IMPACT

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)5.64698495
2neuron cell-cell adhesion (GO:0007158)5.37791459
3negative regulation of synaptic transmission, GABAergic (GO:0032229)5.34963331
4presynaptic membrane assembly (GO:0097105)5.34896296
5vocalization behavior (GO:0071625)5.33081937
6transferrin transport (GO:0033572)5.08076217
7synaptic vesicle exocytosis (GO:0016079)5.07147252
8neurotransmitter-gated ion channel clustering (GO:0072578)4.89030652
9presynaptic membrane organization (GO:0097090)4.88119543
10energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)4.87376519
11ATP hydrolysis coupled proton transport (GO:0015991)4.87376519
12ferric iron transport (GO:0015682)4.74791653
13trivalent inorganic cation transport (GO:0072512)4.74791653
14regulation of short-term neuronal synaptic plasticity (GO:0048172)4.73139434
15regulation of synaptic vesicle exocytosis (GO:2000300)4.63846274
16synaptic vesicle docking involved in exocytosis (GO:0016081)4.54139547
17glutamate secretion (GO:0014047)4.42870419
18regulation of glutamate receptor signaling pathway (GO:1900449)4.41766253
19startle response (GO:0001964)4.38797236
20neurotransmitter secretion (GO:0007269)4.35384033
21regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.32024194
22postsynaptic membrane organization (GO:0001941)4.29154374
23negative regulation of dendrite morphogenesis (GO:0050774)4.24886445
24neuron-neuron synaptic transmission (GO:0007270)4.20674737
25regulation of meiosis I (GO:0060631)4.10021085
26gamma-aminobutyric acid signaling pathway (GO:0007214)4.08570774
27succinate metabolic process (GO:0006105)4.04809283
28neuronal action potential propagation (GO:0019227)4.04587652
29regulation of synaptic vesicle transport (GO:1902803)4.01594449
30establishment of integrated proviral latency (GO:0075713)4.00649186
31phagosome maturation (GO:0090382)3.97740441
32long-term synaptic potentiation (GO:0060291)3.89091400
33regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.82827044
34positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.82822521
35membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.80585759
36gamma-aminobutyric acid transport (GO:0015812)3.79293037
37response to histamine (GO:0034776)3.78632206
38protein localization to synapse (GO:0035418)3.77819028
39negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.77338458
40female mating behavior (GO:0060180)3.76884504
41L-serine metabolic process (GO:0006563)3.74992126
42synaptic transmission, glutamatergic (GO:0035249)3.74278624
43somatic diversification of immune receptors via somatic mutation (GO:0002566)3.72586788
44somatic hypermutation of immunoglobulin genes (GO:0016446)3.72586788
45positive regulation of synapse assembly (GO:0051965)3.68501628
46regulation of synaptic transmission, GABAergic (GO:0032228)3.67850368
47chromatin remodeling at centromere (GO:0031055)3.66023668
48ionotropic glutamate receptor signaling pathway (GO:0035235)3.58636575
49lysine metabolic process (GO:0006553)3.55488026
50lysine catabolic process (GO:0006554)3.55488026
51CENP-A containing nucleosome assembly (GO:0034080)3.53611300
52regulation of female receptivity (GO:0045924)3.53579371
53neurotransmitter transport (GO:0006836)3.52398002
54ribosome assembly (GO:0042255)3.49388657
55nuclear pore organization (GO:0006999)3.48460195
56regulation of penile erection (GO:0060405)3.47315781
57nuclear pore complex assembly (GO:0051292)3.45079561
58mitotic sister chromatid cohesion (GO:0007064)3.44344671
59striatum development (GO:0021756)3.43974724
60regulation of synaptic transmission, glutamatergic (GO:0051966)3.42551594
61positive regulation of synaptic transmission, GABAergic (GO:0032230)3.39295810
62regulation of glutamate secretion (GO:0014048)3.37971687
63NADH metabolic process (GO:0006734)3.36585325
64synapsis (GO:0007129)3.36037591
65positive regulation of amino acid transport (GO:0051957)3.35142040
66regulation of dopamine uptake involved in synaptic transmission (GO:0051584)3.34801746
67regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)3.34801746
68branched-chain amino acid catabolic process (GO:0009083)3.33260506
69glutamate receptor signaling pathway (GO:0007215)3.32755609
70regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.32050154
71positive regulation of action potential (GO:0045760)3.31400031
72cellular response to ammonium ion (GO:0071242)3.31128418
73positive regulation of mitochondrial fission (GO:0090141)3.30435486
74regulation of neurotransmitter levels (GO:0001505)3.27190411
75protein localization to cilium (GO:0061512)3.26912090
76aggressive behavior (GO:0002118)3.26737814
77negative regulation of meiosis (GO:0045835)3.26286326
78negative regulation of neurotransmitter transport (GO:0051589)3.23983411
79mitotic metaphase plate congression (GO:0007080)3.21820972
80negative regulation of dendrite development (GO:2000171)3.21516170
81cerebellar granule cell differentiation (GO:0021707)3.19489484
82regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.18389499
83regulation of mitotic spindle checkpoint (GO:1903504)3.18389499
84locomotory exploration behavior (GO:0035641)3.18351459
85response to cocaine (GO:0042220)3.16527230
86positive regulation of neurotransmitter transport (GO:0051590)3.16375741
87positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.15718254
88paraxial mesoderm development (GO:0048339)3.14756845
89inositol phosphate catabolic process (GO:0071545)3.13668146
90metaphase plate congression (GO:0051310)3.12496428
91neurotransmitter uptake (GO:0001504)3.06451746
92synaptic vesicle maturation (GO:0016188)3.06268522
93regulation of neurotransmitter secretion (GO:0046928)3.05854883
94protein-cofactor linkage (GO:0018065)3.05825440
95positive regulation of synapse maturation (GO:0090129)3.05536744
96response to X-ray (GO:0010165)3.05033510
97intraciliary transport (GO:0042073)3.04964492
98positive regulation of synaptic transmission (GO:0050806)3.04916425
99regulation of action potential (GO:0098900)3.04908139
100regulation of excitatory postsynaptic membrane potential (GO:0060079)3.04832588
101regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)3.04473845
102synaptic vesicle endocytosis (GO:0048488)3.04455503
103proline transport (GO:0015824)3.04256462
104serotonin receptor signaling pathway (GO:0007210)3.03009416
105regulation of neurotransmitter transport (GO:0051588)3.02668652
106histone exchange (GO:0043486)3.02043047
107cullin deneddylation (GO:0010388)3.01591836
108regulation of synapse maturation (GO:0090128)2.98770482
109regulation of neurotransmitter uptake (GO:0051580)2.98131970
