ING2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of the inhibitor of growth (ING) family. Members of the ING family associate with and modulate the activity of histone acetyltransferase (HAT) and histone deacetylase (HDAC) complexes and function in DNA repair and apoptosis. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1chaperone-mediated protein transport (GO:0072321)5.53746280
2maturation of SSU-rRNA (GO:0030490)5.06775854
3positive regulation of hematopoietic progenitor cell differentiation (GO:1901534)4.98939399
4presynaptic membrane assembly (GO:0097105)4.98606689
5pyrimidine deoxyribonucleotide catabolic process (GO:0009223)4.33124269
6presynaptic membrane organization (GO:0097090)4.28401646
7viral transcription (GO:0019083)4.27040750
8GTP biosynthetic process (GO:0006183)4.22092907
9SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.19784717
10cotranslational protein targeting to membrane (GO:0006613)4.18251570
11protein targeting to ER (GO:0045047)4.17082031
12protein complex biogenesis (GO:0070271)4.16395649
13translational termination (GO:0006415)4.14291380
14CENP-A containing nucleosome assembly (GO:0034080)4.07356546
15pyrimidine deoxyribonucleotide metabolic process (GO:0009219)4.04101162
16positive regulation of response to oxidative stress (GO:1902884)4.03810183
17positive regulation of cellular response to oxidative stress (GO:1900409)4.03810183
18chromatin remodeling at centromere (GO:0031055)4.03592376
19keratinocyte development (GO:0003334)4.02946470
20mitochondrial respiratory chain complex assembly (GO:0033108)3.99453282
21ribosomal small subunit biogenesis (GO:0042274)3.98845151
22establishment of protein localization to endoplasmic reticulum (GO:0072599)3.98721891
23DNA deamination (GO:0045006)3.95698726
24regulation of mitochondrial translation (GO:0070129)3.90784717
25protein neddylation (GO:0045116)3.89208982
26UTP biosynthetic process (GO:0006228)3.87130688
27kinetochore organization (GO:0051383)3.84777068
28protein localization to endoplasmic reticulum (GO:0070972)3.84243814
29pseudouridine synthesis (GO:0001522)3.82781663
30proteasome assembly (GO:0043248)3.78939266
31mitochondrial respiratory chain complex I assembly (GO:0032981)3.78016045
32NADH dehydrogenase complex assembly (GO:0010257)3.78016045
33mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.78016045
34protein-cofactor linkage (GO:0018065)3.69746250
35rRNA modification (GO:0000154)3.67427995
36protein maturation by protein folding (GO:0022417)3.65468568
37DNA replication checkpoint (GO:0000076)3.63845431
38mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.63346748
39negative regulation of retinoic acid receptor signaling pathway (GO:0048387)3.59689390
40ribonucleoprotein complex biogenesis (GO:0022613)3.57181624
41negative regulation of transcription by competitive promoter binding (GO:0010944)3.55019696
42kinetochore assembly (GO:0051382)3.51421799
43cellular component biogenesis (GO:0044085)3.50509394
44piRNA metabolic process (GO:0034587)3.49565271
45CTP metabolic process (GO:0046036)3.46954293
46CTP biosynthetic process (GO:0006241)3.46954293
47translational initiation (GO:0006413)3.46468336
48pyrimidine nucleotide catabolic process (GO:0006244)3.42551555
49translational elongation (GO:0006414)3.41979669
50histone exchange (GO:0043486)3.35086175
51spliceosomal complex assembly (GO:0000245)3.34028296
52UTP metabolic process (GO:0046051)3.30871141
53nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.30367281
54protein targeting to mitochondrion (GO:0006626)3.30224214
55cellular protein complex disassembly (GO:0043624)3.26629701
56pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)3.26324573
57guanosine-containing compound biosynthetic process (GO:1901070)3.22644722
58energy coupled proton transport, down electrochemical gradient (GO:0015985)3.20618178
59ATP synthesis coupled proton transport (GO:0015986)3.20618178
60DNA double-strand break processing (GO:0000729)3.19821938
61DNA replication-independent nucleosome assembly (GO:0006336)3.19334785
62DNA replication-independent nucleosome organization (GO:0034724)3.19334785
63ribosomal large subunit biogenesis (GO:0042273)3.19324236
64DNA strand elongation (GO:0022616)3.18603516
65tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.18138685
66RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.18138685
67establishment of protein localization to mitochondrion (GO:0072655)3.15915745
68positive regulation of mitochondrial fission (GO:0090141)3.15175050
69deoxyribonucleotide catabolic process (GO:0009264)3.13779807
70deoxyribose phosphate catabolic process (GO:0046386)3.11912112
71protein localization to mitochondrion (GO:0070585)3.09492487
72neuronal action potential propagation (GO:0019227)3.08711443
73DNA damage response, detection of DNA damage (GO:0042769)3.08197403
74water-soluble vitamin biosynthetic process (GO:0042364)3.08085006
75rRNA methylation (GO:0031167)3.07754626
76pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)3.07223579
77deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.06952953
78ribosomal small subunit assembly (GO:0000028)3.06586647
79regulation of axon regeneration (GO:0048679)3.04138519
80regulation of neuron projection regeneration (GO:0070570)3.04138519
81regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)3.03306929
82tRNA methylation (GO:0030488)3.02212190
83mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.01148087
84exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.01113889
85regulation of retinoic acid receptor signaling pathway (GO:0048385)3.01018467
