IMPDH2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes the rate-limiting enzyme in the de novo guanine nucleotide biosynthesis. It is thus involved in maintaining cellular guanine deoxy- and ribonucleotide pools needed for DNA and RNA synthesis. The encoded protein catalyzes the NAD-dependent oxidation of inosine-5'-monophosphate into xanthine-5'-monophosphate, which is then converted into guanosine-5'-monophosphate. This gene is up-regulated in some neoplasms, suggesting it may play a role in malignant transformation. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1purine nucleobase biosynthetic process (GO:0009113)5.65425960
2nucleobase biosynthetic process (GO:0046112)5.59524631
3maturation of SSU-rRNA (GO:0030490)5.05632369
4establishment of integrated proviral latency (GO:0075713)4.76394254
5formation of translation preinitiation complex (GO:0001731)4.75702730
6DNA strand elongation involved in DNA replication (GO:0006271)4.65063213
7mitotic metaphase plate congression (GO:0007080)4.64395887
8ribosome assembly (GO:0042255)4.63939778
9regulation of translational fidelity (GO:0006450)4.60404454
10DNA replication initiation (GO:0006270)4.59663521
11DNA replication checkpoint (GO:0000076)4.55406724
12ribosome biogenesis (GO:0042254)4.49830465
13DNA strand elongation (GO:0022616)4.42775169
14ribosomal small subunit assembly (GO:0000028)4.41005122
15protein localization to kinetochore (GO:0034501)4.25714139
16ribonucleoprotein complex biogenesis (GO:0022613)4.19030518
17telomere maintenance via semi-conservative replication (GO:0032201)4.17994495
18ribosomal large subunit biogenesis (GO:0042273)4.14445932
19DNA unwinding involved in DNA replication (GO:0006268)4.12062802
20regulation of spindle organization (GO:0090224)4.05822586
21regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.98729527
22IMP biosynthetic process (GO:0006188)3.97281028
23mitotic nuclear envelope disassembly (GO:0007077)3.92829360
24establishment of protein localization to endoplasmic reticulum (GO:0072599)3.87641390
25metaphase plate congression (GO:0051310)3.86721711
26viral transcription (GO:0019083)3.85007748
27translational termination (GO:0006415)3.83340211
28rRNA processing (GO:0006364)3.82619191
29DNA deamination (GO:0045006)3.81615712
30establishment of viral latency (GO:0019043)3.80875506
31protein localization to endoplasmic reticulum (GO:0070972)3.78246154
32regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.75792825
33translational initiation (GO:0006413)3.74873408
34telomere maintenance via recombination (GO:0000722)3.74803921
35ribosomal small subunit biogenesis (GO:0042274)3.71358684
36folic acid metabolic process (GO:0046655)3.71221306
37rRNA metabolic process (GO:0016072)3.70612532
38viral life cycle (GO:0019058)3.69112383
39CENP-A containing nucleosome assembly (GO:0034080)3.66665838
40spliceosomal snRNP assembly (GO:0000387)3.62719736
41membrane disassembly (GO:0030397)3.62669021
42nuclear envelope disassembly (GO:0051081)3.62669021
43protein localization to chromosome, centromeric region (GO:0071459)3.60034207
44DNA replication-dependent nucleosome organization (GO:0034723)3.59877465
45DNA replication-dependent nucleosome assembly (GO:0006335)3.59877465
46mitotic recombination (GO:0006312)3.59599616
47chromatin remodeling at centromere (GO:0031055)3.59441416
48translational elongation (GO:0006414)3.55651548
49nuclear pore organization (GO:0006999)3.54037311
50tRNA aminoacylation for protein translation (GO:0006418)3.51421205
51rRNA modification (GO:0000154)3.50192258
52positive regulation of chromosome segregation (GO:0051984)3.48539275
53IMP metabolic process (GO:0046040)3.48002315
54telomere maintenance via telomere lengthening (GO:0010833)3.46546872
55DNA replication-independent nucleosome assembly (GO:0006336)3.46448063
56DNA replication-independent nucleosome organization (GO:0034724)3.46448063
57termination of RNA polymerase I transcription (GO:0006363)3.44411972
58tRNA aminoacylation (GO:0043039)3.42860838
59amino acid activation (GO:0043038)3.42860838
60protein complex disassembly (GO:0043241)3.42818103
61DNA topological change (GO:0006265)3.42624430
62transcription elongation from RNA polymerase I promoter (GO:0006362)3.41745995
63transcription elongation from RNA polymerase III promoter (GO:0006385)3.41140106
64termination of RNA polymerase III transcription (GO:0006386)3.41140106
65translation (GO:0006412)3.39015091
66mitotic sister chromatid segregation (GO:0000070)3.36438867
67anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.34850166
68folic acid-containing compound biosynthetic process (GO:0009396)3.34569847
69nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.33946291
70L-serine metabolic process (GO:0006563)3.33199957
71proline biosynthetic process (GO:0006561)3.32782688
72proteasome assembly (GO:0043248)3.32397750
73pore complex assembly (GO:0046931)3.31590235