110double-strand break repair via nonhomologous end joining (GO:0006303)2.97779939
111non-recombinational repair (GO:0000726)2.97779939
112opioid receptor signaling pathway (GO:0038003)2.97619314
113DNA ligation (GO:0006266)2.97071006
114synaptic transmission, dopaminergic (GO:0001963)2.96525754
115regulation of protein kinase A signaling (GO:0010738)2.96488453
116synaptic transmission (GO:0007268)2.95500070
117mechanosensory behavior (GO:0007638)2.95352632
118oxaloacetate metabolic process (GO:0006107)2.95072530
119lactate metabolic process (GO:0006089)2.93530852
120DNA double-strand break processing (GO:0000729)2.92645595
121iron ion transport (GO:0006826)2.91335365
122negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.91328194
123negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.91328194
124negative regulation of mitotic sister chromatid segregation (GO:0033048)2.91328194
125negative regulation of mitotic sister chromatid separation (GO:2000816)2.91328194
126negative regulation of sister chromatid segregation (GO:0033046)2.91328194
127regulation of amino acid transport (GO:0051955)2.90999801
128regulation of long-term neuronal synaptic plasticity (GO:0048169)2.90394721
129regulation of postsynaptic membrane potential (GO:0060078)2.90335271
130protein deneddylation (GO:0000338)2.89374556
131regulation of helicase activity (GO:0051095)2.88559528
132regulation of mitotic metaphase/anaphase transition (GO:0030071)2.88150626
133regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.88150626
134cell fate commitment involved in formation of primary germ layer (GO:0060795)2.87039472
135regulation of synapse assembly (GO:0051963)2.86733055
136positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.86579176
137negative regulation of synaptic transmission (GO:0050805)2.86386566
138behavioral fear response (GO:0001662)2.84685452
139behavioral defense response (GO:0002209)2.84685452
140negative regulation of DNA-dependent DNA replication (GO:2000104)2.84118515
141somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.83893906
142isotype switching (GO:0045190)2.83893906
143somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.83893906
144cerebellar Purkinje cell differentiation (GO:0021702)2.83878953
145negative regulation of chromosome segregation (GO:0051985)2.83521595
146proteasome assembly (GO:0043248)2.82540672
147regulation of DNA endoreduplication (GO:0032875)2.80765222
148protein localization to kinetochore (GO:0034501)2.80630524
149mitotic spindle checkpoint (GO:0071174)2.80025168
150regulation of cofactor metabolic process (GO:0051193)2.78032843
151regulation of coenzyme metabolic process (GO:0051196)2.78032843
152DNA damage response, detection of DNA damage (GO:0042769)2.76573842
153negative regulation of DNA recombination (GO:0045910)2.76467450
154spindle checkpoint (GO:0031577)2.75900399
155establishment of viral latency (GO:0019043)2.73403824
156regulation of mitotic sister chromatid segregation (GO:0033047)2.71055398
157regulation of sister chromatid segregation (GO:0033045)2.71055398
158regulation of mitotic sister chromatid separation (GO:0010965)2.71055398
159regulation of acyl-CoA biosynthetic process (GO:0050812)2.70770896
160IMP biosynthetic process (GO:0006188)2.70467420
161purine nucleobase biosynthetic process (GO:0009113)2.67037883
162resolution of meiotic recombination intermediates (GO:0000712)2.66059843
163telomere maintenance via telomerase (GO:0007004)2.63957166
164mitotic spindle assembly checkpoint (GO:0007094)2.63796957
165IMP metabolic process (GO:0046040)2.61798222
166somatic recombination of immunoglobulin gene segments (GO:0016447)2.59423292
167spindle assembly checkpoint (GO:0071173)2.58916409
168DNA replication-independent nucleosome assembly (GO:0006336)2.58773332
169DNA replication-independent nucleosome organization (GO:0034724)2.58773332
170establishment of chromosome localization (GO:0051303)2.55073723
171RNA-dependent DNA replication (GO:0006278)2.55066285
172regulation of sulfur metabolic process (GO:0042762)2.52037994
173pore complex assembly (GO:0046931)2.50848371
174meiotic chromosome segregation (GO:0045132)2.50004744
175regulation of chromosome segregation (GO:0051983)2.49125304
176regulation of centriole replication (GO:0046599)2.48496244
177negative regulation of nuclear division (GO:0051784)2.44423171
178nucleobase biosynthetic process (GO:0046112)2.43515386
179formation of translation preinitiation complex (GO:0001731)2.41403167
180regulation of Wnt signaling pathway involved in heart development (GO:0003307)2.39859864
181sister chromatid cohesion (GO:0007062)2.39815216
182branched-chain amino acid metabolic process (GO:0009081)2.38268987
183tRNA aminoacylation for protein translation (GO:0006418)2.37672655
184AMP metabolic process (GO:0046033)2.37570713
185intra-S DNA damage checkpoint (GO:0031573)2.36115482
186water-soluble vitamin biosynthetic process (GO:0042364)2.35671300
187protein complex localization (GO:0031503)2.35301835
188positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.34249189
189positive regulation of mitotic sister chromatid separation (GO:1901970)2.34249189
190positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.34249189
191amino acid activation (GO:0043038)2.32110096
192tRNA aminoacylation (GO:0043039)2.32110096
193kinetochore organization (GO:0051383)2.31681519
194aspartate family amino acid catabolic process (GO:0009068)2.31599462
195negative regulation of mitosis (GO:0045839)2.30239125
196hyperosmotic salinity response (GO:0042538)2.29476553
197anterior/posterior axis specification, embryo (GO:0008595)2.29078158
198negative regulation of meiotic cell cycle (GO:0051447)2.29026562

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GBX2_23144817_ChIP-Seq_PC3_Human5.08029271
2EZH2_22144423_ChIP-Seq_EOC_Human4.33293398
3E2F7_22180533_ChIP-Seq_HELA_Human3.40692321
4TAF15_26573619_Chip-Seq_HEK293_Human3.37767761
5SALL1_21062744_ChIP-ChIP_HESCs_Human3.22665578
6TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.84703625
7KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.79417690
8GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.77331926
9SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.72097639
10ZFP57_27257070_Chip-Seq_ESCs_Mouse2.65293926
11ELK1_19687146_ChIP-ChIP_HELA_Human2.59674159
12CTBP2_25329375_ChIP-Seq_LNCAP_Human2.57607730
13E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.57396939
14SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.52452853
15* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.41612234
16GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.32180611
