IMP4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene, along with IMP3 and MPP10, is part of the 60-80S U3 small nucleolar ribonucleoprotein (U3 snoRNP) complex. This complex is necessary for the early cleavage steps of pre-18S ribosomal RNA processing. Several transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of mitochondrial translation (GO:0070129)4.66553812
2nucleobase biosynthetic process (GO:0046112)4.52921662
3DNA deamination (GO:0045006)4.44374722
4DNA strand elongation involved in DNA replication (GO:0006271)4.43336095
5ribosomal small subunit assembly (GO:0000028)4.35677384
6purine nucleobase biosynthetic process (GO:0009113)4.31555830
7maturation of SSU-rRNA (GO:0030490)4.25136322
8DNA strand elongation (GO:0022616)4.23968654
9establishment of integrated proviral latency (GO:0075713)4.22382444
10telomere maintenance via semi-conservative replication (GO:0032201)4.20272284
11formation of translation preinitiation complex (GO:0001731)4.19316833
12DNA replication initiation (GO:0006270)4.12725163
13ribosomal large subunit biogenesis (GO:0042273)4.04222938
14peptidyl-arginine omega-N-methylation (GO:0035247)4.02039312
15mitotic metaphase plate congression (GO:0007080)3.99254058
16DNA replication checkpoint (GO:0000076)3.93632384
17ribosome biogenesis (GO:0042254)3.90678480
18chaperone-mediated protein transport (GO:0072321)3.89265499
19protein targeting to mitochondrion (GO:0006626)3.87173666
20regulation of cellular amino acid metabolic process (GO:0006521)3.85931243
21ribosome assembly (GO:0042255)3.81781147
22telomere maintenance via recombination (GO:0000722)3.81338726
23ribonucleoprotein complex biogenesis (GO:0022613)3.80171273
24protein maturation by protein folding (GO:0022417)3.78305894
25proteasome assembly (GO:0043248)3.72219210
26IMP biosynthetic process (GO:0006188)3.71126782
27establishment of viral latency (GO:0019043)3.68521588
28deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.64917605
29DNA unwinding involved in DNA replication (GO:0006268)3.63435627
30nucleobase-containing small molecule interconversion (GO:0015949)3.63348747
31CENP-A containing nucleosome assembly (GO:0034080)3.59975008
32rRNA modification (GO:0000154)3.59366279
33establishment of protein localization to mitochondrion (GO:0072655)3.56573137
34transcription from mitochondrial promoter (GO:0006390)3.55674191
35viral transcription (GO:0019083)3.55556544
36signal transduction involved in cell cycle checkpoint (GO:0072395)3.54435539
37regulation of translational termination (GO:0006449)3.54043294
38mitotic recombination (GO:0006312)3.53735806
39metaphase plate congression (GO:0051310)3.52684825
40translational termination (GO:0006415)3.52655642
41* rRNA processing (GO:0006364)3.51780439
42folic acid-containing compound biosynthetic process (GO:0009396)3.50675775
43chromatin remodeling at centromere (GO:0031055)3.49243165
44histone arginine methylation (GO:0034969)3.48222981
45telomere maintenance via telomere lengthening (GO:0010833)3.47954627
46maturation of 5.8S rRNA (GO:0000460)3.47206520
47mitotic nuclear envelope disassembly (GO:0007077)3.45961580
48regulation of translational fidelity (GO:0006450)3.45961560
49ribosomal small subunit biogenesis (GO:0042274)3.45935946
50mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.44961357
51tRNA methylation (GO:0030488)3.43249463
52positive regulation of ligase activity (GO:0051351)3.41055620
53protein localization to kinetochore (GO:0034501)3.41011627
54regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.39915773
55* rRNA metabolic process (GO:0016072)3.38814465
56translational initiation (GO:0006413)3.37893295
57protein localization to mitochondrion (GO:0070585)3.36847172
58peptidyl-histidine modification (GO:0018202)3.33669868
59oxidative phosphorylation (GO:0006119)3.33637606
60pseudouridine synthesis (GO:0001522)3.33350980
61mitochondrial RNA metabolic process (GO:0000959)3.30770141
62kinetochore organization (GO:0051383)3.29067397
63negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.28425448
64tRNA aminoacylation for protein translation (GO:0006418)3.27920374
65spliceosomal snRNP assembly (GO:0000387)3.27407676
66proline biosynthetic process (GO:0006561)3.26740937
67translational elongation (GO:0006414)3.26014371
68negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.25459102
69IMP metabolic process (GO:0046040)3.25035018
70DNA replication-independent nucleosome organization (GO:0034724)3.24025945
71DNA replication-independent nucleosome assembly (GO:0006336)3.24025945
72regulation of ubiquitin-protein transferase activity (GO:0051438)3.23518556
73tRNA aminoacylation (GO:0043039)3.22170326
74amino acid activation (GO:0043038)3.22170326
75anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.20993439
76nucleotide-excision repair, DNA gap filling (GO:0006297)3.19643732
77establishment of chromosome localization (GO:0051303)3.19028898
78regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.18993907
79peptidyl-arginine N-methylation (GO:0035246)3.17898340
80peptidyl-arginine methylation (GO:0018216)3.17898340
81transcription elongation from RNA polymerase III promoter (GO:0006385)3.16326912
82termination of RNA polymerase III transcription (GO:0006386)3.16326912
83positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.16079295
84establishment of protein localization to mitochondrial membrane (GO:0090151)3.15673611
85membrane disassembly (GO:0030397)3.15475923
86nuclear envelope disassembly (GO:0051081)3.15475923
87regulation of ligase activity (GO:0051340)3.14026403
88DNA replication-dependent nucleosome organization (GO:0034723)3.13947044
89DNA replication-dependent nucleosome assembly (GO:0006335)3.13947044
90SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.13853076
91antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.12863922
92GDP-mannose metabolic process (GO:0019673)3.12848248
93kinetochore assembly (GO:0051382)3.12503096
94transcription-coupled nucleotide-excision repair (GO:0006283)3.08953692
95rRNA transcription (GO:0009303)3.08895719
96inner mitochondrial membrane organization (GO:0007007)3.08592316
97folic acid metabolic process (GO:0046655)3.07293824
98regulation of spindle organization (GO:0090224)3.05106673
99cotranslational protein targeting to membrane (GO:0006613)3.04605666
100protein targeting to ER (GO:0045047)3.02708570
101nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.02265525
102L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.01885855
1032-deoxyribonucleotide biosynthetic process (GO:0009265)2.98117744
104deoxyribose phosphate biosynthetic process (GO:0046385)2.98117744
105protein localization to chromosome, centromeric region (GO:0071459)2.97179392
106rRNA methylation (GO:0031167)2.96360255
107positive regulation of cell cycle arrest (GO:0071158)2.96136881
108pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.95441347
109negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.95166529
110negative regulation of ligase activity (GO:0051352)2.95166529
111cullin deneddylation (GO:0010388)2.94937362
112mitochondrial respiratory chain complex assembly (GO:0033108)2.93918766
113cell cycle G1/S phase transition (GO:0044843)2.93825073
114G1/S transition of mitotic cell cycle (GO:0000082)2.93825073
115viral mRNA export from host cell nucleus (GO:0046784)2.93334094
116negative regulation of mRNA processing (GO:0050686)2.92778532
117translation (GO:0006412)2.92573466
118deoxyribonucleotide biosynthetic process (GO:0009263)2.91441382
119cellular component biogenesis (GO:0044085)2.90576787
120regulation of translation in response to stress (GO:0043555)2.90031732
121histone exchange (GO:0043486)2.89961758
122purine nucleotide salvage (GO:0032261)2.89201094
123nuclear pore organization (GO:0006999)2.88563388
124deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.87850246
125regulation of cellular amine metabolic process (GO:0033238)2.87845872
126protein localization to endoplasmic reticulum (GO:0070972)2.87004737
127regulation of nuclear cell cycle DNA replication (GO:0033262)2.86944781
128antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.85982321
129metallo-sulfur cluster assembly (GO:0031163)2.85853820
130iron-sulfur cluster assembly (GO:0016226)2.85853820
131establishment of protein localization to endoplasmic reticulum (GO:0072599)2.85337745
132DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.84006646
133termination of RNA polymerase I transcription (GO:0006363)2.83908847
134signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.81133348
135signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.81133348
136signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.81133348
137intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.80598202
138signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.80598202
139regulation of double-strand break repair via homologous recombination (GO:0010569)2.79728892
140transcription elongation from RNA polymerase I promoter (GO:0006362)2.78467573
141attachment of spindle microtubules to kinetochore (GO:0008608)2.78194327
142exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.78182393
143* ncRNA processing (GO:0034470)2.77266683
144signal transduction involved in DNA integrity checkpoint (GO:0072401)2.76732162
145signal transduction involved in DNA damage checkpoint (GO:0072422)2.76732162
1467-methylguanosine mRNA capping (GO:0006370)2.76687445
147cellular protein complex disassembly (GO:0043624)2.76361348
148telomere organization (GO:0032200)2.76138502
149transcription from RNA polymerase I promoter (GO:0006360)2.75952763
150positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.75357593
151telomere maintenance (GO:0000723)2.74678812

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.59662471
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.22421495
3* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.62642368
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.50307727
5E2F4_17652178_ChIP-ChIP_JURKAT_Human3.31086112
6EST1_17652178_ChIP-ChIP_JURKAT_Human3.20449488
7FOXM1_23109430_ChIP-Seq_U2OS_Human3.18741436
8GABP_17652178_ChIP-ChIP_JURKAT_Human3.13666684
9* JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.10084143
10* ETS1_20019798_ChIP-Seq_JURKAT_Human2.92087341
11MYC_19079543_ChIP-ChIP_MESCs_Mouse2.87330564
12FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.87314412
13* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.87009058
14* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.80957429
15CREB1_15753290_ChIP-ChIP_HEK293T_Human2.68015422
16NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.67451930
17ELF1_17652178_ChIP-ChIP_JURKAT_Human2.44974446
18HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.44620537
19* VDR_23849224_ChIP-Seq_CD4+_Human2.37904127
20NELFA_20434984_ChIP-Seq_ESCs_Mouse2.30622257
21CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.26547280
22XRN2_22483619_ChIP-Seq_HELA_Human2.24658165
23TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.13313671
24FOXP3_21729870_ChIP-Seq_TREG_Human2.09442776
25DCP1A_22483619_ChIP-Seq_HELA_Human2.05446880
26* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.04978662
27SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.02556670
28GABP_19822575_ChIP-Seq_HepG2_Human1.93774044
29HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.92801012
30MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.91886589
31E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.89591085
32MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.84833644
33THAP11_20581084_ChIP-Seq_MESCs_Mouse1.79798600
34AR_21909140_ChIP-Seq_LNCAP_Human1.78911362
35E2F1_21310950_ChIP-Seq_MCF-7_Human1.77005023
36* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.76532914
37* TTF2_22483619_ChIP-Seq_HELA_Human1.76214974
38PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.75920932
39SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.75418354
40FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.74301278
41ELK1_19687146_ChIP-ChIP_HELA_Human1.71769261
42TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.70579655
43* NANOG_18555785_ChIP-Seq_MESCs_Mouse1.66482042
44POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.66271935
45NOTCH1_21737748_ChIP-Seq_TLL_Human1.65998183
46* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.65415188
47SRF_21415370_ChIP-Seq_HL-1_Mouse1.63264372
48CIITA_25753668_ChIP-Seq_RAJI_Human1.61513257
49EGR1_19374776_ChIP-ChIP_THP-1_Human1.60394372
50YY1_21170310_ChIP-Seq_MESCs_Mouse1.58654499
51FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.56251963
52* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.54067546
53PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.52366167
54CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.51184395
55MYC_22102868_ChIP-Seq_BL_Human1.48622339
56* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.47740753
57ZNF263_19887448_ChIP-Seq_K562_Human1.45096542
58ZFX_18555785_ChIP-Seq_MESCs_Mouse1.44506266
59* SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.43540292
60CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.42004791
61ERG_20887958_ChIP-Seq_HPC-7_Mouse1.41123855
62KDM5A_27292631_Chip-Seq_BREAST_Human1.41034029
63KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.40429416
64* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.38624242
65* TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.37278985
66MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.33443114
67* ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.28669392
68* SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.27688273
69* PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.25497440
70* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.19002405
71TFEB_21752829_ChIP-Seq_HELA_Human1.18405017
72SPI1_23547873_ChIP-Seq_NB4_Human1.18383792
73IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.16928783
74POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.14750883
75PADI4_21655091_ChIP-ChIP_MCF-7_Human1.14083835
76E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.13137523
77TET1_21451524_ChIP-Seq_MESCs_Mouse1.11611260
78ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.11000288
79KLF4_18555785_ChIP-Seq_MESCs_Mouse1.07990161
80* HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.07870905
81STAT3_1855785_ChIP-Seq_MESCs_Mouse1.07652694
82POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.07194477
83* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.04033455
84SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.03364038
85ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.02113825
86MYC_18940864_ChIP-ChIP_HL60_Human1.01923149
87TP63_19390658_ChIP-ChIP_HaCaT_Human1.01390152
88FOXP1_21924763_ChIP-Seq_HESCs_Human0.99869724
89TBX5_21415370_ChIP-Seq_HL-1_Mouse0.99702268
90BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.99102942
91* DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.98191656
92SRY_22984422_ChIP-ChIP_TESTIS_Rat0.97555391
93ELK1_22589737_ChIP-Seq_MCF10A_Human0.96424253
94DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.96183400
95SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.95770475
96RBPJ_22232070_ChIP-Seq_NCS_Mouse0.95644153
97TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.94146885
98CTCF_18555785_ChIP-Seq_MESCs_Mouse0.94085667
99VDR_21846776_ChIP-Seq_THP-1_Human0.91971727
100CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.90942202
101KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.90735001
102IRF8_21731497_ChIP-ChIP_J774_Mouse0.89381317
103SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.89243522