86replication fork processing (GO:0031297)2.99412706
87pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.99241572
88regulation of DNA endoreduplication (GO:0032875)2.97921498
89postsynaptic membrane organization (GO:0001941)2.95716951
90respiratory chain complex IV assembly (GO:0008535)2.95391852
91viral life cycle (GO:0019058)2.94335104
92DNA replication initiation (GO:0006270)2.93785923
93establishment of protein localization to mitochondrial membrane (GO:0090151)2.92464864
94histone mRNA metabolic process (GO:0008334)2.91477279
95negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.90609694
96poly(A)+ mRNA export from nucleus (GO:0016973)2.90551200
97positive regulation of transcription elongation from RNA polymerase II promoter (GO:0032968)2.89322416
98epithelial cilium movement (GO:0003351)2.88652908
99nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.88192506
100telomere maintenance via telomere lengthening (GO:0010833)2.88039726
101pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)2.87930295
102protein complex disassembly (GO:0043241)2.87579702
103DNA catabolic process, exonucleolytic (GO:0000738)2.85725717
104organelle disassembly (GO:1903008)2.85092297
105macromolecular complex disassembly (GO:0032984)2.84021976
106translation (GO:0006412)2.83304018
1072-deoxyribonucleotide biosynthetic process (GO:0009265)2.83155078
108deoxyribose phosphate biosynthetic process (GO:0046385)2.83155078
109protein K6-linked ubiquitination (GO:0085020)2.82654841
110maturation of 5.8S rRNA (GO:0000460)2.82021387
111deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.81999082
112viral mRNA export from host cell nucleus (GO:0046784)2.81287673
113formation of translation preinitiation complex (GO:0001731)2.77145696
114somatic diversification of immune receptors via somatic mutation (GO:0002566)2.76905063
115somatic hypermutation of immunoglobulin genes (GO:0016446)2.76905063
116RNA catabolic process (GO:0006401)2.75673132
117nucleotide-excision repair, DNA gap filling (GO:0006297)2.75345667
118spliceosomal snRNP assembly (GO:0000387)2.74748424
119endocrine pancreas development (GO:0031018)2.74384280
120centriole replication (GO:0007099)2.73503130
121establishment of integrated proviral latency (GO:0075713)2.70196242
122nucleoside diphosphate phosphorylation (GO:0006165)2.69929529
123telomere maintenance via semi-conservative replication (GO:0032201)2.68351479
124regulation of ruffle assembly (GO:1900027)2.66300552
125regulation of oxidative phosphorylation (GO:0002082)2.66053762
126transcription elongation from RNA polymerase III promoter (GO:0006385)2.65521636
127termination of RNA polymerase III transcription (GO:0006386)2.65521636
128positive regulation of meiosis (GO:0045836)2.64682542
129regulation of actin nucleation (GO:0051125)2.64399081
130regulation of cilium movement (GO:0003352)2.63567976
131glandular epithelial cell differentiation (GO:0002067)2.61273553
132regulation of nuclear cell cycle DNA replication (GO:0033262)2.61076214
133positive regulation of megakaryocyte differentiation (GO:0045654)2.60408488
134negative regulation of DNA-dependent DNA replication (GO:2000104)2.60135316
135DNA strand elongation involved in DNA replication (GO:0006271)2.58843614
136nuclear-transcribed mRNA catabolic process (GO:0000956)2.56054826
137regulation of dopamine metabolic process (GO:0042053)2.55121391
138regulation of catecholamine metabolic process (GO:0042069)2.55121391
139rRNA processing (GO:0006364)2.54635111
140transcription elongation from RNA polymerase I promoter (GO:0006362)2.53347934
141mitotic recombination (GO:0006312)2.52580683
142protein targeting to membrane (GO:0006612)2.51553166
143respiratory electron transport chain (GO:0022904)2.51244782
144telomere maintenance via recombination (GO:0000722)2.50225417
145regulation of meiosis I (GO:0060631)2.49929981
146rRNA metabolic process (GO:0016072)2.49441008
147deoxyribonucleoside diphosphate metabolic process (GO:0009186)2.48035936
148centriole assembly (GO:0098534)2.47644367
149positive regulation of meiotic cell cycle (GO:0051446)2.47400894
150electron transport chain (GO:0022900)2.47096742
151negative regulation of Ras GTPase activity (GO:0034261)2.45094506
152pyrimidine nucleotide biosynthetic process (GO:0006221)2.44190919
153positive regulation of inositol phosphate biosynthetic process (GO:0060732)2.43158652
154cytochrome complex assembly (GO:0017004)2.42974483
155tRNA modification (GO:0006400)2.41892846
156mRNA catabolic process (GO:0006402)2.40770007
1577-methylguanosine RNA capping (GO:0009452)2.39511391

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.50586115
2FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.69024268
3SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.21215686
4MYC_18555785_ChIP-Seq_MESCs_Mouse3.41894788
5KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.29508798
6EST1_17652178_ChIP-ChIP_JURKAT_Human2.84197181
7* GABP_17652178_ChIP-ChIP_JURKAT_Human2.66376938
8JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.59477388
9E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.53973088
10ETS1_20019798_ChIP-Seq_JURKAT_Human2.49001375
11E2F4_17652178_ChIP-ChIP_JURKAT_Human2.41204986
12CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.30562542
13VDR_23849224_ChIP-Seq_CD4+_Human2.27670929
14RBPJ_22232070_ChIP-Seq_NCS_Mouse2.25196791
15HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.24976110
16MYC_19030024_ChIP-ChIP_MESCs_Mouse2.23798810
17MYC_19079543_ChIP-ChIP_MESCs_Mouse2.21888327
18ELF1_17652178_ChIP-ChIP_JURKAT_Human2.21667146