74establishment of chromosome localization (GO:0051303)3.28220391
75macromolecular complex disassembly (GO:0032984)3.27776442
76nucleotide-excision repair, DNA gap filling (GO:0006297)3.25424859
77regulation of mitotic spindle organization (GO:0060236)3.25072393
78regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.25026306
79transcription-coupled nucleotide-excision repair (GO:0006283)3.24858917
80attachment of spindle microtubules to kinetochore (GO:0008608)3.23504685
81transcription from RNA polymerase I promoter (GO:0006360)3.22697926
82pseudouridine synthesis (GO:0001522)3.21510811
83nucleobase-containing small molecule interconversion (GO:0015949)3.19999585
84positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.19371059
85regulation of mitochondrial translation (GO:0070129)3.18959411
86DNA duplex unwinding (GO:0032508)3.18926424
87DNA ligation (GO:0006266)3.16965718
88negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.16913568
89spindle checkpoint (GO:0031577)3.16799814
90histone exchange (GO:0043486)3.16290266
91regulation of chromosome segregation (GO:0051983)3.14487580
92negative regulation of chromosome segregation (GO:0051985)3.14149990
93SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.13981062
94peptidyl-arginine omega-N-methylation (GO:0035247)3.12406063
95maturation of 5.8S rRNA (GO:0000460)3.11079777
96cellular protein complex disassembly (GO:0043624)3.09477380
97DNA geometric change (GO:0032392)3.09314834
98negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.09139121
99negative regulation of sister chromatid segregation (GO:0033046)3.09139121
100negative regulation of mitotic sister chromatid separation (GO:2000816)3.09139121
101negative regulation of mitotic sister chromatid segregation (GO:0033048)3.09139121
102nuclear pore complex assembly (GO:0051292)3.08855217
103cellular component biogenesis (GO:0044085)3.08155034
104cell cycle G1/S phase transition (GO:0044843)3.07713278
105G1/S transition of mitotic cell cycle (GO:0000082)3.07713278
106kinetochore organization (GO:0051383)3.07522936
107mitotic spindle checkpoint (GO:0071174)3.07288482
108transcription initiation from RNA polymerase I promoter (GO:0006361)3.06469493
109double-strand break repair via nonhomologous end joining (GO:0006303)3.05960133
110non-recombinational repair (GO:0000726)3.05960133
111nuclear-transcribed mRNA catabolic process (GO:0000956)3.05914761
112cotranslational protein targeting to membrane (GO:0006613)3.05127910
113protein targeting to ER (GO:0045047)3.04194252
114regulation of nuclear cell cycle DNA replication (GO:0033262)3.04054015
115regulation of translation in response to stress (GO:0043555)3.03864480
116mitotic spindle assembly checkpoint (GO:0007094)3.03484751
1177-methylguanosine mRNA capping (GO:0006370)3.03000716
118spindle assembly checkpoint (GO:0071173)3.02086309
119negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.99109872
120mitotic chromosome condensation (GO:0007076)2.98910359
121negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.98692527
122nuclear envelope organization (GO:0006998)2.97396715
123regulation of mitotic metaphase/anaphase transition (GO:0030071)2.96396733
1247-methylguanosine RNA capping (GO:0009452)2.95870555
125RNA capping (GO:0036260)2.95870555
126sister chromatid segregation (GO:0000819)2.95590159
127base-excision repair (GO:0006284)2.94188470
128mRNA catabolic process (GO:0006402)2.92657133
129Golgi transport vesicle coating (GO:0048200)2.92509135
130COPI coating of Golgi vesicle (GO:0048205)2.92509135
131heterochromatin organization (GO:0070828)2.91800693
132viral mRNA export from host cell nucleus (GO:0046784)2.90000152
133negative regulation of ligase activity (GO:0051352)2.86983982
134negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.86983982
135protein targeting to membrane (GO:0006612)2.85467729
136regulation of translational elongation (GO:0006448)2.85379380
137protein complex localization (GO:0031503)2.81467244
138RNA catabolic process (GO:0006401)2.80484950
139oxidative phosphorylation (GO:0006119)2.79259575
140histone arginine methylation (GO:0034969)2.78454805
141DNA conformation change (GO:0071103)2.78140837
142protein maturation by protein folding (GO:0022417)2.73454476

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.19325173
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.41149886
3FOXM1_23109430_ChIP-Seq_U2OS_Human3.85765435
4EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.65046134
5E2F4_17652178_ChIP-ChIP_JURKAT_Human3.46430915
6MYC_19079543_ChIP-ChIP_MESCs_Mouse3.23065358
7KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.19022535
8ETS1_20019798_ChIP-Seq_JURKAT_Human3.04542636
9EST1_17652178_ChIP-ChIP_JURKAT_Human3.01811251
10* JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.00364289
11FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.93615111
12* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.91758819
13* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.88418148
14GABP_17652178_ChIP-ChIP_JURKAT_Human2.86518036
15CREB1_15753290_ChIP-ChIP_HEK293T_Human2.84607337
16E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.62483629
17* XRN2_22483619_ChIP-Seq_HELA_Human2.38215184
18MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.34996451
19* NELFA_20434984_ChIP-Seq_ESCs_Mouse2.34809615
20HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.31912061
21* VDR_23849224_ChIP-Seq_CD4+_Human2.27813546
22AR_21909140_ChIP-Seq_LNCAP_Human2.21501391
23CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.19542531
24NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.01679371
25CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.00585776
26FOXP3_21729870_ChIP-Seq_TREG_Human2.00164604
27E2F1_18555785_ChIP-Seq_MESCs_Mouse1.99337508
28DCP1A_22483619_ChIP-Seq_HELA_Human1.93817618
29GABP_19822575_ChIP-Seq_HepG2_Human1.92650392
30POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.92344991
31MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.89356299
32NANOG_18555785_ChIP-Seq_MESCs_Mouse1.87861712
33* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.87210246
34E2F1_21310950_ChIP-Seq_MCF-7_Human1.85330780
35HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.81772580
36SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.81732305
37* TTF2_22483619_ChIP-Seq_HELA_Human1.81104089
38THAP11_20581084_ChIP-Seq_MESCs_Mouse1.75006737
39KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.71181808
40EGR1_19374776_ChIP-ChIP_THP-1_Human1.68998421
41ELF1_17652178_ChIP-ChIP_JURKAT_Human1.67450001
42PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.65981336
43YY1_21170310_ChIP-Seq_MESCs_Mouse1.64398096
44CIITA_25753668_ChIP-Seq_RAJI_Human1.60747563
45SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.60585490
46YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.56799792
47FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.53952581
48KDM5A_27292631_Chip-Seq_BREAST_Human1.52313236
49ZFX_18555785_ChIP-Seq_MESCs_Mouse1.49935504
50MYC_22102868_ChIP-Seq_BL_Human1.49602360
51ELK1_19687146_ChIP-ChIP_HELA_Human1.49196455
52ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.45470855
53* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.43527540
54POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.37239031
55STAT3_1855785_ChIP-Seq_MESCs_Mouse1.35176238
56SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.34804118
57HOXB4_20404135_ChIP-ChIP_EML_Mouse1.34581225
58SRF_21415370_ChIP-Seq_HL-1_Mouse1.31755401
59MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.30190028
60* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.27151681
61TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.26064944
62SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.23944113
63CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.21908782
64NOTCH1_21737748_ChIP-Seq_TLL_Human1.20613458
65POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.20117543
66PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.17900253
67TP63_19390658_ChIP-ChIP_HaCaT_Human1.15168063
68ERG_20887958_ChIP-Seq_HPC-7_Mouse1.14962213
69DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.14795246
70PADI4_21655091_ChIP-ChIP_MCF-7_Human1.11059773
71* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.10935126
72E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.10354074
73ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.09462356
74DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.09450515
75ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.09256380
76KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.07396884
77SOX2_18555785_ChIP-Seq_MESCs_Mouse1.06706779
78KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.06648990
79CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.05486506
80PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.05152589
81TFEB_21752829_ChIP-Seq_HELA_Human1.03993067
82ESR1_15608294_ChIP-ChIP_MCF-7_Human1.03584331
83PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.03233063
84CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.01467718
85ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.00490602
86* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.98741065
87SOX17_20123909_ChIP-Seq_XEN_Mouse0.98407684
88CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.97336041
89* CHD1_26751641_Chip-Seq_LNCaP_Human0.97027010
90BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.96939597
91ELK1_22589737_ChIP-Seq_MCF10A_Human0.96103683
92TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.95721302
93CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.92640999
94NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.91903851
95ZNF263_19887448_ChIP-Seq_K562_Human0.90797081
96SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.90452712