17GABP_17652178_ChIP-ChIP_JURKAT_Human2.31497428
18JARID2_20064375_ChIP-Seq_MESCs_Mouse2.29540492
19MYC_18555785_ChIP-Seq_MESCs_Mouse2.28536474
20POU3F2_20337985_ChIP-ChIP_501MEL_Human2.27967789
21SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.25648503
22E2F4_17652178_ChIP-ChIP_JURKAT_Human2.23138195
23REST_21632747_ChIP-Seq_MESCs_Mouse2.23114562
24CTBP1_25329375_ChIP-Seq_LNCAP_Human2.21939152
25P300_19829295_ChIP-Seq_ESCs_Human2.20331926
26AR_21909140_ChIP-Seq_LNCAP_Human2.20018576
27NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.17332467
28PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.12666724
29SMAD4_21799915_ChIP-Seq_A2780_Human2.12547331
30BMI1_23680149_ChIP-Seq_NPCS_Mouse2.11528054
31SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.07811022
32FUS_26573619_Chip-Seq_HEK293_Human2.07096780
33SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.06661447
34EZH2_27304074_Chip-Seq_ESCs_Mouse2.04612077
35EED_16625203_ChIP-ChIP_MESCs_Mouse2.03494691
36JARID2_20075857_ChIP-Seq_MESCs_Mouse1.87636740
37EZH2_18974828_ChIP-Seq_MESCs_Mouse1.87611531
38RNF2_18974828_ChIP-Seq_MESCs_Mouse1.87611531
39REST_18959480_ChIP-ChIP_MESCs_Mouse1.86475512
40VDR_22108803_ChIP-Seq_LS180_Human1.83721151
41SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.80993706
42CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.79931732
43SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.79384316
44PADI4_21655091_ChIP-ChIP_MCF-7_Human1.78851944
45PIAS1_25552417_ChIP-Seq_VCAP_Human1.77987370
46PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.76904796
47SMAD_19615063_ChIP-ChIP_OVARY_Human1.75154165
48MTF2_20144788_ChIP-Seq_MESCs_Mouse1.72385125
49RNF2_27304074_Chip-Seq_NSC_Mouse1.70750679
50CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.70327731
51PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.70087127
52EST1_17652178_ChIP-ChIP_JURKAT_Human1.69774493
53TOP2B_26459242_ChIP-Seq_MCF-7_Human1.69746297
54ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.69104731
55ER_23166858_ChIP-Seq_MCF-7_Human1.67391036
56OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.67126720
57FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.66161458
58SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.60731845
59FLI1_27457419_Chip-Seq_LIVER_Mouse1.60687546
60* NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.60211941
61SMAD3_21741376_ChIP-Seq_EPCs_Human1.59983311
62CBX2_27304074_Chip-Seq_ESCs_Mouse1.56523391
63POU5F1_16153702_ChIP-ChIP_HESCs_Human1.53965976
64AR_25329375_ChIP-Seq_VCAP_Human1.53842397
65MYCN_18555785_ChIP-Seq_MESCs_Mouse1.52433927
66SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.51537181
67RARB_27405468_Chip-Seq_BRAIN_Mouse1.50397582
68MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.50390076
69CREB1_15753290_ChIP-ChIP_HEK293T_Human1.49304598
70RNF2_27304074_Chip-Seq_ESCs_Mouse1.49218866
71HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.49011719
72* RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.45358247
73PCGF2_27294783_Chip-Seq_ESCs_Mouse1.44123599
74NELFA_20434984_ChIP-Seq_ESCs_Mouse1.44018144
75YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.43607675
76FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.42888890
77IKZF1_21737484_ChIP-ChIP_HCT116_Human1.41755099
78CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.41614404
79SUZ12_27294783_Chip-Seq_ESCs_Mouse1.41120209
80IGF1R_20145208_ChIP-Seq_DFB_Human1.40504788
81SOX2_21211035_ChIP-Seq_LN229_Gbm1.40055839
82NANOG_16153702_ChIP-ChIP_HESCs_Human1.39380204
83STAT3_23295773_ChIP-Seq_U87_Human1.38568532
84UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.38247183
85EZH2_27294783_Chip-Seq_ESCs_Mouse1.37617501
86AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.36561442
87E2F1_21310950_ChIP-Seq_MCF-7_Human1.36512034
88SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.36353903
89* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.36279920
90FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.35812935
91* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.35100186
92JUN_21703547_ChIP-Seq_K562_Human1.34515382
93AR_21572438_ChIP-Seq_LNCaP_Human1.32661174
94TCF4_23295773_ChIP-Seq_U87_Human1.31984210
95NANOG_18555785_Chip-Seq_ESCs_Mouse1.31783620
96WT1_19549856_ChIP-ChIP_CCG9911_Human1.31292325
97EWS_26573619_Chip-Seq_HEK293_Human1.29933164
98MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.28569252
99VDR_23849224_ChIP-Seq_CD4+_Human1.28211291
100CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.27306259
101DROSHA_22980978_ChIP-Seq_HELA_Human1.25566686
102TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.25364461
103ZFX_18555785_ChIP-Seq_MESCs_Mouse1.23816392
104KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.23610900
105KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.23610900
106KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.23610900
107TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.22924371
108RUNX2_22187159_ChIP-Seq_PCA_Human1.21611067
109PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.20981201
110SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.19557501
111ARNT_22903824_ChIP-Seq_MCF-7_Human1.18402318
112EZH2_27294783_Chip-Seq_NPCs_Mouse1.17078927
113HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.17042451
114CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.15838781
115E2F1_18555785_Chip-Seq_ESCs_Mouse1.15709215
116P53_22387025_ChIP-Seq_ESCs_Mouse1.15379323
117MYC_19079543_ChIP-ChIP_MESCs_Mouse1.14762642
118SOX2_16153702_ChIP-ChIP_HESCs_Human1.13659636
119EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.13178488
120RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.11410760
121MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.11373893
122NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.11273037
123DCP1A_22483619_ChIP-Seq_HELA_Human1.11082728
124JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.10887892
125CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.10868240
126MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.10760920
127SOX17_20123909_ChIP-Seq_XEN_Mouse1.09339609
128PRDM14_20953172_ChIP-Seq_ESCs_Human1.08864356
129ZNF274_21170338_ChIP-Seq_K562_Hela1.08210690
130NR3C1_23031785_ChIP-Seq_PC12_Mouse1.07990067
131SOX9_26525672_Chip-Seq_HEART_Mouse1.07779141
132IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.07197481
133TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.06890440
134RBPJ_22232070_ChIP-Seq_NCS_Mouse1.06727390
135AHR_22903824_ChIP-Seq_MCF-7_Human1.06457410
136ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.06143144
137ETS1_20019798_ChIP-Seq_JURKAT_Human1.05842415
138MYC_18940864_ChIP-ChIP_HL60_Human1.05484066
139CMYC_18555785_Chip-Seq_ESCs_Mouse1.05328374
140GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.04644301
141MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.04287175
142TBX3_20139965_ChIP-Seq_ESCs_Mouse1.04235625
143TP53_18474530_ChIP-ChIP_U2OS_Human1.03837339
144SUZ12_18555785_Chip-Seq_ESCs_Mouse1.03467901
145TBX3_20139965_ChIP-Seq_MESCs_Mouse1.03228458
146STAT3_18555785_Chip-Seq_ESCs_Mouse1.02638585
147SUZ12_27294783_Chip-Seq_NPCs_Mouse1.01847914
148FOXM1_23109430_ChIP-Seq_U2OS_Human1.01525097
149FOXM1_26456572_ChIP-Seq_MCF-7_Human1.01095321
150ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.00754568
151PCGF2_27294783_Chip-Seq_NPCs_Mouse1.00707218
152* KDM2B_26808549_Chip-Seq_REH_Human1.00650348
153FOXP3_21729870_ChIP-Seq_TREG_Human0.99710998
154KLF5_20875108_ChIP-Seq_MESCs_Mouse0.98863164
155* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.98616850
156TAL1_26923725_Chip-Seq_HPCs_Mouse0.98058718
157NRF2_20460467_ChIP-Seq_MEFs_Mouse0.97606450
158NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.97606450
159* HOXB4_20404135_ChIP-ChIP_EML_Mouse0.97530025
160POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.97022157
161SOX2_18555785_Chip-Seq_ESCs_Mouse0.96971980
162P53_22127205_ChIP-Seq_FIBROBLAST_Human0.96918231
163EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.96787027
164NFE2_27457419_Chip-Seq_LIVER_Mouse0.96573615
165SRF_21415370_ChIP-Seq_HL-1_Mouse0.95833419
166CBP_20019798_ChIP-Seq_JUKART_Human0.95794267
167POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.95655045
168CDX2_22108803_ChIP-Seq_LS180_Human0.95549024
169* TTF2_22483619_ChIP-Seq_HELA_Human0.93961173

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern4.33648481
2MP0004859_abnormal_synaptic_plasticity3.83929600
3MP0003941_abnormal_skin_development3.68162948
4MP0009046_muscle_twitch3.66946465
5MP0009745_abnormal_behavioral_response3.41921556
6MP0003635_abnormal_synaptic_transmissio3.39812674
7MP0002064_seizures3.26566232
8MP0002822_catalepsy3.24951662
9MP0001968_abnormal_touch/_nociception3.17158778
10MP0003122_maternal_imprinting3.11999093
11MP0002736_abnormal_nociception_after3.07300566
12MP0005646_abnormal_pituitary_gland3.02958469
13MP0003787_abnormal_imprinting3.02500168
14MP0002063_abnormal_learning/memory/cond2.86001568
15MP0010352_gastrointestinal_tract_polyps2.84728183
16MP0002572_abnormal_emotion/affect_behav2.82085183
17MP0008058_abnormal_DNA_repair2.78401707
18MP0002272_abnormal_nervous_system2.68137059
19MP0001501_abnormal_sleep_pattern2.64309266
20MP0002735_abnormal_chemical_nociception2.61442485
21MP0009780_abnormal_chondrocyte_physiolo2.54818901
22MP0004957_abnormal_blastocyst_morpholog2.40729089
23MP0002734_abnormal_mechanical_nocicepti2.40249320
24MP0002876_abnormal_thyroid_physiology2.33655038
25MP0004270_analgesia2.28129227
26MP0001529_abnormal_vocalization2.26741498
27MP0006276_abnormal_autonomic_nervous2.20416037
28MP0008057_abnormal_DNA_replication2.17377432
29MP0003693_abnormal_embryo_hatching2.13793185
30MP0010234_abnormal_vibrissa_follicle2.12922657
31MP0010094_abnormal_chromosome_stability2.08045158
32MP0001486_abnormal_startle_reflex2.07616950
33MP0005645_abnormal_hypothalamus_physiol2.06733804
34MP0003283_abnormal_digestive_organ2.05770884
35MP0002067_abnormal_sensory_capabilities2.04161420
36MP0001188_hyperpigmentation2.02016808
37MP0001440_abnormal_grooming_behavior1.99067420
38MP0003111_abnormal_nucleus_morphology1.98598860
39MP0008932_abnormal_embryonic_tissue1.92054217
40MP0001984_abnormal_olfaction1.84528826
41MP0004142_abnormal_muscle_tone1.81630651
42MP0001986_abnormal_taste_sensitivity1.79300915
43MP0001970_abnormal_pain_threshold1.78917980
44MP0003937_abnormal_limbs/digits/tail_de1.70465523
45MP0005423_abnormal_somatic_nervous1.70318820
46MP0002733_abnormal_thermal_nociception1.67550821
47MP0004924_abnormal_behavior1.67354649
48MP0005386_behavior/neurological_phenoty1.67354649
49MP0002837_dystrophic_cardiac_calcinosis1.66560708
50MP0003879_abnormal_hair_cell1.62167396
51MP0001905_abnormal_dopamine_level1.62090188
52MP0008877_abnormal_DNA_methylation1.60457506
53MP0002557_abnormal_social/conspecific_i1.59939687
54MP0003136_yellow_coat_color1.59713323
55MP0003077_abnormal_cell_cycle1.59623176
56MP0001293_anophthalmia1.56702835
57MP0003121_genomic_imprinting1.55384967
58MP0008007_abnormal_cellular_replicative1.54430281
59MP0003567_abnormal_fetal_cardiomyocyte1.53976148
60MP0003718_maternal_effect1.53940658
61MP0005171_absent_coat_pigmentation1.51409240
62MP0003183_abnormal_peptide_metabolism1.46912142
63MP0009703_decreased_birth_body1.46226012
64MP0004272_abnormal_basement_membrane1.45018227
65MP0002184_abnormal_innervation1.40124905
66MP0009672_abnormal_birth_weight1.39565683
67MP0005248_abnormal_Harderian_gland1.39544116
68MP0002233_abnormal_nose_morphology1.38525111
69MP0002938_white_spotting1.38416777
70MP0002084_abnormal_developmental_patter1.38028035
71MP0010386_abnormal_urinary_bladder1.37016175
72MP0010368_abnormal_lymphatic_system1.34285224
73MP0003890_abnormal_embryonic-extraembry1.33717891
74MP0002090_abnormal_vision1.32945603
75MP0002102_abnormal_ear_morphology1.31861344
76MP0010030_abnormal_orbit_morphology1.31370639
77MP0008569_lethality_at_weaning1.27776551
78MP0000013_abnormal_adipose_tissue1.27772763
79MP0001730_embryonic_growth_arrest1.27066406
80MP0003195_calcinosis1.25969432
81MP0002877_abnormal_melanocyte_morpholog1.24070289
82MP0003646_muscle_fatigue1.23469570
83MP0002697_abnormal_eye_size1.22969975
84MP0006072_abnormal_retinal_apoptosis1.22506348
85MP0010678_abnormal_skin_adnexa1.22400929
86MP0004811_abnormal_neuron_physiology1.21975698
87MP0002009_preneoplasia1.21885790
88MP0003123_paternal_imprinting1.21589274
89MP0000537_abnormal_urethra_morphology1.21274174
90MP0002066_abnormal_motor_capabilities/c1.20035784
91MP0002254_reproductive_system_inflammat1.18828990
92MP0000647_abnormal_sebaceous_gland1.16501455
93MP0002085_abnormal_embryonic_tissue1.15232308
94MP0004133_heterotaxia1.13616402
95MP0005367_renal/urinary_system_phenotyp1.13178067
96MP0000516_abnormal_urinary_system1.13178067
97MP0000778_abnormal_nervous_system1.12023548
98MP0000462_abnormal_digestive_system1.10975307
99MP0002882_abnormal_neuron_morphology1.08240086
100MP0003186_abnormal_redox_activity1.07858286
101MP0001286_abnormal_eye_development1.06311569
102MP0001502_abnormal_circadian_rhythm1.05171658
103MP0000762_abnormal_tongue_morphology1.02675117
104MP0003011_delayed_dark_adaptation1.02281432