19MYC_18940864_ChIP-ChIP_HL60_Human2.20236370
20PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.19179880
21FUS_26573619_Chip-Seq_HEK293_Human2.18351603
22HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.12473707
23SRF_21415370_ChIP-Seq_HL-1_Mouse2.07689671
24FOXP3_21729870_ChIP-Seq_TREG_Human2.02817313
25E2F1_21310950_ChIP-Seq_MCF-7_Human1.99990066
26FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.96734553
27HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.96316206
28* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.90887015
29EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.86761257
30IRF1_19129219_ChIP-ChIP_H3396_Human1.86363016
31FOXM1_23109430_ChIP-Seq_U2OS_Human1.85662057
32VDR_22108803_ChIP-Seq_LS180_Human1.84729300
33MYC_18358816_ChIP-ChIP_MESCs_Mouse1.84248531
34* ELK1_19687146_ChIP-ChIP_HELA_Human1.83941921
35PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.78896007
36CREB1_15753290_ChIP-ChIP_HEK293T_Human1.75029058
37TTF2_22483619_ChIP-Seq_HELA_Human1.72057696
38KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.69734406
39KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.69734406
40KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.69734406
41CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.68064675
42FLI1_27457419_Chip-Seq_LIVER_Mouse1.65029323
43EZH2_22144423_ChIP-Seq_EOC_Human1.63628357
44HOXB4_20404135_ChIP-ChIP_EML_Mouse1.58166005
45NOTCH1_21737748_ChIP-Seq_TLL_Human1.52513380
46* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.52241633
47ZNF274_21170338_ChIP-Seq_K562_Hela1.52160546
48GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.50313708
49TAF15_26573619_Chip-Seq_HEK293_Human1.50266999
50FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.48858494
51MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.45132489
52MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.43144369
53MYCN_18555785_ChIP-Seq_MESCs_Mouse1.42512390
54PADI4_21655091_ChIP-ChIP_MCF-7_Human1.42487914
55GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.42009461
56POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.40901960
57POU3F2_20337985_ChIP-ChIP_501MEL_Human1.37177476
58XRN2_22483619_ChIP-Seq_HELA_Human1.35016485
59DCP1A_22483619_ChIP-Seq_HELA_Human1.32643509
60RNF2_27304074_Chip-Seq_NSC_Mouse1.31967851
61TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.31259826
62YY1_21170310_ChIP-Seq_MESCs_Mouse1.30744475
63THAP11_20581084_ChIP-Seq_MESCs_Mouse1.30219257
64* KDM5A_27292631_Chip-Seq_BREAST_Human1.28739634
65E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.28365197
66ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.26941277
67PCGF2_27294783_Chip-Seq_ESCs_Mouse1.26111206
68ZNF263_19887448_ChIP-Seq_K562_Human1.25397695
69POU5F1_16153702_ChIP-ChIP_HESCs_Human1.22179776
70* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.21630634
71DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.21262399
72E2F1_18555785_ChIP-Seq_MESCs_Mouse1.21071159
73CTBP1_25329375_ChIP-Seq_LNCAP_Human1.19722815
74MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.17769146
75SOX2_16153702_ChIP-ChIP_HESCs_Human1.16106918
76CIITA_25753668_ChIP-Seq_RAJI_Human1.15985428
77SOX2_18555785_ChIP-Seq_MESCs_Mouse1.15724262
78TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.13930991
79SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.11325885
80* SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.10381200
81CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.10233391
82ERG_20887958_ChIP-Seq_HPC-7_Mouse1.09194967
83* GABP_19822575_ChIP-Seq_HepG2_Human1.08947285
84SALL1_21062744_ChIP-ChIP_HESCs_Human1.08237194
85CTBP2_25329375_ChIP-Seq_LNCAP_Human1.05508443
86TP53_22573176_ChIP-Seq_HFKS_Human1.05311991
87NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.05127313
88YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.04141461
89* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.03218784
90NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.02343979
91GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.02238267
92CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.01590263
93TP63_19390658_ChIP-ChIP_HaCaT_Human1.01554469
94AR_21909140_ChIP-Seq_LNCAP_Human1.00886191
95SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.00659994
96JARID2_20064375_ChIP-Seq_MESCs_Mouse0.98529989
97CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.98451300
98* ELK1_22589737_ChIP-Seq_MCF10A_Human0.98433645
99NANOG_18555785_ChIP-Seq_MESCs_Mouse0.97042524
100ZFP57_27257070_Chip-Seq_ESCs_Mouse0.96383520
101NANOG_16153702_ChIP-ChIP_HESCs_Human0.96347937
102BMI1_23680149_ChIP-Seq_NPCS_Mouse0.95255983
103EWS_26573619_Chip-Seq_HEK293_Human0.95086216
104REST_21632747_ChIP-Seq_MESCs_Mouse0.94273711
105NFE2_27457419_Chip-Seq_LIVER_Mouse0.93452549
106SUZ12_27294783_Chip-Seq_NPCs_Mouse0.93411864
107PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.93160089
108SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.92803080
109POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.92653899
110TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.90623351
111SCL_19346495_ChIP-Seq_HPC-7_Human0.90612374
112PKCTHETA_26484144_Chip-Seq_BREAST_Human0.90587988
113ZFX_18555785_ChIP-Seq_MESCs_Mouse0.90002732
114ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.89702766
115EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.89618235
116AR_21572438_ChIP-Seq_LNCaP_Human0.88966118
117P53_22387025_ChIP-Seq_ESCs_Mouse0.88528033
118ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.88044581
