IMMTP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1detection of light stimulus involved in sensory perception (GO:0050962)5.52454315
2detection of light stimulus involved in visual perception (GO:0050908)5.52454315
3negative regulation of execution phase of apoptosis (GO:1900118)4.70683791
4ribonucleoprotein complex disassembly (GO:0032988)4.55525716
5neural tube formation (GO:0001841)4.13434807
6mitochondrial respiratory chain complex I assembly (GO:0032981)4.10513290
7NADH dehydrogenase complex assembly (GO:0010257)4.10513290
8mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.10513290
9ubiquinone biosynthetic process (GO:0006744)4.08223235
10ubiquinone metabolic process (GO:0006743)4.05459197
11respiratory chain complex IV assembly (GO:0008535)3.86748313
12protein complex biogenesis (GO:0070271)3.85629259
13negative regulation of telomere maintenance (GO:0032205)3.85368664
14fucose catabolic process (GO:0019317)3.83132967
15L-fucose metabolic process (GO:0042354)3.83132967
16L-fucose catabolic process (GO:0042355)3.83132967
17piRNA metabolic process (GO:0034587)3.80915716
18behavioral response to nicotine (GO:0035095)3.76724334
19regulation of type B pancreatic cell apoptotic process (GO:2000674)3.73680396
20rRNA catabolic process (GO:0016075)3.68456521
21ribosomal small subunit assembly (GO:0000028)3.65652417
22protein-cofactor linkage (GO:0018065)3.64722624
23membrane depolarization during action potential (GO:0086010)3.63801030
24regulation of cilium movement (GO:0003352)3.60578599
25reflex (GO:0060004)3.54151967
26epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.51320246
27regulation of cytokine production involved in inflammatory response (GO:1900015)3.50064532
28water-soluble vitamin biosynthetic process (GO:0042364)3.47351095
29kidney morphogenesis (GO:0060993)3.45791165
30somite rostral/caudal axis specification (GO:0032525)3.43667299
31calcium ion import (GO:0070509)3.41656705
32mitochondrial respiratory chain complex assembly (GO:0033108)3.39309742
33quinone biosynthetic process (GO:1901663)3.30923207
34regulation of protein kinase A signaling (GO:0010738)3.30534549
35cAMP catabolic process (GO:0006198)3.29935152
36cellular response to ATP (GO:0071318)3.27677302
37mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.24403908
38neurofilament cytoskeleton organization (GO:0060052)3.22399475
39negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.20437430
40negative regulation of translation, ncRNA-mediated (GO:0040033)3.20437430
41regulation of translation, ncRNA-mediated (GO:0045974)3.20437430
42cyclic nucleotide catabolic process (GO:0009214)3.18147819
43protein polyglutamylation (GO:0018095)3.12404517
44regulation of hexokinase activity (GO:1903299)3.10133165
45regulation of glucokinase activity (GO:0033131)3.10133165
46regulation of action potential (GO:0098900)3.08501426
47mitochondrial calcium ion homeostasis (GO:0051560)3.04256624
48positive regulation of TOR signaling (GO:0032008)3.03959384
49regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.98441852
50somatic hypermutation of immunoglobulin genes (GO:0016446)2.97065408
51somatic diversification of immune receptors via somatic mutation (GO:0002566)2.97065408
52phosphorylated carbohydrate dephosphorylation (GO:0046838)2.94085657
53inositol phosphate dephosphorylation (GO:0046855)2.94085657
54multicellular organismal movement (GO:0050879)2.92203749
55musculoskeletal movement (GO:0050881)2.92203749
56membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.91431901
57spliceosomal complex assembly (GO:0000245)2.90565923
58righting reflex (GO:0060013)2.90407583
