INF2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene represents a member of the formin family of proteins. It is considered a diaphanous formin due to the presence of a diaphanous inhibitory domain located at the N-terminus of the encoded protein. Studies of a similar mouse protein indicate that the protein encoded by this locus may function in polymerization and depolymerization of actin filaments. Mutations at this locus have been associated with focal segmental glomerulosclerosis 5. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of synapse structural plasticity (GO:0051823)4.57522989
2adenosine receptor signaling pathway (GO:0001973)4.50702929
3synaptic vesicle maturation (GO:0016188)4.37380761
4positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.21735999
5synaptic transmission, dopaminergic (GO:0001963)4.17256535
6locomotory exploration behavior (GO:0035641)4.15444296
7hemidesmosome assembly (GO:0031581)4.14837723
8prepulse inhibition (GO:0060134)4.13028162
9desmosome organization (GO:0002934)3.86258590
10cell-substrate junction assembly (GO:0007044)3.82405791
11regulation of long-term neuronal synaptic plasticity (GO:0048169)3.71317805
12regulation of short-term neuronal synaptic plasticity (GO:0048172)3.68633554
13central nervous system myelination (GO:0022010)3.68038833
14axon ensheathment in central nervous system (GO:0032291)3.68038833
15activation of Rac GTPase activity (GO:0032863)3.68036230
16regulation of neuronal synaptic plasticity (GO:0048168)3.67918463
17barbed-end actin filament capping (GO:0051016)3.65646736
18neuromuscular process controlling balance (GO:0050885)3.63287828
19adherens junction assembly (GO:0034333)3.54342270
20regulation of dendritic spine morphogenesis (GO:0061001)3.53687510
21regulation of early endosome to late endosome transport (GO:2000641)3.52800460
22membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.51847132
23mannose metabolic process (GO:0006013)3.50118733
24semaphorin-plexin signaling pathway (GO:0071526)3.46813146
25focal adhesion assembly (GO:0048041)3.46585672
26cell-substrate adherens junction assembly (GO:0007045)3.46585672
27regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.41623254
28auditory behavior (GO:0031223)3.40398634
29positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.38692280
30epithelial cell-cell adhesion (GO:0090136)3.36001348
31positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.35896196
32positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.35282119
33substrate-independent telencephalic tangential migration (GO:0021826)3.34830654
34substrate-independent telencephalic tangential interneuron migration (GO:0021843)3.34830654
35glycine transport (GO:0015816)3.33040095
36positive regulation of Cdc42 GTPase activity (GO:0043089)3.32479369
37cytoskeletal anchoring at plasma membrane (GO:0007016)3.32398748
38vocalization behavior (GO:0071625)3.30459724
39regulation of glutamate receptor signaling pathway (GO:1900449)3.25754176
40positive regulation of receptor recycling (GO:0001921)3.23825220
41dendritic spine morphogenesis (GO:0060997)3.21584991
42stress fiber assembly (GO:0043149)3.19837781
43negative regulation of fatty acid transport (GO:2000192)3.17967464
44response to amphetamine (GO:0001975)3.17694473
45neurotransmitter-gated ion channel clustering (GO:0072578)3.17426755
46basement membrane organization (GO:0071711)3.17075186
47neuronal action potential propagation (GO:0019227)3.16936652
48Golgi transport vesicle coating (GO:0048200)3.16137679
49COPI coating of Golgi vesicle (GO:0048205)3.16137679
50behavioral response to cocaine (GO:0048148)3.16109951
51protein retention in ER lumen (GO:0006621)3.13345264
52positive regulation of membrane protein ectodomain proteolysis (GO:0051044)3.07299534
53negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.06891576
54regulation of extracellular matrix disassembly (GO:0010715)3.05608553
55neuronal ion channel clustering (GO:0045161)3.05596297
56striatum development (GO:0021756)3.05129247
57synaptic vesicle docking involved in exocytosis (GO:0016081)3.02590384
58gamma-aminobutyric acid transport (GO:0015812)3.02492496
59regulation of female receptivity (GO:0045924)3.01227481
60ionotropic glutamate receptor signaling pathway (GO:0035235)3.00904875
61maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.99836733
62regulation of glutamate secretion (GO:0014048)2.99507993
63skin morphogenesis (GO:0043589)2.99226056
64regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.99027827
65apoptotic process involved in morphogenesis (GO:0060561)2.97955212
66peptidyl-tyrosine autophosphorylation (GO:0038083)2.97830973
67dopamine receptor signaling pathway (GO:0007212)2.97079543
68regulation of cholesterol homeostasis (GO:2000188)2.96392766
69adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.96322427
70regulation of glucose import in response to insulin stimulus (GO:2001273)2.95746379
71cAMP catabolic process (GO:0006198)2.95204974
72regulation of excitatory postsynaptic membrane potential (GO:0060079)2.94568178
73synaptic vesicle exocytosis (GO:0016079)2.93063743
74endothelial cell chemotaxis (GO:0035767)2.91895092
75positive regulation of extracellular matrix organization (GO:1903055)2.90742779
76negative regulation of cytosolic calcium ion concentration (GO:0051481)2.89946764
77atrioventricular valve morphogenesis (GO:0003181)2.88683469
78negative regulation of erythrocyte differentiation (GO:0045647)2.88234081
79protein localization to endosome (GO:0036010)2.88022760
80G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.86996467
81regulation of synaptic plasticity (GO:0048167)2.85998853
82positive regulation of blood vessel endothelial cell migration (GO:0043536)2.85550907
83regulation of ARF GTPase activity (GO:0032312)2.85499139
84layer formation in cerebral cortex (GO:0021819)2.84240951
85low-density lipoprotein particle clearance (GO:0034383)2.83867485
86negative regulation of cell size (GO:0045792)2.83615203
87regulation of dendritic spine development (GO:0060998)2.83490451
88vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.82850066
89response to auditory stimulus (GO:0010996)2.81611619
90L-amino acid import (GO:0043092)2.80782321