119NANOG_18555785_Chip-Seq_ESCs_Mouse0.87488982
120BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.85539120
121FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.83098830
122HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.76858002
123KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.76381014
124EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.76359937
125TFEB_21752829_ChIP-Seq_HELA_Human0.72168694

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0006292_abnormal_olfactory_placode5.10049515
2MP0003880_abnormal_central_pattern4.01583003
3MP0002877_abnormal_melanocyte_morpholog3.62078280
4MP0009379_abnormal_foot_pigmentation3.19434615
5MP0006072_abnormal_retinal_apoptosis2.65753408
6MP0001188_hyperpigmentation2.27051056
7MP0003136_yellow_coat_color2.25880866
8MP0004957_abnormal_blastocyst_morpholog2.22938533
9MP0004043_abnormal_pH_regulation2.22851645
10MP0008877_abnormal_DNA_methylation2.22733334
11MP0004147_increased_porphyrin_level1.99259685
12MP0005171_absent_coat_pigmentation1.94012446
13MP0003183_abnormal_peptide_metabolism1.90946316
14MP0002693_abnormal_pancreas_physiology1.89698030
15MP0001944_abnormal_pancreas_morphology1.83202739
16MP0005379_endocrine/exocrine_gland_phen1.83103056
17MP0002009_preneoplasia1.81698833
18MP0006035_abnormal_mitochondrial_morpho1.77553004
19MP0010094_abnormal_chromosome_stability1.77312159
20MP0001485_abnormal_pinna_reflex1.73161407
21MP0002653_abnormal_ependyma_morphology1.71588682
22MP0005174_abnormal_tail_pigmentation1.71088801
23MP0003111_abnormal_nucleus_morphology1.67824364
24MP0003635_abnormal_synaptic_transmissio1.67629893
25MP0004264_abnormal_extraembryonic_tissu1.66026437
26MP0002277_abnormal_respiratory_mucosa1.65567070
27MP0003806_abnormal_nucleotide_metabolis1.65269231
28MP0000631_abnormal_neuroendocrine_gland1.64066652
29MP0002638_abnormal_pupillary_reflex1.61203132
30MP0003938_abnormal_ear_development1.60826908
31MP0003787_abnormal_imprinting1.60471334
32MP0010307_abnormal_tumor_latency1.59833697
33MP0000678_abnormal_parathyroid_gland1.57683640
34MP0003186_abnormal_redox_activity1.53836126
35MP0010386_abnormal_urinary_bladder1.53073836
36MP0009745_abnormal_behavioral_response1.52397540
37MP0002160_abnormal_reproductive_system1.50597594
38MP0008057_abnormal_DNA_replication1.48165316
39MP0005220_abnormal_exocrine_pancreas1.48053180
40MP0003567_abnormal_fetal_cardiomyocyte1.48009077
41MP0002102_abnormal_ear_morphology1.46300728
42MP0000015_abnormal_ear_pigmentation1.45682908
43MP0005389_reproductive_system_phenotype1.44504308
44MP0004142_abnormal_muscle_tone1.43550296
45MP0003123_paternal_imprinting1.38167307
46MP0001986_abnormal_taste_sensitivity1.35696009
47MP0008007_abnormal_cellular_replicative1.34563766
48MP0009780_abnormal_chondrocyte_physiolo1.30274652
49MP0003890_abnormal_embryonic-extraembry1.29848273
50MP0003868_abnormal_feces_composition1.28928003
51MP0003011_delayed_dark_adaptation1.28812117
52MP0000049_abnormal_middle_ear1.26449754
53MP0003646_muscle_fatigue1.24283376
54MP0002938_white_spotting1.24089978
55MP0002272_abnormal_nervous_system1.23824872
56MP0005253_abnormal_eye_physiology1.23456109
57MP0008058_abnormal_DNA_repair1.23187899
58MP0001501_abnormal_sleep_pattern1.22574620
59MP0002063_abnormal_learning/memory/cond1.21384627
60MP0002572_abnormal_emotion/affect_behav1.20599389
61MP0000613_abnormal_salivary_gland1.19577743
62MP0004270_analgesia1.18913145
63MP0002064_seizures1.18310092
64MP0002837_dystrophic_cardiac_calcinosis1.17563858
65MP0005084_abnormal_gallbladder_morpholo1.16212486
66MP0009697_abnormal_copulation1.13214655
67MP0002736_abnormal_nociception_after1.13013305
68MP0005646_abnormal_pituitary_gland1.12090997
69MP0004133_heterotaxia1.11493755
70MP0001486_abnormal_startle_reflex1.11182256
71MP0004859_abnormal_synaptic_plasticity1.08796748
72MP0002095_abnormal_skin_pigmentation1.08769240
73MP0001440_abnormal_grooming_behavior1.08546107
74MP0000350_abnormal_cell_proliferation1.08189105
75MP0001919_abnormal_reproductive_system1.06515259
76MP0002177_abnormal_outer_ear1.03178974
77MP0000313_abnormal_cell_death1.02711624
78MP0009384_cardiac_valve_regurgitation1.02563087
79MP0003786_premature_aging1.02439089
80MP0001529_abnormal_vocalization1.02406789
81MP0003077_abnormal_cell_cycle1.02230375
82MP0005408_hypopigmentation1.01838761
83MP0005257_abnormal_intraocular_pressure1.01446808
84MP0000358_abnormal_cell_content/0.99530449
85MP0001905_abnormal_dopamine_level0.98422574
86MP0003718_maternal_effect0.97733852
87MP0001929_abnormal_gametogenesis0.96941918
88MP0001968_abnormal_touch/_nociception0.94606340
89MP0003693_abnormal_embryo_hatching0.94390462
90MP0004145_abnormal_muscle_electrophysio0.92550166
91MP0004742_abnormal_vestibular_system0.92028853
92MP0008932_abnormal_embryonic_tissue0.90683935
93MP0003385_abnormal_body_wall0.89701933
94MP0006036_abnormal_mitochondrial_physio0.89577549
95MP0008789_abnormal_olfactory_epithelium0.89177016
96MP0001697_abnormal_embryo_size0.89006622
97MP0008995_early_reproductive_senescence0.88006693
98MP0005075_abnormal_melanosome_morpholog0.87646948
99MP0000013_abnormal_adipose_tissue0.87459816
100MP0000569_abnormal_digit_pigmentation0.87426312
101MP0002163_abnormal_gland_morphology0.87172162
102MP0001730_embryonic_growth_arrest0.86477883
103MP0002233_abnormal_nose_morphology0.86105226
104MP0002557_abnormal_social/conspecific_i0.85704655
105MP0002067_abnormal_sensory_capabilities0.85522184
106MP0000639_abnormal_adrenal_gland0.85063487
107MP0003937_abnormal_limbs/digits/tail_de0.84780736
108MP0005409_darkened_coat_color0.84753115