105MP0000955_abnormal_spinal_cord1.02181189
106MP0003943_abnormal_hepatobiliary_system1.01684973
107MP0001697_abnormal_embryo_size1.01413777
108MP0008789_abnormal_olfactory_epithelium1.00717919
109MP0005380_embryogenesis_phenotype1.00144248
110MP0001672_abnormal_embryogenesis/_devel1.00144248
111MP0001963_abnormal_hearing_physiology0.99475453
112MP0009697_abnormal_copulation0.98209400
113MP0004043_abnormal_pH_regulation0.97974660
114MP0004197_abnormal_fetal_growth/weight/0.97773519
115MP0001299_abnormal_eye_distance/0.96320100
116MP0009384_cardiac_valve_regurgitation0.95874377
117MP0004084_abnormal_cardiac_muscle0.93720191
118MP0010307_abnormal_tumor_latency0.93105810
119MP0003633_abnormal_nervous_system0.92816618
120MP0000358_abnormal_cell_content/0.92359497
121MP0003755_abnormal_palate_morphology0.92249237
122MP0001324_abnormal_eye_pigmentation0.91650046
123MP0008872_abnormal_physiological_respon0.91308663
124MP0003984_embryonic_growth_retardation0.91295065
125MP0004858_abnormal_nervous_system0.91215657
126MP0002909_abnormal_adrenal_gland0.91053983
127MP0000631_abnormal_neuroendocrine_gland0.90945457
128MP0003119_abnormal_digestive_system0.90628862
129MP0002088_abnormal_embryonic_growth/wei0.90180330
130MP0005394_taste/olfaction_phenotype0.89482202
131MP0005499_abnormal_olfactory_system0.89482202
132MP0005187_abnormal_penis_morphology0.89335997
133MP0004484_altered_response_of0.89123969
134MP0002069_abnormal_eating/drinking_beha0.89111221
135MP0005253_abnormal_eye_physiology0.89071337
136MP0001661_extended_life_span0.88858265
137MP0000432_abnormal_head_morphology0.88702415
138MP0005551_abnormal_eye_electrophysiolog0.87775667
139MP0000751_myopathy0.87442938
140MP0000350_abnormal_cell_proliferation0.86386048
141MP0001664_abnormal_digestion0.86148154
142MP0004085_abnormal_heartbeat0.86029314
143MP0000427_abnormal_hair_cycle0.85762144
144MP0002332_abnormal_exercise_endurance0.85699672
145MP0003631_nervous_system_phenotype0.83661417
146MP0001177_atelectasis0.83349477
147MP0002796_impaired_skin_barrier0.82889369
148MP0005395_other_phenotype0.82317550
149MP0000383_abnormal_hair_follicle0.82105356
150MP0001145_abnormal_male_reproductive0.79918034
151MP0000653_abnormal_sex_gland0.79589804
152MP0002229_neurodegeneration0.79355388
153MP0002111_abnormal_tail_morphology0.78987988
154MP0005220_abnormal_exocrine_pancreas0.78696746
155MP0002638_abnormal_pupillary_reflex0.78354437
156MP0000049_abnormal_middle_ear0.78037227
157MP0001879_abnormal_lymphatic_vessel0.77964515
158MP0008260_abnormal_autophagy0.77190642
159MP0002080_prenatal_lethality0.77078288
160MP0005408_hypopigmentation0.76623554
161MP0009250_abnormal_appendicular_skeleto0.75972428
162MP0005275_abnormal_skin_tensile0.75730819
163MP0005391_vision/eye_phenotype0.75458133
164MP0005084_abnormal_gallbladder_morpholo0.75136607
165MP0002210_abnormal_sex_determination0.74951758
166MP0002152_abnormal_brain_morphology0.74753293
167MP0000681_abnormal_thyroid_gland0.74237309
168MP0003221_abnormal_cardiomyocyte_apopto0.73990900
169MP0004233_abnormal_muscle_weight0.72190760
170MP0000026_abnormal_inner_ear0.68636930
171MP0005535_abnormal_body_temperature0.68496069
172MP0004215_abnormal_myocardial_fiber0.67488518
173MP0005379_endocrine/exocrine_gland_phen0.67488157
174MP0002653_abnormal_ependyma_morphology0.64614702
175MP0001542_abnormal_bone_strength0.64181859
176MP0008874_decreased_physiological_sensi0.63920509
177MP0002163_abnormal_gland_morphology0.63364631
178MP0002752_abnormal_somatic_nervous0.62762551
179MP0006035_abnormal_mitochondrial_morpho0.61733906
180MP0001943_abnormal_respiration0.59192859
181MP0004742_abnormal_vestibular_system0.58210689
182MP0002751_abnormal_autonomic_nervous0.57559348
183MP0003632_abnormal_nervous_system0.56416061
184MP0004036_abnormal_muscle_relaxation0.55639340
185MP0004885_abnormal_endolymph0.52988854
186MP0008004_abnormal_stomach_pH0.52752652
187MP0006292_abnormal_olfactory_placode0.48092589
188MP0000230_abnormal_systemic_arterial0.47580878

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)7.48874959
2Atonic seizures (HP:0010819)6.12819417
3Febrile seizures (HP:0002373)5.43553259
4Epileptic encephalopathy (HP:0200134)5.35665856
5Hyperventilation (HP:0002883)5.24120569
6Abnormal hair whorl (HP:0010721)5.10653416
7Focal seizures (HP:0007359)4.48374355
8Absence seizures (HP:0002121)4.17205671
9Dialeptic seizures (HP:0011146)3.82458796
10Acute necrotizing encephalopathy (HP:0006965)3.81234352
11Abnormal mitochondria in muscle tissue (HP:0008316)3.77572556
12Pheochromocytoma (HP:0002666)3.64456114
13Gait imbalance (HP:0002141)3.63711569
14Failure to thrive in infancy (HP:0001531)3.63425007
15Medial flaring of the eyebrow (HP:0010747)3.56770945
16Congenital primary aphakia (HP:0007707)3.53569724
17Oligomenorrhea (HP:0000876)3.53439588
18Generalized tonic-clonic seizures (HP:0002069)3.49696573
19Abnormality of the labia minora (HP:0012880)3.49200267
20Neuroendocrine neoplasm (HP:0100634)3.47474933
21Nephrogenic diabetes insipidus (HP:0009806)3.41534072
22Progressive macrocephaly (HP:0004481)3.40475325
23Progressive cerebellar ataxia (HP:0002073)3.40022738
24Colon cancer (HP:0003003)3.37549887
25Poor suck (HP:0002033)3.37212898
26Myokymia (HP:0002411)3.35622809
27Polyphagia (HP:0002591)3.29166092
28Hypothermia (HP:0002045)3.22546960
29Visual hallucinations (HP:0002367)3.12070727
30Broad-based gait (HP:0002136)3.02117103
31Ependymoma (HP:0002888)3.00512664
32Mitochondrial inheritance (HP:0001427)2.97087397
33Cortical dysplasia (HP:0002539)2.96732060
34Abnormal eating behavior (HP:0100738)2.86049526
35Hypoglycemic seizures (HP:0002173)2.82484800
36Acute encephalopathy (HP:0006846)2.79783504
37Gonadotropin excess (HP:0000837)2.76706199
38Poor coordination (HP:0002370)2.72422102
39Biliary tract neoplasm (HP:0100574)2.69072587
40Protruding tongue (HP:0010808)2.68626269
41Resting tremor (HP:0002322)2.68314746
42Gaze-evoked nystagmus (HP:0000640)2.67772398
43Progressive inability to walk (HP:0002505)2.65379856
44Epileptiform EEG discharges (HP:0011182)2.62399909
45Narrow nasal bridge (HP:0000446)2.61957135
46Increased CSF lactate (HP:0002490)2.61776622
47Genital tract atresia (HP:0001827)2.57919676
48Hyperinsulinemic hypoglycemia (HP:0000825)2.57786284
49Vaginal atresia (HP:0000148)2.57463682
50Specific learning disability (HP:0001328)2.56443706
51Blue irides (HP:0000635)2.54459028
52Rhabdomyosarcoma (HP:0002859)2.53147534
53Breast carcinoma (HP:0003002)2.52164289
54Hepatocellular necrosis (HP:0001404)2.50538029
55Limb dystonia (HP:0002451)2.48267059
56Neoplasm of the small intestine (HP:0100833)2.47564350
57Papillary thyroid carcinoma (HP:0002895)2.45237921
