IMP3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes the human homolog of the yeast Imp3 protein. The protein localizes to the nucleoli and interacts with the U3 snoRNP complex. The protein contains an S4 domain. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)7.40880753
2viral transcription (GO:0019083)7.38203514
3translational termination (GO:0006415)7.19252026
4ribosomal small subunit biogenesis (GO:0042274)6.95484352
5SRP-dependent cotranslational protein targeting to membrane (GO:0006614)6.34567024
6DNA deamination (GO:0045006)6.32740734
7cotranslational protein targeting to membrane (GO:0006613)6.24333074
8translational elongation (GO:0006414)6.24058258
9protein targeting to ER (GO:0045047)6.22138435
10maturation of SSU-rRNA (GO:0030490)6.10411550
11establishment of protein localization to endoplasmic reticulum (GO:0072599)5.94168529
12protein localization to endoplasmic reticulum (GO:0070972)5.92020419
13translational initiation (GO:0006413)5.60309784
14viral life cycle (GO:0019058)5.54114944
15nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)5.53455063
16cellular protein complex disassembly (GO:0043624)5.49695805
17ribosomal large subunit biogenesis (GO:0042273)5.45532698
18chaperone-mediated protein transport (GO:0072321)5.34617809
19protein complex disassembly (GO:0043241)4.77694133
20ribonucleoprotein complex biogenesis (GO:0022613)4.75620014
21translation (GO:0006412)4.57244529
22macromolecular complex disassembly (GO:0032984)4.51694218
23formation of translation preinitiation complex (GO:0001731)4.40231851
24pyrimidine nucleotide catabolic process (GO:0006244)4.24246116
25nuclear-transcribed mRNA catabolic process (GO:0000956)4.15412356
26protein targeting to membrane (GO:0006612)4.13411089
27deoxyribonucleoside monophosphate metabolic process (GO:0009162)4.12245374
28respiratory electron transport chain (GO:0022904)4.07549755
29pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.98577028
30proteasome assembly (GO:0043248)3.97909772
31protein complex biogenesis (GO:0070271)3.97450361
32electron transport chain (GO:0022900)3.96483967
33mRNA catabolic process (GO:0006402)3.94428733
34protein localization to mitochondrion (GO:0070585)3.94068665
35mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.92300279
36cellular component biogenesis (GO:0044085)3.90994193
37mitochondrial respiratory chain complex assembly (GO:0033108)3.87995857
38* rRNA processing (GO:0006364)3.87978642
39mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.83348137
40transcription elongation from RNA polymerase III promoter (GO:0006385)3.80943426
41termination of RNA polymerase III transcription (GO:0006386)3.80943426
42pseudouridine synthesis (GO:0001522)3.79411870
43* rRNA metabolic process (GO:0016072)3.74142796
44RNA catabolic process (GO:0006401)3.72022262
45ribosome biogenesis (GO:0042254)3.71466604
46DNA strand elongation involved in DNA replication (GO:0006271)3.68854478
47energy coupled proton transport, down electrochemical gradient (GO:0015985)3.66758122
48ATP synthesis coupled proton transport (GO:0015986)3.66758122
49L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.63574406
50deoxyribonucleotide catabolic process (GO:0009264)3.61904969
51protein maturation by protein folding (GO:0022417)3.61300788
52base-excision repair, AP site formation (GO:0006285)3.57610651
53nucleobase biosynthetic process (GO:0046112)3.55681926
54purine nucleobase biosynthetic process (GO:0009113)3.55399261
55deoxyribose phosphate catabolic process (GO:0046386)3.50745538
56telomere maintenance via semi-conservative replication (GO:0032201)3.49745493
57transcription from mitochondrial promoter (GO:0006390)3.49532777
58ribosome assembly (GO:0042255)3.49255159
59DNA strand elongation (GO:0022616)3.48626933
60DNA replication initiation (GO:0006270)3.47023660
61pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)3.38844055
62aerobic respiration (GO:0009060)3.36977525
63spliceosomal snRNP assembly (GO:0000387)3.33835142
64GTP biosynthetic process (GO:0006183)3.29541539
65rRNA modification (GO:0000154)3.28566658
66UTP biosynthetic process (GO:0006228)3.26319540
67RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.26109088
68tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.26109088
69negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.26011036
70mitochondrial transport (GO:0006839)3.22611119
71deoxyribonucleoside triphosphate metabolic process (GO:0009200)3.17771838
72nucleobase-containing small molecule interconversion (GO:0015949)3.14726762
73establishment of viral latency (GO:0019043)3.13758686
74protein deneddylation (GO:0000338)3.13619666
75CTP biosynthetic process (GO:0006241)3.10939852