97NANOG_21062744_ChIP-ChIP_HESCs_Human0.89515525
98CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.89461778
99MYC_18940864_ChIP-ChIP_HL60_Human0.87268199
100SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.87258755
101CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.84905259
102* FOXP1_21924763_ChIP-Seq_HESCs_Human0.83352599
103TCF3_18692474_ChIP-Seq_MEFs_Mouse0.83090537
104RBPJ_22232070_ChIP-Seq_NCS_Mouse0.82565254
105SPI1_23547873_ChIP-Seq_NB4_Human0.82481262
106SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.81826480
107CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.80409555
108* OCT4_18692474_ChIP-Seq_MEFs_Mouse0.80143684
109NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.78718267
110* SOX2_18692474_ChIP-Seq_MEFs_Mouse0.78104021
111GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.75793614
112* VDR_21846776_ChIP-Seq_THP-1_Human0.75775740
113HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.74427850

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching6.08391356
2MP0003111_abnormal_nucleus_morphology4.95758948
3MP0010094_abnormal_chromosome_stability4.85816522
4MP0004957_abnormal_blastocyst_morpholog4.66959309
5MP0003077_abnormal_cell_cycle4.17717584
6MP0008057_abnormal_DNA_replication3.94155219
7MP0008058_abnormal_DNA_repair3.46281724
8MP0003123_paternal_imprinting2.77704900
9MP0008007_abnormal_cellular_replicative2.75017751
10MP0008932_abnormal_embryonic_tissue2.64804997
11MP0001730_embryonic_growth_arrest2.56468866
12MP0002396_abnormal_hematopoietic_system2.56204825
13MP0003718_maternal_effect2.51724948
14MP0003786_premature_aging2.48075160
15MP0000350_abnormal_cell_proliferation2.31756653
16MP0010307_abnormal_tumor_latency2.08184684
17MP0008877_abnormal_DNA_methylation1.94664316
18MP0001672_abnormal_embryogenesis/_devel1.93420941
19MP0005380_embryogenesis_phenotype1.93420941
20MP0010352_gastrointestinal_tract_polyps1.88220177
21MP0009697_abnormal_copulation1.87989703
22MP0001697_abnormal_embryo_size1.76859967
23MP0003984_embryonic_growth_retardation1.72801487
24* MP0002080_prenatal_lethality1.70406466
25MP0002088_abnormal_embryonic_growth/wei1.68238279
26MP0000490_abnormal_crypts_of1.62786515
27MP0009333_abnormal_splenocyte_physiolog1.59799375
28MP0004808_abnormal_hematopoietic_stem1.58700113
29MP0003567_abnormal_fetal_cardiomyocyte1.58668358
30MP0005501_abnormal_skin_physiology1.57999551
31MP0003705_abnormal_hypodermis_morpholog1.57341084
32MP0010234_abnormal_vibrissa_follicle1.56355097
33MP0002877_abnormal_melanocyte_morpholog1.50765107
34MP0005397_hematopoietic_system_phenotyp1.49629363
35MP0001545_abnormal_hematopoietic_system1.49629363
36MP0002085_abnormal_embryonic_tissue1.48831677
37MP0000313_abnormal_cell_death1.47050858
38MP0008260_abnormal_autophagy1.45105771
39MP0002086_abnormal_extraembryonic_tissu1.41284529
40MP0002796_impaired_skin_barrier1.40040076
41MP0002084_abnormal_developmental_patter1.39100797
42MP0002019_abnormal_tumor_incidence1.37709094
43MP0004233_abnormal_muscle_weight1.31759005
44MP0004185_abnormal_adipocyte_glucose1.31056419
45MP0002210_abnormal_sex_determination1.27177366
46MP0004197_abnormal_fetal_growth/weight/1.23329235
47MP0002697_abnormal_eye_size1.16174167
48MP0002132_abnormal_respiratory_system1.14922505
49MP0001293_anophthalmia1.13687884
50MP0001145_abnormal_male_reproductive1.12783423
51MP0002938_white_spotting1.11431716
52MP0003315_abnormal_perineum_morphology1.10574690
53MP0005377_hearing/vestibular/ear_phenot1.09625783
54MP0003878_abnormal_ear_physiology1.09625783
55MP0003806_abnormal_nucleotide_metabolis1.09054324
56MP0001346_abnormal_lacrimal_gland1.06503650
57MP0003221_abnormal_cardiomyocyte_apopto1.00850956
58MP0000358_abnormal_cell_content/0.97827492
59MP0001929_abnormal_gametogenesis0.97071699
60MP0002722_abnormal_immune_system0.95862143
61MP0002060_abnormal_skin_morphology0.95808471
62MP0003121_genomic_imprinting0.95156028
63MP0000653_abnormal_sex_gland0.94968333
64MP0000703_abnormal_thymus_morphology0.94212538
65MP0009278_abnormal_bone_marrow0.92850616
66MP0002398_abnormal_bone_marrow0.92203655
67MP0009672_abnormal_birth_weight0.91882134
68MP0010030_abnormal_orbit_morphology0.91794134
69MP0000689_abnormal_spleen_morphology0.90087975
70MP0003385_abnormal_body_wall0.89288266
71MP0000762_abnormal_tongue_morphology0.87363176
72MP0008438_abnormal_cutaneous_collagen0.87145868
73MP0005076_abnormal_cell_differentiation0.85862071
74MP0003763_abnormal_thymus_physiology0.83746368
75MP0005384_cellular_phenotype0.82674336
76MP0000750_abnormal_muscle_regeneration0.82542813
77MP0000579_abnormal_nail_morphology0.82283154
78MP0001881_abnormal_mammary_gland0.82212562
79MP0002160_abnormal_reproductive_system0.80983794
80MP0004272_abnormal_basement_membrane0.80077879
81MP0005621_abnormal_cell_physiology0.79748668
82MP0003941_abnormal_skin_development0.79696664
83MP0000566_synostosis0.79481515
