IMPA1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes an enzyme that dephosphorylates myo-inositol monophosphate to generate free myo-inositol, a precursor of phosphatidylinositol, and is therefore an important modulator of intracellular signal transduction via the production of the second messengers myoinositol 1,4,5-trisphosphate and diacylglycerol. This enzyme can also use myo-inositol-1,3-diphosphate, myo-inositol-1,4-diphosphate, scyllo-inositol-phosphate, glucose-1-phosphate, glucose-6-phosphate, fructose-1-phosphate, beta-glycerophosphate, and 2'-AMP as substrates. This enzyme shows magnesium-dependent phosphatase activity and is inhibited by therapeutic concentrations of lithium. Inhibition of inositol monophosphate hydroylosis and subsequent depletion of inositol for phosphatidylinositol synthesis may explain the anti-manic and anti-depressive effects of lithium administered to treat bipolar disorder. Alternative splicing results in multiple transcript variants encoding distinct isoforms. A pseudogene of this gene is also present on chromosome 8q21.13. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cullin deneddylation (GO:0010388)5.75990494
2L-phenylalanine catabolic process (GO:0006559)5.59241189
3erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)5.59241189
4L-phenylalanine metabolic process (GO:0006558)5.42070701
5erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)5.42070701
6protein deneddylation (GO:0000338)5.28113927
7aromatic amino acid family catabolic process (GO:0009074)5.02857762
8aldehyde catabolic process (GO:0046185)4.69481825
9glyoxylate metabolic process (GO:0046487)4.67179641
10tryptophan catabolic process (GO:0006569)4.48236452
11indole-containing compound catabolic process (GO:0042436)4.48236452
12indolalkylamine catabolic process (GO:0046218)4.48236452
13tryptophan metabolic process (GO:0006568)4.30753249
14synapsis (GO:0007129)4.25973610
15kynurenine metabolic process (GO:0070189)4.21454216
16platelet dense granule organization (GO:0060155)4.10482628
17bile acid biosynthetic process (GO:0006699)4.04754954
18oxaloacetate metabolic process (GO:0006107)4.03398152
19DNA double-strand break processing (GO:0000729)3.97373929
20triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.94883920
21alpha-linolenic acid metabolic process (GO:0036109)3.81492937
22high-density lipoprotein particle remodeling (GO:0034375)3.80549896
23cysteine metabolic process (GO:0006534)3.79200404
24lysine metabolic process (GO:0006553)3.78945681
25lysine catabolic process (GO:0006554)3.78945681
26urea metabolic process (GO:0019627)3.78911155
27urea cycle (GO:0000050)3.78911155
28sulfur amino acid catabolic process (GO:0000098)3.75096958
29amino-acid betaine metabolic process (GO:0006577)3.74766967
30CENP-A containing nucleosome assembly (GO:0034080)3.74477105
31chromatin remodeling at centromere (GO:0031055)3.64927595
32killing of cells in other organism involved in symbiotic interaction (GO:0051883)3.59596469
33disruption of cells of other organism involved in symbiotic interaction (GO:0051818)3.59596469
34aromatic amino acid family metabolic process (GO:0009072)3.58520994
35fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.54254272
36cellular glucuronidation (GO:0052695)3.53448980
37folic acid-containing compound biosynthetic process (GO:0009396)3.49170711
38regulation of cholesterol esterification (GO:0010872)3.48175088
39cellular biogenic amine catabolic process (GO:0042402)3.47183481
40amine catabolic process (GO:0009310)3.47183481
41signal peptide processing (GO:0006465)3.46784230
42succinate metabolic process (GO:0006105)3.45649450
43nitrogen cycle metabolic process (GO:0071941)3.44478029
44regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.43822258
45regulation of mitotic spindle checkpoint (GO:1903504)3.43822258
46bile acid metabolic process (GO:0008206)3.42246336
47regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)3.39382774
48proteasome assembly (GO:0043248)3.38578515
49serine family amino acid biosynthetic process (GO:0009070)3.34972067
50carnitine metabolic process (GO:0009437)3.33309454
51benzene-containing compound metabolic process (GO:0042537)3.33177155
52uronic acid metabolic process (GO:0006063)3.31339816
53glucuronate metabolic process (GO:0019585)3.31339816
54reverse cholesterol transport (GO:0043691)3.30901043
55negative regulation of fibrinolysis (GO:0051918)3.30047770
56tyrosine metabolic process (GO:0006570)3.29717854
57protein-lipid complex remodeling (GO:0034368)3.27775295
58macromolecular complex remodeling (GO:0034367)3.27775295
59plasma lipoprotein particle remodeling (GO:0034369)3.27775295
60imidazole-containing compound metabolic process (GO:0052803)3.27627559
61glutamate metabolic process (GO:0006536)3.27571555
62UMP metabolic process (GO:0046049)3.24661028
63pyrimidine ribonucleoside monophosphate metabolic process (GO:0009173)3.24661028
64UMP biosynthetic process (GO:0006222)3.24661028
65pyrimidine ribonucleoside monophosphate biosynthetic process (GO:0009174)3.24661028
66alpha-amino acid catabolic process (GO:1901606)3.22970795
67non-recombinational repair (GO:0000726)3.22620447
68double-strand break repair via nonhomologous end joining (GO:0006303)3.22620447
69drug transmembrane transport (GO:0006855)3.22033563
70regulation of meiosis I (GO:0060631)3.20284245
71nucleoside diphosphate biosynthetic process (GO:0009133)3.19540480
72histone exchange (GO:0043486)3.18829435
73glycine metabolic process (GO:0006544)3.17009304
74killing of cells of other organism (GO:0031640)3.16359142
75disruption of cells of other organism (GO:0044364)3.16359142
76water-soluble vitamin biosynthetic process (GO:0042364)3.16094917
77response to nitrosative stress (GO:0051409)3.14061109
78bile acid and bile salt transport (GO:0015721)3.12943957
79regulation of acyl-CoA biosynthetic process (GO:0050812)3.11532867
80regulation of protein activation cascade (GO:2000257)3.11346787
81nucleoside salvage (GO:0043174)3.11311602
82indolalkylamine metabolic process (GO:0006586)3.08948084
83serine family amino acid metabolic process (GO:0009069)3.08525329
84protein carboxylation (GO:0018214)3.07512508
