IMPDH1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene acts as a homotetramer to regulate cell growth. The encoded protein is an enzyme that catalyzes the synthesis of xanthine monophosphate (XMP) from inosine-5'-monophosphate (IMP). This is the rate-limiting step in the de novo synthesis of guanine nucleotides. Defects in this gene are a cause of retinitis pigmentosa type 10 (RP10). Several transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of rhodopsin mediated signaling pathway (GO:0022400)5.91296989
2rhodopsin mediated signaling pathway (GO:0016056)5.75035334
3Golgi transport vesicle coating (GO:0048200)5.46510870
4COPI coating of Golgi vesicle (GO:0048205)5.46510870
5positive regulation by symbiont of host defense response (GO:0052509)5.44269094
6modulation by symbiont of host defense response (GO:0052031)5.44269094
7modulation by organism of immune response of other organism involved in symbiotic interaction (GO:005.44269094
8modulation by organism of defense response of other organism involved in symbiotic interaction (GO:05.44269094
9positive regulation by organism of defense response of other organism involved in symbiotic interact5.44269094
10modulation by symbiont of host immune response (GO:0052553)5.44269094
11response to peptidoglycan (GO:0032494)5.20599883
12negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.18594322
13negative regulation of cell killing (GO:0031342)5.18594322
14neutrophil activation involved in immune response (GO:0002283)4.86272602
15antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.73648588
16positive regulation of gamma-delta T cell activation (GO:0046645)4.55930247
17retinal cone cell development (GO:0046549)4.48376680
18antigen processing and presentation of endogenous antigen (GO:0019883)4.45518346
19detection of other organism (GO:0098543)4.41871414
20macrophage activation involved in immune response (GO:0002281)4.35313075
21detection of bacterium (GO:0016045)4.28615300
22* GMP metabolic process (GO:0046037)4.28495369
23negative regulation of erythrocyte differentiation (GO:0045647)4.26170465
24photoreceptor cell development (GO:0042461)4.07088946
25negative regulation of interleukin-12 production (GO:0032695)4.06751071
26leukocyte aggregation (GO:0070486)4.04126943
27regulation of translational termination (GO:0006449)3.96478953
28regulation of interferon-beta biosynthetic process (GO:0045357)3.79955956
29detection of external biotic stimulus (GO:0098581)3.79732819
30respiratory burst (GO:0045730)3.67969477
31eye photoreceptor cell development (GO:0042462)3.65417586
32detection of molecule of bacterial origin (GO:0032490)3.65331660
33NADH metabolic process (GO:0006734)3.64739082
34photoreceptor cell maintenance (GO:0045494)3.63702600
35regulation of mast cell degranulation (GO:0043304)3.62794223
36retinal rod cell development (GO:0046548)3.56480535
37regulation of leukocyte degranulation (GO:0043300)3.52357579
38response to host immune response (GO:0052572)3.50206752
39response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.50206752
40cellular extravasation (GO:0045123)3.50000431
41regulation of myeloid leukocyte mediated immunity (GO:0002886)3.45432598
42neutrophil activation (GO:0042119)3.45340047
43activation of signaling protein activity involved in unfolded protein response (GO:0006987)3.43736757
44positive regulation of nuclease activity (GO:0032075)3.43074117
45maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.39828011
46protein retention in ER lumen (GO:0006621)3.36438068
47detection of biotic stimulus (GO:0009595)3.35527646
48DNA deamination (GO:0045006)3.34501301
49response to muramyl dipeptide (GO:0032495)3.33135986
50response to host (GO:0075136)3.31830757
51response to host defenses (GO:0052200)3.31830757
52response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.31830757
53formation of translation preinitiation complex (GO:0001731)3.29695391
54lipopolysaccharide-mediated signaling pathway (GO:0031663)3.28249514
55protein insertion into membrane (GO:0051205)3.27553401
56leukocyte migration involved in inflammatory response (GO:0002523)3.27477496
57granulocyte activation (GO:0036230)3.27125994
58phototransduction (GO:0007602)3.24634967
59immunoglobulin mediated immune response (GO:0016064)3.24594758
60CDP-diacylglycerol metabolic process (GO:0046341)3.23574548
61adaptation of signaling pathway (GO:0023058)3.21268562
62regulation of mast cell activation involved in immune response (GO:0033006)3.18786816
63positive regulation of histone deacetylation (GO:0031065)3.18734249
64pentose-phosphate shunt (GO:0006098)3.17592926
65positive regulation of Cdc42 GTPase activity (GO:0043089)3.17168530
66regulation of nuclease activity (GO:0032069)3.14036483
67negative regulation of cell size (GO:0045792)3.13364246
68regulation of translational fidelity (GO:0006450)3.12739366
69phototransduction, visible light (GO:0007603)3.11129319
70positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.10031202
71negative regulation of lymphocyte mediated immunity (GO:0002707)3.09840807
72positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.09366142
73nucleobase biosynthetic process (GO:0046112)3.08506917
74retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.07358173
75regulation of B cell receptor signaling pathway (GO:0050855)3.06510315
76positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.04110155
77myeloid cell activation involved in immune response (GO:0002275)3.03929509
78protein maturation by protein folding (GO:0022417)3.03797704
79positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.03690244
80regulation of gamma-delta T cell activation (GO:0046643)3.03471548
81folic acid-containing compound biosynthetic process (GO:0009396)3.02910363
82cellular response to light stimulus (GO:0071482)3.02430728
83negative regulation of leukocyte mediated immunity (GO:0002704)2.99409156
84regulation of regulated secretory pathway (GO:1903305)2.99071600
85detection of light stimulus (GO:0009583)2.97177191
86regulation of T-helper 2 cell differentiation (GO:0045628)2.96197885
87peptidyl-arginine omega-N-methylation (GO:0035247)2.94704135
88macrophage activation (GO:0042116)2.93892123
89positive regulation of protein deacetylation (GO:0090312)2.93558710
90mannose metabolic process (GO:0006013)2.92548149
91negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.92023177