84MP0005451_abnormal_body_composition0.78998527
85MP0000537_abnormal_urethra_morphology0.78254967
86MP0003119_abnormal_digestive_system0.77595949
87MP0002009_preneoplasia0.77401054
88MP0003566_abnormal_cell_adhesion0.75862724
89MP0005171_absent_coat_pigmentation0.75483863
90MP0001286_abnormal_eye_development0.75262343
91MP0005408_hypopigmentation0.73991308
92MP0009840_abnormal_foam_cell0.73798322
93* MP0002429_abnormal_blood_cell0.73439439
94MP0002111_abnormal_tail_morphology0.72966980
95MP0001119_abnormal_female_reproductive0.72260941
96MP0009053_abnormal_anal_canal0.69012630
97MP0000678_abnormal_parathyroid_gland0.68999879
98MP0003186_abnormal_redox_activity0.68823995
99MP0005389_reproductive_system_phenotype0.68115214
100MP0001216_abnormal_epidermal_layer0.67899889
101MP0006292_abnormal_olfactory_placode0.67885826
102MP0009703_decreased_birth_body0.66455424
103MP0000627_abnormal_mammary_gland0.66181599
104MP0002092_abnormal_eye_morphology0.66174317
105MP0005257_abnormal_intraocular_pressure0.65660533
106MP0006035_abnormal_mitochondrial_morpho0.65409168
107MP0001849_ear_inflammation0.65162499
108MP0003937_abnormal_limbs/digits/tail_de0.64780840
109MP0005395_other_phenotype0.64709484
110MP0003942_abnormal_urinary_system0.64136979
111MP0003890_abnormal_embryonic-extraembry0.63639940
112MP0002233_abnormal_nose_morphology0.62682792
113MP0000467_abnormal_esophagus_morphology0.62475133
114MP0003943_abnormal_hepatobiliary_system0.62329091
115MP0000428_abnormal_craniofacial_morphol0.62294212
116MP0004264_abnormal_extraembryonic_tissu0.61870711
117MP0002114_abnormal_axial_skeleton0.61808419
118MP0010771_integument_phenotype0.61750901
119MP0000858_altered_metastatic_potential0.61668548
120MP0000465_gastrointestinal_hemorrhage0.61266136
121MP0006036_abnormal_mitochondrial_physio0.61181091
122MP0001542_abnormal_bone_strength0.60742237
123MP0001661_extended_life_span0.60413023
124MP0002653_abnormal_ependyma_morphology0.60246162
125MP0003938_abnormal_ear_development0.59507579
126* MP0000716_abnormal_immune_system0.55524710
127MP0000477_abnormal_intestine_morphology0.55442658
128MP0003699_abnormal_female_reproductive0.54802960
129MP0008995_early_reproductive_senescence0.54656988
130MP0005023_abnormal_wound_healing0.54444589
131MP0005075_abnormal_melanosome_morpholog0.54239769
132MP0001764_abnormal_homeostasis0.51662611
133MP0004147_increased_porphyrin_level0.50814031
134MP0002095_abnormal_skin_pigmentation0.50746494
135MP0006054_spinal_hemorrhage0.50687584
136MP0009379_abnormal_foot_pigmentation0.49703565

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)5.53035959
2Breast hypoplasia (HP:0003187)4.83408322
3Abnormality of cells of the erythroid lineage (HP:0012130)4.38967685
4Abnormal number of erythroid precursors (HP:0012131)4.22091644
5Reticulocytopenia (HP:0001896)4.05555351
6Microvesicular hepatic steatosis (HP:0001414)3.91748539
7Carpal bone hypoplasia (HP:0001498)3.89914196
8Impulsivity (HP:0100710)3.88609732
9Cerebral hypomyelination (HP:0006808)3.87599271
10Rough bone trabeculation (HP:0100670)3.73844643
11Patellar aplasia (HP:0006443)3.55890217
12Oral leukoplakia (HP:0002745)3.46976662
13Aplasia/Hypoplasia of the patella (HP:0006498)3.43074903
14Colon cancer (HP:0003003)3.42228005
15Abnormality of the anterior horn cell (HP:0006802)3.31111276
16Degeneration of anterior horn cells (HP:0002398)3.31111276
17Abnormality of glycolysis (HP:0004366)3.28980132
18Selective tooth agenesis (HP:0001592)3.23501057
19Macrocytic anemia (HP:0001972)3.15513783
20Chromsome breakage (HP:0040012)3.03637185
21Multiple enchondromatosis (HP:0005701)3.03453990
22Abnormality of the preputium (HP:0100587)2.95085558
23Chromosomal breakage induced by crosslinking agents (HP:0003221)2.91325185
24Ependymoma (HP:0002888)2.87332225
25Meckel diverticulum (HP:0002245)2.82971804
26Aplastic anemia (HP:0001915)2.81403643
27Entropion (HP:0000621)2.79135604
28Increased serum pyruvate (HP:0003542)2.78983655
29Absent thumb (HP:0009777)2.78271028
30Microretrognathia (HP:0000308)2.77328563
31Abnormality of chromosome stability (HP:0003220)2.76038935
32Progressive muscle weakness (HP:0003323)2.75428499
33Abnormal gallbladder physiology (HP:0012438)2.75033212
34Cholecystitis (HP:0001082)2.75033212
35Trismus (HP:0000211)2.74558020
36Absent radius (HP:0003974)2.74287732
37Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.70626021
38Abnormality of the umbilical cord (HP:0010881)2.70081239
39Ureteral duplication (HP:0000073)2.69731273
40Abnormal trabecular bone morphology (HP:0100671)2.67703004
41Abnormality of the ileum (HP:0001549)2.64297063
42Pallor (HP:0000980)2.60170882
43Premature ovarian failure (HP:0008209)2.58659841
44Absent forearm bone (HP:0003953)2.53974132
45Aplasia involving forearm bones (HP:0009822)2.53974132
46Medulloblastoma (HP:0002885)2.52309032
47Increased nuchal translucency (HP:0010880)2.51257723
48Neoplasm of the pancreas (HP:0002894)2.49873291