85peptidyl-glutamic acid carboxylation (GO:0017187)3.07512508
86establishment of integrated proviral latency (GO:0075713)3.07461871
87NAD biosynthetic process (GO:0009435)3.07188782
88positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.06884649
89positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.06884649
90positive regulation of mitotic sister chromatid separation (GO:1901970)3.06884649
91ethanol oxidation (GO:0006069)3.06587485
92dicarboxylic acid biosynthetic process (GO:0043650)3.06496973
93phospholipid efflux (GO:0033700)3.05654994
94tricarboxylic acid metabolic process (GO:0072350)3.04838151
95piRNA metabolic process (GO:0034587)3.04765743
96urate metabolic process (GO:0046415)3.03339394
97DNA replication-dependent nucleosome assembly (GO:0006335)3.03166216
98DNA replication-dependent nucleosome organization (GO:0034723)3.03166216
99epithelial cilium movement (GO:0003351)3.03052670
100cellular ketone body metabolic process (GO:0046950)3.02872555
1012-oxoglutarate metabolic process (GO:0006103)3.02682852
102NADH metabolic process (GO:0006734)3.02614719
103metaphase plate congression (GO:0051310)3.02506009
104IMP biosynthetic process (GO:0006188)3.02002994
105regulation of fibrinolysis (GO:0051917)3.01949937
106protein K11-linked ubiquitination (GO:0070979)3.01784808
107NAD metabolic process (GO:0019674)3.01335304
108tricarboxylic acid cycle (GO:0006099)3.00181876
109peroxisome fission (GO:0016559)3.00047257
110postreplication repair (GO:0006301)3.00002180
111cofactor catabolic process (GO:0051187)2.99407665
112complement activation, alternative pathway (GO:0006957)2.99260820
113mitotic metaphase plate congression (GO:0007080)2.98923784
114DNA ligation (GO:0006266)2.98753878
115cholesterol efflux (GO:0033344)2.98481175
116cellular amino acid catabolic process (GO:0009063)2.98361167
117pyrimidine nucleoside monophosphate biosynthetic process (GO:0009130)2.95632066
118serine family amino acid catabolic process (GO:0009071)2.95229237
119regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.94817972
120homocysteine metabolic process (GO:0050667)2.94393707
121respiratory chain complex IV assembly (GO:0008535)2.93490815
122AMP metabolic process (GO:0046033)2.91770703
123pteridine-containing compound biosynthetic process (GO:0042559)2.90693670
124regulation of coenzyme metabolic process (GO:0051196)2.90014977
125regulation of cofactor metabolic process (GO:0051193)2.90014977
126branched-chain amino acid catabolic process (GO:0009083)2.89970649
127mismatch repair (GO:0006298)2.89725238
128low-density lipoprotein particle remodeling (GO:0034374)2.88198618
129nicotinamide nucleotide biosynthetic process (GO:0019359)2.87304633
130pyridine nucleotide biosynthetic process (GO:0019363)2.87304633
131regulation of complement activation (GO:0030449)2.87304296
132proline transport (GO:0015824)2.86645426
133drug transport (GO:0015893)2.86285263
134ribosome assembly (GO:0042255)2.85872861
135flavonoid metabolic process (GO:0009812)2.85204664
136pyrimidine-containing compound salvage (GO:0008655)2.82591707
137pyrimidine nucleoside salvage (GO:0043097)2.82591707
138protein localization to kinetochore (GO:0034501)2.82165948
139somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.81701493
140isotype switching (GO:0045190)2.81701493
141somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.81701493
142protein K6-linked ubiquitination (GO:0085020)2.80951530
143protein neddylation (GO:0045116)2.80940144
144coenzyme catabolic process (GO:0009109)2.80246232
145pyrimidine nucleoside monophosphate metabolic process (GO:0009129)2.79982865
146acylglycerol homeostasis (GO:0055090)2.79687508
147triglyceride homeostasis (GO:0070328)2.79687508
148early endosome to late endosome transport (GO:0045022)2.77695295
149amino acid salvage (GO:0043102)2.75669796
150L-methionine salvage (GO:0071267)2.75669796
151L-methionine biosynthetic process (GO:0071265)2.75669796
152male meiosis I (GO:0007141)2.75036271
153DNA catabolic process, exonucleolytic (GO:0000738)2.74893380
154ketone body metabolic process (GO:1902224)2.71216397
155histone H2A ubiquitination (GO:0033522)2.70906274
156regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.69116812
157magnesium ion transport (GO:0015693)2.68124663
158mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.67295343
159establishment of chromosome localization (GO:0051303)2.65214474
160IMP metabolic process (GO:0046040)2.64043715
161DNA replication checkpoint (GO:0000076)2.63365199
162nucleobase biosynthetic process (GO:0046112)2.62758011
163purine nucleobase biosynthetic process (GO:0009113)2.62634629
164protein-chromophore linkage (GO:0018298)2.61042110
165nucleotide transmembrane transport (GO:1901679)2.60488491
166mitotic sister chromatid cohesion (GO:0007064)2.60395476
167histone mRNA metabolic process (GO:0008334)2.60223057
168exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.59727088
169ADP metabolic process (GO:0046031)2.58582314
170positive regulation of histone H3-K4 methylation (GO:0051571)2.58411983
171spindle checkpoint (GO:0031577)2.58123862
172negative regulation of DNA-dependent DNA replication (GO:2000104)2.57963796
173anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.57557204
174regulation of sulfur metabolic process (GO:0042762)2.56712494
175intraciliary transport (GO:0042073)2.56403720
176DNA replication-independent nucleosome assembly (GO:0006336)2.55834185
177DNA replication-independent nucleosome organization (GO:0034724)2.55834185
178nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.55215557
179negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.54419984
180lactate metabolic process (GO:0006089)2.54255037
181somatic diversification of immune receptors via somatic mutation (GO:0002566)2.54041065
182somatic hypermutation of immunoglobulin genes (GO:0016446)2.54041065
183L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.53744239
184tetrahydrofolate metabolic process (GO:0046653)2.53005652
185positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.51738096
186mitotic spindle checkpoint (GO:0071174)2.51304468
187centriole assembly (GO:0098534)2.51219674
188maturation of 5.8S rRNA (GO:0000460)2.49807051