92NIK/NF-kappaB signaling (GO:0038061)2.90425147
93mitotic G1 DNA damage checkpoint (GO:0031571)2.88556157
94detection of light stimulus involved in sensory perception (GO:0050962)2.88485852
95detection of light stimulus involved in visual perception (GO:0050908)2.88485852
96DNA unwinding involved in DNA replication (GO:0006268)2.87558820
97protein localization to endosome (GO:0036010)2.86016775
98detection of visible light (GO:0009584)2.82959291
99glucose catabolic process (GO:0006007)2.82583821
100regulation of chromatin binding (GO:0035561)2.81346206
101neutrophil mediated immunity (GO:0002446)2.79221660
102regulation of superoxide anion generation (GO:0032928)2.78031718
103purine nucleobase biosynthetic process (GO:0009113)2.77143347
104regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.76143967
105positive regulation of mast cell activation (GO:0033005)2.75749891
106antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.73409822
107antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.73409822
108germinal center formation (GO:0002467)2.72466709
109positive regulation of guanylate cyclase activity (GO:0031284)2.72366294
1103-UTR-mediated mRNA stabilization (GO:0070935)2.71247542
111protein localization to kinetochore (GO:0034501)2.70974766
112negative regulation of innate immune response (GO:0045824)2.70334203
113endoplasmic reticulum unfolded protein response (GO:0030968)2.69525627
114dosage compensation (GO:0007549)2.69202404
115visual perception (GO:0007601)2.68545475
116ribosome assembly (GO:0042255)2.68457802
117pinocytosis (GO:0006907)2.67387885
118response to interleukin-15 (GO:0070672)2.66388751
119regulation of defense response to virus by virus (GO:0050690)2.65677830
120sensory perception of light stimulus (GO:0050953)2.64617173
121protein-chromophore linkage (GO:0018298)2.64297259
122maternal placenta development (GO:0001893)2.63635560
123negative regulation of T cell mediated immunity (GO:0002710)2.62549722
124mitochondrion transport along microtubule (GO:0047497)2.62416230
125establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.62416230
126regulation of guanylate cyclase activity (GO:0031282)2.62194969
127ribosome biogenesis (GO:0042254)2.61710875
128modulation by virus of host process (GO:0019054)2.61706617
129positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557)2.61241513
130cellular response to unfolded protein (GO:0034620)2.60961704
131negative regulation of interleukin-6 production (GO:0032715)2.60579864
132modulation by symbiont of host cellular process (GO:0044068)2.60011628
133regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022352.59510988
134regulation of translational elongation (GO:0006448)2.59105353
135regulation of T cell tolerance induction (GO:0002664)2.58817078
136peptidyl-arginine methylation (GO:0018216)2.58653373
137peptidyl-arginine N-methylation (GO:0035246)2.58653373
138microglial cell activation (GO:0001774)2.58074317
139CDP-diacylglycerol biosynthetic process (GO:0016024)2.57719322
140mitotic nuclear envelope disassembly (GO:0007077)2.56742430
141production of molecular mediator involved in inflammatory response (GO:0002532)2.56498016
142positive thymic T cell selection (GO:0045059)2.56364670
143negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.55997898
144NADPH regeneration (GO:0006740)2.55342004
145negative regulation of toll-like receptor signaling pathway (GO:0034122)2.55156288
146regulation of NFAT protein import into nucleus (GO:0051532)2.54935079
147regulation of mast cell activation (GO:0033003)2.54745652
148response to laminar fluid shear stress (GO:0034616)2.54537460
149nuclear envelope disassembly (GO:0051081)2.54512221
150membrane disassembly (GO:0030397)2.54512221
151type I interferon signaling pathway (GO:0060337)2.53857660
152cellular response to type I interferon (GO:0071357)2.53857660
153folic acid metabolic process (GO:0046655)2.53741980
154leukocyte degranulation (GO:0043299)2.53419754
155negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.53079573
156negative regulation of histone methylation (GO:0031061)2.52445598
157response to type I interferon (GO:0034340)2.52267712
158cellular response to topologically incorrect protein (GO:0035967)2.52099080
159B cell receptor signaling pathway (GO:0050853)2.51226309
160apoptotic process involved in morphogenesis (GO:0060561)2.50192362
161negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.50020535
162regulation of gamma-delta T cell differentiation (GO:0045586)2.49875723
163negative regulation of RNA splicing (GO:0033119)2.49787191
164negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.49325838
165sensory perception of smell (GO:0007608)2.49128960
166regulation of dendritic cell antigen processing and presentation (GO:0002604)2.48744092
167white fat cell differentiation (GO:0050872)2.48363214
168positive regulation of mast cell activation involved in immune response (GO:0033008)2.48354036
169positive regulation of mast cell degranulation (GO:0043306)2.48354036
170positive regulation of B cell differentiation (GO:0045579)2.48247244
171IMP biosynthetic process (GO:0006188)2.48007302
172negative regulation of phagocytosis (GO:0050765)2.47545278
173retina development in camera-type eye (GO:0060041)2.47445958
174negative regulation of cytokine production involved in immune response (GO:0002719)2.46903298
175nucleosome disassembly (GO:0006337)2.46223002
176protein-DNA complex disassembly (GO:0032986)2.46223002
177intracellular estrogen receptor signaling pathway (GO:0030520)2.46175783
178positive regulation of regulated secretory pathway (GO:1903307)2.45866024
179DNA strand elongation involved in DNA replication (GO:0006271)2.45656272
180negative regulation of type 2 immune response (GO:0002829)2.44593437
181mitotic G1/S transition checkpoint (GO:0044819)2.43845771
182ER-nucleus signaling pathway (GO:0006984)2.43261094
183negative regulation of glycoprotein biosynthetic process (GO:0010561)2.42197782
184translesion synthesis (GO:0019985)2.41393706
185vesicle coating (GO:0006901)2.41265899
186antigen processing and presentation via MHC class Ib (GO:0002475)2.39399901
187morphogenesis of an endothelium (GO:0003159)2.38536711
188endothelial tube morphogenesis (GO:0061154)2.38536711
189regulation of translation in response to stress (GO:0043555)2.37703479
