ING3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is similar to ING1, a tumor suppressor protein that can interact with TP53, inhibit cell growth, and induce apoptosis. This protein contains a PHD-finger, which is a common motif in proteins involved in chromatin remodeling. This gene can activate p53 trans-activated promoters, including promoters of p21/waf1 and bax. Overexpression of this gene has been shown to inhibit cell growth and induce apoptosis. Allelic loss and reduced expression of this gene were detected in head and neck cancers. Two alternatively spliced transcript variants encoding different isoforms have been observed. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA double-strand break processing (GO:0000729)4.77134682
2synapsis (GO:0007129)4.55248747
3proteasome assembly (GO:0043248)4.12513533
4response to pheromone (GO:0019236)3.81633417
5centriole replication (GO:0007099)3.81298226
6CENP-A containing nucleosome assembly (GO:0034080)3.81102331
7regulation of nuclear cell cycle DNA replication (GO:0033262)3.77709123
8regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.58839764
9regulation of mitotic spindle checkpoint (GO:1903504)3.58839764
10chromatin remodeling at centromere (GO:0031055)3.58392121
11DNA ligation (GO:0006266)3.56923116
12protein neddylation (GO:0045116)3.51093311
13ribosomal small subunit assembly (GO:0000028)3.48904010
14telomere maintenance via semi-conservative replication (GO:0032201)3.46098481
15viral mRNA export from host cell nucleus (GO:0046784)3.43693760
16transcription elongation from RNA polymerase III promoter (GO:0006385)3.43572576
17termination of RNA polymerase III transcription (GO:0006386)3.43572576
18respiratory chain complex IV assembly (GO:0008535)3.41856994
19deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.40808362
20kinetochore organization (GO:0051383)3.40707106
21prenylation (GO:0097354)3.40689553
22protein prenylation (GO:0018342)3.40689553
23DNA replication-independent nucleosome organization (GO:0034724)3.39144683
24DNA replication-independent nucleosome assembly (GO:0006336)3.39144683
25regulation of DNA endoreduplication (GO:0032875)3.33844874
26recombinational repair (GO:0000725)3.31665002
27double-strand break repair via homologous recombination (GO:0000724)3.30591364
28platelet dense granule organization (GO:0060155)3.30100918
29water-soluble vitamin biosynthetic process (GO:0042364)3.25841584
30telomere maintenance via recombination (GO:0000722)3.25559039
31meiotic chromosome segregation (GO:0045132)3.25257617
32attachment of spindle microtubules to kinetochore (GO:0008608)3.22915984
33DNA strand elongation involved in DNA replication (GO:0006271)3.16671528
34somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)3.16162163
35somatic diversification of immunoglobulins involved in immune response (GO:0002208)3.16162163
36isotype switching (GO:0045190)3.16162163
37piRNA metabolic process (GO:0034587)3.14066019
38somatic hypermutation of immunoglobulin genes (GO:0016446)3.09349363
39somatic diversification of immune receptors via somatic mutation (GO:0002566)3.09349363
40DNA replication-dependent nucleosome assembly (GO:0006335)3.08487051
41DNA replication-dependent nucleosome organization (GO:0034723)3.08487051
42DNA strand elongation (GO:0022616)3.08414128
43replication fork processing (GO:0031297)3.08063754
44regulation of centriole replication (GO:0046599)3.06575633
45rRNA methylation (GO:0031167)3.06570098
46maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.04812362
47cytochrome complex assembly (GO:0017004)3.03183813
48DNA replication initiation (GO:0006270)3.02205069
49DNA topological change (GO:0006265)3.01304697
50mitochondrial DNA replication (GO:0006264)3.00153956
51exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.98994269
52kinetochore assembly (GO:0051382)2.98917675
53protein complex biogenesis (GO:0070271)2.98722770
54mitotic recombination (GO:0006312)2.97985940
55positive regulation of mitotic sister chromatid separation (GO:1901970)2.97914308
56positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.97914308
57positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.97914308
58rRNA modification (GO:0000154)2.97872207
59telomere maintenance via telomere lengthening (GO:0010833)2.96500972
60nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.94336852
61definitive hemopoiesis (GO:0060216)2.91695313
62histone exchange (GO:0043486)2.91680451
63tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.89443616
64RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.89443616
65positive regulation of histone H3-K4 methylation (GO:0051571)2.89205646
66transcription-coupled nucleotide-excision repair (GO:0006283)2.88525709
67DNA-dependent DNA replication (GO:0006261)2.87842379
687-methylguanosine mRNA capping (GO:0006370)2.85683775
69lactate metabolic process (GO:0006089)2.84497527
70intra-S DNA damage checkpoint (GO:0031573)2.83942460
71mitochondrial respiratory chain complex assembly (GO:0033108)2.83402625
72RNA capping (GO:0036260)2.83218564
737-methylguanosine RNA capping (GO:0009452)2.83218564
74protein-cofactor linkage (GO:0018065)2.82947456
75DNA replication checkpoint (GO:0000076)2.81717404
76postreplication repair (GO:0006301)2.80351098
77mitotic G2/M transition checkpoint (GO:0044818)2.80048560
78termination of RNA polymerase I transcription (GO:0006363)2.79759538
79telomere maintenance (GO:0000723)2.79607139
80DNA deamination (GO:0045006)2.77674340
81establishment of protein localization to mitochondrial membrane (GO:0090151)2.77019421
82maturation of 5.8S rRNA (GO:0000460)2.76379890
83transcription elongation from RNA polymerase I promoter (GO:0006362)2.76147834
84telomere organization (GO:0032200)2.76091038
85spindle checkpoint (GO:0031577)2.75782587
86nucleotide-excision repair, DNA gap filling (GO:0006297)2.75667835
87RNA-dependent DNA replication (GO:0006278)2.75251423
