IMMP2L

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein involved in processing the signal peptide sequences used to direct mitochondrial proteins to the mitochondria. The encoded protein resides in the mitochondria and is one of the necessary proteins for the catalytic activity of the mitochondrial inner membrane peptidase (IMP) complex. Two variants that encode the same protein have been described for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.09710722
2L-phenylalanine catabolic process (GO:0006559)7.09710722
3erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.97325342
4L-phenylalanine metabolic process (GO:0006558)6.97325342
5aromatic amino acid family catabolic process (GO:0009074)6.14476267
6bile acid biosynthetic process (GO:0006699)5.64284139
7triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.59221818
8alpha-linolenic acid metabolic process (GO:0036109)5.44335544
9indole-containing compound catabolic process (GO:0042436)5.43935637
10indolalkylamine catabolic process (GO:0046218)5.43935637
11tryptophan catabolic process (GO:0006569)5.43935637
12fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)5.26744911
13kynurenine metabolic process (GO:0070189)5.20853846
14mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.13171244
15glyoxylate metabolic process (GO:0046487)5.05445140
16tryptophan metabolic process (GO:0006568)5.03785783
17high-density lipoprotein particle remodeling (GO:0034375)4.96640659
18urea metabolic process (GO:0019627)4.86495630
19urea cycle (GO:0000050)4.86495630
20regulation of cholesterol esterification (GO:0010872)4.76195951
21regulation of triglyceride catabolic process (GO:0010896)4.73194061
22bile acid metabolic process (GO:0008206)4.67837523
23nitrogen cycle metabolic process (GO:0071941)4.66292354
24negative regulation of fibrinolysis (GO:0051918)4.56655599
25proteasome assembly (GO:0043248)4.54385177
26aromatic amino acid family metabolic process (GO:0009072)4.50486967
27sulfur amino acid catabolic process (GO:0000098)4.49804911
28cysteine metabolic process (GO:0006534)4.48206053
29regulation of fibrinolysis (GO:0051917)4.41160380
30phospholipid efflux (GO:0033700)4.40434746
31ATP synthesis coupled proton transport (GO:0015986)4.37136286
32energy coupled proton transport, down electrochemical gradient (GO:0015985)4.37136286
33regulation of protein activation cascade (GO:2000257)4.35587792
34amino-acid betaine metabolic process (GO:0006577)4.35464641
35aldehyde catabolic process (GO:0046185)4.34637237
36mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.33699898
37serine family amino acid catabolic process (GO:0009071)4.30147398
38coenzyme catabolic process (GO:0009109)4.27401937
39peptidyl-glutamic acid carboxylation (GO:0017187)4.24129375
40protein carboxylation (GO:0018214)4.24129375
41protein complex biogenesis (GO:0070271)4.23075838
42alpha-amino acid catabolic process (GO:1901606)4.22513744
43complement activation, alternative pathway (GO:0006957)4.21384146
44plasma lipoprotein particle remodeling (GO:0034369)4.20516002
45protein-lipid complex remodeling (GO:0034368)4.20516002
46macromolecular complex remodeling (GO:0034367)4.20516002
47establishment of protein localization to mitochondrial membrane (GO:0090151)4.19098861
48respiratory chain complex IV assembly (GO:0008535)4.17153674
49lysine metabolic process (GO:0006553)4.14996059
50lysine catabolic process (GO:0006554)4.14996059
51mitochondrial respiratory chain complex assembly (GO:0033108)4.12225100
52cellular ketone body metabolic process (GO:0046950)4.12151568
53ethanol oxidation (GO:0006069)4.09723522
54reverse cholesterol transport (GO:0043691)4.08370168
55glycine metabolic process (GO:0006544)4.08320396
56tyrosine metabolic process (GO:0006570)4.05717097
57triglyceride homeostasis (GO:0070328)4.03778165
58acylglycerol homeostasis (GO:0055090)4.03778165
59regulation of complement activation (GO:0030449)4.03675705
60benzene-containing compound metabolic process (GO:0042537)3.95073427
61respiratory electron transport chain (GO:0022904)3.94935176
62rRNA modification (GO:0000154)3.93324903
63cellular amino acid catabolic process (GO:0009063)3.90374015
64electron transport chain (GO:0022900)3.89864353
65homocysteine metabolic process (GO:0050667)3.88599633
66mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.88227099
67mitochondrial respiratory chain complex I assembly (GO:0032981)3.88227099
68NADH dehydrogenase complex assembly (GO:0010257)3.88227099
69cofactor catabolic process (GO:0051187)3.87084365
70negative regulation of sterol transport (GO:0032372)3.87031890
71negative regulation of cholesterol transport (GO:0032375)3.87031890
72fatty acid beta-oxidation (GO:0006635)3.86317791
73negative regulation of lipase activity (GO:0060192)3.83518163
74cellular biogenic amine catabolic process (GO:0042402)3.82942235
75amine catabolic process (GO:0009310)3.82942235
76bile acid and bile salt transport (GO:0015721)3.82878710
77short-chain fatty acid metabolic process (GO:0046459)3.82463049
78very-low-density lipoprotein particle assembly (GO:0034379)3.80225225
79cytochrome complex assembly (GO:0017004)3.79566263
80cellular glucuronidation (GO:0052695)3.78890467
81plasma lipoprotein particle assembly (GO:0034377)3.78722305
82regulation of mitochondrial translation (GO:0070129)3.77006938
83fatty acid catabolic process (GO:0009062)3.76400347
84fatty acid oxidation (GO:0019395)3.75869440
85monocarboxylic acid catabolic process (GO:0072329)3.75338009
86serine family amino acid metabolic process (GO:0009069)3.75314909
87peptidyl-histidine modification (GO:0018202)3.74275111
88response to nitrosative stress (GO:0051409)3.73204520
89imidazole-containing compound metabolic process (GO:0052803)3.72772538
90carboxylic acid catabolic process (GO:0046395)3.72528723
91organic acid catabolic process (GO:0016054)3.72528723