190GDP-mannose metabolic process (GO:0019673)2.35863661
191nuclear envelope organization (GO:0006998)2.34067520
192negative regulation of mRNA metabolic process (GO:1903312)2.33015969
193cytokinetic process (GO:0032506)2.32915859
194histone arginine methylation (GO:0034969)2.32440943
195regulation of protein heterodimerization activity (GO:0043497)2.30179227

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human4.13107239
2MYC_22102868_ChIP-Seq_BL_Human3.64721588
3EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.47365734
4MYC_18555785_ChIP-Seq_MESCs_Mouse2.61949843
5VDR_21846776_ChIP-Seq_THP-1_Human2.42911047
6EGR1_19374776_ChIP-ChIP_THP-1_Human2.34436740
7BP1_19119308_ChIP-ChIP_Hs578T_Human2.23583123
8FOXM1_23109430_ChIP-Seq_U2OS_Human2.20213733
9THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.19278654
10ZNF263_19887448_ChIP-Seq_K562_Human2.15646061
11CIITA_25753668_ChIP-Seq_RAJI_Human2.12844568
12PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.03561064
13MYC_19079543_ChIP-ChIP_MESCs_Mouse2.01736583
14IRF8_22096565_ChIP-ChIP_GC-B_Human2.01726833
15* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.93821354
16ETS1_20019798_ChIP-Seq_JURKAT_Human1.90369425
17* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.88398110
18NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.88142406
19RUNX1_22412390_ChIP-Seq_EML_Mouse1.83971650
20KDM2B_26808549_Chip-Seq_DND41_Human1.82899891
21* TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.81967418
22BRD4_27068464_Chip-Seq_AML-cells_Mouse1.81137257
23JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.81097096
24SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.79305051
25RARG_19884340_ChIP-ChIP_MEFs_Mouse1.79238183
26IRF8_21731497_ChIP-ChIP_J774_Mouse1.78789509
27XRN2_22483619_ChIP-Seq_HELA_Human1.78719375
28NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.78656020
29TP63_17297297_ChIP-ChIP_HaCaT_Human1.77766360
30SPI1_23547873_ChIP-Seq_NB4_Human1.76750160
31* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.75635187
32DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.73811571
33SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.72130447
34* MYB_21317192_ChIP-Seq_ERMYB_Mouse1.69439439
35* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.68534614
36GABP_19822575_ChIP-Seq_HepG2_Human1.68285733
37* ELK3_25401928_ChIP-Seq_HUVEC_Human1.67593635
38NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.65351838
39* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.64691796
40TCF7_22412390_ChIP-Seq_EML_Mouse1.64552790
41* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.62044424
42CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.60786273
43CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.56400910
44UTX_26944678_Chip-Seq_JUKART_Human1.56322392
45SPI1_23127762_ChIP-Seq_K562_Human1.55990258
46KLF4_18555785_ChIP-Seq_MESCs_Mouse1.54094929
47TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.52352987
48* LXR_22292898_ChIP-Seq_THP-1_Human1.52101094
49HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.51744069
50* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.50921799
51STAT4_19710469_ChIP-ChIP_TH1__Mouse1.49869554
52DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.49627082
53CREB1_15753290_ChIP-ChIP_HEK293T_Human1.48182555
54NELFA_20434984_ChIP-Seq_ESCs_Mouse1.47031039
55MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.45848658
56TET1_21451524_ChIP-Seq_MESCs_Mouse1.45585061
57SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.43835980
58CTCF_27219007_Chip-Seq_ERYTHROID_Human1.43780875
59SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.43440506
60TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.43424809
61IRF8_27001747_Chip-Seq_BMDM_Mouse1.42953252
62P68_20966046_ChIP-Seq_HELA_Human1.42267187
63E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.40710924
64SA1_27219007_Chip-Seq_ERYTHROID_Human1.40467998
65TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.39930510
66PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.38041432
67VDR_23849224_ChIP-Seq_CD4+_Human1.37082652
68POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.36441328
69THAP11_20581084_ChIP-Seq_MESCs_Mouse1.36322058
70KDM5A_27292631_Chip-Seq_BREAST_Human1.36160013
71GATA1_22383799_ChIP-Seq_G1ME_Mouse1.35814231
72ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.35364837
73MAF_26560356_Chip-Seq_TH1_Human1.34602038
74SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.34213534
75EST1_17652178_ChIP-ChIP_JURKAT_Human1.34131650
76MYCN_18555785_ChIP-Seq_MESCs_Mouse1.32710984
77FOXP3_21729870_ChIP-Seq_TREG_Human1.32598376
78TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.31656622
79FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.31537472
80CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.30984452
81E2F4_17652178_ChIP-ChIP_JURKAT_Human1.30855535
82PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.30193250
83* KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.30143898
84POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.29328417
85STAT6_21828071_ChIP-Seq_BEAS2B_Human1.28609553
86ATF3_27146783_Chip-Seq_COLON_Human1.28073386
87BCL6_27268052_Chip-Seq_Bcells_Human1.27883053
88GABP_17652178_ChIP-ChIP_JURKAT_Human1.27249179
89* PU.1_20513432_ChIP-Seq_Bcells_Mouse1.26921329
90ELF1_17652178_ChIP-ChIP_JURKAT_Human1.26560505
91CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.24400195
92TFEB_21752829_ChIP-Seq_HELA_Human1.23602208
93SRY_22984422_ChIP-ChIP_TESTIS_Rat1.22822023
94PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.22349204
95* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.21952913
96ZFP281_18757296_ChIP-ChIP_E14_Mouse1.21326319
97ELF1_20517297_ChIP-Seq_JURKAT_Human1.21067632
98SCL_19346495_ChIP-Seq_HPC-7_Human1.20656851
99KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.20605818
100DCP1A_22483619_ChIP-Seq_HELA_Human1.20509765
101UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.20014336
102MAF_26560356_Chip-Seq_TH2_Human1.19524744
103E2F1_21310950_ChIP-Seq_MCF-7_Human1.19492493
104NANOG_18555785_ChIP-Seq_MESCs_Mouse1.19210604
105* RACK7_27058665_Chip-Seq_MCF-7_Human1.17766888
106E2F1_18555785_ChIP-Seq_MESCs_Mouse1.16985780
107GATA1_19941827_ChIP-Seq_MEL_Mouse1.16024160
108NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.15974504