49Abnormality of the labia minora (HP:0012880)2.49220507
50Myelodysplasia (HP:0002863)2.48092314
51Hypoplasia of the capital femoral epiphysis (HP:0003090)2.47841242
52Type I transferrin isoform profile (HP:0003642)2.44638461
53Secondary amenorrhea (HP:0000869)2.44444354
54CNS hypomyelination (HP:0003429)2.43041466
55Aplasia/Hypoplasia of the uvula (HP:0010293)2.42951256
56Bone marrow hypocellularity (HP:0005528)2.42938540
57Hyperglycinemia (HP:0002154)2.38568824
58Progressive external ophthalmoplegia (HP:0000590)2.37645330
59Duodenal stenosis (HP:0100867)2.36388467
60Small intestinal stenosis (HP:0012848)2.36388467
61Abnormality of reticulocytes (HP:0004312)2.34810725
62Glossoptosis (HP:0000162)2.34074326
63Premature graying of hair (HP:0002216)2.33486382
64Agnosia (HP:0010524)2.32660423
65Increased hepatocellular lipid droplets (HP:0006565)2.29699567
66Testicular atrophy (HP:0000029)2.28582989
6711 pairs of ribs (HP:0000878)2.25690707
68Thrombocytosis (HP:0001894)2.21014363
69Megaloblastic anemia (HP:0001889)2.19807863
70Horseshoe kidney (HP:0000085)2.18497418
71Reduced antithrombin III activity (HP:0001976)2.18476869
72Sparse lateral eyebrow (HP:0005338)2.15426533
73Prominent nose (HP:0000448)2.13585258
74Sloping forehead (HP:0000340)2.13386123
75Atresia of the external auditory canal (HP:0000413)2.11888839
76Squamous cell carcinoma (HP:0002860)2.11249638
77Sparse eyelashes (HP:0000653)2.08077270
78Tracheoesophageal fistula (HP:0002575)2.07650494
79Abnormality of methionine metabolism (HP:0010901)2.05687422
80Irregular epiphyses (HP:0010582)2.04634233
81Rhabdomyosarcoma (HP:0002859)2.03572518
82Cellular immunodeficiency (HP:0005374)2.03495015
83Cleft eyelid (HP:0000625)2.02406009
84Pelvic girdle muscle weakness (HP:0003749)2.00483747
85Hypoplasia of the radius (HP:0002984)2.00054226
86Slender long bone (HP:0003100)1.99317052
87Atrophy/Degeneration involving motor neurons (HP:0007373)1.98939462
88Increased serum lactate (HP:0002151)1.98226414
89Abnormal protein N-linked glycosylation (HP:0012347)1.98098256
90Abnormal protein glycosylation (HP:0012346)1.98098256
91Abnormal glycosylation (HP:0012345)1.98098256
92Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.98098256
93Proximal placement of thumb (HP:0009623)1.98076107
94Acute encephalopathy (HP:0006846)1.97744427
95Basal cell carcinoma (HP:0002671)1.96873795
96Lipid accumulation in hepatocytes (HP:0006561)1.96597835
97Spastic diplegia (HP:0001264)1.96270828
98Ragged-red muscle fibers (HP:0003200)1.96227040
99Breech presentation (HP:0001623)1.96003583
100Hyperacusis (HP:0010780)1.95687546
101Abnormal spermatogenesis (HP:0008669)1.95518287
102Abnormal mitochondria in muscle tissue (HP:0008316)1.94361129
103Insomnia (HP:0100785)1.94199686
104Poikiloderma (HP:0001029)1.93079258
105Abnormal number of incisors (HP:0011064)1.92934370
106Hepatocellular necrosis (HP:0001404)1.91748347
107Spinal muscular atrophy (HP:0007269)1.91065322
108Triphalangeal thumb (HP:0001199)1.90000780
109Supernumerary spleens (HP:0009799)1.89570881
110Personality changes (HP:0000751)1.89070041
111Abnormality of the duodenum (HP:0002246)1.88484661
112Microglossia (HP:0000171)1.88405521
113Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.88077906
114Absent epiphyses (HP:0010577)1.88077906
115Short thumb (HP:0009778)1.87483257
116Deviation of the thumb (HP:0009603)1.85990607
117Abnormalities of placenta or umbilical cord (HP:0001194)1.85409686
118Death in infancy (HP:0001522)1.84624176
119Nephroblastoma (Wilms tumor) (HP:0002667)1.83516471
120Lymphoma (HP:0002665)1.82019715
121Acute necrotizing encephalopathy (HP:0006965)1.80802269
122Facial cleft (HP:0002006)1.80652852
123Postnatal microcephaly (HP:0005484)1.79261792
124Overlapping toe (HP:0001845)1.79129854
125Exercise intolerance (HP:0003546)1.78460968
126Pancytopenia (HP:0001876)1.78274086
127Increased CSF lactate (HP:0002490)1.77727729
128Glioma (HP:0009733)1.77298518
129Abnormal lung lobation (HP:0002101)1.76056819
130Pustule (HP:0200039)1.73436391
131Aplasia/Hypoplasia of the sacrum (HP:0008517)1.73144722
132Hyperglycinuria (HP:0003108)1.72827243
133Hepatic necrosis (HP:0002605)1.72825120
134Ectopic kidney (HP:0000086)1.71764887
135Cerebral edema (HP:0002181)1.71471240
136Areflexia of lower limbs (HP:0002522)1.71175552
137Duplication of thumb phalanx (HP:0009942)1.68561644
138High anterior hairline (HP:0009890)1.67843059
139Embryonal renal neoplasm (HP:0011794)1.66758209
140Lactic acidosis (HP:0003128)1.65775835
141Increased intramyocellular lipid droplets (HP:0012240)1.65397472
142Decreased activity of mitochondrial respiratory chain (HP:0008972)1.65078661
143Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.65078661
144Choanal atresia (HP:0000453)1.64938398
145Respiratory difficulties (HP:0002880)1.64361283
146Cortical dysplasia (HP:0002539)1.63936035
147Abnormality of the carotid arteries (HP:0005344)1.60742508