92low-density lipoprotein particle remodeling (GO:0034374)3.70011331
93cholesterol efflux (GO:0033344)3.69933173
94serine family amino acid biosynthetic process (GO:0009070)3.69388026
95indolalkylamine metabolic process (GO:0006586)3.69195645
96chaperone-mediated protein transport (GO:0072321)3.68804971
97lipid oxidation (GO:0034440)3.67768936
98DNA double-strand break processing (GO:0000729)3.65193603
99blood coagulation, intrinsic pathway (GO:0007597)3.64704773
100plasma lipoprotein particle clearance (GO:0034381)3.63861342
101rRNA methylation (GO:0031167)3.58221868
102ribosomal large subunit biogenesis (GO:0042273)3.56905690
103ketone body metabolic process (GO:1902224)3.54740180
104NAD biosynthetic process (GO:0009435)3.53208904
105pyridine nucleotide biosynthetic process (GO:0019363)3.52990626
106nicotinamide nucleotide biosynthetic process (GO:0019359)3.52990626
107oxidative phosphorylation (GO:0006119)3.51947258
108xenobiotic catabolic process (GO:0042178)3.51494301
109flavonoid metabolic process (GO:0009812)3.50251273
110arginine metabolic process (GO:0006525)3.49876935
111carnitine metabolic process (GO:0009437)3.49697337
112aspartate family amino acid catabolic process (GO:0009068)3.49094810
113glucuronate metabolic process (GO:0019585)3.47410540
114uronic acid metabolic process (GO:0006063)3.47410540
115cullin deneddylation (GO:0010388)3.46404604
116acetyl-CoA metabolic process (GO:0006084)3.46053191
117transcription from mitochondrial promoter (GO:0006390)3.40522916
118glutamate metabolic process (GO:0006536)3.37909786
119drug catabolic process (GO:0042737)3.37710295
120branched-chain amino acid catabolic process (GO:0009083)3.35899529
121replication fork processing (GO:0031297)3.35246904
122protein neddylation (GO:0045116)3.34446064
123positive regulation of lipid catabolic process (GO:0050996)3.33716836
124regulation of cholesterol metabolic process (GO:0090181)3.30624628
125positive regulation of triglyceride lipase activity (GO:0061365)3.30603705
126positive regulation of lipoprotein lipase activity (GO:0051006)3.30603705
127protein-lipid complex assembly (GO:0065005)3.30530472
128water-soluble vitamin biosynthetic process (GO:0042364)3.28987698
129pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.28961136
130ribosomal small subunit assembly (GO:0000028)3.25865672
131protein deneddylation (GO:0000338)3.24673716
132regulation of glucokinase activity (GO:0033131)3.23191107
133regulation of hexokinase activity (GO:1903299)3.23191107
134protein K6-linked ubiquitination (GO:0085020)3.18656129
135branched-chain amino acid metabolic process (GO:0009081)3.18558065
136purine nucleobase biosynthetic process (GO:0009113)3.15390275
137inner mitochondrial membrane organization (GO:0007007)3.10937084
138nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.10173303
139protein targeting to mitochondrion (GO:0006626)3.08416887
140purine nucleotide salvage (GO:0032261)3.07148444
141pseudouridine synthesis (GO:0001522)3.06277491
142maturation of 5.8S rRNA (GO:0000460)3.06217069
143SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.05295861
144cotranslational protein targeting to membrane (GO:0006613)3.04698613
145exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.01824184
146ribosome assembly (GO:0042255)3.00419290
147lactate metabolic process (GO:0006089)2.94910715
148protein targeting to ER (GO:0045047)2.94660090
149CENP-A containing nucleosome assembly (GO:0034080)2.90944870
150negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.90707925
151intracellular protein transmembrane import (GO:0044743)2.89757771
152transcription elongation from RNA polymerase III promoter (GO:0006385)2.88879313
153termination of RNA polymerase III transcription (GO:0006386)2.88879313
154protein localization to endoplasmic reticulum (GO:0070972)2.88069247
155centriole replication (GO:0007099)2.88017208
156nucleobase biosynthetic process (GO:0046112)2.87655881
157protein localization to mitochondrion (GO:0070585)2.87421222
158deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.87353909
159positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.87175249
160translation (GO:0006412)2.86312807
161establishment of protein localization to endoplasmic reticulum (GO:0072599)2.86246540
162regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.85106203
163synapsis (GO:0007129)2.85098872
164chromatin remodeling at centromere (GO:0031055)2.82904121
165recombinational repair (GO:0000725)2.81679785
166cellular component biogenesis (GO:0044085)2.81529206
167regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.81461294
168double-strand break repair via homologous recombination (GO:0000724)2.78428700
169purine-containing compound salvage (GO:0043101)2.77524532
170translational termination (GO:0006415)2.77489537
171establishment of protein localization to mitochondrion (GO:0072655)2.77206220
172DNA catabolic process, exonucleolytic (GO:0000738)2.76910814
173histone H2A acetylation (GO:0043968)2.76138086
174viral transcription (GO:0019083)2.74361040
175regulation of cellular amino acid metabolic process (GO:0006521)2.73359234
176mitochondrial RNA metabolic process (GO:0000959)2.72703408
177pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.70704747
178regulation of acyl-CoA biosynthetic process (GO:0050812)2.69483947
179preassembly of GPI anchor in ER membrane (GO:0016254)2.69278867
180C-terminal protein lipidation (GO:0006501)2.68270539
181glutathione derivative biosynthetic process (GO:1901687)2.67908445
182glutathione derivative metabolic process (GO:1901685)2.67908445
183mitochondrial transport (GO:0006839)2.64486229
184mismatch repair (GO:0006298)2.64254040
185resolution of meiotic recombination intermediates (GO:0000712)2.64241185
186aggressive behavior (GO:0002118)2.63665406
187organelle disassembly (GO:1903008)2.62384017