109GATA2_22383799_ChIP-Seq_G1ME_Mouse1.15921234
110RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.14806004
111VDR_24763502_ChIP-Seq_THP-1_Human1.13880558
112TTF2_22483619_ChIP-Seq_HELA_Human1.13873865
113FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.13867635
114* MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.13748506
115PHF8_20622854_ChIP-Seq_HELA_Human1.13221023
116MYB_26560356_Chip-Seq_TH1_Human1.13131437
117KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.13113904
118RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.10880161
119FOXP1_21924763_ChIP-Seq_HESCs_Human1.10548677
120* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.09760272
121SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.09318306
122RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.08225795
123CTCF_26484167_Chip-Seq_Bcells_Mouse1.07910196
124MYB_26560356_Chip-Seq_TH2_Human1.06950914
125NCOR1_26117541_ChIP-Seq_K562_Human1.06885203
126YY1_22570637_ChIP-Seq_MALME-3M_Human1.06616939
127STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.06528116
128STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.06516129
129TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.06263303
130BCOR_27268052_Chip-Seq_Bcells_Human1.06062804
131BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.05254767
132EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.04904725
133NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.04751771
134YY1_21170310_ChIP-Seq_MESCs_Mouse1.04520235
135CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.04469597
136FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.03859948
137* KDM2B_26808549_Chip-Seq_K562_Human1.02362549
138CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.01601816
139TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.01191445
140P300_27058665_Chip-Seq_ZR-75-30cells_Human1.00977998
141* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.00731762
142CHD1_26751641_Chip-Seq_LNCaP_Human1.00312336
143* KDM2B_26808549_Chip-Seq_JURKAT_Human0.99452357
144NANOG_21062744_ChIP-ChIP_HESCs_Human0.99426842
145SMC4_20622854_ChIP-Seq_HELA_Human0.99219487
146E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.99008715
147VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.98685756
148* SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.98455281
149CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.98126876
150MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.97276089

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003011_delayed_dark_adaptation4.30261936
2MP0003436_decreased_susceptibility_to3.96989520
3MP0005551_abnormal_eye_electrophysiolog3.77860194
4MP0006072_abnormal_retinal_apoptosis3.43184768
5MP0003724_increased_susceptibility_to3.31440606
6MP0003693_abnormal_embryo_hatching3.26600259
7MP0005253_abnormal_eye_physiology2.94128745
8MP0005451_abnormal_body_composition2.92482366
9MP0008260_abnormal_autophagy2.83394600
10MP0005058_abnormal_lysosome_morphology2.72970056
11MP0001835_abnormal_antigen_presentation2.71156097
12MP0003191_abnormal_cellular_cholesterol2.69201520
13MP0002419_abnormal_innate_immunity2.67850733
14MP0005025_abnormal_response_to2.39253048
15MP0010352_gastrointestinal_tract_polyps2.37117448
16MP0000013_abnormal_adipose_tissue2.35467108
17MP0002877_abnormal_melanocyte_morpholog2.32478440
18MP0002653_abnormal_ependyma_morphology2.26142081
19MP0005000_abnormal_immune_tolerance2.21031014
20MP0000685_abnormal_immune_system2.10621771
21MP0004957_abnormal_blastocyst_morpholog2.08386507
22MP0009785_altered_susceptibility_to2.05417604
23MP0008961_abnormal_basal_metabolism2.02085514
24MP0002396_abnormal_hematopoietic_system2.01174706
25* MP0002420_abnormal_adaptive_immunity1.98520909
26MP0001790_abnormal_immune_system1.98419474
27MP0005387_immune_system_phenotype1.98419474
28* MP0001819_abnormal_immune_cell1.97269064
29MP0003111_abnormal_nucleus_morphology1.97160670
30MP0002723_abnormal_immune_serum1.96963617
31MP0001800_abnormal_humoral_immune1.96553059
32MP0005076_abnormal_cell_differentiation1.95330989
33MP0006082_CNS_inflammation1.94629386
34MP0000003_abnormal_adipose_tissue1.92068584
35MP0002452_abnormal_antigen_presenting1.91645808
36MP0001533_abnormal_skeleton_physiology1.91266676
37MP0009278_abnormal_bone_marrow1.82978645
38MP0004947_skin_inflammation1.81754839
39MP0002148_abnormal_hypersensitivity_rea1.80703014
40MP0005464_abnormal_platelet_physiology1.79497244
41MP0005671_abnormal_response_to1.78821483
42MP0004233_abnormal_muscle_weight1.69971431
43MP0001730_embryonic_growth_arrest1.69808998
44MP0002132_abnormal_respiratory_system1.66611656
45MP0010307_abnormal_tumor_latency1.64670247
46MP0002405_respiratory_system_inflammati1.63189011
47MP0003828_pulmonary_edema1.60443205
48MP0003077_abnormal_cell_cycle1.59883016
49MP0002909_abnormal_adrenal_gland1.59303529
50MP0005670_abnormal_white_adipose1.53329743
51MP0004185_abnormal_adipocyte_glucose1.52403222
52MP0005195_abnormal_posterior_eye1.52309050
53MP0003705_abnormal_hypodermis_morpholog1.51024762
54* MP0000716_abnormal_immune_system1.49114038
55MP0005391_vision/eye_phenotype1.49053212
56MP0004858_abnormal_nervous_system1.48261258
57MP0001986_abnormal_taste_sensitivity1.47885479
58MP0003763_abnormal_thymus_physiology1.47876857
59MP0001545_abnormal_hematopoietic_system1.47199688
60MP0005397_hematopoietic_system_phenotyp1.47199688
61MP0001984_abnormal_olfaction1.47146834
62MP0004130_abnormal_muscle_cell1.46165096
63MP0000350_abnormal_cell_proliferation1.43733460
64MP0010155_abnormal_intestine_physiology1.42705709
65MP0004808_abnormal_hematopoietic_stem1.42583581
66MP0001845_abnormal_inflammatory_respons1.39929081
67MP0003221_abnormal_cardiomyocyte_apopto1.38748484
68MP0003075_altered_response_to1.38354455
69MP0004381_abnormal_hair_follicle1.36684629
70MP0010094_abnormal_chromosome_stability1.36281820
71MP0005394_taste/olfaction_phenotype1.34205604
72MP0005499_abnormal_olfactory_system1.34205604
73MP0005375_adipose_tissue_phenotype1.34166783
74MP0005220_abnormal_exocrine_pancreas1.34027134
75MP0001944_abnormal_pancreas_morphology1.32391227
76MP0004510_myositis1.31235760
77MP0000703_abnormal_thymus_morphology1.30322376
78MP0000490_abnormal_crypts_of1.29942578
79MP0002970_abnormal_white_adipose1.28310835
80MP0002080_prenatal_lethality1.27506214
81MP0009840_abnormal_foam_cell1.26607895
