IMPG1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein that is a major component of the retinal interphotoreceptor matrix. The encoded protein is a proteoglycan that is thought to play a role in maintaining viability of photoreceptor cells and in adhesion of the neural retina to the retinal pigment epithelium. Alternate splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of guanylate cyclase activity (GO:0031284)9.95962999
2retinal rod cell development (GO:0046548)8.98807165
3regulation of guanylate cyclase activity (GO:0031282)8.98235663
4GMP metabolic process (GO:0046037)8.97975168
5* visual perception (GO:0007601)8.51854724
6* sensory perception of light stimulus (GO:0050953)8.42276866
7cellular response to light stimulus (GO:0071482)7.35466670
8detection of external stimulus (GO:0009581)7.09439405
9detection of abiotic stimulus (GO:0009582)6.96040382
10eye photoreceptor cell differentiation (GO:0001754)6.67509111
11photoreceptor cell differentiation (GO:0046530)6.67509111
12regulation of cGMP metabolic process (GO:0030823)6.21588649
13retina development in camera-type eye (GO:0060041)6.21542100
14detection of chemical stimulus involved in sensory perception of bitter taste (GO:0001580)6.01130984
15positive regulation of cGMP biosynthetic process (GO:0030828)5.79630865
16regulation of inhibitory postsynaptic membrane potential (GO:0060080)5.70902159
17regulation of cGMP biosynthetic process (GO:0030826)5.43038167
18positive regulation of cGMP metabolic process (GO:0030825)5.12810553
19negative regulation of cardiac muscle hypertrophy (GO:0010614)4.88115735
20cellular response to radiation (GO:0071478)4.77091895
21nonmotile primary cilium assembly (GO:0035058)4.65247046
22response to electrical stimulus (GO:0051602)4.65138847
23positive regulation of synaptic transmission, dopaminergic (GO:0032226)4.60951125
24receptor guanylyl cyclase signaling pathway (GO:0007168)4.58220676
25adaptation of signaling pathway (GO:0023058)4.57073289
26negative regulation of cardiac muscle tissue growth (GO:0055022)4.53392321
27negative regulation of heart growth (GO:0061117)4.53392321
28cell morphogenesis involved in neuron differentiation (GO:0048667)4.47887911
29regulation of G-protein coupled receptor protein signaling pathway (GO:0008277)4.39455615
30negative regulation of muscle hypertrophy (GO:0014741)4.32006465
31estrogen biosynthetic process (GO:0006703)4.13004987
32* sensory perception (GO:0007600)4.04210623
33retinal metabolic process (GO:0042574)4.00339977
34regulation of voltage-gated calcium channel activity (GO:1901385)3.99238385
35response to light stimulus (GO:0009416)3.87293494
36regulation of clathrin-mediated endocytosis (GO:2000369)3.83619520
37retina layer formation (GO:0010842)3.80000613
38neuron development (GO:0048666)3.56060627
39short-term memory (GO:0007614)3.53289370
40detection of chemical stimulus involved in sensory perception of taste (GO:0050912)3.52913074
41protein prenylation (GO:0018342)3.52800038
42prenylation (GO:0097354)3.52800038
43behavioral response to ethanol (GO:0048149)3.51390867
44positive regulation of G-protein coupled receptor protein signaling pathway (GO:0045745)3.42169793
45regulation of penile erection (GO:0060405)3.38449958
46positive regulation of neurotransmitter transport (GO:0051590)3.37907167
47positive regulation of sodium ion transmembrane transporter activity (GO:2000651)3.37331113
48regulation of short-term neuronal synaptic plasticity (GO:0048172)3.34085852
49chemosensory behavior (GO:0007635)3.33443716
50positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.32321847
51response to histamine (GO:0034776)3.30587728
52fat-soluble vitamin metabolic process (GO:0006775)3.30242975
53regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)3.27299492
54regulation of dopamine uptake involved in synaptic transmission (GO:0051584)3.27299492
55multicellular organism reproduction (GO:0032504)3.24230638
56membrane hyperpolarization (GO:0060081)3.23308686
57positive regulation of epidermal growth factor receptor signaling pathway (GO:0045742)3.22481437
58detection of chemical stimulus involved in sensory perception (GO:0050907)3.21346235
59retina homeostasis (GO:0001895)3.17915901
60positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.17786565
61sensory perception of taste (GO:0050909)3.15420932
62negative regulation of cardiac muscle tissue development (GO:0055026)3.15179034
63CDP-diacylglycerol biosynthetic process (GO:0016024)3.13475631
64retinoid metabolic process (GO:0001523)3.11085116
65positive regulation of sodium ion transmembrane transport (GO:1902307)3.06231823
66protein localization to synapse (GO:0035418)3.04053440
67positive regulation of ERBB signaling pathway (GO:1901186)3.01936227
68inner ear receptor cell differentiation (GO:0060113)2.98962025
69diterpenoid metabolic process (GO:0016101)2.87931915
70negative regulation of receptor-mediated endocytosis (GO:0048261)2.85125095
71peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)2.84411630
72phospholipid translocation (GO:0045332)2.84035443
73lipid translocation (GO:0034204)2.84035443
74CDP-diacylglycerol metabolic process (GO:0046341)2.83173980
75synaptic vesicle docking involved in exocytosis (GO:0016081)2.81177956
76negative regulation of catenin import into nucleus (GO:0035414)2.78766099
77sperm motility (GO:0030317)2.77139159
78homocysteine metabolic process (GO:0050667)2.73284478
79regulation of cardiac muscle cell differentiation (GO:2000725)2.68127743
80response to radiation (GO:0009314)2.66492963
81isoprenoid metabolic process (GO:0006720)2.65758833
82post-embryonic morphogenesis (GO:0009886)2.64904086
83terpenoid metabolic process (GO:0006721)2.62371595
84righting reflex (GO:0060013)2.61921947
85synaptic vesicle maturation (GO:0016188)2.59531326
86behavioral response to cocaine (GO:0048148)2.58164540
87ovulation from ovarian follicle (GO:0001542)2.57545055
88axoneme assembly (GO:0035082)2.56115341
89microtubule nucleation (GO:0007020)2.55808604
90cellular response to zinc ion (GO:0071294)2.55774233
91negative regulation of cation channel activity (GO:2001258)2.54183914
92icosanoid secretion (GO:0032309)2.54160621
93arachidonic acid secretion (GO:0050482)2.54160621
94reproduction (GO:0000003)2.53874165
95dopamine receptor signaling pathway (GO:0007212)2.52477578
96startle response (GO:0001964)2.50821270
97synaptic transmission, dopaminergic (GO:0001963)2.50175371
98positive regulation of cyclase activity (GO:0031281)2.49712741
99smooth muscle tissue development (GO:0048745)2.48899106
100negative regulation of calcium ion transmembrane transport (GO:1903170)2.48882078
101negative regulation of calcium ion transmembrane transporter activity (GO:1901020)2.48882078
102glycine transport (GO:0015816)2.47580332
103negative regulation of transcription regulatory region DNA binding (GO:2000678)2.47354216
104regulation of cardiac muscle hypertrophy (GO:0010611)2.46699291
105acrosome reaction (GO:0007340)2.45239833
106cellular response to abiotic stimulus (GO:0071214)2.41936641
107retinol metabolic process (GO:0042572)2.41300947
108negative regulation of peptidyl-threonine phosphorylation (GO:0010801)2.38860529
109protein heterotetramerization (GO:0051290)2.38076973
110white fat cell differentiation (GO:0050872)2.37264099
111regulation of plasminogen activation (GO:0010755)2.35567945
112regulation of muscle hypertrophy (GO:0014743)2.34859430
113positive regulation of endothelial cell differentiation (GO:0045603)2.34294003
114mechanoreceptor differentiation (GO:0042490)2.33052878
115regulation of endothelial cell differentiation (GO:0045601)2.29061036
116regulation of neurotransmitter uptake (GO:0051580)2.28391560
117positive regulation of lyase activity (GO:0051349)2.28385951
118gamma-aminobutyric acid transport (GO:0015812)2.24831274
119positive regulation of insulin-like growth factor receptor signaling pathway (GO:0043568)2.19760904
120positive regulation of gastrulation (GO:2000543)2.18983404
121cilium or flagellum-dependent cell motility (GO:0001539)2.17276582
122cochlea development (GO:0090102)2.14611920
123regulation of muscle adaptation (GO:0043502)2.12965895
124calcium ion-dependent exocytosis (GO:0017156)2.11058763
125single fertilization (GO:0007338)2.09365349
126establishment of protein localization to Golgi (GO:0072600)2.07666116
127regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.06924200
128regulation of lipoprotein metabolic process (GO:0050746)2.06221654
129hair cell differentiation (GO:0035315)2.05561472
130cell migration involved in heart development (GO:0060973)2.04991401
131modified amino acid transport (GO:0072337)2.04137655
132cranial nerve morphogenesis (GO:0021602)2.03950276
133keratan sulfate catabolic process (GO:0042340)2.03122963
134sperm-egg recognition (GO:0035036)2.02901473
135regulation of rhodopsin mediated signaling pathway (GO:0022400)18.1044502
136rhodopsin mediated signaling pathway (GO:0016056)17.6601994
137retinal cone cell development (GO:0046549)16.5024973
138vitamin A metabolic process (GO:0006776)14.3809316
139photoreceptor cell development (GO:0042461)11.9759073
140photoreceptor cell maintenance (GO:0045494)11.6523308
141eye photoreceptor cell development (GO:0042462)11.5130835
142cellular response to electrical stimulus (GO:0071257)11.4682205
143detection of light stimulus involved in sensory perception (GO:0050962)11.2700340
144detection of light stimulus involved in visual perception (GO:0050908)11.2700340
145phototransduction (GO:0007602)10.7182108
146phototransduction, visible light (GO:0007603)10.6499137
147protein-chromophore linkage (GO:0018298)10.5658796
148detection of visible light (GO:0009584)10.1598689
149detection of light stimulus (GO:0009583)10.0992296
150regulation of cyclase activity (GO:0031279)1.99852965
151sperm capacitation (GO:0048240)1.99822320
152regulation of female gonad development (GO:2000194)1.98985055

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.24759123
2EZH2_22144423_ChIP-Seq_EOC_Human4.01683279
3CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse3.57404800
4GBX2_23144817_ChIP-Seq_PC3_Human3.49296088
5VDR_22108803_ChIP-Seq_LS180_Human3.21988308
6GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse3.19163894
7DROSHA_22980978_ChIP-Seq_HELA_Human2.33446382
8GATA1_26923725_Chip-Seq_HPCs_Mouse2.32755251
9CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.10858906
10AR_21572438_ChIP-Seq_LNCaP_Human2.06098795
11* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.03585712
12SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.97520835
13DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.92152011
14IGF1R_20145208_ChIP-Seq_DFB_Human1.89180629
15SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.88368251
16SMAD3_21741376_ChIP-Seq_HESCs_Human1.75569350
17EZH2_27294783_Chip-Seq_ESCs_Mouse1.75489668
18SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.73533394
19* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.73318539
20MTF2_20144788_ChIP-Seq_MESCs_Mouse1.71906999
21SUZ12_27294783_Chip-Seq_ESCs_Mouse1.71761364
22REST_21632747_ChIP-Seq_MESCs_Mouse1.67824534
23FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.64883705
24* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.63635268
25NR3C1_21868756_ChIP-Seq_MCF10A_Human1.63015627
26AR_25329375_ChIP-Seq_VCAP_Human1.60093699
27FOXM1_26456572_ChIP-Seq_MCF-7_Human1.60030958
28SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.58313797
29TCF4_18268006_ChIP-ChIP_LS174T_Human1.57946986
30ZFP57_27257070_Chip-Seq_ESCs_Mouse1.57923810
31IKZF1_21737484_ChIP-ChIP_HCT116_Human1.56652156
32SMAD4_21799915_ChIP-Seq_A2780_Human1.55799460
33CBP_20019798_ChIP-Seq_JUKART_Human1.55459699
34IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.55459699
35CJUN_26792858_Chip-Seq_BT549_Human1.53213528
36MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.52551667
37REST_18959480_ChIP-ChIP_MESCs_Mouse1.52115712
38* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.50944495
39EZH2_18974828_ChIP-Seq_MESCs_Mouse1.50804546
40RNF2_18974828_ChIP-Seq_MESCs_Mouse1.50804546
41* SMAD3_21741376_ChIP-Seq_EPCs_Human1.49649470
42P53_22127205_ChIP-Seq_FIBROBLAST_Human1.49166977
43JARID2_20075857_ChIP-Seq_MESCs_Mouse1.46904071
44* AR_19668381_ChIP-Seq_PC3_Human1.46211999
45ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.44490129
46* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.43791259
47RXR_22108803_ChIP-Seq_LS180_Human1.43265402
48* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.41501074
49EZH2_27304074_Chip-Seq_ESCs_Mouse1.40920434
50RNF2_27304074_Chip-Seq_ESCs_Mouse1.38123870
51SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.37061437
52CDX2_19796622_ChIP-Seq_MESCs_Mouse1.37019837
53STAT3_23295773_ChIP-Seq_U87_Human1.36390160
54* RARB_27405468_Chip-Seq_BRAIN_Mouse1.36256558
55KDM2B_26808549_Chip-Seq_K562_Human1.36164679
56RING1B_27294783_Chip-Seq_NPCs_Mouse1.36109037
57EP300_21415370_ChIP-Seq_HL-1_Mouse1.34738565
58JARID2_20064375_ChIP-Seq_MESCs_Mouse1.34084750
59FUS_26573619_Chip-Seq_HEK293_Human1.31823882
60* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.31332309
61BCAT_22108803_ChIP-Seq_LS180_Human1.31239456
62CDX2_22108803_ChIP-Seq_LS180_Human1.30296060
63TBL1_22424771_ChIP-Seq_293T_Human1.28881535
64TP53_18474530_ChIP-ChIP_U2OS_Human1.28752622
65RUNX2_22187159_ChIP-Seq_PCA_Human1.28594391
66TOP2B_26459242_ChIP-Seq_MCF-7_Human1.28141370
67* KDM2B_26808549_Chip-Seq_REH_Human1.27212343
68TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.25753279
69PRDM14_20953172_ChIP-Seq_ESCs_Human1.25105953
70* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.24545934
71EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.23630136
72SMAD4_21741376_ChIP-Seq_EPCs_Human1.20945650
73* P300_19829295_ChIP-Seq_ESCs_Human1.19864444
74TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.18309157
75BMI1_23680149_ChIP-Seq_NPCS_Mouse1.17858603
76AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.16542078
77CTNNB1_20460455_ChIP-Seq_HCT116_Human1.15180502
78ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.15009324
79* CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.13502720
80GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.12125489
81GATA2_21666600_ChIP-Seq_HMVEC_Human1.11596650
82ESR2_21235772_ChIP-Seq_MCF-7_Human1.11593414
83TAL1_26923725_Chip-Seq_HPCs_Mouse1.10917938
84TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.10483511
85BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.10015670
86* CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.08863173
87WDR5_24793694_ChIP-Seq_LNCAP_Human1.08785137
88NANOG_18555785_Chip-Seq_ESCs_Mouse1.08654409
89TCF4_23295773_ChIP-Seq_U87_Human1.08105171
90GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.07227652
91ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.06131942
92SMAD4_21741376_ChIP-Seq_HESCs_Human1.05839334
93THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.05582303
94TAF15_26573619_Chip-Seq_HEK293_Human1.05549098
95CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.04968443
96RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.04854575
97TCF4_22108803_ChIP-Seq_LS180_Human1.04716275
98NFYB_21822215_ChIP-Seq_K562_Human1.04189261
99YAP1_20516196_ChIP-Seq_MESCs_Mouse1.04162014
100SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.01997681
101TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.01663176
102PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.00956448
103ER_23166858_ChIP-Seq_MCF-7_Human1.00757903
104NR3C1_23031785_ChIP-Seq_PC12_Mouse1.00609237
105FOXA1_21572438_ChIP-Seq_LNCaP_Human0.99609665
106NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.98636215
107EED_16625203_ChIP-ChIP_MESCs_Mouse0.98273482
108SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.98256413
109* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.97843952
110MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.97273101
111LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.97199797
112CTCF_27219007_Chip-Seq_Bcells_Human0.96863779
113AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.96840738
114LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.96279191
115ZNF217_24962896_ChIP-Seq_MCF-7_Human0.96261418
116CBX2_27304074_Chip-Seq_ESCs_Mouse0.96200382
117TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.95989132
118CTBP1_25329375_ChIP-Seq_LNCAP_Human0.95864753
119PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.94095227
120VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.94041648
121CTBP2_25329375_ChIP-Seq_LNCAP_Human0.93966070
122TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.93777628
123POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.93777628
124AHR_22903824_ChIP-Seq_MCF-7_Human0.93476009
125* ISL1_27105846_Chip-Seq_CPCs_Mouse0.93227857
126GF1_26923725_Chip-Seq_HPCs_Mouse0.91603228
127SMC4_20622854_ChIP-Seq_HELA_Human0.91080119
128RING1B_27294783_Chip-Seq_ESCs_Mouse0.88677137
129EGR1_19032775_ChIP-ChIP_M12_Human0.88366511
130CBP_21632823_ChIP-Seq_H3396_Human0.87973073
131TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.87913514
132RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.87324685
133ARNT_22903824_ChIP-Seq_MCF-7_Human0.87306304
134PIAS1_25552417_ChIP-Seq_VCAP_Human0.86673208
135DPY_21335234_ChIP-Seq_ESCs_Mouse0.86448290
136TAF2_19829295_ChIP-Seq_ESCs_Human0.86380026
137SMAD3_21741376_ChIP-Seq_ESCs_Human0.86046014
138ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.85325129
139DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.85062022
140E2F1_18555785_Chip-Seq_ESCs_Mouse0.84898471
141WT1_25993318_ChIP-Seq_PODOCYTE_Human0.84730634

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005551_abnormal_eye_electrophysiolog9.84917208
2MP0005253_abnormal_eye_physiology6.86568213
3MP0006072_abnormal_retinal_apoptosis6.37169128
4MP0005195_abnormal_posterior_eye3.85214428
5MP0003950_abnormal_plasma_membrane3.70805494
6MP0001324_abnormal_eye_pigmentation3.42923124
7MP0005391_vision/eye_phenotype3.31628687
8MP0002090_abnormal_vision3.06610033
9MP0005423_abnormal_somatic_nervous2.86943432
10MP0002229_neurodegeneration2.68543803
11MP0002638_abnormal_pupillary_reflex2.60399052
12MP0001986_abnormal_taste_sensitivity2.28621911
13MP0003011_delayed_dark_adaptation11.0193066
14MP0002752_abnormal_somatic_nervous1.95828374
15MP0001764_abnormal_homeostasis1.91205924
16MP0001346_abnormal_lacrimal_gland1.78034437
17MP0002653_abnormal_ependyma_morphology1.50792172
18MP0004019_abnormal_vitamin_homeostasis1.49362769
19MP0005410_abnormal_fertilization1.44046651
20MP0002882_abnormal_neuron_morphology1.41781022
21MP0003183_abnormal_peptide_metabolism1.18747246
22MP0004233_abnormal_muscle_weight1.16355472
23MP0001502_abnormal_circadian_rhythm1.12484659
24MP0001984_abnormal_olfaction1.03170385
25MP0002822_catalepsy1.02223608
26MP0001486_abnormal_startle_reflex1.01880668
27MP0004270_analgesia1.01163325
28MP0004885_abnormal_endolymph1.00433336
29MP0005377_hearing/vestibular/ear_phenot0.92300091
30MP0003878_abnormal_ear_physiology0.92300091
31MP0006292_abnormal_olfactory_placode0.92211964
32MP0005197_abnormal_uvea_morphology0.90343355
33MP0010368_abnormal_lymphatic_system0.88928229
34MP0005670_abnormal_white_adipose0.86071843
35MP0003880_abnormal_central_pattern0.84454618
36MP0001485_abnormal_pinna_reflex0.83249644
37MP0002332_abnormal_exercise_endurance0.83247021
38MP0005360_urolithiasis0.82922345
39MP0002272_abnormal_nervous_system0.82283434
40MP0005394_taste/olfaction_phenotype0.80098390
41MP0005499_abnormal_olfactory_system0.80098390
42MP0008995_early_reproductive_senescence0.78142195
43MP0003879_abnormal_hair_cell0.76221405
44MP0003136_yellow_coat_color0.75875478
45MP0002127_abnormal_cardiovascular_syste0.74760248
46MP0003634_abnormal_glial_cell0.70773676
47MP0000566_synostosis0.70323530
48MP0004859_abnormal_synaptic_plasticity0.67297196
49MP0000465_gastrointestinal_hemorrhage0.65492281
50MP0002064_seizures0.65046497
51MP0010030_abnormal_orbit_morphology0.64222163
52MP0002734_abnormal_mechanical_nocicepti0.63857292
53MP0008789_abnormal_olfactory_epithelium0.63736389
54MP0009046_muscle_twitch0.62791498
55MP0003635_abnormal_synaptic_transmissio0.62150572
56MP0003718_maternal_effect0.60183016
57MP0002009_preneoplasia0.59011212
58MP0001963_abnormal_hearing_physiology0.58419533
59MP0000516_abnormal_urinary_system0.56094382
60MP0005367_renal/urinary_system_phenotyp0.56094382
61MP0001968_abnormal_touch/_nociception0.53804628
62MP0001286_abnormal_eye_development0.53475829
63MP0000534_abnormal_ureter_morphology0.53406475
64MP0002572_abnormal_emotion/affect_behav0.53212047
65MP0005187_abnormal_penis_morphology0.52028301
66MP0008004_abnormal_stomach_pH0.51827051
67MP0006276_abnormal_autonomic_nervous0.51799770
68MP0002063_abnormal_learning/memory/cond0.51257951
69MP0002067_abnormal_sensory_capabilities0.49899783
70MP0003698_abnormal_male_reproductive0.49809898
71MP0005503_abnormal_tendon_morphology0.49728901
72MP0004742_abnormal_vestibular_system0.49565515
73MP0005386_behavior/neurological_phenoty0.49150675
74MP0004924_abnormal_behavior0.49150675
75MP0009745_abnormal_behavioral_response0.48962417
76MP0002735_abnormal_chemical_nociception0.48114685
77MP0001756_abnormal_urination0.46136938
78MP0005167_abnormal_blood-brain_barrier0.46102476
79MP0002282_abnormal_trachea_morphology0.44146316
80MP0005275_abnormal_skin_tensile0.42278456
81MP0003045_fibrosis0.41352272
82MP0002102_abnormal_ear_morphology0.39593329
83MP0005647_abnormal_sex_gland0.38750224
84MP0005376_homeostasis/metabolism_phenot0.38720495
85MP0002295_abnormal_pulmonary_circulatio0.38490870
86MP0001929_abnormal_gametogenesis0.36749905
87MP0005395_other_phenotype0.35960612
88MP0004215_abnormal_myocardial_fiber0.34860117
89MP0009780_abnormal_chondrocyte_physiolo0.33761921
90MP0005171_absent_coat_pigmentation0.33728855
91MP0000026_abnormal_inner_ear0.32098685
92MP0004142_abnormal_muscle_tone0.32093429
93MP0004085_abnormal_heartbeat0.31892863
94MP0005620_abnormal_muscle_contractility0.30369138
95MP0000427_abnormal_hair_cycle0.30143545
96MP0000647_abnormal_sebaceous_gland0.30129091
97MP0002160_abnormal_reproductive_system0.29318613
98MP0010386_abnormal_urinary_bladder0.29205696
99MP0002161_abnormal_fertility/fecundity0.28996058
100MP0008569_lethality_at_weaning0.28349040
101MP0002938_white_spotting0.27811360
102MP0004782_abnormal_surfactant_physiolog0.27423785
103MP0000631_abnormal_neuroendocrine_gland0.27349561
104MP0004145_abnormal_muscle_electrophysio0.26628611
105MP0001905_abnormal_dopamine_level0.26242114
106MP0005332_abnormal_amino_acid0.26055278
107MP0002066_abnormal_motor_capabilities/c0.25165784
108MP0005248_abnormal_Harderian_gland0.24940187
109MP0000767_abnormal_smooth_muscle0.24810335
110MP0003646_muscle_fatigue0.24530203
111MP0001299_abnormal_eye_distance/0.24418525
112MP0002168_other_aberrant_phenotype0.24278238
113MP0002184_abnormal_innervation0.23820088
114MP0000013_abnormal_adipose_tissue0.23799976
115MP0000653_abnormal_sex_gland0.23594015
116MP0002152_abnormal_brain_morphology0.22773859
117MP0002557_abnormal_social/conspecific_i0.21881633
118MP0005646_abnormal_pituitary_gland0.21826316
119MP0000778_abnormal_nervous_system0.21522876
120MP0002234_abnormal_pharynx_morphology0.20987420
121MP0003890_abnormal_embryonic-extraembry0.20505717
122MP0002108_abnormal_muscle_morphology0.20235299
123MP0001661_extended_life_span0.19127503
124MP0004811_abnormal_neuron_physiology0.18899891
125MP0005595_abnormal_vascular_smooth0.18348510
126MP0001501_abnormal_sleep_pattern0.18281688
127MP0002697_abnormal_eye_size0.17708098
128MP0005076_abnormal_cell_differentiation0.16503302
129MP0001915_intracranial_hemorrhage0.15901943
130MP0001970_abnormal_pain_threshold0.15479416
131MP0005193_abnormal_anterior_eye0.15299051
132MP0002928_abnormal_bile_duct0.14665987
133MP0004043_abnormal_pH_regulation0.14022704
134MP0003943_abnormal_hepatobiliary_system0.13580103
135MP0003638_abnormal_response/metabolism_0.13439340
136MP0003632_abnormal_nervous_system0.13281781
137MP0003633_abnormal_nervous_system0.13202229
138MP0003252_abnormal_bile_duct0.13116075
139MP0001177_atelectasis0.12712124
140MP0005330_cardiomyopathy0.12029333
141MP0002972_abnormal_cardiac_muscle0.10905265
142MP0001188_hyperpigmentation0.10817633
143MP0003631_nervous_system_phenotype0.10450966
144MP0001879_abnormal_lymphatic_vessel0.09812049
145MP0005310_abnormal_salivary_gland0.09485673

Predicted human phenotypes

RankGene SetZ-score
1Abnormal rod and cone electroretinograms (HP:0008323)9.78655680
2Pigmentary retinal degeneration (HP:0001146)9.02362863
3Central scotoma (HP:0000603)8.65467767
4Abnormality of macular pigmentation (HP:0008002)8.37092509
5Chorioretinal atrophy (HP:0000533)7.95262023
6Scotoma (HP:0000575)7.70143398
7Pendular nystagmus (HP:0012043)7.67979349
8Attenuation of retinal blood vessels (HP:0007843)7.66499122
9Abolished electroretinogram (ERG) (HP:0000550)6.73556473
10Decreased central vision (HP:0007663)6.62986074
11Photophobia (HP:0000613)5.85765454
12Type II diabetes mellitus (HP:0005978)5.57575830
13Vitreoretinal degeneration (HP:0000655)5.31268489
14Macular degeneration (HP:0000608)5.30451287
15Posterior subcapsular cataract (HP:0007787)5.07105384
16Severe visual impairment (HP:0001141)5.00234103
17Cone-rod dystrophy (HP:0000548)4.73583959
18Keratoconus (HP:0000563)4.65066293
19Increased corneal curvature (HP:0100692)4.65066293
20Constricted visual fields (HP:0001133)4.48009048
21Retinitis pigmentosa (HP:0000510)4.31612168
22Decreased electroretinogram (ERG) amplitude (HP:0000654)3.70341458
23Progressive visual loss (HP:0000529)3.24732711
24Subcapsular cataract (HP:0000523)3.10321511
25Action tremor (HP:0002345)3.07211993
26Congenital sensorineural hearing impairment (HP:0008527)3.02884180
27Retinal atrophy (HP:0001105)2.98241575
28Optic disc pallor (HP:0000543)2.62741096
29Abnormality of alanine metabolism (HP:0010916)2.59826101
30Hyperalaninemia (HP:0003348)2.59826101
31Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.59826101
32Wide nasal bridge (HP:0000431)2.48562674
33* Choroideremia (HP:0001139)2.44545621
34Gait imbalance (HP:0002141)2.22475737
35Congenital primary aphakia (HP:0007707)2.21489019
36Ulnar claw (HP:0001178)2.13441680
37Congenital stationary night blindness (HP:0007642)14.5464016
38Bony spicule pigmentary retinopathy (HP:0007737)11.6326640
39Absent rod-and cone-mediated responses on ERG (HP:0007688)10.5685973
40Dyschromatopsia (HP:0007641)10.1216906
41White forelock (HP:0002211)1.99442917
42Nephrogenic diabetes insipidus (HP:0009806)1.97203888
43Insidious onset (HP:0003587)1.94593855
44Termporal pattern (HP:0011008)1.94593855
45Hypopigmentation of the fundus (HP:0007894)1.92339987
46Medial flaring of the eyebrow (HP:0010747)1.88237960
47Tubulointerstitial nephritis (HP:0001970)1.88129025
48Birth length less than 3rd percentile (HP:0003561)1.83311249
49Upper limb muscle weakness (HP:0003484)1.76136325
50Horizontal nystagmus (HP:0000666)1.75333749
51Patchy hypopigmentation of hair (HP:0011365)1.72948293
52Potter facies (HP:0002009)1.71122314
53Facial shape deformation (HP:0011334)1.71122314
54Polar cataract (HP:0010696)1.70652000
55Poor coordination (HP:0002370)1.69055424
56Esophageal varix (HP:0002040)1.68530027
57Hypoplasia of the iris (HP:0007676)1.65660958
58Lip pit (HP:0100267)1.63444760
59True hermaphroditism (HP:0010459)1.61780024
60Spontaneous abortion (HP:0005268)1.60578354
61Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)1.58443525
62Optic atrophy (HP:0000648)1.58148218
63Insulin-resistant diabetes mellitus (HP:0000831)1.57935142
64Hypoplastic ischia (HP:0003175)1.53672353
65Vaginal atresia (HP:0000148)1.53223264
66Abnormality of the ischium (HP:0003174)1.52494108
67Interstitial pulmonary disease (HP:0006530)1.50877827
68Genital tract atresia (HP:0001827)1.45772528
69Progressive sensorineural hearing impairment (HP:0000408)1.45392964
70Abnormal cartilage morphology (HP:0002763)1.45138523
71Severe Myopia (HP:0011003)1.43356700
72Portal hypertension (HP:0001409)1.40905193
73Pancreatic fibrosis (HP:0100732)1.39761752
74Chronic sinusitis (HP:0011109)1.33703446
75Complement deficiency (HP:0004431)1.32379236
76Dysdiadochokinesis (HP:0002075)1.32174100
77Epileptic encephalopathy (HP:0200134)1.32096050
78Postural tremor (HP:0002174)1.29843597
79Aplasia/Hypoplasia of the lens (HP:0008063)1.29200727
80Hypoplasia of the uterus (HP:0000013)1.27668208
81Abnormality of the epiphyses of the hand (HP:0005924)1.26487577
82Febrile seizures (HP:0002373)1.25428113
83Abnormality of the parathyroid morphology (HP:0011766)1.23664557
84Abnormality of the hepatic vasculature (HP:0006707)1.23172934
85Segmental peripheral demyelination/remyelination (HP:0003481)1.23168003
86Abnormality involving the epiphyses of the upper limbs (HP:0003839)1.23151375
87Conjunctival telangiectasia (HP:0000524)1.19614355
88Decreased number of peripheral myelinated nerve fibers (HP:0003380)1.18972111
89Pulmonary artery stenosis (HP:0004415)1.16972293
90Abnormality of proline metabolism (HP:0010907)1.16830745
91Hydroxyprolinuria (HP:0003080)1.16830745
92Abdominal situs inversus (HP:0003363)1.16156902
93Abnormality of abdominal situs (HP:0011620)1.16156902
94Rhinitis (HP:0012384)1.15179024
95Hypoalphalipoproteinemia (HP:0003233)1.14716218
96Cystic liver disease (HP:0006706)1.14524093
97Spontaneous hematomas (HP:0007420)1.13409474
98Pancreatic cysts (HP:0001737)1.12939397
99Abnormality of the nasal septum (HP:0000419)1.11724707
100Abnormal pupillary function (HP:0007686)1.11649869
101Pheochromocytoma (HP:0002666)1.09814370
102Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.09683166
103Astigmatism (HP:0000483)1.08467092
104Complete atrioventricular canal defect (HP:0001674)1.07964628
105Abnormality of the fovea (HP:0000493)1.07592760
106Steppage gait (HP:0003376)1.07345918
107Cubitus valgus (HP:0002967)1.07269253
108Bicornuate uterus (HP:0000813)1.07149413
109Hypoplasia of the fovea (HP:0007750)1.05275388
110Aplasia/Hypoplasia of the fovea (HP:0008060)1.05275388
111Oligodactyly (hands) (HP:0001180)1.04168769
112Progressive cerebellar ataxia (HP:0002073)1.04003434
113Deep philtrum (HP:0002002)1.03802387
114Recurrent sinusitis (HP:0011108)1.02891802
115Hyperkalemia (HP:0002153)1.02718831
116Calf muscle hypertrophy (HP:0008981)1.02010277
117Bronchomalacia (HP:0002780)1.01737214
118Truncal ataxia (HP:0002078)1.00155786
119Chorioretinal coloboma (HP:0000567)0.98633524
120Aplasia/Hypoplasia of the tongue (HP:0010295)0.94460418
121Sclerocornea (HP:0000647)0.91986543
122Specific learning disability (HP:0001328)0.90234247
123Broad foot (HP:0001769)0.90194136
124Left ventricular hypertrophy (HP:0001712)0.89186737
125Genetic anticipation (HP:0003743)0.88749936
126Hypermetropia (HP:0000540)0.85099073
127Broad-based gait (HP:0002136)0.83670733
128Asthma (HP:0002099)0.82952625
129Abnormality of dental color (HP:0011073)0.82868911
130Abnormality of midbrain morphology (HP:0002418)0.82289703
131Molar tooth sign on MRI (HP:0002419)0.82289703
132Furrowed tongue (HP:0000221)0.81464310
133Chronic hepatic failure (HP:0100626)0.80586672
134Visual hallucinations (HP:0002367)0.79643040
135Decreased testicular size (HP:0008734)0.79515732
136Prolonged QT interval (HP:0001657)0.78468461
137Aplasia/Hypoplasia of the macula (HP:0008059)0.78333908
138* Retinal detachment (HP:0000541)0.75808830
139Hyperventilation (HP:0002883)0.74482105
140Aqueductal stenosis (HP:0002410)0.74258003
141Abnormality of the fingertips (HP:0001211)0.74149096
142Anencephaly (HP:0002323)0.73964183
143Corneal dystrophy (HP:0001131)0.69796142
144Macroorchidism (HP:0000053)0.69747299
145Aplasia/Hypoplasia affecting the retina (HP:0008061)0.69574641
146Lymphopenia (HP:0001888)0.69532721
147Congenital hepatic fibrosis (HP:0002612)0.68985292
148Gaze-evoked nystagmus (HP:0000640)0.66902284
149Postaxial hand polydactyly (HP:0001162)0.66511308
150Abnormal EKG (HP:0003115)0.65870378
151Cerebellar dysplasia (HP:0007033)0.64847844
152Short foot (HP:0001773)0.62705791
153Nephronophthisis (HP:0000090)0.62329599
154Abnormality of cells of the lymphoid lineage (HP:0012140)0.62286217
155Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)0.62103707
156Dental crowding (HP:0000678)0.60831356
157Hypodontia (HP:0000668)0.60617420
158Postaxial foot polydactyly (HP:0001830)0.59032256

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PBK5.67304386
2PINK12.90930238
3STK242.51666233
4IRAK22.11492554
5MST42.06696009
6GRK111.5590905
7PIK3CG1.96521527
8BRD41.89936841
9SIK21.85425477
10CAMK1G1.82033175
11INSRR1.79205806
12ADRBK11.72126471
13MAPK71.62883807
14STK391.56961775
15CDK121.50624409
16CAMK1D1.48286520
17TAOK31.44695905
18MAPK121.37598381
19BMPR1B1.35927440
20OBSCN1.33657124
21TTN1.29106622
22HIPK21.26242260
23MAP3K101.24918125
24MAP3K41.23185577
25SGK4941.21702148
26SGK2231.21702148
27EPHA31.21315384
28STK381.21004833
29PNCK1.20318840
30TIE11.18075586
31SGK21.14287816
32AKT31.12030266
33MET1.11672276
34PLK41.09770945
35PTK2B1.09458685
36CCNB11.05582692
37PAK61.05483185
38CSNK1D1.04343313
39MARK11.04308079
40EPHB21.01381208
41TGFBR21.00656748
42STK38L0.97377239
43PRKCH0.96878449
44BRSK20.96811164
45ICK0.96074437
46TRIM280.94931232
47SGK30.94007845
48EPHB10.94004238
49MAP3K30.92516543
50PRKCZ0.92423489
51CDK30.89065038
52TRPM70.87168037
53ERBB20.86512461
54FER0.81987873
55WNK10.80327528
56RPS6KA40.78931370
57MST1R0.77554331
58MYLK0.74329471
59ACVR1B0.73703124
60TESK10.73133549
61WNK40.72808656
62PRKCB0.72422648
63CASK0.72077728
64PRKD30.71916573
65MAP2K70.68903891
66CAMKK10.68376888
67TTK0.68180220
68PRKG20.67533723
69CAMKK20.67147319
70LATS10.67049468
71PLK20.67011069
72CAMK2D0.66801643
73PRKAA20.66506077
74GRK50.65250772
75DYRK1A0.65082964
76FES0.63728619
77OXSR10.63021804
78MAPKAPK30.62299557
79NTRK30.61343314
80PRKAA10.60574730
81MAP3K90.60132311
82MAPK150.58525212
83PRKACG0.57242627
84SGK10.56786092
85BRAF0.56719969
86CAMK10.56675860
87PKN20.55984449
88RPS6KA30.55668110
89CDK90.55380178
90NEK60.54720146
91PRKD20.53440236
92DDR20.51775648
93FRK0.51707478
94LMTK20.51524166
95STK110.50029037
96PHKG10.48581034
97PHKG20.48581034
98CDK50.47892367
99PKN10.46141390
100PRPF4B0.45962583
101MUSK0.45621593
102CAMK40.44899279
103AKT20.44530349
104NEK20.43978598
105MTOR0.43845079
106CAMK2A0.43683351
107PRKCE0.43654380
108PTK20.43618636
109GSK3B0.43572863
110ILK0.41553762
111PRKDC0.40073435
112MAPK140.39331710
113RPS6KB20.39040933
114TGFBR10.38748952
115DYRK1B0.38703989
116MAP3K70.38647667
117PRKCG0.36774951
118MAPK100.36628436
119PRKD10.36005115
120BRSK10.35940597
121ARAF0.35813561
122MAPK90.35722259
123STK30.35292877
124PLK30.35147905
125PRKACA0.34470832
126YES10.34354006
127WEE10.34334624
128SIK30.33113537
129SIK10.32350026
130CDC42BPA0.32324259
131MAP2K40.32223675
132MKNK20.31893178
133NTRK20.31365243
134MAP3K130.30507028
135FGFR20.30103593
136CDK10.29440124
137RPS6KB10.28820969
138MINK10.28708888
139PRKCA0.27584032
140EPHA40.27279010
141NUAK10.25787045
142PAK30.24673787
143PIK3CA0.24264689
144PRKCI0.23635575
145CHEK20.23127170
146JAK10.23085492
147MAPK30.21752221
148MAP2K10.19731213
149MAPK80.19683116
150SRC0.18828819
151PRKG10.18591596
152FYN0.18359519
153PAK20.18294271
154ERBB40.15669772
155PRKCQ0.15375541
156TAF10.15257102

Predicted pathways (KEGG)

RankGene SetZ-score
1Phototransduction_Homo sapiens_hsa0474415.9432457
2Synaptic vesicle cycle_Homo sapiens_hsa047211.53694811
3Vitamin digestion and absorption_Homo sapiens_hsa049771.50904537
4Olfactory transduction_Homo sapiens_hsa047401.50519272
5Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.28740283
6Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.20316507
7GABAergic synapse_Homo sapiens_hsa047271.14705144
8Fatty acid biosynthesis_Homo sapiens_hsa000611.14131922
9alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.04923655
10Butanoate metabolism_Homo sapiens_hsa006501.01418373
11Linoleic acid metabolism_Homo sapiens_hsa005910.98914762
12Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.93107897
13Ether lipid metabolism_Homo sapiens_hsa005650.91655168
14Cholinergic synapse_Homo sapiens_hsa047250.86039374
15Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.85620624
16Morphine addiction_Homo sapiens_hsa050320.85197462
17Retinol metabolism_Homo sapiens_hsa008300.83425633
18Glutamatergic synapse_Homo sapiens_hsa047240.82654874
19Fat digestion and absorption_Homo sapiens_hsa049750.82611725
20Complement and coagulation cascades_Homo sapiens_hsa046100.82582361
21Circadian rhythm_Homo sapiens_hsa047100.80668977
22Circadian entrainment_Homo sapiens_hsa047130.78398608
23Dopaminergic synapse_Homo sapiens_hsa047280.76153139
24Arginine and proline metabolism_Homo sapiens_hsa003300.75750597
25Maturity onset diabetes of the young_Homo sapiens_hsa049500.74384292
26Caffeine metabolism_Homo sapiens_hsa002320.71704250
27Serotonergic synapse_Homo sapiens_hsa047260.70018626
28PPAR signaling pathway_Homo sapiens_hsa033200.65774046
29Sulfur metabolism_Homo sapiens_hsa009200.64606020
30ABC transporters_Homo sapiens_hsa020100.64168245
31Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.63616237
32Nicotine addiction_Homo sapiens_hsa050330.61570907
33Insulin secretion_Homo sapiens_hsa049110.59220690
34Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.58784564
35Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.58750360
36Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.54884457
37cGMP-PKG signaling pathway_Homo sapiens_hsa040220.54821107
38Primary bile acid biosynthesis_Homo sapiens_hsa001200.53119630
39Chemical carcinogenesis_Homo sapiens_hsa052040.53110077
40Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.52550606
41Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.52467784
42Cysteine and methionine metabolism_Homo sapiens_hsa002700.51467738
43Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.49770932
44Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.49272122
45Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.48021195
46Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.46758694
47Nitrogen metabolism_Homo sapiens_hsa009100.45641718
48Oxytocin signaling pathway_Homo sapiens_hsa049210.45525236
49Purine metabolism_Homo sapiens_hsa002300.44744261
50Phosphatidylinositol signaling system_Homo sapiens_hsa040700.44210972
51Tryptophan metabolism_Homo sapiens_hsa003800.44093967
52One carbon pool by folate_Homo sapiens_hsa006700.43583441
53Selenocompound metabolism_Homo sapiens_hsa004500.41474035
54Sphingolipid metabolism_Homo sapiens_hsa006000.41132849
55ECM-receptor interaction_Homo sapiens_hsa045120.39926644
56cAMP signaling pathway_Homo sapiens_hsa040240.39224555
57Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.39145981