188regulation of sulfur metabolic process (GO:0042762)2.61898512
189anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.61239983
190mannosylation (GO:0097502)2.57576971
191maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.57561488
192aerobic respiration (GO:0009060)2.57309094
193negative regulation of ligase activity (GO:0051352)2.57135253

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RXR_22158963_ChIP-Seq_LIVER_Mouse6.85617120
2EGR1_23403033_ChIP-Seq_LIVER_Mouse6.65626502
3PPARA_22158963_ChIP-Seq_LIVER_Mouse6.01874832
4PPARG_19300518_ChIP-PET_3T3-L1_Mouse5.35656835
5* LXR_22158963_ChIP-Seq_LIVER_Mouse5.14849443
6CEBPA_23403033_ChIP-Seq_LIVER_Mouse5.14526742
7FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.45560293
8CEBPB_23403033_ChIP-Seq_LIVER_Mouse4.24153738
9ELK1_19687146_ChIP-ChIP_HELA_Human3.04761290
10E2F7_22180533_ChIP-Seq_HELA_Human2.72148927
11NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.69070604
12SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.53570630
13E2F4_17652178_ChIP-ChIP_JURKAT_Human2.47411488
14MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.38478659
15TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.35770268
16PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.35742347
17HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.26105527
18HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.21311968
19SALL1_21062744_ChIP-ChIP_HESCs_Human2.11469889
20FUS_26573619_Chip-Seq_HEK293_Human2.09803945
21ESR1_17901129_ChIP-ChIP_LIVER_Mouse10.1180359
22FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.94645351
23PADI4_21655091_ChIP-ChIP_MCF-7_Human1.93343245
24EWS_26573619_Chip-Seq_HEK293_Human1.87875010
25POU3F2_20337985_ChIP-ChIP_501MEL_Human1.87834282
26ZNF274_21170338_ChIP-Seq_K562_Hela1.82518570
27* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.75753227
28E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.70962953
29NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.70371231
30KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.66621118
31IRF8_22096565_ChIP-ChIP_GC-B_Human1.65982339
32SRF_21415370_ChIP-Seq_HL-1_Mouse1.59272797
33TTF2_22483619_ChIP-Seq_HELA_Human1.55928137
34HTT_18923047_ChIP-ChIP_STHdh_Human1.54792562
35TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.53938859
36PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.52706684
37YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.50609895
38GABP_19822575_ChIP-Seq_HepG2_Human1.50414985
39JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.47802351
40FLI1_27457419_Chip-Seq_LIVER_Mouse1.47672512
41* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.46092801
42CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.41916025
43THAP11_20581084_ChIP-Seq_MESCs_Mouse1.41480554
44MYC_19079543_ChIP-ChIP_MESCs_Mouse1.38594461
45ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.35432909
46EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.33432510
47IGF1R_20145208_ChIP-Seq_DFB_Human1.33428585
48ELF1_17652178_ChIP-ChIP_JURKAT_Human1.30421545
49NELFA_20434984_ChIP-Seq_ESCs_Mouse1.30265797
50ZFP57_27257070_Chip-Seq_ESCs_Mouse1.27166134
51ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.24443930
52E2F1_21310950_ChIP-Seq_MCF-7_Human1.23353071
53CREB1_15753290_ChIP-ChIP_HEK293T_Human1.21993778
54PCGF2_27294783_Chip-Seq_ESCs_Mouse1.19512456
55LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.19307272
56AR_21909140_ChIP-Seq_LNCAP_Human1.19248858
57* P300_19829295_ChIP-Seq_ESCs_Human1.19153824
58XRN2_22483619_ChIP-Seq_HELA_Human1.18736687
59PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.18284791
60GBX2_23144817_ChIP-Seq_PC3_Human1.17029819
61RXRA_24833708_ChIP-Seq_LIVER_Mouse1.15728034
62STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.15488981
63EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.15297681
64HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.14234312
65ELK1_22589737_ChIP-Seq_MCF10A_Human1.14062303
66GABP_17652178_ChIP-ChIP_JURKAT_Human1.12772738
67RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.11149550
68POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.10789117
69KAP1_22055183_ChIP-Seq_ESCs_Mouse1.09719308
70VDR_22108803_ChIP-Seq_LS180_Human1.09679708
71KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.08329772
72EZH2_27294783_Chip-Seq_NPCs_Mouse1.07662096
73* RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.07253052
74TP53_22573176_ChIP-Seq_HFKS_Human1.07024666
75PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.06706809
76MYCN_18555785_ChIP-Seq_MESCs_Mouse1.06640735
77IRF1_19129219_ChIP-ChIP_H3396_Human1.05475131
78MYC_18358816_ChIP-ChIP_MESCs_Mouse1.04227606
79* ER_23166858_ChIP-Seq_MCF-7_Human1.03726070
80FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.03471503
81BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.03099402
82EST1_17652178_ChIP-ChIP_JURKAT_Human1.02283310
83POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.01719614
84TAF15_26573619_Chip-Seq_HEK293_Human1.00991073
85MYC_18555785_ChIP-Seq_MESCs_Mouse1.00778106
86PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.00775859
87MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.00584382
88IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.99876688
89* HNF4A_19822575_ChIP-Seq_HepG2_Human0.99848041
90KDM5A_27292631_Chip-Seq_BREAST_Human0.98679555
91GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98159639
92IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.97780406
93SUZ12_27294783_Chip-Seq_NPCs_Mouse0.96177871
94* SOX2_19829295_ChIP-Seq_ESCs_Human0.95613125
95* NANOG_19829295_ChIP-Seq_ESCs_Human0.95613125
96CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.94212012
97CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.93783141
98AR_20517297_ChIP-Seq_VCAP_Human0.93080640