104ELF1_20517297_ChIP-Seq_JURKAT_Human0.89095854
105HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.88120098
106CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.87362552
107SOX2_18555785_ChIP-Seq_MESCs_Mouse0.85020915
108MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.82832925
109STAT4_19710469_ChIP-ChIP_TH1__Mouse0.82301771
110* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.81701579
111* CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.81679961
112CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.81434930
113IRF8_22096565_ChIP-ChIP_GC-B_Human0.80144924
114* HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.79621599
115CTCF_26484167_Chip-Seq_Bcells_Mouse0.79458297
116PU.1_20513432_ChIP-Seq_Bcells_Mouse0.79361492
117* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.78653026
118CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.78454814
119MYB_26560356_Chip-Seq_TH1_Human0.76973979
120* KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.76938764
121CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.75977348

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.38737203
2MP0010094_abnormal_chromosome_stability4.15796257
3MP0004957_abnormal_blastocyst_morpholog4.07543955
4MP0003111_abnormal_nucleus_morphology4.05464319
5MP0008057_abnormal_DNA_replication3.75110066
6MP0003077_abnormal_cell_cycle3.70335935
7MP0008058_abnormal_DNA_repair3.36060501
8MP0006035_abnormal_mitochondrial_morpho3.06646863
9MP0005451_abnormal_body_composition3.01801138
10MP0002396_abnormal_hematopoietic_system2.94196125
11MP0008007_abnormal_cellular_replicative2.92834470
12MP0006036_abnormal_mitochondrial_physio2.85496740
13MP0008932_abnormal_embryonic_tissue2.36116104
14MP0004233_abnormal_muscle_weight1.96186621
15MP0001730_embryonic_growth_arrest1.94410392
16MP0000490_abnormal_crypts_of1.93509661
17MP0003763_abnormal_thymus_physiology1.90282568
18MP0000350_abnormal_cell_proliferation1.86217900
19MP0003718_maternal_effect1.85862162
20MP0003786_premature_aging1.85081083
21MP0009333_abnormal_splenocyte_physiolog1.84140614
22MP0003123_paternal_imprinting1.76427535
23MP0003806_abnormal_nucleotide_metabolis1.74877735
24MP0002132_abnormal_respiratory_system1.74630988
25MP0005501_abnormal_skin_physiology1.61693490
26MP0010307_abnormal_tumor_latency1.60701212
27MP0001835_abnormal_antigen_presentation1.58828270
28MP0010352_gastrointestinal_tract_polyps1.58665680
29MP0002796_impaired_skin_barrier1.57449053
30MP0002398_abnormal_bone_marrow1.54567947
31MP0004808_abnormal_hematopoietic_stem1.51842296
32MP0008877_abnormal_DNA_methylation1.50484727
33MP0005670_abnormal_white_adipose1.49783164
34MP0002019_abnormal_tumor_incidence1.47961918
35MP0005671_abnormal_response_to1.46817705
36MP0000313_abnormal_cell_death1.43996493
37MP0001873_stomach_inflammation1.43497355
38MP0005380_embryogenesis_phenotype1.42960780
39MP0001672_abnormal_embryogenesis/_devel1.42960780
40MP0000689_abnormal_spleen_morphology1.42199203
41MP0005397_hematopoietic_system_phenotyp1.41633982
42MP0001545_abnormal_hematopoietic_system1.41633982
43MP0002722_abnormal_immune_system1.41026074
44MP0001697_abnormal_embryo_size1.37955691
45MP0001661_extended_life_span1.37440618
46MP0001727_abnormal_embryo_implantation1.36659350
47MP0002080_prenatal_lethality1.35144485
48MP0003186_abnormal_redox_activity1.32833314
49MP0003984_embryonic_growth_retardation1.32339858
50MP0000703_abnormal_thymus_morphology1.31969529
51MP0004185_abnormal_adipocyte_glucose1.29302871
52MP0002088_abnormal_embryonic_growth/wei1.28462694
53MP0001800_abnormal_humoral_immune1.28288639
54MP0005075_abnormal_melanosome_morpholog1.25069864
55MP0001881_abnormal_mammary_gland1.24915109
56MP0002429_abnormal_blood_cell1.24642994
57MP0008995_early_reproductive_senescence1.23983082
58MP0000716_abnormal_immune_system1.19808060
59MP0001853_heart_inflammation1.18445530
60MP0002452_abnormal_antigen_presenting1.16841081
61MP0009785_altered_susceptibility_to1.16744922
62MP0002420_abnormal_adaptive_immunity1.16489988
63MP0001819_abnormal_immune_cell1.14819227
64MP0006292_abnormal_olfactory_placode1.13126061
65MP0003436_decreased_susceptibility_to1.12362495
66MP0002723_abnormal_immune_serum1.10809297
67MP0002086_abnormal_extraembryonic_tissu1.10132371
68MP0002163_abnormal_gland_morphology1.09866911
69MP0000858_altered_metastatic_potential1.09788070
70MP0001293_anophthalmia1.09067027
71MP0000465_gastrointestinal_hemorrhage1.08508880
72MP0002085_abnormal_embryonic_tissue1.07372198
73MP0003941_abnormal_skin_development1.06631102
74MP0010234_abnormal_vibrissa_follicle1.06393930
75MP0000685_abnormal_immune_system1.04229494
76MP0005000_abnormal_immune_tolerance1.03549939
77MP0003567_abnormal_fetal_cardiomyocyte1.02976563
78MP0004197_abnormal_fetal_growth/weight/1.00151080
79MP0000678_abnormal_parathyroid_gland1.00000123
80MP0005025_abnormal_response_to0.99744780
81MP0002405_respiratory_system_inflammati0.98515900
82MP0002970_abnormal_white_adipose0.97957976
83MP0002210_abnormal_sex_determination0.94520664
84MP0005058_abnormal_lysosome_morphology0.92396967
85MP0005330_cardiomyopathy0.89638763
86MP0002877_abnormal_melanocyte_morpholog0.87889338
87MP0001119_abnormal_female_reproductive0.87679024