59mannosylation (GO:0097502)2.89866412
60cGMP metabolic process (GO:0046068)2.86446909
61dopaminergic neuron differentiation (GO:0071542)2.86166616
62regulation of glycogen (starch) synthase activity (GO:2000465)2.81766572
63inositol phosphate catabolic process (GO:0071545)2.76182686
64lens development in camera-type eye (GO:0002088)2.75193885
65organelle disassembly (GO:1903008)2.73490902
66indolalkylamine metabolic process (GO:0006586)2.72079822
67cytochrome complex assembly (GO:0017004)2.68804963
68regulation of telomere maintenance (GO:0032204)2.67675132
69RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.67570288
70polyol catabolic process (GO:0046174)2.67154556
71negative regulation of meiosis (GO:0045835)2.65052022
72primary amino compound metabolic process (GO:1901160)2.64469047
73establishment of mitochondrion localization (GO:0051654)2.64405916
74embryonic epithelial tube formation (GO:0001838)2.63787592
75protein neddylation (GO:0045116)2.63744072
76peptidyl-histidine modification (GO:0018202)2.63213728
77regulation of cAMP-mediated signaling (GO:0043949)2.62530768
78establishment of protein localization to Golgi (GO:0072600)2.59556620
79ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:0043162.58861251
80spinal cord motor neuron differentiation (GO:0021522)2.58411385
81response to gravity (GO:0009629)2.58234677
82neuron fate specification (GO:0048665)2.57314244
83protein localization to Golgi apparatus (GO:0034067)2.55731390
84inner ear receptor cell differentiation (GO:0060113)2.55477459
85regulation of interleukin-6 biosynthetic process (GO:0045408)2.53455288
86DNA deamination (GO:0045006)2.53095068
87magnesium ion transport (GO:0015693)2.52884292
88serotonin metabolic process (GO:0042428)2.52337264
89protein localization to cilium (GO:0061512)2.52134313
90pseudouridine synthesis (GO:0001522)2.51555729
91negative regulation of cytosolic calcium ion concentration (GO:0051481)2.50310678
92gene silencing by RNA (GO:0031047)2.49633908
93respiratory electron transport chain (GO:0022904)2.49611543
94base-excision repair, AP site formation (GO:0006285)2.49530527
95electron transport chain (GO:0022900)2.48548644
96regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)2.48248266
97nonmotile primary cilium assembly (GO:0035058)2.47718573
98dorsal/ventral neural tube patterning (GO:0021904)2.47468063
99regulation of meiosis I (GO:0060631)2.47232403
100epithelial tube formation (GO:0072175)2.46777839

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RBPJ_22232070_ChIP-Seq_NCS_Mouse4.01551411
2VDR_22108803_ChIP-Seq_LS180_Human3.77621586
3FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.66643045
4E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.60327174
5EZH2_22144423_ChIP-Seq_EOC_Human3.57812525
6GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.83250097
7ZNF274_21170338_ChIP-Seq_K562_Hela2.63215513
8GABP_17652178_ChIP-ChIP_JURKAT_Human2.50610472
9GBX2_23144817_ChIP-Seq_PC3_Human2.37456995
10HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.31796298
11FLI1_27457419_Chip-Seq_LIVER_Mouse2.25743708
12GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.25566163
13FUS_26573619_Chip-Seq_HEK293_Human2.19676059
14KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.18055756
15EWS_26573619_Chip-Seq_HEK293_Human2.11915603
16IRF1_19129219_ChIP-ChIP_H3396_Human2.11709848
17EST1_17652178_ChIP-ChIP_JURKAT_Human2.07438377
18CTBP2_25329375_ChIP-Seq_LNCAP_Human1.99521291
19SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.93066960
20PCGF2_27294783_Chip-Seq_ESCs_Mouse1.92407243
21POU5F1_16153702_ChIP-ChIP_HESCs_Human1.86143419