148Single umbilical artery (HP:0001195)1.60022926
149Abnormality of the fetal cardiovascular system (HP:0010948)1.60022926
150Abnormal umbilical cord blood vessels (HP:0011403)1.60022926
151Shoulder girdle muscle weakness (HP:0003547)1.59155051

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB15.59637206
2WEE14.97477363
3VRK23.90853297
4TSSK63.54879983
5CDC73.28836775
6PBK3.18012057
7EIF2AK13.13479412
8SMG13.01193049
9NEK22.92583646
10NME22.71230196
11BRSK22.41325442
12SRPK12.40897506
13STK162.36423475
14NEK12.32504577
15ACVR1B2.25309009
16PLK42.14298666
17TTK2.13280087
18PLK12.04134982
19EIF2AK32.03596112
20MKNK11.99770910
21TAF11.83720577
22PLK31.81231193
23MKNK21.72547890
24DYRK31.68776042
25CCNB11.64503440
26AKT31.62257187
27AURKB1.61987909
28BRSK11.59672680
29CDK71.55801604
30VRK11.52007908
31EEF2K1.51180133
32PASK1.48277287
33ATR1.45034266
34RPS6KB21.43225209
35EPHA21.42880821
36TESK21.34551880
37CHEK21.32720368
38RPS6KA41.32678536
39CDK41.24139558
40TLK11.23013161
41TRIB31.22340466
42AURKA1.21969190
43ZAK1.18937103
44CHEK11.12638951
45MAP3K81.11360678
46ICK1.08607213
47PDK41.01355643
48PDK31.01355643
49ALK1.00670035
50MST1R1.00319959
51TGFBR10.97878754
52PIM20.97756233
53PNCK0.95979206
54MST40.91509386
55STK100.90891167
56PIM10.86330693
57STK40.83158611
58DAPK10.81706814
59* CDK20.77098222
60PAK40.75913719
61CDK190.74763883
62PAK10.73467617
63MAPKAPK50.73264745
64CDK120.72921351
65STK30.71969027
66CSNK2A20.71508320
67EIF2AK20.70668571
68ATM0.69260143
69PRKCI0.67605768
70CSNK2A10.64766070
71MAP4K10.64717972
72PDK20.64382477
73ARAF0.64196822
74SCYL20.61848491
75CDK90.60087077
76ERBB40.58162020
77NUAK10.57581755
78BRAF0.57082850
79CDK10.54726479
80MELK0.52210949
81FLT30.50917663
82CDK80.49684503
83LRRK20.48587653
84BCKDK0.48296998
85MAP2K30.46142974
86RPS6KA50.44963628
87CDK60.43822926
88MET0.43342757
89CSNK1G30.42691027
90LATS20.42442883
91MAP3K100.41943317
92CSNK1E0.41488726
93CDK11A0.39033772
94KDR0.37954754
95NME10.37655103
96DAPK30.36071875
97IRAK30.35773731
98AKT20.34923636
99STK38L0.34024224
100MTOR0.32793760
101BRD40.32066936
102CSNK1A1L0.31695009
103CDK150.31584671
104CDK180.30345968
105TAOK20.29945655
106PAK20.29073837
107PDGFRA0.28878576
108MAPKAPK30.27129160
109PKN20.26457949
110CSNK1G10.26408918
111CLK10.25680407
112PRKDC0.22861533
113ZAP700.22316916
114MAP3K30.20810418
115MARK30.19132644
116ILK0.18619130
117BTK0.18282249
118MAP3K110.17663444
119NEK90.17398757
120STK240.15952762
121RPS6KA10.14276560
122RAF10.13705627
123RPS6KB10.13506567

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.69099103
2Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030084.20042156
3Mismatch repair_Homo sapiens_hsa034303.92639445
4RNA polymerase_Homo sapiens_hsa030203.87507480
5Ribosome_Homo sapiens_hsa030103.54525472
6Proteasome_Homo sapiens_hsa030503.34034835
7RNA transport_Homo sapiens_hsa030133.33253603
8Spliceosome_Homo sapiens_hsa030403.20129641
9Vitamin B6 metabolism_Homo sapiens_hsa007503.07773667
10Base excision repair_Homo sapiens_hsa034102.95413396
11Nucleotide excision repair_Homo sapiens_hsa034202.81435262
12Homologous recombination_Homo sapiens_hsa034402.80056379
13Cell cycle_Homo sapiens_hsa041102.69535611
14Pyrimidine metabolism_Homo sapiens_hsa002402.65084378
15Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.37568400
16One carbon pool by folate_Homo sapiens_hsa006702.33501640
17Fanconi anemia pathway_Homo sapiens_hsa034601.96405642
18Basal transcription factors_Homo sapiens_hsa030221.92873209
19Non-homologous end-joining_Homo sapiens_hsa034501.69820850
20p53 signaling pathway_Homo sapiens_hsa041151.65545387
21RNA degradation_Homo sapiens_hsa030181.65064567
22Folate biosynthesis_Homo sapiens_hsa007901.64334712
23mRNA surveillance pathway_Homo sapiens_hsa030151.57562435
24Pyruvate metabolism_Homo sapiens_hsa006201.48332736
25* Purine metabolism_Homo sapiens_hsa002301.47307368
26Pentose phosphate pathway_Homo sapiens_hsa000301.24769328
27Epstein-Barr virus infection_Homo sapiens_hsa051691.23918555
28Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.23006893
29Cysteine and methionine metabolism_Homo sapiens_hsa002701.14486042
30Parkinsons disease_Homo sapiens_hsa050121.11333657
31Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.10048895
32Fatty acid elongation_Homo sapiens_hsa000621.09753550
33Biosynthesis of amino acids_Homo sapiens_hsa012301.09124603
34Oocyte meiosis_Homo sapiens_hsa041141.00898071
35Oxidative phosphorylation_Homo sapiens_hsa001900.98308400
36Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.98097262
37Antigen processing and presentation_Homo sapiens_hsa046120.98014596
38Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.94075428
39Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.93221167
40Sulfur relay system_Homo sapiens_hsa041220.89847332
41Cyanoamino acid metabolism_Homo sapiens_hsa004600.84367719