109MP0005645_abnormal_hypothalamus_physiol0.84460921
110MP0005248_abnormal_Harderian_gland0.82646023
111MP0000516_abnormal_urinary_system0.82619733
112MP0005367_renal/urinary_system_phenotyp0.82619733
113MP0006276_abnormal_autonomic_nervous0.82394143
114MP0001764_abnormal_homeostasis0.79635630
115MP0001727_abnormal_embryo_implantation0.78315334
116MP0005410_abnormal_fertilization0.78228447
117MP0001145_abnormal_male_reproductive0.78103269
118MP0005380_embryogenesis_phenotype0.78079840
119MP0001672_abnormal_embryogenesis/_devel0.78079840
120MP0003122_maternal_imprinting0.77971559
121MP0003119_abnormal_digestive_system0.77659095
122MP0001765_abnormal_ion_homeostasis0.76984742
123MP0002111_abnormal_tail_morphology0.76328991
124MP0002084_abnormal_developmental_patter0.76105685
125MP0001293_anophthalmia0.75487147
126MP0005310_abnormal_salivary_gland0.75202959
127MP0003936_abnormal_reproductive_system0.74392644
128MP0003984_embryonic_growth_retardation0.74326231
129MP0000653_abnormal_sex_gland0.73707487
130MP0005551_abnormal_eye_electrophysiolog0.73598652
131MP0001119_abnormal_female_reproductive0.73353006
132MP0001661_extended_life_span0.73009738
133MP0000427_abnormal_hair_cycle0.72715659
134MP0002085_abnormal_embryonic_tissue0.72414901
135MP0002088_abnormal_embryonic_growth/wei0.71895569
136MP0000372_irregular_coat_pigmentation0.71055242
137MP0002210_abnormal_sex_determination0.70930963
138MP0005391_vision/eye_phenotype0.70628971
139MP0003121_genomic_imprinting0.69888037
140MP0003943_abnormal_hepatobiliary_system0.65837214
141MP0003315_abnormal_perineum_morphology0.65493748
142MP0009046_muscle_twitch0.65475347
143MP0008004_abnormal_stomach_pH0.65023455
144MP0005394_taste/olfaction_phenotype0.64986633
145MP0005499_abnormal_olfactory_system0.64986633
146MP0001963_abnormal_hearing_physiology0.64692139
147MP0008872_abnormal_physiological_respon0.64608682
148MP0003698_abnormal_male_reproductive0.64468870
149MP0001881_abnormal_mammary_gland0.64271209
150MP0001286_abnormal_eye_development0.62570923
151MP0002080_prenatal_lethality0.60888669

Predicted human phenotypes

RankGene SetZ-score
1Aplastic anemia (HP:0001915)4.21635912
2Abnormality of cells of the erythroid lineage (HP:0012130)4.18127679
3Abnormal number of erythroid precursors (HP:0012131)4.10245995
4Abnormality of the labia minora (HP:0012880)4.03616573
5Septo-optic dysplasia (HP:0100842)3.41273698
6Reticulocytopenia (HP:0001896)3.37872343
7Macrocytic anemia (HP:0001972)3.32177632
8Focal motor seizures (HP:0011153)3.22412444
9Hepatic necrosis (HP:0002605)3.09792458
10Pallor (HP:0000980)3.07271473
11Short tibia (HP:0005736)3.02949129
12Hyperventilation (HP:0002883)3.01605886
13Abnormal respiratory motile cilium morphology (HP:0005938)2.90860890
14Abnormal respiratory epithelium morphology (HP:0012253)2.90860890
15Cerebral edema (HP:0002181)2.88248487
16Decreased activity of mitochondrial respiratory chain (HP:0008972)2.87624120
17Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.87624120
18Absent/shortened dynein arms (HP:0200106)2.82238748
19Dynein arm defect of respiratory motile cilia (HP:0012255)2.82238748
20Volvulus (HP:0002580)2.81238969
21Increased intramyocellular lipid droplets (HP:0012240)2.75731479
22Hyperglycinemia (HP:0002154)2.74601749
23Acute necrotizing encephalopathy (HP:0006965)2.73613624
24Increased hepatocellular lipid droplets (HP:0006565)2.72282891
25Aplasia/hypoplasia of the uterus (HP:0008684)2.65750672
26Visual hallucinations (HP:0002367)2.62257680
27Mitochondrial inheritance (HP:0001427)2.62024416
28Abnormal ciliary motility (HP:0012262)2.57569057
29Aplasia/Hypoplasia of the tibia (HP:0005772)2.57252544
30Chromsome breakage (HP:0040012)2.52408690
31Amblyopia (HP:0000646)2.50179214
323-Methylglutaconic aciduria (HP:0003535)2.49803350
33Hydroureter (HP:0000072)2.47673318
34True hermaphroditism (HP:0010459)2.47306995
35Progressive macrocephaly (HP:0004481)2.47297873
36Absent septum pellucidum (HP:0001331)2.47278598
37Abnormal hemoglobin (HP:0011902)2.45830514
38Conjugated hyperbilirubinemia (HP:0002908)2.43607718
39Respiratory failure (HP:0002878)2.41836037
40Split foot (HP:0001839)2.41431067
41Methylmalonic acidemia (HP:0002912)2.38276112
42Increased muscle lipid content (HP:0009058)2.37989002
43Birth length less than 3rd percentile (HP:0003561)2.37338311
44Methylmalonic aciduria (HP:0012120)2.36272763
45Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.34969410
46Colon cancer (HP:0003003)2.34547725
47Aplasia/Hypoplasia of the sacrum (HP:0008517)2.34270911
48Exercise intolerance (HP:0003546)2.33879819
49Epileptic encephalopathy (HP:0200134)2.33574398
50Chromosomal breakage induced by crosslinking agents (HP:0003221)2.32052897
51Increased serum lactate (HP:0002151)2.31708867
52Tubulointerstitial nephritis (HP:0001970)2.31675607
53Lactic acidosis (HP:0003128)2.29504903
54Exertional dyspnea (HP:0002875)2.27977136
55Abnormality of midbrain morphology (HP:0002418)2.26895901
56Molar tooth sign on MRI (HP:0002419)2.26895901
57Acute encephalopathy (HP:0006846)2.24220673
58Supernumerary spleens (HP:0009799)2.22569524
59Abnormal respiratory motile cilium physiology (HP:0012261)2.22258124
60Horseshoe kidney (HP:0000085)2.19514285
61Hyperinsulinemic hypoglycemia (HP:0000825)2.19114428
62Oral leukoplakia (HP:0002745)2.17219263
63Lipid accumulation in hepatocytes (HP:0006561)2.16766340
64Hyperphosphaturia (HP:0003109)2.15271676
65Protruding tongue (HP:0010808)2.14218407
66Duplication of thumb phalanx (HP:0009942)2.14029045
67Premature graying of hair (HP:0002216)2.10986748
68Atonic seizures (HP:0010819)2.07487337