22ZFP57_27257070_Chip-Seq_ESCs_Mouse1.85605394
23NOTCH1_21737748_ChIP-Seq_TLL_Human1.81972061
24CTBP1_25329375_ChIP-Seq_LNCAP_Human1.80661739
25POU3F2_20337985_ChIP-ChIP_501MEL_Human1.77609556
26CBX2_27304074_Chip-Seq_ESCs_Mouse1.77248608
27IGF1R_20145208_ChIP-Seq_DFB_Human1.75262280
28BMI1_23680149_ChIP-Seq_NPCS_Mouse1.73284257
29EED_16625203_ChIP-ChIP_MESCs_Mouse1.73048097
30JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.71343761
31ETS1_20019798_ChIP-Seq_JURKAT_Human1.70961644
32P300_19829295_ChIP-Seq_ESCs_Human1.62289050
33REST_21632747_ChIP-Seq_MESCs_Mouse1.59157034
34NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.58704678
35CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.55731344
36PCGF2_27294783_Chip-Seq_NPCs_Mouse1.50595408
37VDR_23849224_ChIP-Seq_CD4+_Human1.49578670
38EZH2_27304074_Chip-Seq_ESCs_Mouse1.44937703
39ER_23166858_ChIP-Seq_MCF-7_Human1.43667996
40TAF15_26573619_Chip-Seq_HEK293_Human1.43420771
41MYC_18940864_ChIP-ChIP_HL60_Human1.35277651
42RNF2_27304074_Chip-Seq_NSC_Mouse1.34837796
43SUZ12_27294783_Chip-Seq_NPCs_Mouse1.34509482
44EZH2_27294783_Chip-Seq_NPCs_Mouse1.34485930
45MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.34131581
46TP53_22573176_ChIP-Seq_HFKS_Human1.32171232
47SOX2_18555785_ChIP-Seq_MESCs_Mouse1.28562037
48PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.27625745
49EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.27367448
50TDRD3_21172665_ChIP-Seq_MCF-7_Human1.21183039
51NFE2_27457419_Chip-Seq_LIVER_Mouse1.17724108
52PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.12645864
53REST_18959480_ChIP-ChIP_MESCs_Mouse1.12408557
54PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.11438594
55SMAD4_21799915_ChIP-Seq_A2780_Human1.10806146
56SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.08716744
57RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.07752287
58FLI1_21867929_ChIP-Seq_TH2_Mouse1.07719612
59EZH2_27294783_Chip-Seq_ESCs_Mouse1.07352015
60BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.06974592
61NANOG_19829295_ChIP-Seq_ESCs_Human1.06434085
62SOX2_19829295_ChIP-Seq_ESCs_Human1.06434085
63STAT3_23295773_ChIP-Seq_U87_Human1.06171899
64THAP11_20581084_ChIP-Seq_MESCs_Mouse1.02888861
65UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.01115204
66MYC_19829295_ChIP-Seq_ESCs_Human1.01074066
67MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.00928684
68CRX_20693478_ChIP-Seq_RETINA_Mouse1.00811297
69JARID2_20064375_ChIP-Seq_MESCs_Mouse1.00350986
70TCF4_23295773_ChIP-Seq_U87_Human1.00191135
71GATA3_21878914_ChIP-Seq_MCF-7_Human0.98840921
72SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.98255099
73TOP2B_26459242_ChIP-Seq_MCF-7_Human0.97876050
74EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.96745607
75AR_20517297_ChIP-Seq_VCAP_Human0.96664842
76CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.96487523
77SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.96160592
78GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.94955257
79POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.94251224
80SRF_21415370_ChIP-Seq_HL-1_Mouse0.94156285
81SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.93871976
82FOXA1_27270436_Chip-Seq_PROSTATE_Human0.93550255
83FOXA1_25329375_ChIP-Seq_VCAP_Human0.93550255
84CBP_20019798_ChIP-Seq_JUKART_Human0.92892457
85IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.92892457
86SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.91773796
87SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.91558876
88EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.89300256
89CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.89015422
90TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.86781889
91E2F1_18555785_Chip-Seq_ESCs_Mouse0.86648672
92KDM2B_26808549_Chip-Seq_REH_Human0.86618329
93NANOG_18555785_Chip-Seq_ESCs_Mouse0.86044001
94P53_22387025_ChIP-Seq_ESCs_Mouse0.86007657
95MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.85486541
96SALL1_21062744_ChIP-ChIP_HESCs_Human0.85108630
97TAL1_26923725_Chip-Seq_HPCs_Mouse0.84916813
98AR_21572438_ChIP-Seq_LNCaP_Human0.84195487
99SMAD3_21741376_ChIP-Seq_EPCs_Human0.84019137
100AR_25329375_ChIP-Seq_VCAP_Human0.83626718

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005645_abnormal_hypothalamus_physiol3.08405947
2MP0002277_abnormal_respiratory_mucosa3.00942681
3MP0002638_abnormal_pupillary_reflex2.93160220
4MP0002822_catalepsy2.75184111
5MP0004145_abnormal_muscle_electrophysio2.70441094
6MP0008877_abnormal_DNA_methylation2.59492716
7MP0005646_abnormal_pituitary_gland2.48120212
8MP0003646_muscle_fatigue2.46213124
9MP0001984_abnormal_olfaction2.46172937
10MP0001905_abnormal_dopamine_level2.38428915
11MP0001986_abnormal_taste_sensitivity2.23274306
12MP0006072_abnormal_retinal_apoptosis2.23164064
13MP0009046_muscle_twitch2.20417248
14MP0000566_synostosis2.17952794
15MP0003136_yellow_coat_color2.14643773
16MP0002735_abnormal_chemical_nociception2.13280434
17MP0004142_abnormal_muscle_tone2.10914029
18MP0006276_abnormal_autonomic_nervous2.07331086
19MP0008995_early_reproductive_senescence2.01037280
20MP0002736_abnormal_nociception_after1.92046119
21MP0002733_abnormal_thermal_nociception1.91069023
22MP0001968_abnormal_touch/_nociception1.87668286
23MP0002876_abnormal_thyroid_physiology1.83674782
24MP0000372_irregular_coat_pigmentation1.82229192
25MP0004133_heterotaxia1.70273798
26MP0008058_abnormal_DNA_repair1.69531203
27MP0009745_abnormal_behavioral_response1.68839401
28MP0002837_dystrophic_cardiac_calcinosis1.67414537
29MP0005551_abnormal_eye_electrophysiolog1.61481915
30MP0002734_abnormal_mechanical_nocicepti1.56538868
31MP0008872_abnormal_physiological_respon1.56358098
32MP0002909_abnormal_adrenal_gland1.54906367
33MP0001501_abnormal_sleep_pattern1.54499461
34MP0003122_maternal_imprinting1.54163659
35MP0003786_premature_aging1.52949520
36MP0004270_analgesia1.52272961
37MP0002572_abnormal_emotion/affect_behav1.51692379
38MP0006035_abnormal_mitochondrial_morpho1.50434144
39MP0006292_abnormal_olfactory_placode1.50133325
40MP0001485_abnormal_pinna_reflex1.48439255
41MP0002557_abnormal_social/conspecific_i1.46969220
42MP0002272_abnormal_nervous_system1.46225686
43MP0005253_abnormal_eye_physiology1.43704419
44MP0001970_abnormal_pain_threshold1.40387878
45MP0002938_white_spotting1.38287201
46MP0008775_abnormal_heart_ventricle1.37377145
47MP0002064_seizures1.36923975
48MP0001502_abnormal_circadian_rhythm1.36408859
49MP0000631_abnormal_neuroendocrine_gland1.35732106
50MP0001529_abnormal_vocalization1.34169369
51MP0003787_abnormal_imprinting1.28041136
52MP0003880_abnormal_central_pattern1.27772080
53MP0002184_abnormal_innervation1.21900688
54MP0005394_taste/olfaction_phenotype1.21345462
55MP0005499_abnormal_olfactory_system1.21345462
56MP0002234_abnormal_pharynx_morphology1.19819498
57MP0003718_maternal_effect1.18265151
58MP0002693_abnormal_pancreas_physiology1.16609160
59MP0003890_abnormal_embryonic-extraembry1.16567017
60MP0008789_abnormal_olfactory_epithelium1.15795833
61MP0003119_abnormal_digestive_system1.11446573
62MP0004147_increased_porphyrin_level1.10490244
63MP0003959_abnormal_lean_body1.04860467
64MP0002067_abnormal_sensory_capabilities1.04494517
