INCENP

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: In mammalian cells, 2 broad groups of centromere-interacting proteins have been described: constitutively binding centromere proteins and 'passenger,' or transiently interacting, proteins (reviewed by Choo, 1997). The constitutive proteins include CENPA (centromere protein A; MIM 117139), CENPB (MIM 117140), CENPC1 (MIM 117141), and CENPD (MIM 117142). The term 'passenger proteins' encompasses a broad collection of proteins that localize to the centromere during specific stages of the cell cycle (Earnshaw and Mackay, 1994 [PubMed 8088460]). These include CENPE (MIM 117143); MCAK (MIM 604538); KID (MIM 603213); cytoplasmic dynein (e.g., MIM 600112); CliPs (e.g., MIM 179838); and CENPF/mitosin (MIM 600236). The inner centromere proteins (INCENPs) (Earnshaw and Cooke, 1991 [PubMed 1860899]), the initial members of the passenger protein group, display a broad localization along chromosomes in the early stages of mitosis but gradually become concentrated at centromeres as the cell cycle progresses into mid-metaphase. During telophase, the proteins are located within the midbody in the intercellular bridge, where they are discarded after cytokinesis (Cutts et al., 1999 [PubMed 10369859]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein localization to kinetochore (GO:0034501)5.69602490
2DNA unwinding involved in DNA replication (GO:0006268)5.32829443
3mitotic sister chromatid segregation (GO:0000070)5.18998962
4protein localization to chromosome, centromeric region (GO:0071459)5.03155586
5sister chromatid segregation (GO:0000819)4.88594650
6mitotic chromosome condensation (GO:0007076)4.64700054
7DNA strand elongation involved in DNA replication (GO:0006271)4.49591288
8mitotic metaphase plate congression (GO:0007080)4.46878932
9regulation of attachment of spindle microtubules to kinetochore (GO:0051988)4.41441469
10kinetochore organization (GO:0051383)4.36957947
11DNA replication initiation (GO:0006270)4.34928865
12DNA strand elongation (GO:0022616)4.25676711
13mitotic nuclear envelope disassembly (GO:0007077)4.20794639
14nuclear pore organization (GO:0006999)4.15509978
15telomere maintenance via semi-conservative replication (GO:0032201)4.14822736
16nuclear pore complex assembly (GO:0051292)4.08656787
17DNA replication checkpoint (GO:0000076)4.06463130
18positive regulation of chromosome segregation (GO:0051984)4.04255638
19DNA replication-dependent nucleosome assembly (GO:0006335)4.03963285
20DNA replication-dependent nucleosome organization (GO:0034723)4.03963285
21metaphase plate congression (GO:0051310)3.96433628
22spliceosomal tri-snRNP complex assembly (GO:0000244)3.94735877
23membrane disassembly (GO:0030397)3.90051818
24nuclear envelope disassembly (GO:0051081)3.90051818
25regulation of RNA export from nucleus (GO:0046831)3.87009862
26positive regulation of mitotic sister chromatid separation (GO:1901970)3.86239547
27positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.86239547
28positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.86239547
29regulation of spindle organization (GO:0090224)3.83041760
30mitotic recombination (GO:0006312)3.81793137
31kinetochore assembly (GO:0051382)3.78896999
32telomere maintenance via recombination (GO:0000722)3.77969685
33regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.77955638
34DNA duplex unwinding (GO:0032508)3.72655364
35DNA geometric change (GO:0032392)3.71940453
36establishment of chromosome localization (GO:0051303)3.70249457
37attachment of spindle microtubules to kinetochore (GO:0008608)3.70220289
38meiotic chromosome segregation (GO:0045132)3.67809162
39protein localization to chromosome (GO:0034502)3.66717008
40heterochromatin organization (GO:0070828)3.64502897
41mitotic sister chromatid cohesion (GO:0007064)3.63219963
42regulation of sister chromatid cohesion (GO:0007063)3.62486134
43protein complex localization (GO:0031503)3.57821337
44regulation of mammary gland epithelial cell proliferation (GO:0033599)3.56873230
45nucleosome disassembly (GO:0006337)3.52554863
46protein-DNA complex disassembly (GO:0032986)3.52554863
47chromatin remodeling at centromere (GO:0031055)3.49073581
48CENP-A containing nucleosome assembly (GO:0034080)3.47358570
49negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.47333973
50regulation of chromosome segregation (GO:0051983)3.46007291
51DNA replication-independent nucleosome organization (GO:0034724)3.45086894
52DNA replication-independent nucleosome assembly (GO:0006336)3.45086894
53chromatin assembly or disassembly (GO:0006333)3.41020698
54folic acid-containing compound biosynthetic process (GO:0009396)3.38853016
55regulation of histone H3-K9 methylation (GO:0051570)3.37978326
56telomere maintenance via telomere lengthening (GO:0010833)3.35334852
57regulation of mitotic spindle organization (GO:0060236)3.35266375
58formation of translation preinitiation complex (GO:0001731)3.34466616
59establishment of integrated proviral latency (GO:0075713)3.34314406
60regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.33898302
61nucleotide-excision repair, DNA gap filling (GO:0006297)3.33731757
62chromosome condensation (GO:0030261)3.32866212
63regulation of nucleobase-containing compound transport (GO:0032239)3.31995847
