IMPAD1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the inositol monophosphatase family. The encoded protein is localized to the Golgi apparatus and catalyzes the hydrolysis of phosphoadenosine phosphate (PAP) to adenosine monophosphate (AMP). Mutations in this gene are a cause of GRAPP type chondrodysplasia with joint dislocations, and a pseudogene of this gene is located on the long arm of chromosome 1. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1central nervous system myelination (GO:0022010)4.74496415
2axon ensheathment in central nervous system (GO:0032291)4.74496415
3COPI coating of Golgi vesicle (GO:0048205)4.38230407
4Golgi transport vesicle coating (GO:0048200)4.38230407
5dendritic spine morphogenesis (GO:0060997)4.03291291
6cell adhesion mediated by integrin (GO:0033627)3.99198799
7neuron cell-cell adhesion (GO:0007158)3.87640231
8presynaptic membrane assembly (GO:0097105)3.83324244
9hemidesmosome assembly (GO:0031581)3.75422730
10axonal fasciculation (GO:0007413)3.66879963
11layer formation in cerebral cortex (GO:0021819)3.64658111
12neuron recognition (GO:0008038)3.62669764
13negative regulation of neurotransmitter secretion (GO:0046929)3.59573496
14myelination (GO:0042552)3.59189636
15maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.56440365
16ensheathment of neurons (GO:0007272)3.56165678
17axon ensheathment (GO:0008366)3.56165678
18limb bud formation (GO:0060174)3.55852406
19skin morphogenesis (GO:0043589)3.54958713
20apical protein localization (GO:0045176)3.54103779
21COPII vesicle coating (GO:0048208)3.51931681
22presynaptic membrane organization (GO:0097090)3.51143262
23asymmetric protein localization (GO:0008105)3.44993731
24protein retention in ER lumen (GO:0006621)3.44053696
25cell-substrate junction assembly (GO:0007044)3.32246900
26negative regulation of neurotransmitter transport (GO:0051589)3.26157614
27dendrite morphogenesis (GO:0048813)3.21122504
28desmosome organization (GO:0002934)3.16229755
29retina vasculature morphogenesis in camera-type eye (GO:0061299)3.15485303
30fatty acid elongation (GO:0030497)3.13182230
31endodermal cell differentiation (GO:0035987)3.12776483
32basement membrane organization (GO:0071711)3.10887335
33cerebral cortex radially oriented cell migration (GO:0021799)3.10579508
34collagen fibril organization (GO:0030199)3.05538195
35regulation of transforming growth factor beta2 production (GO:0032909)3.04745073
36nuclear pore complex assembly (GO:0051292)3.04713347
37locomotory exploration behavior (GO:0035641)3.03088753
38negative regulation of fatty acid transport (GO:2000192)3.01444277
39vesicle coating (GO:0006901)3.00076194
40regulation of axon extension involved in axon guidance (GO:0048841)2.96497246
41negative regulation of axon extension (GO:0030517)2.96194937
42regulation of short-term neuronal synaptic plasticity (GO:0048172)2.94359404
43transmission of nerve impulse (GO:0019226)2.94171562
44paraxial mesoderm development (GO:0048339)2.93126963
45long-chain fatty acid biosynthetic process (GO:0042759)2.86174747
46negative regulation of axon extension involved in axon guidance (GO:0048843)2.86015715
47protein hydroxylation (GO:0018126)2.83821970
48adherens junction assembly (GO:0034333)2.83172546
49cerebellar granule cell differentiation (GO:0021707)2.82568902
50regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.82420170
51chondrocyte proliferation (GO:0035988)2.81360443
52hypotonic response (GO:0006971)2.80843298
53focal adhesion assembly (GO:0048041)2.78929438
54cell-substrate adherens junction assembly (GO:0007045)2.78929438
55regulation of dendritic spine morphogenesis (GO:0061001)2.78315221
56positive regulation of synapse assembly (GO:0051965)2.78079357
57sequestering of extracellular ligand from receptor (GO:0035581)2.78074143
58regulation of axon guidance (GO:1902667)2.77448532
59myelination in peripheral nervous system (GO:0022011)2.77298910
60peripheral nervous system axon ensheathment (GO:0032292)2.77298910
61vocalization behavior (GO:0071625)2.75520654
62vascular endothelial growth factor signaling pathway (GO:0038084)2.73946156
63retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.73867798
64* chondrocyte development (GO:0002063)2.73782747
65peptidyl-proline hydroxylation (GO:0019511)2.73060718
66photoreceptor cell differentiation (GO:0046530)2.73009219
67eye photoreceptor cell differentiation (GO:0001754)2.73009219
68negative regulation of peptidyl-threonine phosphorylation (GO:0010801)2.72848415
69synaptic vesicle maturation (GO:0016188)2.71984139
70dendritic spine organization (GO:0097061)2.67759422
71positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.66355821
72neuronal action potential propagation (GO:0019227)2.64899962
73regulation of synaptic vesicle exocytosis (GO:2000300)2.64170919
74membrane assembly (GO:0071709)2.63849319
75establishment of nucleus localization (GO:0040023)2.62965385
76mesodermal cell differentiation (GO:0048333)2.62714932
77positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.60210479
78negative regulation of axonogenesis (GO:0050771)2.59844121
79epithelial cell-cell adhesion (GO:0090136)2.59402670
80apoptotic cell clearance (GO:0043277)2.58577664
81negative regulation of axon guidance (GO:1902668)2.58482527
82hippo signaling (GO:0035329)2.58396738
83mating behavior (GO:0007617)2.58267564
84regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.58108519
85glutamate secretion (GO:0014047)2.57205400
86synapse organization (GO:0050808)2.57201048
87insulin-like growth factor receptor signaling pathway (GO:0048009)2.56880980
88regulation of glucocorticoid metabolic process (GO:0031943)2.54950555
89regulation of early endosome to late endosome transport (GO:2000641)2.53615169
90neuronal ion channel clustering (GO:0045161)2.53326146
91exploration behavior (GO:0035640)2.53072971
92lateral sprouting from an epithelium (GO:0060601)2.52176076
93synaptic vesicle exocytosis (GO:0016079)2.50051157
94gamma-aminobutyric acid signaling pathway (GO:0007214)2.48466750
95ionotropic glutamate receptor signaling pathway (GO:0035235)2.48257313
96organelle transport along microtubule (GO:0072384)2.48200428
97regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.47983644
98regulation of dendritic spine development (GO:0060998)2.47161514