88MP0002084_abnormal_developmental_patter0.87394445
89MP0002095_abnormal_skin_pigmentation0.84289175
90MP0001145_abnormal_male_reproductive0.83407309
91MP0010155_abnormal_intestine_physiology0.83186523
92MP0009278_abnormal_bone_marrow0.81911573
93MP0002148_abnormal_hypersensitivity_rea0.81496378
94MP0008260_abnormal_autophagy0.79231829
95MP0002006_tumorigenesis0.78533650
96MP0005266_abnormal_metabolism0.77551997
97MP0009379_abnormal_foot_pigmentation0.77526605
98MP0000015_abnormal_ear_pigmentation0.76907448
99MP0002419_abnormal_innate_immunity0.76554465
100MP0002160_abnormal_reproductive_system0.76370815
101MP0005645_abnormal_hypothalamus_physiol0.76344232
102MP0002269_muscular_atrophy0.75125908
103MP0000358_abnormal_cell_content/0.73941189
104MP0000653_abnormal_sex_gland0.73657674
105MP0002822_catalepsy0.71480066
106MP0001790_abnormal_immune_system0.71307978
107MP0005387_immune_system_phenotype0.71307978
108MP0001764_abnormal_homeostasis0.71294919
109MP0005666_abnormal_adipose_tissue0.70997678
110MP0009840_abnormal_foam_cell0.70959444
111MP0000627_abnormal_mammary_gland0.70570356
112MP0003221_abnormal_cardiomyocyte_apopto0.69995790
113MP0005174_abnormal_tail_pigmentation0.69446381
114MP0009697_abnormal_copulation0.69022384
115MP0005464_abnormal_platelet_physiology0.69017213
116MP0005389_reproductive_system_phenotype0.68994371
117MP0001929_abnormal_gametogenesis0.68137933
118MP0003448_altered_tumor_morphology0.67599266
119MP0000747_muscle_weakness0.67331509
120MP0005384_cellular_phenotype0.67162325
121MP0001845_abnormal_inflammatory_respons0.66548657
122MP0006054_spinal_hemorrhage0.66357775
123MP0005408_hypopigmentation0.65875851
124MP0000372_irregular_coat_pigmentation0.63951693
125MP0005621_abnormal_cell_physiology0.63731646
126MP0003315_abnormal_perineum_morphology0.63653262
127MP0002166_altered_tumor_susceptibility0.63334533
128MP0000477_abnormal_intestine_morphology0.62546078
129MP0002254_reproductive_system_inflammat0.62526678
130MP0003191_abnormal_cellular_cholesterol0.62415787
131MP0003121_genomic_imprinting0.62174000
132MP0001216_abnormal_epidermal_layer0.61831374
133MP0009672_abnormal_birth_weight0.61602367
134MP0000467_abnormal_esophagus_morphology0.60606164
135MP0000749_muscle_degeneration0.60424805
136MP0008873_increased_physiological_sensi0.58533825
137MP0000613_abnormal_salivary_gland0.56504426
138MP0005332_abnormal_amino_acid0.55778170
139MP0002060_abnormal_skin_morphology0.54164394
140MP0001529_abnormal_vocalization0.53332841
141MP0005310_abnormal_salivary_gland0.53077577
142MP0010771_integument_phenotype0.52565423
143MP0005452_abnormal_adipose_tissue0.51518681
144MP0005319_abnormal_enzyme/_coenzyme0.50081691
145MP0000003_abnormal_adipose_tissue0.50050806

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)5.00245500
2Abnormal mitochondria in muscle tissue (HP:0008316)4.55162614
3Reticulocytopenia (HP:0001896)4.48004792
4Acute necrotizing encephalopathy (HP:0006965)4.41721876
5Abnormality of glycolysis (HP:0004366)4.21011637
6Acute encephalopathy (HP:0006846)4.10564732
7Increased serum pyruvate (HP:0003542)3.98786850
8Hepatocellular necrosis (HP:0001404)3.96766497
9Mitochondrial inheritance (HP:0001427)3.94761359
10Abnormal number of erythroid precursors (HP:0012131)3.86500590
11Breast hypoplasia (HP:0003187)3.84203971
12Increased CSF lactate (HP:0002490)3.83212082
13Abnormality of cells of the erythroid lineage (HP:0012130)3.82375763
14Aplastic anemia (HP:0001915)3.79264766
15Chromsome breakage (HP:0040012)3.76496938
16Oral leukoplakia (HP:0002745)3.69370103
17Hepatic necrosis (HP:0002605)3.68837385
18Progressive muscle weakness (HP:0003323)3.65475327
19Ragged-red muscle fibers (HP:0003200)3.57799014
20Chromosomal breakage induced by crosslinking agents (HP:0003221)3.54722259
21Increased intramyocellular lipid droplets (HP:0012240)3.48862154
22Cerebral hypomyelination (HP:0006808)3.44938649
23Rough bone trabeculation (HP:0100670)3.44905177
24Progressive macrocephaly (HP:0004481)3.44414044
25Cerebral edema (HP:0002181)3.42545214
26Lactic acidosis (HP:0003128)3.25285681
27Carpal bone hypoplasia (HP:0001498)3.11459035
28Exercise intolerance (HP:0003546)3.09957597
29Colon cancer (HP:0003003)3.05773573
30Increased muscle lipid content (HP:0009058)3.05106226
31Testicular atrophy (HP:0000029)3.04181588
32Abnormality of the anterior horn cell (HP:0006802)3.03999443
33Degeneration of anterior horn cells (HP:0002398)3.03999443
34Patellar aplasia (HP:0006443)2.99324027
35Abnormality of the preputium (HP:0100587)2.94287519
36Abnormal gallbladder physiology (HP:0012438)2.89164827
37Cholecystitis (HP:0001082)2.89164827
38Premature graying of hair (HP:0002216)2.85125778
39Macrocytic anemia (HP:0001972)2.83214365
40Abnormality of chromosome stability (HP:0003220)2.82301852
41Pallor (HP:0000980)2.81991527
42Aplasia/Hypoplasia of the patella (HP:0006498)2.80732015
43Meckel diverticulum (HP:0002245)2.75850959
44Abnormal trabecular bone morphology (HP:0100671)2.73463017
45Bone marrow hypocellularity (HP:0005528)2.71775773
46Lipid accumulation in hepatocytes (HP:0006561)2.66601184
47Myelodysplasia (HP:0002863)2.66112311
48IgM deficiency (HP:0002850)2.65852067
49Absent thumb (HP:0009777)2.65615242
50Thrombocytosis (HP:0001894)2.64904003