99GATA1_22025678_ChIP-Seq_K562_Human0.92923673
100MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.89800935
101FOXA1_25329375_ChIP-Seq_VCAP_Human0.89751084
102FOXA1_27270436_Chip-Seq_PROSTATE_Human0.89751084
103* E2F1_18555785_ChIP-Seq_MESCs_Mouse0.88788200
104ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.88517154
105AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.88500141
106CTBP1_25329375_ChIP-Seq_LNCAP_Human0.87535770
107* SALL4_22934838_ChIP-ChIP_CD34+_Human0.86328345
108RAD21_21589869_ChIP-Seq_MESCs_Mouse0.85255145
109HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.81375911
110FOXA2_19822575_ChIP-Seq_HepG2_Human0.80180194
111SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.80060138
112* FOXP3_21729870_ChIP-Seq_TREG_Human0.80038031
113DCP1A_22483619_ChIP-Seq_HELA_Human0.79684879
114ERG_20517297_ChIP-Seq_VCAP_Human0.79143300
115SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.78186243
116RARA_24833708_ChIP-Seq_LIVER_Mouse0.78117315
117HOXB4_20404135_ChIP-ChIP_EML_Mouse0.77426179
118LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.76174916
119GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.76156859
120ETS1_20019798_ChIP-Seq_JURKAT_Human0.75618634
121PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.75547308
122NOTCH1_21737748_ChIP-Seq_TLL_Human0.75528455
123BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.75282077
124* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.74085660
125ERG_20887958_ChIP-Seq_HPC-7_Mouse0.73998591
126AUTS2_25519132_ChIP-Seq_293T-REX_Human0.73893219
127SCL_19346495_ChIP-Seq_HPC-7_Human0.71919317
128ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.69807533
129TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.68722636
130SOX2_22085726_ChIP-Seq_NPCs_Mouse0.67878115
131GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.67052730
132CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.66655745
133BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.66528881
134RARB_24833708_ChIP-Seq_LIVER_Mouse0.66120787
135CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.66050111
136NANOG_20526341_ChIP-Seq_ESCs_Human0.65487468
137CEBPB_22108803_ChIP-Seq_LS180_Human0.64767631
138ESET_19884257_ChIP-Seq_ESCs_Mouse0.63983857
139GATA3_21867929_ChIP-Seq_CD8_Mouse0.63911680
140P53_21459846_ChIP-Seq_SAOS-2_Human0.63423684
141YY1_21170310_ChIP-Seq_MESCs_Mouse0.63229365
142LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse0.62905301
143STAT1_17558387_ChIP-Seq_HELA_Human0.62811708
144CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.62664040
145PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.62535324
146MYC_18940864_ChIP-ChIP_HL60_Human0.61023834
147GATA2_22383799_ChIP-Seq_G1ME_Mouse0.59014901
148VDR_23849224_ChIP-Seq_CD4+_Human0.58635983
149ZNF263_19887448_ChIP-Seq_K562_Human0.58111472
150ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.57957180
151GATA4_25053715_ChIP-Seq_YYC3_Human0.57936415
152CTCF_18555785_ChIP-Seq_MESCs_Mouse0.57685640
153TET1_21451524_ChIP-Seq_MESCs_Mouse0.57289932
154STAT1_20625510_ChIP-Seq_HELA_Human0.57252921
155GATA1_22383799_ChIP-Seq_G1ME_Mouse0.56597687
156CRX_20693478_ChIP-Seq_RETINA_Mouse0.54117672
157NFE2_27457419_Chip-Seq_LIVER_Mouse0.54034742
158FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.51776974

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system7.65846891
2MP0005360_urolithiasis6.63635069
3MP0005365_abnormal_bile_salt6.20576005
4MP0005085_abnormal_gallbladder_physiolo6.18692517
5MP0008875_abnormal_xenobiotic_pharmacok4.99557784
6MP0003806_abnormal_nucleotide_metabolis4.32984790
7MP0008058_abnormal_DNA_repair3.68388007
8MP0010329_abnormal_lipoprotein_level3.31578995
9MP0000372_irregular_coat_pigmentation3.19403098
10MP0003252_abnormal_bile_duct3.19008475
11MP0005083_abnormal_biliary_tract3.16057118
12MP0008877_abnormal_DNA_methylation2.92023134
13MP0010094_abnormal_chromosome_stability2.84714516
14MP0009840_abnormal_foam_cell2.79228357
15MP0001666_abnormal_nutrient_absorption2.72382480
16MP0006072_abnormal_retinal_apoptosis2.67425482
17MP0003195_calcinosis2.65420328
18MP0005332_abnormal_amino_acid2.59892998
19MP0008057_abnormal_DNA_replication2.54279195
20MP0009379_abnormal_foot_pigmentation2.30575180
21MP0003011_delayed_dark_adaptation2.28240262
22MP0003191_abnormal_cellular_cholesterol2.15377315
23MP0001764_abnormal_homeostasis2.03325190
24MP0004019_abnormal_vitamin_homeostasis2.01489892
25MP0002118_abnormal_lipid_homeostasis2.01352003
26MP0000609_abnormal_liver_physiology1.96682850
27* MP0006036_abnormal_mitochondrial_physio1.92501397
28MP0002938_white_spotting1.91404332
29MP0003186_abnormal_redox_activity1.89304929
30MP0003868_abnormal_feces_composition1.88544285
31MP0005319_abnormal_enzyme/_coenzyme1.85026362
32MP0003786_premature_aging1.83249107
33MP0003693_abnormal_embryo_hatching1.76207436
34MP0005584_abnormal_enzyme/coenzyme_acti1.75721567
35MP0005253_abnormal_eye_physiology1.61832546
36MP0006292_abnormal_olfactory_placode1.60736362
37MP0004957_abnormal_blastocyst_morpholog1.55480714
38* MP0009697_abnormal_copulation1.54863256
39MP0003077_abnormal_cell_cycle1.50348821
40MP0002638_abnormal_pupillary_reflex1.47821262
41MP0005551_abnormal_eye_electrophysiolog1.47496716
42MP0003111_abnormal_nucleus_morphology1.47063003
43MP0002138_abnormal_hepatobiliary_system1.46044119
44MP0010386_abnormal_urinary_bladder1.44765359
45MP0008932_abnormal_embryonic_tissue1.42044677
46MP0005645_abnormal_hypothalamus_physiol1.40322535
47MP0008007_abnormal_cellular_replicative1.35562752
48MP0000383_abnormal_hair_follicle1.33999707
49MP0006035_abnormal_mitochondrial_morpho1.33184500
50MP0003656_abnormal_erythrocyte_physiolo1.32494123
51MP0000566_synostosis1.31501916
52MP0008789_abnormal_olfactory_epithelium1.27301880
53MP0000358_abnormal_cell_content/1.27287383