99embryonic retina morphogenesis in camera-type eye (GO:0060059)2.45918593
100central nervous system projection neuron axonogenesis (GO:0021952)2.45828651
101regulation of low-density lipoprotein particle receptor biosynthetic process (GO:0045714)2.45408656
102positive regulation of osteoblast proliferation (GO:0033690)2.45349890
103myelin maintenance (GO:0043217)2.44896373
104vesicle transport along microtubule (GO:0047496)2.43971500
105nuclear pore organization (GO:0006999)2.43902407
106regulation of glucose import in response to insulin stimulus (GO:2001273)2.43694689
107synapse assembly (GO:0007416)2.43505647
108L-amino acid import (GO:0043092)2.43131518
109protein localization to endosome (GO:0036010)2.42608291
110oligodendrocyte differentiation (GO:0048709)2.41867235
111glutamate receptor signaling pathway (GO:0007215)2.40631250
112protein localization to synapse (GO:0035418)2.40335521
113substrate adhesion-dependent cell spreading (GO:0034446)2.40333970
114positive regulation of endothelial cell apoptotic process (GO:2000353)2.40004281
115postsynaptic membrane organization (GO:0001941)2.39390111
116stress fiber assembly (GO:0043149)2.39372502
117astrocyte development (GO:0014002)2.38294254
118cytoskeletal anchoring at plasma membrane (GO:0007016)2.38257053
119regulation of synapse assembly (GO:0051963)2.37933879
120gamma-aminobutyric acid transport (GO:0015812)2.37518033
121protein localization to microtubule (GO:0035372)2.35281194
122neuron remodeling (GO:0016322)2.35037106
123iron ion import (GO:0097286)2.34680779
124endothelial cell morphogenesis (GO:0001886)2.34613685
125cell migration involved in sprouting angiogenesis (GO:0002042)2.34204761
126regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.33909762
127regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.33887028
128neuromuscular junction development (GO:0007528)2.32476886
129nerve growth factor signaling pathway (GO:0038180)2.31681716
130wound healing, spreading of epidermal cells (GO:0035313)2.31549579
131substantia nigra development (GO:0021762)2.31346669
132bundle of His cell to Purkinje myocyte communication (GO:0086069)2.31013752
133protein heterotrimerization (GO:0070208)2.30413070
134camera-type eye morphogenesis (GO:0048593)2.30184531
135positive regulation of blood vessel endothelial cell migration (GO:0043536)2.30024418
136vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.28371270
137negative regulation of protein localization to plasma membrane (GO:1903077)2.28288566
138activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.27862209
139gap junction assembly (GO:0016264)2.26771681
140embryonic process involved in female pregnancy (GO:0060136)2.25955718
141regulation of steroid hormone biosynthetic process (GO:0090030)2.25149520
142dendrite development (GO:0016358)2.24237118
143regulation of long-term neuronal synaptic plasticity (GO:0048169)2.24190309
144embryonic foregut morphogenesis (GO:0048617)2.23604599
145regulation of dendrite morphogenesis (GO:0048814)2.23377830
146low-density lipoprotein particle clearance (GO:0034383)2.23242513
147regulation of transforming growth factor beta1 production (GO:0032908)2.22703995
148collagen metabolic process (GO:0032963)2.22352253
149regulation of cardioblast differentiation (GO:0051890)2.22028566
150suckling behavior (GO:0001967)2.18351178
151neurotransmitter catabolic process (GO:0042135)2.17736184
152negative regulation of anoikis (GO:2000811)2.17577614
153innervation (GO:0060384)2.17445903
154establishment of mitochondrion localization (GO:0051654)2.17443059
155notochord development (GO:0030903)2.17219301
156neuron-neuron synaptic transmission (GO:0007270)2.16155961
157membrane protein ectodomain proteolysis (GO:0006509)2.16021100
158ephrin receptor signaling pathway (GO:0048013)2.15561207
159regulation of glutamate receptor signaling pathway (GO:1900449)2.15555521
160morphogenesis of an epithelial sheet (GO:0002011)2.15396704
161positive regulation of neurological system process (GO:0031646)2.14636508
162peptidyl-tyrosine autophosphorylation (GO:0038083)2.13913378
163endocardial cushion development (GO:0003197)2.13742533
164negative regulation of catenin import into nucleus (GO:0035414)2.13470244
165dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.13390191
166positive regulation of nuclease activity (GO:0032075)2.13368785
167magnesium ion transport (GO:0015693)2.12847521
168anatomical structure arrangement (GO:0048532)2.12567905
169multicellular organismal macromolecule metabolic process (GO:0044259)2.12489728
170regulation of neuron migration (GO:2001222)2.12145032
171regulation of collateral sprouting (GO:0048670)2.11865636
172cerebral cortex cell migration (GO:0021795)2.11631827
173negative regulation of chondrocyte differentiation (GO:0032331)2.11627207
174regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.10996808
175central nervous system neuron axonogenesis (GO:0021955)2.10826666
176substrate-dependent cell migration (GO:0006929)2.10523479
177positive regulation of glucose import (GO:0046326)2.09296121
178extracellular matrix assembly (GO:0085029)2.08699583
179extracellular matrix disassembly (GO:0022617)2.08619909
180import into cell (GO:0098657)2.08273113
181ER-nucleus signaling pathway (GO:0006984)2.08073438
182endoplasmic reticulum unfolded protein response (GO:0030968)2.07853727
183planar cell polarity pathway involved in neural tube closure (GO:0090179)2.07645336
184regulation of protein localization to plasma membrane (GO:1903076)2.07153076
185collagen catabolic process (GO:0030574)2.07007725
186L-serine transport (GO:0015825)2.06973780
187cortical actin cytoskeleton organization (GO:0030866)2.06959379
188positive regulation of establishment of protein localization to plasma membrane (GO:0090004)2.06630116
189regulation of plasminogen activation (GO:0010755)2.06424392
190regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00432.06403405
191protein localization to cell surface (GO:0034394)2.06091740
192multicellular organismal metabolic process (GO:0044236)2.05249124
193bone trabecula formation (GO:0060346)2.04880253
194regulation of nucleobase-containing compound transport (GO:0032239)2.04669101

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human3.79046421
2NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.58010819
3CLOCK_20551151_ChIP-Seq_293T_Human3.12685030
4GBX2_23144817_ChIP-Seq_PC3_Human2.99394883
5EZH2_22144423_ChIP-Seq_EOC_Human2.98049691
6SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.48352448
7AR_21572438_ChIP-Seq_LNCaP_Human2.44022469
8TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.43913335
9SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.43647553
10JARID2_20064375_ChIP-Seq_MESCs_Mouse2.39685439
11CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.35968537
12SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.33924917
13AR_21909140_ChIP-Seq_LNCAP_Human2.32385944
14EZH2_27304074_Chip-Seq_ESCs_Mouse2.21317426
15RARG_19884340_ChIP-ChIP_MEFs_Mouse2.18204764
16SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.17806036
17FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.17454476
18RNF2_18974828_ChIP-Seq_MESCs_Mouse2.17429138
19EZH2_18974828_ChIP-Seq_MESCs_Mouse2.17429138
20EED_16625203_ChIP-ChIP_MESCs_Mouse2.16084542
21TRIM28_21343339_ChIP-Seq_HEK293_Human2.14603685
22SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.13031042
23SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.08951288
24SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse2.05651940
25TAF15_26573619_Chip-Seq_HEK293_Human2.04157997
26PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.02269805
27EGR1_19374776_ChIP-ChIP_THP-1_Human2.00615627
28WT1_19549856_ChIP-ChIP_CCG9911_Human1.97920376
29MTF2_20144788_ChIP-Seq_MESCs_Mouse1.95106844
30JARID2_20075857_ChIP-Seq_MESCs_Mouse1.94650071
31GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.94379284
32* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.94241058
33ESR2_21235772_ChIP-Seq_MCF-7_Human1.93207737
34CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.92923084
35SALL4_18804426_ChIP-ChIP_XEN_Mouse1.92012427
36POU3F2_20337985_ChIP-ChIP_501MEL_Human1.91043652
37PIAS1_25552417_ChIP-Seq_VCAP_Human1.90985951
38ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.90623124
39CTBP2_25329375_ChIP-Seq_LNCAP_Human1.87851378
40ZNF263_19887448_ChIP-Seq_K562_Human1.86349049
41SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.86264406
42CDX2_19796622_ChIP-Seq_MESCs_Mouse1.83401359
43SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.80894405
44SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.80894405
45SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.80328129
46* TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.78495785
47CTBP1_25329375_ChIP-Seq_LNCAP_Human1.77458685
48FUS_26573619_Chip-Seq_HEK293_Human1.76841397
49RNF2_27304074_Chip-Seq_ESCs_Mouse1.76482435
50SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.76168933
51* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.75903110
52KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.75028358
53BRD4_25478319_ChIP-Seq_HGPS_Human1.74681774
54SOX9_24532713_ChIP-Seq_HFSC_Mouse1.72864729
55ZNF217_24962896_ChIP-Seq_MCF-7_Human1.72845855
56ZFP57_27257070_Chip-Seq_ESCs_Mouse1.71794969
57RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.70135365
58PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.69107813
59PPAR_26484153_Chip-Seq_NCI-H1993_Human1.68845700
60EZH2_27294783_Chip-Seq_ESCs_Mouse1.65040424
61NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.64975016
62P300_19829295_ChIP-Seq_ESCs_Human1.62823359
63HIF1A_21447827_ChIP-Seq_MCF-7_Human1.62571793
64ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.62364071
65* SMAD3_21741376_ChIP-Seq_EPCs_Human1.62167093
66CBX2_27304074_Chip-Seq_ESCs_Mouse1.61281983
67CTNNB1_20460455_ChIP-Seq_HCT116_Human1.60654815
68SUZ12_27294783_Chip-Seq_ESCs_Mouse1.60255161
69* SMAD4_21799915_ChIP-Seq_A2780_Human1.57184132
70AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.56152628
71SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.55722244
72* TBX20_22328084_ChIP-Seq_HEART_Mouse1.54928843
73* TBX20_22080862_ChIP-Seq_HEART_Mouse1.54928843
74P300_27058665_Chip-Seq_ZR-75-30cells_Human1.54165168
75DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.53246719
76ZNF274_21170338_ChIP-Seq_K562_Hela1.53051923
77TP53_16413492_ChIP-PET_HCT116_Human1.50420110
78PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.49691519
79DROSHA_22980978_ChIP-Seq_HELA_Human1.49189069
80PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.49141798
81TP53_18474530_ChIP-ChIP_U2OS_Human1.48921347
82* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.47522571
83TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.47290158
84CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.46659478
85NRF2_20460467_ChIP-Seq_MEFs_Mouse1.43155670
86NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.43155670
87ER_23166858_ChIP-Seq_MCF-7_Human1.41331386
88EP300_21415370_ChIP-Seq_HL-1_Mouse1.40830881
89ESR1_21235772_ChIP-Seq_MCF-7_Human1.39070598
90ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.38856071
91UBF1/2_26484160_Chip-Seq_HMECs_Human1.36370457
92ARNT_22903824_ChIP-Seq_MCF-7_Human1.36078142
93SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.35676682
94SMAD_19615063_ChIP-ChIP_OVARY_Human1.34554717
95TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.33746912
96NFIB_24661679_ChIP-Seq_LUNG_Mouse1.33702729
97TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.33139776
98KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.32564868
99* STAT3_23295773_ChIP-Seq_U87_Human1.31784385
100GATA2_21666600_ChIP-Seq_HMVEC_Human1.30388023
101PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.30231523
102* SOX2_21211035_ChIP-Seq_LN229_Gbm1.29922119
103BMI1_23680149_ChIP-Seq_NPCS_Mouse1.29880586
104AHR_22903824_ChIP-Seq_MCF-7_Human1.29842563
105ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.29691787
106FOXO3_23340844_ChIP-Seq_DLD1_Human1.29043909
107WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.26943860
108PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.25497301
109NR3C1_21868756_ChIP-Seq_MCF10A_Human1.25081896
110FOXA2_19822575_ChIP-Seq_HepG2_Human1.24695471
111NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.22468714
112REST_21632747_ChIP-Seq_MESCs_Mouse1.22250766
113* SOX2_27498859_Chip-Seq_STOMACH_Mouse1.19962523
114RING1B_27294783_Chip-Seq_NPCs_Mouse1.19679783
115* NR3C1_23031785_ChIP-Seq_PC12_Mouse1.19507352
116TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.17779834
117UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.16357693
118TCF4_18268006_ChIP-ChIP_LS174T_Human1.16321003
119RARB_27405468_Chip-Seq_BRAIN_Mouse1.15196275
120ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.14573854
121* RNF2_27304074_Chip-Seq_NSC_Mouse1.13890483
122KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.13664454
123TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.12758052
124WT1_25993318_ChIP-Seq_PODOCYTE_Human1.12592816
125LXR_22158963_ChIP-Seq_LIVER_Mouse1.12333153
126* AR_25329375_ChIP-Seq_VCAP_Human1.11785338
127RUNX2_22187159_ChIP-Seq_PCA_Human1.11632819
128* YAP1_20516196_ChIP-Seq_MESCs_Mouse1.11517959
129TCF4_23295773_ChIP-Seq_U87_Human1.11451621
130EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.10827470
131STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.10207157
132SOX2_20726797_ChIP-Seq_SW620_Human1.10150972
133RXR_22158963_ChIP-Seq_LIVER_Mouse1.10027034
134ISL1_27105846_Chip-Seq_CPCs_Mouse1.09722971
135NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.09702030
136VDR_22108803_ChIP-Seq_LS180_Human1.09479974
137EWS_26573619_Chip-Seq_HEK293_Human1.09150306
138BCAT_22108803_ChIP-Seq_LS180_Human1.08838256
139EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.08811858
140RING1B_27294783_Chip-Seq_ESCs_Mouse1.08118040
141* FOXM1_26456572_ChIP-Seq_MCF-7_Human1.08102220
142Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.06942009
143TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.04854246
144GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04656387
145MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.04462830
146ESR1_20079471_ChIP-ChIP_T-47D_Human1.04365743
147MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.03235327
148KDM2B_26808549_Chip-Seq_K562_Human1.03181314
149AR_19668381_ChIP-Seq_PC3_Human1.02984766
150FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.02667834
151RBPJ_22232070_ChIP-Seq_NCS_Mouse1.02424663
152LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01203520
153SALL1_21062744_ChIP-ChIP_HESCs_Human1.00349220
154ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.00115715
155CJUN_26792858_Chip-Seq_BT549_Human0.99932638
156IGF1R_20145208_ChIP-Seq_DFB_Human0.99431947
157RXR_22108803_ChIP-Seq_LS180_Human0.99242719
158ZFP281_27345836_Chip-Seq_ESCs_Mouse0.98855218
159NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.98574882
160* NANOG_18555785_Chip-Seq_ESCs_Mouse0.98522148
161TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.97938401
162HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.97693367
163JUN_21703547_ChIP-Seq_K562_Human0.96765501
164SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.95927300
165TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.95558802
166HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.92961247
167FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.92277928
168TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.92088451
169PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.88657018
170TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.88353976
171ATF3_27146783_Chip-Seq_COLON_Human0.86891478
172ELK3_25401928_ChIP-Seq_HUVEC_Human0.85626171
173THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.85534381

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003705_abnormal_hypodermis_morpholog4.11129692
2MP0003880_abnormal_central_pattern3.13244238
3MP0003566_abnormal_cell_adhesion2.84876108
4MP0002877_abnormal_melanocyte_morpholog2.77933219
5MP0004859_abnormal_synaptic_plasticity2.65969224
6MP0010352_gastrointestinal_tract_polyps2.62424672
7MP0004270_analgesia2.43902857
8MP0010368_abnormal_lymphatic_system2.37294711
9MP0003941_abnormal_skin_development2.33164923
10MP0001299_abnormal_eye_distance/2.30613886
11MP0000778_abnormal_nervous_system2.24946804
12MP0010234_abnormal_vibrissa_follicle2.23994131
13MP0009780_abnormal_chondrocyte_physiolo2.23162566
14MP0005623_abnormal_meninges_morphology2.19495959
15MP0005171_absent_coat_pigmentation2.15192751
16MP0003635_abnormal_synaptic_transmissio2.15049039
17MP0008438_abnormal_cutaneous_collagen2.11283253
18MP0000920_abnormal_myelination2.09664454
19MP0005257_abnormal_intraocular_pressure2.04655450
20MP0006054_spinal_hemorrhage1.97505449
21MP0003279_aneurysm1.96095309
22MP0000537_abnormal_urethra_morphology1.95570167
23MP0001958_emphysema1.94908093
24MP0003091_abnormal_cell_migration1.90451621
25MP0003122_maternal_imprinting1.90403286
26MP0010678_abnormal_skin_adnexa1.89304639
27MP0004272_abnormal_basement_membrane1.83610652
28MP0002064_seizures1.80308071
29MP0001486_abnormal_startle_reflex1.77871543
30MP0004885_abnormal_endolymph1.77724337
31MP0009745_abnormal_behavioral_response1.77235411
32MP0009046_muscle_twitch1.76843327
33MP0005503_abnormal_tendon_morphology1.74731991
34MP0004185_abnormal_adipocyte_glucose1.71820707
35MP0002063_abnormal_learning/memory/cond1.68032180
36MP0009384_cardiac_valve_regurgitation1.67497829
37MP0004233_abnormal_muscle_weight1.66160746
38MP0002060_abnormal_skin_morphology1.62240184
39MP0005275_abnormal_skin_tensile1.61749724
40MP0002734_abnormal_mechanical_nocicepti1.57663751
41MP0004134_abnormal_chest_morphology1.56963077
42MP0003329_amyloid_beta_deposits1.54540689
43MP0002272_abnormal_nervous_system1.54121126
44MP0005076_abnormal_cell_differentiation1.52204621
45* MP0009250_abnormal_appendicular_skeleto1.50109190
46MP0003136_yellow_coat_color1.49422798
47MP0000733_abnormal_muscle_development1.47348992
48MP0001915_intracranial_hemorrhage1.46728914
49MP0000767_abnormal_smooth_muscle1.46189374
50MP0005023_abnormal_wound_healing1.42879984
51MP0003937_abnormal_limbs/digits/tail_de1.42651786
52MP0000462_abnormal_digestive_system1.41876609
53MP0003868_abnormal_feces_composition1.41606452
54MP0002572_abnormal_emotion/affect_behav1.41167114
55MP0003385_abnormal_body_wall1.40706701
56MP0000013_abnormal_adipose_tissue1.40140156
57MP0001661_extended_life_span1.39393491
58MP0001879_abnormal_lymphatic_vessel1.39058538
59MP0004084_abnormal_cardiac_muscle1.38584517
60MP0000383_abnormal_hair_follicle1.36869228
61MP0003634_abnormal_glial_cell1.36551870
62MP0003690_abnormal_glial_cell1.35232661
63MP0005423_abnormal_somatic_nervous1.33677090
64MP0003283_abnormal_digestive_organ1.32856761