51Abnormality of the ileum (HP:0001549)2.62826426
52Selective tooth agenesis (HP:0001592)2.60259064
53Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.58549857
54Abnormal protein N-linked glycosylation (HP:0012347)2.58549857
55Abnormal protein glycosylation (HP:0012346)2.58549857
56Abnormal glycosylation (HP:0012345)2.58549857
57Type I transferrin isoform profile (HP:0003642)2.56731123
58Premature ovarian failure (HP:0008209)2.49026205
59Microretrognathia (HP:0000308)2.46448352
60Respiratory failure (HP:0002878)2.46415900
61Multiple enchondromatosis (HP:0005701)2.46193599
62Secondary amenorrhea (HP:0000869)2.45881463
63Agnosia (HP:0010524)2.41433713
64Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.40846054
65Pancytopenia (HP:0001876)2.40214179
66Aplasia/Hypoplasia of the uvula (HP:0010293)2.38776184
67Trismus (HP:0000211)2.37682393
68Cellular immunodeficiency (HP:0005374)2.36920094
69Lymphoma (HP:0002665)2.36403300
70Medulloblastoma (HP:0002885)2.34685390
71Respiratory difficulties (HP:0002880)2.33640282
7211 pairs of ribs (HP:0000878)2.30403901
73Leukodystrophy (HP:0002415)2.28811293
74Absent radius (HP:0003974)2.28372754
75Duplicated collecting system (HP:0000081)2.28338773
76Progressive external ophthalmoplegia (HP:0000590)2.28193768
77Abnormality of pyrimidine metabolism (HP:0004353)2.27367734
78Opisthotonus (HP:0002179)2.27171294
79Impulsivity (HP:0100710)2.25816755
80Emotional lability (HP:0000712)2.24261623
81Petechiae (HP:0000967)2.22044230
82Small intestinal stenosis (HP:0012848)2.20579538
83Duodenal stenosis (HP:0100867)2.20579538
84Cleft eyelid (HP:0000625)2.20078335
85Aplasia/Hypoplasia of the sacrum (HP:0008517)2.18838613
86Renal Fanconi syndrome (HP:0001994)2.16443650
87Muscle fiber atrophy (HP:0100295)2.15702514
88IgG deficiency (HP:0004315)2.15263353
89Combined immunodeficiency (HP:0005387)2.15055475
90Horseshoe kidney (HP:0000085)2.14775240
91Spastic paraparesis (HP:0002313)2.14533525
92Neoplasm of the pancreas (HP:0002894)2.13577735
93Irregular epiphyses (HP:0010582)2.09130971
94Type 2 muscle fiber atrophy (HP:0003554)2.08072051
95Aplasia involving forearm bones (HP:0009822)2.07364060
96Absent forearm bone (HP:0003953)2.07364060
97Abnormality of dicarboxylic acid metabolism (HP:0010995)2.07179834
98Dicarboxylic aciduria (HP:0003215)2.07179834
99Increased serum lactate (HP:0002151)2.06042214
100Lethargy (HP:0001254)2.05596237
101Progressive microcephaly (HP:0000253)2.04994105
102Reduced antithrombin III activity (HP:0001976)2.04212336
103Hypokinesia (HP:0002375)2.03327931
104Sloping forehead (HP:0000340)2.03084910
105Ectopic kidney (HP:0000086)2.02553797
106Triphalangeal thumb (HP:0001199)2.02049267
107Abnormality of T cells (HP:0002843)2.01170384
108Severe combined immunodeficiency (HP:0004430)2.00222905
109Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.99936906
110Tracheoesophageal fistula (HP:0002575)1.99183572
111Abnormality of T cell physiology (HP:0011840)1.99086962
112Abnormal lung lobation (HP:0002101)1.96704260
113CNS hypomyelination (HP:0003429)1.96337331
114Gout (HP:0001997)1.95554282
115Pulmonary fibrosis (HP:0002206)1.95053520
116Rhabdomyosarcoma (HP:0002859)1.94535042
117Microvesicular hepatic steatosis (HP:0001414)1.91251902
118Methylmalonic aciduria (HP:0012120)1.90601606
119Amaurosis fugax (HP:0100576)1.89171708
120Death in infancy (HP:0001522)1.88436030
121Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.88106028
122Abnormality of the renal collecting system (HP:0004742)1.88072954
123Abnormality of DNA repair (HP:0003254)1.87614591
124Abnormality of methionine metabolism (HP:0010901)1.86073411
125Decreased activity of mitochondrial respiratory chain (HP:0008972)1.85870877
126Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.85870877
127Abnormality of alanine metabolism (HP:0010916)1.85772111
128Hyperalaninemia (HP:0003348)1.85772111
129Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.85772111
130Exertional dyspnea (HP:0002875)1.85404250
131Sparse eyelashes (HP:0000653)1.85373268
1323-Methylglutaconic aciduria (HP:0003535)1.85034208
133CNS demyelination (HP:0007305)1.84317161
134Poor head control (HP:0002421)1.83207079
135T lymphocytopenia (HP:0005403)1.83170749
136Rhabdomyolysis (HP:0003201)1.83125599
137Unilateral renal agenesis (HP:0000122)1.82853985
138Glossoptosis (HP:0000162)1.81991857
139Granulocytopenia (HP:0001913)1.79579017
140Abnormality of the heme biosynthetic pathway (HP:0010472)1.79577247
141Reduced subcutaneous adipose tissue (HP:0003758)1.79361578
142Abnormality of the duodenum (HP:0002246)1.78571724
143Ureteral duplication (HP:0000073)1.78564462
144Abnormality of placental membranes (HP:0011409)1.78296956
145Amniotic constriction ring (HP:0009775)1.78296956
146Megaloblastic anemia (HP:0001889)1.77193155
147Fasciculations (HP:0002380)1.75472840
148Squamous cell carcinoma (HP:0002860)1.74278521
149Increased hepatocellular lipid droplets (HP:0006565)1.74231109
150Short thumb (HP:0009778)1.73995568
151Leukopenia (HP:0001882)1.73308130
152Hypoplasia of the radius (HP:0002984)1.73223158
153Abnormality of T cell number (HP:0011839)1.73017221
154Hypergonadotropic hypogonadism (HP:0000815)1.72833778
155Abnormality of reticulocytes (HP:0004312)1.71360341
