IMPA2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This locus encodes an inositol monophosphatase. The encoded protein catalyzes the dephosphoylration of inositol monophosphate and plays an important role in phosphatidylinositol signaling. This locus may be associated with susceptibility to bipolar disorder. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)6.03697953
2DNA strand elongation involved in DNA replication (GO:0006271)5.45199874
3viral transcription (GO:0019083)5.34721430
4telomere maintenance via semi-conservative replication (GO:0032201)5.31774981
5translational termination (GO:0006415)5.20479759
6DNA strand elongation (GO:0022616)5.19030664
7DNA deamination (GO:0045006)5.11149686
8maturation of SSU-rRNA (GO:0030490)5.05987223
9ribosomal small subunit biogenesis (GO:0042274)4.97393461
10DNA replication initiation (GO:0006270)4.93925948
11DNA unwinding involved in DNA replication (GO:0006268)4.88503916
12translational elongation (GO:0006414)4.70821662
13telomere maintenance via recombination (GO:0000722)4.58916145
14SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.41367293
15translational initiation (GO:0006413)4.31117357
16cotranslational protein targeting to membrane (GO:0006613)4.28662016
17protein targeting to ER (GO:0045047)4.28411678
18mitotic recombination (GO:0006312)4.24899790
19nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.24663868
20DNA replication checkpoint (GO:0000076)4.21437894
21phosphatidylinositol acyl-chain remodeling (GO:0036149)4.16089316
22formation of translation preinitiation complex (GO:0001731)4.15586333
23ribosomal large subunit biogenesis (GO:0042273)4.12184298
24telomere maintenance via telomere lengthening (GO:0010833)4.09549778
25nucleobase biosynthetic process (GO:0046112)4.09166257
26establishment of protein localization to endoplasmic reticulum (GO:0072599)4.06928959
27protein localization to endoplasmic reticulum (GO:0070972)4.01988492
28cellular protein complex disassembly (GO:0043624)4.01962524
29viral life cycle (GO:0019058)3.99878185
30IMP biosynthetic process (GO:0006188)3.90410877
31ribonucleoprotein complex biogenesis (GO:0022613)3.90318998
32protein localization to kinetochore (GO:0034501)3.87542447
33nucleotide-excision repair, DNA gap filling (GO:0006297)3.87335157
34ubiquinone biosynthetic process (GO:0006744)3.85001924
35actin-myosin filament sliding (GO:0033275)3.83534132
36muscle filament sliding (GO:0030049)3.83534132
37skeletal muscle contraction (GO:0003009)3.71718118
38purine nucleobase biosynthetic process (GO:0009113)3.71031349
39IMP metabolic process (GO:0046040)3.67807524
40protein complex disassembly (GO:0043241)3.63725290
41regulation of skeletal muscle contraction (GO:0014819)3.63640545
42pseudouridine synthesis (GO:0001522)3.62388606
43establishment of skin barrier (GO:0061436)3.61998863
44keratinization (GO:0031424)3.59228349
45detection of bacterium (GO:0016045)3.54834402
46folic acid-containing compound biosynthetic process (GO:0009396)3.53371858
47ribosome biogenesis (GO:0042254)3.48632180
48quinone biosynthetic process (GO:1901663)3.46399127
49regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.45937735
50creatine metabolic process (GO:0006600)3.43821830
51macromolecular complex disassembly (GO:0032984)3.42796810
52detection of other organism (GO:0098543)3.40180394
53CENP-A containing nucleosome assembly (GO:0034080)3.38411177
54rRNA processing (GO:0006364)3.38402015
55chromatin remodeling at centromere (GO:0031055)3.37783264
56nuclear-transcribed mRNA catabolic process (GO:0000956)3.34436966
57rRNA metabolic process (GO:0016072)3.31884702
58protein localization to chromosome, centromeric region (GO:0071459)3.28656078
59ubiquinone metabolic process (GO:0006743)3.27534146
60DNA replication-dependent nucleosome organization (GO:0034723)3.25669773
61DNA replication-dependent nucleosome assembly (GO:0006335)3.25669773
62pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.25181594
63mitotic nuclear envelope disassembly (GO:0007077)3.24579488
64translation (GO:0006412)3.23395710
65negative regulation of B cell apoptotic process (GO:0002903)3.19655928
66neutrophil activation involved in immune response (GO:0002283)3.19021363
67mRNA catabolic process (GO:0006402)3.18181916
68ribosome assembly (GO:0042255)3.17872661
69RNA catabolic process (GO:0006401)3.17524309
70respiratory burst (GO:0045730)3.16291049
71regulation of nuclear cell cycle DNA replication (GO:0033262)3.10325026
72DNA duplex unwinding (GO:0032508)3.09166342
73glucan catabolic process (GO:0009251)3.09044505
74DNA replication-independent nucleosome assembly (GO:0006336)3.08998065
75DNA replication-independent nucleosome organization (GO:0034724)3.08998065
76glycogen catabolic process (GO:0005980)3.08787584
77regulation of water loss via skin (GO:0033561)3.07326271
78DNA geometric change (GO:0032392)3.07012421
79telomere maintenance (GO:0000723)3.06194943
80mitotic metaphase plate congression (GO:0007080)3.05806424
81telomere organization (GO:0032200)3.05304449
82deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.01781711
83somatic hypermutation of immunoglobulin genes (GO:0016446)3.00912638
84somatic diversification of immune receptors via somatic mutation (GO:0002566)3.00912638
85cellular polysaccharide catabolic process (GO:0044247)3.00552940
86purine nucleotide salvage (GO:0032261)2.96594016
87nuclear envelope disassembly (GO:0051081)2.95324614
88membrane disassembly (GO:0030397)2.95324614
89phosphatidylserine acyl-chain remodeling (GO:0036150)2.94296331
90transcription-coupled nucleotide-excision repair (GO:0006283)2.92797361
91modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.92568029
92positive regulation by organism of defense response of other organism involved in symbiotic interact2.92568029
93modulation by symbiont of host immune response (GO:0052553)2.92568029
94positive regulation by symbiont of host defense response (GO:0052509)2.92568029
95modulation by symbiont of host defense response (GO:0052031)2.92568029
96modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.92568029
97response to peptidoglycan (GO:0032494)2.90444130
98maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.90243682
99kinetochore organization (GO:0051383)2.89629231
100nucleotide salvage (GO:0043173)2.89555854