91regulation of neurotransmitter uptake (GO:0051580)2.80494017
92positive regulation of neurotransmitter transport (GO:0051590)2.79916117
93cyclic nucleotide catabolic process (GO:0009214)2.79650350
94endocytic recycling (GO:0032456)2.78770253
95regulation of voltage-gated calcium channel activity (GO:1901385)2.78278056
96glutamate secretion (GO:0014047)2.78079564
97mating behavior (GO:0007617)2.77747857
98regulation of Rap GTPase activity (GO:0032317)2.75559415
99peristalsis (GO:0030432)2.75363220
100positive regulation of Rap GTPase activity (GO:0032854)2.74424063
101adhesion of symbiont to host (GO:0044406)2.74245280
102activation of protein kinase A activity (GO:0034199)2.74203426
103apoptotic cell clearance (GO:0043277)2.72699581
104transmission of nerve impulse (GO:0019226)2.72345429
105regulation of synaptic vesicle exocytosis (GO:2000300)2.72328431
106regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.72000433
107positive regulation of synaptic transmission, GABAergic (GO:0032230)2.70812551
108long-term memory (GO:0007616)2.70193887
109neurotransmitter secretion (GO:0007269)2.69651512
110regulation of synaptic transmission, glutamatergic (GO:0051966)2.69557823
111virion attachment to host cell (GO:0019062)2.67417482
112adhesion of symbiont to host cell (GO:0044650)2.67417482
113cell adhesion mediated by integrin (GO:0033627)2.66801424
114neuron-neuron synaptic transmission (GO:0007270)2.65465277
115response to laminar fluid shear stress (GO:0034616)2.63737482
116positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.63325440
117exploration behavior (GO:0035640)2.62596641
118cell-cell junction maintenance (GO:0045217)2.62556114
119positive regulation of endothelial cell apoptotic process (GO:2000353)2.62529333
120regulation of postsynaptic membrane potential (GO:0060078)2.61930529
121protein heterotrimerization (GO:0070208)2.60818592
122cAMP metabolic process (GO:0046058)2.60631355
123visual learning (GO:0008542)2.60190008
124cell volume homeostasis (GO:0006884)2.59981072
125sodium ion export (GO:0071436)2.59077034
126axon ensheathment (GO:0008366)2.58798683
127ensheathment of neurons (GO:0007272)2.58798683
128positive regulation of membrane potential (GO:0045838)2.58599431
129endodermal cell differentiation (GO:0035987)2.57886281
130regulation of apoptotic process involved in morphogenesis (GO:1902337)2.57249891
131renal filtration (GO:0097205)2.56782566
132regulation of dopamine uptake involved in synaptic transmission (GO:0051584)2.56694870
133regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)2.56694870
134nerve growth factor signaling pathway (GO:0038180)2.56008413
135myelination (GO:0042552)2.55575102
136regulation of ARF protein signal transduction (GO:0032012)2.54331755
137negative regulation of amino acid transport (GO:0051956)2.54296461
138retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.53930354
139regulation of integrin activation (GO:0033623)2.53661369
140negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.53382553
141protein localization to synapse (GO:0035418)2.53370436
142dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.52637384
143neuromuscular process (GO:0050905)2.52586776
144branching involved in mammary gland duct morphogenesis (GO:0060444)2.52576901
145actin filament depolymerization (GO:0030042)2.51736476
146regulation of extracellular matrix organization (GO:1903053)2.50086851
147vascular endothelial growth factor signaling pathway (GO:0038084)2.50043379
148membrane tubulation (GO:0097320)2.49525395
149pinocytosis (GO:0006907)2.48552925
150adult walking behavior (GO:0007628)2.48176149
151myelin maintenance (GO:0043217)2.47868172
152synaptic transmission, glutamatergic (GO:0035249)2.47810161
153female mating behavior (GO:0060180)2.46701525
154actin filament bundle assembly (GO:0051017)2.46122778
155actin filament bundle organization (GO:0061572)2.46122778
156positive regulation of protein dephosphorylation (GO:0035307)2.46113415
157activation of MAPKKK activity (GO:0000185)2.45004180
158long-term synaptic potentiation (GO:0060291)2.44984822
159neuromuscular process controlling posture (GO:0050884)2.44957141
160regulation of membrane protein ectodomain proteolysis (GO:0051043)2.43698670
161protein targeting to plasma membrane (GO:0072661)2.43181282
162cellular potassium ion homeostasis (GO:0030007)2.42142891
163visual behavior (GO:0007632)2.41936627
164positive regulation of fibroblast migration (GO:0010763)2.41869415
165endothelial cell morphogenesis (GO:0001886)2.40274774
166glutamate receptor signaling pathway (GO:0007215)2.40212112
167planar cell polarity pathway involved in neural tube closure (GO:0090179)2.39951651
168positive regulation of neurotransmitter secretion (GO:0001956)2.38460718
169glucose 6-phosphate metabolic process (GO:0051156)2.35687018
170cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.35144548
171hyaluronan catabolic process (GO:0030214)2.34172959
172negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)2.33233639
173Rho protein signal transduction (GO:0007266)2.31927646
174negative regulation of viral release from host cell (GO:1902187)2.31577955
175negative regulation of focal adhesion assembly (GO:0051895)2.25597754
176negative regulation of cell junction assembly (GO:1901889)2.25597754
177negative regulation of adherens junction organization (GO:1903392)2.25597754
178modulation by symbiont of host cellular process (GO:0044068)2.22230545
179positive regulation of osteoblast proliferation (GO:0033690)2.21872591
180urea cycle (GO:0000050)2.20643283
181endoplasmic reticulum calcium ion homeostasis (GO:0032469)2.20054923
182embryonic process involved in female pregnancy (GO:0060136)2.19865374
183regulation of mammary gland epithelial cell proliferation (GO:0033599)2.18806473
184hypotonic response (GO:0006971)2.18606934
185insulin-like growth factor receptor signaling pathway (GO:0048009)2.18524792
186receptor catabolic process (GO:0032801)2.17238333
187positive regulation of histone deacetylation (GO:0031065)2.16181810
188positive regulation of establishment of protein localization to plasma membrane (GO:0090004)2.16076164
189positive regulation of protein localization to plasma membrane (GO:1903078)2.15772005