69Abnormality of the septum pellucidum (HP:0007375)2.07414794
70Congenital sensorineural hearing impairment (HP:0008527)2.07316479
71Male pseudohermaphroditism (HP:0000037)2.06940682
72Decreased circulating renin level (HP:0003351)2.05925307
73Increased CSF lactate (HP:0002490)2.05355513
74Lethargy (HP:0001254)2.04753371
75Cleft eyelid (HP:0000625)2.04664202
76Aplasia/Hypoplasia of the uvula (HP:0010293)2.03738274
77Intestinal atresia (HP:0011100)2.02595633
78Popliteal pterygium (HP:0009756)2.02509735
79Abnormal lung lobation (HP:0002101)2.02034345
80White forelock (HP:0002211)2.01905973
81Renal Fanconi syndrome (HP:0001994)2.00441209
82Bilateral microphthalmos (HP:0007633)2.00017373
83Abnormality of the metopic suture (HP:0005556)1.99547355
84Pancreatic fibrosis (HP:0100732)1.99465630
85Abnormality of the phalanges of the hallux (HP:0010057)1.98341098
86Meckel diverticulum (HP:0002245)1.97575588
87Triphalangeal thumb (HP:0001199)1.97526672
88Abnormal mitochondria in muscle tissue (HP:0008316)1.97432948
89Abnormal number of incisors (HP:0011064)1.96114585
90Stenosis of the external auditory canal (HP:0000402)1.95949384
91Nephronophthisis (HP:0000090)1.95774993
92Facial hemangioma (HP:0000329)1.94688033
93Absent speech (HP:0001344)1.93086103
94Nephrogenic diabetes insipidus (HP:0009806)1.92359020
95Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.90683219
96Symptomatic seizures (HP:0011145)1.90611635
97Abnormality of dental color (HP:0011073)1.89206170
98Abnormality of the ileum (HP:0001549)1.87285437
99Elevated erythrocyte sedimentation rate (HP:0003565)1.86837173
100Limb dystonia (HP:0002451)1.85734470
101Spastic paraparesis (HP:0002313)1.85230973
102Absent thumb (HP:0009777)1.85105120
103Rib fusion (HP:0000902)1.84001690
104Multiple enchondromatosis (HP:0005701)1.83437849
105Hepatocellular necrosis (HP:0001404)1.83032207
106Abnormal urine phosphate concentration (HP:0012599)1.82327090
107Chronic bronchitis (HP:0004469)1.81380690
108Abnormality of lateral ventricle (HP:0030047)1.80502048
109Gastrointestinal atresia (HP:0002589)1.80293736
110Patchy hypopigmentation of hair (HP:0011365)1.79654086
111Respiratory difficulties (HP:0002880)1.79541178
112Abnormal sex determination (HP:0012244)1.78990170
113Sex reversal (HP:0012245)1.78990170
114Hypoglycemic coma (HP:0001325)1.78685810
115Median cleft lip (HP:0000161)1.78538634
116Optic disc pallor (HP:0000543)1.78065703
117Maternal diabetes (HP:0009800)1.77919452
118Hypoplastic pelvis (HP:0008839)1.77901717
119Hypoplasia of the fovea (HP:0007750)1.77847578
120Aplasia/Hypoplasia of the fovea (HP:0008060)1.77847578
121Chronic sinusitis (HP:0011109)1.77557174
122Microvesicular hepatic steatosis (HP:0001414)1.76608623
123Aplasia involving forearm bones (HP:0009822)1.76570172
124Absent forearm bone (HP:0003953)1.76570172
125Hypoplasia of the radius (HP:0002984)1.76186687
126Fibular aplasia (HP:0002990)1.76158080
127Broad-based gait (HP:0002136)1.75999549
128Abnormality of dicarboxylic acid metabolism (HP:0010995)1.74418656
129Dicarboxylic aciduria (HP:0003215)1.74418656
130Leukodystrophy (HP:0002415)1.74367213
131Congenital primary aphakia (HP:0007707)1.73629875
132Prominent metopic ridge (HP:0005487)1.73394745
133Abnormal pancreas size (HP:0012094)1.71723511
134Sclerocornea (HP:0000647)1.70720224
135Hypoplastic iliac wings (HP:0002866)1.70375396
136Abnormality of the phalanges of the 2nd finger (HP:0009541)1.70174584
137Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.69756601
138Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.69456973
139Obstructive sleep apnea (HP:0002870)1.68155520
140Absence seizures (HP:0002121)1.67388171
141Pancreatic cysts (HP:0001737)1.67282997
142Abnormality of urine glucose concentration (HP:0011016)1.67078376
143Glycosuria (HP:0003076)1.67078376
144Dysautonomia (HP:0002459)1.66887058
145Dyschromatopsia (HP:0007641)1.65820238
146Cerebral hypomyelination (HP:0006808)1.64400623
147Absent radius (HP:0003974)1.63855473
148Adrenal hypoplasia (HP:0000835)1.63184062
149Medulloblastoma (HP:0002885)1.63177971
150CNS demyelination (HP:0007305)1.62920897
151Hypoglycemic seizures (HP:0002173)1.62681402
152Carpal bone hypoplasia (HP:0001498)1.62350083
153Abnormality of the heme biosynthetic pathway (HP:0010472)1.61878332
154Abnormality of the preputium (HP:0100587)1.61448629
155Duplicated collecting system (HP:0000081)1.61257044
156Medial flaring of the eyebrow (HP:0010747)1.61079937
157Progressive muscle weakness (HP:0003323)1.60313922
158Prolonged neonatal jaundice (HP:0006579)1.59644968
159Hypoplasia of the uterus (HP:0000013)1.59027117
160Hyperthyroidism (HP:0000836)1.58626757
161Pancytopenia (HP:0001876)1.57731226
162Abnormality of renal resorption (HP:0011038)1.57724656

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PNCK4.59589174
2NME13.15092275
3RIPK43.08194723
4MKNK23.07668142
5CDK192.87170696
6SRPK12.38652537
7MST42.38618796
8BMPR22.34846582
9VRK22.32069485
10CASK2.28366295
11EPHA42.21607823
12BCKDK2.17856576
13CDC72.14874335
14TLK12.14003134
15NUAK12.13049369
16IRAK42.10652628
17NTRK31.97440242
18TRIM281.92172663
19MAP3K21.91986721
20STK161.84726147
21PBK1.84395329
22WEE11.76679647
23SCYL21.76251334
24MAPK151.76070516
25GRK61.71520784
26BLK1.70657500
27NLK1.63563483
28NME21.62275442
29NEK11.62205250
30HIPK21.54685248
31CCNB11.49969912
32VRK11.47390951
33TESK21.46762634
34FES1.39483157
35BMPR1B1.38696294
36MAP2K71.35338918
37TNIK1.34051668
38PASK1.32686873
39TAOK31.32484842
40EIF2AK31.30949498
41MKNK11.28483486
42DYRK21.27603454
43MAP3K61.24454801
44PLK21.24380460