88protein K11-linked deubiquitination (GO:0035871)2.72605274
89natural killer cell activation involved in immune response (GO:0002323)2.71895085
90preassembly of GPI anchor in ER membrane (GO:0016254)2.70221684
91mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.70109690
92mitochondrial respiratory chain complex I assembly (GO:0032981)2.70109690
93NADH dehydrogenase complex assembly (GO:0010257)2.70109690
94establishment of chromosome localization (GO:0051303)2.69572997
95regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.68284519
96negative regulation of telomere maintenance (GO:0032205)2.67579346
97negative regulation of DNA-dependent DNA replication (GO:2000104)2.67574741
98regulation of telomere maintenance (GO:0032204)2.66188591
99L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.65998325
100spliceosomal complex assembly (GO:0000245)2.65768853
101establishment of integrated proviral latency (GO:0075713)2.65646175
102protein deneddylation (GO:0000338)2.64843056
103regulation of double-strand break repair via homologous recombination (GO:0010569)2.64417273
104retinal cone cell development (GO:0046549)2.63974274
105ribosome biogenesis (GO:0042254)2.62372342
106poly(A)+ mRNA export from nucleus (GO:0016973)2.62232750
107mismatch repair (GO:0006298)2.61638653
108reciprocal meiotic recombination (GO:0007131)2.61607526
109reciprocal DNA recombination (GO:0035825)2.61607526
110double-strand break repair (GO:0006302)2.61311159
111protein K6-linked ubiquitination (GO:0085020)2.60899192
112negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.60787018
113mitotic spindle checkpoint (GO:0071174)2.60534708
114protein localization to kinetochore (GO:0034501)2.59991047
115male meiosis I (GO:0007141)2.59649473
116regulation of meiosis I (GO:0060631)2.59361326
117mitotic sister chromatid cohesion (GO:0007064)2.58979512
118meiotic cell cycle (GO:0051321)2.58806413
119intraciliary transport (GO:0042073)2.58298371
120telomere maintenance via telomerase (GO:0007004)2.57963210
121V(D)J recombination (GO:0033151)2.57826954
122histone mRNA metabolic process (GO:0008334)2.57696865
123anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.57530431
124regulation of mitotic metaphase/anaphase transition (GO:0030071)2.57219021
125regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.57219021
126positive regulation of hematopoietic progenitor cell differentiation (GO:1901534)2.56898698
127DNA catabolic process, exonucleolytic (GO:0000738)2.56498525
128positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.56213577
129fucose catabolic process (GO:0019317)2.56123635
130L-fucose metabolic process (GO:0042354)2.56123635
131L-fucose catabolic process (GO:0042355)2.56123635
132transcription from RNA polymerase I promoter (GO:0006360)2.54420839
133microtubule depolymerization (GO:0007019)2.53221566
134pseudouridine synthesis (GO:0001522)2.53088322
135regulation of mitotic sister chromatid segregation (GO:0033047)2.52857966
136mitotic metaphase plate congression (GO:0007080)2.52764911
137resolution of meiotic recombination intermediates (GO:0000712)2.52206555
138metaphase plate congression (GO:0051310)2.51938172
139DNA-templated transcription, termination (GO:0006353)2.50919505
140intracellular transport of virus (GO:0075733)2.49502917
141multi-organism transport (GO:0044766)2.49502917
142multi-organism localization (GO:1902579)2.49502917
143multi-organism intracellular transport (GO:1902583)2.49502917
144transport of virus (GO:0046794)2.49502917
145regulation of spindle checkpoint (GO:0090231)2.49440909
146nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:0000288)2.49126462
147DNA-templated transcription, elongation (GO:0006354)2.48855924
148nucleobase biosynthetic process (GO:0046112)2.48054656
149RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.47261510
150IMP metabolic process (GO:0046040)2.47042925
151transcription elongation from RNA polymerase II promoter (GO:0006368)2.46937416
152DNA replication (GO:0006260)2.46779136
153cullin deneddylation (GO:0010388)2.46090783
154monoubiquitinated protein deubiquitination (GO:0035520)2.46001917
155snRNA processing (GO:0016180)2.45260204
156transcription initiation from RNA polymerase I promoter (GO:0006361)2.45159324
157DNA synthesis involved in DNA repair (GO:0000731)2.45085307
158rRNA processing (GO:0006364)2.44929312
159positive regulation of megakaryocyte differentiation (GO:0045654)2.43699952
160mitotic sister chromatid segregation (GO:0000070)2.42935931

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.66288196
2* E2F4_17652178_ChIP-ChIP_JURKAT_Human3.48612456
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.28644801
4* EST1_17652178_ChIP-ChIP_JURKAT_Human3.08314181
5GABP_17652178_ChIP-ChIP_JURKAT_Human3.03473514
6HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.98861122
7* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.98172620
8* MYC_18555785_ChIP-Seq_MESCs_Mouse2.86276505
9ZNF274_21170338_ChIP-Seq_K562_Hela2.77828785
10FOXM1_23109430_ChIP-Seq_U2OS_Human2.68018414
11ELF1_17652178_ChIP-ChIP_JURKAT_Human2.64101830
12MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.54987376
13* VDR_23849224_ChIP-Seq_CD4+_Human2.49288258
14VDR_22108803_ChIP-Seq_LS180_Human2.47910146
15SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.45438522
16FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.43910441
17* HOXB4_20404135_ChIP-ChIP_EML_Mouse2.33738002
18* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.32795046
19JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.30371690
20ELK1_19687146_ChIP-ChIP_HELA_Human2.26697467
21CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.25390976
22IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.24985168
23NOTCH1_21737748_ChIP-Seq_TLL_Human2.24352004
24* NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.21983521
25ZFP57_27257070_Chip-Seq_ESCs_Mouse2.20359787
26FOXP3_21729870_ChIP-Seq_TREG_Human2.17593181