65MP0002063_abnormal_learning/memory/cond1.04013564
66MP0003879_abnormal_hair_cell1.03042739
67MP0005386_behavior/neurological_phenoty1.00382953
68MP0004924_abnormal_behavior1.00382953
69MP0003121_genomic_imprinting0.98193545
70MP0000778_abnormal_nervous_system0.96248699
71MP0003195_calcinosis0.94171122
72MP0002138_abnormal_hepatobiliary_system0.94031784
73MP0003806_abnormal_nucleotide_metabolis0.91784512
74MP0001188_hyperpigmentation0.90780301
75MP0004043_abnormal_pH_regulation0.88580556
76MP0002095_abnormal_skin_pigmentation0.88421760
77MP0002089_abnormal_postnatal_growth/wei0.87177423
78MP0001944_abnormal_pancreas_morphology0.86812981
79MP0003693_abnormal_embryo_hatching0.84277441
80MP0008961_abnormal_basal_metabolism0.84193054
81MP0003635_abnormal_synaptic_transmissio0.82707752
82MP0005391_vision/eye_phenotype0.82442360
83MP0002229_neurodegeneration0.82207290
84MP0009379_abnormal_foot_pigmentation0.82001345
85MP0008875_abnormal_xenobiotic_pharmacok0.80677556
86MP0005084_abnormal_gallbladder_morpholo0.80553238
87MP0000955_abnormal_spinal_cord0.79070070
88MP0002752_abnormal_somatic_nervous0.78370783
89MP0005195_abnormal_posterior_eye0.78247552
90MP0004885_abnormal_endolymph0.76951913
91MP0000685_abnormal_immune_system0.76596827
92MP0000639_abnormal_adrenal_gland0.76287820
93MP0008569_lethality_at_weaning0.76206949
94MP0001486_abnormal_startle_reflex0.75299937
95MP0001440_abnormal_grooming_behavior0.74916538
96MP0004811_abnormal_neuron_physiology0.72791697
97MP0002882_abnormal_neuron_morphology0.71958609
98MP0001764_abnormal_homeostasis0.70159288
99MP0005266_abnormal_metabolism0.69584580
100MP0003943_abnormal_hepatobiliary_system0.68519375

Predicted human phenotypes

RankGene SetZ-score
1Congenital stationary night blindness (HP:0007642)6.42008966
2Aplasia/Hypoplasia of the fovea (HP:0008060)4.78302938
3Hypoplasia of the fovea (HP:0007750)4.78302938
4Abnormal rod and cone electroretinograms (HP:0008323)4.45895971
5Abnormality of the fovea (HP:0000493)3.95634749
6Severe visual impairment (HP:0001141)3.91216632
7Abnormality of macular pigmentation (HP:0008002)3.67119794
8Tubulointerstitial nephritis (HP:0001970)3.60021969
9Thyroid-stimulating hormone excess (HP:0002925)3.48029773
10Colon cancer (HP:0003003)3.37049393
11Central scotoma (HP:0000603)3.33029119
12Renal cortical cysts (HP:0000803)3.31111328
13Hepatic necrosis (HP:0002605)3.28138189
14Medial flaring of the eyebrow (HP:0010747)2.99556826
15Acute necrotizing encephalopathy (HP:0006965)2.99097969
16Nephronophthisis (HP:0000090)2.85704132
17Hypoglycemic coma (HP:0001325)2.85558496
18Generalized aminoaciduria (HP:0002909)2.84801009
19Agitation (HP:0000713)2.81391030
20Gaze-evoked nystagmus (HP:0000640)2.81234158
21Abnormality of the labia minora (HP:0012880)2.78038807
22Aplasia/Hypoplasia of the macula (HP:0008059)2.75761595
23Abnormality of the renal cortex (HP:0011035)2.73184045
24Limb dystonia (HP:0002451)2.70613360
25Hypothermia (HP:0002045)2.67228732
26Increased CSF lactate (HP:0002490)2.66095095
27Abnormal mitochondria in muscle tissue (HP:0008316)2.65851464
28Genetic anticipation (HP:0003743)2.63997621
29Progressive macrocephaly (HP:0004481)2.54820664
30Aplasia/Hypoplasia affecting the retina (HP:0008061)2.53182953
31Mitochondrial inheritance (HP:0001427)2.52291342
32Hepatocellular necrosis (HP:0001404)2.50691755
33Molar tooth sign on MRI (HP:0002419)2.48653236
34Abnormality of midbrain morphology (HP:0002418)2.48653236
35Scotoma (HP:0000575)2.46480106
36Nephrogenic diabetes insipidus (HP:0009806)2.46324107
37Tubular atrophy (HP:0000092)2.44677990
38Acute encephalopathy (HP:0006846)2.39950404