64glucocorticoid receptor signaling pathway (GO:0042921)3.29051523
65mRNA stabilization (GO:0048255)3.29021964
66RNA stabilization (GO:0043489)3.29021964
67cellular protein complex localization (GO:0034629)3.28328042
68DNA conformation change (GO:0071103)3.27039563
69IMP biosynthetic process (GO:0006188)3.26762096
70COPI coating of Golgi vesicle (GO:0048205)3.26451404
71Golgi transport vesicle coating (GO:0048200)3.26451404
72* chromosome segregation (GO:0007059)3.25164521
73chromatin assembly (GO:0031497)3.25046422
74DNA synthesis involved in DNA repair (GO:0000731)3.24166840
75pore complex assembly (GO:0046931)3.18471673
76negative regulation of histone methylation (GO:0031061)3.18178181
77negative regulation of RNA splicing (GO:0033119)3.18137261
78positive regulation of DNA-dependent DNA replication (GO:2000105)3.17595619
79negative regulation of chromosome segregation (GO:0051985)3.15661857
80negative regulation of mRNA metabolic process (GO:1903312)3.15516183
81DNA topological change (GO:0006265)3.15128030
82spindle checkpoint (GO:0031577)3.14876475
83regulation of centrosome cycle (GO:0046605)3.14151288
84regulation of mitotic metaphase/anaphase transition (GO:0030071)3.13430877
85pre-miRNA processing (GO:0031054)3.11857509
86peptidyl-arginine omega-N-methylation (GO:0035247)3.10828428
87maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.10594162
88V(D)J recombination (GO:0033151)3.10293286
89protein export from nucleus (GO:0006611)3.10124538
90histone exchange (GO:0043486)3.09739295
91nuclear envelope organization (GO:0006998)3.07945714
92negative regulation of mRNA processing (GO:0050686)3.06929004
93regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.06881241
94regulation of histone H3-K27 methylation (GO:0061085)3.06007469
95dosage compensation (GO:0007549)3.05600335
96regulation of translational termination (GO:0006449)3.05475308
97spindle assembly checkpoint (GO:0071173)3.04320846
98proline biosynthetic process (GO:0006561)3.02430619
99translesion synthesis (GO:0019985)3.00541429
100negative regulation of mitotic sister chromatid separation (GO:2000816)3.00246082
101negative regulation of mitotic sister chromatid segregation (GO:0033048)3.00246082
102negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.00246082
103negative regulation of sister chromatid segregation (GO:0033046)3.00246082
104ATP-dependent chromatin remodeling (GO:0043044)2.99942123
105regulation of sister chromatid segregation (GO:0033045)2.99198638
106regulation of mitotic sister chromatid separation (GO:0010965)2.99198638
107regulation of mitotic sister chromatid segregation (GO:0033047)2.99198638
108nucleobase biosynthetic process (GO:0046112)2.97953277
109DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla2.95945275
110DNA packaging (GO:0006323)2.95642290
111activation of Rac GTPase activity (GO:0032863)2.94874745
112mitotic spindle assembly checkpoint (GO:0007094)2.94775579
113somatic hypermutation of immunoglobulin genes (GO:0016446)2.93467456
114somatic diversification of immune receptors via somatic mutation (GO:0002566)2.93467456
115negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.92157871
116regulation of telomere maintenance via telomerase (GO:0032210)2.91689504
117microtubule depolymerization (GO:0007019)2.89713482
118mitotic spindle checkpoint (GO:0071174)2.89287848
119regulation of translational fidelity (GO:0006450)2.87990214
120base-excision repair (GO:0006284)2.87550500
121protein K6-linked ubiquitination (GO:0085020)2.86993496
122IMP metabolic process (GO:0046040)2.85283968
123maturation of SSU-rRNA (GO:0030490)2.83835892
124regulation of nuclear cell cycle DNA replication (GO:0033262)2.83777307
125spindle organization (GO:0007051)2.82808320
126regulation of NFAT protein import into nucleus (GO:0051532)2.82360175
127double-strand break repair via nonhomologous end joining (GO:0006303)2.82224763
128non-recombinational repair (GO:0000726)2.82224763
129histone phosphorylation (GO:0016572)2.81105487
130mitotic G1 DNA damage checkpoint (GO:0031571)2.80031483
131positive regulation of cell cycle checkpoint (GO:1901978)2.78865777
132DNA ligation (GO:0006266)2.76364285
133establishment of mitotic spindle localization (GO:0040001)2.75115124
134mRNA transport (GO:0051028)2.73537549
135mitotic cytokinesis (GO:0000281)2.71486947
136peptidyl-lysine dimethylation (GO:0018027)2.67909139
137negative regulation of DNA repair (GO:0045738)2.66970354
138G1 DNA damage checkpoint (GO:0044783)2.65615721
139regulation of centriole replication (GO:0046599)2.64359581
140corticosteroid receptor signaling pathway (GO:0031958)2.63507310
141adherens junction assembly (GO:0034333)2.61432616
142peptidyl-arginine methylation (GO:0018216)2.59472823

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* FOXM1_23109430_ChIP-Seq_U2OS_Human6.21419526
2* E2F4_17652178_ChIP-ChIP_JURKAT_Human4.16682637
3* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.78090692
4* MYC_18555785_ChIP-Seq_MESCs_Mouse3.47846431
5EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.33645250
6EGR1_19374776_ChIP-ChIP_THP-1_Human2.76148348
7* MYC_19079543_ChIP-ChIP_MESCs_Mouse2.63281509
8MYC_22102868_ChIP-Seq_BL_Human2.46651181
9MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.39071551
10* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.36827973
11AR_21909140_ChIP-Seq_LNCAP_Human2.28648096
12E2F1_21310950_ChIP-Seq_MCF-7_Human2.26070750
13* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.17103681
14XRN2_22483619_ChIP-Seq_HELA_Human2.02382572
15E2F7_22180533_ChIP-Seq_HELA_Human10.0070881
16NELFA_20434984_ChIP-Seq_ESCs_Mouse1.99400387
17* EST1_17652178_ChIP-ChIP_JURKAT_Human1.89860244
18* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.87953905
19* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.85772263
20* ETS1_20019798_ChIP-Seq_JURKAT_Human1.82069838
21TP63_17297297_ChIP-ChIP_HaCaT_Human1.81872520
22CREB1_15753290_ChIP-ChIP_HEK293T_Human1.78586057
23VDR_21846776_ChIP-Seq_THP-1_Human1.77858190
24ZNF263_19887448_ChIP-Seq_K562_Human1.74819874
25CIITA_25753668_ChIP-Seq_RAJI_Human1.73598817
26HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.71987913
27MYCN_18555785_ChIP-Seq_MESCs_Mouse1.69676355
28TP63_19390658_ChIP-ChIP_HaCaT_Human1.68256057
29* KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.65412779
30NANOG_18555785_ChIP-Seq_MESCs_Mouse1.63066070
31SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.59017561
32* CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.57788197
33VDR_23849224_ChIP-Seq_CD4+_Human1.57057422
34POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.55184834
35FOXP3_21729870_ChIP-Seq_TREG_Human1.52604702
36TTF2_22483619_ChIP-Seq_HELA_Human1.50179946
37JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.48578706
38* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.47810739
39KDM5A_27292631_Chip-Seq_BREAST_Human1.47024158
40E2F1_18555785_ChIP-Seq_MESCs_Mouse1.43513028
41TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.41369484
42GABP_17652178_ChIP-ChIP_JURKAT_Human1.40344184
43GABP_19822575_ChIP-Seq_HepG2_Human1.39962966
44DCP1A_22483619_ChIP-Seq_HELA_Human1.37765192
45NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.37712429
46* ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.34297291
47MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.33327867
48THAP11_20581084_ChIP-Seq_MESCs_Mouse1.32659778
49* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.32160603
50RACK7_27058665_Chip-Seq_MCF-7_Human1.31499565
51* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.30354885
52NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.28691491
53POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.28367754
54* LXR_22292898_ChIP-Seq_THP-1_Human1.27879996
55YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.26565741
56DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.26479387
57PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.26184374
58HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.25450796
59EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.25316676
60KLF4_18555785_ChIP-Seq_MESCs_Mouse1.25180254
61* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.24892581
62STAT3_1855785_ChIP-Seq_MESCs_Mouse1.24761617
63ELF1_17652178_ChIP-ChIP_JURKAT_Human1.18243170
64KDM2B_26808549_Chip-Seq_SUP-B15_Human1.17006897
65* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.16855576
66TFEB_21752829_ChIP-Seq_HELA_Human1.16627990
67P300_27058665_Chip-Seq_ZR-75-30cells_Human1.15692976
68NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.14922847
69CLOCK_20551151_ChIP-Seq_293T_Human1.13998918
70* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.13445860
71* TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.13068257
72SOX2_18555785_ChIP-Seq_MESCs_Mouse1.12830047
73PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.12400172
74* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.12295664
75* KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.11942167
76SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.11802444
77ELK1_19687146_ChIP-ChIP_HELA_Human1.11313023
78ZFP281_18757296_ChIP-ChIP_E14_Mouse1.09135360
79KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.08612028
80KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.08612028
81KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.08612028
82NANOG_21062744_ChIP-ChIP_HESCs_Human1.06246873
83CHD1_26751641_Chip-Seq_LNCaP_Human1.05859039
84ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.05476482
85* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.05326090
86ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.04861606
87KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.04603322
88ATF3_27146783_Chip-Seq_COLON_Human1.04294522
89* SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.03790447
90YY1_21170310_ChIP-Seq_MESCs_Mouse1.03447792
91TCF7_22412390_ChIP-Seq_EML_Mouse1.02479889
92PKCTHETA_26484144_Chip-Seq_BREAST_Human1.02107130
93POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.01875276
94UTX_26944678_Chip-Seq_JUKART_Human1.01582331
95KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.98702389
96* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.97419858
97RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.95623562
98* MAF_26560356_Chip-Seq_TH1_Human0.95143048
99* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.94677353
100FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.93335147
101* SPI1_23547873_ChIP-Seq_NB4_Human0.92453252
102ERG_20887958_ChIP-Seq_HPC-7_Mouse0.92418776
103WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.92069785
104KDM2B_26808549_Chip-Seq_JURKAT_Human0.91294882
105TCF3_18692474_ChIP-Seq_MEFs_Mouse0.91126001
106ESR1_15608294_ChIP-ChIP_MCF-7_Human0.91110805
107DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.90499748
108KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.90471002
109TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.89621899
110KDM2B_26808549_Chip-Seq_K562_Human0.88893922
111PADI4_21655091_ChIP-ChIP_MCF-7_Human0.88187643
112SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.87508790
113KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.87350927
114UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.86371106
115SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.85596703
116ZFP281_27345836_Chip-Seq_ESCs_Mouse0.85568734
117* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.85267166
118ELK3_25401928_ChIP-Seq_HUVEC_Human0.85144245
119MYB_26560356_Chip-Seq_TH1_Human0.84648955
120CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.84455033
121STAT6_21828071_ChIP-Seq_BEAS2B_Human0.84080448
122FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.82785484
123SCL_19346495_ChIP-Seq_HPC-7_Human0.82308390
124GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.81441947
125SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.81305004
126HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.81212489
127KDM2B_26808549_Chip-Seq_DND41_Human0.80933470
128NCOR1_26117541_ChIP-Seq_K562_Human0.80753286
129MYB_26560356_Chip-Seq_TH2_Human0.78168675
130BRD4_27068464_Chip-Seq_AML-cells_Mouse0.77759048

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.64819998
2MP0003111_abnormal_nucleus_morphology4.64658849
3MP0010094_abnormal_chromosome_stability4.45882274
4MP0008057_abnormal_DNA_replication4.07763104
5MP0003077_abnormal_cell_cycle3.87531314
6* MP0004957_abnormal_blastocyst_morpholog3.70781454
7MP0008058_abnormal_DNA_repair2.55598790
8MP0010352_gastrointestinal_tract_polyps2.53625194
9MP0010307_abnormal_tumor_latency2.48538914
10MP0001730_embryonic_growth_arrest2.43023188
11MP0008007_abnormal_cellular_replicative2.41698359
12MP0002396_abnormal_hematopoietic_system2.40672861
13MP0000350_abnormal_cell_proliferation2.36528353
14MP0010234_abnormal_vibrissa_follicle2.34797475
15MP0008932_abnormal_embryonic_tissue2.29010299
16MP0005076_abnormal_cell_differentiation2.12223731
17MP0004185_abnormal_adipocyte_glucose2.09648292
18MP0008877_abnormal_DNA_methylation2.00692116
19MP0003123_paternal_imprinting1.95932104
20MP0005380_embryogenesis_phenotype1.93366107
21MP0001672_abnormal_embryogenesis/_devel1.93366107
22MP0004233_abnormal_muscle_weight1.90550083
23MP0005451_abnormal_body_composition1.87735934
24MP0001697_abnormal_embryo_size1.85738261
25MP0009278_abnormal_bone_marrow1.81566874
26MP0000490_abnormal_crypts_of1.75779908
27MP0003984_embryonic_growth_retardation1.75268181
28MP0002088_abnormal_embryonic_growth/wei1.71703842
29MP0004808_abnormal_hematopoietic_stem1.70877769
30* MP0002085_abnormal_embryonic_tissue1.70164048
31MP0002084_abnormal_developmental_patter1.66603919
32MP0004197_abnormal_fetal_growth/weight/1.65935301
33MP0003705_abnormal_hypodermis_morpholog1.64498878
34* MP0002080_prenatal_lethality1.63786707
35* MP0002086_abnormal_extraembryonic_tissu1.62619681
36MP0005623_abnormal_meninges_morphology1.58812192
37MP0005397_hematopoietic_system_phenotyp1.56621883
38MP0001545_abnormal_hematopoietic_system1.56621883
39MP0002009_preneoplasia1.52165868
40MP0002019_abnormal_tumor_incidence1.52040687
41MP0003786_premature_aging1.49111135
42MP0003121_genomic_imprinting1.48538827
43MP0000313_abnormal_cell_death1.48147298
44MP0010030_abnormal_orbit_morphology1.44799597
45MP0005257_abnormal_intraocular_pressure1.38392766
46MP0003567_abnormal_fetal_cardiomyocyte1.35202160
47MP0005409_darkened_coat_color1.33082892
48MP0003890_abnormal_embryonic-extraembry1.32508189
49MP0000703_abnormal_thymus_morphology1.32475246
50MP0001348_abnormal_lacrimal_gland1.27374609
51MP0001346_abnormal_lacrimal_gland1.26648978
52MP0002398_abnormal_bone_marrow1.26124339
53MP0009333_abnormal_splenocyte_physiolog1.24070487
54MP0002722_abnormal_immune_system1.15533996
55MP0002089_abnormal_postnatal_growth/wei1.15021614
56MP0002796_impaired_skin_barrier1.11225572
57MP0001293_anophthalmia1.09683370
58MP0003763_abnormal_thymus_physiology1.07988830
59MP0000689_abnormal_spleen_morphology1.07067854
60MP0001849_ear_inflammation1.06976197
61MP0003453_abnormal_keratinocyte_physiol1.06779506
62MP0003566_abnormal_cell_adhesion1.05046156
63MP0000003_abnormal_adipose_tissue1.04004252
64MP0009053_abnormal_anal_canal1.03077550
65MP0001661_extended_life_span1.02000410
66MP0001915_intracranial_hemorrhage1.01333974
67MP0002210_abnormal_sex_determination1.01091598
68MP0005171_absent_coat_pigmentation1.00731114
69MP0002060_abnormal_skin_morphology0.99517437
70MP0003119_abnormal_digestive_system0.97540482
71MP0000566_synostosis0.97432219
72MP0003091_abnormal_cell_migration0.97316349
73MP0009672_abnormal_birth_weight0.96495798
74MP0008438_abnormal_cutaneous_collagen0.94979884
75MP0000858_altered_metastatic_potential0.93604215
76MP0005023_abnormal_wound_healing0.92972120
77MP0003385_abnormal_body_wall0.92970453
78MP0002429_abnormal_blood_cell0.91402048