156Upper limb muscle weakness (HP:0003484)1.70827842
157Seborrheic dermatitis (HP:0001051)1.69075244
158Athetosis (HP:0002305)1.68391427
159Acute hepatic failure (HP:0006554)1.68271806
160Cholelithiasis (HP:0001081)1.66170465

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB14.59146177
2VRK24.09933582
3EIF2AK13.91658966
4WEE13.64284394
5CDC72.98426123
6SRPK12.76699335
7STK162.68865868
8NME22.68789124
9TSSK62.60894108
10EIF2AK32.46783112
11NEK22.27190708
12BRSK22.09991187
13SMG12.09956975
14PLK42.08555137
15VRK11.99256236
16TTK1.92326357
17TLK11.85798926
18MKNK11.79599430
19MAP4K11.73976952
20PLK11.73880756
21TESK21.57246422
22ZAK1.52968824
23ACVR1B1.51627753
24PIM21.50294779
25CCNB11.49954830
26ATR1.49859412
27CDK71.49743189
28AURKB1.48405933
29PLK31.43690429
30STK101.42905118
31MKNK21.42430078
32KDR1.40415294
33RPS6KA41.39687269
34DYRK31.35837114
35ARAF1.33794683
36TXK1.28321111
37NEK11.27813900
38IRAK31.27718151
39ERN11.21543105
40PRPF4B1.21275653
41PASK1.19835479
42DAPK11.18909845
43CDK41.14083770
44PIM11.13680808
45EPHA21.12349041
46TRIB31.11908724
47BRSK11.10736805
48LIMK11.10273594
49CHEK21.09097717
50RPS6KB21.08383040
51EIF2AK21.08165826
52PDK21.06694699
53MAP3K81.05465033
54AURKA1.05407128
55ZAP701.00826035
56CHEK10.97335850
57TEC0.96588247
58STK40.94996974
59MAP3K110.90409800
60IRAK40.89139385
61MST1R0.89005632
62MAPKAPK30.87795292
63TGFBR10.86175404
64BTK0.85763919
65MAP4K20.84321396
66PAK40.84246634
67CSNK1G30.81941969
68NEK90.79232322
69IKBKB0.74844169
70ATM0.72847966
71MAPK110.71547140
72CSNK2A10.70899740
73BCKDK0.70822995
74CSNK2A20.68332240
75NUAK10.68018928
76JAK30.67980159
77SCYL20.67867736
78BLK0.67806578
79ILK0.67416969
80MAP2K30.67086011
81CLK10.67078945
82NLK0.66349605
83TRIM280.66250230
84FLT30.66032981
85PBK0.65801549
86CDK20.64593760
87CDK120.64453159
88CDK80.63818946
89AKT20.62971746
90ABL20.61663263
91CSNK1A1L0.60399097
92CDK190.60169937
93PAK10.60156322
94MAPKAPK50.59017274
95PRKD30.58438524
96RPS6KA50.57691177
97MST40.55754672
98STK30.55693812
99TYK20.48928446
100NME10.48923381
101CHUK0.48366382
102TAOK20.46862634
103TESK10.46333143
104KIT0.45686189
105CDK90.45474511
106MAP3K100.45374218
107CDK10.45344023
108LYN0.45032350
109STK38L0.44856398
110MARK30.44708019
111BRD40.44666889
112RAF10.43784576
113LRRK20.43782802
114DAPK30.43720291
115ALK0.43658108
116MAP3K140.43429544
117PRKCI0.41320010
118EEF2K0.41201655
119TAF10.40641207
120ICK0.37998395
121MAP3K30.37168197
122CSF1R0.36954992
123DYRK20.35928959
124MELK0.35743482
125STK240.35419903
126BRAF0.35320213
127LCK0.34758445
128TBK10.34393702
129CSNK1G10.33678327
130CAMK2G0.30130310
131MAP3K120.28955587
132CSNK1G20.27404842
133CDK11A0.27106820
134SIK30.26696799
135INSRR0.26256073
136CDK140.26110086

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.45202404
2Mismatch repair_Homo sapiens_hsa034303.72807732
3* Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.67116846
4Proteasome_Homo sapiens_hsa030503.55506531
5Ribosome_Homo sapiens_hsa030103.53727255
6RNA polymerase_Homo sapiens_hsa030203.51985128
7Spliceosome_Homo sapiens_hsa030403.01960255
8RNA transport_Homo sapiens_hsa030132.85170482
9Base excision repair_Homo sapiens_hsa034102.85004058
10Homologous recombination_Homo sapiens_hsa034402.82341078
11Pyrimidine metabolism_Homo sapiens_hsa002402.57488328
12Nucleotide excision repair_Homo sapiens_hsa034202.54420429
13One carbon pool by folate_Homo sapiens_hsa006702.51953429
14Cell cycle_Homo sapiens_hsa041102.27699105
15Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.20718477
16Oxidative phosphorylation_Homo sapiens_hsa001902.07581027
17Fanconi anemia pathway_Homo sapiens_hsa034601.96528551
18Basal transcription factors_Homo sapiens_hsa030221.94666297
19Non-homologous end-joining_Homo sapiens_hsa034501.93045631
20RNA degradation_Homo sapiens_hsa030181.85151309
21Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.82038788
22Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.52372923
23p53 signaling pathway_Homo sapiens_hsa041151.48206552
24Vitamin B6 metabolism_Homo sapiens_hsa007501.42239684
25Purine metabolism_Homo sapiens_hsa002301.36347947
26Folate biosynthesis_Homo sapiens_hsa007901.27938925
27mRNA surveillance pathway_Homo sapiens_hsa030151.27318663
28Pyruvate metabolism_Homo sapiens_hsa006201.26940767
29Epstein-Barr virus infection_Homo sapiens_hsa051691.23850580
30Protein export_Homo sapiens_hsa030601.23069241
31Antigen processing and presentation_Homo sapiens_hsa046121.21944510
32Alzheimers disease_Homo sapiens_hsa050101.15427615
33Primary immunodeficiency_Homo sapiens_hsa053401.10810292
34Herpes simplex infection_Homo sapiens_hsa051681.09427374
35Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.07294029
36Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.01921011
37Sulfur metabolism_Homo sapiens_hsa009200.99722597
38Sulfur relay system_Homo sapiens_hsa041220.97396224
39Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.97194566
40Fatty acid elongation_Homo sapiens_hsa000620.97011217
41Pentose phosphate pathway_Homo sapiens_hsa000300.94590162
42Cysteine and methionine metabolism_Homo sapiens_hsa002700.92432922
43Legionellosis_Homo sapiens_hsa051340.92010891