76CTP metabolic process (GO:0046036)3.10939852
77respiratory chain complex IV assembly (GO:0008535)3.10727461
78deoxyribose phosphate biosynthetic process (GO:0046385)3.10352632
792-deoxyribonucleotide biosynthetic process (GO:0009265)3.10352632
80exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.10097729
81pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)3.09646280
82cullin deneddylation (GO:0010388)3.08921234
837-methylguanosine mRNA capping (GO:0006370)3.08417281
84DNA replication checkpoint (GO:0000076)3.06690222
85amino acid salvage (GO:0043102)3.06339272
86L-methionine salvage (GO:0071267)3.06339272
87L-methionine biosynthetic process (GO:0071265)3.06339272
88mitochondrial RNA metabolic process (GO:0000959)3.05023454
89pteridine-containing compound biosynthetic process (GO:0042559)3.03385228
90inner mitochondrial membrane organization (GO:0007007)3.03271235
91RNA capping (GO:0036260)3.03164507
927-methylguanosine RNA capping (GO:0009452)3.03164507
93peptidyl-arginine omega-N-methylation (GO:0035247)3.03095724
94positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.02856641
95maturation of 5.8S rRNA (GO:0000460)3.02808414
96negative regulation of ligase activity (GO:0051352)3.02313870
97negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.02313870
98regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.02175467
99nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.00997460
100regulation of mitochondrial translation (GO:0070129)3.00127223
101CENP-A containing nucleosome assembly (GO:0034080)2.98991484
102anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.98672642
103telomere maintenance via recombination (GO:0000722)2.96824412
104establishment of integrated proviral latency (GO:0075713)2.95736731
105establishment of protein localization to membrane (GO:0090150)2.92076965
106folic acid-containing compound biosynthetic process (GO:0009396)2.91481045
107chromatin remodeling at centromere (GO:0031055)2.91151977
108folic acid metabolic process (GO:0046655)2.89360565
109oxidative phosphorylation (GO:0006119)2.89310333
110regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.88547410
111metallo-sulfur cluster assembly (GO:0031163)2.88500323
112iron-sulfur cluster assembly (GO:0016226)2.88500323
113protein targeting (GO:0006605)2.88158083
114pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.86677477
115transcription-coupled nucleotide-excision repair (GO:0006283)2.86525999
116DNA unwinding involved in DNA replication (GO:0006268)2.86387681
117mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.86373850
118mitochondrial respiratory chain complex I assembly (GO:0032981)2.86373850
119NADH dehydrogenase complex assembly (GO:0010257)2.86373850
120guanosine-containing compound biosynthetic process (GO:1901070)2.85758621
121spliceosomal complex assembly (GO:0000245)2.85241218
122termination of RNA polymerase I transcription (GO:0006363)2.84500227
123* ncRNA processing (GO:0034470)2.83232084
124pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.82882112
125protein targeting to mitochondrion (GO:0006626)2.81491635
126DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.81081398
127ncRNA 3-end processing (GO:0043628)2.80600684
128telomere maintenance via telomere lengthening (GO:0010833)2.80465587
129transcription from RNA polymerase I promoter (GO:0006360)2.79284217
130peptidyl-histidine modification (GO:0018202)2.77875394
131establishment of protein localization to mitochondrion (GO:0072655)2.76980919
132regulation of cellular amino acid metabolic process (GO:0006521)2.76507053
133intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.76247840
134signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.76247840
135establishment of protein localization to organelle (GO:0072594)2.75698181
136establishment of protein localization to mitochondrial membrane (GO:0090151)2.74340175

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human4.58454946
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.51973880
3EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse4.03960472
4SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.95431130
5KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.64819875
6GABP_17652178_ChIP-ChIP_JURKAT_Human3.62693916
7JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.37754502
8ETS1_20019798_ChIP-Seq_JURKAT_Human3.32213913
9EST1_17652178_ChIP-ChIP_JURKAT_Human3.25099950
10* MYC_18358816_ChIP-ChIP_MESCs_Mouse3.12186660
11CREB1_15753290_ChIP-ChIP_HEK293T_Human3.04659230
12MYC_19079543_ChIP-ChIP_MESCs_Mouse2.97489755
13* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.77891571
14HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.76786646