101cellular component biogenesis (GO:0044085)2.87743240
102actin-mediated cell contraction (GO:0070252)2.86809571
103spliceosomal snRNP assembly (GO:0000387)2.84509013
104negative regulation of RNA splicing (GO:0033119)2.81693995
105folic acid metabolic process (GO:0046655)2.81331739
106base-excision repair (GO:0006284)2.81312679
107negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.79565828
108response to interferon-beta (GO:0035456)2.78405798
109immunoglobulin mediated immune response (GO:0016064)2.78281249
110deoxyribonucleotide catabolic process (GO:0009264)2.75151381
111protein targeting to membrane (GO:0006612)2.74919892
112cell cycle G1/S phase transition (GO:0044843)2.74844817
113G1/S transition of mitotic cell cycle (GO:0000082)2.74844817
114regulation of B cell apoptotic process (GO:0002902)2.74030847
115establishment of integrated proviral latency (GO:0075713)2.73561248
116metaphase plate congression (GO:0051310)2.72206776
117mismatch repair (GO:0006298)2.72171322
118regulation of double-strand break repair via homologous recombination (GO:0010569)2.72114063
119deoxyribose phosphate catabolic process (GO:0046386)2.71384758
120pteridine-containing compound biosynthetic process (GO:0042559)2.70925058
121translesion synthesis (GO:0019985)2.69814954
1222-oxoglutarate metabolic process (GO:0006103)2.69447066
123skeletal muscle tissue regeneration (GO:0043403)2.68778897
124polysaccharide catabolic process (GO:0000272)2.68441289
125carnitine transmembrane transport (GO:1902603)2.68304513
126pyrimidine nucleoside monophosphate biosynthetic process (GO:0009130)2.67566303
127kinetochore assembly (GO:0051382)2.67419300
128phosphatidylethanolamine acyl-chain remodeling (GO:0036152)2.66255908
129nuclear pore organization (GO:0006999)2.65767553
130primary alcohol catabolic process (GO:0034310)2.65635907
131cytochrome complex assembly (GO:0017004)2.65489888
132histone exchange (GO:0043486)2.65321276
133mitotic chromosome condensation (GO:0007076)2.64585937
134meiotic chromosome segregation (GO:0045132)2.63177869
135L-fucose catabolic process (GO:0042355)2.63171746
136fucose catabolic process (GO:0019317)2.63171746
137L-fucose metabolic process (GO:0042354)2.63171746
138mitotic sister chromatid segregation (GO:0000070)2.63055450
139purine deoxyribonucleotide catabolic process (GO:0009155)2.62472770
140neutrophil mediated immunity (GO:0002446)2.62202859
141lipoxygenase pathway (GO:0019372)2.61872660
142regulation of posttranscriptional gene silencing (GO:0060147)2.61738515
143regulation of gene silencing by miRNA (GO:0060964)2.61738515
144regulation of gene silencing by RNA (GO:0060966)2.61738515
145attachment of spindle microtubules to kinetochore (GO:0008608)2.61725991
146carnitine shuttle (GO:0006853)2.61046420
147chromatin assembly or disassembly (GO:0006333)2.60726119
148sarcoplasmic reticulum calcium ion transport (GO:0070296)2.60532854
149pyrimidine nucleotide catabolic process (GO:0006244)2.59543767
150intra-S DNA damage checkpoint (GO:0031573)2.59091573
151phosphatidylcholine acyl-chain remodeling (GO:0036151)2.58735633
152carnitine transport (GO:0015879)2.58497382
153amino-acid betaine transport (GO:0015838)2.58497382
154rRNA modification (GO:0000154)2.58135330
155DNA conformation change (GO:0071103)2.57027209
156DNA replication (GO:0006260)2.55453231
157ncRNA processing (GO:0034470)2.54677123
158ncRNA 3-end processing (GO:0043628)2.54441436
159exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.53244778
160fatty acid transmembrane transport (GO:1902001)2.52256653
161regulation of mitochondrial translation (GO:0070129)2.51707874
162respiratory chain complex IV assembly (GO:0008535)2.51275506
163determination of adult lifespan (GO:0008340)2.51218775
164oxidative phosphorylation (GO:0006119)2.51154263
165cytidine deamination (GO:0009972)2.50780606
166cytidine metabolic process (GO:0046087)2.50780606
167cytidine catabolic process (GO:0006216)2.50780606
168cellular carbohydrate catabolic process (GO:0044275)2.50375943
169regulation of relaxation of muscle (GO:1901077)2.40619434
170antigen processing and presentation of endogenous antigen (GO:0019883)2.40352509
171phosphatidylglycerol acyl-chain remodeling (GO:0036148)2.39488321
172antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.37739175
173L-alpha-amino acid transmembrane transport (GO:1902475)2.37142655
174leukocyte migration involved in inflammatory response (GO:0002523)2.35589724
175pentose-phosphate shunt (GO:0006098)2.34597832
176reactive oxygen species biosynthetic process (GO:1903409)2.34390566
177protein complex biogenesis (GO:0070271)2.34110854
178pentose metabolic process (GO:0019321)2.33631624
179cellular response to interferon-beta (GO:0035458)2.33411462
180molting cycle (GO:0042303)2.32877141
181hair cycle (GO:0042633)2.32877141
182positive regulation of antigen processing and presentation (GO:0002579)2.30648613
183AMP metabolic process (GO:0046033)2.30055942
184NAD biosynthetic process (GO:0009435)2.29589650
185glycogen biosynthetic process (GO:0005978)2.29242126
186glucan biosynthetic process (GO:0009250)2.29242126
187skeletal muscle fiber development (GO:0048741)2.29128413
188mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.28582359
189mitochondrial respiratory chain complex I assembly (GO:0032981)2.28582359
190NADH dehydrogenase complex assembly (GO:0010257)2.28582359
191B cell mediated immunity (GO:0019724)2.28512592
192quaternary ammonium group transport (GO:0015697)2.28176014

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.50227740
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.18426381
3EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.87787093
4BP1_19119308_ChIP-ChIP_Hs578T_Human3.70132101
5IRF8_22096565_ChIP-ChIP_GC-B_Human3.20504411
6E2F4_17652178_ChIP-ChIP_JURKAT_Human3.18537114
7FOXM1_23109430_ChIP-Seq_U2OS_Human3.02361777
8MYC_19079543_ChIP-ChIP_MESCs_Mouse2.91349675
9MYC_18358816_ChIP-ChIP_MESCs_Mouse2.76350775
10* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.65299386
11FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.61766032
12EST1_17652178_ChIP-ChIP_JURKAT_Human2.46564590
13KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.45532400
14JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.41711857
15TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.41059450
16ETS1_20019798_ChIP-Seq_JURKAT_Human2.40690348
17GABP_17652178_ChIP-ChIP_JURKAT_Human2.35137784
18HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.22484581
19XRN2_22483619_ChIP-Seq_HELA_Human2.17010416
20CREB1_15753290_ChIP-ChIP_HEK293T_Human2.09984013
21PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.08426854
22* NELFA_20434984_ChIP-Seq_ESCs_Mouse2.06840561
23* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.05017346
24CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.03804283
25VDR_23849224_ChIP-Seq_CD4+_Human1.99126926
26MYC_22102868_ChIP-Seq_BL_Human1.98592834
27NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.97525352
28EGR1_19374776_ChIP-ChIP_THP-1_Human1.95987527
29TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.93483822
30ELF1_17652178_ChIP-ChIP_JURKAT_Human1.93021532
31E2F1_18555785_ChIP-Seq_MESCs_Mouse1.92138770
32SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.91237846
33* CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.89154544
34CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.88476417
35FOXP3_21729870_ChIP-Seq_TREG_Human1.82505226
36P68_20966046_ChIP-Seq_HELA_Human1.78513327
37E2F1_21310950_ChIP-Seq_MCF-7_Human1.76388165
38BCOR_27268052_Chip-Seq_Bcells_Human1.75961694
39* BCL6_27268052_Chip-Seq_Bcells_Human1.75423410
40NANOG_18555785_ChIP-Seq_MESCs_Mouse1.73074006
41DCP1A_22483619_ChIP-Seq_HELA_Human1.71001451
42RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.69683040
43PPARA_22158963_ChIP-Seq_LIVER_Mouse1.69573449
44LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.67909367
45VDR_21846776_ChIP-Seq_THP-1_Human1.66880462
46* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.66649212
47AR_21909140_ChIP-Seq_LNCAP_Human1.65385133
48GABP_19822575_ChIP-Seq_HepG2_Human1.65335745
49TTF2_22483619_ChIP-Seq_HELA_Human1.63976253
50POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.62580480
51E2F1_20622854_ChIP-Seq_HELA_Human1.62290919
52MYCN_18555785_ChIP-Seq_MESCs_Mouse1.59382921
53EGR1_23403033_ChIP-Seq_LIVER_Mouse1.59009903
54SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.57111345
55ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.56564204
56FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.52440446
57YY1_22570637_ChIP-Seq_MALME-3M_Human1.51653479
58THAP11_20581084_ChIP-Seq_MESCs_Mouse1.51295251
59CIITA_25753668_ChIP-Seq_RAJI_Human1.50990625
60RXR_22158963_ChIP-Seq_LIVER_Mouse1.50299461
61STAT3_1855785_ChIP-Seq_MESCs_Mouse1.50038885
62YY1_21170310_ChIP-Seq_MESCs_Mouse1.49918028
63SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.48592899
64HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.48406294
65STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.46350741
66* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.46122239
67* LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.45524970
68HOXB4_20404135_ChIP-ChIP_EML_Mouse1.45220705
69NANOG_20526341_ChIP-Seq_ESCs_Human1.42629393
70MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.41549282
71* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.40967443
72PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.40660422
73POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.40201003
74CTCF_26484167_Chip-Seq_Bcells_Mouse1.39926150
75SA1_27219007_Chip-Seq_Bcells_Human1.39485417
76ZNF263_19887448_ChIP-Seq_K562_Human1.39464726
77FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.37945611
78SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.37071310
79* P300_27268052_Chip-Seq_Bcells_Human1.35309549
80EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.35046211
81SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.30981483
82* PHF8_20622854_ChIP-Seq_HELA_Human1.30766938
83ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.30317512
84ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.30069974
85* SPI1_20517297_ChIP-Seq_HL60_Human1.29662161
86CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.29100806
87PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.29046809
88SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.28848070
89P63_26484246_Chip-Seq_KERATINOCYTES_Human1.28455040
90ELF1_20517297_ChIP-Seq_JURKAT_Human1.27971861
91RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.27868446
92SPI1_23547873_ChIP-Seq_NB4_Human1.27676090
93E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.27267428
94ELK1_19687146_ChIP-ChIP_HELA_Human1.27069430
95MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.26768007
96CTCF_21964334_ChIP-Seq_BJAB-B_Human1.26752684
97FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.26424954
98KDM5A_27292631_Chip-Seq_BREAST_Human1.25824908
99SRF_21415370_ChIP-Seq_HL-1_Mouse1.25642650
100PU.1_20513432_ChIP-Seq_Bcells_Mouse1.24185361
101SA1_27219007_Chip-Seq_ERYTHROID_Human1.24161394
102NOTCH1_21737748_ChIP-Seq_TLL_Human1.24140521
103GATA2_22383799_ChIP-Seq_G1ME_Mouse1.22676079
104RAC3_21632823_ChIP-Seq_H3396_Human1.22542276
105HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.22301487
106* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.22104241
107MYB_21317192_ChIP-Seq_ERMYB_Mouse1.18050568
108POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.17762260
109PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.16159283
110SCL_19346495_ChIP-Seq_HPC-7_Human1.16044469
111BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.16006967
112E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.15790336
113TET1_21451524_ChIP-Seq_MESCs_Mouse1.14497243
114* MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.13267500
115RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.12983430
116STAT1_20625510_ChIP-Seq_HELA_Human1.12753160
117CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.12712385
118P53_21459846_ChIP-Seq_SAOS-2_Human1.11563951
119* GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.11362657
120CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.11190779
121CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.11071090
122CTCF_21964334_Chip-Seq_Bcells_Human1.10685763
123YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.10455433
124CTCF_20526341_ChIP-Seq_ESCs_Human1.10204005
125FOXP1_21924763_ChIP-Seq_HESCs_Human1.08920956
126GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.08893241
127KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.07972416
128SMC4_20622854_ChIP-Seq_HELA_Human1.07164461
129ERA_21632823_ChIP-Seq_H3396_Human1.06573869
130IRF8_21731497_ChIP-ChIP_J774_Mouse1.06141344
131TFEB_21752829_ChIP-Seq_HELA_Human1.05230396
132P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.04651703
133KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.04312722
134VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.03940978
135MAF_26560356_Chip-Seq_TH2_Human1.03822330
136* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.03594226
137TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.03253448
138TP63_22573176_ChIP-Seq_HFKS_Human1.03245823
139E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.03187572
140* LXR_22292898_ChIP-Seq_THP-1_Human1.03112554
141* RXRA_24833708_ChIP-Seq_LIVER_Mouse1.02802346
142IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.97307799
143SOX2_18555785_ChIP-Seq_MESCs_Mouse0.95155233
144CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.94207435
145KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.93432424
146NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.92841983
147* GATA1_22383799_ChIP-Seq_G1ME_Mouse0.92418286
148BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.91714428
149TCF3_18692474_ChIP-Seq_MEFs_Mouse0.90785953
150CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.89914166
151MAF_26560356_Chip-Seq_TH1_Human0.87455145
152* RUNX1_22412390_ChIP-Seq_EML_Mouse0.86756665
153UTX_26944678_Chip-Seq_JUKART_Human0.85438452
154VDR_24763502_ChIP-Seq_THP-1_Human0.85279323
155OCT4_18692474_ChIP-Seq_MEFs_Mouse0.84728903
156ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.84211999
157TP63_19390658_ChIP-ChIP_HaCaT_Human0.83301624
158MYC_18940864_ChIP-ChIP_HL60_Human0.83295932
159* BRD4_27068464_Chip-Seq_AML-cells_Mouse0.82971643
160NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.82871607
161KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.82644333

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.56020688
2MP0010094_abnormal_chromosome_stability4.11958075
3MP0004957_abnormal_blastocyst_morpholog3.98274031
4MP0008057_abnormal_DNA_replication3.73639245
5MP0003111_abnormal_nucleus_morphology3.71728788
6MP0002396_abnormal_hematopoietic_system3.52475883
7MP0003077_abnormal_cell_cycle3.48090796
8MP0002796_impaired_skin_barrier3.23020381
9MP0008058_abnormal_DNA_repair2.86194290
10MP0004145_abnormal_muscle_electrophysio2.79558765
11MP0000490_abnormal_crypts_of2.52157293
12MP0008007_abnormal_cellular_replicative2.39522093
13MP0005451_abnormal_body_composition2.35602521
14MP0010352_gastrointestinal_tract_polyps2.32029477
15MP0004808_abnormal_hematopoietic_stem2.02191656
16MP0008932_abnormal_embryonic_tissue2.00568068
17MP0005377_hearing/vestibular/ear_phenot1.98927422
18MP0003878_abnormal_ear_physiology1.98927422
19MP0000350_abnormal_cell_proliferation1.97858446
20MP0005397_hematopoietic_system_phenotyp1.93245500
21MP0001545_abnormal_hematopoietic_system1.93245500
22MP0003806_abnormal_nucleotide_metabolis1.88734664
23MP0001730_embryonic_growth_arrest1.84302049
24MP0005501_abnormal_skin_physiology1.82878806
25MP0003763_abnormal_thymus_physiology1.77149241
26MP0003724_increased_susceptibility_to1.76110324
27MP0009333_abnormal_splenocyte_physiolog1.74660578
28MP0004381_abnormal_hair_follicle1.72471326
29MP0010307_abnormal_tumor_latency1.70745691
30MP0000383_abnormal_hair_follicle1.68895624
31MP0000749_muscle_degeneration1.68470963
32MP0002019_abnormal_tumor_incidence1.66045044
33MP0000750_abnormal_muscle_regeneration1.61242812
34MP0002398_abnormal_bone_marrow1.59525299
35MP0003786_premature_aging1.55296694
36MP0004043_abnormal_pH_regulation1.51791447
37MP0001835_abnormal_antigen_presentation1.50009275
38MP0002106_abnormal_muscle_physiology1.49839175
39MP0003123_paternal_imprinting1.49794004
40MP0000579_abnormal_nail_morphology1.49472150
41MP0002722_abnormal_immune_system1.47953904
42MP0003567_abnormal_fetal_cardiomyocyte1.46511795
43MP0008875_abnormal_xenobiotic_pharmacok1.46120553
44MP0000313_abnormal_cell_death1.45292701
45MP0000689_abnormal_spleen_morphology1.44431676
46MP0009278_abnormal_bone_marrow1.43187942
47MP0009379_abnormal_foot_pigmentation1.42706854
48MP0005174_abnormal_tail_pigmentation1.41308491
49MP0002277_abnormal_respiratory_mucosa1.41215498
50MP0006292_abnormal_olfactory_placode1.41184005
51MP0000685_abnormal_immune_system1.39524713
52MP0001697_abnormal_embryo_size1.39308716
53MP0001853_heart_inflammation1.39260197
54MP0003436_decreased_susceptibility_to1.38613339
55MP0004233_abnormal_muscle_weight1.38107312
56MP0005319_abnormal_enzyme/_coenzyme1.37305037
57MP0001672_abnormal_embryogenesis/_devel1.37089045
58MP0005380_embryogenesis_phenotype1.37089045
59MP0002080_prenatal_lethality1.36978440
60MP0000703_abnormal_thymus_morphology1.36307607
61MP0005075_abnormal_melanosome_morpholog1.36297721
62MP0003011_delayed_dark_adaptation1.33014544
63MP0004185_abnormal_adipocyte_glucose1.32458125
64MP0005332_abnormal_amino_acid1.30506609
65MP0003984_embryonic_growth_retardation1.29461292
66MP0002429_abnormal_blood_cell1.29007876
67MP0002098_abnormal_vibrissa_morphology1.28977355
68MP0004147_increased_porphyrin_level1.27709887
69MP0005083_abnormal_biliary_tract1.27381019
70MP0005330_cardiomyopathy1.26696546
71MP0000858_altered_metastatic_potential1.26082935
72MP0002088_abnormal_embryonic_growth/wei1.25658160
73MP0002086_abnormal_extraembryonic_tissu1.25136000
74MP0000465_gastrointestinal_hemorrhage1.24193959
75MP0010678_abnormal_skin_adnexa1.22616198
76MP0003186_abnormal_redox_activity1.22284803
77MP0000751_myopathy1.21865554
78MP0000747_muscle_weakness1.21780194
79MP0005365_abnormal_bile_salt1.21545560
80MP0010155_abnormal_intestine_physiology1.21458016
81MP0000716_abnormal_immune_system1.21380373
82MP0004130_abnormal_muscle_cell1.19897200
83MP0001800_abnormal_humoral_immune1.18363646
84MP0005369_muscle_phenotype1.18278590
85MP0001188_hyperpigmentation1.17867717
86MP0002420_abnormal_adaptive_immunity1.15819951
87MP0009785_altered_susceptibility_to1.14606097
88MP0001819_abnormal_immune_cell1.14436526
89MP0001873_stomach_inflammation1.14264556
90MP0006036_abnormal_mitochondrial_physio1.13713700