27TAF15_26573619_Chip-Seq_HEK293_Human2.09643524
28IGF1R_20145208_ChIP-Seq_DFB_Human2.07585881
29* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.03971306
30* HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.03268334
31SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.02030558
32* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse2.01223408
33SRF_21415370_ChIP-Seq_HL-1_Mouse2.00772040
34CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.95320174
35YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.94972518
36PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.94709394
37MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.93427600
38GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.93238409
39* CREB1_15753290_ChIP-ChIP_HEK293T_Human1.93051279
40GBX2_23144817_ChIP-Seq_PC3_Human1.92468940
41P300_19829295_ChIP-Seq_ESCs_Human1.88335299
42TP63_19390658_ChIP-ChIP_HaCaT_Human1.85498495
43* ETS1_20019798_ChIP-Seq_JURKAT_Human1.82541101
44MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.82332831
45KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.79280556
46MYC_18358816_ChIP-ChIP_MESCs_Mouse1.79065672
47SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.73731493
48CTBP2_25329375_ChIP-Seq_LNCAP_Human1.69726027
49IRF1_19129219_ChIP-ChIP_H3396_Human1.69575655
50NELFA_20434984_ChIP-Seq_ESCs_Mouse1.68812253
51CIITA_25753668_ChIP-Seq_RAJI_Human1.68323376
52FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.66776427
53DCP1A_22483619_ChIP-Seq_HELA_Human1.61110025
54* E2F1_21310950_ChIP-Seq_MCF-7_Human1.61074037
55STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.58782150
56MYC_19079543_ChIP-ChIP_MESCs_Mouse1.57874647
57EZH2_27294783_Chip-Seq_NPCs_Mouse1.55596866
58GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.54205527
59EWS_26573619_Chip-Seq_HEK293_Human1.53674316
60ER_23166858_ChIP-Seq_MCF-7_Human1.53167423
61CTBP1_25329375_ChIP-Seq_LNCAP_Human1.52864318
62AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.51197050
63FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.49488024
64* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.49189010
65E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.47808318
66TTF2_22483619_ChIP-Seq_HELA_Human1.44067334
67SUZ12_27294783_Chip-Seq_NPCs_Mouse1.43514256
68ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.42864457
69BCAT_22108803_ChIP-Seq_LS180_Human1.42330113
70MYCN_18555785_ChIP-Seq_MESCs_Mouse1.42136382
71XRN2_22483619_ChIP-Seq_HELA_Human1.40673487
72* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.40470962
73E2F1_18555785_ChIP-Seq_MESCs_Mouse1.37121418
74SCL_19346495_ChIP-Seq_HPC-7_Human1.36600596
75* EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.36067205
76FLI1_27457419_Chip-Seq_LIVER_Mouse1.36041888
77PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.35030288
78NFE2_27457419_Chip-Seq_LIVER_Mouse1.35018839
79PADI4_21655091_ChIP-ChIP_MCF-7_Human1.34631402
80CBP_20019798_ChIP-Seq_JUKART_Human1.33761656
81IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.33761656
82MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.33543027
83MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.33135150
84UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.32920577
85NANOG_19829295_ChIP-Seq_ESCs_Human1.31484601
86SOX2_19829295_ChIP-Seq_ESCs_Human1.31484601
87* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.30714907
88TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.30397709
89SPI1_23547873_ChIP-Seq_NB4_Human1.29125511
90GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.29057427
91PCGF2_27294783_Chip-Seq_NPCs_Mouse1.28583133
92SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.27613779
93POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.26618397
94* THAP11_20581084_ChIP-Seq_MESCs_Mouse1.26020891
95EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.25797622
96MYC_18940864_ChIP-ChIP_HL60_Human1.25253883
97GABP_19822575_ChIP-Seq_HepG2_Human1.22395427
98YY1_21170310_ChIP-Seq_MESCs_Mouse1.20762000
99DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.20507165
100MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.20223188
101RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.19311669
102TP53_22573176_ChIP-Seq_HFKS_Human1.19122403
103SMAD_19615063_ChIP-ChIP_OVARY_Human1.18850910
104STAT4_19710469_ChIP-ChIP_TH1__Mouse1.18382369
105CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.17981810
106CRX_20693478_ChIP-Seq_RETINA_Mouse1.17583750
107NANOG_18555785_Chip-Seq_ESCs_Mouse1.17474575
108SMAD4_21799915_ChIP-Seq_A2780_Human1.16520480
109EGR1_19374776_ChIP-ChIP_THP-1_Human1.15691085
110ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.15567227
111* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.15518283
112* ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.15294541
113CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.15231210
114OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.13027477
115AR_25329375_ChIP-Seq_VCAP_Human1.12495470
116FUS_26573619_Chip-Seq_HEK293_Human1.11893178
117BP1_19119308_ChIP-ChIP_Hs578T_Human1.11664390
118TCF4_22108803_ChIP-Seq_LS180_Human1.11567315
119FOXA1_27270436_Chip-Seq_PROSTATE_Human1.11422140
120FOXA1_25329375_ChIP-Seq_VCAP_Human1.11422140
121TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.11381351
122PCGF2_27294783_Chip-Seq_ESCs_Mouse1.11346662
123EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.10533560
124IRF8_22096565_ChIP-ChIP_GC-B_Human1.10390150
125SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.10184727
126GATA1_22025678_ChIP-Seq_K562_Human1.09964741
127NANOG_18555785_ChIP-Seq_MESCs_Mouse1.08446064
128AR_21909140_ChIP-Seq_LNCAP_Human1.07781634
129P53_22387025_ChIP-Seq_ESCs_Mouse1.06936574
130FOXA1_21572438_ChIP-Seq_LNCaP_Human1.05939163
131TOP2B_26459242_ChIP-Seq_MCF-7_Human1.05240638
132SMAD3_21741376_ChIP-Seq_EPCs_Human1.05163782
133STAT3_23295773_ChIP-Seq_U87_Human1.04970068
134SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.04184397
135STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.03335676
136SALL1_21062744_ChIP-ChIP_HESCs_Human1.03265710
137SUZ12_18555785_Chip-Seq_ESCs_Mouse1.01427149
138KLF5_20875108_ChIP-Seq_MESCs_Mouse1.01391442
139IRF8_21731497_ChIP-ChIP_J774_Mouse1.00596729
140SALL4_22934838_ChIP-ChIP_CD34+_Human1.00480745
141RBPJ_22232070_ChIP-Seq_NCS_Mouse1.00241193
142HTT_18923047_ChIP-ChIP_STHdh_Human1.00166938
143* TCF4_23295773_ChIP-Seq_U87_Human1.00155265
144PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.99430885
145PIAS1_25552417_ChIP-Seq_VCAP_Human0.99381211
146SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.99333410
147* MYB_26560356_Chip-Seq_TH2_Human0.98695561
148OCT4_21477851_ChIP-Seq_ESCs_Mouse0.98012732
149CDX2_22108803_ChIP-Seq_LS180_Human0.97805723
150TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.95940539
151POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.95940539
152POU5F1_16153702_ChIP-ChIP_HESCs_Human0.93874331
153* MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.92455997
154* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.91259771
155BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.85892353
156KDM5A_27292631_Chip-Seq_BREAST_Human0.85440480
157MYB_21317192_ChIP-Seq_ERMYB_Mouse0.85196036
158MYB_26560356_Chip-Seq_TH1_Human0.82520492
159POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.81706955
160SOX2_18555785_ChIP-Seq_MESCs_Mouse0.79928300
161* PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.78911180
162RUNX_20019798_ChIP-Seq_JUKART_Human0.78834435
163CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.75703467

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010094_abnormal_chromosome_stability3.88801607
2MP0008057_abnormal_DNA_replication3.48760986
3MP0008058_abnormal_DNA_repair3.21620073
4MP0008877_abnormal_DNA_methylation3.07153190
5MP0008007_abnormal_cellular_replicative3.06615042
6MP0003693_abnormal_embryo_hatching2.94467793
7MP0002396_abnormal_hematopoietic_system2.92653799
8MP0003787_abnormal_imprinting2.77570717
9MP0001188_hyperpigmentation2.57592882
10MP0003111_abnormal_nucleus_morphology2.53330862
11MP0003077_abnormal_cell_cycle2.52113152
12MP0002877_abnormal_melanocyte_morpholog2.50979599
13MP0003195_calcinosis2.44646267
14MP0006072_abnormal_retinal_apoptosis2.37492843
15MP0003763_abnormal_thymus_physiology2.28736771
16MP0004957_abnormal_blastocyst_morpholog2.27630671
17MP0006292_abnormal_olfactory_placode2.18248934
18MP0005671_abnormal_response_to2.16463390
19MP0003786_premature_aging2.05246436
20MP0004808_abnormal_hematopoietic_stem1.85778313
21MP0005551_abnormal_eye_electrophysiolog1.83710159
22MP0008995_early_reproductive_senescence1.80510567
23MP0005253_abnormal_eye_physiology1.79436434
24MP0002837_dystrophic_cardiac_calcinosis1.78945007
25MP0005084_abnormal_gallbladder_morpholo1.77045755
26MP0000569_abnormal_digit_pigmentation1.74302456
27MP0008932_abnormal_embryonic_tissue1.71380362
28MP0001764_abnormal_homeostasis1.67271822
29MP0002398_abnormal_bone_marrow1.65736336
30MP0001835_abnormal_antigen_presentation1.60033886
31MP0008872_abnormal_physiological_respon1.57701299
32MP0009333_abnormal_splenocyte_physiolog1.54896368
33MP0003121_genomic_imprinting1.53919930
34MP0002132_abnormal_respiratory_system1.47586378
35MP0002095_abnormal_skin_pigmentation1.46183484
36MP0003890_abnormal_embryonic-extraembry1.44498213
37MP0008789_abnormal_olfactory_epithelium1.43207451
38MP0000372_irregular_coat_pigmentation1.42597627
39MP0002736_abnormal_nociception_after1.41251399
40MP0000427_abnormal_hair_cycle1.41181001
41MP0002420_abnormal_adaptive_immunity1.40730896
42MP0000703_abnormal_thymus_morphology1.40061886
43MP0001819_abnormal_immune_cell1.37102792
44MP0003880_abnormal_central_pattern1.36566726
45MP0001800_abnormal_humoral_immune1.35902685
46MP0002210_abnormal_sex_determination1.33646333
47MP0000689_abnormal_spleen_morphology1.29867337
48MP0000716_abnormal_immune_system1.29281449
49MP0005408_hypopigmentation1.29031147
50MP0006036_abnormal_mitochondrial_physio1.27982550
51MP0003724_increased_susceptibility_to1.27241646
52MP0005075_abnormal_melanosome_morpholog1.26032137
53MP0002722_abnormal_immune_system1.25414807
54MP0009697_abnormal_copulation1.25314104
55MP0002452_abnormal_antigen_presenting1.24566925
56MP0002009_preneoplasia1.23039644
57MP0003806_abnormal_nucleotide_metabolis1.22538900
58MP0000350_abnormal_cell_proliferation1.22306293
59MP0001919_abnormal_reproductive_system1.22036949
60MP0001119_abnormal_female_reproductive1.21185089
61MP0005000_abnormal_immune_tolerance1.20635425
62MP0001986_abnormal_taste_sensitivity1.20277869
63MP0001929_abnormal_gametogenesis1.19585300
64MP0002751_abnormal_autonomic_nervous1.19520733
65MP0003718_maternal_effect1.17842567
66MP0005389_reproductive_system_phenotype1.17414017
67MP0002429_abnormal_blood_cell1.16560570
68MP0003943_abnormal_hepatobiliary_system1.16074588
69MP0004043_abnormal_pH_regulation1.15744988
70MP0004142_abnormal_muscle_tone1.15235957
71MP0002234_abnormal_pharynx_morphology1.14880025
72MP0002723_abnormal_immune_serum1.14826693
73MP0001853_heart_inflammation1.14728958
74MP0005395_other_phenotype1.14279769
75MP0000015_abnormal_ear_pigmentation1.13834038
76MP0002090_abnormal_vision1.11455169
77MP0001293_anophthalmia1.11260722
78MP0005394_taste/olfaction_phenotype1.10328622
79MP0005499_abnormal_olfactory_system1.10328622
80MP0001968_abnormal_touch/_nociception1.09768992
81MP0000490_abnormal_crypts_of1.08708840
82MP0002160_abnormal_reproductive_system1.08330240
83MP0005646_abnormal_pituitary_gland1.07547988
84MP0009046_muscle_twitch1.07338361
85MP0002019_abnormal_tumor_incidence1.06998478
86MP0000465_gastrointestinal_hemorrhage1.06753454
87MP0008875_abnormal_xenobiotic_pharmacok1.06052506
88MP0000653_abnormal_sex_gland1.05865535
89MP0005367_renal/urinary_system_phenotyp1.04199743