15E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.58707512
16* XRN2_22483619_ChIP-Seq_HELA_Human2.56875622
17NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.55589912
18VDR_23849224_ChIP-Seq_CD4+_Human2.46471932
19CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.45902171
20FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.40103139
21ELF1_17652178_ChIP-ChIP_JURKAT_Human2.32449402
22DCP1A_22483619_ChIP-Seq_HELA_Human2.30974977
23* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.25353031
24E2F4_17652178_ChIP-ChIP_JURKAT_Human2.21973607
25E2F1_18555785_ChIP-Seq_MESCs_Mouse2.20549104
26SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.04856020
27GABP_19822575_ChIP-Seq_HepG2_Human2.04388921
28NELFA_20434984_ChIP-Seq_ESCs_Mouse2.03849966
29* TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.00992378
30* FOXP3_21729870_ChIP-Seq_TREG_Human1.99931500
31TTF2_22483619_ChIP-Seq_HELA_Human1.95442350
32FOXM1_23109430_ChIP-Seq_U2OS_Human1.86276372
33CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.83939386
34THAP11_20581084_ChIP-Seq_MESCs_Mouse1.82624525
35SRF_21415370_ChIP-Seq_HL-1_Mouse1.74875506
36YY1_21170310_ChIP-Seq_MESCs_Mouse1.70971155
37* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.67423211
38FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.66884225
39ZFX_18555785_ChIP-Seq_MESCs_Mouse1.65716348
40POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.63230839
41* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.61001568
42* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.60600952
43MYCN_18555785_ChIP-Seq_MESCs_Mouse1.59032646
44ELK1_19687146_ChIP-ChIP_HELA_Human1.53415412
45PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.52747133
46NOTCH1_21737748_ChIP-Seq_TLL_Human1.52369199
47ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.51466464
48HOXB4_20404135_ChIP-ChIP_EML_Mouse1.49449754
49* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.48687062
50* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.46069481
51NANOG_18555785_ChIP-Seq_MESCs_Mouse1.45657304
52PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.43255005
53AR_21909140_ChIP-Seq_LNCAP_Human1.38479394
54CIITA_25753668_ChIP-Seq_RAJI_Human1.36220650
55ELK1_22589737_ChIP-Seq_MCF10A_Human1.34904954
56KDM5A_27292631_Chip-Seq_BREAST_Human1.33294655
57E2F1_21310950_ChIP-Seq_MCF-7_Human1.25479209
58TET1_21451524_ChIP-Seq_MESCs_Mouse1.25293213
59TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.23366033
60CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.23297799
61MYC_22102868_ChIP-Seq_BL_Human1.23063233
62BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.21790918
63MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.21715429
64DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.19605289
65CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.19240913
66CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.18854779
67ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.18311102
68STAT3_1855785_ChIP-Seq_MESCs_Mouse1.18143747
69MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.15398162
70VDR_21846776_ChIP-Seq_THP-1_Human1.14114722
71POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.13845874
72ZNF263_19887448_ChIP-Seq_K562_Human1.13813364
73KLF4_18555785_ChIP-Seq_MESCs_Mouse1.12498086
74FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.08698798
75GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.06278555
76PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.05809762
77YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.05716733
78CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.05300339
79* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.04784165
80SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.04291393
81POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.03919467
82KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.03444637
83TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.03235215
84* SPI1_23547873_ChIP-Seq_NB4_Human1.03059884
85CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.02747162
86MYC_18940864_ChIP-ChIP_HL60_Human1.01808543
87SRY_22984422_ChIP-ChIP_TESTIS_Rat0.99974180
88CTCF_18555785_ChIP-Seq_MESCs_Mouse0.98690011
89TFEB_21752829_ChIP-Seq_HELA_Human0.97318005
90ELF1_20517297_ChIP-Seq_JURKAT_Human0.96856455
91HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.95991395
92HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.95976100
93SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.95726365
94ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.95335377
95GATA1_22383799_ChIP-Seq_G1ME_Mouse0.94249050
96CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.94031226
97P68_20966046_ChIP-Seq_HELA_Human0.91612615
98KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.91334923
99CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.89956969
100CTCF_26484167_Chip-Seq_Bcells_Mouse0.89625393
101BP1_19119308_ChIP-ChIP_Hs578T_Human0.88035970
102BCL6_27268052_Chip-Seq_Bcells_Human0.86874993
103FOXP1_21924763_ChIP-Seq_HESCs_Human0.86770755
104HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.85925460
105CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.85545024
106ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.83655970
107FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.83440962
108PADI4_21655091_ChIP-ChIP_MCF-7_Human0.83423135
109OCT4_18692474_ChIP-Seq_MEFs_Mouse0.83219381
110SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.82174767
111* SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.80969610
112YY1_22570637_ChIP-Seq_MALME-3M_Human0.80156541
113* TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.79696095
114SOX2_18692474_ChIP-Seq_MEFs_Mouse0.79166930

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.15538733
2MP0004957_abnormal_blastocyst_morpholog4.20173219
3MP0009379_abnormal_foot_pigmentation3.54530912
4MP0003806_abnormal_nucleotide_metabolis3.08559243
5MP0003077_abnormal_cell_cycle3.07661400
6MP0010094_abnormal_chromosome_stability2.99322897
7MP0003111_abnormal_nucleus_morphology2.81950430
8MP0002396_abnormal_hematopoietic_system2.37284717
9MP0008058_abnormal_DNA_repair2.31208487
10MP0008932_abnormal_embryonic_tissue2.22539955
11MP0003186_abnormal_redox_activity2.21554721
12MP0008057_abnormal_DNA_replication2.18533784
13MP0008007_abnormal_cellular_replicative2.11932225
14MP0009333_abnormal_splenocyte_physiolog2.08653962
15MP0000490_abnormal_crypts_of2.03775756
16MP0003718_maternal_effect2.01253427
17MP0009840_abnormal_foam_cell2.00724760
18MP0006036_abnormal_mitochondrial_physio1.94017610
19MP0003786_premature_aging1.90368471
20MP0002132_abnormal_respiratory_system1.83579468
21MP0005084_abnormal_gallbladder_morpholo1.76075490
22MP0001730_embryonic_growth_arrest1.75660727
23MP0004147_increased_porphyrin_level1.60869680
24MP0003763_abnormal_thymus_physiology1.53346820
25MP0002160_abnormal_reproductive_system1.49847255
26MP0005394_taste/olfaction_phenotype1.47027013
27MP0005499_abnormal_olfactory_system1.47027013
28MP0000372_irregular_coat_pigmentation1.45184388
29MP0000350_abnormal_cell_proliferation1.43361376
30MP0002234_abnormal_pharynx_morphology1.43329321
31MP0001545_abnormal_hematopoietic_system1.42517472
32MP0005397_hematopoietic_system_phenotyp1.42517472
33MP0002796_impaired_skin_barrier1.41357897
34MP0001905_abnormal_dopamine_level1.39003316
35MP0002163_abnormal_gland_morphology1.37728814
36MP0005408_hypopigmentation1.35981091
37MP0001188_hyperpigmentation1.32778739
38MP0006292_abnormal_olfactory_placode1.32122557
39MP0003123_paternal_imprinting1.31963632
40MP0005451_abnormal_body_composition1.31520447
41MP0003656_abnormal_erythrocyte_physiolo1.31012837
42MP0002019_abnormal_tumor_incidence1.29985425
43MP0009697_abnormal_copulation1.28887824
44MP0005645_abnormal_hypothalamus_physiol1.28347797
45MP0004808_abnormal_hematopoietic_stem1.27596020
46MP0003315_abnormal_perineum_morphology1.24998505
47MP0010030_abnormal_orbit_morphology1.23699872
48MP0000313_abnormal_cell_death1.22702874
49MP0005083_abnormal_biliary_tract1.21914462
50MP0002822_catalepsy1.19044381
51MP0003221_abnormal_cardiomyocyte_apopto1.18779069
52MP0000685_abnormal_immune_system1.18191859
53MP0000049_abnormal_middle_ear1.17732624
54MP0002277_abnormal_respiratory_mucosa1.15969049
55MP0002722_abnormal_immune_system1.15748271
56MP0002080_prenatal_lethality1.14820270
57MP0006035_abnormal_mitochondrial_morpho1.14755021
58MP0001727_abnormal_embryo_implantation1.14183582
59MP0000689_abnormal_spleen_morphology1.13921596
60MP0002736_abnormal_nociception_after1.11861809
61MP0005220_abnormal_exocrine_pancreas1.11278565
62MP0002398_abnormal_bone_marrow1.10772717
63MP0000703_abnormal_thymus_morphology1.09956923
64MP0001697_abnormal_embryo_size1.09823564
65MP0005075_abnormal_melanosome_morpholog1.09780930
66MP0002166_altered_tumor_susceptibility1.09474511
67MP0003567_abnormal_fetal_cardiomyocyte1.05772778
68MP0000358_abnormal_cell_content/1.03641933
69MP0000465_gastrointestinal_hemorrhage1.03112611
70MP0004381_abnormal_hair_follicle1.02821732
71MP0009278_abnormal_bone_marrow1.01459933
72MP0006054_spinal_hemorrhage0.98473718
73MP0002429_abnormal_blood_cell0.97373411
74MP0002938_white_spotting0.96340794
75MP0001661_extended_life_span0.95139375
76MP0005646_abnormal_pituitary_gland0.95127473
77MP0005636_abnormal_mineral_homeostasis0.94301113
78MP0008995_early_reproductive_senescence0.93346054
79MP0001529_abnormal_vocalization0.91954660