65MP0001440_abnormal_grooming_behavior1.32198408
66MP0000955_abnormal_spinal_cord1.31922147
67MP0005666_abnormal_adipose_tissue1.30544553
68MP0004742_abnormal_vestibular_system1.26556754
69MP0000762_abnormal_tongue_morphology1.24612646
70MP0006138_congestive_heart_failure1.23548397
71MP0005375_adipose_tissue_phenotype1.23532897
72MP0005187_abnormal_penis_morphology1.21969198
73MP0004087_abnormal_muscle_fiber1.21704433
74MP0003191_abnormal_cellular_cholesterol1.20205569
75MP0002282_abnormal_trachea_morphology1.18951935
76MP0003890_abnormal_embryonic-extraembry1.18562378
77MP0002184_abnormal_innervation1.18117771
78MP0002067_abnormal_sensory_capabilities1.18018171
79MP0000759_abnormal_skeletal_muscle1.14442724
80MP0004036_abnormal_muscle_relaxation1.14285672
81MP0002882_abnormal_neuron_morphology1.13929141
82MP0001968_abnormal_touch/_nociception1.13015956
83MP0004924_abnormal_behavior1.12594228
84MP0005386_behavior/neurological_phenoty1.12594228
85MP0004130_abnormal_muscle_cell1.12041805
86MP0003300_gastrointestinal_ulcer1.11525705
87* MP0003755_abnormal_palate_morphology1.09548235
88MP0003453_abnormal_keratinocyte_physiol1.09413122
89MP0002108_abnormal_muscle_morphology1.09202818
90MP0002896_abnormal_bone_mineralization1.06704329
91* MP0001177_atelectasis1.05451617
92MP0003121_genomic_imprinting1.04727186
93MP0002971_abnormal_brown_adipose1.04541660
94MP0000631_abnormal_neuroendocrine_gland1.03407481
95MP0001529_abnormal_vocalization1.03218114
96MP0004145_abnormal_muscle_electrophysio1.03163739
97MP0010630_abnormal_cardiac_muscle1.03032246
98MP0002234_abnormal_pharynx_morphology1.01801596
99MP0002557_abnormal_social/conspecific_i1.01744586
100MP0003632_abnormal_nervous_system1.01467591
101MP0004858_abnormal_nervous_system1.00372614
102MP0000534_abnormal_ureter_morphology0.99515368
103MP0003942_abnormal_urinary_system0.99033895
104MP0002733_abnormal_thermal_nociception0.98135263
105MP0002152_abnormal_brain_morphology0.98124768
106MP0002269_muscular_atrophy0.97731273
107MP0000749_muscle_degeneration0.96876413
108MP0002796_impaired_skin_barrier0.96707279
109MP0002066_abnormal_motor_capabilities/c0.95993394
110MP0002233_abnormal_nose_morphology0.94903291
111MP0001340_abnormal_eyelid_morphology0.94313320
112MP0000647_abnormal_sebaceous_gland0.93583718
113MP0001485_abnormal_pinna_reflex0.93008268
114MP0003950_abnormal_plasma_membrane0.92068357
115MP0008569_lethality_at_weaning0.91738398
116MP0005330_cardiomyopathy0.88614179
117MP0005451_abnormal_body_composition0.88170774
118MP0001970_abnormal_pain_threshold0.88139638
119MP0002128_abnormal_blood_circulation0.85957971
120MP0006276_abnormal_autonomic_nervous0.84728720
121MP0003861_abnormal_nervous_system0.84626270
122MP0002086_abnormal_extraembryonic_tissu0.83969213
123MP0005197_abnormal_uvea_morphology0.82701357
124MP0000467_abnormal_esophagus_morphology0.82545914
125MP0002295_abnormal_pulmonary_circulatio0.81594356
126MP0002925_abnormal_cardiovascular_devel0.81082493
127MP0003935_abnormal_craniofacial_develop0.81046823
128MP0000751_myopathy0.81021594
129MP0000003_abnormal_adipose_tissue0.80951871
130MP0006072_abnormal_retinal_apoptosis0.80782752
131MP0004811_abnormal_neuron_physiology0.80485369
132MP0005248_abnormal_Harderian_gland0.79584664
133MP0002116_abnormal_craniofacial_bone0.79127459
134MP0003984_embryonic_growth_retardation0.78886429
135MP0001849_ear_inflammation0.78862706
136MP0000747_muscle_weakness0.78657902
137MP0002938_white_spotting0.78327379
138MP0002009_preneoplasia0.78306945
139MP0005508_abnormal_skeleton_morphology0.77731782
140MP0001614_abnormal_blood_vessel0.77703919
141MP0010030_abnormal_orbit_morphology0.77042080
142MP0000428_abnormal_craniofacial_morphol0.76976562
143MP0004142_abnormal_muscle_tone0.76436150
144MP0005409_darkened_coat_color0.76391508
145* MP0001943_abnormal_respiration0.76309850
146MP0002697_abnormal_eye_size0.76299937
147MP0002088_abnormal_embryonic_growth/wei0.75678147
148MP0003828_pulmonary_edema0.75100161
149MP0003115_abnormal_respiratory_system0.74799003
150MP0002752_abnormal_somatic_nervous0.74542717
151MP0009053_abnormal_anal_canal0.74471694
152* MP0000432_abnormal_head_morphology0.73920855
153* MP0000163_abnormal_cartilage_morphology0.73866053
154MP0005645_abnormal_hypothalamus_physiol0.73745623
155MP0000579_abnormal_nail_morphology0.72839499
156MP0003787_abnormal_imprinting0.72562132
157MP0005165_increased_susceptibility_to0.70913102
158MP0002084_abnormal_developmental_patter0.69839726
159MP0005380_embryogenesis_phenotype0.67452842
160MP0001672_abnormal_embryogenesis/_devel0.67452842
161MP0005058_abnormal_lysosome_morphology0.67222618
162MP0005621_abnormal_cell_physiology0.67096879
163MP0002089_abnormal_postnatal_growth/wei0.66854443
164MP0009672_abnormal_birth_weight0.66652771
165MP0005670_abnormal_white_adipose0.65910835

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)4.87927623
2Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)3.88208320
3Degeneration of the lateral corticospinal tracts (HP:0002314)3.88208320
4Insidious onset (HP:0003587)3.63519513
5Termporal pattern (HP:0011008)3.63519513
6Aortic dissection (HP:0002647)3.45051612
7Neurofibrillary tangles (HP:0002185)3.37640017
8Abnormality of the corticospinal tract (HP:0002492)3.31859634
9Cerebral inclusion bodies (HP:0100314)3.05723743
10Epiphyseal dysplasia (HP:0002656)2.99358258
11Aortic aneurysm (HP:0004942)2.88212769
12Buphthalmos (HP:0000557)2.80416656
13Type 1 muscle fiber predominance (HP:0003803)2.76027382
14Aplasia involving bones of the extremities (HP:0009825)2.73852294
15Aplasia involving bones of the upper limbs (HP:0009823)2.73852294
16Aplasia of the phalanges of the hand (HP:0009802)2.73852294
17Osteolytic defects of the hand bones (HP:0009699)2.72437930
18Osteolytic defects of the phalanges of the hand (HP:0009771)2.72437930
19Spinal rigidity (HP:0003306)2.71301621
20Focal motor seizures (HP:0011153)2.65754701
21Ankle contracture (HP:0006466)2.65099564
22Fragile skin (HP:0001030)2.63789516
23Vertebral compression fractures (HP:0002953)2.57096830
24Cerebral aneurysm (HP:0004944)2.55017278
25Mitral valve prolapse (HP:0001634)2.54928484
26Bladder diverticulum (HP:0000015)2.51102565
27Mitral stenosis (HP:0001718)2.49444731
28Increased variability in muscle fiber diameter (HP:0003557)2.49346904