79MP0001145_abnormal_male_reproductive0.90985234
80MP0009703_decreased_birth_body0.88754358
81MP0000678_abnormal_parathyroid_gland0.88711042
82MP0000537_abnormal_urethra_morphology0.88578278
83MP0002249_abnormal_larynx_morphology0.87338167
84MP0004858_abnormal_nervous_system0.86300211
85MP0005666_abnormal_adipose_tissue0.85879351
86MP0002653_abnormal_ependyma_morphology0.84669597
87MP0005621_abnormal_cell_physiology0.84307395
88MP0000733_abnormal_muscle_development0.83482747
89MP0002111_abnormal_tail_morphology0.82908498
90MP0000428_abnormal_craniofacial_morphol0.82585997
91MP0004264_abnormal_extraembryonic_tissu0.81466498
92MP0009697_abnormal_copulation0.80121959
93MP0003303_peritoneal_inflammation0.79494111
94MP0004272_abnormal_basement_membrane0.79319245
95MP0001929_abnormal_gametogenesis0.79232893
96MP0000716_abnormal_immune_system0.79083368
97MP0005384_cellular_phenotype0.79049971
98MP0002092_abnormal_eye_morphology0.79018764
99MP0003861_abnormal_nervous_system0.77598553
100MP0003448_altered_tumor_morphology0.77415955
101MP0002925_abnormal_cardiovascular_devel0.77098696
102MP0003937_abnormal_limbs/digits/tail_de0.76479218
103MP0003787_abnormal_imprinting0.75679433
104MP0002697_abnormal_eye_size0.75570420
105MP0008770_decreased_survivor_rate0.75125324
106MP0000579_abnormal_nail_morphology0.73442680
107MP0010630_abnormal_cardiac_muscle0.73235045
108MP0003942_abnormal_urinary_system0.72567179
109MP0000685_abnormal_immune_system0.72343229
110MP0005375_adipose_tissue_phenotype0.71905870
111MP0001216_abnormal_epidermal_layer0.71870809
112MP0000653_abnormal_sex_gland0.71764268
113MP0003718_maternal_effect0.71369075
114MP0000477_abnormal_intestine_morphology0.71023885
115MP0002405_respiratory_system_inflammati0.70767407
116MP0000432_abnormal_head_morphology0.69780974
117MP0000377_abnormal_hair_follicle0.69002942
118MP0001800_abnormal_humoral_immune0.68956544
119MP0003115_abnormal_respiratory_system0.68197394
120MP0003315_abnormal_perineum_morphology0.67918573
121MP0008260_abnormal_autophagy0.67634548
122MP0002075_abnormal_coat/hair_pigmentati0.67324755
123MP0000762_abnormal_tongue_morphology0.66259123
124MP0003935_abnormal_craniofacial_develop0.65566980
125MP0009931_abnormal_skin_appearance0.65524476
126MP0003221_abnormal_cardiomyocyte_apopto0.65464856
127MP0002098_abnormal_vibrissa_morphology0.64463763
128MP0003656_abnormal_erythrocyte_physiolo0.64393565
129MP0002166_altered_tumor_susceptibility0.64331339
130MP0006054_spinal_hemorrhage0.63037570
131MP0005501_abnormal_skin_physiology0.61315607
132MP0001119_abnormal_female_reproductive0.60927577
133MP0001286_abnormal_eye_development0.60091267
134MP0002932_abnormal_joint_morphology0.59070175
135MP0000266_abnormal_heart_morphology0.58868675
136MP0002420_abnormal_adaptive_immunity0.57977774
137MP0002452_abnormal_antigen_presenting0.57505825
138MP0000358_abnormal_cell_content/0.57112854
139MP0001819_abnormal_immune_cell0.57093573
140MP0002877_abnormal_melanocyte_morpholog0.56567157
141MP0005174_abnormal_tail_pigmentation0.56457371

Predicted human phenotypes

RankGene SetZ-score
1Chromsome breakage (HP:0040012)4.26077685
2Chromosomal breakage induced by crosslinking agents (HP:0003221)4.14326288
3Ependymoma (HP:0002888)3.39489270
4Reticulocytopenia (HP:0001896)3.31664190
5Birth length less than 3rd percentile (HP:0003561)3.21826822
6Selective tooth agenesis (HP:0001592)3.19953401
7Meckel diverticulum (HP:0002245)3.12269293
8Patellar aplasia (HP:0006443)3.11931993
9Abnormality of chromosome stability (HP:0003220)3.11469256
10Abnormality of the ileum (HP:0001549)3.03588172
11Increased nuchal translucency (HP:0010880)2.99330485
12Insomnia (HP:0100785)2.94098999
13Volvulus (HP:0002580)2.92635186
14Medulloblastoma (HP:0002885)2.91677035
15Aplasia/Hypoplasia of the patella (HP:0006498)2.90115108
16Aplasia/Hypoplasia of the uvula (HP:0010293)2.88243016
17Abnormality of the preputium (HP:0100587)2.81246801
18Small intestinal stenosis (HP:0012848)2.74867897
19Duodenal stenosis (HP:0100867)2.74867897
20Myelodysplasia (HP:0002863)2.74176339
21Ectopic kidney (HP:0000086)2.68017551
22Proximal placement of thumb (HP:0009623)2.63607038
23Impulsivity (HP:0100710)2.63243619
24Colon cancer (HP:0003003)2.60017766
25Rhabdomyosarcoma (HP:0002859)2.59212369
26Breast hypoplasia (HP:0003187)2.59029324
27Deviation of the thumb (HP:0009603)2.57861587
28Absent thumb (HP:0009777)2.57133668
29Abnormal number of incisors (HP:0011064)2.54244183
30Absent radius (HP:0003974)2.53401034
31Basal cell carcinoma (HP:0002671)2.50213987
32Astrocytoma (HP:0009592)2.46179906
33Abnormality of the astrocytes (HP:0100707)2.46179906
34Facial hemangioma (HP:0000329)2.43224873
35High pitched voice (HP:0001620)2.43027345
36Asymmetry of the thorax (HP:0001555)2.41050680
37Agnosia (HP:0010524)2.40708752
38High anterior hairline (HP:0009890)2.40469712
39Short 4th metacarpal (HP:0010044)2.37728814
40Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.37728814
41Broad face (HP:0000283)2.36693594
42Prominent nose (HP:0000448)2.35978355
43Dysmetric saccades (HP:0000641)2.35173774
44Cafe-au-lait spot (HP:0000957)2.34575126
45Aplasia involving forearm bones (HP:0009822)2.34529793
46Absent forearm bone (HP:0003953)2.34529793
47Abnormality of the labia minora (HP:0012880)2.33732657
48Ankyloglossia (HP:0010296)2.32683206