80MP0001881_abnormal_mammary_gland0.91323033
81MP0001672_abnormal_embryogenesis/_devel0.90299823
82MP0005380_embryogenesis_phenotype0.90299823
83MP0010352_gastrointestinal_tract_polyps0.90122673
84MP0001919_abnormal_reproductive_system0.87261611
85MP0001929_abnormal_gametogenesis0.85811483
86MP0005389_reproductive_system_phenotype0.85450501
87MP0002653_abnormal_ependyma_morphology0.85371573
88MP0002638_abnormal_pupillary_reflex0.84004111
89MP0000716_abnormal_immune_system0.83981174
90MP0005671_abnormal_response_to0.81391231
91MP0001853_heart_inflammation0.80917323
92MP0000750_abnormal_muscle_regeneration0.79900734
93MP0003984_embryonic_growth_retardation0.79577591
94MP0002085_abnormal_embryonic_tissue0.79449107
95MP0002405_respiratory_system_inflammati0.78187400
96MP0003724_increased_susceptibility_to0.77692309
97MP0005330_cardiomyopathy0.77075916
98MP0005266_abnormal_metabolism0.77041307
99MP0000653_abnormal_sex_gland0.76827367
100MP0002088_abnormal_embryonic_growth/wei0.76285564
101MP0001346_abnormal_lacrimal_gland0.75725461
102MP0009785_altered_susceptibility_to0.75689059
103MP0005670_abnormal_white_adipose0.75484636
104MP0004233_abnormal_muscle_weight0.75272104
105MP0005379_endocrine/exocrine_gland_phen0.75187898
106MP0001968_abnormal_touch/_nociception0.74858978
107MP0008260_abnormal_autophagy0.74724675
108MP0008873_increased_physiological_sensi0.74537822
109MP0005025_abnormal_response_to0.74259868
110MP0000537_abnormal_urethra_morphology0.73269485
111MP0001764_abnormal_homeostasis0.72972082
112MP0002210_abnormal_sex_determination0.72819788
113MP0010155_abnormal_intestine_physiology0.72295482
114MP0000477_abnormal_intestine_morphology0.72163347
115MP0000613_abnormal_salivary_gland0.71648124
116MP0008789_abnormal_olfactory_epithelium0.71609888
117MP0001666_abnormal_nutrient_absorption0.71607153
118MP0001145_abnormal_male_reproductive0.71217192
119MP0001800_abnormal_humoral_immune0.70741303
120MP0002102_abnormal_ear_morphology0.70565560
121MP0005174_abnormal_tail_pigmentation0.70299323
122MP0000015_abnormal_ear_pigmentation0.69009668
123MP0003941_abnormal_skin_development0.68854807
124MP0001873_stomach_inflammation0.68677649
125MP0009643_abnormal_urine_homeostasis0.68610989
126MP0002086_abnormal_extraembryonic_tissu0.68492384
127MP0002420_abnormal_adaptive_immunity0.67078572
128MP0003866_abnormal_defecation0.66904789
129MP0002723_abnormal_immune_serum0.66653672
130MP0002095_abnormal_skin_pigmentation0.66049308
131MP0003011_delayed_dark_adaptation0.65319639
132MP0005501_abnormal_skin_physiology0.64584657
133MP0000678_abnormal_parathyroid_gland0.63692220
134MP0001819_abnormal_immune_cell0.62997631
135MP0000858_altered_metastatic_potential0.62932392
136MP0003938_abnormal_ear_development0.61754569
137MP0005332_abnormal_amino_acid0.61199207
138MP0009672_abnormal_birth_weight0.57803489

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of cells of the erythroid lineage (HP:0012130)8.26349627
2Abnormal number of erythroid precursors (HP:0012131)7.75180178
3Reticulocytopenia (HP:0001896)5.94502665
4Macrocytic anemia (HP:0001972)5.02735419
5Pallor (HP:0000980)4.52882911
6Decreased activity of mitochondrial respiratory chain (HP:0008972)4.24859676
7Abnormal activity of mitochondrial respiratory chain (HP:0011922)4.24859676
8Aplastic anemia (HP:0001915)3.70949691
9Hepatocellular necrosis (HP:0001404)3.70034192
10Hepatic necrosis (HP:0002605)3.53993292
11Mitochondrial inheritance (HP:0001427)3.45631427
12Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.45603034
13Acute necrotizing encephalopathy (HP:0006965)3.45098002
14Oral leukoplakia (HP:0002745)3.40095919
15Multiple enchondromatosis (HP:0005701)3.34584654
16Ragged-red muscle fibers (HP:0003200)3.34286279
17Cerebral hypomyelination (HP:0006808)3.30163227
18Abnormal mitochondria in muscle tissue (HP:0008316)3.18806525
19Birth length less than 3rd percentile (HP:0003561)3.12960096
20Increased CSF lactate (HP:0002490)3.12270948
21Increased serum lactate (HP:0002151)3.11633135
22Progressive muscle weakness (HP:0003323)3.11017199
23Muscle abnormality related to mitochondrial dysfunction (HP:0003800)3.10430210
24Acute encephalopathy (HP:0006846)3.03122011
25Microretrognathia (HP:0000308)2.98238805
26Type I transferrin isoform profile (HP:0003642)2.96020916
27Breast hypoplasia (HP:0003187)2.95572390
28Aplasia/Hypoplasia of the sacrum (HP:0008517)2.95047927
29Thrombocytosis (HP:0001894)2.94588446
303-Methylglutaconic aciduria (HP:0003535)2.92105298
31Lipid accumulation in hepatocytes (HP:0006561)2.87320431
32Increased hepatocellular lipid droplets (HP:0006565)2.87031184
33Rough bone trabeculation (HP:0100670)2.84255082
34Microvesicular hepatic steatosis (HP:0001414)2.77570792