190regulation of fatty acid beta-oxidation (GO:0031998)2.13991086
191regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.12273344
192positive regulation of pseudopodium assembly (GO:0031274)2.12167410
193fibril organization (GO:0097435)2.11606297
194activation of JUN kinase activity (GO:0007257)2.11437962

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* RARB_27405468_Chip-Seq_BRAIN_Mouse2.92806274
2TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.58655399
3MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.50505135
4SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.47766382
5EZH2_22144423_ChIP-Seq_EOC_Human2.45477182
6DROSHA_22980978_ChIP-Seq_HELA_Human2.42359305
7SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.37327074
8PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.35835562
9RNF2_18974828_ChIP-Seq_MESCs_Mouse2.31148856
10EZH2_18974828_ChIP-Seq_MESCs_Mouse2.31148856
11MTF2_20144788_ChIP-Seq_MESCs_Mouse2.24305468
12EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.20093648
13ZNF263_19887448_ChIP-Seq_K562_Human2.19620438
14SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.16242255
15JARID2_20064375_ChIP-Seq_MESCs_Mouse2.11627656
16SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.10551068
17NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.10331333
18JARID2_20075857_ChIP-Seq_MESCs_Mouse2.09561293
19VDR_21846776_ChIP-Seq_THP-1_Human2.07877532
20SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.07620905
21SUZ12_27294783_Chip-Seq_ESCs_Mouse1.91053917
22* TCF7_22412390_ChIP-Seq_EML_Mouse1.85938104
23ERG_21242973_ChIP-ChIP_JURKAT_Human1.82063253
24SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.81587968
25KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.80265041
26* EZH2_27294783_Chip-Seq_ESCs_Mouse1.77051190
27VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.76803028
28* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.75893102
29IKZF1_21737484_ChIP-ChIP_HCT116_Human1.74376110
30TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.74337110
31* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.73543620
32UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.72222991
33KDM2B_26808549_Chip-Seq_K562_Human1.71988776
34* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.71889564
35RNF2_27304074_Chip-Seq_ESCs_Mouse1.71214975
36WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.71014182
37CLOCK_20551151_ChIP-Seq_293T_Human1.67766101
38MYC_22102868_ChIP-Seq_BL_Human1.67749361
39TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.66353576
40AR_21572438_ChIP-Seq_LNCaP_Human1.64006311
41THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.62434845
42EZH2_27304074_Chip-Seq_ESCs_Mouse1.61744556
43ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.60150814
44STAT6_21828071_ChIP-Seq_BEAS2B_Human1.60059886
45ESR1_21235772_ChIP-Seq_MCF-7_Human1.59707019
46ESR2_21235772_ChIP-Seq_MCF-7_Human1.55698885
47GBX2_23144817_ChIP-Seq_PC3_Human1.55018858
48EED_16625203_ChIP-ChIP_MESCs_Mouse1.54527230
49RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.54145288
50* DNAJC2_21179169_ChIP-ChIP_NT2_Human1.51780424
51TRIM28_21343339_ChIP-Seq_HEK293_Human1.49165534
52* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.46427197
53* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.45201384
54REST_21632747_ChIP-Seq_MESCs_Mouse1.42413832
55TET1_21451524_ChIP-Seq_MESCs_Mouse1.41381676
56ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.41043616
57CTCF_27219007_Chip-Seq_ERYTHROID_Human1.40366097
58ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.39264055
59P68_20966046_ChIP-Seq_HELA_Human1.38577893
60EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.35888247
61NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.35563638
62ATF3_27146783_Chip-Seq_COLON_Human1.35390902
63KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.33679294
64RUNX1_27514584_Chip-Seq_MCF-7_Human1.32971784
65SA1_27219007_Chip-Seq_ERYTHROID_Human1.32949236
66LXR_22292898_ChIP-Seq_THP-1_Human1.31339408
67TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.30388483
68VDR_24763502_ChIP-Seq_THP-1_Human1.30166094
69ZFP281_18757296_ChIP-ChIP_E14_Mouse1.30030017
70EGR1_19374776_ChIP-ChIP_THP-1_Human1.28229561
71REST_18959480_ChIP-ChIP_MESCs_Mouse1.27044569
72HIF1A_21447827_ChIP-Seq_MCF-7_Human1.25100574
73TP53_22127205_ChIP-Seq_IMR90_Human1.24827590
74SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.24361569
75SRY_22984422_ChIP-ChIP_TESTIS_Rat1.23076679
76* GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.21528345
77* CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.20534163
78ZNF217_24962896_ChIP-Seq_MCF-7_Human1.19605243
79* P63_26484246_Chip-Seq_KERATINOCYTES_Human1.18632538
80NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.18524587
81* KDM2B_26808549_Chip-Seq_DND41_Human1.16991440
82* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.16213896
83UBF1/2_26484160_Chip-Seq_HMECs_Human1.16105367
84ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.15895784
85SOX2_27498859_Chip-Seq_STOMACH_Mouse1.15203776
86* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.15183904
87* RXR_22158963_ChIP-Seq_LIVER_Mouse1.15013747
88* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.13402636
89* LXR_22158963_ChIP-Seq_LIVER_Mouse1.13110224
90TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.13101240
91* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.12902187
92ZFP281_27345836_Chip-Seq_ESCs_Mouse1.11975466
93* RARG_19884340_ChIP-ChIP_MEFs_Mouse1.11631192
94SMC1_22415368_ChIP-Seq_MEFs_Mouse1.10632452
95SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.10606286
96CDX2_20551321_ChIP-Seq_CACO-2_Human1.10398005
97SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.09563271
98SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.09563271
99CDX2_19796622_ChIP-Seq_MESCs_Mouse1.09353724
100TP53_16413492_ChIP-PET_HCT116_Human1.09050498
101ESR1_20079471_ChIP-ChIP_T-47D_Human1.08792799
102SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.08014145
103RING1B_27294783_Chip-Seq_ESCs_Mouse1.07463201
104KDM2B_26808549_Chip-Seq_JURKAT_Human1.06448911
105BRD4_27068464_Chip-Seq_AML-cells_Mouse1.05746665
106* CTCF_27219007_Chip-Seq_Bcells_Human1.05730380