90MP0000516_abnormal_urinary_system1.04199743
91MP0005387_immune_system_phenotype1.04091632
92MP0001790_abnormal_immune_system1.04091632
93MP0003698_abnormal_male_reproductive1.02531166
94MP0001545_abnormal_hematopoietic_system1.01874699
95MP0005397_hematopoietic_system_phenotyp1.01874699
96MP0001984_abnormal_olfaction1.00013014
97MP0000647_abnormal_sebaceous_gland0.99728526
98MP0001145_abnormal_male_reproductive0.98653616
99MP0002148_abnormal_hypersensitivity_rea0.98466760
100MP0002405_respiratory_system_inflammati0.98434010
101MP0005645_abnormal_hypothalamus_physiol0.98297486
102MP0002102_abnormal_ear_morphology0.98282194
103MP0002419_abnormal_innate_immunity0.96708366
104MP0000313_abnormal_cell_death0.95488033
105MP0009785_altered_susceptibility_to0.95366296
106MP0005410_abnormal_fertilization0.94469011
107MP0003567_abnormal_fetal_cardiomyocyte0.94215326
108MP0006276_abnormal_autonomic_nervous0.93630437
109MP0001324_abnormal_eye_pigmentation0.92989349
110MP0003136_yellow_coat_color0.91748230
111MP0002277_abnormal_respiratory_mucosa0.90708801
112MP0002928_abnormal_bile_duct0.89969484
113MP0004133_heterotaxia0.88376093
114MP0001485_abnormal_pinna_reflex0.88328533
115MP0004215_abnormal_myocardial_fiber0.88175653
116MP0004134_abnormal_chest_morphology0.88126558
117MP0001879_abnormal_lymphatic_vessel0.87409423
118MP0009379_abnormal_foot_pigmentation0.87151410
119MP0001486_abnormal_startle_reflex0.87113999
120MP0000678_abnormal_parathyroid_gland0.86487382
121MP0002138_abnormal_hepatobiliary_system0.86131813
122MP0005025_abnormal_response_to0.86028164
123MP0002933_joint_inflammation0.85803676
124MP0006054_spinal_hemorrhage0.84710429
125MP0001501_abnormal_sleep_pattern0.83131663
126MP0001529_abnormal_vocalization0.81882204
127MP0003123_paternal_imprinting0.81730933
128MP0002272_abnormal_nervous_system0.80957727
129MP0003252_abnormal_bile_duct0.80037400
130MP0005174_abnormal_tail_pigmentation0.79345847
131MP0002163_abnormal_gland_morphology0.78724353
132MP0010307_abnormal_tumor_latency0.78581487
133MP0004147_increased_porphyrin_level0.78561128
134MP0003186_abnormal_redox_activity0.78175480
135MP0005379_endocrine/exocrine_gland_phen0.75788106
136MP0000631_abnormal_neuroendocrine_gland0.75715094
137MP0003646_muscle_fatigue0.74747110
138MP0006035_abnormal_mitochondrial_morpho0.74040544
139MP0002233_abnormal_nose_morphology0.73922177
140MP0009745_abnormal_behavioral_response0.73380136
141MP0001851_eye_inflammation0.73321873
142MP0002938_white_spotting0.71419566
143MP0004885_abnormal_endolymph0.70987901
144MP0002876_abnormal_thyroid_physiology0.70809954
145MP0003011_delayed_dark_adaptation0.70333496
146MP0002638_abnormal_pupillary_reflex0.69365486
147MP0000049_abnormal_middle_ear0.69111374
148MP0005391_vision/eye_phenotype0.68290606
149MP0002006_tumorigenesis0.67784305
150MP0003755_abnormal_palate_morphology0.67231343
151MP0005171_absent_coat_pigmentation0.66869760
152MP0001186_pigmentation_phenotype0.65950252
153MP0002249_abnormal_larynx_morphology0.65344663
154MP0009250_abnormal_appendicular_skeleto0.65152753

Predicted human phenotypes

RankGene SetZ-score
1Chromsome breakage (HP:0040012)3.91300304
2Retrobulbar optic neuritis (HP:0100654)3.89992148
3Optic neuritis (HP:0100653)3.89992148
4Chromosomal breakage induced by crosslinking agents (HP:0003221)3.83053155
5Aplastic anemia (HP:0001915)3.66606270
6Elevated erythrocyte sedimentation rate (HP:0003565)3.65743827
7Myositis (HP:0100614)3.55352273
8Abnormality of the labia minora (HP:0012880)3.51610910
9Birth length less than 3rd percentile (HP:0003561)3.46681036
10Pancreatic cysts (HP:0001737)3.45777351
11Orchitis (HP:0100796)3.30646127
12Irregular epiphyses (HP:0010582)3.08326433
13Molar tooth sign on MRI (HP:0002419)3.02863931
14Abnormality of midbrain morphology (HP:0002418)3.02863931
15Volvulus (HP:0002580)2.84317673
16Methylmalonic acidemia (HP:0002912)2.82316010
17Acute necrotizing encephalopathy (HP:0006965)2.77754841
18Abnormal hair whorl (HP:0010721)2.74148439
19Abnormality of the preputium (HP:0100587)2.71801011
20Myelodysplasia (HP:0002863)2.69289770
21Progressive macrocephaly (HP:0004481)2.68461295
22Nephronophthisis (HP:0000090)2.66062770
23Acute myeloid leukemia (HP:0004808)2.63937665
24Renal cortical cysts (HP:0000803)2.63311528
25Abnormality of chromosome stability (HP:0003220)2.61866792
26Meckel diverticulum (HP:0002245)2.56657321
27Keratoconjunctivitis sicca (HP:0001097)2.55448778
28Acute encephalopathy (HP:0006846)2.53760024
29Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.52479583
30Intestinal atresia (HP:0011100)2.50126013
31Aplasia/Hypoplasia of the uvula (HP:0010293)2.49813137
32IgM deficiency (HP:0002850)2.48269831
33Increased CSF lactate (HP:0002490)2.46836434
34Abnormality of the ileum (HP:0001549)2.45456006
35Mitochondrial inheritance (HP:0001427)2.45252061
36Abnormality of the renal cortex (HP:0011035)2.45063378
37Bone marrow hypocellularity (HP:0005528)2.43527813
38Progressive inability to walk (HP:0002505)2.41915176
39Abnormal delayed hypersensitivity skin test (HP:0002963)2.41718476
40Aplasia/Hypoplasia of the fovea (HP:0008060)2.35671037
41Hypoplasia of the fovea (HP:0007750)2.35671037
4211 pairs of ribs (HP:0000878)2.35584800
43Type 2 muscle fiber atrophy (HP:0003554)2.32645595
44Abolished electroretinogram (ERG) (HP:0000550)2.30258852
45Patellar aplasia (HP:0006443)2.28439649
46Type I transferrin isoform profile (HP:0003642)2.28407851
47Keratoconjunctivitis (HP:0001096)2.27021311
48IgG deficiency (HP:0004315)2.26865713
49Bile duct proliferation (HP:0001408)2.26402273
50Abnormal biliary tract physiology (HP:0012439)2.26402273
51Abnormality of the fingertips (HP:0001211)2.25701284
52Abnormal mitochondria in muscle tissue (HP:0008316)2.25560243
53Thrombocytosis (HP:0001894)2.25432453
54Abnormality of the renal medulla (HP:0100957)2.23521749
55Median cleft lip (HP:0000161)2.21419633
56Hepatocellular necrosis (HP:0001404)2.21231660
57Pulmonary infiltrates (HP:0002113)2.20457794