35Lactic acidosis (HP:0003128)2.75606292
36Increased intramyocellular lipid droplets (HP:0012240)2.68164600
37Progressive macrocephaly (HP:0004481)2.63227058
38Abnormality of the heme biosynthetic pathway (HP:0010472)2.63186041
39Exertional dyspnea (HP:0002875)2.57510742
40Increased muscle lipid content (HP:0009058)2.53383815
41Cleft eyelid (HP:0000625)2.49049714
42Abnormality of aromatic amino acid family metabolism (HP:0004338)2.47213790
43Colon cancer (HP:0003003)2.47129480
44Reduced antithrombin III activity (HP:0001976)2.46916050
45Trismus (HP:0000211)2.46089117
46Carpal bone hypoplasia (HP:0001498)2.45368854
47Progressive microcephaly (HP:0000253)2.44500700
48Cerebral edema (HP:0002181)2.41812639
49Hyperglycinemia (HP:0002154)2.41554715
50Exercise intolerance (HP:0003546)2.38251488
51Testicular atrophy (HP:0000029)2.35652686
52Abnormal hemoglobin (HP:0011902)2.35400022
53Respiratory failure (HP:0002878)2.34918359
54Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.34547748
55Abnormal protein N-linked glycosylation (HP:0012347)2.34547748
56Abnormal protein glycosylation (HP:0012346)2.34547748
57Abnormal glycosylation (HP:0012345)2.34547748
58Respiratory difficulties (HP:0002880)2.32443651
59Abnormality of reticulocytes (HP:0004312)2.31779514
60Opisthotonus (HP:0002179)2.30747745
61Poor head control (HP:0002421)2.29864551
62Petechiae (HP:0000967)2.27864766
63CNS hypomyelination (HP:0003429)2.26894012
64Abnormal trabecular bone morphology (HP:0100671)2.24014296
65Abnormality of glycolysis (HP:0004366)2.22767729
66Increased serum pyruvate (HP:0003542)2.22767729
67Pancytopenia (HP:0001876)2.21752805
68Generalized aminoaciduria (HP:0002909)2.20707133
69Renal Fanconi syndrome (HP:0001994)2.20182608
70Dicarboxylic aciduria (HP:0003215)2.14781079
71Abnormality of dicarboxylic acid metabolism (HP:0010995)2.14781079
72Increased serum ferritin (HP:0003281)2.13120004
73CNS demyelination (HP:0007305)2.11868754
74Methylmalonic aciduria (HP:0012120)2.09539935
75Sparse eyelashes (HP:0000653)2.06223086
76Absent thumb (HP:0009777)2.05722998
77Optic disc pallor (HP:0000543)2.02940452
78Premature ovarian failure (HP:0008209)2.02314428
79Asplenia (HP:0001746)1.96103080
80Lethargy (HP:0001254)1.96032969
81Abnormality of the anterior horn cell (HP:0006802)1.94498507
82Degeneration of anterior horn cells (HP:0002398)1.94498507
83Secondary amenorrhea (HP:0000869)1.93037854
84Stenosis of the external auditory canal (HP:0000402)1.92368889
85Gliosis (HP:0002171)1.90695397
86Sensory axonal neuropathy (HP:0003390)1.90573483
87Premature graying of hair (HP:0002216)1.89900849
88Postnatal microcephaly (HP:0005484)1.85755671
89Neoplasm of the pancreas (HP:0002894)1.85716295
90IgM deficiency (HP:0002850)1.85695296
91Selective tooth agenesis (HP:0001592)1.85078375
92Abnormality of the preputium (HP:0100587)1.84588499
93Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.83376722
94Abnormality of alanine metabolism (HP:0010916)1.83376722
95Hyperalaninemia (HP:0003348)1.83376722
96Rhabdomyolysis (HP:0003201)1.83311133
9711 pairs of ribs (HP:0000878)1.83264093
98Death in infancy (HP:0001522)1.82992244
99Emotional lability (HP:0000712)1.82273229
100Glycosuria (HP:0003076)1.80095146
101Abnormality of urine glucose concentration (HP:0011016)1.80095146
102Leukodystrophy (HP:0002415)1.77340198
103Horseshoe kidney (HP:0000085)1.74934835
104Hypergonadotropic hypogonadism (HP:0000815)1.73923475
105Congenital, generalized hypertrichosis (HP:0004540)1.73295275
106Depressed nasal ridge (HP:0000457)1.72944362
107Spastic paraparesis (HP:0002313)1.72757237
108Cellular immunodeficiency (HP:0005374)1.72733782
109Chronic otitis media (HP:0000389)1.71885689
110Hyperammonemia (HP:0001987)1.71847664
111Aplasia/Hypoplasia of the spleen (HP:0010451)1.71575375
112Abnormality of iron homeostasis (HP:0011031)1.71305391
113Nausea (HP:0002018)1.70783441
114Abnormality of the umbilical cord (HP:0010881)1.70573098
115Hyperphosphaturia (HP:0003109)1.70207016
116Muscle fiber atrophy (HP:0100295)1.70067893
117Poor suck (HP:0002033)1.69731699
118Cerebral palsy (HP:0100021)1.69584109
119Hypoplasia of the radius (HP:0002984)1.69478689
120Triphalangeal thumb (HP:0001199)1.69259639
121Elevated erythrocyte sedimentation rate (HP:0003565)1.69092536
122Seborrheic dermatitis (HP:0001051)1.68866897
123Poikiloderma (HP:0001029)1.67909496
124Abnormality of serum amino acid levels (HP:0003112)1.66468568
125Bone marrow hypocellularity (HP:0005528)1.66392893
126Abnormality of the axillary hair (HP:0100134)1.65899681
127Dysphonia (HP:0001618)1.65704316
128Vomiting (HP:0002013)1.64076456
129Unsteady gait (HP:0002317)1.63992561
130Hyperglycinuria (HP:0003108)1.63820692