107TP63_17297297_ChIP-ChIP_HaCaT_Human1.04563819
108FOXA2_19822575_ChIP-Seq_HepG2_Human1.04490849
109GATA1_19941827_ChIP-Seq_MEL_Mouse1.04460350
110TP63_22573176_ChIP-Seq_HFKS_Human1.03976309
111DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.03700881
112TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.03441010
113SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.02921838
114* RUNX1_22412390_ChIP-Seq_EML_Mouse1.02230718
115NCOR1_26117541_ChIP-Seq_K562_Human1.01390169
116BCOR_27268052_Chip-Seq_Bcells_Human1.00447303
117RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.00196330
118AHR_22903824_ChIP-Seq_MCF-7_Human0.99747375
119* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.99219177
120FOXO3_23340844_ChIP-Seq_DLD1_Human0.99061024
121NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.98536085
122SMAD3_21741376_ChIP-Seq_HESCs_Human0.98382666
123TET1_21490601_ChIP-Seq_MESCs_Mouse0.98265080
124RING1B_27294783_Chip-Seq_NPCs_Mouse0.97818755
125GATA1_22383799_ChIP-Seq_G1ME_Mouse0.97534948
126* TBX20_22328084_ChIP-Seq_HEART_Mouse0.97465927
127* TBX20_22080862_ChIP-Seq_HEART_Mouse0.97465927
128KLF4_19829295_ChIP-Seq_ESCs_Human0.96689133
129RXR_22108803_ChIP-Seq_LS180_Human0.96250334
130EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.93437367
131DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.93390944
132GATA1_19941826_ChIP-Seq_K562_Human0.92615428
133BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.91986540
134EP300_21415370_ChIP-Seq_HL-1_Mouse0.91703242
135* P300_27058665_Chip-Seq_ZR-75-30cells_Human0.91030231
136* RACK7_27058665_Chip-Seq_MCF-7_Human0.90639618
137* KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.90200498
138FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.89251521
139PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.88746987
140* ELK3_25401928_ChIP-Seq_HUVEC_Human0.88327419
141* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.88316117
142* NRF2_20460467_ChIP-Seq_MEFs_Mouse0.88306735
143* NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.88306735
144GATA2_21666600_ChIP-Seq_HMVEC_Human0.86337730
145PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.85827581
146AR_19668381_ChIP-Seq_PC3_Human0.85794686
147CREB1_26743006_Chip-Seq_LNCaP_Human0.84711810
148SOX2_21211035_ChIP-Seq_LN229_Gbm0.84346633
149P53_22127205_ChIP-Seq_FIBROBLAST_Human0.84092830
150* PPARA_22158963_ChIP-Seq_LIVER_Mouse0.83744911
151* RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.83155871
152SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.82300558
153SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.81873212
154ARNT_22903824_ChIP-Seq_MCF-7_Human0.81733657
155SMAD_19615063_ChIP-ChIP_OVARY_Human0.81112736
156TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.80915729
157SOX9_24532713_ChIP-Seq_HFSC_Mouse0.80465971
158* SMC4_20622854_ChIP-Seq_HELA_Human0.80006236
159TP53_20018659_ChIP-ChIP_R1E_Mouse0.79756289
160NR3C1_23031785_ChIP-Seq_PC12_Mouse0.79342449

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002822_catalepsy7.29995252
2MP0004859_abnormal_synaptic_plasticity5.92696441
3MP0003635_abnormal_synaptic_transmissio3.22961583
4MP0003880_abnormal_central_pattern2.93292877
5MP0003566_abnormal_cell_adhesion2.93015284
6MP0009745_abnormal_behavioral_response2.86786418
7MP0004270_analgesia2.84092619
8MP0002063_abnormal_learning/memory/cond2.63458346
9MP0002064_seizures2.51177023
10MP0003329_amyloid_beta_deposits2.48295369
11MP0001849_ear_inflammation2.46694425
12MP0000920_abnormal_myelination2.45784620
13MP0004272_abnormal_basement_membrane2.35535216
14MP0005076_abnormal_cell_differentiation2.25431509
15MP0001486_abnormal_startle_reflex2.17528921
16MP0003191_abnormal_cellular_cholesterol2.17381809
17MP0003690_abnormal_glial_cell2.13777711
18MP0005451_abnormal_body_composition2.09607437
19MP0005257_abnormal_intraocular_pressure2.08700463
20MP0002877_abnormal_melanocyte_morpholog2.07538663
21MP0003075_altered_response_to2.05226700
22MP0009046_muscle_twitch2.01414861
23MP0002272_abnormal_nervous_system2.00667822
24MP0002572_abnormal_emotion/affect_behav1.96844358
25MP0005623_abnormal_meninges_morphology1.86622102
26MP0005670_abnormal_white_adipose1.85462014
27MP0008438_abnormal_cutaneous_collagen1.81465505
28MP0000604_amyloidosis1.69657221
29MP0003705_abnormal_hypodermis_morpholog1.68656674
30MP0005666_abnormal_adipose_tissue1.67899229
31MP0002060_abnormal_skin_morphology1.66266107
32MP0001529_abnormal_vocalization1.63737479
33MP0001501_abnormal_sleep_pattern1.62865548
34MP0002909_abnormal_adrenal_gland1.60897409
35MP0008569_lethality_at_weaning1.60368663
36MP0008260_abnormal_autophagy1.58317479
37MP0008874_decreased_physiological_sensi1.56893475
38MP0005423_abnormal_somatic_nervous1.56452918
39MP0005167_abnormal_blood-brain_barrier1.51887993
40MP0004885_abnormal_endolymph1.51598644
41MP0004947_skin_inflammation1.49633359
42MP0010234_abnormal_vibrissa_follicle1.49615932
43MP0009780_abnormal_chondrocyte_physiolo1.47549529
44MP0003633_abnormal_nervous_system1.45909752
45MP0000858_altered_metastatic_potential1.44956324
46MP0001968_abnormal_touch/_nociception1.44474967
47MP0010368_abnormal_lymphatic_system1.42088054
48MP0010352_gastrointestinal_tract_polyps1.39403369
49MP0000013_abnormal_adipose_tissue1.39283614
50MP0002139_abnormal_hepatobiliary_system1.36101243
51MP0002734_abnormal_mechanical_nocicepti1.33100863
52MP0000767_abnormal_smooth_muscle1.32482627
53MP0009840_abnormal_foam_cell1.31637041
54MP0004811_abnormal_neuron_physiology1.31183038
55MP0001177_atelectasis1.29176073
56MP0005501_abnormal_skin_physiology1.28787424
57MP0005409_darkened_coat_color1.28502110
58MP0001348_abnormal_lacrimal_gland1.28339515
59MP0003436_decreased_susceptibility_to1.28205339
60MP0002089_abnormal_postnatal_growth/wei1.26596295
61MP0001970_abnormal_pain_threshold1.26459115
62MP0004858_abnormal_nervous_system1.24940312
63MP0002998_abnormal_bone_remodeling1.23280240
64MP0003631_nervous_system_phenotype1.22218304
65MP0003634_abnormal_glial_cell1.21677013
66MP0004924_abnormal_behavior1.20819626
67MP0005386_behavior/neurological_phenoty1.20819626
68MP0002733_abnormal_thermal_nociception1.20093583
69MP0003091_abnormal_cell_migration1.19548059