58Glioma (HP:0009733)2.41769945
59Neoplasm of the colon (HP:0100273)2.40360469
60Hyperthyroidism (HP:0000836)2.38214785
61EEG with generalized epileptiform discharges (HP:0011198)2.36993036
62Abnormal biliary tract morphology (HP:0012440)2.36085110
63Neoplasm of the rectum (HP:0100743)2.34679476
64Abnormality of glycolysis (HP:0004366)2.33144069
65Increased serum pyruvate (HP:0003542)2.33144069
66Tubulointerstitial nephritis (HP:0001970)2.32312477
67Astrocytoma (HP:0009592)2.31761740
68Abnormality of the astrocytes (HP:0100707)2.31761740
69Abnormality of binocular vision (HP:0011514)2.30736431
70Diplopia (HP:0000651)2.30736431
71Dysdiadochokinesis (HP:0002075)2.28803454
72Fetal akinesia sequence (HP:0001989)2.28618054
73Hyperglycinemia (HP:0002154)2.26894915
74Impaired vibration sensation in the lower limbs (HP:0002166)2.25597721
75Hypoglycemic coma (HP:0001325)2.25525918
76Inability to walk (HP:0002540)2.25103415
77Hypsarrhythmia (HP:0002521)2.25076493
78Exercise-induced muscle cramps (HP:0003710)2.24412794
79Short tibia (HP:0005736)2.21506397
80Abnormality of serine family amino acid metabolism (HP:0010894)2.20806497
81Abnormality of glycine metabolism (HP:0010895)2.20806497
82Volvulus (HP:0002580)2.20449247
83Stenosis of the external auditory canal (HP:0000402)2.19749400
84Esotropia (HP:0000565)2.18032703
85Truncal ataxia (HP:0002078)2.17574853
86Hyperglycinuria (HP:0003108)2.15400130
87Optic disc pallor (HP:0000543)2.14745108
88Absent speech (HP:0001344)2.12211899
89Aplasia/Hypoplasia of the lens (HP:0008063)2.11380475
90Neoplasm of the adrenal gland (HP:0100631)2.10294592
91Bifid tongue (HP:0010297)2.10274536
92Chromsome breakage (HP:0040012)2.10194476
93Degeneration of anterior horn cells (HP:0002398)2.10012751
94Abnormality of the anterior horn cell (HP:0006802)2.10012751
95Abnormal lung lobation (HP:0002101)2.08019019
96Thyroid carcinoma (HP:0002890)2.07328649
97Excessive salivation (HP:0003781)2.07200822
98Drooling (HP:0002307)2.07200822
99Sleep apnea (HP:0010535)2.07033153
100Sensory axonal neuropathy (HP:0003390)2.06298327
101Patchy hypopigmentation of hair (HP:0011365)2.05374354
102Hypoventilation (HP:0002791)2.04843749
103Spastic diplegia (HP:0001264)2.04316273
104Medulloblastoma (HP:0002885)2.04272490
105Median cleft lip (HP:0000161)2.03434550
106Anxiety (HP:0000739)2.02282782
107Hip dysplasia (HP:0001385)2.02198287
108Nephroblastoma (Wilms tumor) (HP:0002667)2.00552214
109Embryonal renal neoplasm (HP:0011794)1.97915778
110Abnormality of chromosome stability (HP:0003220)1.97902278
111Abnormality of pain sensation (HP:0010832)1.97591354
112Impaired pain sensation (HP:0007328)1.97591354
113Ovarian neoplasm (HP:0100615)1.97377693
114Abnormality of serum amino acid levels (HP:0003112)1.96860928
115Dyschromatopsia (HP:0007641)1.96473556
116Long foot (HP:0001833)1.96050818
117Neoplasm of the peripheral nervous system (HP:0100007)1.91622672
118Nephronophthisis (HP:0000090)1.91452285
119Microglossia (HP:0000171)1.91392261
120Angiofibromas (HP:0010615)1.91251529
121Adenoma sebaceum (HP:0009720)1.91251529
122Generalized hypotonia (HP:0001290)1.91189647
123Abnormality of methionine metabolism (HP:0010901)1.89785095
124Bradykinesia (HP:0002067)1.89343410
125Aplasia/Hypoplasia of the tibia (HP:0005772)1.88778900
126Leukodystrophy (HP:0002415)1.87649244
127Amblyopia (HP:0000646)1.87254042
128Labial hypoplasia (HP:0000066)1.85436462
129Agnosia (HP:0010524)1.84962009
130Akinesia (HP:0002304)1.84568755
131Autoamputation (HP:0001218)1.84407495
132Abnormality of aspartate family amino acid metabolism (HP:0010899)1.83252288
133Fair hair (HP:0002286)1.82790893
134Multiple enchondromatosis (HP:0005701)1.82382534
135Thyroid-stimulating hormone excess (HP:0002925)1.80788618
136Gastrointestinal atresia (HP:0002589)1.80324885
137Intestinal atresia (HP:0011100)1.79532341
138Poor eye contact (HP:0000817)1.79451046
139Broad foot (HP:0001769)1.79363199
140Depression (HP:0000716)1.78717299
141Shoulder girdle muscle weakness (HP:0003547)1.78616813
142White forelock (HP:0002211)1.77962403
143Uterine neoplasm (HP:0010784)1.77691546
144Generalized hypopigmentation of hair (HP:0011358)1.77332117
145Chronic bronchitis (HP:0004469)1.75297085
146Scanning speech (HP:0002168)1.74945529
147Impaired social interactions (HP:0000735)1.74680101
148Abnormal social behavior (HP:0012433)1.74680101
149Abnormality of the renal medulla (HP:0100957)1.73526548
150Short foot (HP:0001773)1.71939142
151Methylmalonic acidemia (HP:0002912)1.71682407
152Hypoplastic female external genitalia (HP:0012815)1.71103277
153Postaxial hand polydactyly (HP:0001162)1.69472486
154Breech presentation (HP:0001623)1.69083599
155Atrophy/Degeneration involving motor neurons (HP:0007373)1.68793639
156Delayed gross motor development (HP:0002194)1.68458197
157Generalized myoclonic seizures (HP:0002123)1.68447518
158Meckel diverticulum (HP:0002245)1.68027807
159Exercise intolerance (HP:0003546)1.67747224
160Pancreatic fibrosis (HP:0100732)1.67043201
161X-linked dominant inheritance (HP:0001423)1.65410054
162Lactic acidosis (HP:0003128)1.64305838
163Impaired vibratory sensation (HP:0002495)1.62457228
164Chromosomal breakage induced by crosslinking agents (HP:0003221)1.62258914
165Symptomatic seizures (HP:0011145)1.62045570
166Respiratory failure (HP:0002878)1.61944424
167Absent eyebrow (HP:0002223)1.60655002
168Dynein arm defect of respiratory motile cilia (HP:0012255)1.60069774
169Abnormal protein glycosylation (HP:0012346)1.59919701
170Abnormal glycosylation (HP:0012345)1.59919701
171Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.59919701
172Abnormal protein N-linked glycosylation (HP:0012347)1.59919701
173Type I transferrin isoform profile (HP:0003642)1.59133322
174Abnormality of the ileum (HP:0001549)1.58741487
175Pancreatic cysts (HP:0001737)1.57874352
176Postaxial foot polydactyly (HP:0001830)1.57783092
177Cutaneous syndactyly (HP:0012725)1.57261965
178Short middle phalanx of the 5th finger (HP:0004220)1.56251655
179Intestinal polyposis (HP:0200008)1.54886909
180Increased nuchal translucency (HP:0010880)1.53746581
181Aplasia/Hypoplasia of the tongue (HP:0010295)1.53500315
182Fibular aplasia (HP:0002990)1.53283237
183Aplasia/hypoplasia of the humerus (HP:0006507)1.52577989
184Cutaneous finger syndactyly (HP:0010554)1.52357946
185Duodenal stenosis (HP:0100867)1.51908360
186Small intestinal stenosis (HP:0012848)1.51908360

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK6.78720133
2MAP3K124.10732952
3AKT33.54392092
4MAP2K73.48555520
5NTRK33.37462348
6TSSK63.08700802
7MAP3K42.99366196
8NUAK12.60427043
9PLK22.52666381