39Reticulocytopenia (HP:0001896)2.36120238
40Absent thumb (HP:0009777)2.30407644
41Abnormality of the renal medulla (HP:0100957)2.27157718
42Attenuation of retinal blood vessels (HP:0007843)2.26729369
43Gait imbalance (HP:0002141)2.21096185
44Progressive cerebellar ataxia (HP:0002073)2.19901350
45Albinism (HP:0001022)2.19857597
46IgG deficiency (HP:0004315)2.15360226
47Aplasia/Hypoplasia of the tibia (HP:0005772)2.14478776
48Tubulointerstitial abnormality (HP:0001969)2.13883741
49Congenital primary aphakia (HP:0007707)2.13601259
50CNS hypomyelination (HP:0003429)2.10209052
51Pancreatic fibrosis (HP:0100732)2.06694063
52Stomatitis (HP:0010280)2.05207493
53Severe muscular hypotonia (HP:0006829)2.02315047
54Rib fusion (HP:0000902)2.01420996
55Cerebral hypomyelination (HP:0006808)1.97503053
56Constricted visual fields (HP:0001133)1.96243613
57Type II lissencephaly (HP:0007260)1.96181231
58Hemiparesis (HP:0001269)1.95341691
59Acute lymphatic leukemia (HP:0006721)1.94075625
60Bony spicule pigmentary retinopathy (HP:0007737)1.92902558
61IgA deficiency (HP:0002720)1.91821943
62Failure to thrive in infancy (HP:0001531)1.90694764
63Pancreatic cysts (HP:0001737)1.89839523
64Abnormality of the renal collecting system (HP:0004742)1.88807690
65Methylmalonic acidemia (HP:0002912)1.88118896
66Astigmatism (HP:0000483)1.87821721
67Abolished electroretinogram (ERG) (HP:0000550)1.87813296
68Poor coordination (HP:0002370)1.87039831
69Genital tract atresia (HP:0001827)1.86788832
70Supernumerary spleens (HP:0009799)1.85408131
71Short tibia (HP:0005736)1.83291292
72Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.80474216
73Abnormality of alanine metabolism (HP:0010916)1.80474216
74Hyperalaninemia (HP:0003348)1.80474216
75Abnormal drinking behavior (HP:0030082)1.79514258
76Polydipsia (HP:0001959)1.79514258
77Vaginal atresia (HP:0000148)1.77968220
78Duplicated collecting system (HP:0000081)1.76721451
79Increased serum lactate (HP:0002151)1.76492244
80Renovascular hypertension (HP:0100817)1.76187982
81Glycosuria (HP:0003076)1.75550878
82Abnormality of urine glucose concentration (HP:0011016)1.75550878
83Abnormality of the ileum (HP:0001549)1.75471591
84Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.74890699
85Hyperglycinemia (HP:0002154)1.74840900
86Aplasia/Hypoplasia of the uvula (HP:0010293)1.74524413
87Restlessness (HP:0000711)1.73758164
88Inability to walk (HP:0002540)1.72442072
89Cerebral edema (HP:0002181)1.71698482
90Optic nerve hypoplasia (HP:0000609)1.69699100
91Lethargy (HP:0001254)1.68092239
92Meckel diverticulum (HP:0002245)1.67186558
93Abnormality of the carotid arteries (HP:0005344)1.66140121
94Ectopic kidney (HP:0000086)1.65708799
95Chromsome breakage (HP:0040012)1.64436227
96Pachygyria (HP:0001302)1.62868505
97Abnormality of chromosome stability (HP:0003220)1.60899643
98Abnormal respiratory epithelium morphology (HP:0012253)1.59996523
99Abnormal respiratory motile cilium morphology (HP:0005938)1.59996523
100Chorioretinal atrophy (HP:0000533)1.58735235

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK5.26876061
2ZAK2.75456156
3MKNK12.59976466
4NME22.52282540
5CASK2.38175069
6TLK12.31757554
7BCKDK2.30268279
8CSNK1G32.28745924
9WNK32.28628068
10WNK42.18897391
11PNCK2.09724379
12CSNK1G22.05534431
13MAPKAPK52.00858789
14NUAK11.99198012
15GRK11.98951688
16TSSK61.98572269
17CSNK1G11.92395027
18PHKG21.90853807
19PHKG11.90853807
20ADRBK21.85688875
21STK391.84747342
22TRIM281.64909105
23CSNK1A1L1.61481693
24TAOK31.47970468
25TIE11.39458532
26PAK31.34035438
27MAP2K21.29709360
28DYRK21.22013228
29MAP4K21.20973226
30CCNB11.19241964
31PINK11.18992223