82MP0001324_abnormal_eye_pigmentation1.23692856
83MP0008469_abnormal_protein_level1.21011132
84MP0003984_embryonic_growth_retardation1.20488538
85MP0002998_abnormal_bone_remodeling1.20089109
86MP0008789_abnormal_olfactory_epithelium1.18049635
87MP0003453_abnormal_keratinocyte_physiol1.18047459
88MP0003806_abnormal_nucleotide_metabolis1.17657657
89MP0003303_peritoneal_inflammation1.17627778
90MP0002088_abnormal_embryonic_growth/wei1.17273970
91MP0000343_altered_response_to1.16675392
92MP0002638_abnormal_pupillary_reflex1.16037671
93MP0008007_abnormal_cellular_replicative1.14241727
94MP0005666_abnormal_adipose_tissue1.14132403
95MP0001672_abnormal_embryogenesis/_devel1.14104908
96MP0005380_embryogenesis_phenotype1.14104908
97MP0000465_gastrointestinal_hemorrhage1.12307432
98MP0003300_gastrointestinal_ulcer1.12219215
99MP0001697_abnormal_embryo_size1.10689234
100MP0001849_ear_inflammation1.10633961
101MP0000750_abnormal_muscle_regeneration1.09507603
102MP0000358_abnormal_cell_content/1.08658554
103MP0000678_abnormal_parathyroid_gland1.08504023
104MP0001851_eye_inflammation1.07891677
105MP0001873_stomach_inflammation1.07650027
106MP0002693_abnormal_pancreas_physiology1.07427356
107MP0002229_neurodegeneration1.06366031
108MP0009780_abnormal_chondrocyte_physiolo1.04041093
109* MP0009333_abnormal_splenocyte_physiolog1.03826545
110MP0002019_abnormal_tumor_incidence1.03663180
111MP0005390_skeleton_phenotype1.02315182
112MP0003448_altered_tumor_morphology1.01871152
113MP0008438_abnormal_cutaneous_collagen0.99724810
114* MP0002398_abnormal_bone_marrow0.99026729
115MP0001348_abnormal_lacrimal_gland0.98805015
116MP0003283_abnormal_digestive_organ0.98730817
117MP0003183_abnormal_peptide_metabolism0.98073268
118MP0000313_abnormal_cell_death0.96885847
119MP0003091_abnormal_cell_migration0.96345767
120MP0002085_abnormal_embryonic_tissue0.96230738
121MP0002722_abnormal_immune_system0.94051199
122MP0001853_heart_inflammation0.93570421
123MP0003279_aneurysm0.93198365
124MP0002084_abnormal_developmental_patter0.92937903
125MP0008058_abnormal_DNA_repair0.91361167
126MP0005310_abnormal_salivary_gland0.91158545
127MP0009764_decreased_sensitivity_to0.90302570
128MP0002086_abnormal_extraembryonic_tissu0.89527867
129MP0002078_abnormal_glucose_homeostasis0.86309836
130MP0000747_muscle_weakness0.86308529
131MP0002269_muscular_atrophy0.84973518
132MP0002796_impaired_skin_barrier0.83714731
133MP0003566_abnormal_cell_adhesion0.83307042
134MP0003123_paternal_imprinting0.83162820
135MP0001958_emphysema0.82718829
136MP0005166_decreased_susceptibility_to0.81964421
137MP0000604_amyloidosis0.81436297
138MP0004883_abnormal_blood_vessel0.80404720
139MP0003866_abnormal_defecation0.80321763
140MP0002090_abnormal_vision0.79226707
141MP0003172_abnormal_lysosome_physiology0.78914581
142MP0002752_abnormal_somatic_nervous0.76732219
143MP0008004_abnormal_stomach_pH0.76150709
144MP0000689_abnormal_spleen_morphology0.75905303
145MP0003329_amyloid_beta_deposits0.75899247
146MP0005621_abnormal_cell_physiology0.75773092
147MP0004197_abnormal_fetal_growth/weight/0.75225283
148MP0005164_abnormal_response_to0.74115627
149MP0003795_abnormal_bone_structure0.73521476
150MP0005384_cellular_phenotype0.71484687
151MP0006036_abnormal_mitochondrial_physio0.70117868
152MP0005083_abnormal_biliary_tract0.69544031
153MP0001764_abnormal_homeostasis0.69071747
154MP0002166_altered_tumor_susceptibility0.69017922
155MP0002277_abnormal_respiratory_mucosa0.68986483
156MP0004084_abnormal_cardiac_muscle0.68713975
157MP0000767_abnormal_smooth_muscle0.68432477
158MP0009931_abnormal_skin_appearance0.67991054
159MP0010234_abnormal_vibrissa_follicle0.67431392
160MP0005501_abnormal_skin_physiology0.67133282
161MP0002127_abnormal_cardiovascular_syste0.67026286
162MP0001663_abnormal_digestive_system0.66991309
163MP0008770_decreased_survivor_rate0.66762120
164MP0009672_abnormal_birth_weight0.66566132
165* MP0002429_abnormal_blood_cell0.65896770
166MP0009115_abnormal_fat_cell0.65628058
167MP0000858_altered_metastatic_potential0.64753389
168MP0002971_abnormal_brown_adipose0.63793101
169MP0003786_premature_aging0.62657888

Predicted human phenotypes

RankGene SetZ-score
1Congenital stationary night blindness (HP:0007642)8.06293974
2* Bony spicule pigmentary retinopathy (HP:0007737)6.79511388
3* Absent rod-and cone-mediated responses on ERG (HP:0007688)6.48002637
4* Abnormal rod and cone electroretinograms (HP:0008323)5.89063472
5Pendular nystagmus (HP:0012043)5.78123471
6Eczematoid dermatitis (HP:0000976)5.46533286
7Central scotoma (HP:0000603)5.45294627
8Recurrent abscess formation (HP:0002722)4.99388611
9Scotoma (HP:0000575)4.84850215
10Recurrent bacterial skin infections (HP:0005406)4.83074429
11Posterior subcapsular cataract (HP:0007787)4.81985890
12Pigmentary retinal degeneration (HP:0001146)4.66848506
13Abnormality of macrophages (HP:0004311)4.59613808
14Abnormality of macular pigmentation (HP:0008002)4.26516486
15Chorioretinal atrophy (HP:0000533)4.07337087
16Myositis (HP:0100614)4.07091151
17Abolished electroretinogram (ERG) (HP:0000550)3.99516544
18* Type II diabetes mellitus (HP:0005978)3.95579536
19Attenuation of retinal blood vessels (HP:0007843)3.78830096
20Obstructive lung disease (HP:0006536)3.66973205
21Chronic obstructive pulmonary disease (HP:0006510)3.66973205
22Severe visual impairment (HP:0001141)3.66425245
23Orchitis (HP:0100796)3.62051068
24Recurrent gram-negative bacterial infections (HP:0005420)3.52285034
25Dyschromatopsia (HP:0007641)3.37248183
26Elevated erythrocyte sedimentation rate (HP:0003565)3.27983180
27Mediastinal lymphadenopathy (HP:0100721)3.23508614
28Cellulitis (HP:0100658)3.21527745
29Gastrointestinal infarctions (HP:0005244)3.12655256
30Gingivitis (HP:0000230)3.07176597
31Recurrent fungal infections (HP:0002841)2.95748463
32* Photophobia (HP:0000613)2.93430387
33Recurrent skin infections (HP:0001581)2.93349094
34Retrobulbar optic neuritis (HP:0100654)2.92993314
35Optic neuritis (HP:0100653)2.92993314
36Hyperacusis (HP:0010780)2.88957634
37Increased IgE level (HP:0003212)2.88409312
38Increased cerebral lipofuscin (HP:0011813)2.85585535
39Abnormality of liposaccharide metabolism (HP:0010968)2.84014650
40Abnormality of glycosphingolipid metabolism (HP:0004343)2.84014650
41Abnormality of glycolipid metabolism (HP:0010969)2.84014650
42Meningitis (HP:0001287)2.78952732