189acrosome assembly (GO:0001675)2.48836314
190cilium movement (GO:0003341)2.48548938
191cellular respiration (GO:0045333)2.48446913
192positive regulation of chromosome segregation (GO:0051984)2.48123381
193organelle disassembly (GO:1903008)2.47287675
194transcription elongation from RNA polymerase I promoter (GO:0006362)2.46828427
195vitamin biosynthetic process (GO:0009110)2.45465703
196response to pheromone (GO:0019236)2.45462435

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse6.75729787
2RXR_22158963_ChIP-Seq_LIVER_Mouse4.24542411
3EGR1_23403033_ChIP-Seq_LIVER_Mouse4.11199679
4EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.80263671
5CEBPA_23403033_ChIP-Seq_LIVER_Mouse3.77578110
6PPARA_22158963_ChIP-Seq_LIVER_Mouse3.76927593
7CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.58556970
8E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.41802451
9NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.37173467
10KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.12469054
11GABP_17652178_ChIP-ChIP_JURKAT_Human3.01234366
12POU3F2_20337985_ChIP-ChIP_501MEL_Human2.99458975
13PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.90842852
14LXR_22158963_ChIP-Seq_LIVER_Mouse2.82413983
15VDR_22108803_ChIP-Seq_LS180_Human2.78882227
16ELF1_17652178_ChIP-ChIP_JURKAT_Human2.70628571
17E2F7_22180533_ChIP-Seq_HELA_Human2.69521151
18PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.65666599
19GATA1_22025678_ChIP-Seq_K562_Human2.53516483
20JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.50483805
21SALL1_21062744_ChIP-ChIP_HESCs_Human2.50085601
22MYC_18555785_ChIP-Seq_MESCs_Mouse2.48932895
23EST1_17652178_ChIP-ChIP_JURKAT_Human2.46319115
24FUS_26573619_Chip-Seq_HEK293_Human2.45118128
25MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.43770840
26FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.40578576
27HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.37249011
28IRF8_22096565_ChIP-ChIP_GC-B_Human2.36194800
29IGF1R_20145208_ChIP-Seq_DFB_Human2.36037959
30FLI1_27457419_Chip-Seq_LIVER_Mouse2.34860477
31HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.18744912
32EWS_26573619_Chip-Seq_HEK293_Human2.12196605
33ZFP57_27257070_Chip-Seq_ESCs_Mouse2.06809525
34CREB1_15753290_ChIP-ChIP_HEK293T_Human2.03562426
35IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.01315197
36FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.00681915
37MYC_18358816_ChIP-ChIP_MESCs_Mouse1.99052645
38SRF_21415370_ChIP-Seq_HL-1_Mouse1.93932108
39SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.93910642
40* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.90165739
41ETS1_20019798_ChIP-Seq_JURKAT_Human1.87368912
42PCGF2_27294783_Chip-Seq_ESCs_Mouse1.86967181
43ZNF274_21170338_ChIP-Seq_K562_Hela1.85936917
44FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.84622796
45VDR_23849224_ChIP-Seq_CD4+_Human1.80097809
46PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.79733081
47ELK1_19687146_ChIP-ChIP_HELA_Human1.75201056
48DCP1A_22483619_ChIP-Seq_HELA_Human1.73032416
49P300_19829295_ChIP-Seq_ESCs_Human1.71201938
50THAP11_20581084_ChIP-Seq_MESCs_Mouse1.69305774
51FOXP3_21729870_ChIP-Seq_TREG_Human1.65733906
52* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.65049374
53HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.64337191
54CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.61627574
55GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.59687055
56ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.57762123
57TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.57064618
58GABP_19822575_ChIP-Seq_HepG2_Human1.55009382
59MYC_19030024_ChIP-ChIP_MESCs_Mouse1.52716000
60ERG_20887958_ChIP-Seq_HPC-7_Mouse1.52492463
61KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.52279551
62NELFA_20434984_ChIP-Seq_ESCs_Mouse1.51965222
63RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.50158740
64FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.49722321
65EZH2_27294783_Chip-Seq_NPCs_Mouse1.48487549
66AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.48330084
67IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.47963868
68TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.47428378
69CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.43518287
70SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.41012073
71SUZ12_27294783_Chip-Seq_NPCs_Mouse1.40850405
72CTBP2_25329375_ChIP-Seq_LNCAP_Human1.40113824
73CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.40052992
74NANOG_19829295_ChIP-Seq_ESCs_Human1.39895361
75SOX2_19829295_ChIP-Seq_ESCs_Human1.39895361
76GBX2_23144817_ChIP-Seq_PC3_Human1.39474008
77MYB_21317192_ChIP-Seq_ERMYB_Mouse1.38511596
78NFE2_27457419_Chip-Seq_LIVER_Mouse1.36768101
79ER_23166858_ChIP-Seq_MCF-7_Human1.36005066
80MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.34831169
81RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.34058099
82XRN2_22483619_ChIP-Seq_HELA_Human1.33621352
83CTBP1_25329375_ChIP-Seq_LNCAP_Human1.33579753
84IRF8_21731497_ChIP-ChIP_J774_Mouse1.33436596
85MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.31916916
86SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.30838923
87YY1_21170310_ChIP-Seq_MESCs_Mouse1.30088875
88ZFX_18555785_ChIP-Seq_MESCs_Mouse1.29036444
89SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.26743079
90SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.24511774
91AR_21909140_ChIP-Seq_LNCAP_Human1.22542697
92OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.21478794
93CDX2_22108803_ChIP-Seq_LS180_Human1.21068314
94NANOG_18555785_Chip-Seq_ESCs_Mouse1.19809029
95IRF1_19129219_ChIP-ChIP_H3396_Human1.19455458
96UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.19130970
97PCGF2_27294783_Chip-Seq_NPCs_Mouse1.19087743
98TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.17562815
99SMAD4_21799915_ChIP-Seq_A2780_Human1.17530360
100CRX_20693478_ChIP-Seq_RETINA_Mouse1.14784008
101CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.14701498
102STAT4_19710469_ChIP-ChIP_TH1__Mouse1.14369684
103ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.13741144
104EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.13480511
105PIAS1_25552417_ChIP-Seq_VCAP_Human1.12993724
106SMAD3_21741376_ChIP-Seq_EPCs_Human1.12967708
107GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.12694108
108BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.12490785
109TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.11584743
110PADI4_21655091_ChIP-ChIP_MCF-7_Human1.11196601
111TCF4_22108803_ChIP-Seq_LS180_Human1.10746638
112STAT3_23295773_ChIP-Seq_U87_Human1.10542570
113EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.10478267
114MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.08516529
115SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.06066322
116TAL1_26923725_Chip-Seq_HPCs_Mouse1.05622003
117CBP_20019798_ChIP-Seq_JUKART_Human1.05386988
118IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.05386988
119P53_22387025_ChIP-Seq_ESCs_Mouse1.05110051
120E2F4_17652178_ChIP-ChIP_JURKAT_Human1.04780342
121MYC_19079543_ChIP-ChIP_MESCs_Mouse1.04471966
122NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.04177814
123STAT3_18555785_Chip-Seq_ESCs_Mouse1.03949333
124SPI1_23547873_ChIP-Seq_NB4_Human1.03667527
125SUZ12_18555785_Chip-Seq_ESCs_Mouse1.03462891
126ESR1_15608294_ChIP-ChIP_MCF-7_Human1.03035873
127ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.02977646
128* FOXA1_25329375_ChIP-Seq_VCAP_Human1.02514502
129* FOXA1_27270436_Chip-Seq_PROSTATE_Human1.02514502
130E2F1_18555785_Chip-Seq_ESCs_Mouse1.02514255
131NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.01366583
132HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.01052510
133CMYC_18555785_Chip-Seq_ESCs_Mouse1.00945018
134P300_18555785_Chip-Seq_ESCs_Mouse0.99484936
135SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.99461621
136NMYC_18555785_Chip-Seq_ESCs_Mouse0.98783539
137* FOXM1_26456572_ChIP-Seq_MCF-7_Human0.98265613
138TOP2B_26459242_ChIP-Seq_MCF-7_Human0.98254064
139TP53_22573176_ChIP-Seq_HFKS_Human0.97598346
140SOX2_18555785_Chip-Seq_ESCs_Mouse0.96825994
141SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.95820825
142STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.95744869
143* PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.90457897
144EGR1_19374776_ChIP-ChIP_THP-1_Human0.90153469
145HTT_18923047_ChIP-ChIP_STHdh_Human0.88521908
146TAF15_26573619_Chip-Seq_HEK293_Human0.88011079
147* FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.83727446
148GATA2_22383799_ChIP-Seq_G1ME_Mouse0.82858313
149TFEB_21752829_ChIP-Seq_HELA_Human0.82777918
150MYB_26560356_Chip-Seq_TH2_Human0.79858874
151MYC_18940864_ChIP-ChIP_HL60_Human0.79082937
152CTCF_18555785_ChIP-Seq_MESCs_Mouse0.78481425
153NOTCH1_21737748_ChIP-Seq_TLL_Human0.77337114
154AR_20517297_ChIP-Seq_VCAP_Human0.76886463
155YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.76680031
156E2F1_21310950_ChIP-Seq_MCF-7_Human0.75934582
157LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.75466212
158POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.75432550
159TTF2_22483619_ChIP-Seq_HELA_Human0.75428612
160SALL4_22934838_ChIP-ChIP_CD34+_Human0.75117199
161FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.74348488
162MYCN_18555785_ChIP-Seq_MESCs_Mouse0.73075564
163CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.72895120
164RBPJ_22232070_ChIP-Seq_NCS_Mouse0.72765810
165ELK1_22589737_ChIP-Seq_MCF10A_Human0.71477776
166NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.69588989

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis6.40323935
2MP0002139_abnormal_hepatobiliary_system6.24668053
3MP0005085_abnormal_gallbladder_physiolo4.87123355
4MP0005365_abnormal_bile_salt4.66057029
5MP0003806_abnormal_nucleotide_metabolis4.53196126
6MP0008875_abnormal_xenobiotic_pharmacok4.41205708
7MP0003011_delayed_dark_adaptation3.52336837
8MP0010329_abnormal_lipoprotein_level2.88420042
9MP0006072_abnormal_retinal_apoptosis2.86886116
10MP0002638_abnormal_pupillary_reflex2.80414270
11MP0003195_calcinosis2.78033802
12MP0003252_abnormal_bile_duct2.71782969
13MP0010094_abnormal_chromosome_stability2.68261589
14MP0008058_abnormal_DNA_repair2.65678756
15MP0003718_maternal_effect2.51545620
16MP0003186_abnormal_redox_activity2.51338135
17MP0009697_abnormal_copulation2.43581006
18MP0001666_abnormal_nutrient_absorption2.41129207
19MP0010234_abnormal_vibrissa_follicle2.36131885
20MP0008057_abnormal_DNA_replication2.34076003
21MP0005332_abnormal_amino_acid2.34009747
22MP0008877_abnormal_DNA_methylation2.28294759
23MP0006036_abnormal_mitochondrial_physio2.17708577
24MP0002837_dystrophic_cardiac_calcinosis2.14526885
25MP0002160_abnormal_reproductive_system2.01829145
26MP0001764_abnormal_homeostasis1.98526173
27MP0002102_abnormal_ear_morphology1.97917865
28MP0005379_endocrine/exocrine_gland_phen1.95224059
29MP0005253_abnormal_eye_physiology1.93390957
30MP0005584_abnormal_enzyme/coenzyme_acti1.93058638
31MP0005174_abnormal_tail_pigmentation1.83824040
32MP0003656_abnormal_erythrocyte_physiolo1.81836925
33MP0001529_abnormal_vocalization1.80895284
34MP0005319_abnormal_enzyme/_coenzyme1.80720353
35MP0000569_abnormal_digit_pigmentation1.78871685
36MP0004215_abnormal_myocardial_fiber1.70728778
37MP0000609_abnormal_liver_physiology1.68186805
38MP0005083_abnormal_biliary_tract1.65840993
39MP0009840_abnormal_foam_cell1.62703580
40MP0003191_abnormal_cellular_cholesterol1.59704052
41MP0003111_abnormal_nucleus_morphology1.56635677
42MP0003724_increased_susceptibility_to1.55204200
43MP0004147_increased_porphyrin_level1.53528869
44MP0002138_abnormal_hepatobiliary_system1.53057637
45MP0005636_abnormal_mineral_homeostasis1.50621057
46MP0009643_abnormal_urine_homeostasis1.50212632
47MP0003890_abnormal_embryonic-extraembry1.47588133
48MP0002928_abnormal_bile_duct1.46942906
49MP0002118_abnormal_lipid_homeostasis1.45635254
50MP0003693_abnormal_embryo_hatching1.44463336
51MP0009785_altered_susceptibility_to1.44179995
52MP0005551_abnormal_eye_electrophysiolog1.43683502
53MP0006035_abnormal_mitochondrial_morpho1.43070369
54MP0003868_abnormal_feces_composition1.40909302
55MP0002163_abnormal_gland_morphology1.35106457
56MP0008932_abnormal_embryonic_tissue1.35049999
57MP0001835_abnormal_antigen_presentation1.34990055