49Abnormality of cells of the erythroid lineage (HP:0012130)2.32136205
50Urethral obstruction (HP:0000796)2.27550760
51Long palpebral fissure (HP:0000637)2.27238497
52Abnormality of the carotid arteries (HP:0005344)2.27039838
53Carpal bone hypoplasia (HP:0001498)2.24755600
54Abnormality of the duodenum (HP:0002246)2.23596528
55Abnormal number of erythroid precursors (HP:0012131)2.22157248
56Progressive muscle weakness (HP:0003323)2.22008885
57Disproportionate tall stature (HP:0001519)2.21710482
58Atresia of the external auditory canal (HP:0000413)2.19360152
59Tracheoesophageal fistula (HP:0002575)2.19058194
60Neoplasm of striated muscle (HP:0009728)2.18868003
61Abnormal lung lobation (HP:0002101)2.18680950
62Overriding aorta (HP:0002623)2.18208628
63Degeneration of anterior horn cells (HP:0002398)2.18108073
64Abnormality of the anterior horn cell (HP:0006802)2.18108073
65Squamous cell carcinoma (HP:0002860)2.17496670
66Abnormality of the fingertips (HP:0001211)2.17464234
67Elfin facies (HP:0004428)2.17230377
68Abnormality of the distal phalanx of the thumb (HP:0009617)2.15929958
69Sloping forehead (HP:0000340)2.14411853
70Rib fusion (HP:0000902)2.13199672
71Distal lower limb amyotrophy (HP:0008944)2.12339087
72Bone marrow hypocellularity (HP:0005528)2.11373286
73Heterotopia (HP:0002282)2.11180007
74Broad distal phalanx of finger (HP:0009836)2.09642870
75Abnormality of oral frenula (HP:0000190)2.08751497
76Cortical dysplasia (HP:0002539)2.07030026
77Short thumb (HP:0009778)2.06985675
78Abnormality of reticulocytes (HP:0004312)2.05878725
79Termporal pattern (HP:0011008)2.05123846
80Insidious onset (HP:0003587)2.05123846
81Deep palmar crease (HP:0006191)2.04582073
82Overlapping toe (HP:0001845)2.04250536
83Abnormality of chromosome segregation (HP:0002916)2.01767742
84Nephroblastoma (Wilms tumor) (HP:0002667)2.01755588
85Neoplasm of the oral cavity (HP:0100649)2.01676647
86Long eyelashes (HP:0000527)2.01222014
87Hyperacusis (HP:0010780)2.01199045
88Glioma (HP:0009733)2.00769230
89Deep philtrum (HP:0002002)2.00534770
90Premature rupture of membranes (HP:0001788)1.99721523
91Pointed chin (HP:0000307)1.98712297
92Broad palm (HP:0001169)1.98425107
93Neoplasm of the pancreas (HP:0002894)1.97277868
94Abnormal gallbladder physiology (HP:0012438)1.97167617
95Cholecystitis (HP:0001082)1.97167617
96Pallor (HP:0000980)1.95686469
97Achilles tendon contracture (HP:0001771)1.95538472
98Duplicated collecting system (HP:0000081)1.94381966
99Missing ribs (HP:0000921)1.92459628
100Oral leukoplakia (HP:0002745)1.91833946
101Hypopigmentation of the fundus (HP:0007894)1.91679832
102Clubbing of toes (HP:0100760)1.90591814
103Ulnar bowing (HP:0003031)1.89761304
104Progressive external ophthalmoplegia (HP:0000590)1.89047599
105Patellar dislocation (HP:0002999)1.88861397
106Aplasia/hypoplasia of the humerus (HP:0006507)1.86101805
107Embryonal renal neoplasm (HP:0011794)1.84580367
10811 pairs of ribs (HP:0000878)1.83813368
109Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.83231421
110Trigonocephaly (HP:0000243)1.83023373
111Shallow orbits (HP:0000586)1.82993478
112Flat acetabular roof (HP:0003180)1.81542597
113Aplasia/Hypoplasia of the sternum (HP:0006714)1.81251392
114Renal duplication (HP:0000075)1.80939548
115Abnormality of the phalanges of the hallux (HP:0010057)1.80020240
116Multiple enchondromatosis (HP:0005701)1.80004451
117Trismus (HP:0000211)1.79928450
118Malignant gastrointestinal tract tumors (HP:0006749)1.79854462
119Gastrointestinal carcinoma (HP:0002672)1.79854462
120Skin tags (HP:0010609)1.79442071
121Orthostatic hypotension (HP:0001278)1.79355764
122Supernumerary spleens (HP:0009799)1.78641675
123Abdominal situs inversus (HP:0003363)1.78230504
124Abnormality of abdominal situs (HP:0011620)1.78230504
125Triphalangeal thumb (HP:0001199)1.78050478
126Flared metaphyses (HP:0003015)1.77943734
127Sparse lateral eyebrow (HP:0005338)1.77105099
128Duplication of thumb phalanx (HP:0009942)1.76921490
129Dislocated radial head (HP:0003083)1.75610248
130Reticulocytosis (HP:0001923)1.75608785
131Abnormality of the calcaneus (HP:0008364)1.74654452
132Obsessive-compulsive behavior (HP:0000722)1.74329376
133Pseudobulbar signs (HP:0002200)1.74137759
134Aplastic anemia (HP:0001915)1.73936473
135Preauricular skin tag (HP:0000384)1.73908521
136Leiomyosarcoma (HP:0100243)1.73855430
137Uterine leiomyosarcoma (HP:0002891)1.73855430
138Increased connective tissue (HP:0009025)1.73641356
139Renovascular hypertension (HP:0100817)1.73398404
140Abnormality of the salivary glands (HP:0010286)1.73322307
141Vertebral arch anomaly (HP:0008438)1.73311305
142Relative macrocephaly (HP:0004482)1.73017910
143Acute lymphatic leukemia (HP:0006721)1.72287699
144Premature graying of hair (HP:0002216)1.71796888
145Horseshoe kidney (HP:0000085)1.71327115
146Rough bone trabeculation (HP:0100670)1.70902850
147Abnormality of the heme biosynthetic pathway (HP:0010472)1.70433893
148Lower limb amyotrophy (HP:0007210)1.70133497
149Septate vagina (HP:0001153)1.69846858
150Microvesicular hepatic steatosis (HP:0001414)1.69493814
151Poikiloderma (HP:0001029)1.68675839
152Hypoplasia of the capital femoral epiphysis (HP:0003090)1.67900572
153Skull defect (HP:0001362)1.67325794
154Back pain (HP:0003418)1.67068067