10PRPF4B2.52202972
11TTK2.49302527
12PBK2.47427130
13EIF2AK32.25743490
14BUB12.23063935
15LATS12.16785024
16SRPK12.16235749
17CDK192.10939645
18SIK31.99947829
19TRIM281.89426670
20LMTK21.87931590
21MAP2K41.84729750
22CDC71.74364773
23DAPK11.70614605
24EPHA41.70422603
25NEK11.69728254
26SGK21.68271857
27STK38L1.67140436
28CCNB11.63222727
29MINK11.60242355
30PDK31.56929168
31PDK41.56929168
32CSNK1G11.55053659
33OXSR11.53770993
34STK31.53461014
35NEK91.47961536
36GRK51.43315193
37ZAK1.43128845
38BRSK21.39862258
39PASK1.36396031
40STK391.34509441
41SGK4941.34276482
42SGK2231.34276482
43ADRBK21.33338157
44WEE11.31574389
45ERBB41.27494510
46PRKCG1.27130511
47CSNK1G31.26658344
48MYLK1.24228612
49PLK11.23951471
50NTRK21.22174847
51TAF11.21254259
52DAPK21.20923562
53BMPR21.20671846
54PLK41.20419509
55CSNK1A1L1.19684043
56EIF2AK11.18607260
57BCR1.16783581
58BRD41.16342830
59TNIK1.14503256
60NME11.12856258
61MAPK131.12695218
62BRAF1.11302498
63GRK71.11253653
64PDK21.09634359
65TGFBR11.06471470
66FLT31.06258903
67RPS6KA41.05989510
68PRKCE1.03495676
69CAMK1G1.02642220
70CAMK2A1.02613152
71BCKDK1.01814628
72SGK31.00025023
73FGFR10.97113532
74MET0.96517519
75MKNK20.95051030
76MARK10.95018606
77YES10.93548789
78CDK60.93381803
79CDK80.91817600
80EIF2AK20.90999980
81MAP3K90.88775229
82ARAF0.88692264
83ACVR1B0.88206866
84ATM0.86175181
85ERBB30.86148253
86BMPR1B0.82870194
87FGFR20.82554960
88CDK50.82439908
89PRKG20.81620202
90MAP3K100.79972046
91TNK20.78894587
92VRK20.77291381
93CAMK2B0.76798094
94RIPK40.74408278
95ADRBK10.71548144
96ATR0.68923450
97NLK0.67862021
98WNK30.67154559
99TIE10.65589677
100NEK60.64362306
101MAP4K20.63656053
102SCYL20.63507756
103PLK30.62480453
104VRK10.62117966
105DYRK20.61376472
106CAMKK20.57781581
107CHEK20.57634009
108CDK30.57265349
109SGK10.55583812
110STK160.55378614
111FES0.54891804
112DMPK0.54889104
113CDK180.54707064
114CAMK2D0.54536621
115PTK2B0.54108333
116CAMK2G0.52552633
117PIK3CG0.52089376
118MUSK0.52017677
119AURKB0.50741274
120PRKCH0.50394801
121PNCK0.49633157
122ALK0.49329335
123WNK40.48675532
124PAK20.46349147
125FER0.46112947
126FRK0.46109918
127CDK140.46109113
128CHEK10.45159788
129RPS6KB10.45020592
130UHMK10.44790768
131CDK150.41912574
132CAMK10.41753739
133PRKDC0.40867668
134PAK40.40670925
135INSRR0.40372321
136NEK20.40358421
137PRKACA0.39988094
138DYRK30.39339526
139RPS6KA20.38910893
140KSR10.38559667
141MST40.38384147
142OBSCN0.37254467
143PHKG20.36394526
144PHKG10.36394526
145DYRK1A0.36354476
146PINK10.35701385
147EGFR0.35642268
148DAPK30.32744018
149MKNK10.32531850
150CSNK2A10.32443934
151CSNK1E0.31850438
152CDK11A0.30808061
153PRKCB0.30415954
154ROCK20.30214655
155CSNK2A20.29961218
156PDGFRA0.29670712
157NTRK10.29545081
158MAPK70.29529090
159PRKCA0.28852612
160RPS6KA30.28392970
161MAP3K60.28206215
162PIK3CA0.28117965
163PRKG10.27989523
164GRK10.27975887
165MAP2K10.27307117
166STK240.26785807
167CSNK1A10.26744806
168CAMK40.24313154
169CSNK1G20.23708480
170PAK60.23369111

Predicted pathways (KEGG)

RankGene SetZ-score
1Collecting duct acid secretion_Homo sapiens_hsa049664.64248465
2Synaptic vesicle cycle_Homo sapiens_hsa047214.46900371
3Nicotine addiction_Homo sapiens_hsa050334.11223814
4Vibrio cholerae infection_Homo sapiens_hsa051103.02152316
5Non-homologous end-joining_Homo sapiens_hsa034502.93055918
6Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.90679411
7Propanoate metabolism_Homo sapiens_hsa006402.86977667
8Oxidative phosphorylation_Homo sapiens_hsa001902.85533411
9Mismatch repair_Homo sapiens_hsa034302.78271925
10GABAergic synapse_Homo sapiens_hsa047272.70927681
11Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.64353521
12Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.54897175
13Morphine addiction_Homo sapiens_hsa050322.39849642
14Olfactory transduction_Homo sapiens_hsa047402.31507102
15Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.28370542
16Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.20027223
17Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.16869631
18Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051202.07962794
19Circadian entrainment_Homo sapiens_hsa047132.06513923
20RNA transport_Homo sapiens_hsa030131.98503050
21Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.98281488
22Amphetamine addiction_Homo sapiens_hsa050311.96123937
23Taste transduction_Homo sapiens_hsa047421.95153442
24Nucleotide excision repair_Homo sapiens_hsa034201.94268332
25DNA replication_Homo sapiens_hsa030301.93538698
26Rheumatoid arthritis_Homo sapiens_hsa053231.88287118
27Basal transcription factors_Homo sapiens_hsa030221.85867621
28Glutamatergic synapse_Homo sapiens_hsa047241.80401329
29Long-term potentiation_Homo sapiens_hsa047201.80074614
30Parkinsons disease_Homo sapiens_hsa050121.78843556
31Steroid biosynthesis_Homo sapiens_hsa001001.76655807
32Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.75614320
33Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.75455803
34Dopaminergic synapse_Homo sapiens_hsa047281.75021883
35Serotonergic synapse_Homo sapiens_hsa047261.73527138
36RNA degradation_Homo sapiens_hsa030181.70562548
37Homologous recombination_Homo sapiens_hsa034401.69222133
38One carbon pool by folate_Homo sapiens_hsa006701.65261950
39Type I diabetes mellitus_Homo sapiens_hsa049401.62201383
40Selenocompound metabolism_Homo sapiens_hsa004501.59456509
41Insulin secretion_Homo sapiens_hsa049111.56684522
42Long-term depression_Homo sapiens_hsa047301.56543112
43Fanconi anemia pathway_Homo sapiens_hsa034601.53776376
44Base excision repair_Homo sapiens_hsa034101.51327897
45Alzheimers disease_Homo sapiens_hsa050101.46714569
46Phagosome_Homo sapiens_hsa041451.41782675
47Salivary secretion_Homo sapiens_hsa049701.40610650
48Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.36892463
49Cell cycle_Homo sapiens_hsa041101.36510307
50Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.35843732
51Calcium signaling pathway_Homo sapiens_hsa040201.31960075
52Spliceosome_Homo sapiens_hsa030401.29932123
53Cocaine addiction_Homo sapiens_hsa050301.28197100
54RNA polymerase_Homo sapiens_hsa030201.27878849
55Huntingtons disease_Homo sapiens_hsa050161.26316140
56Renin secretion_Homo sapiens_hsa049241.24441481
57Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.21754495
58mRNA surveillance pathway_Homo sapiens_hsa030151.19857256
59Cholinergic synapse_Homo sapiens_hsa047251.17550712
60Fatty acid metabolism_Homo sapiens_hsa012121.14535138
61Phototransduction_Homo sapiens_hsa047441.05655196
62Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.04574820
63Gastric acid secretion_Homo sapiens_hsa049711.01718591