58MP0005084_abnormal_gallbladder_morpholo1.34080856
59MP0003077_abnormal_cell_cycle1.33887843
60MP0005408_hypopigmentation1.33510277
61MP0003786_premature_aging1.30906660
62MP0002090_abnormal_vision1.24701089
63MP0001188_hyperpigmentation1.23996180
64MP0002234_abnormal_pharynx_morphology1.23739768
65MP0001986_abnormal_taste_sensitivity1.21912501
66MP0008469_abnormal_protein_level1.20082590
67MP0000427_abnormal_hair_cycle1.18636977
68MP0004043_abnormal_pH_regulation1.18509465
69MP0003943_abnormal_hepatobiliary_system1.18153799
70MP0001501_abnormal_sleep_pattern1.18110220
71MP0004019_abnormal_vitamin_homeostasis1.17624727
72MP0001984_abnormal_olfaction1.16590217
73MP0000015_abnormal_ear_pigmentation1.13354257
74MP0000598_abnormal_liver_morphology1.12952231
75MP0005266_abnormal_metabolism1.11777170
76MP0003436_decreased_susceptibility_to1.10498792
77MP0001929_abnormal_gametogenesis1.09817926
78MP0005389_reproductive_system_phenotype1.09694219
79MP0005671_abnormal_response_to1.06637049
80MP0003172_abnormal_lysosome_physiology1.06391117
81MP0004264_abnormal_extraembryonic_tissu1.06078322
82MP0002735_abnormal_chemical_nociception1.05551246
83MP0003136_yellow_coat_color1.04690346
84MP0003183_abnormal_peptide_metabolism1.04525366
85MP0002210_abnormal_sex_determination1.04297854
86MP0005058_abnormal_lysosome_morphology1.03946867
87MP0002736_abnormal_nociception_after1.02875156
88MP0002909_abnormal_adrenal_gland1.01238361
89MP0002876_abnormal_thyroid_physiology1.00419773
90MP0008789_abnormal_olfactory_epithelium0.99392981
91MP0008872_abnormal_physiological_respon0.98992281
92MP0005464_abnormal_platelet_physiology0.97856225
93MP0005376_homeostasis/metabolism_phenot0.97091529
94MP0003866_abnormal_defecation0.97019934
95MP0003880_abnormal_central_pattern0.96572864
96MP0010386_abnormal_urinary_bladder0.95509994
97MP0009765_abnormal_xenobiotic_induced0.94880264
98MP0009642_abnormal_blood_homeostasis0.92394313
99MP0008007_abnormal_cellular_replicative0.91707089
100MP0009763_increased_sensitivity_to0.91648524
101MP0009764_decreased_sensitivity_to0.91532070
102MP0003567_abnormal_fetal_cardiomyocyte0.91410177
103MP0001145_abnormal_male_reproductive0.90569882
104MP0001853_heart_inflammation0.90487376
105MP0000653_abnormal_sex_gland0.90105999
106MP0001502_abnormal_circadian_rhythm0.88729650
107MP0002006_tumorigenesis0.88711850
108MP0001845_abnormal_inflammatory_respons0.88499219
109MP0002132_abnormal_respiratory_system0.88468200
110MP0010155_abnormal_intestine_physiology0.88221060
111MP0002938_white_spotting0.87875768
112MP0010352_gastrointestinal_tract_polyps0.86865069
113MP0001905_abnormal_dopamine_level0.85548721
114MP0005025_abnormal_response_to0.85483342
115MP0002078_abnormal_glucose_homeostasis0.85468147
116MP0002822_catalepsy0.84345953
117MP0004782_abnormal_surfactant_physiolog0.83856883
118MP0002419_abnormal_innate_immunity0.82403534
119MP0006082_CNS_inflammation0.81123820
120MP0000372_irregular_coat_pigmentation0.80870474
121MP0005171_absent_coat_pigmentation0.79886926
122MP0002095_abnormal_skin_pigmentation0.79634361
123MP0005499_abnormal_olfactory_system0.79477536
124MP0005394_taste/olfaction_phenotype0.79477536
125MP0008873_increased_physiological_sensi0.77737258
126MP0005391_vision/eye_phenotype0.77142914
127MP0001800_abnormal_humoral_immune0.75722382
128MP0009046_muscle_twitch0.74987582
129MP0001968_abnormal_touch/_nociception0.74412854
130MP0005395_other_phenotype0.73838451
131MP0001756_abnormal_urination0.73806213
132MP0005647_abnormal_sex_gland0.73633904
133MP0001324_abnormal_eye_pigmentation0.72551233
134MP0004957_abnormal_blastocyst_morpholog0.72228448
135MP0000604_amyloidosis0.71454333
136MP0003698_abnormal_male_reproductive0.70936427
137MP0005000_abnormal_immune_tolerance0.70164523
138MP0002723_abnormal_immune_serum0.69979957
139MP0005645_abnormal_hypothalamus_physiol0.69905905
140MP0006054_spinal_hemorrhage0.69643964
141MP0002420_abnormal_adaptive_immunity0.69606769
142MP0005075_abnormal_melanosome_morpholog0.68943252
143MP0001293_anophthalmia0.68901467
144MP0001819_abnormal_immune_cell0.68705003
145MP0005220_abnormal_exocrine_pancreas0.68254152
146MP0005535_abnormal_body_temperature0.67814828
147MP0010307_abnormal_tumor_latency0.65758303
148MP0009379_abnormal_foot_pigmentation0.64477474
149MP0000689_abnormal_spleen_morphology0.63860960
150MP0001663_abnormal_digestive_system0.63200368
151MP0001730_embryonic_growth_arrest0.63102444
152MP0003879_abnormal_hair_cell0.62962486
153MP0002751_abnormal_autonomic_nervous0.62367515
154MP0008775_abnormal_heart_ventricle0.62007798
155MP0000358_abnormal_cell_content/0.61785405
156MP0001765_abnormal_ion_homeostasis0.60261480
157MP0002398_abnormal_bone_marrow0.59859544
158MP0000716_abnormal_immune_system0.59684416
159MP0000013_abnormal_adipose_tissue0.59644961
160MP0000685_abnormal_immune_system0.58370405
161MP0002429_abnormal_blood_cell0.58166512
162MP0002722_abnormal_immune_system0.58142165
163MP0002452_abnormal_antigen_presenting0.57702551
164MP0002693_abnormal_pancreas_physiology0.57154185
165MP0002148_abnormal_hypersensitivity_rea0.57146706
166MP0000490_abnormal_crypts_of0.55821396
167MP0002136_abnormal_kidney_physiology0.55613608
168MP0003763_abnormal_thymus_physiology0.54036064

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)5.69257517
2Hypobetalipoproteinemia (HP:0003563)5.04461130
3Abnormality of monocarboxylic acid metabolism (HP:0010996)4.55033645
4Intrahepatic cholestasis (HP:0001406)4.37344149
5Prolonged partial thromboplastin time (HP:0003645)3.82562706
6Deep venous thrombosis (HP:0002625)3.75141588
7Xanthomatosis (HP:0000991)3.45484613
8Hypoglycemic coma (HP:0001325)3.38366999
9Abnormality of pyrimidine metabolism (HP:0004353)3.27406734
10Fat malabsorption (HP:0002630)3.25075751
11Hyperlipoproteinemia (HP:0010980)3.25011289
12Hyperammonemia (HP:0001987)3.20081014
13Cerebral edema (HP:0002181)3.19453980
14Hypothermia (HP:0002045)3.15727882
15Short tibia (HP:0005736)3.13441690
16Hepatic necrosis (HP:0002605)3.12427985
17Hyperbilirubinemia (HP:0002904)3.12396699
18Conjugated hyperbilirubinemia (HP:0002908)3.09303500
19Acute encephalopathy (HP:0006846)3.06687751