155Natal tooth (HP:0000695)1.67037719
156Short humerus (HP:0005792)1.67004277
157Abnormality of DNA repair (HP:0003254)1.66094482
158Sandal gap (HP:0001852)1.64361649
159Abnormality of the Achilles tendon (HP:0005109)1.63858971
160Advanced eruption of teeth (HP:0006288)1.63493545
161Arnold-Chiari malformation (HP:0002308)1.61484747
162Thin ribs (HP:0000883)1.60065859
163Syringomyelia (HP:0003396)1.59586525
164Spinal cord lesions (HP:0100561)1.59586525
165Centrally nucleated skeletal muscle fibers (HP:0003687)1.58623896
166Abnormality of the radial head (HP:0003995)1.58375104
167Glossoptosis (HP:0000162)1.55375669

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC74.86270256
2SMG14.03063794
3BUB13.85790163
4CDK123.84802803
5NEK23.55967670
6WEE13.36395831
7MAP3K102.68125176
8EEF2K2.64928159
9TTK2.63203356
10PRPF4B2.21656076
11STK102.05972499
12PLK12.01433834
13CDK71.99751880
14NEK11.92497073
15IRAK31.88424878
16CDK41.82826180
17ATR1.69402823
18RPS6KB21.67547284
19* AURKB1.67480457
20PKN21.65439668
21BRSK21.64390559
22SIK11.62280518
23CHEK21.60272196
24STK41.55442643
25SRPK11.55222919
26TESK21.54932427
27MAP3K81.54796861
28EIF2AK11.54654689
29CHEK11.45540059
30RPS6KA41.44714810
31MST1R1.40186262
32TLK11.37749626
33BRD41.35531504
34PASK1.33311389
35PLK41.29473227
36MKNK11.29337821
37MAP4K11.28681431
38CDK61.26301784
39BRSK11.23669170
40TRIB31.23414226
41AURKA1.22214971
42DYRK31.21900042
43TSSK61.21259718
44FGFR41.17714414
45PLK31.14074067
46PAK41.13762517
47PBK1.11585266
48SCYL21.10496222
49ALK1.10268352
50MKNK21.08819593
51ACVR1B1.06816364
52PIM11.06270717
53GRK61.02496876
54CDK21.02472900
55ATM1.01831793
56TAF10.99783690
57STK30.99353520
58ICK0.98116906
59CAMK1D0.91260976
60NME20.90916473
61VRK20.89714891
62BRAF0.89545849
63EPHA20.88857997
64MTOR0.84425161
65BMX0.83028556
66MELK0.81646058
67LRRK20.78797851
68CLK10.78125229
69KSR20.77498104
70MAP3K90.77075485
71VRK10.76481906
72* CDK10.75163039
73CAMK1G0.74263768
74ERN10.73276628
75CCNB10.70620680
76TGFBR10.67449222
77MET0.67152480
78PAK10.66207815
79MAP3K130.65216482
80PTK20.64748330
81LATS20.64518328
82AKT20.60009833
83TAOK20.59431172
84LATS10.57904708
85RIPK10.57803018
86FLT30.57119635
87TTN0.56121884
88MAP3K110.56109684
89PRKD30.55652877
90BTK0.54740987
91CDK11A0.52763689
92CDK150.51278851
93CSNK2A20.50772681
94CDK80.49806946
95CDK180.47071620
96ARAF0.47003194
97MAPK110.45749472
98CSNK2A10.45496547
99CDK90.45076386
100MAP2K20.44281692
101PAK20.43937336
102MAP2K30.42360263
103MAPK140.41943295
104PTK60.40936644
105PRKDC0.40748732
106CSF1R0.40692280
107RAF10.40454450
108IRAK20.38582559
109MARK30.38058129
110EIF2AK20.36396140
111BLK0.36386679
112TESK10.36130064
113EIF2AK30.35849046
114SIK20.35436674
115TYRO30.35392814
116AKT10.35383230
117NTRK10.35195843
118CSNK1E0.35169312
119ERBB40.34972883
120CDK140.34581795
121CSNK1D0.34492556
122GSK3B0.34160659
123MAPKAPK20.34107367
124RPS6KA10.33036738
125PRKCI0.32917374
126ZAP700.32291079
127MAPK10.31462796
128RPS6KC10.31255776
129RPS6KL10.31255776
130TAOK10.29633306
131CHUK0.29136105
132DYRK1B0.29090622
133PDGFRA0.28579414
134RPS6KA50.28403524

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.94161090
2Mismatch repair_Homo sapiens_hsa034304.17728900
3Spliceosome_Homo sapiens_hsa030403.24226092
4Base excision repair_Homo sapiens_hsa034103.23750250
5Cell cycle_Homo sapiens_hsa041103.17750304
6Homologous recombination_Homo sapiens_hsa034403.05476265
7RNA transport_Homo sapiens_hsa030132.97386117
8Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.94218791
9Nucleotide excision repair_Homo sapiens_hsa034202.55876386
10One carbon pool by folate_Homo sapiens_hsa006702.47633830
11Fanconi anemia pathway_Homo sapiens_hsa034602.44616168
12Ribosome_Homo sapiens_hsa030102.20576387
13mRNA surveillance pathway_Homo sapiens_hsa030152.12423034
14Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.05914898
15Non-homologous end-joining_Homo sapiens_hsa034502.01823954
16p53 signaling pathway_Homo sapiens_hsa041151.81914400
17RNA polymerase_Homo sapiens_hsa030201.79128281
18RNA degradation_Homo sapiens_hsa030181.71945532
19Pyrimidine metabolism_Homo sapiens_hsa002401.68326770
20Basal transcription factors_Homo sapiens_hsa030221.43812857
21Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.36924422
22Systemic lupus erythematosus_Homo sapiens_hsa053221.36089530
23Viral carcinogenesis_Homo sapiens_hsa052031.33706368
24Proteasome_Homo sapiens_hsa030501.28315536
25Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.24721335
26MicroRNAs in cancer_Homo sapiens_hsa052061.22546446
27Oocyte meiosis_Homo sapiens_hsa041141.17852446
28Herpes simplex infection_Homo sapiens_hsa051681.17619615
29Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.15487312
30Epstein-Barr virus infection_Homo sapiens_hsa051691.15403218
31HTLV-I infection_Homo sapiens_hsa051661.10550589
32Small cell lung cancer_Homo sapiens_hsa052221.10283928
33Chronic myeloid leukemia_Homo sapiens_hsa052201.05835922
34Carbon metabolism_Homo sapiens_hsa012001.04037860
35Antigen processing and presentation_Homo sapiens_hsa046121.00935420
36Fructose and mannose metabolism_Homo sapiens_hsa000510.98086482
37Transcriptional misregulation in cancer_Homo sapiens_hsa052020.95252928
38Primary immunodeficiency_Homo sapiens_hsa053400.94290187
39Renal cell carcinoma_Homo sapiens_hsa052110.94119374