64Glutathione metabolism_Homo sapiens_hsa004800.99998197
65Fatty acid degradation_Homo sapiens_hsa000710.99761798
66Biosynthesis of amino acids_Homo sapiens_hsa012300.99402731
67Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.98655282
68SNARE interactions in vesicular transport_Homo sapiens_hsa041300.97325692
69Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.96480712
70Cardiac muscle contraction_Homo sapiens_hsa042600.94419554
71Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.94234775
72Primary bile acid biosynthesis_Homo sapiens_hsa001200.93714135
73p53 signaling pathway_Homo sapiens_hsa041150.93692304
74Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.91355176
75Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.90539919
76Peroxisome_Homo sapiens_hsa041460.89900579
77Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.89658012
78Pyruvate metabolism_Homo sapiens_hsa006200.89594345
79Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.89551300
80Purine metabolism_Homo sapiens_hsa002300.88957788
81Aldosterone synthesis and secretion_Homo sapiens_hsa049250.88321703
82Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.86196109
83Oxytocin signaling pathway_Homo sapiens_hsa049210.85996164
84Hippo signaling pathway_Homo sapiens_hsa043900.85891643
85Pentose and glucuronate interconversions_Homo sapiens_hsa000400.83500603
86Folate biosynthesis_Homo sapiens_hsa007900.83370685
87Pyrimidine metabolism_Homo sapiens_hsa002400.83051448
88Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.82465940
89Lysine degradation_Homo sapiens_hsa003100.81012536
90beta-Alanine metabolism_Homo sapiens_hsa004100.80741026
91Sulfur metabolism_Homo sapiens_hsa009200.74097079
92Gap junction_Homo sapiens_hsa045400.73046368
93Caffeine metabolism_Homo sapiens_hsa002320.72851846
94TGF-beta signaling pathway_Homo sapiens_hsa043500.72738945
95cAMP signaling pathway_Homo sapiens_hsa040240.72735290
96Tight junction_Homo sapiens_hsa045300.71489203
97Hedgehog signaling pathway_Homo sapiens_hsa043400.71222283
982-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.71092650
99Phosphatidylinositol signaling system_Homo sapiens_hsa040700.70175771
100Adherens junction_Homo sapiens_hsa045200.67946801
101Tryptophan metabolism_Homo sapiens_hsa003800.66391671
102Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.65883433
103Retinol metabolism_Homo sapiens_hsa008300.64399488
104Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.62215823
105Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.61922756
106Proteasome_Homo sapiens_hsa030500.60729726
107Wnt signaling pathway_Homo sapiens_hsa043100.59524689
108Vascular smooth muscle contraction_Homo sapiens_hsa042700.59485043
109ErbB signaling pathway_Homo sapiens_hsa040120.57610368
110Arginine and proline metabolism_Homo sapiens_hsa003300.56007371
111Butanoate metabolism_Homo sapiens_hsa006500.55962581
112Maturity onset diabetes of the young_Homo sapiens_hsa049500.55958472
113Basal cell carcinoma_Homo sapiens_hsa052170.55921984
114Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.54569178
115GnRH signaling pathway_Homo sapiens_hsa049120.53250478
116Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.52078067
117N-Glycan biosynthesis_Homo sapiens_hsa005100.51733486
118Regulation of autophagy_Homo sapiens_hsa041400.50399477
119cGMP-PKG signaling pathway_Homo sapiens_hsa040220.49721666
120Fatty acid elongation_Homo sapiens_hsa000620.47789032
121Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.47714379
122Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.47635173
123Dilated cardiomyopathy_Homo sapiens_hsa054140.47283485
124Vitamin B6 metabolism_Homo sapiens_hsa007500.46850410
125Type II diabetes mellitus_Homo sapiens_hsa049300.46744295
126Melanogenesis_Homo sapiens_hsa049160.46217609
127Melanoma_Homo sapiens_hsa052180.45930937
128Pentose phosphate pathway_Homo sapiens_hsa000300.45506410
129Axon guidance_Homo sapiens_hsa043600.45363554
130Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.44484791
131MAPK signaling pathway_Homo sapiens_hsa040100.44318078
132Estrogen signaling pathway_Homo sapiens_hsa049150.42233647
133Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.42018365
134Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.40138530
135Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.38995158
136Thyroid hormone synthesis_Homo sapiens_hsa049180.38984166
137Alcoholism_Homo sapiens_hsa050340.38804719
138Ras signaling pathway_Homo sapiens_hsa040140.36113292
139Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.35074984
140Protein export_Homo sapiens_hsa030600.35016861
141Histidine metabolism_Homo sapiens_hsa003400.34501300
142Fructose and mannose metabolism_Homo sapiens_hsa000510.33532435
143Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.33124869
144Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.32686529
145Vitamin digestion and absorption_Homo sapiens_hsa049770.32031401
146Oocyte meiosis_Homo sapiens_hsa041140.30565024
147Ovarian steroidogenesis_Homo sapiens_hsa049130.30445363
148Inositol phosphate metabolism_Homo sapiens_hsa005620.30001128
149Chemical carcinogenesis_Homo sapiens_hsa052040.29541580
150Glucagon signaling pathway_Homo sapiens_hsa049220.29006707
151Galactose metabolism_Homo sapiens_hsa000520.28988493
152Circadian rhythm_Homo sapiens_hsa047100.28938998
153Glioma_Homo sapiens_hsa052140.27314582
154ECM-receptor interaction_Homo sapiens_hsa045120.26202305
155Steroid hormone biosynthesis_Homo sapiens_hsa001400.25828482
156Starch and sucrose metabolism_Homo sapiens_hsa005000.25702474
157Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.25636021
158Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.25584377
159Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.25433261
160Thyroid cancer_Homo sapiens_hsa052160.24463549
161Protein digestion and absorption_Homo sapiens_hsa049740.21982712
162Cysteine and methionine metabolism_Homo sapiens_hsa002700.20282669
163Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.17209146
164Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.16998318
165African trypanosomiasis_Homo sapiens_hsa051430.16689808
166Phenylalanine metabolism_Homo sapiens_hsa003600.15663266
167Pancreatic secretion_Homo sapiens_hsa049720.15044840
168Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.14437247
169Carbon metabolism_Homo sapiens_hsa012000.12937254
170Autoimmune thyroid disease_Homo sapiens_hsa053200.12696837
171Rap1 signaling pathway_Homo sapiens_hsa040150.12512249
172Metabolic pathways_Homo sapiens_hsa011000.11497900

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