42Systemic lupus erythematosus_Homo sapiens_hsa053220.84156929
43Regulation of autophagy_Homo sapiens_hsa041400.82361421
44Selenocompound metabolism_Homo sapiens_hsa004500.80471631
45Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.80227871
46Herpes simplex infection_Homo sapiens_hsa051680.80100922
47Viral carcinogenesis_Homo sapiens_hsa052030.78220416
48Propanoate metabolism_Homo sapiens_hsa006400.74258619
49Steroid biosynthesis_Homo sapiens_hsa001000.72654556
50Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.68259957
51Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.64524025
52* Drug metabolism - other enzymes_Homo sapiens_hsa009830.62126428
53Lysine degradation_Homo sapiens_hsa003100.61980232
54Carbon metabolism_Homo sapiens_hsa012000.60548950
55HTLV-I infection_Homo sapiens_hsa051660.57726381
56Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.57362303
57Alzheimers disease_Homo sapiens_hsa050100.53679716
58Vitamin digestion and absorption_Homo sapiens_hsa049770.53475651
592-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.53179966
60Fructose and mannose metabolism_Homo sapiens_hsa000510.52326768
61Glutathione metabolism_Homo sapiens_hsa004800.50044279
62Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.49772910
63Legionellosis_Homo sapiens_hsa051340.47994384
64Arginine biosynthesis_Homo sapiens_hsa002200.47430915
65Fatty acid metabolism_Homo sapiens_hsa012120.46406522
66Small cell lung cancer_Homo sapiens_hsa052220.42103862
67Thyroid cancer_Homo sapiens_hsa052160.41744681
68Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.40699548
69Protein export_Homo sapiens_hsa030600.37954294
70Glycerophospholipid metabolism_Homo sapiens_hsa005640.35825343
71MicroRNAs in cancer_Homo sapiens_hsa052060.35437072
72Primary immunodeficiency_Homo sapiens_hsa053400.35070896
73Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.34996257
74Apoptosis_Homo sapiens_hsa042100.32473800
75Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.32338375
76Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.30271898
77Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.29891751
78Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.29204505
79* Metabolic pathways_Homo sapiens_hsa011000.28841009
80Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.28680628
81Huntingtons disease_Homo sapiens_hsa050160.28619924
82Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.28274006
83Galactose metabolism_Homo sapiens_hsa000520.26880190
84Adherens junction_Homo sapiens_hsa045200.26847802
85HIF-1 signaling pathway_Homo sapiens_hsa040660.26285233
86N-Glycan biosynthesis_Homo sapiens_hsa005100.26099078
87Transcriptional misregulation in cancer_Homo sapiens_hsa052020.25465683
88Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.25254243
89Measles_Homo sapiens_hsa051620.23190479
90Wnt signaling pathway_Homo sapiens_hsa043100.22316926
91Hippo signaling pathway_Homo sapiens_hsa043900.21692810
92Pancreatic cancer_Homo sapiens_hsa052120.21091309
93NF-kappa B signaling pathway_Homo sapiens_hsa040640.20763450
94Prostate cancer_Homo sapiens_hsa052150.19768251
95Intestinal immune network for IgA production_Homo sapiens_hsa046720.19510628
96Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.19214680
97Sulfur metabolism_Homo sapiens_hsa009200.18425046
98Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.18134888
99mTOR signaling pathway_Homo sapiens_hsa041500.17958265
100Renin-angiotensin system_Homo sapiens_hsa046140.17024548
101Hepatitis B_Homo sapiens_hsa051610.16588137
102NOD-like receptor signaling pathway_Homo sapiens_hsa046210.16320000
103TGF-beta signaling pathway_Homo sapiens_hsa043500.14974531
104Alcoholism_Homo sapiens_hsa050340.14612616
105Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.13549484
106Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.12698573
107Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.12262827
108Arginine and proline metabolism_Homo sapiens_hsa003300.11733140
109Influenza A_Homo sapiens_hsa051640.11521840
110Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.10483128
111Central carbon metabolism in cancer_Homo sapiens_hsa052300.09517827
112Colorectal cancer_Homo sapiens_hsa052100.09063049
113Notch signaling pathway_Homo sapiens_hsa043300.08222436
114Pathways in cancer_Homo sapiens_hsa052000.07870812
115FoxO signaling pathway_Homo sapiens_hsa040680.06916066
116Arachidonic acid metabolism_Homo sapiens_hsa005900.06684397
117Basal cell carcinoma_Homo sapiens_hsa052170.06550542
118Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.06396491
119Shigellosis_Homo sapiens_hsa051310.06282413
120Bladder cancer_Homo sapiens_hsa052190.05824921
121Acute myeloid leukemia_Homo sapiens_hsa052210.05542122
122Chronic myeloid leukemia_Homo sapiens_hsa052200.04982419
123Hedgehog signaling pathway_Homo sapiens_hsa043400.04923684

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