58Hyperglycinemia (HP:0002154)2.19857929
59Clubbing of toes (HP:0100760)2.19838853
60Abnormality of the duodenum (HP:0002246)2.19650221
61Colon cancer (HP:0003003)2.18638360
62Hepatic necrosis (HP:0002605)2.18144685
63True hermaphroditism (HP:0010459)2.17984197
64Arthropathy (HP:0003040)2.17777775
65Aplasia/Hypoplasia of the tongue (HP:0010295)2.17659201
66Flat capital femoral epiphysis (HP:0003370)2.17391202
67Pancreatic fibrosis (HP:0100732)2.15782001
68Hypothermia (HP:0002045)2.15615830
69Methylmalonic aciduria (HP:0012120)2.14960286
70Encephalitis (HP:0002383)2.14583731
71Abnormality of the heme biosynthetic pathway (HP:0010472)2.12947884
72Congenital primary aphakia (HP:0007707)2.12789931
73Congenital stationary night blindness (HP:0007642)2.12427590
74Decreased activity of mitochondrial respiratory chain (HP:0008972)2.11542953
75Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.11542953
76Abnormality of the fovea (HP:0000493)2.11049566
77Attenuation of retinal blood vessels (HP:0007843)2.10885219
783-Methylglutaconic aciduria (HP:0003535)2.09706851
79Aplasia/Hypoplasia of the patella (HP:0006498)2.09657166
80Tubulointerstitial nephritis (HP:0001970)2.05978225
81Degeneration of anterior horn cells (HP:0002398)2.01409902
82Abnormality of the anterior horn cell (HP:0006802)2.01409902
83Abnormality of aspartate family amino acid metabolism (HP:0010899)2.00880921
84Breast hypoplasia (HP:0003187)2.00300375
85Muscle fiber atrophy (HP:0100295)1.99901088
86Duodenal stenosis (HP:0100867)1.99059889
87Small intestinal stenosis (HP:0012848)1.99059889
88Chronic hepatic failure (HP:0100626)1.98895674
89Gait imbalance (HP:0002141)1.98185016
90Meningitis (HP:0001287)1.98056084
91Abnormality of the pons (HP:0007361)1.97607671
92Abnormal lung lobation (HP:0002101)1.97047585
93Abnormality of the renal collecting system (HP:0004742)1.96852898
94Abnormality of vitamin B metabolism (HP:0004340)1.96259913
95Oligodactyly (hands) (HP:0001180)1.95988149
96Increased hepatocellular lipid droplets (HP:0006565)1.94987491
97Abnormality of incisor morphology (HP:0011063)1.94471666
98Premature graying of hair (HP:0002216)1.93179870
99Nephroblastoma (Wilms tumor) (HP:0002667)1.93103958
100Anencephaly (HP:0002323)1.92813741
101Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.92795723
102Genital tract atresia (HP:0001827)1.91719871
103Sclerocornea (HP:0000647)1.91087235
104Abnormality of the femoral head (HP:0003368)1.90965820
105B lymphocytopenia (HP:0010976)1.90586180
106Abnormality of B cell number (HP:0010975)1.90586180
107Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.90145849
108Absent epiphyses (HP:0010577)1.90145849
109Small hand (HP:0200055)1.89414129
110Abnormality of the epiphysis of the femoral head (HP:0010574)1.89255510
111Recurrent sinusitis (HP:0011108)1.89037484
112Lymphoma (HP:0002665)1.88506525
113Abnormality involving the epiphyses of the lower limbs (HP:0006500)1.86308799
114Abnormality of femoral epiphyses (HP:0006499)1.86308799
115Aortic valve stenosis (HP:0001650)1.86231680
116Postaxial foot polydactyly (HP:0001830)1.85847371
117Constricted visual fields (HP:0001133)1.85568502
118Abnormal respiratory motile cilium morphology (HP:0005938)1.85454232
119Abnormal respiratory epithelium morphology (HP:0012253)1.85454232
120Abnormality of the incisor (HP:0000676)1.85051733
121Congenital hepatic fibrosis (HP:0002612)1.84821715
122Poor coordination (HP:0002370)1.84478813
123Pancreatic islet-cell hyperplasia (HP:0004510)1.83750789
124Gaze-evoked nystagmus (HP:0000640)1.82982658
125Hypoplasia of the pons (HP:0012110)1.82977103
126Supernumerary spleens (HP:0009799)1.82679768
127Medial flaring of the eyebrow (HP:0010747)1.82612249
128Absent frontal sinuses (HP:0002688)1.82087519
129Cystic liver disease (HP:0006706)1.81987717
130Weak cry (HP:0001612)1.81925380
131Lipid accumulation in hepatocytes (HP:0006561)1.81799078
132Small epiphyses (HP:0010585)1.81376820
133Abnormality of T cell physiology (HP:0011840)1.80570018
134Postaxial hand polydactyly (HP:0001162)1.79708039
135Aplasia/Hypoplasia of the tibia (HP:0005772)1.79613751
136Embryonal renal neoplasm (HP:0011794)1.79361976
137Recurrent pneumonia (HP:0006532)1.79294265
138Reduced antithrombin III activity (HP:0001976)1.79039455
139Syringomyelia (HP:0003396)1.78130506
140Spinal cord lesions (HP:0100561)1.78130506
141Short tibia (HP:0005736)1.77949298
142Absent thumb (HP:0009777)1.77888752
143Increased serum lactate (HP:0002151)1.77777771
144Abnormality of methionine metabolism (HP:0010901)1.77571266
145Sloping forehead (HP:0000340)1.76233605
146Abnormality of the intervertebral disk (HP:0005108)1.75776922
147Hypoplastic iliac wings (HP:0002866)1.75383314
148Abnormality of the prostate (HP:0008775)1.75088380
149Optic disc pallor (HP:0000543)1.73244679
150Thyroiditis (HP:0100646)1.73064792
151Ectopic kidney (HP:0000086)1.71971173
152Vaginal atresia (HP:0000148)1.71932287
153Optic nerve coloboma (HP:0000588)1.71782605
154Preaxial hand polydactyly (HP:0001177)1.71511717
155Patchy hypopigmentation of hair (HP:0011365)1.71275332
156Cerebral edema (HP:0002181)1.70913065
157Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.70799616
158Duplicated collecting system (HP:0000081)1.70492062
159Nephrogenic diabetes insipidus (HP:0009806)1.70094479
160Male pseudohermaphroditism (HP:0000037)1.70089657
161Optic nerve hypoplasia (HP:0000609)1.69648483
162Abnormality of the vitamin B12 metabolism (HP:0004341)1.69617041
163Fibular hypoplasia (HP:0003038)1.69585735
164White forelock (HP:0002211)1.68497607
165Dandy-Walker malformation (HP:0001305)1.67931997
166Capillary hemangiomas (HP:0005306)1.67721294
167Astigmatism (HP:0000483)1.67659586
168Limb hypertonia (HP:0002509)1.67197322
169Reticulocytopenia (HP:0001896)1.67070597
170Metaphyseal dysplasia (HP:0100255)1.66317064
171Abnormal spermatogenesis (HP:0008669)1.66274457
172Abnormality of macular pigmentation (HP:0008002)1.63740148