43Urticaria (HP:0001025)2.76582462
44Stomatitis (HP:0010280)2.74708519
45Subcapsular cataract (HP:0000523)2.66402553
46* Constricted visual fields (HP:0001133)2.66068080
47Interstitial pulmonary disease (HP:0006530)2.63573221
48Hypercortisolism (HP:0001578)2.56523848
49Spontaneous hematomas (HP:0007420)2.52787784
50Gastrointestinal inflammation (HP:0004386)2.51964177
51Hand muscle atrophy (HP:0009130)2.51403232
52Petechiae (HP:0000967)2.49608667
53Hepatosplenomegaly (HP:0001433)2.49529808
54Loss of speech (HP:0002371)2.49362939
55Increased neuronal autofluorescent lipopigment (HP:0002074)2.46405081
56Peritonitis (HP:0002586)2.45835703
57Amyloidosis (HP:0011034)2.45282182
58Progressive muscle weakness (HP:0003323)2.45251402
59Increased corneal curvature (HP:0100692)2.44489212
60Keratoconus (HP:0000563)2.44489212
61Prolonged bleeding time (HP:0003010)2.37486917
62Decreased central vision (HP:0007663)2.35659120
63Increased serum ferritin (HP:0003281)2.35624361
64Macular degeneration (HP:0000608)2.35201375
65Dysostosis multiplex (HP:0000943)2.35147079
66Inflammation of the large intestine (HP:0002037)2.33026202
67Chronic mucocutaneous candidiasis (HP:0002728)2.29461356
68Recurrent cutaneous fungal infections (HP:0011370)2.29461356
69Vertebral compression fractures (HP:0002953)2.27120361
70Hypochromic anemia (HP:0001931)2.26886113
71Colitis (HP:0002583)2.24762438
72Cerebral aneurysm (HP:0004944)2.24711655
73Ependymoma (HP:0002888)2.24309706
74Abnormality of the lower motor neuron (HP:0002366)2.22416470
75Recurrent viral infections (HP:0004429)2.21071174
76Encephalitis (HP:0002383)2.19979617
77Purpura (HP:0000979)2.19100041
78Chest pain (HP:0100749)2.18855257
79Hypertensive crisis (HP:0100735)2.18842367
80Abnormal delayed hypersensitivity skin test (HP:0002963)2.16724245
81Vasculitis (HP:0002633)2.14735234
82Episodic fever (HP:0001954)2.14487901
83Keratoconjunctivitis sicca (HP:0001097)2.14012909
84Upper motor neuron abnormality (HP:0002127)2.10828161
85Multiple enchondromatosis (HP:0005701)2.08477804
86Visual hallucinations (HP:0002367)2.07833318
87Increased connective tissue (HP:0009025)2.07140039
88Abnormality of subcutaneous fat tissue (HP:0001001)2.04860199
89Degeneration of anterior horn cells (HP:0002398)2.03269214
90Abnormality of the anterior horn cell (HP:0006802)2.03269214
91Insomnia (HP:0100785)2.03262054
92Hypertriglyceridemia (HP:0002155)2.03134115
93Polygenic inheritance (HP:0010982)2.01936756
94Pustule (HP:0200039)2.00938016
95Angiofibromas (HP:0010615)1.98626445
96Adenoma sebaceum (HP:0009720)1.98626445
97Slow saccadic eye movements (HP:0000514)1.98288854
98Ragged-red muscle fibers (HP:0003200)1.98164832
99Dysautonomia (HP:0002459)1.96016131
100Upper limb amyotrophy (HP:0009129)1.95981670
101Distal upper limb amyotrophy (HP:0007149)1.95981670
102Astrocytoma (HP:0009592)1.94869549
103Abnormality of the astrocytes (HP:0100707)1.94869549
104Bowel diverticulosis (HP:0005222)1.94614747
105Abnormality of the peritoneum (HP:0002585)1.93780072
106* Retinitis pigmentosa (HP:0000510)1.92853984
107Epistaxis (HP:0000421)1.91755317
108Atrophy/Degeneration involving motor neurons (HP:0007373)1.91198924
109Pathologic fracture (HP:0002756)1.91003974
110Segmental peripheral demyelination/remyelination (HP:0003481)1.90967584
111Osteomyelitis (HP:0002754)1.90319505
112Difficulty climbing stairs (HP:0003551)1.89898988
113Thoracolumbar scoliosis (HP:0002944)1.89584486
114Polycythemia (HP:0001901)1.87775731
115Metaphyseal cupping (HP:0003021)1.87262877
116Arterial thrombosis (HP:0004420)1.85293650
117Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.84368410
118Dilatation of the ascending aorta (HP:0005111)1.83006246
119Keratoconjunctivitis (HP:0001096)1.82325043
120Choroideremia (HP:0001139)1.81936775
121Thin bony cortex (HP:0002753)1.81458759
122Abnormality of glycosaminoglycan metabolism (HP:0004371)1.80079944
123Abnormality of mucopolysaccharide metabolism (HP:0011020)1.80079944
124Abnormality of polysaccharide metabolism (HP:0011012)1.80079944
125Glomerulopathy (HP:0100820)1.79975836
126Axonal loss (HP:0003447)1.79705651
127Sepsis (HP:0100806)1.79450020
128Anorexia (HP:0002039)1.79082673
129Abnormal platelet volume (HP:0011876)1.78891286
130Thoracic kyphosis (HP:0002942)1.78388932
131Hemoptysis (HP:0002105)1.78057465
132Cone-rod dystrophy (HP:0000548)1.77592696
133Ankle contracture (HP:0006466)1.77234820
134Achilles tendon contracture (HP:0001771)1.76792427
135Abnormality of iron homeostasis (HP:0011031)1.76553561
136Disproportionate tall stature (HP:0001519)1.76110830
137Skin ulcer (HP:0200042)1.76063144
138Hemorrhage of the eye (HP:0011885)1.76001706
139Decreased electroretinogram (ERG) amplitude (HP:0000654)1.75736870
140Abnormality of the nasal mucosa (HP:0000433)1.74731508
141Retinal atrophy (HP:0001105)1.74076647
142Granulocytopenia (HP:0001913)1.73904811
143Enlarged penis (HP:0000040)1.73640474
144Hypochromic microcytic anemia (HP:0004840)1.73496341
145Annular pancreas (HP:0001734)1.72915828
146Increased IgM level (HP:0003496)1.72340384
147Viral hepatitis (HP:0006562)1.71669983
148Diminished motivation (HP:0000745)1.71283945
149Abnormality of the thoracic spine (HP:0100711)1.70709278
150Mucopolysacchariduria (HP:0008155)1.70484505
151Urinary glycosaminoglycan excretion (HP:0003541)1.70484505
152Gingival bleeding (HP:0000225)1.69771795
153Cerebral hypomyelination (HP:0006808)1.69753444
154Hypermelanotic macule (HP:0001034)1.69283350
155Verrucae (HP:0200043)1.68986081
156Papilloma (HP:0012740)1.68986081
157Progressive visual loss (HP:0000529)1.67791083
158Hypoglycemic coma (HP:0001325)1.66157453
159Entropion (HP:0000621)1.65921518
160Insulin-resistant diabetes mellitus (HP:0000831)1.65490820
161Carpal bone hypoplasia (HP:0001498)1.63805367
162* Wide nasal bridge (HP:0000431)1.62498065
163Abnormality of the motor neurons (HP:0002450)1.61736445
164Abnormal neuron morphology (HP:0012757)1.61736445
165Elfin facies (HP:0004428)1.60178077
166Myoglobinuria (HP:0002913)1.59462143
167Apathy (HP:0000741)1.58355418
168Growth hormone excess (HP:0000845)1.58221543
169Fasciculations (HP:0002380)1.57040706
170Neoplasm of the adrenal cortex (HP:0100641)1.56616930
171Severe short stature (HP:0003510)1.56109105
172Renal duplication (HP:0000075)1.55646292
173Prominent nose (HP:0000448)1.54929633
174Fatigue (HP:0012378)1.54535173
