pathway_Homo sapiens_hsa000300.72950263
85Fructose and mannose metabolism_Homo sapiens_hsa000510.72087633
86Collecting duct acid secretion_Homo sapiens_hsa049660.70689851
87Staphylococcus aureus infection_Homo sapiens_hsa051500.70614264
88Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.69740841
89MicroRNAs in cancer_Homo sapiens_hsa052060.69513052
90Central carbon metabolism in cancer_Homo sapiens_hsa052300.69063342
912-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.66543380
92Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.65302373
93Neurotrophin signaling pathway_Homo sapiens_hsa047220.64700797
94Epstein-Barr virus infection_Homo sapiens_hsa051690.64540951
95Glutathione metabolism_Homo sapiens_hsa004800.61912409
96Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.61345330
97Hippo signaling pathway_Homo sapiens_hsa043900.60064425
98Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.59946801
99Pathways in cancer_Homo sapiens_hsa052000.58953709
100RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.57997708
101Endocytosis_Homo sapiens_hsa041440.57828059
102Fatty acid degradation_Homo sapiens_hsa000710.56455149
103Sulfur relay system_Homo sapiens_hsa041220.56249945
104Thyroid cancer_Homo sapiens_hsa052160.54933221
105Colorectal cancer_Homo sapiens_hsa052100.53908707
106Insulin resistance_Homo sapiens_hsa049310.53514536
107Carbon metabolism_Homo sapiens_hsa012000.53053634
108Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.51877227
109Renin-angiotensin system_Homo sapiens_hsa046140.50372843
110Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.49748595
111Primary bile acid biosynthesis_Homo sapiens_hsa001200.49710569
112Hepatitis C_Homo sapiens_hsa051600.48279202
113Allograft rejection_Homo sapiens_hsa053300.46483515
114Chemokine signaling pathway_Homo sapiens_hsa040620.46463205
115Steroid biosynthesis_Homo sapiens_hsa001000.45863312
116Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.44856377
117SNARE interactions in vesicular transport_Homo sapiens_hsa041300.42947617
118African trypanosomiasis_Homo sapiens_hsa051430.41408511
119Starch and sucrose metabolism_Homo sapiens_hsa005000.39624664
120Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.39299889
121Adipocytokine signaling pathway_Homo sapiens_hsa049200.39075411
122Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.38976754
123Prostate cancer_Homo sapiens_hsa052150.38760440
124Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.37929622
125Melanoma_Homo sapiens_hsa052180.37211991
126Rap1 signaling pathway_Homo sapiens_hsa040150.36573629
127Phospholipase D signaling pathway_Homo sapiens_hsa040720.36316369
128Tight junction_Homo sapiens_hsa045300.35200254
129Graft-versus-host disease_Homo sapiens_hsa053320.34527256
130Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.28648582
131Autoimmune thyroid disease_Homo sapiens_hsa053200.28436131

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