20Abnormality of glutamine family amino acid metabolism (HP:0010902)3.06219542
21Ketosis (HP:0001946)3.02450336
22Abnormality of methionine metabolism (HP:0010901)3.02012561
23Generalized aminoaciduria (HP:0002909)3.01742547
24Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.00193802
25Abnormal mitochondria in muscle tissue (HP:0008316)3.00086368
26Abnormality of aspartate family amino acid metabolism (HP:0010899)2.99818137
27Abnormality of the common coagulation pathway (HP:0010990)2.99026764
28Medial flaring of the eyebrow (HP:0010747)2.98419840
29Hypolipoproteinemia (HP:0010981)2.96557309
30Renal cortical cysts (HP:0000803)2.94988212
31Hepatocellular necrosis (HP:0001404)2.94353422
32Abnormality of fatty-acid metabolism (HP:0004359)2.90749791
33Acute necrotizing encephalopathy (HP:0006965)2.87711441
34Aplasia/Hypoplasia of the tibia (HP:0005772)2.84946452
35Abnormality of sulfur amino acid metabolism (HP:0004339)2.84624320
363-Methylglutaconic aciduria (HP:0003535)2.82443884
37Degeneration of anterior horn cells (HP:0002398)2.80682809
38Abnormality of the anterior horn cell (HP:0006802)2.80682809
39Pancreatic fibrosis (HP:0100732)2.78405380
40Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.78312530
41Spastic diplegia (HP:0001264)2.73915168
42Decreased activity of mitochondrial respiratory chain (HP:0008972)2.73321550
43Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.73321550
44Methylmalonic acidemia (HP:0002912)2.73295274
45Abnormality of vitamin B metabolism (HP:0004340)2.70839826
46Lethargy (HP:0001254)2.68097971
47Increased CSF lactate (HP:0002490)2.67742483
48Abnormality of the renal cortex (HP:0011035)2.66651023
49Abnormality of nucleobase metabolism (HP:0010932)2.60622646
50Nephronophthisis (HP:0000090)2.60054890
51Abnormality of the intrinsic pathway (HP:0010989)2.59309978
52Supernumerary spleens (HP:0009799)2.57165974
53Hyperglycinemia (HP:0002154)2.55812404
54Acanthocytosis (HP:0001927)2.54066954
55Mitochondrial inheritance (HP:0001427)2.53593968
56Steatorrhea (HP:0002570)2.50691302
57Increased serum pyruvate (HP:0003542)2.46529603
58Abnormality of glycolysis (HP:0004366)2.46529603
59Ketoacidosis (HP:0001993)2.46317133
60Dicarboxylic aciduria (HP:0003215)2.45339723
61Abnormality of dicarboxylic acid metabolism (HP:0010995)2.45339723
62Abnormality of glycine metabolism (HP:0010895)2.42249205
63Abnormality of serine family amino acid metabolism (HP:0010894)2.42249205
64Congenital primary aphakia (HP:0007707)2.40778083
65Recurrent gram-negative bacterial infections (HP:0005420)2.40573180
66Progressive macrocephaly (HP:0004481)2.38464417
67Neuroendocrine neoplasm (HP:0100634)2.38349503
68Abnormality of chromosome stability (HP:0003220)2.36239730
69Abnormality of midbrain morphology (HP:0002418)2.35559193
70Molar tooth sign on MRI (HP:0002419)2.35559193
71Lactic acidosis (HP:0003128)2.35180542
72Hypoglycemic seizures (HP:0002173)2.35060407
73Metabolic acidosis (HP:0001942)2.33338811
74Azoospermia (HP:0000027)2.32978792
75Gait imbalance (HP:0002141)2.32198807
76Abnormal ciliary motility (HP:0012262)2.31405970
77Pheochromocytoma (HP:0002666)2.30953855
78Reduced antithrombin III activity (HP:0001976)2.30654969
79Joint hemorrhage (HP:0005261)2.30571953
80Hyperglycinuria (HP:0003108)2.29575042
81Ragged-red muscle fibers (HP:0003200)2.29031572
82Abnormality of purine metabolism (HP:0004352)2.27230602
83Pancreatic cysts (HP:0001737)2.25983434
84Rhinitis (HP:0012384)2.25571548
85Atrophy/Degeneration involving motor neurons (HP:0007373)2.25396094
86Nephrogenic diabetes insipidus (HP:0009806)2.24958095
87Gout (HP:0001997)2.22313093
88Complement deficiency (HP:0004431)2.22121023
89Hepatocellular carcinoma (HP:0001402)2.21759840
90Microvesicular hepatic steatosis (HP:0001414)2.21459456
91Abnormal respiratory motile cilium physiology (HP:0012261)2.20400881
92Abnormality of the vitamin B12 metabolism (HP:0004341)2.20038350
93Abnormality of vitamin metabolism (HP:0100508)2.19108285
94Lipid accumulation in hepatocytes (HP:0006561)2.18701859
95Abnormality of serum amino acid levels (HP:0003112)2.17433759
96Bile duct proliferation (HP:0001408)2.16646403
97Abnormal biliary tract physiology (HP:0012439)2.16646403
98Increased serum lactate (HP:0002151)2.16384333
99Hyperglycemia (HP:0003074)2.16281547
100Acute hepatic failure (HP:0006554)2.15641886
101Increased hepatocellular lipid droplets (HP:0006565)2.15564681
102Vomiting (HP:0002013)2.15120603
103Hypercholesterolemia (HP:0003124)2.14947338
104Opisthotonus (HP:0002179)2.14377486
105Chromosomal breakage induced by crosslinking agents (HP:0003221)2.13904777
106Chromsome breakage (HP:0040012)2.13646291
107Colon cancer (HP:0003003)2.13187282
108Delayed CNS myelination (HP:0002188)2.11321201
109Megaloblastic anemia (HP:0001889)2.09927366
110Abnormal spermatogenesis (HP:0008669)2.09687664
111Agnosia (HP:0010524)2.09106628
112Absent/shortened dynein arms (HP:0200106)2.08682537
113Dynein arm defect of respiratory motile cilia (HP:0012255)2.08682537
114Abnormal respiratory motile cilium morphology (HP:0005938)2.08374419
115Abnormal respiratory epithelium morphology (HP:0012253)2.08374419
116Biliary tract neoplasm (HP:0100574)2.07882886
117Median cleft lip (HP:0000161)2.04703041
118Genital tract atresia (HP:0001827)2.04363075
119Symptomatic seizures (HP:0011145)2.02443154
120Volvulus (HP:0002580)2.01411042
121True hermaphroditism (HP:0010459)2.00733289
122Irritability (HP:0000737)2.00255364
123Rhabdomyosarcoma (HP:0002859)1.99346890
124Sensorimotor neuropathy (HP:0007141)1.98836797
125Neonatal onset (HP:0003623)1.98194570
126Brushfield spots (HP:0001088)1.98174778
127Cholecystitis (HP:0001082)1.98039547
128Abnormal gallbladder physiology (HP:0012438)1.98039547
129Abnormality of iron homeostasis (HP:0011031)1.96155545
130Abnormality of the renal medulla (HP:0100957)1.95352678
131Glycosuria (HP:0003076)1.95331943
132Abnormality of urine glucose concentration (HP:0011016)1.95331943
133Pancreatic islet-cell hyperplasia (HP:0004510)1.94611413
134CNS demyelination (HP:0007305)1.92641731
135Abnormal gallbladder morphology (HP:0012437)1.91989558
136Respiratory failure (HP:0002878)1.90366792
137Epidermoid cyst (HP:0200040)1.90268975
138Proximal tubulopathy (HP:0000114)1.89757130
139Malnutrition (HP:0004395)1.89397487
140Intestinal atresia (HP:0011100)1.87368733
141Epiphyseal stippling (HP:0010655)1.87198763
142Abnormality of transition element cation homeostasis (HP:0011030)1.87100908
143Abnormal hair whorl (HP:0010721)1.83882974
144Hyperventilation (HP:0002883)1.83672878
145Hypoplasia of the thymus (HP:0000778)1.83311869
146Metaphyseal dysplasia (HP:0100255)1.82689115
147Aplasia/Hypoplasia of the uvula (HP:0010293)1.81806542
148Poikilocytosis (HP:0004447)1.81632834
149Abnormality of the preputium (HP:0100587)1.81008591
150Hyperinsulinemic hypoglycemia (HP:0000825)1.80849183
151Alkalosis (HP:0001948)1.80386703
152Hypoplasia of the fovea (HP:0007750)1.79448590
153Aplasia/Hypoplasia of the fovea (HP:0008060)1.79448590
154Methylmalonic aciduria (HP:0012120)1.79385243
155Late onset (HP:0003584)1.78564481
156Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.77874103
157Abnormality of alanine metabolism (HP:0010916)1.77874103
158Hyperalaninemia (HP:0003348)1.77874103
159Cholelithiasis (HP:0001081)1.77548708
160Abnormal biliary tract morphology (HP:0012440)1.77387293
161Death in childhood (HP:0003819)1.76028610
162Aplasia/Hypoplasia of the tongue (HP:0010295)1.74676057
163Abnormality of the fovea (HP:0000493)1.74395620
164Abnormality of the labia minora (HP:0012880)1.74023036
165Meckel diverticulum (HP:0002245)1.72994660
166Progressive inability to walk (HP:0002505)1.72650484
167Tetraplegia (HP:0002445)1.72622176

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K123.92014584
2MKNK23.34180826
3TNIK3.09292504
4ERBB33.00743471
5EIF2AK12.87983269
6BCKDK2.71411106
7SCYL22.40778916
8EIF2AK32.37334519
9TESK12.33555057
10TESK22.29627145
11TAF12.28701837
12TRIM282.26665345
13STK162.21824744
14CCNB12.18129386
15MAP4K22.10161608
16NEK12.04553963
17STK392.00023870
18PBK1.98780020
19MKNK11.90803998
20TTK1.86313343
21STK241.85874665
22TSSK61.80795702
23FRK1.76338661
24CAMKK21.70054335
25MAP2K41.69589447
26FLT31.65666411
27DAPK11.61659467
28ZAK1.57758249
29CDK191.57604030
30BCR1.56221647
31PINK11.55919642
32ARAF1.49822053
33MAP2K71.39943404
34BRSK21.39097953
35MAP2K31.38784115
36MST1R1.38478359
37NUAK11.32905465
38PIM21.32765575
39LIMK11.31718974
40MAP3K91.29877696
41TXK1.27188142
42MAP3K141.24864619
43WNK41.24339747
44MAP3K111.24305195
45NME21.23985102
46GRK61.23257638
47ZAP701.21957200
48BRSK11.21870086
49KDR1.20416151
50WEE11.18312592
51TLK11.17093177
52BRD41.16727181
53STK31.14035000
54MAP4K11.12369423
55CASK1.12212992
56MST41.10700767
57PLK41.09753503
58BUB11.09202806
59MYLK1.08386517
60TEC1.06736466
61ACVR1B1.04619116
62STK38L1.04285973
63PDK41.03746852
64PDK31.03746852
65TYK21.03335911
66MINK11.02787026
67INSRR0.98209099
68SYK0.97354713
69BMPR20.97335431
70ITK0.95784583
71FGFR40.94561897
72PASK0.94217381
73PLK10.92496837
74PLK20.91760075
75TBK10.89650758
76WNK30.89501217
77PNCK0.89074014
78VRK10.88819741
79PIK3CG0.88625835
80KIT0.88361789
81SIK30.86748628
82BRAF0.84633456
83MAP3K20.83015279
84MAP2K60.81397127
85BMPR1B0.77893091
86PRKCG0.77327211
87DYRK30.76909989
88YES10.74924736
89TGFBR10.73824539
90ADRBK20.72050212
91RPS6KA40.70919623
92BTK0.69961039
93CSNK1G20.68331492
94OBSCN0.67525674
95NEK90.67037291
96CSNK1G10.66106679
97CAMKK10.63975892
98TAOK30.63417546
99EIF2AK20.61939913
100GRK10.61886956
101ABL20.61737070
102KSR20.60916933
103TAOK20.56523954
104FES0.56257577
105ERBB40.56198356
106NEK20.56060136
107CSNK1G30.54943186
108DAPK20.52786510
109LYN0.51921818
110PDK20.50458573
111PRKCE0.50176318
112OXSR10.49658994
113ATM0.49347126
114MAP3K130.48512029
115ERN10.48100194
116MAP3K10.47698134
117PHKG10.47130419
118PHKG20.47130419
119MAP3K40.46656405
120CDK30.46285322
121PLK30.45803319
122RIPK40.45265595
123NLK0.45262941
124FER0.43159884
125NEK60.42856426
126SRPK10.41921467
127CDC70.41737459
128ALK0.40952748
129CDK90.40574358
130CSNK1A1L0.40412345
131NME10.39225312
132MAPK110.39126730
133NTRK30.38619227
134MAPK130.38517373
135PRKCD0.38352454
136AURKB0.37963548
137LCK0.37784180
138PRKCQ0.37565422
139CDK80.37309382
140RAF10.36857323
141CAMK2A0.35546749
142PRKG20.35315936
143ATR0.35053607
144MAP3K50.33618538
145MAP3K30.33405007
146RPS6KB10.33188365
147MARK30.32142062
148MATK0.32110442
149LRRK20.32098281
150FGFR10.31491195
151CSNK2A10.31261505
152CSF1R0.30696474
153DYRK1A0.30677109
154CSNK1E0.30001944
155MAP2K10.29654235
156STK100.28752943
157CHEK20.28581505
158PIK3CA0.27185383

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.45789185
2Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.36446597
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.27694306
4Nitrogen metabolism_Homo sapiens_hsa009102.90917337
5Drug metabolism - other enzymes_Homo sapiens_hsa009832.60165540
6Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.57774096
7Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.56020274
8Pentose and glucuronate interconversions_Homo sapiens_hsa000402.51603537
9Arginine biosynthesis_Homo sapiens_hsa002202.35741751
102-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.32020409
11Sulfur metabolism_Homo sapiens_hsa009202.23146930
12Non-homologous end-joining_Homo sapiens_hsa034502.10082442
13Pyruvate metabolism_Homo sapiens_hsa006202.06918688
14Basal transcription factors_Homo sapiens_hsa030222.05809327
15Tryptophan metabolism_Homo sapiens_hsa003801.98026258
16Peroxisome_Homo sapiens_hsa041461.96424679
17Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.94015988
18Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.90315548
19Fatty acid degradation_Homo sapiens_hsa000711.81855902
20Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.80218699
21Homologous recombination_Homo sapiens_hsa034401.79332185
22Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.77991462
23Proteasome_Homo sapiens_hsa030501.77383627
24Carbon metabolism_Homo sapiens_hsa012001.75420816
25Cysteine and methionine metabolism_Homo sapiens_hsa002701.75019337
26Vitamin B6 metabolism_Homo sapiens_hsa007501.73598472
27Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.72458488
28Biosynthesis of amino acids_Homo sapiens_hsa012301.68650467
29Selenocompound metabolism_Homo sapiens_hsa004501.68100531