175Microretrognathia (HP:0000308)1.54287569
176Basal cell carcinoma (HP:0002671)1.54283474
177Insulin resistance (HP:0000855)1.51590119
178Macroorchidism (HP:0000053)1.49363938
179Vitreoretinal degeneration (HP:0000655)1.48927803
180Deep palmar crease (HP:0006191)1.48832143
181Glioma (HP:0009733)1.48597740
182Reduced subcutaneous adipose tissue (HP:0003758)1.48517071
183Athetosis (HP:0002305)1.46633242
184Amyotrophic lateral sclerosis (HP:0007354)1.46489923
185Nasal polyposis (HP:0100582)1.45508761
186Bundle branch block (HP:0011710)1.44714595
187Cutaneous melanoma (HP:0012056)1.44466257
188Decreased subcutaneous fat (HP:0001002)1.44445447
189Ventricular fibrillation (HP:0001663)1.44417265
190Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.43519596
191Pelvic girdle muscle weakness (HP:0003749)1.43267128
192Abnormality of pain sensation (HP:0010832)1.42693338
193Impaired pain sensation (HP:0007328)1.42693338
194Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.42360778
195Personality changes (HP:0000751)1.42069302

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB34.12724171
2MAP3K104.04187159
3EEF2K4.01664620
4ERN13.30508569
5PKN23.24476098
6RIPK43.21588895
7NEK12.82148187
8PRPF4B2.79961607
9SCYL22.75377067
10SMG12.70266176
11IRAK42.65825170
12IRAK32.51311993
13NEK22.35633624
14BLK2.08693493
15FLT32.08608241
16MAPKAPK32.08156139
17TYK21.93409474
18GRK11.91548826
19MAP3K31.88356256
20BUB11.80662222
21PASK1.80084570
22CSK1.75618930
23EPHB11.74374942
24CDK121.66605758
25TAOK21.59387745
26TNK21.57098450
27PIM21.53239724
28FES1.47719006
29RPS6KB21.47573038
30HIPK21.47310652
31ZAP701.46716893
32MAP4K11.46154061
33SIK21.45925905
34BCKDK1.39241656
35TAOK11.38749753
36WEE11.35502638
37RIPK11.34070757
38TBK11.33588700
39IRAK21.32590505
40MAP3K131.31809885
41MAP3K11.28451892
42ALK1.27078880
43KDR1.19021081
44RPS6KA41.17148214
45SIK31.14997762
46TESK21.13980195
47HCK1.11193931
48BRSK11.09058896
49ICK1.08956799
50PDPK11.07795378
51LRRK21.05996506
52EIF2AK31.01768207
53FGR1.01454766
54CDK41.00733732
55MAP3K140.99958367
56CCNB10.99827190
57PDGFRA0.98180369
58BRSK20.96993871
59MTOR0.95145457
60TSSK60.93951648
61TTN0.93010077
62CAMKK20.92452320
63MAP3K60.91790023
64MAP3K110.90840827
65CAMKK10.90520830
66PRKD30.83916420
67LATS20.82142253
68NME20.81419569
69KSR20.77423479
70PDK10.76964052
71RPS6KL10.75409220
72RPS6KC10.75409220
73GRK60.75118431
74CDC42BPA0.74954353
75BRAF0.74644912
76MARK30.71199778
77MATK0.71168161
78MAP3K90.70822350
79CSF1R0.70147226
80JAK20.69039439
81PDK30.68991521
82PDK40.68991521
83CDC70.68809373
84ACVR1B0.67748623
85MARK20.67595879
86DYRK30.67044835
87TGFBR10.66502517
88PRKCH0.65893819
89FGFR40.64818693
90RET0.63847771
91LYN0.63831067
92RPS6KA20.63798453
93CDK70.63235653
94STK100.62540714
95SIK10.62419508
96IKBKE0.62317389
97AURKA0.61444233
98CAMK1D0.58965342
99ILK0.57927247
100MAP3K80.56931689
101PLK10.56622063
102BMX0.55683428
103RPS6KA60.55343625
104TTK0.54680140
105LCK0.54560872
106MAP2K30.54127665
107JAK30.53799734
108TESK10.53710178
109MINK10.52964457
110PAK60.52956515
111RAF10.52475145
112IRAK10.51448075
113BTK0.51058139
114PAK20.51009253
115DAPK10.50905075
116NTRK10.49787726
117PRKG20.49438260
118TGFBR20.47961083
119ARAF0.47103821
120JAK10.46605137
121STK380.46377213
122CDK20.45996063
123CHEK10.45585535
124IKBKB0.44395913
125PINK10.44000149
126ITK0.43952500
127DYRK1B0.43727746
128PAK10.42710667
129MAPK120.42680502
130MAPK90.42666127
131ATR0.42326773
132PIM10.42099000
133PRKCI0.42054803
134EPHA20.41791786
135YES10.41761746
136SYK0.40881919
137AKT30.38535720
138MOS0.37943682
139ABL20.36580470
140PAK40.36357157
141CHEK20.36351574
142MAP2K20.36309072
143MAPK110.36162184
144PTK60.35706592
145AKT20.35650242
146PRKAA10.35121283
147RPS6KA10.33941836
148MAPKAPK20.33823283
149PRKD20.30874513

Predicted pathways (KEGG)

RankGene SetZ-score
1Phototransduction_Homo sapiens_hsa047446.78165259
2Osteoclast differentiation_Homo sapiens_hsa043802.68517841
3Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.52514186
4Leishmaniasis_Homo sapiens_hsa051402.40443432
5Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.39945322
6Other glycan degradation_Homo sapiens_hsa005112.38982708
7Olfactory transduction_Homo sapiens_hsa047401.95773402
8Toll-like receptor signaling pathway_Homo sapiens_hsa046201.93901700
9DNA replication_Homo sapiens_hsa030301.93564961
10Tuberculosis_Homo sapiens_hsa051521.82818999
11Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.68187804
12mTOR signaling pathway_Homo sapiens_hsa041501.66770302
13Staphylococcus aureus infection_Homo sapiens_hsa051501.62801637
14Malaria_Homo sapiens_hsa051441.61781631
15Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.60896055
16RNA transport_Homo sapiens_hsa030131.56620387
17Glycosaminoglycan degradation_Homo sapiens_hsa005311.49554932
18Base excision repair_Homo sapiens_hsa034101.49520919
19Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.47400550
20Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.46710357
21Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.44904038
22Spliceosome_Homo sapiens_hsa030401.39682342
23Toxoplasmosis_Homo sapiens_hsa051451.39546739
24Mismatch repair_Homo sapiens_hsa034301.38370592
25Measles_Homo sapiens_hsa051621.34006802
262-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.31792586
27Chemokine signaling pathway_Homo sapiens_hsa040621.29800446
28Influenza A_Homo sapiens_hsa051641.29592612
29Cell cycle_Homo sapiens_hsa041101.28866786
30Phagosome_Homo sapiens_hsa041451.28235371
31Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.27868584
32NOD-like receptor signaling pathway_Homo sapiens_hsa046211.27242124
33Chronic myeloid leukemia_Homo sapiens_hsa052201.26029416
34Thyroid cancer_Homo sapiens_hsa052161.25615633
35Central carbon metabolism in cancer_Homo sapiens_hsa052301.24858008
36Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.24373279
37Salmonella infection_Homo sapiens_hsa051321.23947257
38NF-kappa B signaling pathway_Homo sapiens_hsa040641.23741639
39RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.22926083
40N-Glycan biosynthesis_Homo sapiens_hsa005101.21508180
41Legionellosis_Homo sapiens_hsa051341.19926652
42Primary immunodeficiency_Homo sapiens_hsa053401.18834734
43TNF signaling pathway_Homo sapiens_hsa046681.18230967
44Herpes simplex infection_Homo sapiens_hsa051681.17575741