402-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.89484176
41ErbB signaling pathway_Homo sapiens_hsa040120.88644385
42Thyroid cancer_Homo sapiens_hsa052160.87396371
43Notch signaling pathway_Homo sapiens_hsa043300.85509066
44Vitamin B6 metabolism_Homo sapiens_hsa007500.83454548
45Colorectal cancer_Homo sapiens_hsa052100.82121942
46Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.80727488
47Apoptosis_Homo sapiens_hsa042100.77801363
48Insulin signaling pathway_Homo sapiens_hsa049100.76459554
49Bladder cancer_Homo sapiens_hsa052190.76303633
50Non-small cell lung cancer_Homo sapiens_hsa052230.75145789
51Hepatitis B_Homo sapiens_hsa051610.74451078
52Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.74331410
53N-Glycan biosynthesis_Homo sapiens_hsa005100.73429696
54Basal cell carcinoma_Homo sapiens_hsa052170.72799684
55Longevity regulating pathway - mammal_Homo sapiens_hsa042110.72578541
56Lysine degradation_Homo sapiens_hsa003100.71820249
57Hippo signaling pathway_Homo sapiens_hsa043900.69191610
58Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.68845956
59AMPK signaling pathway_Homo sapiens_hsa041520.68631138
60Purine metabolism_Homo sapiens_hsa002300.67858895
61Prion diseases_Homo sapiens_hsa050200.67130258
62mTOR signaling pathway_Homo sapiens_hsa041500.66916805
63Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.65913600
64Adherens junction_Homo sapiens_hsa045200.65605826
65Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.65363535
66Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.65038322
67Acute myeloid leukemia_Homo sapiens_hsa052210.64926566
68Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.64894552
69Measles_Homo sapiens_hsa051620.64788339
70Pancreatic cancer_Homo sapiens_hsa052120.64582051
71Focal adhesion_Homo sapiens_hsa045100.63615367
72Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.63410639
73Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.63276987
74B cell receptor signaling pathway_Homo sapiens_hsa046620.62479032
75Shigellosis_Homo sapiens_hsa051310.61635530
76Inositol phosphate metabolism_Homo sapiens_hsa005620.61393756
77Galactose metabolism_Homo sapiens_hsa000520.61323742
78Legionellosis_Homo sapiens_hsa051340.60412171
79Pentose phosphate pathway_Homo sapiens_hsa000300.60364889
80NF-kappa B signaling pathway_Homo sapiens_hsa040640.60149045
81Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.59913309
82TGF-beta signaling pathway_Homo sapiens_hsa043500.56894023
83Biosynthesis of amino acids_Homo sapiens_hsa012300.56826273
84Viral myocarditis_Homo sapiens_hsa054160.56515572
85Central carbon metabolism in cancer_Homo sapiens_hsa052300.55601885
86Prostate cancer_Homo sapiens_hsa052150.54436374
87Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.54325329
88Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.54311471
89Alcoholism_Homo sapiens_hsa050340.53296578
90Selenocompound metabolism_Homo sapiens_hsa004500.52749107
91Pathways in cancer_Homo sapiens_hsa052000.52371938
92Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.50617259
93Estrogen signaling pathway_Homo sapiens_hsa049150.48341123
94Proteoglycans in cancer_Homo sapiens_hsa052050.48129649
95Influenza A_Homo sapiens_hsa051640.48079051
96Melanogenesis_Homo sapiens_hsa049160.47937982
97Phosphatidylinositol signaling system_Homo sapiens_hsa040700.47482483
98HIF-1 signaling pathway_Homo sapiens_hsa040660.46762055
99Endometrial cancer_Homo sapiens_hsa052130.43943044
100Leukocyte transendothelial migration_Homo sapiens_hsa046700.43440947
101Cyanoamino acid metabolism_Homo sapiens_hsa004600.42960847
102Leishmaniasis_Homo sapiens_hsa051400.42347393
103Hedgehog signaling pathway_Homo sapiens_hsa043400.42203413
104Hematopoietic cell lineage_Homo sapiens_hsa046400.41771496
105Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.40783997
106Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.39845157
107Thyroid hormone signaling pathway_Homo sapiens_hsa049190.39748734
108Prolactin signaling pathway_Homo sapiens_hsa049170.39090313
109Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.37562391
110Regulation of actin cytoskeleton_Homo sapiens_hsa048100.35357597
111Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.34964730
112Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.34926224
113Melanoma_Homo sapiens_hsa052180.33518919
114T cell receptor signaling pathway_Homo sapiens_hsa046600.32836566
115FoxO signaling pathway_Homo sapiens_hsa040680.32780494
116Intestinal immune network for IgA production_Homo sapiens_hsa046720.31868819
117Neurotrophin signaling pathway_Homo sapiens_hsa047220.31574310
118NOD-like receptor signaling pathway_Homo sapiens_hsa046210.31097551
119Sulfur relay system_Homo sapiens_hsa041220.31086605
120Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.30774518
121Wnt signaling pathway_Homo sapiens_hsa043100.30609719
122VEGF signaling pathway_Homo sapiens_hsa043700.29071123
123AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.28847049
124Jak-STAT signaling pathway_Homo sapiens_hsa046300.27555503
125Cysteine and methionine metabolism_Homo sapiens_hsa002700.27536294
126Toxoplasmosis_Homo sapiens_hsa051450.27444912
127Glioma_Homo sapiens_hsa052140.27375084

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