29Soft skin (HP:0000977)2.47919220
30Atonic seizures (HP:0010819)2.42438361
31Infantile muscular hypotonia (HP:0008947)2.41293092
32Focal seizures (HP:0007359)2.35141909
33Megalencephaly (HP:0001355)2.31714475
34Right ventricular cardiomyopathy (HP:0011663)2.29589852
35Mildly elevated creatine phosphokinase (HP:0008180)2.28791988
36Hypoplastic ischia (HP:0003175)2.26761146
37Premature rupture of membranes (HP:0001788)2.26612206
38Syringomyelia (HP:0003396)2.26090098
39Spinal cord lesions (HP:0100561)2.26090098
40Intention tremor (HP:0002080)2.25575157
41Abnormality of skeletal muscle fiber size (HP:0012084)2.25083430
42Asymmetry of the thorax (HP:0001555)2.22714565
43Hyperextensible skin (HP:0000974)2.22351630
44Short nail (HP:0001799)2.21960113
45Alacrima (HP:0000522)2.21164215
46Dilatation of the ascending aorta (HP:0005111)2.21148650
47Macroorchidism (HP:0000053)2.21028480
48Blue sclerae (HP:0000592)2.19941306
49Sensory axonal neuropathy (HP:0003390)2.19536629
50Ulnar bowing (HP:0003031)2.16937802
51Akinesia (HP:0002304)2.16848927
52Flat acetabular roof (HP:0003180)2.16147952
53Supranuclear gaze palsy (HP:0000605)2.12435713
54Relative macrocephaly (HP:0004482)2.11552443
55Cervical subluxation (HP:0003308)2.10920154
56Back pain (HP:0003418)2.09791957
57Bell-shaped thorax (HP:0001591)2.09581902
58Abnormality of carpal bone ossification (HP:0006257)2.07952089
59Abnormality of the ischium (HP:0003174)2.07803593
60Excessive salivation (HP:0003781)2.07502060
61Drooling (HP:0002307)2.07502060
62Blue irides (HP:0000635)2.04902341
63Action tremor (HP:0002345)2.04013642
64Overgrowth (HP:0001548)2.03955456
65Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.03661366
66Abnormality of the 2nd finger (HP:0004100)2.03405551
67Vertebral arch anomaly (HP:0008438)2.03183035
68Elbow flexion contracture (HP:0002987)2.01357778
69Abnormality of the acetabulum (HP:0003170)2.01266284
70Increased connective tissue (HP:0009025)2.00896062
71Follicular hyperkeratosis (HP:0007502)2.00771575
72Broad-based gait (HP:0002136)1.99309941
73Arterial tortuosity (HP:0005116)1.99303809
74Abnormal delivery (HP:0001787)1.99105104
75Scapular winging (HP:0003691)1.98448204
76Mitral regurgitation (HP:0001653)1.98328504
77Aqueductal stenosis (HP:0002410)1.95715047
78Spastic gait (HP:0002064)1.95298447
79Scanning speech (HP:0002168)1.94881135
80Aneurysm (HP:0002617)1.94877958
81Cardiovascular calcification (HP:0011915)1.93791402
82Mild short stature (HP:0003502)1.92396380
83Parakeratosis (HP:0001036)1.92082247
84Vascular tortuosity (HP:0004948)1.91940108
85Advanced eruption of teeth (HP:0006288)1.91108384
86Retinal dysplasia (HP:0007973)1.91092227
87Epileptic encephalopathy (HP:0200134)1.91024604
88Papillary thyroid carcinoma (HP:0002895)1.90665750
89Abnormal ossification of hand bones (HP:0005921)1.90144558
90Bronchomalacia (HP:0002780)1.89707387
91Hypoplastic pelvis (HP:0008839)1.89622908
92Mixed hearing impairment (HP:0000410)1.89084992
93Broad metatarsal (HP:0001783)1.88412821
94Shallow orbits (HP:0000586)1.87584233
95Abnormality of the phalanges of the 2nd finger (HP:0009541)1.86627898
96Thickened helices (HP:0000391)1.85434033
97Hyperventilation (HP:0002883)1.85042075
98Hypoplasia of the iris (HP:0007676)1.84782800
99Anteriorly placed anus (HP:0001545)1.83474329
100Joint laxity (HP:0001388)1.82071944
101Knee flexion contracture (HP:0006380)1.81285544
102Genu recurvatum (HP:0002816)1.81258247
103Peripheral hypomyelination (HP:0007182)1.79567919
104Neonatal short-limb short stature (HP:0008921)1.78905918
105Hyporeflexia of lower limbs (HP:0002600)1.77851311
106Decreased lacrimation (HP:0000633)1.77639625
107Vitreoretinal degeneration (HP:0000655)1.77578583
108Abnormal ciliary motility (HP:0012262)1.76248166
109Abnormal auditory evoked potentials (HP:0006958)1.74659273
110Progressive cerebellar ataxia (HP:0002073)1.73985157
111Absence seizures (HP:0002121)1.73830467
112Dysmetria (HP:0001310)1.73632785
113Pheochromocytoma (HP:0002666)1.72788123
114Abnormality of the middle phalanges of the toes (HP:0010183)1.72378405
115Deep venous thrombosis (HP:0002625)1.71705048
116Congenital glaucoma (HP:0001087)1.71444079
117Dysdiadochokinesis (HP:0002075)1.70012624
118Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.69615766
119Abnormality of incisor morphology (HP:0011063)1.69030213
120Disproportionate tall stature (HP:0001519)1.68172914
121Hammertoe (HP:0001765)1.68100961
122Coxa vara (HP:0002812)1.68048524
123Pterygium (HP:0001059)1.67725041
124Wide anterior fontanel (HP:0000260)1.67468674
125Papilledema (HP:0001085)1.67410876
126Natal tooth (HP:0000695)1.67355326
127Abnormality of dentin (HP:0010299)1.67134035
128Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.66466148
129Nemaline bodies (HP:0003798)1.65941171
130Lower limb muscle weakness (HP:0007340)1.65911168
131Distal lower limb amyotrophy (HP:0008944)1.65282027
132Abnormality of the common coagulation pathway (HP:0010990)1.65079267
133Round ear (HP:0100830)1.64973797
134Humeroradial synostosis (HP:0003041)1.63868011
135Synostosis involving the elbow (HP:0003938)1.63868011
136Microglossia (HP:0000171)1.63189855
137Myokymia (HP:0002411)1.62242790
138Abnormal hand bone ossification (HP:0010660)1.61653492
139Slender build (HP:0001533)1.61449364
140Hypoalphalipoproteinemia (HP:0003233)1.61317276
141Thin bony cortex (HP:0002753)1.61011235
142Dialeptic seizures (HP:0011146)1.61002455
143Ankle clonus (HP:0011448)1.60828319
144Visual hallucinations (HP:0002367)1.60739608
145Clumsiness (HP:0002312)1.60517012
146Spondylolisthesis (HP:0003302)1.60516951
147Missing ribs (HP:0000921)1.60500698
148Myelomeningocele (HP:0002475)1.60472095
149Agitation (HP:0000713)1.60355077
150Cutaneous finger syndactyly (HP:0010554)1.60035933
151Broad ribs (HP:0000885)1.59631359
152Absent speech (HP:0001344)1.59577990
153Spinal cord compression (HP:0002176)1.59002227
154Bowel diverticulosis (HP:0005222)1.58945159
155Widely spaced teeth (HP:0000687)1.58499450
156Tetraparesis (HP:0002273)1.58434185
157Atrophic scars (HP:0001075)1.58387552
158* Ankyloglossia (HP:0010296)1.58215938
159Hepatoblastoma (HP:0002884)1.57680441
160Lower limb amyotrophy (HP:0007210)1.57296505
161Muscle fiber inclusion bodies (HP:0100299)1.57287091
162Breech presentation (HP:0001623)1.56836936