91MP0005025_abnormal_response_to1.13157901
92MP0004087_abnormal_muscle_fiber1.12999072
93MP0002876_abnormal_thyroid_physiology1.12677127
94MP0008877_abnormal_DNA_methylation1.12493861
95MP0002452_abnormal_antigen_presenting1.11467839
96MP0005671_abnormal_response_to1.11385929
97MP0002085_abnormal_embryonic_tissue1.10256925
98MP0002405_respiratory_system_inflammati1.09025858
99MP0000759_abnormal_skeletal_muscle1.07210375
100MP0004197_abnormal_fetal_growth/weight/1.06910247
101MP0010030_abnormal_orbit_morphology1.06777945
102MP0010234_abnormal_vibrissa_follicle1.06654402
103MP0002269_muscular_atrophy1.06270516
104MP0000470_abnormal_stomach_morphology1.03245299
105MP0003183_abnormal_peptide_metabolism1.02561865
106MP0002132_abnormal_respiratory_system1.02386017
107MP0004947_skin_inflammation1.01889917
108MP0002084_abnormal_developmental_patter1.01753532
109MP0000015_abnormal_ear_pigmentation1.01021617
110MP0004036_abnormal_muscle_relaxation0.99328407
111MP0002723_abnormal_immune_serum0.98711566
112MP0000467_abnormal_esophagus_morphology0.97630687
113MP0002166_altered_tumor_susceptibility0.97629030
114MP0005058_abnormal_lysosome_morphology0.96191310
115MP0000477_abnormal_intestine_morphology0.96115675
116MP0001216_abnormal_epidermal_layer0.95619487
117MP0000358_abnormal_cell_content/0.94778101
118MP0005464_abnormal_platelet_physiology0.93422773
119MP0003191_abnormal_cellular_cholesterol0.91498120
120MP0005000_abnormal_immune_tolerance0.91444572
121MP0003221_abnormal_cardiomyocyte_apopto0.91299675
122MP0003718_maternal_effect0.90906821
123MP0005636_abnormal_mineral_homeostasis0.90734490
124MP0003566_abnormal_cell_adhesion0.90578325
125MP0002138_abnormal_hepatobiliary_system0.90432436
126MP0005023_abnormal_wound_healing0.90266137
127MP0002254_reproductive_system_inflammat0.89866887
128MP0005266_abnormal_metabolism0.88054980
129MP0008469_abnormal_protein_level0.87770528
130MP0009643_abnormal_urine_homeostasis0.86451505
131MP0003866_abnormal_defecation0.86344179
132MP0002006_tumorigenesis0.86264997
133MP0002095_abnormal_skin_pigmentation0.85198660
134MP0003638_abnormal_response/metabolism_0.85074745
135MP0002837_dystrophic_cardiac_calcinosis0.84327346
136MP0009931_abnormal_skin_appearance0.84303632
137MP0002419_abnormal_innate_immunity0.83970996
138MP0001661_extended_life_span0.82966473
139MP0009764_decreased_sensitivity_to0.82569364
140MP0002210_abnormal_sex_determination0.82512187
141MP0001666_abnormal_nutrient_absorption0.82310319
142MP0001145_abnormal_male_reproductive0.81560098
143MP0003646_muscle_fatigue0.81282490
144MP0005076_abnormal_cell_differentiation0.81156834
145MP0010771_integument_phenotype0.80621456
146MP0001293_anophthalmia0.79409019
147MP0000343_altered_response_to0.78089908
148MP0005387_immune_system_phenotype0.77711503
149MP0001790_abnormal_immune_system0.77711503
150MP0005084_abnormal_gallbladder_morpholo0.77231372
151MP0000377_abnormal_hair_follicle0.77205384
152MP0001764_abnormal_homeostasis0.75126041
153MP0002148_abnormal_hypersensitivity_rea0.74388129
154MP0002653_abnormal_ependyma_morphology0.73911923
155MP0003315_abnormal_perineum_morphology0.72980799
156MP0001845_abnormal_inflammatory_respons0.71442762
157MP0001986_abnormal_taste_sensitivity0.69801172
158MP0003448_altered_tumor_morphology0.69076924
159MP0005384_cellular_phenotype0.68805375
160MP0004264_abnormal_extraembryonic_tissu0.67556872
161MP0005621_abnormal_cell_physiology0.65965882
162MP0006035_abnormal_mitochondrial_morpho0.65765244
163MP0003303_peritoneal_inflammation0.64050322
164MP0004133_heterotaxia0.61958620
165MP0000653_abnormal_sex_gland0.61502363
166MP0002075_abnormal_coat/hair_pigmentati0.60119249

Predicted human phenotypes

RankGene SetZ-score
1Nemaline bodies (HP:0003798)6.22614799
2Muscle fiber inclusion bodies (HP:0100299)6.21521028
3Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)5.86294048
4Abnormality of cells of the erythroid lineage (HP:0012130)5.62114880
5Reticulocytopenia (HP:0001896)5.52811363
6Abnormal number of erythroid precursors (HP:0012131)5.36149172
7Exercise-induced myalgia (HP:0003738)4.97991852
8Birth length less than 3rd percentile (HP:0003561)4.30881388
9Myopathic facies (HP:0002058)4.18595976
10Thrombocytosis (HP:0001894)4.07392809
11Increased IgE level (HP:0003212)3.93464685
12Exercise-induced muscle cramps (HP:0003710)3.88907827
13Rhabdomyolysis (HP:0003201)3.88036002
14Aplastic anemia (HP:0001915)3.84864450
15Colon cancer (HP:0003003)3.67701632
16Macrocytic anemia (HP:0001972)3.60567466
17Oral leukoplakia (HP:0002745)3.53205244
18Pallor (HP:0000980)3.49553746
19Type 1 muscle fiber predominance (HP:0003803)3.34440698
20Eczematoid dermatitis (HP:0000976)3.29770715
21Myoglobinuria (HP:0002913)3.29546067
22Muscle hypertrophy of the lower extremities (HP:0008968)3.20716449
23Muscle stiffness (HP:0003552)3.11468320
24Breast hypoplasia (HP:0003187)3.10306565
25Chromsome breakage (HP:0040012)3.10141769
26Distal arthrogryposis (HP:0005684)3.09616570
27Ependymoma (HP:0002888)3.07283135
28IgM deficiency (HP:0002850)3.05768407
29Selective tooth agenesis (HP:0001592)2.98682900
30Multiple enchondromatosis (HP:0005701)2.95540493
31Agnosia (HP:0010524)2.86285105
32Stomatitis (HP:0010280)2.79388480
33Rough bone trabeculation (HP:0100670)2.77207885
34Increased muscle lipid content (HP:0009058)2.76078941
35Microretrognathia (HP:0000308)2.74860131
36Chromosomal breakage induced by crosslinking agents (HP:0003221)2.73174858
37Absent thumb (HP:0009777)2.73055527
38EMG: myopathic abnormalities (HP:0003458)2.72437391
39Myelodysplasia (HP:0002863)2.69629538
40Areflexia of lower limbs (HP:0002522)2.67039812
4111 pairs of ribs (HP:0000878)2.65672747
42Type I transferrin isoform profile (HP:0003642)2.63797701
43Elevated erythrocyte sedimentation rate (HP:0003565)2.61685219
44Abnormality of the preputium (HP:0100587)2.56356531
45Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.54076758
46Decreased activity of mitochondrial respiratory chain (HP:0008972)2.54076758
47Recurrent bacterial skin infections (HP:0005406)2.53056618
48Aplasia/Hypoplasia of the sacrum (HP:0008517)2.52380516
49Basal cell carcinoma (HP:0002671)2.49114953
50Centrally nucleated skeletal muscle fibers (HP:0003687)2.48753912
51Abnormality of chromosome stability (HP:0003220)2.48013291
52Recurrent abscess formation (HP:0002722)2.47707742
53Paralysis (HP:0003470)2.45819917
54Medulloblastoma (HP:0002885)2.45814217
55Rimmed vacuoles (HP:0003805)2.45648015
56Hepatocellular necrosis (HP:0001404)2.44772629
57Calf muscle hypertrophy (HP:0008981)2.43703785
58Hyperglycinuria (HP:0003108)2.43527369
59Abnormality of T cell physiology (HP:0011840)2.41587775
60Muscle fiber splitting (HP:0003555)2.41029776
61Poikiloderma (HP:0001029)2.39842713
62Ulnar deviation of the wrist (HP:0003049)2.39596726
63Premature graying of hair (HP:0002216)2.34798561
64Reduced antithrombin III activity (HP:0001976)2.34627592
65Bone marrow hypocellularity (HP:0005528)2.33965051
66Pancytopenia (HP:0001876)2.33596819
67Hypomagnesemia (HP:0002917)2.29737650
68Meckel diverticulum (HP:0002245)2.28432948
69Carpal bone hypoplasia (HP:0001498)2.28037500
70Patellar aplasia (HP:0006443)2.26958782
71Hepatic necrosis (HP:0002605)2.26771559
72Urticaria (HP:0001025)2.24645203
73Amaurosis fugax (HP:0100576)2.24422011
74Petechiae (HP:0000967)2.23710525
75Abnormality of the anterior horn cell (HP:0006802)2.23172446
76Degeneration of anterior horn cells (HP:0002398)2.23172446
77Conjunctival hamartoma (HP:0100780)2.23167651
78Abnormality of the ileum (HP:0001549)2.22416861
79Distal lower limb muscle weakness (HP:0009053)2.21564839
80Rhabdomyosarcoma (HP:0002859)2.21165738
81Round ear (HP:0100830)2.20427099
82Palmoplantar hyperkeratosis (HP:0000972)2.19710955
83Neoplasm of the pancreas (HP:0002894)2.19113424
84Trismus (HP:0000211)2.19091175
85Erythroderma (HP:0001019)2.17964051
86Lymphoma (HP:0002665)2.17268042
87Ragged-red muscle fibers (HP:0003200)2.13831642
88Progressive muscle weakness (HP:0003323)2.12892233
89Neck muscle weakness (HP:0000467)2.11052063
90Abnormality of magnesium homeostasis (HP:0004921)2.10474045
91Aplasia/Hypoplasia of the uvula (HP:0010293)2.09517470
92Malignant hyperthermia (HP:0002047)2.08520489
93Aplasia/Hypoplasia of the patella (HP:0006498)2.07943592
94Exercise intolerance (HP:0003546)2.07676176
95Ventricular tachycardia (HP:0004756)2.07355879
96Mitochondrial inheritance (HP:0001427)2.07271735
97Hyporeflexia of lower limbs (HP:0002600)2.07188758
98Asplenia (HP:0001746)2.07086713
99Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.05690566
100Abnormality of reticulocytes (HP:0004312)2.05589004
101Type 2 muscle fiber atrophy (HP:0003554)2.05011051
102Tracheoesophageal fistula (HP:0002575)2.04932749
103Dicarboxylic aciduria (HP:0003215)2.04833863
104Abnormality of dicarboxylic acid metabolism (HP:0010995)2.04833863
105Abnormal mitochondria in muscle tissue (HP:0008316)2.03067947
106Recurrent fungal infections (HP:0002841)2.02636711
107Cerebral hypomyelination (HP:0006808)2.01873368
108Chronic otitis media (HP:0000389)2.01066456
109Orchitis (HP:0100796)2.00844293
110Congenital ichthyosiform erythroderma (HP:0007431)2.00323329
111Abnormal glycosylation (HP:0012345)2.00003244
112Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.00003244
113Abnormal protein N-linked glycosylation (HP:0012347)2.00003244
114Abnormal protein glycosylation (HP:0012346)2.00003244
115Obstructive lung disease (HP:0006536)1.99965610
116Chronic obstructive pulmonary disease (HP:0006510)1.99965610
117Acute necrotizing encephalopathy (HP:0006965)1.99644170
118Cellular immunodeficiency (HP:0005374)1.98926652
119Palmar hyperkeratosis (HP:0010765)1.98787438
120Abnormality of T cells (HP:0002843)1.98272685
121Generalized muscle weakness (HP:0003324)1.97303940
122Exertional dyspnea (HP:0002875)1.97228987
123Tetany (HP:0001281)1.96911416
124Lactic acidosis (HP:0003128)1.94613725
125Increased CSF lactate (HP:0002490)1.92797709
126Recurrent skin infections (HP:0001581)1.91960886
127Sparse eyelashes (HP:0000653)1.91188578
128Lipid accumulation in hepatocytes (HP:0006561)1.90465271
129Cerebral palsy (HP:0100021)1.90442979
130Missing ribs (HP:0000921)1.90431346
131Squamous cell carcinoma (HP:0002860)1.89742113
132Amelogenesis imperfecta (HP:0000705)1.89498287
133Chest pain (HP:0100749)1.89099810
134Abnormality of glycine metabolism (HP:0010895)1.88387623
135Abnormality of serine family amino acid metabolism (HP:0010894)1.88387623
136Alkalosis (HP:0001948)1.88328545
137Increased serum ferritin (HP:0003281)1.87871576
138Abnormality of the heme biosynthetic pathway (HP:0010472)1.87753175
139Slender long bone (HP:0003100)1.87380218
140Plantar hyperkeratosis (HP:0007556)1.86392684
141Hyperammonemia (HP:0001987)1.86137209
142Abnormality of nail color (HP:0100643)1.85400870
143Calcaneovalgus deformity (HP:0001848)1.85382779
144Acute lymphatic leukemia (HP:0006721)1.85285737
145Absent rod-and cone-mediated responses on ERG (HP:0007688)1.85093679
146Aplasia/Hypoplasia of the spleen (HP:0010451)1.84984530
147Premature ovarian failure (HP:0008209)1.84148621
148Panhypogammaglobulinemia (HP:0003139)1.83508588
149Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.83368176
150Abnormality of alanine metabolism (HP:0010916)1.83368176
151Hyperalaninemia (HP:0003348)1.83368176
152Abnormality of skeletal muscle fiber size (HP:0012084)1.83205781
153Myositis (HP:0100614)1.82853250
154Abnormal trabecular bone morphology (HP:0100671)1.82750927
155Abnormality of the left ventricular outflow tract (HP:0011103)1.82568564
156Subaortic stenosis (HP:0001682)1.82568564
157Abnormality of DNA repair (HP:0003254)1.82202826
158Acute encephalopathy (HP:0006846)1.81689912
159Neoplasm of the colon (HP:0100273)1.80099543
160Hypochromic anemia (HP:0001931)1.79643627
161Muscle fiber atrophy (HP:0100295)1.79596683
162Hypochromic microcytic anemia (HP:0004840)1.78853906
163Increased serum lactate (HP:0002151)1.78833799
164Abnormality of transition element cation homeostasis (HP:0011030)1.78697269
165Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.78606270
166Prominent nose (HP:0000448)1.78401035
167Decreased electroretinogram (ERG) amplitude (HP:0000654)1.78384392
168Chronic mucocutaneous candidiasis (HP:0002728)1.77892830
169Recurrent cutaneous fungal infections (HP:0011370)1.77892830
170Small intestinal stenosis (HP:0012848)1.77664533
171Duodenal stenosis (HP:0100867)1.77664533
172Abnormality of pyrimidine metabolism (HP:0004353)1.77550435
173Abnormal number of incisors (HP:0011064)1.76911779
174Sloping forehead (HP:0000340)1.76409894
175Clubbing of toes (HP:0100760)1.76333892
176Recurrent viral infections (HP:0004429)1.75498596
177Neoplasm of the oral cavity (HP:0100649)1.75302871
178Pulmonary fibrosis (HP:0002206)1.72755769
179Increased intramyocellular lipid droplets (HP:0012240)1.70442025
180Impulsivity (HP:0100710)1.70329623
181Proximal placement of thumb (HP:0009623)1.69713527
182Absent radius (HP:0003974)1.69170617
183Acute myeloid leukemia (HP:0004808)1.68847155
184Microvesicular hepatic steatosis (HP:0001414)1.66082357
185Triphalangeal thumb (HP:0001199)1.64953461
186Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.64045297
187Angiofibromas (HP:0010615)1.64021437
188Adenoma sebaceum (HP:0009720)1.64021437

Predicted kinase interactions (KEA)

RankGene SetZ-score
1OBSCN5.08674037
2WEE14.32412008
3CDC73.53770875
4BUB13.33928099
5NME23.17306483
6PHKG12.69512964
7PHKG22.69512964
8VRK22.55602007
9STK162.38207912
10NEK22.34482929
11EIF2AK12.30500719
12TTN2.22089787
13RPS6KB22.21402132
14EIF2AK32.21103982
15EEF2K2.17711195
16ZAK2.13738873
17ACVR1B2.05661126
18PINK11.99929883
19BRSK21.99444701
20CDK71.85955945
21FLT31.85843971
22PIK3CG1.84264664
23NEK11.78171434
24SCYL21.76547449
25TESK21.76255792
26PIM21.73554702
27MAP4K11.72393023
28TGFBR11.61934307
29VRK11.61291369
30OXSR11.58549911
31TAOK31.58082242
32TLK11.57488143
33TTK1.57175000
34PLK11.56740678
35PKN21.53941123
36PASK1.52786712
37MAP2K61.50114768
38PDK21.49654952
39DYRK31.47947786
40MAP3K71.42077116
41ATR1.41450163
42SMG11.41224669
43CDK41.39613391
44AURKB1.37767355
45RPS6KA41.37623279
46TSSK61.36366931
47TEC1.36178838
48SRPK11.33199083
49MUSK1.31299953
50TBK11.27726048
51STK101.25695744
52BTK1.23547920
53MAPKAPK31.23441787
54KIT1.19446760
55TNK21.18213877
56MAP3K11.16327691
57MAP2K31.15853030
58MAP3K31.15194353
59MAP3K81.14943432
60MKNK11.14851625
61MAP2K21.12947228
62BCKDK1.12818245
63KDR1.12644398
64PAK41.12236448
65MAP2K41.10996896
66PIM11.10698119
67PLK41.09323782
68CDK121.08848042
69NUAK11.08719864
70LRRK21.05118652
71WNK31.02734681
72FES1.00961986
73PBK0.99696359
74CDK80.99239688
75TAOK10.98959584
76CHEK20.98646512
77MAP3K100.98373234
78STK40.97559887
79CSF1R0.95081247
80BRSK10.93943090
81AURKA0.92724193
82ZAP700.91414500
83CCNB10.87311093
84IRAK10.86819646
85MST1R0.86330232
86MAPK120.85189148
87MAP3K110.82663939
88BLK0.81812241
89GRK60.80646429
90MATK0.80115344
91MKNK20.79978937
92CHEK10.79853812
93IKBKE0.77334606
94PRKAA20.73189771
95JAK30.72819629
96MAP3K130.71893739
97IRAK40.68543771
98PAK10.66193084
99ADRBK20.65091235
100ERN10.65007144
101PTK60.63352960
102CSNK2A20.62763153
103CLK10.62311590
104FRK0.62209535
105EPHA20.62055155
106TYK20.60225764
107CDK190.60040118
108CDK20.59605826
109BMPR1B0.58186771
110HCK0.57925134
111TXK0.57348667
112WNK40.56326203
113RPS6KA10.56268739
114ATM0.56098312
115CSNK2A10.56097871
116IRAK20.55479110
117GRK10.55290695
118MAP4K20.54219493
119EIF2AK20.54167846
120PIK3CA0.54062933
121CSK0.53407982
122RIPK40.52462377
123ILK0.51982451
124STK240.50928723
125CDK60.50365820
126NLK0.50187571
127ALK0.50069926
128RAF10.48937226
129TGFBR20.48651025
130ABL20.48010707
131PRKG20.47625165
132SYK0.47059132
133STK110.44061379
134MAPK110.44007590
135RPS6KC10.43946514
136RPS6KL10.43946514
137PLK30.43286493
138PDPK10.43011936
139RPS6KA60.42752701
140DYRK20.42124302
141MAP3K60.41815209
142ADRBK10.40003014
143CAMKK20.39928690
144LCK0.39892160
145PRKCI0.38977028
146AKT20.37970288
147LYN0.36642558
148DAPK10.36639311
149TRIB30.35024512
150MAPK40.34914350
151NME10.34453640
152IKBKB0.31672875
153TESK10.31457448

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030305.69343161
2Mismatch repair_Homo sapiens_hsa034304.59333999
3Ribosome_Homo sapiens_hsa030104.49285187
4Base excision repair_Homo sapiens_hsa034103.28875307
5Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.05728990
6Homologous recombination_Homo sapiens_hsa034403.01043482
7Nucleotide excision repair_Homo sapiens_hsa034202.86655362
8Spliceosome_Homo sapiens_hsa030402.86402637
9RNA polymerase_Homo sapiens_hsa030202.69052568
10alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.63780585
11Proteasome_Homo sapiens_hsa030502.61903107
12One carbon pool by folate_Homo sapiens_hsa006702.47116128
13RNA transport_Homo sapiens_hsa030132.45693147
14Pyrimidine metabolism_Homo sapiens_hsa002402.43679559
15Linoleic acid metabolism_Homo sapiens_hsa005912.24887173
16Cell cycle_Homo sapiens_hsa041102.21141563
17Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.02590641
18Non-homologous end-joining_Homo sapiens_hsa034501.97617495
19Fanconi anemia pathway_Homo sapiens_hsa034601.91896399
20Fatty acid elongation_Homo sapiens_hsa000621.82410062
21Fatty acid degradation_Homo sapiens_hsa000711.74589468
22Fat digestion and absorption_Homo sapiens_hsa049751.72811998
23Ether lipid metabolism_Homo sapiens_hsa005651.58701246
24Nitrogen metabolism_Homo sapiens_hsa009101.56503821
25RNA degradation_Homo sapiens_hsa030181.55827513
26Staphylococcus aureus infection_Homo sapiens_hsa051501.44764833
27Asthma_Homo sapiens_hsa053101.43628318
28Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.40167364
29Pentose and glucuronate interconversions_Homo sapiens_hsa000401.39137401
30p53 signaling pathway_Homo sapiens_hsa041151.35230600
31Starch and sucrose metabolism_Homo sapiens_hsa005001.34856668
32Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.34619496
33Vitamin digestion and absorption_Homo sapiens_hsa049771.33350924
34Basal transcription factors_Homo sapiens_hsa030221.33169561
35Histidine metabolism_Homo sapiens_hsa003401.31102588
36Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.31071359
37Pentose phosphate pathway_Homo sapiens_hsa000301.30606182
38Folate biosynthesis_Homo sapiens_hsa007901.27831959
39Tryptophan metabolism_Homo sapiens_hsa003801.20955721
40Purine metabolism_Homo sapiens_hsa002301.19630603
41Glycerophospholipid metabolism_Homo sapiens_hsa005641.13244210
42Autoimmune thyroid disease_Homo sapiens_hsa053201.11755211
43Sulfur metabolism_Homo sapiens_hsa009201.10974052
44Allograft rejection_Homo sapiens_hsa053301.10688573
45Alzheimers disease_Homo sapiens_hsa050101.09482262
46Phenylalanine metabolism_Homo sapiens_hsa003601.08580707
47Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.07577820
48Biosynthesis of amino acids_Homo sapiens_hsa012301.07265629
49mRNA surveillance pathway_Homo sapiens_hsa030151.06517574
50Primary immunodeficiency_Homo sapiens_hsa053401.06006358
51Arginine biosynthesis_Homo sapiens_hsa002201.05946414
52Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.05079728
53beta-Alanine metabolism_Homo sapiens_hsa004101.01574033
54Herpes simplex infection_Homo sapiens_hsa051681.01267810
55Antigen processing and presentation_Homo sapiens_hsa046121.00805757
56Butanoate metabolism_Homo sapiens_hsa006501.00223962
57Cardiac muscle contraction_Homo sapiens_hsa042601.00187543
58Glycerolipid metabolism_Homo sapiens_hsa005610.99752996
59Pancreatic secretion_Homo sapiens_hsa049720.99688977
60Peroxisome_Homo sapiens_hsa041460.99319817
61Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.96990016
62Pyruvate metabolism_Homo sapiens_hsa006200.96303639
63Arginine and proline metabolism_Homo sapiens_hsa003300.95574619
64Cyanoamino acid metabolism_Homo sapiens_hsa004600.95444525
65Drug metabolism - other enzymes_Homo sapiens_hsa009830.94442089
66Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.94372114
67Graft-versus-host disease_Homo sapiens_hsa053320.93116988
68Sulfur relay system_Homo sapiens_hsa041220.92573369
69Epstein-Barr virus infection_Homo sapiens_hsa051690.91938969
70Chemical carcinogenesis_Homo sapiens_hsa052040.91474701
71Fatty acid metabolism_Homo sapiens_hsa012120.91385463
72Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.90804653
732-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.87460206
74Systemic lupus erythematosus_Homo sapiens_hsa053220.86093599
75Regulation of autophagy_Homo sapiens_hsa041400.85695514
76Carbon metabolism_Homo sapiens_hsa012000.83771567
77Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.81276487
78Cysteine and methionine metabolism_Homo sapiens_hsa002700.81184053
79Tyrosine metabolism_Homo sapiens_hsa003500.80695892
80Retinol metabolism_Homo sapiens_hsa008300.79948125
81Thyroid cancer_Homo sapiens_hsa052160.77625449
82Galactose metabolism_Homo sapiens_hsa000520.77556153
83Propanoate metabolism_Homo sapiens_hsa006400.76257280
84Type I diabetes mellitus_Homo sapiens_hsa049400.74625732
85Legionellosis_Homo sapiens_hsa051340.71738970
86Steroid hormone biosynthesis_Homo sapiens_hsa001400.69776636
87Fructose and mannose metabolism_Homo sapiens_hsa000510.69433521
88Viral carcinogenesis_Homo sapiens_hsa052030.67761234
89Maturity onset diabetes of the young_Homo sapiens_hsa049500.67233889
90Glutathione metabolism_Homo sapiens_hsa004800.65575861
91N-Glycan biosynthesis_Homo sapiens_hsa005100.62601371
92Transcriptional misregulation in cancer_Homo sapiens_hsa052020.62179501
93Ovarian steroidogenesis_Homo sapiens_hsa049130.61996301
94Huntingtons disease_Homo sapiens_hsa050160.61090012
95HTLV-I infection_Homo sapiens_hsa051660.59888735
96Parkinsons disease_Homo sapiens_hsa050120.58940217
97Phototransduction_Homo sapiens_hsa047440.58584924
98Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.56754186
99Glucagon signaling pathway_Homo sapiens_hsa049220.56386505
100Other glycan degradation_Homo sapiens_hsa005110.54841580
101Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.54569951
102Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.53207626
103Selenocompound metabolism_Homo sapiens_hsa004500.52734770
104Tuberculosis_Homo sapiens_hsa051520.50851176
105Acute myeloid leukemia_Homo sapiens_hsa052210.50672659
106Measles_Homo sapiens_hsa051620.50209609
107Protein export_Homo sapiens_hsa030600.49800039
108Apoptosis_Homo sapiens_hsa042100.49003530
109Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.48660226
110Small cell lung cancer_Homo sapiens_hsa052220.46745214
111Shigellosis_Homo sapiens_hsa051310.45419741
112Viral myocarditis_Homo sapiens_hsa054160.45133873
113Insulin resistance_Homo sapiens_hsa049310.42888623
114Leishmaniasis_Homo sapiens_hsa051400.42856030
115Hematopoietic cell lineage_Homo sapiens_hsa046400.42764505
116RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.42576960
117Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.41227992
118NF-kappa B signaling pathway_Homo sapiens_hsa040640.40533724
119Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.39773854
120Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.38529580
121Oocyte meiosis_Homo sapiens_hsa041140.36780694
122Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.36536336
123Intestinal immune network for IgA production_Homo sapiens_hsa046720.36507684
124Hepatitis B_Homo sapiens_hsa051610.35495118
125Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.35428625
126Central carbon metabolism in cancer_Homo sapiens_hsa052300.34709608
127Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.31962826
128HIF-1 signaling pathway_Homo sapiens_hsa040660.31402492
129NOD-like receptor signaling pathway_Homo sapiens_hsa046210.30664788
130Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.28569058
131Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.28420520
132Oxidative phosphorylation_Homo sapiens_hsa001900.27804876
133Influenza A_Homo sapiens_hsa051640.27721355
134B cell receptor signaling pathway_Homo sapiens_hsa046620.27082885
135Colorectal cancer_Homo sapiens_hsa052100.25917685
136* Metabolic pathways_Homo sapiens_hsa011000.25743013
137Chronic myeloid leukemia_Homo sapiens_hsa052200.24557044
138Renin-angiotensin system_Homo sapiens_hsa046140.24196783
139Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.24097058
140Jak-STAT signaling pathway_Homo sapiens_hsa046300.22771719
141Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.22313547
142MicroRNAs in cancer_Homo sapiens_hsa052060.22078591
143Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.21303845
144Notch signaling pathway_Homo sapiens_hsa043300.21298296
145Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.19283660
146Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.18739130
147Leukocyte transendothelial migration_Homo sapiens_hsa046700.18330696
148Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.18104590
149Arachidonic acid metabolism_Homo sapiens_hsa005900.17704735
150Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.17445303
151Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.16758342
152Bladder cancer_Homo sapiens_hsa052190.14543948

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