70MP0001440_abnormal_grooming_behavior1.18464573
71MP0002896_abnormal_bone_mineralization1.13355262
72MP0000678_abnormal_parathyroid_gland1.11016051
73MP0000751_myopathy1.10525442
74MP0002090_abnormal_vision1.09642613
75MP0000733_abnormal_muscle_development1.09015987
76MP0006138_congestive_heart_failure1.08795030
77MP0005595_abnormal_vascular_smooth1.08220393
78MP0005275_abnormal_skin_tensile1.07264023
79MP0000003_abnormal_adipose_tissue1.04865256
80MP0000579_abnormal_nail_morphology1.04443698
81MP0002066_abnormal_motor_capabilities/c1.04186216
82MP0005085_abnormal_gallbladder_physiolo1.03767880
83MP0000467_abnormal_esophagus_morphology1.03265008
84MP0004264_abnormal_extraembryonic_tissu1.02777427
85MP0000955_abnormal_spinal_cord1.02144381
86MP0001216_abnormal_epidermal_layer1.02001605
87MP0010678_abnormal_skin_adnexa1.01283574
88MP0003300_gastrointestinal_ulcer0.98761534
89MP0008961_abnormal_basal_metabolism0.98036840
90MP0002254_reproductive_system_inflammat0.97850620
91MP0003303_peritoneal_inflammation0.96879726
92MP0003632_abnormal_nervous_system0.96432347
93MP0005464_abnormal_platelet_physiology0.95955128
94MP0003879_abnormal_hair_cell0.95381183
95MP0003448_altered_tumor_morphology0.95290321
96MP0000537_abnormal_urethra_morphology0.94816397
97MP0000747_muscle_weakness0.94363641
98MP0005503_abnormal_tendon_morphology0.94275825
99MP0003172_abnormal_lysosome_physiology0.94079028
100MP0001533_abnormal_skeleton_physiology0.93395372
101MP0008872_abnormal_physiological_respon0.92705041
102MP0009384_cardiac_valve_regurgitation0.92695441
103MP0005508_abnormal_skeleton_morphology0.91302947
104MP0002249_abnormal_larynx_morphology0.91123243
105MP0005646_abnormal_pituitary_gland0.90483343
106MP0001243_abnormal_dermal_layer0.88959783
107MP0010030_abnormal_orbit_morphology0.88908726
108MP0002933_joint_inflammation0.88179900
109MP0000249_abnormal_blood_vessel0.88010780
110MP0005165_increased_susceptibility_to0.87398356
111MP0010155_abnormal_intestine_physiology0.86701870
112MP0003045_fibrosis0.86418257
113MP0003828_pulmonary_edema0.86315757
114MP0001346_abnormal_lacrimal_gland0.86187225
115MP0009278_abnormal_bone_marrow0.86075535
116MP0002736_abnormal_nociception_after0.85372212
117MP0000343_altered_response_to0.85364327
118MP0001905_abnormal_dopamine_level0.84328269
119MP0001958_emphysema0.83486790
120MP0002882_abnormal_neuron_morphology0.83382526
121MP0003283_abnormal_digestive_organ0.83278961
122MP0005058_abnormal_lysosome_morphology0.83041656
123MP0005390_skeleton_phenotype0.82517988
124MP0008004_abnormal_stomach_pH0.82487774
125MP0005621_abnormal_cell_physiology0.82152259
126MP0005166_decreased_susceptibility_to0.81613107
127MP0005360_urolithiasis0.80916238
128MP0002557_abnormal_social/conspecific_i0.79959594
129MP0009931_abnormal_skin_appearance0.79430069
130MP0002067_abnormal_sensory_capabilities0.79212906
131MP0004085_abnormal_heartbeat0.76820144
132MP0004510_myositis0.75739092
133MP0003183_abnormal_peptide_metabolism0.75566024
134MP0002796_impaired_skin_barrier0.75248864
135MP0005164_abnormal_response_to0.74781805
136MP0010771_integument_phenotype0.74074925
137MP0002098_abnormal_vibrissa_morphology0.74065499
138MP0004142_abnormal_muscle_tone0.73909847
139MP0002295_abnormal_pulmonary_circulatio0.72597518
140MP0005584_abnormal_enzyme/coenzyme_acti0.72413999
141MP0001299_abnormal_eye_distance/0.72307958
142MP0002971_abnormal_brown_adipose0.72253776
143MP0003279_aneurysm0.71782325
144MP0000759_abnormal_skeletal_muscle0.71717653
145MP0000762_abnormal_tongue_morphology0.69577480
146MP0002970_abnormal_white_adipose0.69368041
147MP0003195_calcinosis0.69214129
148MP0010329_abnormal_lipoprotein_level0.69093139
149MP0002229_neurodegeneration0.69010380
150MP0003453_abnormal_keratinocyte_physiol0.68646397
151MP0000462_abnormal_digestive_system0.68416607
152MP0002069_abnormal_eating/drinking_beha0.68138572
153MP0002118_abnormal_lipid_homeostasis0.68135120
154MP0001542_abnormal_bone_strength0.68043723
155MP0005365_abnormal_bile_salt0.67921912
156MP0005535_abnormal_body_temperature0.67794204
157MP0000778_abnormal_nervous_system0.67470147
158MP0000566_synostosis0.66671949
159MP0005375_adipose_tissue_phenotype0.65121312
160MP0004185_abnormal_adipocyte_glucose0.65032607
161MP0004130_abnormal_muscle_cell0.64503128
162MP0005023_abnormal_wound_healing0.64432392
163MP0000569_abnormal_digit_pigmentation0.63829489
164MP0003950_abnormal_plasma_membrane0.62295910

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)6.73014243
2Focal motor seizures (HP:0011153)4.30788290
3Neurofibrillary tangles (HP:0002185)3.97166226
4Torticollis (HP:0000473)3.74683048
5Focal seizures (HP:0007359)3.70982217
6Cerebral inclusion bodies (HP:0100314)3.55414370
7Supranuclear gaze palsy (HP:0000605)3.44191295
8Action tremor (HP:0002345)3.42629668
9Resting tremor (HP:0002322)3.29068622
10Ankle clonus (HP:0011448)3.24780097
11Broad face (HP:0000283)3.23964835
12Cervical subluxation (HP:0003308)3.19504082
13Annular pancreas (HP:0001734)3.12784676
14Hyperacusis (HP:0010780)3.12181476
15Craniofacial dystonia (HP:0012179)3.11741898
16Increased connective tissue (HP:0009025)3.11018150
17Fragile skin (HP:0001030)3.10022856
18Focal dystonia (HP:0004373)3.08908154
19Premature rupture of membranes (HP:0001788)3.04608456
20Dysmetria (HP:0001310)2.98842277
21Vertebral compression fractures (HP:0002953)2.93942295
22Thin bony cortex (HP:0002753)2.93622797
23Obstructive sleep apnea (HP:0002870)2.83548407
24Achilles tendon contracture (HP:0001771)2.83137888
25Intention tremor (HP:0002080)2.83047718
26Abnormality of the Achilles tendon (HP:0005109)2.79872254
27Mildly elevated creatine phosphokinase (HP:0008180)2.75033512
28Abnormal social behavior (HP:0012433)2.68811105
29Impaired social interactions (HP:0000735)2.68811105
30Hemorrhage of the eye (HP:0011885)2.64485900
31Poor eye contact (HP:0000817)2.63754579
32Spastic gait (HP:0002064)2.63614193
33Dysdiadochokinesis (HP:0002075)2.62658294
34Insidious onset (HP:0003587)2.62395318
35Termporal pattern (HP:0011008)2.62395318
36Distal lower limb muscle weakness (HP:0009053)2.60965455
37Protrusio acetabuli (HP:0003179)2.60226580
38Deep venous thrombosis (HP:0002625)2.60122996
39Turricephaly (HP:0000262)2.59926386