163Cupped ribs (HP:0000887)1.56421828
164Type II lissencephaly (HP:0007260)1.56369054
165Truncal ataxia (HP:0002078)1.56094987
166Deep philtrum (HP:0002002)1.55921875
167Exercise-induced myalgia (HP:0003738)1.55903929
168Urinary urgency (HP:0000012)1.55902917
169Absent frontal sinuses (HP:0002688)1.55045002
170Hyperthyroidism (HP:0000836)1.54953541
171Exotropia (HP:0000577)1.53799633
172Severe Myopia (HP:0011003)1.53777226
173Delayed epiphyseal ossification (HP:0002663)1.53222990
174Urinary bladder sphincter dysfunction (HP:0002839)1.53057891
175Wormian bones (HP:0002645)1.52970040
176Exostoses (HP:0100777)1.52904178
177Pulmonic stenosis (HP:0001642)1.52617901
178Abnormality of the distal phalanx of the thumb (HP:0009617)1.52146227
179Vascular calcification (HP:0004934)1.52041912
180Cubitus valgus (HP:0002967)1.51434232
181Achilles tendon contracture (HP:0001771)1.51369959
182Rhizomelia (HP:0008905)1.51234333
183* Coronal craniosynostosis (HP:0004440)1.51233335
184Hyperacusis (HP:0010780)1.51111135
185Delayed cranial suture closure (HP:0000270)1.50911303

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK393.90277402
2FGFR22.92314185
3MARK12.82891494
4OXSR12.67973627
5TRIB32.64275700
6AKT32.41846847
7EEF2K2.28912630
8NTRK32.21188056
9DDR22.19664592
10BCR2.18677498
11RIPK12.14564680
12FRK2.14335992
13CDK122.10607492
14NTRK12.00892169
15PNCK1.94508788
16PKN21.90557554
17CASK1.86929622
18PAK31.86498704
19EPHA41.76948118
20NEK91.72821654
21MAP3K41.64575895
22WNK41.62816882
23MAP3K91.62572237
24PAK61.57814668
25PLK21.57193640
26MET1.56091861
27NTRK21.55394739
28MAP3K21.52181109
29TYRO31.51196459
30WNK11.50276120
31TNIK1.48964128
32ERBB31.47742916
33UHMK11.46867522
34MINK11.43031100
35SIK11.36982208
36MYLK1.36411424
37KSR11.33982072
38CSNK1G21.32059764
39FER1.31364789
40CSNK1A1L1.28142306
41PKN11.28017044
42TRPM71.26039775
43LIMK11.25828174
44PDGFRA1.25254954
45LATS11.24535510
46MAP2K41.24095723
47MOS1.23226607
48CSNK1G31.16655004
49PIK3CA1.12769806
50NEK61.12458791
51EPHB11.11784689
52ROCK21.11125619
53ERBB41.10791071
54FGFR41.09612353
55MTOR1.09010603
56EPHA21.09008130
57FLT31.08566382
58CDK51.06258886
59CSNK1G11.04407673
60OBSCN1.03674103
61TGFBR21.03519551
62MAPK131.02848510
63PAK41.02631816
64EPHB21.01540653
65PRPF4B0.98411946
66BRD40.97809315
67KSR20.96080233
68CDK140.95578356
69PHKG10.94753732
70PHKG20.94753732
71ERN10.94507278
72CAMK2B0.94368870
73CAMK1D0.93163932
74FGFR30.92948528
75SGK30.92443038
76CDK60.92134111
77ICK0.91658830
78RET0.91232732
79STK380.90157974
80CDK190.90010675
81PDGFRB0.88011560
82IRAK30.87801568
83FGR0.87680831
84CAMK1G0.86635798
85CAMK2A0.86219932
86DMPK0.85890166
87CAMK2D0.84505912
88PRKCE0.83732750
89FGFR10.83676203
90STK30.82957619
91MAP2K70.80248778
92ROCK10.80168479
93CDK180.79882121
94CDK150.79862311
95ARAF0.79762803
96SGK2230.79202691
97SGK4940.79202691
98MAP3K130.75800088
99STK38L0.75477834
100STK100.74587347
101PRKD30.72290544
102LATS20.71461258
103YES10.70665653
104EIF2AK10.69521336
105BMPR1B0.69257628
106LRRK20.66705457
107TESK10.66552298
108MST40.66313934
109MAPKAPK50.65920098
110LMTK20.65109285
111CDK11A0.64439432
112WNK30.63298111
113IRAK20.62541353
114PBK0.62225863
115MAP2K10.62156872
116PAK20.61602590
117STK240.59679955
118MAP3K80.59434732
119TTN0.59248791
120MAP3K120.58058824
121SGK20.57520092
122DYRK1A0.57258469
123SGK10.56417932
124MAP3K60.55979241
125STK110.55358365
126FYN0.54158129
127CSNK1D0.54121605
128SCYL20.53712099
129ILK0.53641274
130DYRK20.53170591
131PRKAA20.53138516
132PTK20.52747656
133GSK3A0.52179612
134PRKCH0.49299065
135PIK3CG0.48819113
136PDPK10.48665433
137RAF10.48329535
138MAPK100.46976126
139EIF2AK30.46688989
140MST1R0.46482405
141MAP3K100.46387173
142PRKCG0.45381036
143BRAF0.45106692
144MELK0.42898387
145PTK60.42205972
146CAMKK10.41964991
147NEK10.41885873
148INSR0.41542766
149ADRBK10.41211412
150PRKCQ0.40997130
151CSNK1E0.40771954
152RPS6KB20.40751419
153RPS6KA20.38615498
154AKT20.38449030
155TIE10.38385660

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050332.24174628
2Axon guidance_Homo sapiens_hsa043602.22858530
3Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.21743577
4Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.03262843
5GABAergic synapse_Homo sapiens_hsa047272.00929016
6Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.83505978
7Glutamatergic synapse_Homo sapiens_hsa047241.82427248
8Steroid biosynthesis_Homo sapiens_hsa001001.77050960
9Long-term depression_Homo sapiens_hsa047301.72818735
10Long-term potentiation_Homo sapiens_hsa047201.65729247
11Serotonergic synapse_Homo sapiens_hsa047261.60310815
12Dorso-ventral axis formation_Homo sapiens_hsa043201.59306706
13Dopaminergic synapse_Homo sapiens_hsa047281.59077965
14Circadian entrainment_Homo sapiens_hsa047131.58770643
15Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.56673093
16Morphine addiction_Homo sapiens_hsa050321.53949992
17Thyroid cancer_Homo sapiens_hsa052161.53789655
18ECM-receptor interaction_Homo sapiens_hsa045121.53498793
19Chronic myeloid leukemia_Homo sapiens_hsa052201.48811772
20Amphetamine addiction_Homo sapiens_hsa050311.44713797
21Small cell lung cancer_Homo sapiens_hsa052221.43982653
22Renin secretion_Homo sapiens_hsa049241.43899800
23Cocaine addiction_Homo sapiens_hsa050301.43325485
24AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.43294785
25Prion diseases_Homo sapiens_hsa050201.41478448
26Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.37503533
27Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.36861556
28Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.35419721
29Gastric acid secretion_Homo sapiens_hsa049711.34537370
30Salivary secretion_Homo sapiens_hsa049701.33581525
31Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.32750670
32Cholinergic synapse_Homo sapiens_hsa047251.32581454
33Renal cell carcinoma_Homo sapiens_hsa052111.32089499
34Synaptic vesicle cycle_Homo sapiens_hsa047211.31877716
35Central carbon metabolism in cancer_Homo sapiens_hsa052301.31781075
36Hedgehog signaling pathway_Homo sapiens_hsa043401.31245754
37Melanogenesis_Homo sapiens_hsa049161.29708850
38Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.29305668
39Pancreatic cancer_Homo sapiens_hsa052121.28378251
40Gap junction_Homo sapiens_hsa045401.27575271
41Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.26305720
42Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.25604428
43Tight junction_Homo sapiens_hsa045301.22834371
44ErbB signaling pathway_Homo sapiens_hsa040121.22047022
45Vibrio cholerae infection_Homo sapiens_hsa051101.20684751
46Insulin secretion_Homo sapiens_hsa049111.20381850
47Thyroid hormone signaling pathway_Homo sapiens_hsa049191.18206242
48Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.17668953
49Oxytocin signaling pathway_Homo sapiens_hsa049211.14106890
50Ether lipid metabolism_Homo sapiens_hsa005651.13512671
51Hippo signaling pathway_Homo sapiens_hsa043901.11756253
52Focal adhesion_Homo sapiens_hsa045101.11278556
53Insulin signaling pathway_Homo sapiens_hsa049101.10550112
54GnRH signaling pathway_Homo sapiens_hsa049121.10419154
55Bladder cancer_Homo sapiens_hsa052191.09914033
56Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.09028716
57Basal cell carcinoma_Homo sapiens_hsa052171.08746968
58Wnt signaling pathway_Homo sapiens_hsa043101.07817070
59Estrogen signaling pathway_Homo sapiens_hsa049151.06547298
60Taste transduction_Homo sapiens_hsa047421.06174560
61Non-small cell lung cancer_Homo sapiens_hsa052231.05450230
62Butanoate metabolism_Homo sapiens_hsa006501.05339334
63Complement and coagulation cascades_Homo sapiens_hsa046101.03925330
64Glioma_Homo sapiens_hsa052141.03224668
65AMPK signaling pathway_Homo sapiens_hsa041521.01807962
66Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.01774974
67Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.01515432
68Fatty acid elongation_Homo sapiens_hsa000621.00744520
69Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.99581999
70Dilated cardiomyopathy_Homo sapiens_hsa054140.98202367
71Olfactory transduction_Homo sapiens_hsa047400.97532500
72Vitamin B6 metabolism_Homo sapiens_hsa007500.96663786
73Pancreatic secretion_Homo sapiens_hsa049720.95860186
74Protein digestion and absorption_Homo sapiens_hsa049740.95255846
75Glycosaminoglycan degradation_Homo sapiens_hsa005310.93518163
76Circadian rhythm_Homo sapiens_hsa047100.92811130
77PPAR signaling pathway_Homo sapiens_hsa033200.92666121
78Aldosterone synthesis and secretion_Homo sapiens_hsa049250.92232962
79Proteoglycans in cancer_Homo sapiens_hsa052050.90957485
80Thyroid hormone synthesis_Homo sapiens_hsa049180.89246968
81Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.88978271
82Vascular smooth muscle contraction_Homo sapiens_hsa042700.88123295
83Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.84331861
84mTOR signaling pathway_Homo sapiens_hsa041500.84230815
85Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.84008306
86Neurotrophin signaling pathway_Homo sapiens_hsa047220.81850139
87cAMP signaling pathway_Homo sapiens_hsa040240.81828855
88Glucagon signaling pathway_Homo sapiens_hsa049220.81268416
89Phospholipase D signaling pathway_Homo sapiens_hsa040720.80958101
90Alcoholism_Homo sapiens_hsa050340.80578299
91Ras signaling pathway_Homo sapiens_hsa040140.79781286
92Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.79422795
93Calcium signaling pathway_Homo sapiens_hsa040200.79154882
94Sphingolipid metabolism_Homo sapiens_hsa006000.79044166
95cGMP-PKG signaling pathway_Homo sapiens_hsa040220.78867124
96Insulin resistance_Homo sapiens_hsa049310.78079547
97Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.78006907
98Pathways in cancer_Homo sapiens_hsa052000.77965483
99Longevity regulating pathway - mammal_Homo sapiens_hsa042110.75840791
100Sphingolipid signaling pathway_Homo sapiens_hsa040710.75450517
101Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.75045581
102Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.74935702
103Type II diabetes mellitus_Homo sapiens_hsa049300.74802327
104Colorectal cancer_Homo sapiens_hsa052100.74629785
105Ovarian steroidogenesis_Homo sapiens_hsa049130.73757490
106TGF-beta signaling pathway_Homo sapiens_hsa043500.73186753
107Collecting duct acid secretion_Homo sapiens_hsa049660.72967246
108N-Glycan biosynthesis_Homo sapiens_hsa005100.72547129
109Lysine degradation_Homo sapiens_hsa003100.72187248
110VEGF signaling pathway_Homo sapiens_hsa043700.72094238
111Choline metabolism in cancer_Homo sapiens_hsa052310.71077846
112Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.70459219
113Bile secretion_Homo sapiens_hsa049760.70215687
114Prolactin signaling pathway_Homo sapiens_hsa049170.70142370
115Adipocytokine signaling pathway_Homo sapiens_hsa049200.69512492
116Fatty acid metabolism_Homo sapiens_hsa012120.68614287
117Adherens junction_Homo sapiens_hsa045200.67355266
118* Inositol phosphate metabolism_Homo sapiens_hsa005620.66759790
119Arginine biosynthesis_Homo sapiens_hsa002200.66162144
120Cardiac muscle contraction_Homo sapiens_hsa042600.65311267
121Melanoma_Homo sapiens_hsa052180.64814393
122Prostate cancer_Homo sapiens_hsa052150.64593931
123Rap1 signaling pathway_Homo sapiens_hsa040150.63301937
1242-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.63164821
125MAPK signaling pathway_Homo sapiens_hsa040100.62996560
126Endometrial cancer_Homo sapiens_hsa052130.62542231
127Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.61628591
128FoxO signaling pathway_Homo sapiens_hsa040680.60326088
129Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.60124464
130Fatty acid biosynthesis_Homo sapiens_hsa000610.59372745
131Regulation of actin cytoskeleton_Homo sapiens_hsa048100.59368738
132MicroRNAs in cancer_Homo sapiens_hsa052060.57441073
133Other glycan degradation_Homo sapiens_hsa005110.56951713
134Leukocyte transendothelial migration_Homo sapiens_hsa046700.55398469
135Protein export_Homo sapiens_hsa030600.55313229
136Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.54299430
137Endocytosis_Homo sapiens_hsa041440.54178513
138PI3K-Akt signaling pathway_Homo sapiens_hsa041510.53991843
139Nitrogen metabolism_Homo sapiens_hsa009100.53598917
140Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.52685889
141Amoebiasis_Homo sapiens_hsa051460.51487684
142Alzheimers disease_Homo sapiens_hsa050100.50242273
143Oocyte meiosis_Homo sapiens_hsa041140.46763637
144Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.45849854
145* Phosphatidylinositol signaling system_Homo sapiens_hsa040700.45395793

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »