IMPG2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene binds chondroitin sulfate and hyaluronan and is a proteoglycan. The encoded protein plays a role in the organization of the interphotoreceptor matrix and may promote the growth and maintenance of the light-sensitive photoreceptor outer segment. Defects in this gene are a cause of retinitis pigmentosa type 56 and maculopathy, IMPG2-related. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1phototransduction, visible light (GO:0007603)9.98517908
2detection of light stimulus (GO:0009583)9.80696532
3detection of visible light (GO:0009584)9.56088171
4protein-chromophore linkage (GO:0018298)9.03360261
5GMP metabolic process (GO:0046037)8.83464880
6* visual perception (GO:0007601)8.66560461
7* sensory perception of light stimulus (GO:0050953)8.56796944
8photoreceptor cell differentiation (GO:0046530)7.75743863
9eye photoreceptor cell differentiation (GO:0001754)7.75743863
10positive regulation of guanylate cyclase activity (GO:0031284)7.31099706
11detection of external stimulus (GO:0009581)6.86482939
12detection of abiotic stimulus (GO:0009582)6.73101487
13cellular response to light stimulus (GO:0071482)6.60858289
14retina development in camera-type eye (GO:0060041)6.60068362
15regulation of guanylate cyclase activity (GO:0031282)6.54815020
16negative regulation of astrocyte differentiation (GO:0048712)6.36839214
17regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)5.84984592
18regulation of mitotic spindle checkpoint (GO:1903504)5.84984592
19positive regulation of cell cycle checkpoint (GO:1901978)5.63465203
20peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)5.47631189
21regulation of inhibitory postsynaptic membrane potential (GO:0060080)5.07444386
22regulation of cGMP metabolic process (GO:0030823)4.89260420
23estrogen biosynthetic process (GO:0006703)4.67965068
24nonmotile primary cilium assembly (GO:0035058)4.67050955
25regulation of clathrin-mediated endocytosis (GO:2000369)4.59042760
26positive regulation of cGMP biosynthetic process (GO:0030828)4.51706012
27detection of chemical stimulus involved in sensory perception of bitter taste (GO:0001580)4.41442633
28cellular response to radiation (GO:0071478)4.23762900
29positive regulation of gastrulation (GO:2000543)4.21752933
30regulation of cGMP biosynthetic process (GO:0030826)4.20609464
31adaptation of signaling pathway (GO:0023058)4.19452042
32negative regulation of reactive oxygen species metabolic process (GO:2000378)4.16222385
33regulation of mRNA catabolic process (GO:0061013)4.10860670
34* sensory perception (GO:0007600)4.06101154
35spinal cord association neuron differentiation (GO:0021527)4.01622234
36positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.99699172
37retina layer formation (GO:0010842)3.96532952
38positive regulation of cGMP metabolic process (GO:0030825)3.94171928
39regulation of short-term neuronal synaptic plasticity (GO:0048172)3.90529200
40neuron development (GO:0048666)3.82671140
41response to light stimulus (GO:0009416)3.78563525
42nephron epithelium morphogenesis (GO:0072088)3.76704974
43nephron tubule morphogenesis (GO:0072078)3.76704974
44regulation of G-protein coupled receptor protein signaling pathway (GO:0008277)3.73093085
45behavioral response to nicotine (GO:0035095)3.67325812
46neuron fate determination (GO:0048664)3.63535445
47negative regulation of receptor-mediated endocytosis (GO:0048261)3.56421160
48negative regulation of glial cell differentiation (GO:0045686)3.50832062
49G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.49638045
50cell morphogenesis involved in neuron differentiation (GO:0048667)3.48557265
51somite rostral/caudal axis specification (GO:0032525)3.45810012
52positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.45422571
53receptor guanylyl cyclase signaling pathway (GO:0007168)3.44411513
54L-glutamate transport (GO:0015813)3.41778301
55retinoid metabolic process (GO:0001523)3.41705909
56neuroblast proliferation (GO:0007405)3.39916976
57cell differentiation involved in metanephros development (GO:0072202)3.37231215
58negative regulation of cytosolic calcium ion concentration (GO:0051481)3.28111875
59regulation of astrocyte differentiation (GO:0048710)3.25466683
60acidic amino acid transport (GO:0015800)3.24459108
61diterpenoid metabolic process (GO:0016101)3.20335792
62axoneme assembly (GO:0035082)3.19231114
63RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.15462943
64tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.15462943
65pyrimidine nucleobase catabolic process (GO:0006208)3.14642017
66retina homeostasis (GO:0001895)3.12357587
67regulation of voltage-gated calcium channel activity (GO:1901385)3.10887296
68double-strand break repair via homologous recombination (GO:0000724)3.09654100
69epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.09592489
70recombinational repair (GO:0000725)3.06178088
71primitive streak formation (GO:0090009)3.06154222
72lipoprotein transport (GO:0042953)3.05335683
73synaptic vesicle docking involved in exocytosis (GO:0016081)3.03518100
74synaptic vesicle maturation (GO:0016188)3.02171244
75cell differentiation in spinal cord (GO:0021515)3.00500721
76CDP-diacylglycerol biosynthetic process (GO:0016024)2.99979143
77protein prenylation (GO:0018342)2.96552344
78prenylation (GO:0097354)2.96552344
79terpenoid metabolic process (GO:0006721)2.96253987
80limb development (GO:0060173)2.94419438
81appendage development (GO:0048736)2.94419438
82renal tubule morphogenesis (GO:0061333)2.93716299
83protein localization to synapse (GO:0035418)2.92796273
84negative regulation of gliogenesis (GO:0014014)2.91490617
85regulation of myelination (GO:0031641)2.91080776
86protein K11-linked deubiquitination (GO:0035871)2.90858966
87negative regulation of neurotransmitter transport (GO:0051589)2.88282255
88L-fucose catabolic process (GO:0042355)2.85822282
89fucose catabolic process (GO:0019317)2.85822282
90L-fucose metabolic process (GO:0042354)2.85822282
91phospholipid translocation (GO:0045332)2.85281977
92lipid translocation (GO:0034204)2.85281977
93motor neuron axon guidance (GO:0008045)2.83619633
94cartilage condensation (GO:0001502)2.81630809
95cell aggregation (GO:0098743)2.81630809
96regulation of spindle checkpoint (GO:0090231)2.81517186
97positive regulation of G-protein coupled receptor protein signaling pathway (GO:0045745)2.78637318
98membrane hyperpolarization (GO:0060081)2.78564540
99pancreas development (GO:0031016)2.78286763
100neuron remodeling (GO:0016322)2.77299521
101retinol metabolic process (GO:0042572)2.77292430
102response to pheromone (GO:0019236)2.75692653
103proline transport (GO:0015824)2.75507166
104pituitary gland development (GO:0021983)2.70565710
105inner ear receptor cell differentiation (GO:0060113)2.68739700
106positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.68386224
107positive regulation of neurotransmitter transport (GO:0051590)2.67627761
108negative regulation of transcription regulatory region DNA binding (GO:2000678)2.67044686
109neuron fate specification (GO:0048665)2.66665921
110CDP-diacylglycerol metabolic process (GO:0046341)2.65943198
111glomerulus development (GO:0032835)2.65766363
112positive regulation of vesicle fusion (GO:0031340)2.65718888
113regulation of neurotransmitter uptake (GO:0051580)2.65688063
114nucleobase catabolic process (GO:0046113)2.65378926
115histone H3-K9 methylation (GO:0051567)2.64718647
116retinoic acid receptor signaling pathway (GO:0048384)2.64546477
117regulation of centrosome duplication (GO:0010824)2.62225893
118fatty acid elongation (GO:0030497)2.57216662
119response to radiation (GO:0009314)2.56458417
120negative regulation of peptidyl-threonine phosphorylation (GO:0010801)2.54905321
121skeletal muscle tissue regeneration (GO:0043403)2.51647262
122positive regulation of sodium ion transmembrane transport (GO:1902307)2.51322582
123startle response (GO:0001964)2.49134442
124axonal fasciculation (GO:0007413)2.49065567
125tryptophan catabolic process (GO:0006569)2.48270673
126indole-containing compound catabolic process (GO:0042436)2.48270673
127indolalkylamine catabolic process (GO:0046218)2.48270673
128exogenous drug catabolic process (GO:0042738)2.46972304
129detection of chemical stimulus involved in sensory perception of taste (GO:0050912)2.46790450
130short-term memory (GO:0007614)2.45318543
131atrial cardiac muscle cell action potential (GO:0086014)2.44596620
132indolalkylamine metabolic process (GO:0006586)2.44026150
133protein heterotetramerization (GO:0051290)2.42254713
134lactate metabolic process (GO:0006089)2.41631587
135behavioral response to ethanol (GO:0048149)2.41449704
136cellular potassium ion homeostasis (GO:0030007)2.40250582
137isoprenoid metabolic process (GO:0006720)2.38849341
138positive regulation of sodium ion transmembrane transporter activity (GO:2000651)2.38332571
139positive regulation of epidermal growth factor receptor signaling pathway (GO:0045742)2.34879332
140righting reflex (GO:0060013)2.34867107
141chemosensory behavior (GO:0007635)2.32574697
142response to histamine (GO:0034776)2.30257433
143detection of chemical stimulus involved in sensory perception (GO:0050907)2.26882088
144hypothalamus development (GO:0021854)2.23865578
145vitamin A metabolic process (GO:0006776)2.21972877
146phospholipid transport (GO:0015914)2.20692962
147regulation of penile erection (GO:0060405)2.20324382
148epithelial cell differentiation involved in kidney development (GO:0035850)2.19450521
149sodium ion export (GO:0071436)2.18913473
150histone H3-K4 trimethylation (GO:0080182)2.15798635
151positive regulation of ERBB signaling pathway (GO:1901186)2.15686537
152regulation of rhodopsin mediated signaling pathway (GO:0022400)15.7530024
153rhodopsin mediated signaling pathway (GO:0016056)15.3164277
154retinal cone cell development (GO:0046549)14.8880735
155photoreceptor cell maintenance (GO:0045494)12.7933820
156photoreceptor cell development (GO:0042461)12.7283115
157eye photoreceptor cell development (GO:0042462)12.0915340
158retinal rod cell development (GO:0046548)11.8274236
159phototransduction (GO:0007602)10.3723593
160detection of light stimulus involved in visual perception (GO:0050908)10.3298174
161detection of light stimulus involved in sensory perception (GO:0050962)10.3298174

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.08386515
2FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.00807530
3EZH2_22144423_ChIP-Seq_EOC_Human3.42772266
4CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse3.37735435
5GBX2_23144817_ChIP-Seq_PC3_Human3.25208550
6GATA1_22025678_ChIP-Seq_K562_Human3.21731819
7HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.79302430
8GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.79234237
9CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.34987588
10ZFP57_27257070_Chip-Seq_ESCs_Mouse2.32782480
11FLI1_27457419_Chip-Seq_LIVER_Mouse2.28817199
12SUZ12_27294783_Chip-Seq_NPCs_Mouse2.24508111
13FUS_26573619_Chip-Seq_HEK293_Human2.10961527
14ZNF274_21170338_ChIP-Seq_K562_Hela2.10437488
15NFE2_27457419_Chip-Seq_LIVER_Mouse2.07430714
16SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.03750522
17VDR_22108803_ChIP-Seq_LS180_Human1.99812089
18DROSHA_22980978_ChIP-Seq_HELA_Human1.97499582
19PCGF2_27294783_Chip-Seq_ESCs_Mouse1.97300156
20SALL1_21062744_ChIP-ChIP_HESCs_Human1.88856640
21DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.87723558
22EZH2_27294783_Chip-Seq_NPCs_Mouse1.85261945
23* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.84383880
24CBX2_22325352_ChIP-Seq_293T-Rex_Human1.78997301
25EWS_26573619_Chip-Seq_HEK293_Human1.78895801
26PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.78481951
27* ETV1_20927104_ChIP-Seq_GIST48_Human1.78474062
28TAF15_26573619_Chip-Seq_HEK293_Human1.75696988
29SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.70338982
30EZH2_27294783_Chip-Seq_ESCs_Mouse1.69872253
31BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.65990095
32STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.64616219
33SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.62919781
34P53_22127205_ChIP-Seq_FIBROBLAST_Human1.61601454
35TCF4_18268006_ChIP-ChIP_LS174T_Human1.61403668
36AR_21572438_ChIP-Seq_LNCaP_Human1.61313965
37GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.59717671
38SUZ12_27294783_Chip-Seq_ESCs_Mouse1.59527383
39EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.58764940
40TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.57686912
41REST_21632747_ChIP-Seq_MESCs_Mouse1.57002370
42CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.56858909
43NFYB_21822215_ChIP-Seq_K562_Human1.56476076
44RBPJ_21746931_ChIP-Seq_IB4_Human1.53765524
45MTF2_20144788_ChIP-Seq_MESCs_Mouse1.52442405
46* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.51244982
47P53_22387025_ChIP-Seq_ESCs_Mouse1.50802783
48SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.50186812
49PHF8_20622853_ChIP-Seq_HELA_Human1.48458711
50NR3C1_21868756_ChIP-Seq_MCF10A_Human1.47959027
51NFYA_21822215_ChIP-Seq_K562_Human1.47201043
52PCGF2_27294783_Chip-Seq_NPCs_Mouse1.46672264
53* SMAD3_21741376_ChIP-Seq_HESCs_Human1.45837291
54REST_18959480_ChIP-ChIP_MESCs_Mouse1.45699561
55SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.45426999
56* SMAD4_21799915_ChIP-Seq_A2780_Human1.44208419
57EZH2_18974828_ChIP-Seq_MESCs_Mouse1.43988736
58RNF2_18974828_ChIP-Seq_MESCs_Mouse1.43988736
59BCAT_22108803_ChIP-Seq_LS180_Human1.42089372
60KDM2B_26808549_Chip-Seq_K562_Human1.40718457
61* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.40057365
62EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.39175391
63* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.38982249
64* AR_19668381_ChIP-Seq_PC3_Human1.38611467
65JARID2_20075857_ChIP-Seq_MESCs_Mouse1.37829874
66TBL1_22424771_ChIP-Seq_293T_Human1.34889714
67CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.34160694
68RARB_27405468_Chip-Seq_BRAIN_Mouse1.33830357
69* CBP_20019798_ChIP-Seq_JUKART_Human1.33555590
70* IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.33555590
71RING1B_27294783_Chip-Seq_NPCs_Mouse1.32935770
72CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.32730937
73E2F1_18555785_Chip-Seq_ESCs_Mouse1.31405757
74P300_19829295_ChIP-Seq_ESCs_Human1.31212878
75EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.31176641
76TOP2B_26459242_ChIP-Seq_MCF-7_Human1.30770832
77CMYC_18555785_Chip-Seq_ESCs_Mouse1.30122103
78AR_25329375_ChIP-Seq_VCAP_Human1.29951177
79HNFA_21074721_ChIP-Seq_CACO-2_Human1.29119805
80* STAT3_23295773_ChIP-Seq_U87_Human1.28316945
81IGF1R_20145208_ChIP-Seq_DFB_Human1.26756562
82CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.26110294
83SUZ12_18555785_Chip-Seq_ESCs_Mouse1.25844008
84CRX_20693478_ChIP-Seq_RETINA_Mouse1.25622670
85RNF2_27304074_Chip-Seq_ESCs_Mouse1.25595583
86GATA6_21074721_ChIP-Seq_CACO-2_Human1.21672110
87KDM2B_26808549_Chip-Seq_REH_Human1.19967930
88WDR5_24793694_ChIP-Seq_LNCAP_Human1.19358395
89EZH2_27304074_Chip-Seq_ESCs_Mouse1.18862187
90OCT4_21477851_ChIP-Seq_ESCs_Mouse1.18840320
91* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.18761264
92POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.17779887
93TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.17779887
94ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.17698015
95GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.17273088
96E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.15727790
97ISL1_27105846_Chip-Seq_CPCs_Mouse1.15462496
98RUNX2_22187159_ChIP-Seq_PCA_Human1.14877348
99SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.14484320
100SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.14311114
101RXR_22108803_ChIP-Seq_LS180_Human1.13449464
102BMI1_23680149_ChIP-Seq_NPCS_Mouse1.13302618
103SMAD4_21741376_ChIP-Seq_HESCs_Human1.12221770
104TCF4_22108803_ChIP-Seq_LS180_Human1.11610299
105OCT4_18555785_Chip-Seq_ESCs_Mouse1.11399338
106OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.09754682
107RUNX1_27457419_Chip-Seq_LIVER_Mouse1.09317655
108CTCF_27219007_Chip-Seq_Bcells_Human1.09171846
109YAP1_20516196_ChIP-Seq_MESCs_Mouse1.07636649
110CTBP2_25329375_ChIP-Seq_LNCAP_Human1.07625694
111RNF2_27304074_Chip-Seq_NSC_Mouse1.07604511
112STAT3_18555785_Chip-Seq_ESCs_Mouse1.07145635
113FLI1_21867929_ChIP-Seq_TH2_Mouse1.07139678
114P300_18555785_Chip-Seq_ESCs_Mouse1.07058960
115NMYC_18555785_Chip-Seq_ESCs_Mouse1.06650590
116CDX2_22108803_ChIP-Seq_LS180_Human1.06643416
117ER_23166858_ChIP-Seq_MCF-7_Human1.06518424
118RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.06213756
119SOX2_18555785_Chip-Seq_ESCs_Mouse1.06117191
120ERG_21242973_ChIP-ChIP_JURKAT_Human1.05779646
121ZNF217_24962896_ChIP-Seq_MCF-7_Human1.03868277
122CTBP1_25329375_ChIP-Seq_LNCAP_Human1.03554634
123* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.03044361
124TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.01240591
125NANOG_18555785_Chip-Seq_ESCs_Mouse1.00593961
126NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.00367315
127AHR_22903824_ChIP-Seq_MCF-7_Human0.99899843
128EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.99832998
129* TCF4_23295773_ChIP-Seq_U87_Human0.99612710
130PRDM14_20953172_ChIP-Seq_ESCs_Human0.99488593
131PIAS1_25552417_ChIP-Seq_VCAP_Human0.99017721
132DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.98884697
133RXR_22158963_ChIP-Seq_LIVER_Mouse0.97867672
134CBP_21632823_ChIP-Seq_H3396_Human0.97725135
135JARID2_20064375_ChIP-Seq_MESCs_Mouse0.97364737
136SMC4_20622854_ChIP-Seq_HELA_Human0.96228748
137ARNT_22903824_ChIP-Seq_MCF-7_Human0.95933495
138GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.95617094
139SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.94873935
140SMAD3_21741376_ChIP-Seq_EPCs_Human0.94561421
141ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.93284036
142SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.92633639
143KDM2B_26808549_Chip-Seq_JURKAT_Human0.91210162
144BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.90326006
145FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.89841526
146GF1_26923725_Chip-Seq_HPCs_Mouse0.89511134
147SOX2_21211035_ChIP-Seq_LN229_Gbm0.89489561
148NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.89386819
149EED_16625203_ChIP-ChIP_MESCs_Mouse0.89189015
150CBX2_27304074_Chip-Seq_ESCs_Mouse0.88865453
151* EP300_21415370_ChIP-Seq_HL-1_Mouse0.88426231
152TAF2_19829295_ChIP-Seq_ESCs_Human0.88325441
153TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.87640348
154CDX2_19796622_ChIP-Seq_MESCs_Mouse0.87291928
155OCT1_27270436_Chip-Seq_PROSTATE_Human0.86712161
156GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.86461260
157WT1_25993318_ChIP-Seq_PODOCYTE_Human0.86354893
158PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.85464752
159SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.85243018

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005551_abnormal_eye_electrophysiolog9.59781957
2MP0002822_catalepsy8.75326027
3MP0005253_abnormal_eye_physiology6.83975775
4MP0006072_abnormal_retinal_apoptosis6.62728570
5MP0005195_abnormal_posterior_eye4.08516756
6MP0001324_abnormal_eye_pigmentation3.75528141
7MP0005391_vision/eye_phenotype3.48333994
8MP0003950_abnormal_plasma_membrane3.01083581
9MP0002090_abnormal_vision2.72061248
10MP0002229_neurodegeneration2.63162728
11MP0003646_muscle_fatigue2.62382204
12MP0002638_abnormal_pupillary_reflex2.39774865
13MP0002653_abnormal_ependyma_morphology2.38948080
14MP0006292_abnormal_olfactory_placode2.01353198
15MP0003011_delayed_dark_adaptation10.4779946
16MP0002752_abnormal_somatic_nervous1.98073555
17MP0003567_abnormal_fetal_cardiomyocyte1.95814774
18MP0001502_abnormal_circadian_rhythm1.90906905
19MP0005423_abnormal_somatic_nervous1.85830297
20MP0001764_abnormal_homeostasis1.81781770
21MP0005645_abnormal_hypothalamus_physiol1.68533150
22MP0002102_abnormal_ear_morphology1.66420294
23MP0003878_abnormal_ear_physiology1.49728147
24MP0005377_hearing/vestibular/ear_phenot1.49728147
25MP0006276_abnormal_autonomic_nervous1.46288850
26MP0004885_abnormal_endolymph1.41465117
27MP0001919_abnormal_reproductive_system1.40692395
28MP0002882_abnormal_neuron_morphology1.38849862
29MP0004036_abnormal_muscle_relaxation1.38317041
30MP0004019_abnormal_vitamin_homeostasis1.36616753
31MP0002735_abnormal_chemical_nociception1.36463557
32MP0004043_abnormal_pH_regulation1.35559977
33MP0000569_abnormal_digit_pigmentation1.32785885
34MP0001501_abnormal_sleep_pattern1.31804330
35MP0005499_abnormal_olfactory_system1.31035633
36MP0005394_taste/olfaction_phenotype1.31035633
37MP0008789_abnormal_olfactory_epithelium1.25272648
38MP0003879_abnormal_hair_cell1.23143500
39MP0008057_abnormal_DNA_replication1.21734206
40MP0001986_abnormal_taste_sensitivity1.21033567
41MP0006138_congestive_heart_failure1.08845671
42MP0003195_calcinosis1.06745099
43MP0000383_abnormal_hair_follicle1.05030805
44MP0005197_abnormal_uvea_morphology1.04524542
45MP0008872_abnormal_physiological_respon1.04214616
46MP0001984_abnormal_olfaction1.02430509
47MP0010030_abnormal_orbit_morphology1.01737168
48MP0005167_abnormal_blood-brain_barrier1.00907916
49MP0005389_reproductive_system_phenotype1.00089041
50MP0000566_synostosis0.96040210
51MP0000955_abnormal_spinal_cord0.95760051
52MP0005647_abnormal_sex_gland0.93377065
53MP0003890_abnormal_embryonic-extraembry0.92015264
54MP0005248_abnormal_Harderian_gland0.90675800
55MP0008877_abnormal_DNA_methylation0.88073445
56MP0002127_abnormal_cardiovascular_syste0.86066934
57MP0002909_abnormal_adrenal_gland0.83341859
58MP0004233_abnormal_muscle_weight0.83314567
59MP0002876_abnormal_thyroid_physiology0.82580507
60MP0001486_abnormal_startle_reflex0.82204145
61MP0002009_preneoplasia0.81148292
62MP0004270_analgesia0.80759215
63MP0002160_abnormal_reproductive_system0.80597290
64MP0001485_abnormal_pinna_reflex0.78588662
65MP0001286_abnormal_eye_development0.77700894
66MP0008058_abnormal_DNA_repair0.76354785
67MP0004145_abnormal_muscle_electrophysio0.75013331
68MP0003045_fibrosis0.74280649
69MP0002751_abnormal_autonomic_nervous0.74123966
70MP0005187_abnormal_penis_morphology0.73331814
71MP0003634_abnormal_glial_cell0.72997487
72MP0002736_abnormal_nociception_after0.72835730
73MP0005365_abnormal_bile_salt0.69150431
74MP0002234_abnormal_pharynx_morphology0.68742638
75MP0000470_abnormal_stomach_morphology0.68599572
76MP0001440_abnormal_grooming_behavior0.68106387
77MP0002233_abnormal_nose_morphology0.66290559
78MP0002837_dystrophic_cardiac_calcinosis0.64316166
79MP0003119_abnormal_digestive_system0.64069458
80MP0001970_abnormal_pain_threshold0.60796233
81MP0002272_abnormal_nervous_system0.60458472
82MP0002697_abnormal_eye_size0.59226100
83MP0003880_abnormal_central_pattern0.58906816
84MP0001293_anophthalmia0.58415167
85MP0000465_gastrointestinal_hemorrhage0.56632841
86MP0002064_seizures0.54457822
87MP0003252_abnormal_bile_duct0.53127097
88MP0005360_urolithiasis0.51843843
89MP0001963_abnormal_hearing_physiology0.50512075
90MP0010386_abnormal_urinary_bladder0.50174963
91MP0002332_abnormal_exercise_endurance0.49900240
92MP0004782_abnormal_surfactant_physiolog0.49728049
93MP0003635_abnormal_synaptic_transmissio0.49514905
94MP0002734_abnormal_mechanical_nocicepti0.47965336
95MP0000631_abnormal_neuroendocrine_gland0.47921638
96MP0002139_abnormal_hepatobiliary_system0.44691018
97MP0002067_abnormal_sensory_capabilities0.43101987
98MP0009780_abnormal_chondrocyte_physiolo0.42275475
99MP0005386_behavior/neurological_phenoty0.40849913
100MP0004924_abnormal_behavior0.40849913
101MP0002063_abnormal_learning/memory/cond0.40630546
102MP0000778_abnormal_nervous_system0.40591293
103MP0004859_abnormal_synaptic_plasticity0.40199782
104MP0008875_abnormal_xenobiotic_pharmacok0.36741735
105MP0009046_muscle_twitch0.36536032
106MP0005193_abnormal_anterior_eye0.35371210
107MP0002572_abnormal_emotion/affect_behav0.35171631
108MP0001915_intracranial_hemorrhage0.34628562
109MP0002092_abnormal_eye_morphology0.33566998
110MP0009745_abnormal_behavioral_response0.32757773
111MP0005085_abnormal_gallbladder_physiolo0.32311381
112MP0001346_abnormal_lacrimal_gland0.31704169
113MP0004742_abnormal_vestibular_system0.30774362
114MP0010329_abnormal_lipoprotein_level0.30764104
115MP0003633_abnormal_nervous_system0.30741449
116MP0005646_abnormal_pituitary_gland0.30590922
117MP0005376_homeostasis/metabolism_phenot0.30149387
118MP0002152_abnormal_brain_morphology0.29758347
119MP0008004_abnormal_stomach_pH0.29527413
120MP0003787_abnormal_imprinting0.28520085
121MP0002184_abnormal_innervation0.28459380
122MP0001968_abnormal_touch/_nociception0.28085228
123MP0002928_abnormal_bile_duct0.26509629
124MP0003943_abnormal_hepatobiliary_system0.26096817
125MP0010368_abnormal_lymphatic_system0.26041453
126MP0005220_abnormal_exocrine_pancreas0.25501497
127MP0004085_abnormal_heartbeat0.25237928
128MP0001879_abnormal_lymphatic_vessel0.25146728
129MP0004215_abnormal_myocardial_fiber0.25084275
130MP0001177_atelectasis0.23947362
131MP0000026_abnormal_inner_ear0.22857658
132MP0002066_abnormal_motor_capabilities/c0.22618882
133MP0003868_abnormal_feces_composition0.21971100
134MP0004811_abnormal_neuron_physiology0.20792764
135MP0005620_abnormal_muscle_contractility0.19554604
136MP0005595_abnormal_vascular_smooth0.19173070
137MP0003632_abnormal_nervous_system0.18997077
138MP0003631_nervous_system_phenotype0.18544919
139MP0004130_abnormal_muscle_cell0.16973085
140MP0002557_abnormal_social/conspecific_i0.16599456
141MP0004142_abnormal_muscle_tone0.16591082
142MP0003861_abnormal_nervous_system0.15016086

Predicted human phenotypes

RankGene SetZ-score
1Pigmentary retinal degeneration (HP:0001146)9.29958940
2Chorioretinal atrophy (HP:0000533)9.29199497
3Central scotoma (HP:0000603)8.96863800
4Dyschromatopsia (HP:0007641)8.77359894
5Pendular nystagmus (HP:0012043)8.53696536
6Abolished electroretinogram (ERG) (HP:0000550)8.32431128
7Abnormality of macular pigmentation (HP:0008002)7.84084953
8Scotoma (HP:0000575)7.83333083
9Intestinal atresia (HP:0011100)6.86657244
10Decreased central vision (HP:0007663)6.40350981
11Attenuation of retinal blood vessels (HP:0007843)6.39780264
12Vitreoretinal degeneration (HP:0000655)6.06800731
13Cone-rod dystrophy (HP:0000548)5.56782648
14Macular degeneration (HP:0000608)5.56114558
15Severe visual impairment (HP:0001141)5.52337430
16Depressed nasal tip (HP:0000437)5.47450052
17Abnormality of the phalanges of the 2nd finger (HP:0009541)5.43983112
18* Type II diabetes mellitus (HP:0005978)5.40878111
19* Photophobia (HP:0000613)5.37751796
20Keratoconus (HP:0000563)5.06268653
21Increased corneal curvature (HP:0100692)5.06268653
22Constricted visual fields (HP:0001133)5.05728681
23Supernumerary spleens (HP:0009799)5.00781618
24Esophageal atresia (HP:0002032)4.91894125
25Annular pancreas (HP:0001734)4.55581411
26Retinitis pigmentosa (HP:0000510)4.06789962
27Asplenia (HP:0001746)4.01129947
28Choroideremia (HP:0001139)3.97515704
29* Posterior subcapsular cataract (HP:0007787)3.92738504
30Aplasia/Hypoplasia of the spleen (HP:0010451)3.82104758
31Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)3.65686317
32Progressive visual loss (HP:0000529)3.51833620
33Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)3.37616442
34Decreased electroretinogram (ERG) amplitude (HP:0000654)3.36997851
35Abnormality of the middle phalanx of the 5th finger (HP:0004219)3.31615226
36Gastrointestinal atresia (HP:0002589)3.26748680
37Abnormality of the 2nd finger (HP:0004100)3.26685365
38Optic nerve hypoplasia (HP:0000609)3.23667082
39Abnormality of the vocal cords (HP:0008777)3.11677152
40Abnormality of the phalanges of the 5th finger (HP:0004213)3.09988983
41Absent septum pellucidum (HP:0001331)2.81267620
42Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.77853016
43Retinal atrophy (HP:0001105)2.72665356
44Congenital sensorineural hearing impairment (HP:0008527)2.59246684
45Abnormality of the septum pellucidum (HP:0007375)2.56302865
46* Wide nasal bridge (HP:0000431)2.37978276
47Growth hormone deficiency (HP:0000824)2.33804272
48Optic disc pallor (HP:0000543)2.32095031
49* Subcapsular cataract (HP:0000523)2.25919410
50Gait imbalance (HP:0002141)2.23303041
51Congenital primary aphakia (HP:0007707)2.22067480
52Aplasia/Hypoplasia affecting the fundus (HP:0008057)2.06660418
53Abnormality of the renal cortex (HP:0011035)2.03598049
54Abnormality of the renal medulla (HP:0100957)2.01081508
55Nephrogenic diabetes insipidus (HP:0009806)2.00940875
56Congenital stationary night blindness (HP:0007642)11.6801285
57Absent rod-and cone-mediated responses on ERG (HP:0007688)11.4059223
58Bony spicule pigmentary retinopathy (HP:0007737)10.6255642
59Abnormal rod and cone electroretinograms (HP:0008323)10.0934785
602-3 toe syndactyly (HP:0004691)1.96762076
61Thyroid-stimulating hormone excess (HP:0002925)1.94092732
62Medial flaring of the eyebrow (HP:0010747)1.89351561
63Tubulointerstitial nephritis (HP:0001970)1.87022201
64Thyroiditis (HP:0100646)1.86645397
65Type II lissencephaly (HP:0007260)1.86283565
66Oligodactyly (hands) (HP:0001180)1.80644451
67Poor coordination (HP:0002370)1.77546398
68Interstitial pulmonary disease (HP:0006530)1.71765975
69True hermaphroditism (HP:0010459)1.71716843
70Severe Myopia (HP:0011003)1.71685151
71Horizontal nystagmus (HP:0000666)1.68059910
72Pancreatic fibrosis (HP:0100732)1.67425884
73Ectopic kidney (HP:0000086)1.63229670
74Abnormality of the duodenum (HP:0002246)1.55586232
75* Optic atrophy (HP:0000648)1.52068209
76Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.51441625
77Abnormality of alanine metabolism (HP:0010916)1.51441625
78Hyperalaninemia (HP:0003348)1.51441625
79Vaginal atresia (HP:0000148)1.51417885
80Genital tract atresia (HP:0001827)1.46140081
81Aplasia/Hypoplasia of the tongue (HP:0010295)1.44672049
82Short palpebral fissure (HP:0012745)1.42597433
83Cystic liver disease (HP:0006706)1.41764221
84Sclerocornea (HP:0000647)1.41530490
85Renal cortical cysts (HP:0000803)1.40101742
86Abnormality of dental color (HP:0011073)1.39836895
87Tubulointerstitial abnormality (HP:0001969)1.31920326
88Aplasia/Hypoplasia of the lens (HP:0008063)1.30594025
89Retinal dysplasia (HP:0007973)1.30593960
90Pancreatic cysts (HP:0001737)1.29967619
91Autoimmune thrombocytopenia (HP:0001973)1.28250894
92Narrow forehead (HP:0000341)1.23737438
93Epileptic encephalopathy (HP:0200134)1.23106011
94Recurrent sinusitis (HP:0011108)1.21069862
95Abnormal drinking behavior (HP:0030082)1.19129449
96Polydipsia (HP:0001959)1.19129449
97Febrile seizures (HP:0002373)1.16090597
98* Polar cataract (HP:0010696)1.15798075
99Dysdiadochokinesis (HP:0002075)1.14035742
100Retinal detachment (HP:0000541)1.07653301
101Astigmatism (HP:0000483)1.06099184
102Chorioretinal coloboma (HP:0000567)1.02852193
103Anophthalmia (HP:0000528)1.02792587
104Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.00792256
105Furrowed tongue (HP:0000221)0.98790538
106Septo-optic dysplasia (HP:0100842)0.98441632
107Abnormality of the fovea (HP:0000493)0.96237234
108Chronic hepatic failure (HP:0100626)0.94823791
109Hypoplasia of the fovea (HP:0007750)0.90220403
110Aplasia/Hypoplasia of the fovea (HP:0008060)0.90220403
111Hypermetropia (HP:0000540)0.87728061
112Specific learning disability (HP:0001328)0.87429219
113Congenital hepatic fibrosis (HP:0002612)0.87350637
114Aplasia/Hypoplasia of the macula (HP:0008059)0.86706188
115Broad foot (HP:0001769)0.85492217
116Left ventricular hypertrophy (HP:0001712)0.84595645
117Abnormality of the fingertips (HP:0001211)0.83908915
118Asthma (HP:0002099)0.81454556
119Truncal ataxia (HP:0002078)0.81446545
120Anencephaly (HP:0002323)0.80610858
121Abnormality of the lower motor neuron (HP:0002366)0.80567226
122Molar tooth sign on MRI (HP:0002419)0.79786551
123Abnormality of midbrain morphology (HP:0002418)0.79786551
124Abdominal situs inversus (HP:0003363)0.79618746
125Abnormality of abdominal situs (HP:0011620)0.79618746
126Aplasia/Hypoplasia affecting the retina (HP:0008061)0.79229416
127Progressive cerebellar ataxia (HP:0002073)0.78800420
128Hyperventilation (HP:0002883)0.78727985
129Decreased testicular size (HP:0008734)0.78640534
130Macroorchidism (HP:0000053)0.75494443
131Visual hallucinations (HP:0002367)0.74975656
132Postaxial foot polydactyly (HP:0001830)0.73809078
133Genetic anticipation (HP:0003743)0.71942355
134Postaxial hand polydactyly (HP:0001162)0.71459990
135Aqueductal stenosis (HP:0002410)0.70279000
136Lymphopenia (HP:0001888)0.67897656
137Short foot (HP:0001773)0.63290400
138Dental crowding (HP:0000678)0.62319101
139Prolonged QT interval (HP:0001657)0.61073883
140Abnormality of cells of the lymphoid lineage (HP:0012140)0.60887764
141Hypodontia (HP:0000668)0.60714956
142Nephronophthisis (HP:0000090)0.60360175
143Hypoventilation (HP:0002791)0.59757651

Predicted kinase interactions (KEA)

RankGene SetZ-score
1GRK19.45210346
2IRAK23.95504654
3ZAK3.86399818
4MAP4K23.61537607
5PINK13.47651288
6MAP3K103.28969516
7PBK3.20250529
8TLK12.93914752
9STK392.66384713
10STK242.63416007
11WNK42.61829458
12SGK2232.23635633
13SGK4942.23635633
14BMPR1B2.08305839
15CAMK1G1.95789496
16CCNB11.94002636
17ADRBK21.89379318
18INSRR1.88346558
19MAPK71.72583997
20CAMK1D1.71109107
21BRD41.65591398
22DAPK21.62528668
23SGK21.58992619
24ADRBK11.54145129
25CDK121.52738140
26CDC71.50816390
27MKNK21.48384233
28ACVR1B1.48235008
29SIK21.47479487
30HIPK21.43090552
31ERBB21.42980487
32MAPK121.41794699
33MAPK131.41009489
34SGK31.40871606
35LATS11.39368731
36PRKCH1.35034300
37ICK1.34663398
38CAMKK21.33753426
39AKT31.33354553
40SIK11.30692363
41MAP3K41.29572607
42WNK31.25544554
43MARK11.20490575
44PIK3CA1.16364947
45CASK1.13306938
46CDK31.11351419
47BCR1.09624376
48TGFBR11.07794341
49VRK11.05658930
50OBSCN1.00595799
51DYRK31.00394922
52PRPF4B1.00237919
53CSNK1D0.98755545
54DYRK1B0.98154639
55TAOK30.96214372
56FGFR20.96079752
57EIF2AK30.95858240
58FRK0.88716553
59TNIK0.88122397
60WNK10.86683033
61STK380.86573397
62TEC0.84570532
63MAP2K70.83329963
64CSNK1G10.82950390
65PASK0.82767053
66RPS6KA40.82688879
67PNCK0.82214789
68DYRK1A0.81733429
69EPHB20.80679537
70RPS6KA50.77633739
71PAK60.77504424
72PRKCZ0.77271492
73NUAK10.76910750
74MAP3K20.76623129
75CHEK20.76458505
76PRKAA10.75954860
77CDK90.75871568
78SGK10.72783722
79PRKCB0.72343994
80TSSK60.71204953
81PRKCQ0.70875000
82OXSR10.70346315
83CAMK40.68317140
84IRAK10.68031275
85TRIM280.67005460
86RPS6KA60.66588832
87MAP2K40.65108120
88ERBB30.65103326
89PRKCE0.64647864
90ILK0.63008188
91CAMKK10.61560139
92CSNK1G30.61324270
93PLK20.61184857
94PRKD30.59471828
95PRKACG0.59250696
96RPS6KA30.59237950
97CAMK2D0.58416336
98CDK190.58060142
99PRKAA20.57422021
100CLK10.56376024
101GSK3B0.55140622
102MKNK10.54328292
103MAPK140.54200956
104KIT0.54195110
105STK38L0.53834697
106SRPK10.53455316
107NTRK20.53134723
108BTK0.52309376
109NEK10.51721200
110PTK2B0.50699284
111TXK0.50281770
112STK40.50180290
113DYRK20.48492590
114STK110.48267026
115GSK3A0.47990552
116MAPK90.47463936
117CDK50.47379597
118CSNK1A1L0.46862736
119MAP3K70.46282919
120MAPK100.46112199
121CAMK10.45486635
122TIE10.43953134
123CAMK2A0.43888240
124PLK30.43071783
125PRKCI0.42364448
126CDK10.42060757
127RET0.41741901
128SIK30.41633548
129STK30.40721792
130SCYL20.40589549
131FLT30.39798191
132PLK40.39388049
133PIM10.39342273
134JAK30.39251107
135RPS6KC10.39156957
136RPS6KL10.39156957
137PAK30.38776647
138PRKD20.38718675
139FGFR30.37833347
140MUSK0.36969389
141MAPKAPK30.36700499
142JAK10.36497362
143PRKDC0.36329059
144RPS6KB10.35394733
145FGFR10.35353143
146PRKCG0.35342876
147PRKD10.34516681
148PRKACA0.34101196
149PKN10.33172501
150MYLK0.32177046
151YES10.31399827
152MAPK80.31357955
153CHUK0.31220116
154MAPK30.30474447
155CSNK1G20.30052039
156GRK50.29517719
157AKT20.28728983
158ATM0.27723912
159NTRK30.26777617
160MINK10.25215143
161CDC42BPA0.25183971
162MAPK10.24983006

Predicted pathways (KEGG)

RankGene SetZ-score
1Taste transduction_Homo sapiens_hsa047423.72103169
2Systemic lupus erythematosus_Homo sapiens_hsa053222.32569013
3Phototransduction_Homo sapiens_hsa0474415.2813946
4Selenocompound metabolism_Homo sapiens_hsa004501.99432580
5Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.92139400
6Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.89383790
7Butanoate metabolism_Homo sapiens_hsa006501.89082563
8Non-homologous end-joining_Homo sapiens_hsa034501.88043094
9Synaptic vesicle cycle_Homo sapiens_hsa047211.77551770
10Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.71872601
11Olfactory transduction_Homo sapiens_hsa047401.70715783
12Linoleic acid metabolism_Homo sapiens_hsa005911.59904300
13alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.57016477
14Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.27906389
15Basal transcription factors_Homo sapiens_hsa030221.27783890
16GABAergic synapse_Homo sapiens_hsa047271.27158996
17Retinol metabolism_Homo sapiens_hsa008301.25057744
18Ether lipid metabolism_Homo sapiens_hsa005651.18790391
19Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.13780014
20Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.09901527
21Nitrogen metabolism_Homo sapiens_hsa009101.04598063
22Propanoate metabolism_Homo sapiens_hsa006401.02266988
23Circadian rhythm_Homo sapiens_hsa047101.00042308
24Transcriptional misregulation in cancer_Homo sapiens_hsa052020.97358247
25ABC transporters_Homo sapiens_hsa020100.95572908
26Fanconi anemia pathway_Homo sapiens_hsa034600.90764642
27Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.90700607
28Cholinergic synapse_Homo sapiens_hsa047250.90410315
29Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.87509846
30Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.84529639
31One carbon pool by folate_Homo sapiens_hsa006700.84520773
32Circadian entrainment_Homo sapiens_hsa047130.84258073
33Morphine addiction_Homo sapiens_hsa050320.83178318
34Glutamatergic synapse_Homo sapiens_hsa047240.82890312
35Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.82055477
36Regulation of autophagy_Homo sapiens_hsa041400.78562098
37Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.76841878
38Dopaminergic synapse_Homo sapiens_hsa047280.75712070
39Homologous recombination_Homo sapiens_hsa034400.74415814
40Sulfur metabolism_Homo sapiens_hsa009200.71841090
41Intestinal immune network for IgA production_Homo sapiens_hsa046720.71179722
42RNA polymerase_Homo sapiens_hsa030200.70313528
43Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.66780233
44RNA degradation_Homo sapiens_hsa030180.66071656
45Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.64854005
46Axon guidance_Homo sapiens_hsa043600.64773396
47Lysine degradation_Homo sapiens_hsa003100.61413285
48Insulin secretion_Homo sapiens_hsa049110.61031746
49Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.59943544
50Arginine biosynthesis_Homo sapiens_hsa002200.59863455
51Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.59172083
52Caffeine metabolism_Homo sapiens_hsa002320.57549167
53Serotonergic synapse_Homo sapiens_hsa047260.57523086
54Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.56960409
55Maturity onset diabetes of the young_Homo sapiens_hsa049500.56953655
56Thyroid cancer_Homo sapiens_hsa052160.56830434
57Nicotine addiction_Homo sapiens_hsa050330.54832306
58cGMP-PKG signaling pathway_Homo sapiens_hsa040220.54824733
59Fatty acid elongation_Homo sapiens_hsa000620.54777893
60Drug metabolism - other enzymes_Homo sapiens_hsa009830.51061616
61Carbohydrate digestion and absorption_Homo sapiens_hsa049730.51039602
62Primary bile acid biosynthesis_Homo sapiens_hsa001200.50303285
63Primary immunodeficiency_Homo sapiens_hsa053400.47572653
64Asthma_Homo sapiens_hsa053100.45963284
65Vascular smooth muscle contraction_Homo sapiens_hsa042700.44618898
66Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.44150455
67Hedgehog signaling pathway_Homo sapiens_hsa043400.43942024
68Thyroid hormone signaling pathway_Homo sapiens_hsa049190.43542780
69Bile secretion_Homo sapiens_hsa049760.43533200
70Phosphatidylinositol signaling system_Homo sapiens_hsa040700.43112741
71Type I diabetes mellitus_Homo sapiens_hsa049400.42471395
72Glycerolipid metabolism_Homo sapiens_hsa005610.41991193
73mTOR signaling pathway_Homo sapiens_hsa041500.41719086
74Arachidonic acid metabolism_Homo sapiens_hsa005900.39880715
75Long-term depression_Homo sapiens_hsa047300.39405463
76Collecting duct acid secretion_Homo sapiens_hsa049660.38781549
77Aldosterone synthesis and secretion_Homo sapiens_hsa049250.38083205
78Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.37403271
79Inositol phosphate metabolism_Homo sapiens_hsa005620.36560884
80Arginine and proline metabolism_Homo sapiens_hsa003300.36312025
81cAMP signaling pathway_Homo sapiens_hsa040240.35857612
82Graft-versus-host disease_Homo sapiens_hsa053320.35749980
83Non-small cell lung cancer_Homo sapiens_hsa052230.35111558
84Oxytocin signaling pathway_Homo sapiens_hsa049210.34870356
85Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.33780995
86Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.33559625
87Dorso-ventral axis formation_Homo sapiens_hsa043200.33408375
88Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.32761749
89Protein export_Homo sapiens_hsa030600.30891108
90Glucagon signaling pathway_Homo sapiens_hsa049220.30601933
91Salivary secretion_Homo sapiens_hsa049700.28894329
92Chemical carcinogenesis_Homo sapiens_hsa052040.28842419
93Fatty acid metabolism_Homo sapiens_hsa012120.28604388
94Cocaine addiction_Homo sapiens_hsa050300.28152213
95Central carbon metabolism in cancer_Homo sapiens_hsa052300.27673049
96Glycerophospholipid metabolism_Homo sapiens_hsa005640.27201681
97Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.27155660
98Type II diabetes mellitus_Homo sapiens_hsa049300.26748514
99Purine metabolism_Homo sapiens_hsa002300.25890012
100Fructose and mannose metabolism_Homo sapiens_hsa000510.25804441
101Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.25322852
102Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.25081071
103Renin secretion_Homo sapiens_hsa049240.24910682
104Longevity regulating pathway - mammal_Homo sapiens_hsa042110.24194063
105Nucleotide excision repair_Homo sapiens_hsa034200.23917199
106Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.22676905
107Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.22473566
108Dilated cardiomyopathy_Homo sapiens_hsa054140.20760896
109Amphetamine addiction_Homo sapiens_hsa050310.20518833
110Fatty acid biosynthesis_Homo sapiens_hsa000610.20508589
111Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.20363906
112Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.20304381
113Gastric acid secretion_Homo sapiens_hsa049710.20280527
114Tryptophan metabolism_Homo sapiens_hsa003800.20020016
115AMPK signaling pathway_Homo sapiens_hsa041520.19741303
116Metabolic pathways_Homo sapiens_hsa011000.19681757
117PPAR signaling pathway_Homo sapiens_hsa033200.19612827
118Complement and coagulation cascades_Homo sapiens_hsa046100.18747331
119Biosynthesis of amino acids_Homo sapiens_hsa012300.17703993
120SNARE interactions in vesicular transport_Homo sapiens_hsa041300.17618400
121Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.17505421
122Long-term potentiation_Homo sapiens_hsa047200.16983324
123Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.16549798
124Insulin resistance_Homo sapiens_hsa049310.15723436
125HIF-1 signaling pathway_Homo sapiens_hsa040660.15708607
126Pyruvate metabolism_Homo sapiens_hsa006200.14977877
127Fatty acid degradation_Homo sapiens_hsa000710.14595843
128Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.14446206
129Chemokine signaling pathway_Homo sapiens_hsa040620.13753664
130Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.13720086
131Peroxisome_Homo sapiens_hsa041460.13111863
132Thyroid hormone synthesis_Homo sapiens_hsa049180.12806873
133Alcoholism_Homo sapiens_hsa050340.12615943
134Ras signaling pathway_Homo sapiens_hsa040140.12089473
135Fat digestion and absorption_Homo sapiens_hsa049750.11812827
136Adipocytokine signaling pathway_Homo sapiens_hsa049200.10362944
137Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.09260165
138Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.09199061
139Vitamin digestion and absorption_Homo sapiens_hsa049770.09196341
1402-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.09026457
141Choline metabolism in cancer_Homo sapiens_hsa052310.08876684
142Cardiac muscle contraction_Homo sapiens_hsa042600.07877993
143Calcium signaling pathway_Homo sapiens_hsa040200.07502321
144Endometrial cancer_Homo sapiens_hsa052130.07473798
145Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.07358012
146Steroid hormone biosynthesis_Homo sapiens_hsa001400.07026902
147Glioma_Homo sapiens_hsa052140.06893907
148Ovarian steroidogenesis_Homo sapiens_hsa049130.06851076
149mRNA surveillance pathway_Homo sapiens_hsa030150.06732124
150Starch and sucrose metabolism_Homo sapiens_hsa005000.06653499

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