54MP0002876_abnormal_thyroid_physiology1.25805971
55MP0005670_abnormal_white_adipose1.22716318
56MP0008995_early_reproductive_senescence1.22679138
57MP0009643_abnormal_urine_homeostasis1.20472838
58MP0005451_abnormal_body_composition1.19942478
59MP0010678_abnormal_skin_adnexa1.19261557
60MP0005395_other_phenotype1.19189909
61MP0003283_abnormal_digestive_organ1.19044944
62MP0004215_abnormal_myocardial_fiber1.16191786
63MP0003136_yellow_coat_color1.14408036
64MP0005636_abnormal_mineral_homeostasis1.13288529
65MP0004145_abnormal_muscle_electrophysio1.12335721
66MP0006276_abnormal_autonomic_nervous1.09133536
67MP0005084_abnormal_gallbladder_morpholo1.08598242
68MP0005647_abnormal_sex_gland1.07859643
69MP0002210_abnormal_sex_determination1.06149167
70MP0000598_abnormal_liver_morphology1.06018714
71MP0002090_abnormal_vision1.05961623
72MP0005410_abnormal_fertilization1.03806007
73MP0002160_abnormal_reproductive_system1.01724574
74* MP0000653_abnormal_sex_gland1.01482638
75MP0009763_increased_sensitivity_to1.00017522
76MP0008469_abnormal_protein_level0.99732725
77MP0005535_abnormal_body_temperature0.98685796
78MP0009764_decreased_sensitivity_to0.98112560
79MP0001905_abnormal_dopamine_level0.96466596
80MP0001984_abnormal_olfaction0.96384929
81MP0008775_abnormal_heart_ventricle0.95509857
82MP0000427_abnormal_hair_cycle0.94704496
83MP0002971_abnormal_brown_adipose0.93178070
84MP0002102_abnormal_ear_morphology0.92343879
85MP0002163_abnormal_gland_morphology0.92008664
86MP0005266_abnormal_metabolism0.91918456
87MP0004130_abnormal_muscle_cell0.90333395
88MP0009642_abnormal_blood_homeostasis0.90222572
89MP0001145_abnormal_male_reproductive0.89262493
90MP0004147_increased_porphyrin_level0.88639032
91MP0003787_abnormal_imprinting0.88602726
92MP0005376_homeostasis/metabolism_phenot0.88190152
93MP0003121_genomic_imprinting0.85705049
94MP0005075_abnormal_melanosome_morpholog0.85635202
95MP0008872_abnormal_physiological_respon0.84825354
96MP0002234_abnormal_pharynx_morphology0.83381675
97* MP0003698_abnormal_male_reproductive0.83126546
98MP0009765_abnormal_xenobiotic_induced0.83005364
99MP0002095_abnormal_skin_pigmentation0.80187942
100MP0000013_abnormal_adipose_tissue0.79500554
101MP0005408_hypopigmentation0.78830703
102MP0002078_abnormal_glucose_homeostasis0.78725601
103MP0005367_renal/urinary_system_phenotyp0.78507491
104MP0000516_abnormal_urinary_system0.78507491
105MP0002736_abnormal_nociception_after0.78283910
106MP0002837_dystrophic_cardiac_calcinosis0.77559343
107MP0003950_abnormal_plasma_membrane0.77210487
108MP0003724_increased_susceptibility_to0.75443384
109MP0000631_abnormal_neuroendocrine_gland0.74581577
110MP0003880_abnormal_central_pattern0.72861765
111MP0001881_abnormal_mammary_gland0.72637588
112MP0002254_reproductive_system_inflammat0.72285476
113MP0004133_heterotaxia0.72098519
114MP0001944_abnormal_pancreas_morphology0.70937565
115MP0000647_abnormal_sebaceous_gland0.70912917
116MP0004782_abnormal_surfactant_physiolog0.70431276
117MP0005464_abnormal_platelet_physiology0.68975875
118MP0004381_abnormal_hair_follicle0.68525103
119MP0001324_abnormal_eye_pigmentation0.67260261
120MP0002132_abnormal_respiratory_system0.66051867
121MP0005334_abnormal_fat_pad0.64363504
122MP0005448_abnormal_energy_balance0.63177813
123MP0005220_abnormal_exocrine_pancreas0.61541963
124MP0010368_abnormal_lymphatic_system0.60816113
125MP0000639_abnormal_adrenal_gland0.60077695
126MP0003718_maternal_effect0.55321744
127MP0003638_abnormal_response/metabolism_0.53281700
128MP0008873_increased_physiological_sensi0.53084458
129MP0005666_abnormal_adipose_tissue0.51498539
130MP0001756_abnormal_urination0.49867925
131MP0000230_abnormal_systemic_arterial0.48655432
132MP0005646_abnormal_pituitary_gland0.47698648
133MP0001853_heart_inflammation0.46685996
134MP0001661_extended_life_span0.46447760
135MP0003953_abnormal_hormone_level0.45144235
136MP0002822_catalepsy0.42181549
137MP0002970_abnormal_white_adipose0.41851399
138MP0003646_muscle_fatigue0.41411821
139MP0002136_abnormal_kidney_physiology0.40222425
140MP0008874_decreased_physiological_sensi0.39824756
141MP0000604_amyloidosis0.39597710
142MP0009785_altered_susceptibility_to0.36591035
143MP0005379_endocrine/exocrine_gland_phen0.36199753
144MP0004043_abnormal_pH_regulation0.35901493
145MP0005330_cardiomyopathy0.33913057
146MP0003943_abnormal_hepatobiliary_system0.32179814
147MP0001845_abnormal_inflammatory_respons0.31844212
148MP0009115_abnormal_fat_cell0.31393589
149MP0005025_abnormal_response_to0.29234257
150MP0002928_abnormal_bile_duct0.29224854
151MP0001529_abnormal_vocalization0.28888229
152MP0001986_abnormal_taste_sensitivity0.28656970
153MP0003690_abnormal_glial_cell0.28057337
154MP0004142_abnormal_muscle_tone0.28052433
155MP0002332_abnormal_exercise_endurance0.26123017
156* MP0001929_abnormal_gametogenesis0.25960242
157MP0003959_abnormal_lean_body0.24357308
158MP0005595_abnormal_vascular_smooth0.23454018
159MP0005166_decreased_susceptibility_to0.21913448

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)6.63293054
2Intrahepatic cholestasis (HP:0001406)5.97516370
3Hypobetalipoproteinemia (HP:0003563)5.95468790
4Prolonged partial thromboplastin time (HP:0003645)5.40580361
5Deep venous thrombosis (HP:0002625)5.38541731
6Abnormality of monocarboxylic acid metabolism (HP:0010996)5.25773308
7Xanthomatosis (HP:0000991)4.79689440
8Hyperlipoproteinemia (HP:0010980)4.33446944
9Hyperammonemia (HP:0001987)4.28391867
10Hypolipoproteinemia (HP:0010981)4.14209099
11Abnormality of methionine metabolism (HP:0010901)3.99334656
12Hypoglycemic coma (HP:0001325)3.98552480
13Hyperglycinemia (HP:0002154)3.98408376
14Abnormality of fatty-acid metabolism (HP:0004359)3.92878468
15Ketosis (HP:0001946)3.86773192
16Abnormality of aspartate family amino acid metabolism (HP:0010899)3.81755105
17Cerebral edema (HP:0002181)3.80446207
18Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.79459789
19Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.78449141
20Fat malabsorption (HP:0002630)3.77180450
21Hepatic necrosis (HP:0002605)3.74046135
22Complement deficiency (HP:0004431)3.73952493
23Conjugated hyperbilirubinemia (HP:0002908)3.57950810
24Joint hemorrhage (HP:0005261)3.55178287
25Epidermoid cyst (HP:0200040)3.53918223
26Abnormality of serine family amino acid metabolism (HP:0010894)3.49392151
27Abnormality of glycine metabolism (HP:0010895)3.49392151
28Hyperglycinuria (HP:0003108)3.48736226
29Dicarboxylic aciduria (HP:0003215)3.39648493
30Abnormality of dicarboxylic acid metabolism (HP:0010995)3.39648493
31Abnormality of sulfur amino acid metabolism (HP:0004339)3.32101735
32Acute encephalopathy (HP:0006846)3.30335359
33Hepatocellular necrosis (HP:0001404)3.27234358
34Abnormality of the common coagulation pathway (HP:0010990)3.26933983
35Lethargy (HP:0001254)3.25356809
36Hyperbilirubinemia (HP:0002904)3.23841329
37Hypoalphalipoproteinemia (HP:0003233)3.20123807
38Abnormality of serum amino acid levels (HP:0003112)3.19306044
39Generalized aminoaciduria (HP:0002909)3.12393137
40Type I transferrin isoform profile (HP:0003642)3.11258026
41Hypercholesterolemia (HP:0003124)3.09704808
42Steatorrhea (HP:0002570)3.08316256
43Abnormality of the intrinsic pathway (HP:0010989)3.08289289
44Abnormality of pyrimidine metabolism (HP:0004353)3.07361802
45Abnormality of glutamine family amino acid metabolism (HP:0010902)3.00600936
46Medial flaring of the eyebrow (HP:0010747)2.99042561
47Metabolic acidosis (HP:0001942)2.96576964
48Ketoacidosis (HP:0001993)2.82159225
49Acute necrotizing encephalopathy (HP:0006965)2.81886494
50Renal cortical cysts (HP:0000803)2.78653408
51Respiratory failure (HP:0002878)2.73767139
52Abnormal mitochondria in muscle tissue (HP:0008316)2.73185903
53Mitochondrial inheritance (HP:0001427)2.69653658
54Delayed CNS myelination (HP:0002188)2.68143367
55Decreased activity of mitochondrial respiratory chain (HP:0008972)2.66642010
56Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.66642010
57Spontaneous abortion (HP:0005268)2.64897813
58Increased CSF lactate (HP:0002490)2.63352895
59Abnormality of complement system (HP:0005339)2.61013933
60Lactic acidosis (HP:0003128)2.59652255
61Increased muscle lipid content (HP:0009058)2.59646625
62Exercise intolerance (HP:0003546)2.59574826
63Pancreatic fibrosis (HP:0100732)2.58777191
64Hyperinsulinemic hypoglycemia (HP:0000825)2.56741876
65Pancreatic cysts (HP:0001737)2.53712265
66Congenital primary aphakia (HP:0007707)2.53126552
67Vomiting (HP:0002013)2.51489849
68Exertional dyspnea (HP:0002875)2.48423507
69Cholecystitis (HP:0001082)2.48278481
70Abnormal gallbladder physiology (HP:0012438)2.48278481
71Reticulocytopenia (HP:0001896)2.47418999
72Abnormality of nucleobase metabolism (HP:0010932)2.45602773
73Glycosuria (HP:0003076)2.41331742
74Abnormality of urine glucose concentration (HP:0011016)2.41331742
75Lipid accumulation in hepatocytes (HP:0006561)2.40826822
76Increased intramyocellular lipid droplets (HP:0012240)2.37763405
77Nephrogenic diabetes insipidus (HP:0009806)2.37569003
78Hypothermia (HP:0002045)2.37157668
79Proximal tubulopathy (HP:0000114)2.34668231
80Brushfield spots (HP:0001088)2.34358302
81Chromsome breakage (HP:0040012)2.34187254
82Increased serum pyruvate (HP:0003542)2.33633593
83Abnormality of glycolysis (HP:0004366)2.33633593
84Gait imbalance (HP:0002141)2.33400046
85True hermaphroditism (HP:0010459)2.32408035
86Renal Fanconi syndrome (HP:0001994)2.30718699
87Progressive macrocephaly (HP:0004481)2.30603721
88Colon cancer (HP:0003003)2.30603542
893-Methylglutaconic aciduria (HP:0003535)2.29931846
90Ragged-red muscle fibers (HP:0003200)2.29602647
91Opisthotonus (HP:0002179)2.29440716
92Abnormal protein glycosylation (HP:0012346)2.29302421
93Abnormal glycosylation (HP:0012345)2.29302421
94Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.29302421
95Abnormal protein N-linked glycosylation (HP:0012347)2.29302421
96Abnormality of midbrain morphology (HP:0002418)2.28465964
97Molar tooth sign on MRI (HP:0002419)2.28465964
98Abnormality of alanine metabolism (HP:0010916)2.26954852
99Hyperalaninemia (HP:0003348)2.26954852
100Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.26954852
101Increased serum lactate (HP:0002151)2.25127493
102Symptomatic seizures (HP:0011145)2.23573286
103Abnormality of the anterior horn cell (HP:0006802)2.22244036
104Degeneration of anterior horn cells (HP:0002398)2.22244036
105Optic disc pallor (HP:0000543)2.18762083
106Methylmalonic aciduria (HP:0012120)2.16850644
107Skin nodule (HP:0200036)2.16274136
108Abnormality of renal resorption (HP:0011038)2.16233050
109Abnormality of purine metabolism (HP:0004352)2.14723258
110Median cleft lip (HP:0000161)2.11809437
111Leukodystrophy (HP:0002415)2.10417529
112Acanthocytosis (HP:0001927)2.10175105
113Respiratory difficulties (HP:0002880)2.08989988
114Pancreatitis (HP:0001733)2.08514391
115Chromosomal breakage induced by crosslinking agents (HP:0003221)2.08070837
116Elevated hepatic transaminases (HP:0002910)2.07227262
117Abnormal hemoglobin (HP:0011902)2.06958489
118Abnormal gallbladder morphology (HP:0012437)2.06780701
119Abnormality of vitamin metabolism (HP:0100508)2.06252311
120CNS demyelination (HP:0007305)2.06096666
121Hepatocellular carcinoma (HP:0001402)2.05389078
122Abnormal number of erythroid precursors (HP:0012131)2.05252943
123Late onset (HP:0003584)2.03368197
124Malnutrition (HP:0004395)2.03150613
125Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.03105659
126Abnormality of chromosome stability (HP:0003220)2.01263120
127Nephronophthisis (HP:0000090)2.01210328
128Menorrhagia (HP:0000132)2.01005969
129Cholelithiasis (HP:0001081)2.00630680
130Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.00448407