44Drug metabolism - other enzymes_Homo sapiens_hsa009830.86851453
45Systemic lupus erythematosus_Homo sapiens_hsa053220.81974069
46NF-kappa B signaling pathway_Homo sapiens_hsa040640.79552075
47Viral carcinogenesis_Homo sapiens_hsa052030.76668451
48Measles_Homo sapiens_hsa051620.76474764
49Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.75756949
50Selenocompound metabolism_Homo sapiens_hsa004500.74882238
51Biosynthesis of amino acids_Homo sapiens_hsa012300.73631959
52Cyanoamino acid metabolism_Homo sapiens_hsa004600.71743501
53Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.69903724
54Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.66233819
55Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.64415059
56HTLV-I infection_Homo sapiens_hsa051660.62317793
57Intestinal immune network for IgA production_Homo sapiens_hsa046720.61913910
58Allograft rejection_Homo sapiens_hsa053300.61689319
59Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.60379447
60Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.59900410
61RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.59810413
62Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.59285639
63Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.58744334
64Graft-versus-host disease_Homo sapiens_hsa053320.58728583
65Hematopoietic cell lineage_Homo sapiens_hsa046400.56589695
66Propanoate metabolism_Homo sapiens_hsa006400.54603289
67Vibrio cholerae infection_Homo sapiens_hsa051100.52407907
68Apoptosis_Homo sapiens_hsa042100.52346343
69Thyroid cancer_Homo sapiens_hsa052160.51462995
70Glutathione metabolism_Homo sapiens_hsa004800.50884782
71NOD-like receptor signaling pathway_Homo sapiens_hsa046210.47995327
72Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.47993215
73Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.46513660
74Steroid biosynthesis_Homo sapiens_hsa001000.46418694
75Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.44947119
76Regulation of autophagy_Homo sapiens_hsa041400.44391209
77Leishmaniasis_Homo sapiens_hsa051400.43403956
78Huntingtons disease_Homo sapiens_hsa050160.42665293
79Shigellosis_Homo sapiens_hsa051310.41862430
80SNARE interactions in vesicular transport_Homo sapiens_hsa041300.40952333
81Carbon metabolism_Homo sapiens_hsa012000.40403474
82Small cell lung cancer_Homo sapiens_hsa052220.40114085
83Asthma_Homo sapiens_hsa053100.39833541
84Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.39564835
85Influenza A_Homo sapiens_hsa051640.39544031
86Transcriptional misregulation in cancer_Homo sapiens_hsa052020.38674719
87N-Glycan biosynthesis_Homo sapiens_hsa005100.38244233
88Hepatitis B_Homo sapiens_hsa051610.37614182
89Other glycan degradation_Homo sapiens_hsa005110.37562786
90Oocyte meiosis_Homo sapiens_hsa041140.37490150
91Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.35205177
92Phenylalanine metabolism_Homo sapiens_hsa003600.34951474
93Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.34450416
94Peroxisome_Homo sapiens_hsa041460.32325251
95Arginine biosynthesis_Homo sapiens_hsa002200.31170372
96Metabolic pathways_Homo sapiens_hsa011000.30865631
97Autoimmune thyroid disease_Homo sapiens_hsa053200.30787156
98Central carbon metabolism in cancer_Homo sapiens_hsa052300.30689325
99Arachidonic acid metabolism_Homo sapiens_hsa005900.30604156
100Cardiac muscle contraction_Homo sapiens_hsa042600.29232450
101MicroRNAs in cancer_Homo sapiens_hsa052060.27869873
102Jak-STAT signaling pathway_Homo sapiens_hsa046300.26289601
103Parkinsons disease_Homo sapiens_hsa050120.26236443
104Fructose and mannose metabolism_Homo sapiens_hsa000510.24976684
105Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.24935722
1062-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.24874935
107Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.21812431
108Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.21635982
109Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.21197872
110Galactose metabolism_Homo sapiens_hsa000520.20485266
111Fatty acid metabolism_Homo sapiens_hsa012120.19797747
112Acute myeloid leukemia_Homo sapiens_hsa052210.19166529
113Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.19009751
114Vitamin digestion and absorption_Homo sapiens_hsa049770.18767076
115Tyrosine metabolism_Homo sapiens_hsa003500.18714110
116Type I diabetes mellitus_Homo sapiens_hsa049400.18081926
117T cell receptor signaling pathway_Homo sapiens_hsa046600.16122111
118Arginine and proline metabolism_Homo sapiens_hsa003300.14220256
119Viral myocarditis_Homo sapiens_hsa054160.14208095
120Pentose and glucuronate interconversions_Homo sapiens_hsa000400.13921594
121Bladder cancer_Homo sapiens_hsa052190.13881614
122Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.13827554
123TGF-beta signaling pathway_Homo sapiens_hsa043500.12905489
124HIF-1 signaling pathway_Homo sapiens_hsa040660.12218169
125Toll-like receptor signaling pathway_Homo sapiens_hsa046200.12138483
126Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.08124903
127Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.04671507
128Butanoate metabolism_Homo sapiens_hsa006500.03208047
129beta-Alanine metabolism_Homo sapiens_hsa004100.02932721

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