131Neoplasm of the adrenal gland (HP:0100631)1.60438229

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK25.25066967
2NME25.07628355
3BUB14.89070222
4WEE13.93105357
5STK163.54423299
6EIF2AK12.80896777
7ZAK2.51790327
8BCKDK2.50219360
9DYRK32.49514209
10BRSK22.26515282
11EIF2AK32.19384421
12VRK12.10491090
13PASK1.95872102
14KDR1.93979728
15SMG11.92428355
16MAP4K11.88834583
17PIM21.85928275
18RPS6KB21.77832090
19NEK11.71986195
20TESK21.71728091
21CDC71.70799824
22TLK11.68963792
23TESK11.66480035
24MAP3K111.62527002
25CDK71.54907761
26CDK191.52985465
27RPS6KA41.51138888
28ACVR1B1.49837565
29NEK21.49541411
30NME11.49063514
31TAF11.35771729
32FLT31.35386479
33LRRK21.34893272
34SRPK11.34226402
35MST41.32624351
36AURKB1.27964781
37PLK41.27624041
38MAP2K31.23081723
39AURKA1.16801297
40NUAK11.15608012
41MAPKAPK31.14731225
42PLK11.13489691
43DYRK21.12335588
44DAPK11.11731721
45CDK81.10656808
46TGFBR11.10072133
47PDK21.09984757
48MKNK11.09054653
49BRSK11.08627370
50NLK0.98788108
51CDK40.97551182
52SCYL20.95996369
53ABL20.93706187
54MAP2K70.92849125
55ZAP700.92064641
56ARAF0.91250572
57MAP3K80.89679026
58CSNK1G30.88142839
59EEF2K0.85958654
60TEC0.85638580
61RPS6KA50.85479005
62PAK40.84020509
63ILK0.83262681
64MAP3K30.80261889
65TTK0.80046626
66DAPK30.78928982
67ERN10.76478134
68PAK10.76039511
69BTK0.75850713
70CSNK1G10.75202779
71CHEK20.75006443
72MAP2K20.74962753
73GRK60.74869645
74IRAK30.74558883
75MKNK20.73256841
76MAPKAPK50.73071977
77PLK30.72990155
78CSNK1G20.72570895
79STK100.69147203
80CSNK2A20.68339571
81CSNK2A10.66653344
82ATR0.64443527
83MAP4K20.63414323
84MUSK0.63013279
85KIT0.60797047
86BRAF0.58327554
87TYK20.56561351
88PIM10.55509948
89IRAK40.53516145
90TSSK60.51397380
91AKT20.51331130
92RAF10.50574740
93TIE10.47199735
94MAPK150.46900931
95TAOK20.44508454
96EPHA20.43399883
97PRKCI0.42435611
98CHEK10.40916900
99BLK0.39948311
100CCNB10.38672882
101CSNK1A1L0.38164505
102CDK20.37679390
103MOS0.37623287
104LIMK10.36071305
105PIK3CG0.35670656
106STK40.35619880
107MAPK110.35288727
108ATM0.35222371
109PBK0.33887151
110MYLK0.33877586
111IKBKB0.33740843
112CAMKK20.33268412
113MAP3K120.32805535
114GRK10.32553657
115CSF1R0.32376220
116CAMK2G0.29798347
117MAP2K60.29255671
118SYK0.28787444
119PAK20.27803343
120GRK50.27747366
121MAPKAPK20.27632249
122EIF2AK20.26581630
123CSNK1A10.25807097
124CDK140.25345510
125CDK11A0.25173475
126PRKCQ0.24608780
127CDK10.24538387
128BMPR1B0.21563127
129CSNK1E0.21334567
130TRIM280.21073860
131PRKCD0.19417682
132ALK0.19389932

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030106.12770313
2RNA polymerase_Homo sapiens_hsa030203.81592914
3DNA replication_Homo sapiens_hsa030303.75938263
4Proteasome_Homo sapiens_hsa030503.41777102
5Mismatch repair_Homo sapiens_hsa034302.81079106
6Pyrimidine metabolism_Homo sapiens_hsa002402.73398617
7* Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.70871920
8Spliceosome_Homo sapiens_hsa030402.66178053
9Protein export_Homo sapiens_hsa030602.38944480
10Folate biosynthesis_Homo sapiens_hsa007902.35329906
11Sulfur relay system_Homo sapiens_hsa041222.23265087
12Oxidative phosphorylation_Homo sapiens_hsa001902.23120103
13Parkinsons disease_Homo sapiens_hsa050122.22785429
14Homologous recombination_Homo sapiens_hsa034402.20196854
15Base excision repair_Homo sapiens_hsa034102.18709028
16Nucleotide excision repair_Homo sapiens_hsa034202.18584392
17RNA transport_Homo sapiens_hsa030132.03486799
18Basal transcription factors_Homo sapiens_hsa030221.70954006
19Huntingtons disease_Homo sapiens_hsa050161.69088667
20One carbon pool by folate_Homo sapiens_hsa006701.65217508
21Cell cycle_Homo sapiens_hsa041101.56145257
22Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.49007154
23Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.43358386
24Purine metabolism_Homo sapiens_hsa002301.42462195
25RNA degradation_Homo sapiens_hsa030181.40238108
26Alzheimers disease_Homo sapiens_hsa050101.32045804
27Drug metabolism - other enzymes_Homo sapiens_hsa009831.31919140
28Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.29790672
29Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.26055292
30Non-homologous end-joining_Homo sapiens_hsa034501.23467309
31Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.21256546
32Vitamin B6 metabolism_Homo sapiens_hsa007501.19499057
33Fanconi anemia pathway_Homo sapiens_hsa034601.17984805
34Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.11238817
35Cysteine and methionine metabolism_Homo sapiens_hsa002701.11132609
36Cyanoamino acid metabolism_Homo sapiens_hsa004601.10662415
37Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.09620856
38Pentose phosphate pathway_Homo sapiens_hsa000301.07591327
39p53 signaling pathway_Homo sapiens_hsa041151.03001610
40Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.02951568
41Glutathione metabolism_Homo sapiens_hsa004801.01274707
42Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.00808326
43Phenylalanine metabolism_Homo sapiens_hsa003600.98139724
44Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.93127933
45Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.92310521
46Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.91114344
47Biosynthesis of amino acids_Homo sapiens_hsa012300.78470434
48Epstein-Barr virus infection_Homo sapiens_hsa051690.74820453
49N-Glycan biosynthesis_Homo sapiens_hsa005100.74341308
50Systemic lupus erythematosus_Homo sapiens_hsa053220.73958178
51Maturity onset diabetes of the young_Homo sapiens_hsa049500.73640328
52Metabolic pathways_Homo sapiens_hsa011000.73410284
53Selenocompound metabolism_Homo sapiens_hsa004500.63964004
54Arginine and proline metabolism_Homo sapiens_hsa003300.62497507
55Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.62073589
56mRNA surveillance pathway_Homo sapiens_hsa030150.60628996
57Fatty acid elongation_Homo sapiens_hsa000620.60226385
58Carbon metabolism_Homo sapiens_hsa012000.59258504
59Herpes simplex infection_Homo sapiens_hsa051680.58557441
60Sulfur metabolism_Homo sapiens_hsa009200.58462345
61Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.57107780
62Alcoholism_Homo sapiens_hsa050340.54891698
63Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.51939676
64Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.50722495
65Linoleic acid metabolism_Homo sapiens_hsa005910.49922345
66Arachidonic acid metabolism_Homo sapiens_hsa005900.49422138
67Primary immunodeficiency_Homo sapiens_hsa053400.49335793
68Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.47542797
69Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.43255831
70Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.41940779
71Regulation of autophagy_Homo sapiens_hsa041400.39746463
72Antigen processing and presentation_Homo sapiens_hsa046120.39714940
73Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.39005679
74Thyroid cancer_Homo sapiens_hsa052160.38676761
75Fatty acid metabolism_Homo sapiens_hsa012120.38568211
76Pentose and glucuronate interconversions_Homo sapiens_hsa000400.35896447
77Steroid biosynthesis_Homo sapiens_hsa001000.35013330
78Peroxisome_Homo sapiens_hsa041460.34866710
79Viral carcinogenesis_Homo sapiens_hsa052030.34080626
80Propanoate metabolism_Homo sapiens_hsa006400.33666728
81Pyruvate metabolism_Homo sapiens_hsa006200.33386721
82Cardiac muscle contraction_Homo sapiens_hsa042600.32300031
83Chemical carcinogenesis_Homo sapiens_hsa052040.32244727
84Histidine metabolism_Homo sapiens_hsa003400.31180747
85alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.31070863
86Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.30389905
87Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.29274140
88Butanoate metabolism_Homo sapiens_hsa006500.28779136
89Oocyte meiosis_Homo sapiens_hsa041140.28595299
90Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.28141885
91Arginine biosynthesis_Homo sapiens_hsa002200.26398088
92Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.24616149
93Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.22034840
94Tryptophan metabolism_Homo sapiens_hsa003800.21311886
952-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.20847633
96Vibrio cholerae infection_Homo sapiens_hsa051100.20088574
97Primary bile acid biosynthesis_Homo sapiens_hsa001200.20086002
98beta-Alanine metabolism_Homo sapiens_hsa004100.19984645
99Shigellosis_Homo sapiens_hsa051310.19101573
100HTLV-I infection_Homo sapiens_hsa051660.18881668
101Tyrosine metabolism_Homo sapiens_hsa003500.18853901
102Caffeine metabolism_Homo sapiens_hsa002320.18347898
103Galactose metabolism_Homo sapiens_hsa000520.18151916
104Fructose and mannose metabolism_Homo sapiens_hsa000510.17416952
105Bladder cancer_Homo sapiens_hsa052190.17190199
106Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.16893433
107Transcriptional misregulation in cancer_Homo sapiens_hsa052020.15940228
108Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.15345323
109Legionellosis_Homo sapiens_hsa051340.14552476
110Fat digestion and absorption_Homo sapiens_hsa049750.11634292
111Fatty acid degradation_Homo sapiens_hsa000710.11629562
112Other glycan degradation_Homo sapiens_hsa005110.11264583
113Ether lipid metabolism_Homo sapiens_hsa005650.10555279
114SNARE interactions in vesicular transport_Homo sapiens_hsa041300.09861666
115Collecting duct acid secretion_Homo sapiens_hsa049660.09684230
116Vitamin digestion and absorption_Homo sapiens_hsa049770.07818704

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