131Reduced antithrombin III activity (HP:0001976)2.00273808
132Hypoglycemic seizures (HP:0002173)1.98204958
133Microvesicular hepatic steatosis (HP:0001414)1.98056582
134Cerebral palsy (HP:0100021)1.97482385
135Vascular calcification (HP:0004934)1.97451096
136Aplasia/Hypoplasia of the uvula (HP:0010293)1.96098226
137Macrocytic anemia (HP:0001972)1.96073483
138Increased hepatocellular lipid droplets (HP:0006565)1.95999617
139Nausea (HP:0002018)1.95809270
140Methylmalonic acidemia (HP:0002912)1.94726405
141Hypochromic microcytic anemia (HP:0004840)1.93134787
142Pancytopenia (HP:0001876)1.90952907
143Systemic lupus erythematosus (HP:0002725)1.90933823
144Abnormality of cells of the erythroid lineage (HP:0012130)1.88810810
145Metaphyseal dysplasia (HP:0100255)1.88221404
146Abnormality of lateral ventricle (HP:0030047)1.87474772
147Bile duct proliferation (HP:0001408)1.87094828
148Abnormal biliary tract physiology (HP:0012439)1.87094828
149Aplasia/Hypoplasia of the fovea (HP:0008060)1.83176525
150Hypoplasia of the fovea (HP:0007750)1.83176525
151Hyperphosphaturia (HP:0003109)1.82583441
152Aplastic anemia (HP:0001915)1.81958314
153Aplasia/Hypoplasia of the tongue (HP:0010295)1.80107255
154Short tibia (HP:0005736)1.79242891
155Pancreatic islet-cell hyperplasia (HP:0004510)1.77420833
156Neoplasm of the adrenal gland (HP:0100631)1.75925829
157Abnormality of the fovea (HP:0000493)1.75116908

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK6.75018448
2MST44.15388915
3NME23.37306945
4PDK42.86527757
5PDK32.86527757
6FLT32.77881992
7VRK22.59194999
8EIF2AK32.55257794
9TAOK32.52422659
10MAP4K22.52190108
11STK162.30475744
12FGFR42.28376921
13ERN12.25660048
14PINK12.19246785
15CDC71.95047344
16SRPK11.92405606
17PIK3CG1.92048884
18MUSK1.86883121
19INSRR1.74998362
20SIK11.70816057
21NEK11.66993554
22TLK11.64699177
23BUB11.60231333
24MYLK1.59764605
25PLK41.57161041
26KDR1.55085215
27PLK31.50179346
28NME11.49380627
29KIT1.46443960
30TIE11.41701679
31MAPK111.41474410
32PNCK1.38613211
33NEK91.33324882
34BMPR1B1.32661329
35MST1R1.32544086
36MKNK11.30526829
37TYK21.29246247
38WNK31.27962683
39PDK21.27896819
40CDK191.26446335
41ERBB41.26192571
42IKBKE1.24957269
43TGFBR21.24191217
44MAP2K61.23450105
45MAP3K121.16071134
46TBK11.15699011
47TGFBR11.15630230
48MAPKAPK51.12779729
49TTK1.11251714
50ERBB31.07768087
51TEC1.07324129
52ABL21.06965265
53IRAK31.04102357
54ADRBK21.00680639
55BRSK20.98418578
56PASK0.97144135
57PLK10.97107338
58VRK10.96939324
59PKN20.95334687
60DAPK20.95196403
61BCR0.94725423
62ACVR1B0.94361192
63TRIM280.92442939
64SCYL20.92099671
65MAPK150.91743010
66MAPK40.88769124
67TAF10.87877649
68TNIK0.87753159
69GRK10.86937093
70STK38L0.86650004
71STK30.86073591
72EIF2AK20.85796607
73MAP3K40.85550321
74MAP3K110.84786011
75MAP4K10.83715700
76ATR0.82077211
77CDK80.81224653
78PRKAA20.81219444
79BTK0.81001613
80CSNK1A1L0.80344844
81STK390.78435827
82CAMK2G0.78186867
83EIF2AK10.75479864
84BRSK10.75409070
85CSNK1G20.74119279
86AURKB0.72808966
87FRK0.72521434
88BRAF0.72518716
89MKNK20.71773185
90MAP2K40.71398330
91WNK40.70712819
92WEE10.70126666
93PRKG20.69006297
94PLK20.68051968
95PHKG20.67656621
96PHKG10.67656621
97CSF1R0.65164666
98CSNK1G30.64575052
99LMTK20.62888427
100PIK3CA0.62667500
101CASK0.62290119
102ZAK0.61084199
103RAF10.60978886
104IRAK10.60894347
105ATM0.59757966
106AKT30.55428054
107MAPK130.54808079
108CSNK1G10.54605585
109CHEK20.53886039
110PRKCE0.53496859
111OBSCN0.53231442
112ARAF0.53050928
113RPS6KA40.52660420
114TSSK60.51689613
115PBK0.51581950
116DYRK20.51410344
117NUAK10.51275559
118JAK20.50515274
119STK40.49969582
120MAPK120.47647838
121PDK10.47583894
122TXK0.47173721
123GRK70.46318858
124GRK60.45949074
125PRKACG0.45308846
126PIM20.45250215
127FGFR20.44338863
128ERBB20.43018891
129RPS6KA50.42216497
130CSNK2A10.41930287
131CCNB10.40427423
132ZAP700.40233241
133PDPK10.39002048
134OXSR10.37911646
135AURKA0.37902612
136IKBKB0.36956623
137ILK0.36678120
138RPS6KB20.36430403
139BMPR20.36329337
140CSNK2A20.36181524
141MAP2K70.35875696
142SIK30.34525290
143MAP3K70.34084670
144GRK50.33517723
145TNK20.33424377
146CSNK1A10.33095962
147PRKACA0.32141521
148DAPK10.31962457
149FER0.31774960
150CDK30.28426432
151PTK2B0.26937095
152CSNK1E0.24969862

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.17660880
2Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.93668422
3Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.71778818
4Propanoate metabolism_Homo sapiens_hsa006402.59628017
5Mismatch repair_Homo sapiens_hsa034302.55380796
6Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.54863717
7Nitrogen metabolism_Homo sapiens_hsa009102.52931843
8Fatty acid degradation_Homo sapiens_hsa000712.52269744
9Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.52071755
10Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.50438425
11Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.38946941
12Arginine biosynthesis_Homo sapiens_hsa002202.37720582
13Tryptophan metabolism_Homo sapiens_hsa003802.30837598
14Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.29685056
15Pentose and glucuronate interconversions_Homo sapiens_hsa000402.26460517
16Peroxisome_Homo sapiens_hsa041462.21324788
17Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.18770418
18Chemical carcinogenesis_Homo sapiens_hsa052042.15151048
19Complement and coagulation cascades_Homo sapiens_hsa046102.10154069
20Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.08889467
21Fanconi anemia pathway_Homo sapiens_hsa034602.05891260
22Non-homologous end-joining_Homo sapiens_hsa034501.92778986
23Butanoate metabolism_Homo sapiens_hsa006501.90832735
24Nucleotide excision repair_Homo sapiens_hsa034201.90821955
25Fatty acid metabolism_Homo sapiens_hsa012121.89309531
26Fatty acid elongation_Homo sapiens_hsa000621.83895516