58Tyrosine metabolism_Homo sapiens_hsa003500.38918976
59Phenylalanine metabolism_Homo sapiens_hsa003600.38758741
60Melanoma_Homo sapiens_hsa052180.38557754
61Estrogen signaling pathway_Homo sapiens_hsa049150.38113160
62Aldosterone synthesis and secretion_Homo sapiens_hsa049250.37916234
63Salivary secretion_Homo sapiens_hsa049700.37430970
64Cyanoamino acid metabolism_Homo sapiens_hsa004600.37273293
65Histidine metabolism_Homo sapiens_hsa003400.36504131
66Arachidonic acid metabolism_Homo sapiens_hsa005900.36032458
67Dilated cardiomyopathy_Homo sapiens_hsa054140.35839597
68TGF-beta signaling pathway_Homo sapiens_hsa043500.35681138
69Renin secretion_Homo sapiens_hsa049240.35108939
70Carbohydrate digestion and absorption_Homo sapiens_hsa049730.33827277
71Inositol phosphate metabolism_Homo sapiens_hsa005620.33547809
72Gastric acid secretion_Homo sapiens_hsa049710.33188122
73Vibrio cholerae infection_Homo sapiens_hsa051100.32988859
74Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.32886747
75Long-term potentiation_Homo sapiens_hsa047200.32514976
76Cocaine addiction_Homo sapiens_hsa050300.31214875
77Adherens junction_Homo sapiens_hsa045200.30965298
78Regulation of autophagy_Homo sapiens_hsa041400.29443135
79Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.28911675
80Thyroid hormone signaling pathway_Homo sapiens_hsa049190.28710896
81Cardiac muscle contraction_Homo sapiens_hsa042600.28375614
82Calcium signaling pathway_Homo sapiens_hsa040200.27069559
83SNARE interactions in vesicular transport_Homo sapiens_hsa041300.27017464
84Fatty acid elongation_Homo sapiens_hsa000620.27004287
85Glycerolipid metabolism_Homo sapiens_hsa005610.26869239
86Steroid hormone biosynthesis_Homo sapiens_hsa001400.26675658
87Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.26614330
88Thyroid cancer_Homo sapiens_hsa052160.26163786
89mTOR signaling pathway_Homo sapiens_hsa041500.25977482
90Protein digestion and absorption_Homo sapiens_hsa049740.25307729
91Glutathione metabolism_Homo sapiens_hsa004800.25290335
92Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.24374522
93Amphetamine addiction_Homo sapiens_hsa050310.24340137
94Glycerophospholipid metabolism_Homo sapiens_hsa005640.23964191
95Propanoate metabolism_Homo sapiens_hsa006400.23856557
96Fructose and mannose metabolism_Homo sapiens_hsa000510.23549256
972-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.23520256
98Type II diabetes mellitus_Homo sapiens_hsa049300.22658850
99Chemokine signaling pathway_Homo sapiens_hsa040620.22200055
100Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.21355004
101Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.21013101
102Lysine degradation_Homo sapiens_hsa003100.20897905
103Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.20707513
104Arginine biosynthesis_Homo sapiens_hsa002200.20259875
105Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.20088186
106Dorso-ventral axis formation_Homo sapiens_hsa043200.19543958
107Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.18185036
108Glucagon signaling pathway_Homo sapiens_hsa049220.17813275
109Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.17143800
110Taste transduction_Homo sapiens_hsa047420.16565335
111HIF-1 signaling pathway_Homo sapiens_hsa040660.15365331
112Ras signaling pathway_Homo sapiens_hsa040140.15256526
113Pancreatic secretion_Homo sapiens_hsa049720.14476195
114MAPK signaling pathway_Homo sapiens_hsa040100.14134620
115Longevity regulating pathway - mammal_Homo sapiens_hsa042110.13944205
116Drug metabolism - other enzymes_Homo sapiens_hsa009830.13811243
117Vascular smooth muscle contraction_Homo sapiens_hsa042700.13614160
118Central carbon metabolism in cancer_Homo sapiens_hsa052300.13609916
119Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.13475209
120GnRH signaling pathway_Homo sapiens_hsa049120.13450824
121Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.12356302
122Alcoholism_Homo sapiens_hsa050340.12318596
123Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.11442982
124Collecting duct acid secretion_Homo sapiens_hsa049660.11320969
125Bile secretion_Homo sapiens_hsa049760.09945290
126Phospholipase D signaling pathway_Homo sapiens_hsa040720.09486764
127Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.09398350
128AMPK signaling pathway_Homo sapiens_hsa041520.09308598
129Mineral absorption_Homo sapiens_hsa049780.08722009
130Tight junction_Homo sapiens_hsa045300.08537087
131Choline metabolism in cancer_Homo sapiens_hsa052310.07638838
132Wnt signaling pathway_Homo sapiens_hsa043100.07534630
133Thyroid hormone synthesis_Homo sapiens_hsa049180.07450762
134Glioma_Homo sapiens_hsa052140.07201698
135Ovarian steroidogenesis_Homo sapiens_hsa049130.06917177
136Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.06529810
137ErbB signaling pathway_Homo sapiens_hsa040120.06126449
138Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.05536773
139Axon guidance_Homo sapiens_hsa043600.05030360
140Adipocytokine signaling pathway_Homo sapiens_hsa049200.04021476
141Melanogenesis_Homo sapiens_hsa049160.03843402
142Galactose metabolism_Homo sapiens_hsa000520.03806578
143Long-term depression_Homo sapiens_hsa047300.03459063
144Insulin resistance_Homo sapiens_hsa049310.02959369
145Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.02883037
146Endocytosis_Homo sapiens_hsa041440.02826611
147Hippo signaling pathway_Homo sapiens_hsa043900.01924395
148mRNA surveillance pathway_Homo sapiens_hsa030150.01919734

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