45Leukocyte transendothelial migration_Homo sapiens_hsa046701.12573491
46Longevity regulating pathway - mammal_Homo sapiens_hsa042111.12467394
47Viral myocarditis_Homo sapiens_hsa054161.11941466
48Acute myeloid leukemia_Homo sapiens_hsa052211.10067867
49Hepatitis C_Homo sapiens_hsa051601.09782079
50Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.09568569
51Allograft rejection_Homo sapiens_hsa053301.09376201
52Graft-versus-host disease_Homo sapiens_hsa053321.07559175
53Synaptic vesicle cycle_Homo sapiens_hsa047211.06130989
54Maturity onset diabetes of the young_Homo sapiens_hsa049501.03274963
55Oocyte meiosis_Homo sapiens_hsa041141.03140250
56mRNA surveillance pathway_Homo sapiens_hsa030151.02930999
57Colorectal cancer_Homo sapiens_hsa052101.02775368
58Insulin signaling pathway_Homo sapiens_hsa049101.01230948
59Neurotrophin signaling pathway_Homo sapiens_hsa047220.99948782
60Thyroid hormone signaling pathway_Homo sapiens_hsa049190.95780485
61Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.95192995
62VEGF signaling pathway_Homo sapiens_hsa043700.93845473
63Insulin secretion_Homo sapiens_hsa049110.93686699
64Autoimmune thyroid disease_Homo sapiens_hsa053200.93337780
65Hematopoietic cell lineage_Homo sapiens_hsa046400.92868715
66Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.92081781
67AMPK signaling pathway_Homo sapiens_hsa041520.89362834
68Pentose phosphate pathway_Homo sapiens_hsa000300.87474893
69RNA polymerase_Homo sapiens_hsa030200.86860247
70Pertussis_Homo sapiens_hsa051330.86840564
71Platelet activation_Homo sapiens_hsa046110.86492503
72Circadian rhythm_Homo sapiens_hsa047100.86110560
73Endometrial cancer_Homo sapiens_hsa052130.85936358
74Sphingolipid signaling pathway_Homo sapiens_hsa040710.84156652
75HIF-1 signaling pathway_Homo sapiens_hsa040660.84124701
76Non-small cell lung cancer_Homo sapiens_hsa052230.84002701
77African trypanosomiasis_Homo sapiens_hsa051430.82996534
78p53 signaling pathway_Homo sapiens_hsa041150.81200800
79Sulfur relay system_Homo sapiens_hsa041220.80692104
80Folate biosynthesis_Homo sapiens_hsa007900.80487670
81Carbohydrate digestion and absorption_Homo sapiens_hsa049730.79947230
82Regulation of autophagy_Homo sapiens_hsa041400.79911407
83Phospholipase D signaling pathway_Homo sapiens_hsa040720.79671690
84Insulin resistance_Homo sapiens_hsa049310.79498203
85Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.79461013
86Jak-STAT signaling pathway_Homo sapiens_hsa046300.79065712
87Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.77861675
88Amoebiasis_Homo sapiens_hsa051460.77331600
89Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.77190660
90Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.77126862
91Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.75213379
92ErbB signaling pathway_Homo sapiens_hsa040120.75161218
93Nucleotide excision repair_Homo sapiens_hsa034200.74809678
94Pyrimidine metabolism_Homo sapiens_hsa002400.74737986
95Epstein-Barr virus infection_Homo sapiens_hsa051690.74340707
96HTLV-I infection_Homo sapiens_hsa051660.74077673
97Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.73432191
98Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.73146869
99Glioma_Homo sapiens_hsa052140.72215093
100Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.71509091
101Type II diabetes mellitus_Homo sapiens_hsa049300.71163448
102Viral carcinogenesis_Homo sapiens_hsa052030.70187871
103Antigen processing and presentation_Homo sapiens_hsa046120.69950795
104Pancreatic secretion_Homo sapiens_hsa049720.69092136
105Galactose metabolism_Homo sapiens_hsa000520.69050492
106GnRH signaling pathway_Homo sapiens_hsa049120.69031352
107Biosynthesis of amino acids_Homo sapiens_hsa012300.67653127
108Glucagon signaling pathway_Homo sapiens_hsa049220.67626175
109Fructose and mannose metabolism_Homo sapiens_hsa000510.65883410
110B cell receptor signaling pathway_Homo sapiens_hsa046620.64227720
111Aldosterone synthesis and secretion_Homo sapiens_hsa049250.64035093
112* Purine metabolism_Homo sapiens_hsa002300.63948624
113Choline metabolism in cancer_Homo sapiens_hsa052310.63669638
114Pancreatic cancer_Homo sapiens_hsa052120.63663514
115Notch signaling pathway_Homo sapiens_hsa043300.63623513
116Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.63482374
117Endocytosis_Homo sapiens_hsa041440.63048553
118Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.63022869
119Dopaminergic synapse_Homo sapiens_hsa047280.62836087
120Prolactin signaling pathway_Homo sapiens_hsa049170.62441970
121Adipocytokine signaling pathway_Homo sapiens_hsa049200.60463526
122Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.60316802
123Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.60225662
124Proteasome_Homo sapiens_hsa030500.58934458
125Cholinergic synapse_Homo sapiens_hsa047250.58417090
126Carbon metabolism_Homo sapiens_hsa012000.58331281
127Estrogen signaling pathway_Homo sapiens_hsa049150.58289089
128Prion diseases_Homo sapiens_hsa050200.57880425
129T cell receptor signaling pathway_Homo sapiens_hsa046600.54934930
130Inositol phosphate metabolism_Homo sapiens_hsa005620.54834869
131Prostate cancer_Homo sapiens_hsa052150.54161972
132Ribosome_Homo sapiens_hsa030100.54076526
133Bladder cancer_Homo sapiens_hsa052190.54045915
134cGMP-PKG signaling pathway_Homo sapiens_hsa040220.52646463
135Proteoglycans in cancer_Homo sapiens_hsa052050.52451721
136Apoptosis_Homo sapiens_hsa042100.52435041
137Lysosome_Homo sapiens_hsa041420.51536116
138Phosphatidylinositol signaling system_Homo sapiens_hsa040700.50683136
139Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.50658455
140Type I diabetes mellitus_Homo sapiens_hsa049400.50001447
141Glycerophospholipid metabolism_Homo sapiens_hsa005640.49418136
142Renal cell carcinoma_Homo sapiens_hsa052110.49228579
143FoxO signaling pathway_Homo sapiens_hsa040680.47868463
144RNA degradation_Homo sapiens_hsa030180.46965668
145Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.45919243
146Small cell lung cancer_Homo sapiens_hsa052220.45903234
147AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.44732593
148Shigellosis_Homo sapiens_hsa051310.43677237
149Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.43281484
150Vibrio cholerae infection_Homo sapiens_hsa051100.43277404
151Hepatitis B_Homo sapiens_hsa051610.42944490

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