27Drug metabolism - other enzymes_Homo sapiens_hsa009831.79693205
28Pyruvate metabolism_Homo sapiens_hsa006201.78101663
29Steroid hormone biosynthesis_Homo sapiens_hsa001401.78051330
30Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.77885543
31Retinol metabolism_Homo sapiens_hsa008301.76292667
32PPAR signaling pathway_Homo sapiens_hsa033201.74458934
33Histidine metabolism_Homo sapiens_hsa003401.69885123
34Folate biosynthesis_Homo sapiens_hsa007901.65048302
35Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.62765528
36beta-Alanine metabolism_Homo sapiens_hsa004101.59385963
37Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.58580553
38Basal transcription factors_Homo sapiens_hsa030221.56681282
39Sulfur relay system_Homo sapiens_hsa041221.55168709
402-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.50487474
41Caffeine metabolism_Homo sapiens_hsa002321.48203864
42Selenocompound metabolism_Homo sapiens_hsa004501.47812331
43Carbon metabolism_Homo sapiens_hsa012001.41151340
44Cysteine and methionine metabolism_Homo sapiens_hsa002701.39081643
45Cyanoamino acid metabolism_Homo sapiens_hsa004601.36721582
46Sulfur metabolism_Homo sapiens_hsa009201.34642779
47Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.32777355
48RNA degradation_Homo sapiens_hsa030181.32199972
49Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.31274435
50Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.30248062
51Starch and sucrose metabolism_Homo sapiens_hsa005001.26848051
52Vitamin B6 metabolism_Homo sapiens_hsa007501.26443396
53Phenylalanine metabolism_Homo sapiens_hsa003601.25336465
54Tyrosine metabolism_Homo sapiens_hsa003501.24934539
55RNA transport_Homo sapiens_hsa030131.19271558
56Biosynthesis of amino acids_Homo sapiens_hsa012301.18355895
57Oxidative phosphorylation_Homo sapiens_hsa001901.16513701
58Regulation of autophagy_Homo sapiens_hsa041401.14876729
59ABC transporters_Homo sapiens_hsa020101.14109074
60Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.14045994
61Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.13902289
62Fat digestion and absorption_Homo sapiens_hsa049751.12295790
63Glutathione metabolism_Homo sapiens_hsa004801.11984959
64Staphylococcus aureus infection_Homo sapiens_hsa051501.11584786
65Bile secretion_Homo sapiens_hsa049761.05531793
66Parkinsons disease_Homo sapiens_hsa050121.03245698
67Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.96941438
68Ribosome_Homo sapiens_hsa030100.96703084
69Steroid biosynthesis_Homo sapiens_hsa001000.95893464
70Spliceosome_Homo sapiens_hsa030400.95836846
71Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.90555171
72Pentose phosphate pathway_Homo sapiens_hsa000300.88634970
73Maturity onset diabetes of the young_Homo sapiens_hsa049500.88442124
74Arginine and proline metabolism_Homo sapiens_hsa003300.83498562
75Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.81668021
76Metabolic pathways_Homo sapiens_hsa011000.74433882
77One carbon pool by folate_Homo sapiens_hsa006700.71170288
78Vitamin digestion and absorption_Homo sapiens_hsa049770.70090626
79Collecting duct acid secretion_Homo sapiens_hsa049660.69640770
80Glycerolipid metabolism_Homo sapiens_hsa005610.66500079
81Alzheimers disease_Homo sapiens_hsa050100.63775152
82Cell cycle_Homo sapiens_hsa041100.62016137
83Huntingtons disease_Homo sapiens_hsa050160.60973004
84Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.58043988
85Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.53837527
86N-Glycan biosynthesis_Homo sapiens_hsa005100.49753087
87Galactose metabolism_Homo sapiens_hsa000520.46784699
88Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.46746263
89Phototransduction_Homo sapiens_hsa047440.46555800
90SNARE interactions in vesicular transport_Homo sapiens_hsa041300.45448203
91Fatty acid biosynthesis_Homo sapiens_hsa000610.45071500
92Lysine degradation_Homo sapiens_hsa003100.44518008
93Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.43864031
94Fructose and mannose metabolism_Homo sapiens_hsa000510.42583138
95Pyrimidine metabolism_Homo sapiens_hsa002400.41162613
96Linoleic acid metabolism_Homo sapiens_hsa005910.40007426
97Oocyte meiosis_Homo sapiens_hsa041140.39377540
98alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.39188502
99Circadian rhythm_Homo sapiens_hsa047100.38836453
100Olfactory transduction_Homo sapiens_hsa047400.37859891
101Proteasome_Homo sapiens_hsa030500.31395481
102Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.25902627
103Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.24314488
104p53 signaling pathway_Homo sapiens_hsa041150.23238919
105Arachidonic acid metabolism_Homo sapiens_hsa005900.21862606
106Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.21265367
107* Protein export_Homo sapiens_hsa030600.19856245
108Ether lipid metabolism_Homo sapiens_hsa005650.14672493
109Purine metabolism_Homo sapiens_hsa002300.12104673
110Glycerophospholipid metabolism_Homo sapiens_hsa005640.09003208
111Glucagon signaling pathway_Homo sapiens_hsa049220.08411281
112Adipocytokine signaling pathway_Homo sapiens_hsa049200.06994325
113Cardiac muscle contraction_Homo sapiens_hsa042600.02351037
114Base excision repair_Homo sapiens_hsa03410-0.1018129
115AMPK signaling pathway_Homo sapiens_hsa04152-0.0934711
116Homologous recombination_Homo sapiens_hsa03440-0.0856688
117RNA polymerase_Homo sapiens_hsa03020-0.0648197
118Systemic lupus erythematosus_Homo sapiens_hsa05322-0.0630682
119Prion diseases_Homo sapiens_hsa05020-0.0520733
120DNA replication_Homo sapiens_hsa03030-0.0482591
121Insulin resistance_Homo sapiens_hsa04931-0.0415846
122Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623-0.0373863
123Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563-0.0355579
124Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970-0.0014746

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