173Glioma (HP:0009733)1.63551173
174Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.62143878
175Oculomotor apraxia (HP:0000657)1.60822748
176Adrenal hypoplasia (HP:0000835)1.60703678
177Neoplasm of the adrenal cortex (HP:0100641)1.60528922
178Triphalangeal thumb (HP:0001199)1.60434439
179Abnormality of serum amino acid levels (HP:0003112)1.60122705

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK3.54624925
2SRPK13.35032554
3TRIM282.89351602
4MKNK12.62645916
5MKNK22.62427742
6TXK2.51237506
7WNK32.48241858
8MAP4K22.47797812
9VRK12.43584675
10STK162.37235991
11CDC72.35258456
12SIK32.10989748
13WEE12.03701379
14CASK1.94157805
15MST41.93280347
16EIF2AK31.91888723
17MUSK1.91779877
18TNIK1.91370289
19NEK11.81661321
20EIF2AK11.81399709
21MAP4K11.80075072
22TSSK61.79487060
23STK241.74000789
24PLK41.73988792
25TEC1.66603517
26IRAK41.64609476
27GRK11.64051017
28NEK61.59872694
29ACVR1B1.59134935
30CDK81.56621977
31AKT31.53047020
32CCNB11.43770633
33ZAK1.41640610
34PRPF4B1.40724315
35IRAK31.40722400
36MAP3K141.38000811
37BUB11.37857106
38PLK31.36188100
39BRSK21.34535955
40BMPR1B1.28445379
41MAP3K121.28351404
42BMPR21.26214312
43TAOK31.22626116
44NLK1.19020924
45YES11.18962577
46EIF2AK21.18234857
47VRK21.14638441
48SGK21.11703193
49ERBB31.10483764
50KIT1.10381098
51TGFBR11.09908881
52FGFR31.07454660
53PLK11.03808381
54OXSR11.03118411
55STK38L1.01737009
56DYRK1A1.01218731
57ATR1.00663370
58MARK30.98659761
59PIM10.94814319
60CDK70.94560392
61RPS6KB20.93245871
62MAP3K40.93241030
63BTK0.91847490
64PIM20.91095420
65CSNK1G10.90735502
66PAK30.89051500
67STK390.88329734
68MAPK130.86925329
69IKBKE0.86483745
70PNCK0.85970858
71PLK20.84934332
72TRPM70.84539219
73AURKB0.83962307
74TLK10.83795677
75INSRR0.79148653
76FGFR20.78945094
77PBK0.78616491
78CHUK0.77343950
79RPS6KB10.76294107
80MAP2K70.75610318
81STK100.75494334
82ITK0.75333425
83BRSK10.72833488
84CSNK1G20.70955979
85TTK0.70784236
86CSNK1G30.70306273
87IRAK10.69526883
88FER0.69052196
89ADRBK20.67945209
90PASK0.67080257
91EPHA30.66376825
92IKBKB0.65952677
93CSF1R0.64043014
94ATM0.63310616
95MAPKAPK50.61706951
96SYK0.61053706
97LYN0.60816509
98STK40.59921314
99DYRK20.59567260
100CHEK10.59297945
101GRK70.58790080
102PIK3CA0.57494955
103CLK10.56966676
104ZAP700.55958627
105TAF10.55890303
106RPS6KA50.55580857
107BCR0.55255514
108NUAK10.53455793
109CSNK2A10.52743679
110CHEK20.52725617
111PRKCE0.52601529
112CDK30.51479244
113LCK0.49705856
114BRD40.49197998
115JAK30.48982248
116WNK40.48975907
117PKN10.48472266
118DYRK30.48387929
119CDK10.46935274
120NEK20.46717089
121CDK20.45724697
122STK30.43601787
123SGK4940.42696878
124SGK2230.42696878
125CSNK1A1L0.42584939
126TNK20.42465888
127CDK90.42321570
128PRKCG0.39615729
129PRKCI0.39147297
130TIE10.34543696
131PRKCQ0.33922844
132PDK20.33298598
133PINK10.32720608
134CAMKK20.32028564
135BCKDK0.31853014
136EPHA40.31420876
137RPS6KA40.30394340
138DAPK20.27024021
139ADRBK10.25370184

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030303.69876595
2Non-homologous end-joining_Homo sapiens_hsa034503.53430570
3Mismatch repair_Homo sapiens_hsa034303.40073129
4RNA polymerase_Homo sapiens_hsa030203.26898945
5Homologous recombination_Homo sapiens_hsa034403.07966543
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.02335353
7Basal transcription factors_Homo sapiens_hsa030222.91987903
8Base excision repair_Homo sapiens_hsa034102.89201203
9Spliceosome_Homo sapiens_hsa030402.68697255
10Fanconi anemia pathway_Homo sapiens_hsa034602.66033940
11Nucleotide excision repair_Homo sapiens_hsa034202.47072371
12RNA degradation_Homo sapiens_hsa030182.41423940
13Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.39032709
14Cell cycle_Homo sapiens_hsa041102.32677044
15Proteasome_Homo sapiens_hsa030502.31450117
16Pyrimidine metabolism_Homo sapiens_hsa002402.23028501
17Propanoate metabolism_Homo sapiens_hsa006402.19030008
18Protein export_Homo sapiens_hsa030602.08486248
19Ribosome_Homo sapiens_hsa030102.00935665
20Oxidative phosphorylation_Homo sapiens_hsa001901.92845849
21RNA transport_Homo sapiens_hsa030131.87877002
22Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.83824907
23Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.80751853
24Primary immunodeficiency_Homo sapiens_hsa053401.78805238
25Steroid biosynthesis_Homo sapiens_hsa001001.66915935
26Parkinsons disease_Homo sapiens_hsa050121.66178707
27Butanoate metabolism_Homo sapiens_hsa006501.53525002
28Maturity onset diabetes of the young_Homo sapiens_hsa049501.45252890
29NF-kappa B signaling pathway_Homo sapiens_hsa040641.38143921
30Purine metabolism_Homo sapiens_hsa002301.36702542
31Epstein-Barr virus infection_Homo sapiens_hsa051691.36293470
32Fatty acid elongation_Homo sapiens_hsa000621.33715661
33Herpes simplex infection_Homo sapiens_hsa051681.32304503
34mRNA surveillance pathway_Homo sapiens_hsa030151.31323009
35Caffeine metabolism_Homo sapiens_hsa002321.29130090
36Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.28879641
37Regulation of autophagy_Homo sapiens_hsa041401.23675992
38One carbon pool by folate_Homo sapiens_hsa006701.23431211
39Intestinal immune network for IgA production_Homo sapiens_hsa046721.21124994
40Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.20714833
41p53 signaling pathway_Homo sapiens_hsa041151.17948576
42Cysteine and methionine metabolism_Homo sapiens_hsa002701.16585416
43Measles_Homo sapiens_hsa051621.16216344
44Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.14142688
45Nitrogen metabolism_Homo sapiens_hsa009101.13317152
46Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.06792818
47Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.05752509
48Linoleic acid metabolism_Homo sapiens_hsa005911.05726484
49Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.04295813
50SNARE interactions in vesicular transport_Homo sapiens_hsa041301.03907955
51Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.01067478