32CSNK1E1.18973501
33PDK21.14630561
34PRKCG1.07676622
35TNK21.07315102
36MAPK131.05663518
37MAP3K121.03892327
38CDC71.03878809
39ACVR1B0.96263075
40MAPKAPK30.93388040
41SRPK10.90353974
42INSRR0.88683147
43VRK10.86988766
44MAP2K60.85629115
45RPS6KA50.83353904
46TRPM70.81034085
47PIK3CA0.81010181
48CHUK0.80677961
49MAP3K90.80271514
50PRKCH0.80086206
51IKBKB0.74570226
52RPS6KB10.73465459
53CAMKK20.71372754
54ADRBK10.69934063
55MAP3K40.68855916
56STK38L0.68270502
57WEE10.67341673
58MARK10.66876495
59CAMK2A0.65820546
60CAMK10.65705395
61FGFR20.63390300
62PRKACA0.62802589
63PRKAA10.62562191
64PRKCQ0.60454983
65CSNK1A10.57798827
66PRKAA20.57215461
67BMPR1B0.56048957
68WNK10.55984115
69ATR0.55668563
70GRK70.55340828
71MAP3K130.54682225
72GRK50.52520946
73FES0.52122448
74PLK30.51715317
75AURKA0.50233199
76CSNK2A20.49037183
77CAMK40.48650456
78PRKCB0.48531348
79PLK10.48249891
80OBSCN0.47144366
81ATM0.45790061
82SGK10.44446542
83MKNK20.43237399
84CHEK20.42406715
85DAPK10.42386198
86PRKG10.42230936
87STK110.40432753
88PRKCA0.40379627
89CAMKK10.40238905
90BCR0.39655555
91PRKACB0.38796017
92NEK10.38131620
93TXK0.38124654
94CSNK1D0.37646566
95DAPK20.37303472
96PRKCZ0.35126328
97VRK20.34435025
98MATK0.34005905
99OXSR10.33198340
100STK240.32273447

Predicted pathways (KEGG)

RankGene SetZ-score
1Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001303.09061039
2Maturity onset diabetes of the young_Homo sapiens_hsa049502.85694158
3Oxidative phosphorylation_Homo sapiens_hsa001902.76832062
4Parkinsons disease_Homo sapiens_hsa050122.37833252
5Ribosome_Homo sapiens_hsa030102.37188007
6Protein export_Homo sapiens_hsa030602.08045194
7Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.98632412
8Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.97171449
9Cardiac muscle contraction_Homo sapiens_hsa042601.95680338
10Basal transcription factors_Homo sapiens_hsa030221.92272250
11Primary bile acid biosynthesis_Homo sapiens_hsa001201.90848466
12Proteasome_Homo sapiens_hsa030501.84654146
13Sulfur metabolism_Homo sapiens_hsa009201.80482397
14Phototransduction_Homo sapiens_hsa047441.80218868
15RNA degradation_Homo sapiens_hsa030181.78382940
16Morphine addiction_Homo sapiens_hsa050321.74714870
17Fanconi anemia pathway_Homo sapiens_hsa034601.63594620
18Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.63111803
19Alzheimers disease_Homo sapiens_hsa050101.62824685
20Insulin secretion_Homo sapiens_hsa049111.61635851
21Nicotine addiction_Homo sapiens_hsa050331.59356302
22Serotonergic synapse_Homo sapiens_hsa047261.57996504
23Butanoate metabolism_Homo sapiens_hsa006501.51772770
24Homologous recombination_Homo sapiens_hsa034401.51740242
25Intestinal immune network for IgA production_Homo sapiens_hsa046721.49855307
26GABAergic synapse_Homo sapiens_hsa047271.48727175
27Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.45720367
28Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.41455303
29alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.41039930
30Spliceosome_Homo sapiens_hsa030401.39646441
31Non-homologous end-joining_Homo sapiens_hsa034501.39198575
32Linoleic acid metabolism_Homo sapiens_hsa005911.38541639
33Huntingtons disease_Homo sapiens_hsa050161.36989163
34Cyanoamino acid metabolism_Homo sapiens_hsa004601.35656373
35Base excision repair_Homo sapiens_hsa034101.35024838
36RNA polymerase_Homo sapiens_hsa030201.29359526
37Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.28107021
38One carbon pool by folate_Homo sapiens_hsa006701.25744841
39Cysteine and methionine metabolism_Homo sapiens_hsa002701.20231426
40Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.19799692
41Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.18438768
42Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.18133525
43Peroxisome_Homo sapiens_hsa041461.12118676
44Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.07128661
45Sulfur relay system_Homo sapiens_hsa041221.06160285
46Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.04553879
47Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.04341387
48Tryptophan metabolism_Homo sapiens_hsa003801.02964526
49Regulation of autophagy_Homo sapiens_hsa041400.99649072
50Nucleotide excision repair_Homo sapiens_hsa034200.99595779
51Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.99338308
52Taste transduction_Homo sapiens_hsa047420.97293101
53Dopaminergic synapse_Homo sapiens_hsa047280.93076789
54Steroid hormone biosynthesis_Homo sapiens_hsa001400.88942272
55Nitrogen metabolism_Homo sapiens_hsa009100.88538745
56Circadian entrainment_Homo sapiens_hsa047130.88445276
57Cholinergic synapse_Homo sapiens_hsa047250.87163722
58Purine metabolism_Homo sapiens_hsa002300.86576884
59Circadian rhythm_Homo sapiens_hsa047100.85721947
60RNA transport_Homo sapiens_hsa030130.84751077
61Glutamatergic synapse_Homo sapiens_hsa047240.80759446
62Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.78980723
63Ether lipid metabolism_Homo sapiens_hsa005650.77272393
64Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.75035315
65Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.73755285
66Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.71631038
67Steroid biosynthesis_Homo sapiens_hsa001000.70339792
68Propanoate metabolism_Homo sapiens_hsa006400.69217562
69Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.67895748
70Type I diabetes mellitus_Homo sapiens_hsa049400.67813478
71Ovarian steroidogenesis_Homo sapiens_hsa049130.67747272
72Asthma_Homo sapiens_hsa053100.67693390
73Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.67282152
74Fatty acid biosynthesis_Homo sapiens_hsa000610.65748987
75Fatty acid elongation_Homo sapiens_hsa000620.64464740
76Folate biosynthesis_Homo sapiens_hsa007900.63301518
77Metabolic pathways_Homo sapiens_hsa011000.62399089
78Phenylalanine metabolism_Homo sapiens_hsa003600.60875144
79SNARE interactions in vesicular transport_Homo sapiens_hsa041300.58480789
80Retinol metabolism_Homo sapiens_hsa008300.56260392
81Aldosterone synthesis and secretion_Homo sapiens_hsa049250.55476910
82Fatty acid metabolism_Homo sapiens_hsa012120.54306207
83Calcium signaling pathway_Homo sapiens_hsa040200.52806344
84Selenocompound metabolism_Homo sapiens_hsa004500.52777200
85Primary immunodeficiency_Homo sapiens_hsa053400.52687337
86Renin secretion_Homo sapiens_hsa049240.51976980
87Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.49694806
88Oxytocin signaling pathway_Homo sapiens_hsa049210.46372185
89Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.44921378
90Fat digestion and absorption_Homo sapiens_hsa049750.43680294
91Systemic lupus erythematosus_Homo sapiens_hsa053220.43073002
92Chemical carcinogenesis_Homo sapiens_hsa052040.41915230
93Pyrimidine metabolism_Homo sapiens_hsa002400.40766811
942-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.40530356
95Arginine and proline metabolism_Homo sapiens_hsa003300.40393047
96Vitamin digestion and absorption_Homo sapiens_hsa049770.38761929
97Vascular smooth muscle contraction_Homo sapiens_hsa042700.38248457
98Cocaine addiction_Homo sapiens_hsa050300.38240023
99Amphetamine addiction_Homo sapiens_hsa050310.38064417
100Salivary secretion_Homo sapiens_hsa049700.36598974

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