45UHMK11.21716337
46RAF11.17832519
47EIF2AK11.17412234
48PINK11.14927838
49PDK21.14591102
50PIM21.09142659
51INSRR1.08936890
52DAPK21.08508832
53KSR11.07661401
54KSR21.06409020
55NEK21.05190553
56BRSK21.03253289
57OXSR11.02903263
58CSNK1G30.98890675
59SIK20.97932269
60TYRO30.95947807
61DYRK30.95846967
62IRAK10.94320837
63ATR0.93506818
64PIM10.93167836
65MAP2K20.92415773
66STK110.92175642
67RPS6KA40.91470363
68CSNK1G20.88541972
69DAPK10.87215428
70FRK0.85493297
71FGR0.84830727
72ZAK0.84587853
73LIMK10.83850368
74CHEK20.83053355
75CAMK2B0.80290040
76ABL20.79931130
77TTK0.79340159
78MAP4K20.78977557
79MAP3K130.76647126
80CDK30.76132573
81BUB10.75426941
82TSSK60.74265886
83RPS6KA50.73887378
84CLK10.73625395
85MAP3K110.73221473
86CSNK2A20.71969337
87PRKCI0.69356872
88GRK50.69026440
89IRAK20.67985877
90PLK30.67747766
91DYRK1A0.67350292
92DMPK0.67193824
93STK390.66100053
94PLK10.65394202
95WNK40.65305506
96WNK30.64984723
97TAOK20.63078984
98PRKD20.60005511
99BRAF0.58954714
100FLT30.57909479
101ARAF0.56291812
102PRKCG0.55382914
103AURKA0.55029494
104CSNK1E0.54469305
105PRPF4B0.54413284
106MATK0.54082203
107MAP3K10.52146371
108MAP2K40.51732029
109CAMK2A0.51708244
110CDK70.51385817
111STK38L0.50922794
112PAK10.50545431
113MARK30.49524339
114MELK0.48918336
115CSNK2A10.47963941
116BRSK10.46719708
117ADRBK20.44740946
118PLK40.44025609
119CSNK1A1L0.43523369
120KDR0.41372261
121ATM0.40409307
122GRK10.39962213
123PRKDC0.39172866
124TESK10.38797710
125CAMKK20.38554471
126CDK20.38063944
127CDK40.37955639
128IKBKB0.37339472
129CDK10.37218256
130STK40.36232601
131MINK10.36070869
132ILK0.35480617
133CSNK1A10.33734127
134CHEK10.32823241
135MAP3K120.32733324
136SYK0.32489903
137MAP2K60.32284771
138CSNK1G10.32237824
139MAP3K40.31317101
140AURKB0.31072077
141MAP3K90.30541302
142PRKACA0.30090390
143ACVR1B0.28947715
144PAK60.28014085
145CDK50.27418897
146TEC0.27370270

Predicted pathways (KEGG)

RankGene SetZ-score
1Protein export_Homo sapiens_hsa030603.80879151
2Maturity onset diabetes of the young_Homo sapiens_hsa049503.77690693
3Ribosome_Homo sapiens_hsa030103.60651562
4RNA polymerase_Homo sapiens_hsa030202.67041581
5DNA replication_Homo sapiens_hsa030302.54577956
6Homologous recombination_Homo sapiens_hsa034402.34545228
7Basal transcription factors_Homo sapiens_hsa030222.31566723
8Oxidative phosphorylation_Homo sapiens_hsa001902.23559395
9Long-term potentiation_Homo sapiens_hsa047202.18165480
10Spliceosome_Homo sapiens_hsa030402.12052321
11Mismatch repair_Homo sapiens_hsa034302.09146945
12Amphetamine addiction_Homo sapiens_hsa050311.94002106
13Alzheimers disease_Homo sapiens_hsa050101.81149932
14Nucleotide excision repair_Homo sapiens_hsa034201.75107859
15Fanconi anemia pathway_Homo sapiens_hsa034601.69538554
16Parkinsons disease_Homo sapiens_hsa050121.68383929
17Nicotine addiction_Homo sapiens_hsa050331.63840400
18Proteasome_Homo sapiens_hsa030501.59840806
19Pyrimidine metabolism_Homo sapiens_hsa002401.58853306
20Huntingtons disease_Homo sapiens_hsa050161.58385452
21Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.58066963
22RNA transport_Homo sapiens_hsa030131.57444164
23Fatty acid elongation_Homo sapiens_hsa000621.56269693
24Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.52797729
25Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.48207559
26Insulin secretion_Homo sapiens_hsa049111.42915966
27RNA degradation_Homo sapiens_hsa030181.40130843
28Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.36596250
29Serotonergic synapse_Homo sapiens_hsa047261.36185271
30Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.33187815
31Non-homologous end-joining_Homo sapiens_hsa034501.30347367
32Long-term depression_Homo sapiens_hsa047301.29109743
33Dopaminergic synapse_Homo sapiens_hsa047281.25491788
34Base excision repair_Homo sapiens_hsa034101.24617635
35Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.24072838
36Renin secretion_Homo sapiens_hsa049241.20265019
37Steroid biosynthesis_Homo sapiens_hsa001001.18474322
38Circadian rhythm_Homo sapiens_hsa047101.17533329
39Phototransduction_Homo sapiens_hsa047441.16105030
40Glutamatergic synapse_Homo sapiens_hsa047241.14854060
41Sulfur relay system_Homo sapiens_hsa041221.11295381
42Taste transduction_Homo sapiens_hsa047421.07170990
43Selenocompound metabolism_Homo sapiens_hsa004501.05982451
44Glutathione metabolism_Homo sapiens_hsa004801.05711879
45Pancreatic secretion_Homo sapiens_hsa049721.01439335
46Circadian entrainment_Homo sapiens_hsa047131.01096266
47Butanoate metabolism_Homo sapiens_hsa006501.00436396
48Purine metabolism_Homo sapiens_hsa002300.99819217
49p53 signaling pathway_Homo sapiens_hsa041150.98967329
50Morphine addiction_Homo sapiens_hsa050320.98558035
51Thyroid cancer_Homo sapiens_hsa052160.98373335
52Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.97723151
53Oocyte meiosis_Homo sapiens_hsa041140.96930382
54Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.96883049
55Cysteine and methionine metabolism_Homo sapiens_hsa002700.96720363
56Propanoate metabolism_Homo sapiens_hsa006400.94595597
57SNARE interactions in vesicular transport_Homo sapiens_hsa041300.94439434
58Salivary secretion_Homo sapiens_hsa049700.86929811
59Vibrio cholerae infection_Homo sapiens_hsa051100.85611704
60Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.84947863
61GABAergic synapse_Homo sapiens_hsa047270.84666392
62Folate biosynthesis_Homo sapiens_hsa007900.82982136
63Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.82234971
64Cardiac muscle contraction_Homo sapiens_hsa042600.82183538
65Oxytocin signaling pathway_Homo sapiens_hsa049210.80584810
66Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.79704112
67Cell cycle_Homo sapiens_hsa041100.79655384
68Pyruvate metabolism_Homo sapiens_hsa006200.77858340
69Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.77107900
70Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.75845253
71Cholinergic synapse_Homo sapiens_hsa047250.74262817
72Metabolic pathways_Homo sapiens_hsa011000.73928560
73Cocaine addiction_Homo sapiens_hsa050300.72544340
74Sulfur metabolism_Homo sapiens_hsa009200.71659589
75Cyanoamino acid metabolism_Homo sapiens_hsa004600.71608027
76Ether lipid metabolism_Homo sapiens_hsa005650.71334785
77Melanogenesis_Homo sapiens_hsa049160.70606966
78GnRH signaling pathway_Homo sapiens_hsa049120.68730105
79Linoleic acid metabolism_Homo sapiens_hsa005910.65071866
80Estrogen signaling pathway_Homo sapiens_hsa049150.63950336
81mRNA surveillance pathway_Homo sapiens_hsa030150.63545764
82Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.61421637
83Drug metabolism - other enzymes_Homo sapiens_hsa009830.60846116
84Wnt signaling pathway_Homo sapiens_hsa043100.59600931
85Peroxisome_Homo sapiens_hsa041460.58657714
86Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.57745993
87Collecting duct acid secretion_Homo sapiens_hsa049660.57590081
88Glucagon signaling pathway_Homo sapiens_hsa049220.57093891
89Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.56873658
90Arachidonic acid metabolism_Homo sapiens_hsa005900.56320849
91Calcium signaling pathway_Homo sapiens_hsa040200.56077807
92VEGF signaling pathway_Homo sapiens_hsa043700.56070062
93cAMP signaling pathway_Homo sapiens_hsa040240.56008109
94Gap junction_Homo sapiens_hsa045400.54351080
95Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.53603675
96Aldosterone synthesis and secretion_Homo sapiens_hsa049250.53349846
97Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.51807687
98Alcoholism_Homo sapiens_hsa050340.51759626
99Vascular smooth muscle contraction_Homo sapiens_hsa042700.50932472
100Gastric acid secretion_Homo sapiens_hsa049710.50230307
101cGMP-PKG signaling pathway_Homo sapiens_hsa040220.49569357
102Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.48834572
103Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.47802604
104Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.45901342
105Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.44816215
106Dorso-ventral axis formation_Homo sapiens_hsa043200.42729380
107Prostate cancer_Homo sapiens_hsa052150.41094197
108Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.41034882
109Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.39939604
110Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.39257599
111Fatty acid metabolism_Homo sapiens_hsa012120.39049202
112Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.38844410
113Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.38585032
114Sphingolipid metabolism_Homo sapiens_hsa006000.38523526
115MAPK signaling pathway_Homo sapiens_hsa040100.36151752
116African trypanosomiasis_Homo sapiens_hsa051430.34894699
117Phosphatidylinositol signaling system_Homo sapiens_hsa040700.34800684
118One carbon pool by folate_Homo sapiens_hsa006700.34708014
119Chemical carcinogenesis_Homo sapiens_hsa052040.34484210
120Fatty acid degradation_Homo sapiens_hsa000710.33843699
121alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.33843573
122Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.33840443
123Regulation of autophagy_Homo sapiens_hsa041400.33258014
124Choline metabolism in cancer_Homo sapiens_hsa052310.33119810
125Vitamin digestion and absorption_Homo sapiens_hsa049770.32482160
126T cell receptor signaling pathway_Homo sapiens_hsa046600.32016155
127Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.31981204
128Sphingolipid signaling pathway_Homo sapiens_hsa040710.31085290
129Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.30021763
130TGF-beta signaling pathway_Homo sapiens_hsa043500.29655476
131beta-Alanine metabolism_Homo sapiens_hsa004100.29091269
132Carbohydrate digestion and absorption_Homo sapiens_hsa049730.28441866
133Transcriptional misregulation in cancer_Homo sapiens_hsa052020.28271546
134Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.28069662
135Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.27776393
136Hedgehog signaling pathway_Homo sapiens_hsa043400.25117975
137Basal cell carcinoma_Homo sapiens_hsa052170.23864399
138Fat digestion and absorption_Homo sapiens_hsa049750.19771179
139Primary immunodeficiency_Homo sapiens_hsa053400.19142492
140Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.18931893
141Pentose and glucuronate interconversions_Homo sapiens_hsa000400.18405304
142Retinol metabolism_Homo sapiens_hsa008300.14417199
143Tryptophan metabolism_Homo sapiens_hsa003800.13383868
144Steroid hormone biosynthesis_Homo sapiens_hsa001400.12447615
145Mineral absorption_Homo sapiens_hsa049780.12270324
146Hippo signaling pathway_Homo sapiens_hsa043900.12213408
147Epstein-Barr virus infection_Homo sapiens_hsa051690.11643606
148Carbon metabolism_Homo sapiens_hsa012000.11606192
149Legionellosis_Homo sapiens_hsa051340.11413759
150Galactose metabolism_Homo sapiens_hsa000520.10712568
151Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.09274403
152Rheumatoid arthritis_Homo sapiens_hsa053230.09084327
153Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.07771477
154Olfactory transduction_Homo sapiens_hsa047400.06446750
155Nitrogen metabolism_Homo sapiens_hsa009100.06281149

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