52Hematopoietic cell lineage_Homo sapiens_hsa046401.00632092
53Peroxisome_Homo sapiens_hsa041461.00029748
54Antigen processing and presentation_Homo sapiens_hsa046120.99424870
55RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.96327045
56Transcriptional misregulation in cancer_Homo sapiens_hsa052020.95719854
57Tryptophan metabolism_Homo sapiens_hsa003800.95371884
58Olfactory transduction_Homo sapiens_hsa047400.94510875
59alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.91135049
60Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.87637952
61Viral carcinogenesis_Homo sapiens_hsa052030.84454866
62Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.82744114
63Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.81830681
64NOD-like receptor signaling pathway_Homo sapiens_hsa046210.78678450
65Alzheimers disease_Homo sapiens_hsa050100.76776600
66Sulfur metabolism_Homo sapiens_hsa009200.76190331
67Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.73155969
68T cell receptor signaling pathway_Homo sapiens_hsa046600.72232726
69HTLV-I infection_Homo sapiens_hsa051660.71537662
70Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.71453570
71Allograft rejection_Homo sapiens_hsa053300.71347195
72Circadian rhythm_Homo sapiens_hsa047100.69024374
73Legionellosis_Homo sapiens_hsa051340.68667385
74Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.68395998
75Hepatitis B_Homo sapiens_hsa051610.68189039
76Graft-versus-host disease_Homo sapiens_hsa053320.67513710
77Vitamin B6 metabolism_Homo sapiens_hsa007500.64887843
78Influenza A_Homo sapiens_hsa051640.64115162
79Phototransduction_Homo sapiens_hsa047440.62342948
80Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.62304702
81Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.61970238
82Arachidonic acid metabolism_Homo sapiens_hsa005900.59763731
83Collecting duct acid secretion_Homo sapiens_hsa049660.57017026
84Metabolic pathways_Homo sapiens_hsa011000.55984462
85Leishmaniasis_Homo sapiens_hsa051400.55507534
86Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.54997673
87beta-Alanine metabolism_Homo sapiens_hsa004100.54717341
88Autoimmune thyroid disease_Homo sapiens_hsa053200.52385904
89B cell receptor signaling pathway_Homo sapiens_hsa046620.52290285
90Taste transduction_Homo sapiens_hsa047420.52233024
91Primary bile acid biosynthesis_Homo sapiens_hsa001200.51719566
92Huntingtons disease_Homo sapiens_hsa050160.51223354
93Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.50506389
94Jak-STAT signaling pathway_Homo sapiens_hsa046300.50468311
95Other glycan degradation_Homo sapiens_hsa005110.49026262
96Acute myeloid leukemia_Homo sapiens_hsa052210.47146989
97Retinol metabolism_Homo sapiens_hsa008300.46398933
98Glutathione metabolism_Homo sapiens_hsa004800.46316249
99Thyroid cancer_Homo sapiens_hsa052160.45905891
100Malaria_Homo sapiens_hsa051440.45272572
101Systemic lupus erythematosus_Homo sapiens_hsa053220.45224395
102Colorectal cancer_Homo sapiens_hsa052100.45191935
103Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.45124586
104Fatty acid metabolism_Homo sapiens_hsa012120.44625859
105TGF-beta signaling pathway_Homo sapiens_hsa043500.44322891
106Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.44284303
107Nicotine addiction_Homo sapiens_hsa050330.44083046
108Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.43220758
109Pentose and glucuronate interconversions_Homo sapiens_hsa000400.42030346
110Sphingolipid metabolism_Homo sapiens_hsa006000.41216770
111Apoptosis_Homo sapiens_hsa042100.41088100
112MicroRNAs in cancer_Homo sapiens_hsa052060.40889369
113Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.40365987
114Shigellosis_Homo sapiens_hsa051310.39277000
115Pyruvate metabolism_Homo sapiens_hsa006200.38904578
116Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.37525179
117Small cell lung cancer_Homo sapiens_hsa052220.36437391
118Type I diabetes mellitus_Homo sapiens_hsa049400.35864991
119Prostate cancer_Homo sapiens_hsa052150.35744215
120Oocyte meiosis_Homo sapiens_hsa041140.35300739
121Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.35199123
122Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.35104679
123FoxO signaling pathway_Homo sapiens_hsa040680.34937411
124Chemical carcinogenesis_Homo sapiens_hsa052040.34289217
125Hepatitis C_Homo sapiens_hsa051600.33779828
126Drug metabolism - other enzymes_Homo sapiens_hsa009830.33220604
127TNF signaling pathway_Homo sapiens_hsa046680.33199621
128Serotonergic synapse_Homo sapiens_hsa047260.32329244
129Fatty acid degradation_Homo sapiens_hsa000710.32117805
130Asthma_Homo sapiens_hsa053100.31636645
131Glycerolipid metabolism_Homo sapiens_hsa005610.31632569
132Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.31267334
133Osteoclast differentiation_Homo sapiens_hsa043800.28996536
134Ether lipid metabolism_Homo sapiens_hsa005650.28916019
135Toxoplasmosis_Homo sapiens_hsa051450.28677633
136Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.28323495
137Pancreatic cancer_Homo sapiens_hsa052120.26395479
138Toll-like receptor signaling pathway_Homo sapiens_hsa046200.25277075
139Selenocompound metabolism_Homo sapiens_hsa004500.25145652
140Pathways in cancer_Homo sapiens_hsa052000.24516129
141GABAergic synapse_Homo sapiens_hsa047270.23237805
142N-Glycan biosynthesis_Homo sapiens_hsa005100.23159759
143Non-small cell lung cancer_Homo sapiens_hsa052230.22721112
144Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.22154511
145Alcoholism_Homo sapiens_hsa050340.22122527
146Folate biosynthesis_Homo sapiens_hsa007900.21672079
147PI3K-Akt signaling pathway_Homo sapiens_hsa041510.19990488
148Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.19716012
149Rheumatoid arthritis_Homo sapiens_hsa053230.18486460
150Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.18468177
151Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.18370122

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