40Scanning speech (HP:0002168)2.58810179
41Ankyloglossia (HP:0010296)2.57584309
42Impaired vibration sensation in the lower limbs (HP:0002166)2.57315993
43Urinary urgency (HP:0000012)2.56854312
44Postural instability (HP:0002172)2.52367480
45* Onion bulb formation (HP:0003383)2.51344495
46Spinal rigidity (HP:0003306)2.50509468
47Anxiety (HP:0000739)2.48676151
48Arterial tortuosity (HP:0005116)2.48102655
49Ulnar bowing (HP:0003031)2.47311388
50Vascular tortuosity (HP:0004948)2.46551049
51Urinary bladder sphincter dysfunction (HP:0002839)2.43070761
52Polygenic inheritance (HP:0010982)2.42848811
53Nuclear cataract (HP:0100018)2.41414918
54J-shaped sella turcica (HP:0002680)2.39767281
55Aortic aneurysm (HP:0004942)2.39476215
56Dysostosis multiplex (HP:0000943)2.38815570
57Depression (HP:0000716)2.37181776
58Atrioventricular block (HP:0001678)2.34057661
59Stridor (HP:0010307)2.32645916
60Abnormality of the periventricular white matter (HP:0002518)2.28731015
61Wormian bones (HP:0002645)2.28362431
62Aplasia involving bones of the extremities (HP:0009825)2.28197796
63Aplasia involving bones of the upper limbs (HP:0009823)2.28197796
64Aplasia of the phalanges of the hand (HP:0009802)2.28197796
65Aneurysm (HP:0002617)2.26139316
66Hyporeflexia of lower limbs (HP:0002600)2.26133882
67Megalencephaly (HP:0001355)2.25777113
68Increased variability in muscle fiber diameter (HP:0003557)2.25612342
69Aortic dissection (HP:0002647)2.25404311
70Neuronal loss in central nervous system (HP:0002529)2.25130158
71Mitral regurgitation (HP:0001653)2.23219524
72Degeneration of the lateral corticospinal tracts (HP:0002314)2.21643347
73Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.21643347
74Pointed chin (HP:0000307)2.21623072
75Flat acetabular roof (HP:0003180)2.21414413
76Ankle contracture (HP:0006466)2.21137814
77Broad metatarsal (HP:0001783)2.20260136
78Abnormality of oral frenula (HP:0000190)2.19450078
79Peritonitis (HP:0002586)2.18539813
80Dysmetric saccades (HP:0000641)2.18225334
81Osteolytic defects of the hand bones (HP:0009699)2.15707157
82Osteolytic defects of the phalanges of the hand (HP:0009771)2.15707157
83Spastic tetraparesis (HP:0001285)2.15004540
84Short nail (HP:0001799)2.13852661
85Disproportionate tall stature (HP:0001519)2.13823363
86Bladder diverticulum (HP:0000015)2.13744518
87Amyloidosis (HP:0011034)2.13582035
88Mucopolysacchariduria (HP:0008155)2.13061780
89Urinary glycosaminoglycan excretion (HP:0003541)2.13061780
90Malnutrition (HP:0004395)2.13012226
91Shallow orbits (HP:0000586)2.12599601
92Blue sclerae (HP:0000592)2.11938261
93Difficulty running (HP:0009046)2.11548274
94Clonus (HP:0002169)2.08976824
95Rapidly progressive (HP:0003678)2.08741553
96Systemic lupus erythematosus (HP:0002725)2.08014221
97Difficulty climbing stairs (HP:0003551)2.07654748
98Spondylolisthesis (HP:0003302)2.07649977
99Abnormality of mucopolysaccharide metabolism (HP:0011020)2.07520645
100Abnormality of polysaccharide metabolism (HP:0011012)2.07520645
101Abnormality of glycosaminoglycan metabolism (HP:0004371)2.07520645
102Generalized tonic-clonic seizures (HP:0002069)2.06306962
103Lower limb muscle weakness (HP:0007340)2.04585074
104Abnormality of the corticospinal tract (HP:0002492)2.02925067
105Abnormality of liposaccharide metabolism (HP:0010968)2.02732825
106Abnormality of glycosphingolipid metabolism (HP:0004343)2.02732825
107Abnormality of glycolipid metabolism (HP:0010969)2.02732825
108Abnormal atrioventricular conduction (HP:0005150)2.02407015
109Bronchomalacia (HP:0002780)2.01630092
110Visual hallucinations (HP:0002367)2.00704517
111Peripheral hypomyelination (HP:0007182)1.99465367
112Hemiplegia (HP:0002301)1.99169062
113Heart block (HP:0012722)1.98561525
114Joint stiffness (HP:0001387)1.98294261
115Abnormality of complement system (HP:0005339)1.97636903
116Xanthomatosis (HP:0000991)1.97109141
117Cerebral aneurysm (HP:0004944)1.96774118
118Stereotypic behavior (HP:0000733)1.96192174
119Abnormality of the lower motor neuron (HP:0002366)1.94868341
120Generalized amyotrophy (HP:0003700)1.94452508
121Hand muscle atrophy (HP:0009130)1.93156922
122Milia (HP:0001056)1.91909441
123Acanthosis nigricans (HP:0000956)1.91584776
124Hypertriglyceridemia (HP:0002155)1.89738639
125Myocardial infarction (HP:0001658)1.88211071
126Epileptic encephalopathy (HP:0200134)1.87850596
127Dilatation of the ascending aorta (HP:0005111)1.87123165
128Abnormality of saccadic eye movements (HP:0000570)1.85970957
129* Distal upper limb amyotrophy (HP:0007149)1.85840735
130* Upper limb amyotrophy (HP:0009129)1.85840735
131Atrophic scars (HP:0001075)1.85065754
132Slow saccadic eye movements (HP:0000514)1.84341345
133Insomnia (HP:0100785)1.84181057
134Broad-based gait (HP:0002136)1.82590165
135Biconcave vertebral bodies (HP:0004586)1.82304965
136Buphthalmos (HP:0000557)1.81887262
137Infantile muscular hypotonia (HP:0008947)1.81639646
138Aortic regurgitation (HP:0001659)1.81316029
139Genu recurvatum (HP:0002816)1.81290346
140Abnormality of skeletal muscle fiber size (HP:0012084)1.80802941
141Impaired vibratory sensation (HP:0002495)1.79772402
142Gaze-evoked nystagmus (HP:0000640)1.78457662
143Coxa vara (HP:0002812)1.78137206
144Increased cerebral lipofuscin (HP:0011813)1.78109205
145Natal tooth (HP:0000695)1.77888478
146Mitral valve prolapse (HP:0001634)1.77430149
147Right ventricular cardiomyopathy (HP:0011663)1.77224489
148Hyperparathyroidism (HP:0000843)1.76983658
149Elbow flexion contracture (HP:0002987)1.75929991
150Advanced eruption of teeth (HP:0006288)1.75891098
151Easy fatigability (HP:0003388)1.75457035
152Abdominal distention (HP:0003270)1.75100239
153Rigidity (HP:0002063)1.74310370
154Centrally nucleated skeletal muscle fibers (HP:0003687)1.74289762
155Abnormality of the distal phalanges of the toes (HP:0010182)1.74040566
156Interstitial pulmonary disease (HP:0006530)1.73932017
157Prolonged QT interval (HP:0001657)1.72225881
158Hyperlipoproteinemia (HP:0010980)1.71953170
159Papilledema (HP:0001085)1.71203216
160Sensory axonal neuropathy (HP:0003390)1.70264576
161* Distal lower limb amyotrophy (HP:0008944)1.70250989
162Abnormality of monocarboxylic acid metabolism (HP:0010996)1.70066534
163Dialeptic seizures (HP:0011146)1.69615268
164Scapular winging (HP:0003691)1.69334525