30Folate biosynthesis_Homo sapiens_hsa007901.67147326
31Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.67083471
32Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.66861370
33Caffeine metabolism_Homo sapiens_hsa002321.64824008
34Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.59538707
35RNA polymerase_Homo sapiens_hsa030201.58429908
36Propanoate metabolism_Homo sapiens_hsa006401.58381758
37Chemical carcinogenesis_Homo sapiens_hsa052041.56348141
38RNA degradation_Homo sapiens_hsa030181.56325782
39Fanconi anemia pathway_Homo sapiens_hsa034601.54702382
40Complement and coagulation cascades_Homo sapiens_hsa046101.50722960
41Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.48276978
42Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.47099496
43Butanoate metabolism_Homo sapiens_hsa006501.46340221
44Steroid hormone biosynthesis_Homo sapiens_hsa001401.42860303
45RNA transport_Homo sapiens_hsa030131.42247278
46Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.41802279
47Histidine metabolism_Homo sapiens_hsa003401.39615334
48Circadian rhythm_Homo sapiens_hsa047101.33387711
49Maturity onset diabetes of the young_Homo sapiens_hsa049501.32611935
50Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.30285740
51Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.27240274
52Pentose phosphate pathway_Homo sapiens_hsa000301.25573029
53Starch and sucrose metabolism_Homo sapiens_hsa005001.24264412
54Cyanoamino acid metabolism_Homo sapiens_hsa004601.24202187
55Oxidative phosphorylation_Homo sapiens_hsa001901.22373054
56DNA replication_Homo sapiens_hsa030301.19476153
57One carbon pool by folate_Homo sapiens_hsa006701.17403753
58Sulfur relay system_Homo sapiens_hsa041221.15381557
59beta-Alanine metabolism_Homo sapiens_hsa004101.14283321
60Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.14187714
61Bile secretion_Homo sapiens_hsa049761.10408081
62Retinol metabolism_Homo sapiens_hsa008301.08373144
63Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.07162718
64Cell cycle_Homo sapiens_hsa041101.06451660
65Linoleic acid metabolism_Homo sapiens_hsa005911.05726041
66Protein export_Homo sapiens_hsa030601.05659859
67Fatty acid metabolism_Homo sapiens_hsa012121.02685395
68Phenylalanine metabolism_Homo sapiens_hsa003601.00421244
69Glutathione metabolism_Homo sapiens_hsa004800.98378162
70Oocyte meiosis_Homo sapiens_hsa041140.98155982
71Collecting duct acid secretion_Homo sapiens_hsa049660.96463567
72Regulation of autophagy_Homo sapiens_hsa041400.96129352
73Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.95494212
74PPAR signaling pathway_Homo sapiens_hsa033200.92565343
75Spliceosome_Homo sapiens_hsa030400.92044226
76Parkinsons disease_Homo sapiens_hsa050120.91022709
77Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.89738346
78Tyrosine metabolism_Homo sapiens_hsa003500.87953888
79ABC transporters_Homo sapiens_hsa020100.82142226
80Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.79050308
81Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.77126476
82Staphylococcus aureus infection_Homo sapiens_hsa051500.75936306
83Pyrimidine metabolism_Homo sapiens_hsa002400.74473783
84Mismatch repair_Homo sapiens_hsa034300.71261829
85Arginine and proline metabolism_Homo sapiens_hsa003300.70967838
86Synaptic vesicle cycle_Homo sapiens_hsa047210.66398183
87Fatty acid elongation_Homo sapiens_hsa000620.65401522
88Fructose and mannose metabolism_Homo sapiens_hsa000510.64924530
89* Metabolic pathways_Homo sapiens_hsa011000.64918211
90Vibrio cholerae infection_Homo sapiens_hsa051100.64582664
91Phototransduction_Homo sapiens_hsa047440.63330482
92Vitamin digestion and absorption_Homo sapiens_hsa049770.60603782
93Galactose metabolism_Homo sapiens_hsa000520.59712363
94Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.59534298
95Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.57509396
96Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.57434300
97Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.56432814
98Fat digestion and absorption_Homo sapiens_hsa049750.55916417
99Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.55440129
100Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.53945275
101N-Glycan biosynthesis_Homo sapiens_hsa005100.52718612
102Mineral absorption_Homo sapiens_hsa049780.51255080
103Ether lipid metabolism_Homo sapiens_hsa005650.47993670
104Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.46884382
105Alzheimers disease_Homo sapiens_hsa050100.46662059
106mRNA surveillance pathway_Homo sapiens_hsa030150.45691263
107Sphingolipid metabolism_Homo sapiens_hsa006000.44944478
108Arachidonic acid metabolism_Homo sapiens_hsa005900.44131458
109Ribosome_Homo sapiens_hsa030100.43568397
110alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.39882855
111Primary immunodeficiency_Homo sapiens_hsa053400.38592670
112Legionellosis_Homo sapiens_hsa051340.37959036
113Antigen processing and presentation_Homo sapiens_hsa046120.37662382
114Type I diabetes mellitus_Homo sapiens_hsa049400.35601818
115Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.34022938
116Huntingtons disease_Homo sapiens_hsa050160.32810738
117Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.32420047
118p53 signaling pathway_Homo sapiens_hsa041150.30920862
119Cardiac muscle contraction_Homo sapiens_hsa042600.29354062
120Phagosome_Homo sapiens_hsa041450.29216765
121Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.28993856
122Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.28590663
123SNARE interactions in vesicular transport_Homo sapiens_hsa041300.26603504
124Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.21586578
125Nucleotide excision repair_Homo sapiens_hsa034200.17081499
126Steroid biosynthesis_Homo sapiens_hsa001000.14490520
127Purine metabolism_Homo sapiens_hsa002300.13320669
128RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.12427617
129Glycerolipid metabolism_Homo sapiens_hsa005610.11953304
130Base excision repair_Homo sapiens_hsa034100.09983547
131Renin-angiotensin system_Homo sapiens_hsa046140.08769438
132Thyroid hormone synthesis_Homo sapiens_hsa049180.05856614

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