165Lymphangioma (HP:0100764)1.68450544
166Status epilepticus (HP:0002133)1.67690357
167Bone pain (HP:0002653)1.66924729
168Abnormal eating behavior (HP:0100738)1.66493187
169Trismus (HP:0000211)1.66225277
170Slow progression (HP:0003677)1.66223309
171Spinal cord compression (HP:0002176)1.66196219
172Bowel incontinence (HP:0002607)1.65760711
173Absence seizures (HP:0002121)1.65634996
174Bradykinesia (HP:0002067)1.64943429
175Bundle branch block (HP:0011710)1.63399029
176Menorrhagia (HP:0000132)1.60514339
177Abnormality of the acetabulum (HP:0003170)1.60425923
178Joint laxity (HP:0001388)1.60322859
179Abnormal ossification of hand bones (HP:0005921)1.60256444
180Neonatal death (HP:0003811)1.59477670
181Long palpebral fissure (HP:0000637)1.59368180

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA46.26917302
2MST1R4.00284420
3EPHA23.96965464
4IRAK32.88588581
5MAP3K92.76550005
6KSR22.70508101
7NTRK32.58468428
8PRKD32.56683798
9DAPK22.50799226
10MAP3K132.32588854
11TRIB32.27587480
12NTRK12.27109458
13RIPK42.06496060
14LMTK22.05524660
15CAMKK12.02795049
16PAK62.02331255
17SMG11.99641790
18NME21.75588577
19TYRO31.66812761
20TAOK11.65604806
21TESK11.64056398
22FES1.59221186
23EPHB11.58040965
24PAK41.56522087
25MAP3K21.46840739
26BMX1.41736700
27ARAF1.41077868
28CDK51.38988048
29FGFR41.34627526
30EEF2K1.34390551
31DDR21.30225382
32STK391.28493404
33CDK121.27144659
34SIK21.26355009
35MINK11.25305700
36EPHB21.24874506
37RIPK11.24476341
38TAOK21.23448142
39PRKCH1.23365314
40MARK21.21373165
41MAP3K31.21231214
42PTK2B1.20952555
43PDGFRA1.14694464
44PDPK11.11184899
45MAP3K111.07489540
46MAP2K31.04411038
47MOS1.03888461
48PRPF4B1.03515336
49RET1.02776332
50NTRK21.02624225
51PRKG21.02506797
52TTN1.00669381
53OXSR10.98055709
54MTOR0.97957852
55WNK10.94887070
56DMPK0.94869071
57MAP3K70.94153091
58ALK0.92294951
59FGFR20.92280214
60STK380.89662887
61CAMK2B0.89259211
62SGK2230.87769113
63SGK4940.87769113
64TBK10.87480760
65MAP3K10.87263229
66PRKD20.86598741
67DAPK30.86474652
68ICK0.85011792
69ERN10.84945808
70CDK150.84071057
71KSR10.82196801
72PDK10.82033992
73STK110.81518248
74RAF10.80453757
75RPS6KA20.80171573
76TGFBR20.79458877
77MYLK0.79159832
78PRKD10.78818798
79UHMK10.78565139
80CDK140.78353039
81MAP3K60.77872863
82MAP2K10.77826157
83MAPKAPK50.77745802
84CDK180.77675170
85PAK30.76855664
86ZAP700.75570723
87ROCK20.74958346
88MAP3K40.74615815
89CDK11A0.72665357
90PIM20.72477146
91PTK20.72076920
92DAPK10.70293146
93PKN20.70117610
94PKN10.70031914
95FGR0.69165628
96MAP3K100.68775456
97FYN0.67840517
98CAMKK20.67557879
99TNK20.67486937
100SIK10.65372752
101CAMK10.64940265
102MET0.64242389
103CAMK2A0.64110811
104SGK10.63301891
105MAPK110.63238652
106CAMK1G0.62838307
107LIMK10.61905159
108TESK20.61293166
109MAP2K40.60748512
110IRAK20.60316750
111HCK0.59175823
112CAMK2G0.59164293
113SIK30.58822533
114PDGFRB0.57543241
115SGK30.56271591
116LATS20.56008209
117MAPKAPK30.55055307
118ABL20.54809668
119CDK190.54174472
120CAMK2D0.53677216
121PAK20.52252452
122HIPK20.51437559
123PTK60.51130084
124PINK10.49764929
125ILK0.48986766
126CDC42BPA0.48681195
127RPS6KA30.48225680
128MAP4K10.47909145
129PRKCG0.47732759
130LRRK20.47360560
131RPS6KL10.46368247
132RPS6KC10.46368247
133PRKCZ0.45627818
134MAP3K140.45563697
135MAP2K20.44509508
136PRKCQ0.44337677
137MAPK100.42998649
138SRC0.42463317
139CLK10.42451110
140TYK20.41454768
141MAPK120.41307994
142NEK60.40866006
143MAPK70.40478456
144MAP3K80.38332430
145TRPM70.37187619
146BRAF0.36561794
147MAPKAPK20.34882417
148CHUK0.32951393
149PAK10.30228340
150MAP2K60.29888250
151MELK0.29277284
152ROCK10.29213263

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009103.84439340
2Other glycan degradation_Homo sapiens_hsa005112.81962923
3Olfactory transduction_Homo sapiens_hsa047402.52520330
4Glycosaminoglycan degradation_Homo sapiens_hsa005312.15264884
5Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.02475002
6Cocaine addiction_Homo sapiens_hsa050302.01944299
7Morphine addiction_Homo sapiens_hsa050321.93116501
8GABAergic synapse_Homo sapiens_hsa047271.92994794
9Circadian entrainment_Homo sapiens_hsa047131.92683881
10Glutamatergic synapse_Homo sapiens_hsa047241.84933066
11Amphetamine addiction_Homo sapiens_hsa050311.80014009
12Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.79763249
13Cyanoamino acid metabolism_Homo sapiens_hsa004601.76974908
14Long-term potentiation_Homo sapiens_hsa047201.69414115
15Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.67841590
16Synaptic vesicle cycle_Homo sapiens_hsa047211.66347395
17Salivary secretion_Homo sapiens_hsa049701.63631007
18Fructose and mannose metabolism_Homo sapiens_hsa000511.60860134
19Cholinergic synapse_Homo sapiens_hsa047251.59254127
20Notch signaling pathway_Homo sapiens_hsa043301.58639472
21Dopaminergic synapse_Homo sapiens_hsa047281.58104585
22Gastric acid secretion_Homo sapiens_hsa049711.49601640
23Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.49574045
24Primary bile acid biosynthesis_Homo sapiens_hsa001201.47151097
25Aldosterone synthesis and secretion_Homo sapiens_hsa049251.46711499
26Arginine biosynthesis_Homo sapiens_hsa002201.45200352
27Renin secretion_Homo sapiens_hsa049241.43176234
28Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.39312645
29Nicotine addiction_Homo sapiens_hsa050331.37172887
30Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.36140138
31Galactose metabolism_Homo sapiens_hsa000521.35402013
32Oxytocin signaling pathway_Homo sapiens_hsa049211.34663285
33Acute myeloid leukemia_Homo sapiens_hsa052211.33042009
34Central carbon metabolism in cancer_Homo sapiens_hsa052301.32814596
35Gap junction_Homo sapiens_hsa045401.26081743
36GnRH signaling pathway_Homo sapiens_hsa049121.22137642
37Leukocyte transendothelial migration_Homo sapiens_hsa046701.18021915
38Glioma_Homo sapiens_hsa052141.16958625
39Small cell lung cancer_Homo sapiens_hsa052221.15883775
40Bile secretion_Homo sapiens_hsa049761.15460933
41Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.12995440
42Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.12637554
43Long-term depression_Homo sapiens_hsa047301.11199824
44Pentose phosphate pathway_Homo sapiens_hsa000301.10832288
45Calcium signaling pathway_Homo sapiens_hsa040201.10659869
46Phospholipase D signaling pathway_Homo sapiens_hsa040721.06776590
47Pancreatic cancer_Homo sapiens_hsa052121.06628164
48cAMP signaling pathway_Homo sapiens_hsa040241.06298355
49Insulin secretion_Homo sapiens_hsa049111.03298349
50Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.03032645
51Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.00730402
52TNF signaling pathway_Homo sapiens_hsa046680.99646506
53Vascular smooth muscle contraction_Homo sapiens_hsa042700.98482242
54Insulin signaling pathway_Homo sapiens_hsa049100.96379547
55Dilated cardiomyopathy_Homo sapiens_hsa054140.95955975
56Axon guidance_Homo sapiens_hsa043600.95845686
57Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.94903124
58Serotonergic synapse_Homo sapiens_hsa047260.93651352
59Protein digestion and absorption_Homo sapiens_hsa049740.91721883
60Adherens junction_Homo sapiens_hsa045200.91473582
61Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.89824466
62Hepatitis C_Homo sapiens_hsa051600.89422322
63Toxoplasmosis_Homo sapiens_hsa051450.88636015
64Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.88253957
65Thyroid cancer_Homo sapiens_hsa052160.87813750
66Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.87544997
67ErbB signaling pathway_Homo sapiens_hsa040120.87088966
68Rap1 signaling pathway_Homo sapiens_hsa040150.86951801
69Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.86847708
70Insulin resistance_Homo sapiens_hsa049310.85721410
71Dorso-ventral axis formation_Homo sapiens_hsa043200.85168849
72AMPK signaling pathway_Homo sapiens_hsa041520.84790267
73Osteoclast differentiation_Homo sapiens_hsa043800.84134597
74Estrogen signaling pathway_Homo sapiens_hsa049150.83934218
75Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.83537271
76Endometrial cancer_Homo sapiens_hsa052130.83137075
77Salmonella infection_Homo sapiens_hsa051320.82162285
78VEGF signaling pathway_Homo sapiens_hsa043700.81619138
79Phosphatidylinositol signaling system_Homo sapiens_hsa040700.81551369
80Vibrio cholerae infection_Homo sapiens_hsa051100.80680669
81Pertussis_Homo sapiens_hsa051330.79917069
82Toll-like receptor signaling pathway_Homo sapiens_hsa046200.79531434
83Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.76182889
84Vitamin B6 metabolism_Homo sapiens_hsa007500.76022828
85Sulfur relay system_Homo sapiens_hsa041220.75264435
86Non-small cell lung cancer_Homo sapiens_hsa052230.74884820
87cGMP-PKG signaling pathway_Homo sapiens_hsa040220.74256014
88Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.73935036
89Type II diabetes mellitus_Homo sapiens_hsa049300.73445273
90Melanogenesis_Homo sapiens_hsa049160.72621549
91Shigellosis_Homo sapiens_hsa051310.69838683
92Prion diseases_Homo sapiens_hsa050200.69186917
93Butanoate metabolism_Homo sapiens_hsa006500.69041311
94Endocytosis_Homo sapiens_hsa041440.68024590
95MicroRNAs in cancer_Homo sapiens_hsa052060.66856269
96Sphingolipid signaling pathway_Homo sapiens_hsa040710.66492448
97Amoebiasis_Homo sapiens_hsa051460.66296163
98Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.65989275
99Renal cell carcinoma_Homo sapiens_hsa052110.65928688
100Apoptosis_Homo sapiens_hsa042100.63883693
101Focal adhesion_Homo sapiens_hsa045100.63165188
102Thyroid hormone synthesis_Homo sapiens_hsa049180.62712005
103Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.62654551
104Taste transduction_Homo sapiens_hsa047420.62650196
105Ras signaling pathway_Homo sapiens_hsa040140.62574452
106Inositol phosphate metabolism_Homo sapiens_hsa005620.62460096
107Regulation of actin cytoskeleton_Homo sapiens_hsa048100.61510216
108ECM-receptor interaction_Homo sapiens_hsa045120.61456416
109Platelet activation_Homo sapiens_hsa046110.61376117
110PPAR signaling pathway_Homo sapiens_hsa033200.60935930
111Choline metabolism in cancer_Homo sapiens_hsa052310.60694314
112Malaria_Homo sapiens_hsa051440.60156992
113MAPK signaling pathway_Homo sapiens_hsa040100.60120808
1142-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.59889421
115B cell receptor signaling pathway_Homo sapiens_hsa046620.58832817
116Complement and coagulation cascades_Homo sapiens_hsa046100.57921819
117Phenylalanine metabolism_Homo sapiens_hsa003600.57327050
118Renin-angiotensin system_Homo sapiens_hsa046140.57102823
119Chemokine signaling pathway_Homo sapiens_hsa040620.56693742
120Proteoglycans in cancer_Homo sapiens_hsa052050.56462719
121Neurotrophin signaling pathway_Homo sapiens_hsa047220.54562542
122Prolactin signaling pathway_Homo sapiens_hsa049170.53492243
123Adipocytokine signaling pathway_Homo sapiens_hsa049200.52477854
124Biosynthesis of amino acids_Homo sapiens_hsa012300.52287680
125Ovarian steroidogenesis_Homo sapiens_hsa049130.51683933
126Hepatitis B_Homo sapiens_hsa051610.51601149
127Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.51424718
128HIF-1 signaling pathway_Homo sapiens_hsa040660.51078268
129Glucagon signaling pathway_Homo sapiens_hsa049220.50966396
130Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.50169443
131Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.50128235
132Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.49413008
133Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.48611491
134Bladder cancer_Homo sapiens_hsa052190.48321163
135Pancreatic secretion_Homo sapiens_hsa049720.47376081
136Fatty acid biosynthesis_Homo sapiens_hsa000610.43367801
137mTOR signaling pathway_Homo sapiens_hsa041500.41230663
138Thyroid hormone signaling pathway_Homo sapiens_hsa049190.40368027
139AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.39041149
140Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.38699869
141Tight junction_Homo sapiens_hsa045300.38214540
142Chronic myeloid leukemia_Homo sapiens_hsa052200.38121609
143Longevity regulating pathway - mammal_Homo sapiens_hsa042110.38042314
144African trypanosomiasis_Homo sapiens_hsa051430.37240891
145Histidine metabolism_Homo sapiens_hsa003400.36642709
146Glycerophospholipid metabolism_Homo sapiens_hsa005640.34782879
147Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.33993596
148Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.33941650
149Lysosome_Homo sapiens_hsa041420.33048474

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