ING4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a tumor suppressor protein that contains a PHD-finger, which is a common motif in proteins involved in chromatin remodeling. This protein can bind TP53 and EP300/p300, a component of the histone acetyl transferase complex, suggesting its involvement in the TP53-dependent regulatory pathway. Multiple alternatively spliced transcript variants have been observed that encode distinct proteins. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1pyrimidine nucleobase catabolic process (GO:0006208)7.16271639
2sequestering of actin monomers (GO:0042989)6.41995405
3nucleobase catabolic process (GO:0046113)5.49334671
4regulation of nuclear cell cycle DNA replication (GO:0033262)5.34875598
5behavioral response to nicotine (GO:0035095)4.79788898
6DNA deamination (GO:0045006)4.79424526
7ribosomal small subunit biogenesis (GO:0042274)4.68409492
8DNA damage response, detection of DNA damage (GO:0042769)4.65039594
9negative regulation of synaptic transmission, glutamatergic (GO:0051967)4.52920997
10rRNA modification (GO:0000154)4.45707156
11proteasome assembly (GO:0043248)4.36942950
12DNA replication checkpoint (GO:0000076)4.14310973
13transcription elongation from RNA polymerase III promoter (GO:0006385)4.11411077
14termination of RNA polymerase III transcription (GO:0006386)4.11411077
15neuron cell-cell adhesion (GO:0007158)4.09856152
16postsynaptic membrane organization (GO:0001941)4.03948215
17retinal ganglion cell axon guidance (GO:0031290)4.01368388
18rRNA methylation (GO:0031167)3.90820466
19presynaptic membrane assembly (GO:0097105)3.87442700
20telomere maintenance via semi-conservative replication (GO:0032201)3.83571358
21protein import into peroxisome matrix (GO:0016558)3.82462488
22positive regulation of mitochondrial fission (GO:0090141)3.76992829
23ribonucleoprotein complex biogenesis (GO:0022613)3.75515482
24negative regulation of protein oligomerization (GO:0032460)3.73585401
25presynaptic membrane organization (GO:0097090)3.72416709
26axonal fasciculation (GO:0007413)3.70868898
27establishment of mitochondrion localization (GO:0051654)3.69528776
28limb bud formation (GO:0060174)3.69312528
29neuron recognition (GO:0008038)3.64428344
30negative regulation of telomere maintenance (GO:0032205)3.63982912
31ribosome biogenesis (GO:0042254)3.60750944
32cell migration in hindbrain (GO:0021535)3.60433229
337-methylguanosine mRNA capping (GO:0006370)3.55864890
34ribosomal small subunit assembly (GO:0000028)3.55652075
35daunorubicin metabolic process (GO:0044597)3.51537320
36polyketide metabolic process (GO:0030638)3.51537320
37doxorubicin metabolic process (GO:0044598)3.51537320
38mitochondrial DNA replication (GO:0006264)3.50397614
397-methylguanosine RNA capping (GO:0009452)3.49126960
40RNA capping (GO:0036260)3.49126960
41synapse assembly (GO:0007416)3.48922567
42regulation of double-strand break repair via homologous recombination (GO:0010569)3.48489227
43epithelial cilium movement (GO:0003351)3.46027571
44calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)3.44245660
45maturation of SSU-rRNA (GO:0030490)3.44153703
46DNA-dependent DNA replication (GO:0006261)3.42021191
47RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.41921807
48tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.41921807
49dendritic spine morphogenesis (GO:0060997)3.39118310
50DNA strand elongation involved in DNA replication (GO:0006271)3.38363129
51ribosomal large subunit biogenesis (GO:0042273)3.37679643
52intraciliary transport (GO:0042073)3.35910741
53DNA replication initiation (GO:0006270)3.35125801
54transcription from RNA polymerase I promoter (GO:0006360)3.34811719
55nucleotide transmembrane transport (GO:1901679)3.34451690
56telomere maintenance via recombination (GO:0000722)3.34103055
57auditory behavior (GO:0031223)3.34086197
58platelet dense granule organization (GO:0060155)3.33496717
59gamma-aminobutyric acid transport (GO:0015812)3.33359324
60somite rostral/caudal axis specification (GO:0032525)3.33298529
61DNA strand elongation (GO:0022616)3.32674555
62pseudouridine synthesis (GO:0001522)3.32526143
63regulation of collateral sprouting (GO:0048670)3.29486202
64mitotic recombination (GO:0006312)3.28981431
65exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.28581517
66neural tube formation (GO:0001841)3.28493448
67cellular component biogenesis (GO:0044085)3.28018684
68mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.25763868
69regulation of telomere maintenance via telomerase (GO:0032210)3.25672491
70neuron fate determination (GO:0048664)3.25512642
71synaptic transmission, cholinergic (GO:0007271)3.24593762
72spliceosomal complex assembly (GO:0000245)3.24471610
73spliceosomal snRNP assembly (GO:0000387)3.24278923
74negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator (GO:1902254)3.24232906
75mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.22894495
76regulation of synapse structural plasticity (GO:0051823)3.21570693
77nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.21507183
78deoxyribonucleoside triphosphate metabolic process (GO:0009200)3.21441860
79deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.20592687
80regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.20084007
81transcription-coupled nucleotide-excision repair (GO:0006283)3.19131872
82RNA methylation (GO:0001510)3.17912242
83viral transcription (GO:0019083)3.17786067
84regulation of mammary gland epithelial cell proliferation (GO:0033599)3.16488175
85neurofilament cytoskeleton organization (GO:0060052)3.16272190
86protein targeting to peroxisome (GO:0006625)3.14455071
87establishment of protein localization to peroxisome (GO:0072663)3.14455071
88protein localization to peroxisome (GO:0072662)3.14455071
89protein localization to synapse (GO:0035418)3.13384347
90somite development (GO:0061053)3.11922425
91energy coupled proton transport, down electrochemical gradient (GO:0015985)3.11467809
92ATP synthesis coupled proton transport (GO:0015986)3.11467809
93protein localization to cilium (GO:0061512)3.10759676
94transmission of nerve impulse (GO:0019226)3.09165655
95deoxyribonucleotide biosynthetic process (GO:0009263)3.07860342
96cullin deneddylation (GO:0010388)3.07230498
97regulation of feeding behavior (GO:0060259)3.06120737
98tRNA methylation (GO:0030488)3.04608871
99positive regulation of synapse assembly (GO:0051965)3.02140784
100regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.02112879
101forebrain neuron differentiation (GO:0021879)3.00086008
102translational termination (GO:0006415)2.99684954
103epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.99673682
104termination of RNA polymerase I transcription (GO:0006363)2.98993454
105negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.97908830
106telomere maintenance via telomere lengthening (GO:0010833)2.97173461
107spinal cord association neuron differentiation (GO:0021527)2.97078746
108CENP-A containing nucleosome assembly (GO:0034080)2.96240137
109protein complex biogenesis (GO:0070271)2.95421202
110synaptic transmission, glutamatergic (GO:0035249)2.94010361
111SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.92881422
112ionotropic glutamate receptor signaling pathway (GO:0035235)2.92553685
113transcription elongation from RNA polymerase I promoter (GO:0006362)2.92209622
114central nervous system projection neuron axonogenesis (GO:0021952)2.91760703
115cilium movement (GO:0003341)2.91339571
116regulation of intrinsic apoptotic signaling pathway by p53 class mediator (GO:1902253)2.91236108
117rRNA processing (GO:0006364)2.88548365
118cotranslational protein targeting to membrane (GO:0006613)2.88397836
119protein deneddylation (GO:0000338)2.85769234
120short-term memory (GO:0007614)2.84891132
121protein-cofactor linkage (GO:0018065)2.84392578
122neurotransmitter-gated ion channel clustering (GO:0072578)2.83779446
123regulation of synaptic transmission, glutamatergic (GO:0051966)2.83541120
124ribosome assembly (GO:0042255)2.83513449
125protein targeting to ER (GO:0045047)2.83410673
126nonmotile primary cilium assembly (GO:0035058)2.82514758
127kinetochore assembly (GO:0051382)2.81190027
128translation (GO:0006412)2.81042222
129maturation of 5.8S rRNA (GO:0000460)2.80480740
130respiratory chain complex IV assembly (GO:0008535)2.79624307
131mechanosensory behavior (GO:0007638)2.79418767
132negative regulation of axon guidance (GO:1902668)2.79328517
133negative regulation of epidermis development (GO:0045683)2.79317951
134chromatin remodeling at centromere (GO:0031055)2.78613352
135GDP-mannose metabolic process (GO:0019673)2.78599098
136rRNA metabolic process (GO:0016072)2.78515500
137mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)2.78446449
138positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021102.78446449
139spinal cord development (GO:0021510)2.76726458
140deoxyribonucleoside diphosphate metabolic process (GO:0009186)2.74782669
141response to auditory stimulus (GO:0010996)2.74529201
142peroxisomal transport (GO:0043574)2.73935700
143positive regulation of amino acid transport (GO:0051957)2.73908731
144vocalization behavior (GO:0071625)2.73357759
145transcription elongation from RNA polymerase II promoter (GO:0006368)2.72973785
146regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.72853376
147negative regulation of ligase activity (GO:0051352)2.72579108
148negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.72579108
149G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.72434414
150anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.72427613
151tRNA processing (GO:0008033)2.72038821
152L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.70702615
153nucleotide-excision repair, DNA gap filling (GO:0006297)2.69199509
154signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.67687541
155signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.67687541
156signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.67687541
157mitochondrion transport along microtubule (GO:0047497)2.67621846
158establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.67621846
159rRNA transcription (GO:0009303)2.67406300
160DNA replication-independent nucleosome assembly (GO:0006336)2.67269824
161DNA replication-independent nucleosome organization (GO:0034724)2.67269824
162negative regulation of telomerase activity (GO:0051974)2.67194420
163protein localization to endoplasmic reticulum (GO:0070972)2.66983786
164DNA replication-dependent nucleosome organization (GO:0034723)2.66656957
165DNA replication-dependent nucleosome assembly (GO:0006335)2.66656957
166mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.66628075
167mitochondrial respiratory chain complex I assembly (GO:0032981)2.66628075
168NADH dehydrogenase complex assembly (GO:0010257)2.66628075
169negative regulation of synaptic transmission, GABAergic (GO:0032229)2.65576198
170head development (GO:0060322)2.64815898
171viral mRNA export from host cell nucleus (GO:0046784)2.64393432
172protein polyglutamylation (GO:0018095)2.63980232
173negative regulation of epidermal cell differentiation (GO:0045605)2.63668314
174establishment of protein localization to endoplasmic reticulum (GO:0072599)2.63121115
175receptor recycling (GO:0001881)2.63111467
176DNA-templated transcription, termination (GO:0006353)2.62925936
177positive regulation of viral transcription (GO:0050434)2.62884564
178signal transduction involved in cell cycle checkpoint (GO:0072395)2.62236381
179intracellular protein transmembrane import (GO:0044743)2.61338904
180axon extension involved in axon guidance (GO:0048846)2.60866564
181neuron projection extension involved in neuron projection guidance (GO:1902284)2.60866564
182glutamate receptor signaling pathway (GO:0007215)2.60413180
183epithelial cell differentiation involved in kidney development (GO:0035850)2.60388934
184cell differentiation in spinal cord (GO:0021515)2.60381370
185synapse organization (GO:0050808)2.59645408
186respiratory electron transport chain (GO:0022904)2.58893478
187positive regulation of gastrulation (GO:2000543)2.58639008
188neuronal action potential (GO:0019228)2.58321488
189electron transport chain (GO:0022900)2.56800907
190negative regulation of axon extension (GO:0030517)2.56044801
191activated T cell proliferation (GO:0050798)2.55302428
192synaptic vesicle exocytosis (GO:0016079)2.51001511
193mitochondrial respiratory chain complex assembly (GO:0033108)2.50997308
194neuronal action potential propagation (GO:0019227)2.50038109
195regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.49855628
196regulation of mitochondrial fission (GO:0090140)2.48791753

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.27723236
2E2F7_22180533_ChIP-Seq_HELA_Human4.56053644
3NOTCH1_17114293_ChIP-ChIP_T-ALL_Human4.40522090
4* KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.26978022
5* GABP_17652178_ChIP-ChIP_JURKAT_Human3.70251967
6MYC_18555785_ChIP-Seq_MESCs_Mouse3.57367303
7NR4A2_19515692_ChIP-ChIP_MN9D_Mouse3.51211447
8* JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.49796636
9* EST1_17652178_ChIP-ChIP_JURKAT_Human3.48970731
10* ETS1_20019798_ChIP-Seq_JURKAT_Human3.13647081
11* E2F4_17652178_ChIP-ChIP_JURKAT_Human3.09437831
12KLF5_18264089_ChIP-ChIP_MESCs_Mouse3.05584371
13KLF4_18264089_ChIP-ChIP_MESCs_Mouse3.05584371
14KLF2_18264089_ChIP-ChIP_MESCs_Mouse3.05584371
15ZNF274_21170338_ChIP-Seq_K562_Hela3.03214768
16HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.02693136
17HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.84610976
18GBX2_23144817_ChIP-Seq_PC3_Human2.78560840
19* CREB1_15753290_ChIP-ChIP_HEK293T_Human2.73040481
20E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.70763636
21GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.70619403
22MYC_18358816_ChIP-ChIP_MESCs_Mouse2.66454260
23* TP63_19390658_ChIP-ChIP_HaCaT_Human2.63512317
24CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.62723584
25CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.60597674
26* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.59653290
27CBX2_27304074_Chip-Seq_ESCs_Mouse2.57383199
28IGF1R_20145208_ChIP-Seq_DFB_Human2.56957709
29FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.48817687
30MYC_19079543_ChIP-ChIP_MESCs_Mouse2.48219870
31TAF15_26573619_Chip-Seq_HEK293_Human2.40915915
32VDR_23849224_ChIP-Seq_CD4+_Human2.38694518
33* ELF1_17652178_ChIP-ChIP_JURKAT_Human2.35675924
34REST_21632747_ChIP-Seq_MESCs_Mouse2.32101290
35SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.29153865
36* YY1_21170310_ChIP-Seq_MESCs_Mouse2.29001624
37CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.25204467
38HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.21257451
39EZH2_27304074_Chip-Seq_ESCs_Mouse2.20165896
40TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.18632958
41MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.18381928
42RBPJ_22232070_ChIP-Seq_NCS_Mouse2.18160428
43XRN2_22483619_ChIP-Seq_HELA_Human2.15752280
44CTBP1_25329375_ChIP-Seq_LNCAP_Human2.15242378
45CTBP2_25329375_ChIP-Seq_LNCAP_Human2.15183673
46ZFP57_27257070_Chip-Seq_ESCs_Mouse2.11448734
47MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.10491013
48EED_16625203_ChIP-ChIP_MESCs_Mouse2.09628733
49EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.09221816
50JARID2_20064375_ChIP-Seq_MESCs_Mouse2.04265396
51RNF2_27304074_Chip-Seq_NSC_Mouse2.03531521
52FOXP3_21729870_ChIP-Seq_TREG_Human2.02749569
53THAP11_20581084_ChIP-Seq_MESCs_Mouse2.02571861
54SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.99033104
55REST_18959480_ChIP-ChIP_MESCs_Mouse1.97858251
56* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.96554152
57IRF1_19129219_ChIP-ChIP_H3396_Human1.96352635
58SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.91439963
59TTF2_22483619_ChIP-Seq_HELA_Human1.91089214
60EZH2_27294783_Chip-Seq_ESCs_Mouse1.89048215
61SRF_21415370_ChIP-Seq_HL-1_Mouse1.85582096
62SUZ12_27294783_Chip-Seq_ESCs_Mouse1.84863022
63NOTCH1_21737748_ChIP-Seq_TLL_Human1.84462812
64NELFA_20434984_ChIP-Seq_ESCs_Mouse1.83852883
65BP1_19119308_ChIP-ChIP_Hs578T_Human1.81689518
66POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.81609063
67* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.81334360
68IKZF1_21737484_ChIP-ChIP_HCT116_Human1.77505729
69SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.73650643
70SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.69523758
71NANOG_18555785_ChIP-Seq_MESCs_Mouse1.68121350
72JARID2_20075857_ChIP-Seq_MESCs_Mouse1.66206314
73TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.64000328
74POU3F2_20337985_ChIP-ChIP_501MEL_Human1.63593219
75VDR_22108803_ChIP-Seq_LS180_Human1.61234790
76GABP_19822575_ChIP-Seq_HepG2_Human1.60401032
77DCP1A_22483619_ChIP-Seq_HELA_Human1.58663220
78RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.58487449
79POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.58330603
80* ELK1_19687146_ChIP-ChIP_HELA_Human1.58107476
81FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.57333454
82PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.57174097
83POU5F1_16153702_ChIP-ChIP_HESCs_Human1.54159101
84FUS_26573619_Chip-Seq_HEK293_Human1.53877894
85PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.52616592
86MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.52288384
87PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.51563054
88CIITA_25753668_ChIP-Seq_RAJI_Human1.50542720
89P300_19829295_ChIP-Seq_ESCs_Human1.49874039
90* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.47484114
91KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.45966513
92RNF2_18974828_ChIP-Seq_MESCs_Mouse1.45436080
93EZH2_18974828_ChIP-Seq_MESCs_Mouse1.45436080
94SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.44795557
95NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.44285797
96* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.43402302
97FOXM1_23109430_ChIP-Seq_U2OS_Human1.43200496
98* CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.42038170
99PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.37690051
100RNF2_27304074_Chip-Seq_ESCs_Mouse1.37657812
101* ELK1_22589737_ChIP-Seq_MCF10A_Human1.37309176
102DROSHA_22980978_ChIP-Seq_HELA_Human1.35866168
103SOX2_18555785_ChIP-Seq_MESCs_Mouse1.35808979
104* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.34321450
105* MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.34089516
106* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.34032956
107MYCN_18555785_ChIP-Seq_MESCs_Mouse1.32193911
108ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.29440816
109RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.28992270
110EWS_26573619_Chip-Seq_HEK293_Human1.25097189
111SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.24065428
112ETV2_25802403_ChIP-Seq_MESCs_Mouse1.23865786
113MYC_18940864_ChIP-ChIP_HL60_Human1.22126628
114FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.20347024
115* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.20069257
116AR_25329375_ChIP-Seq_VCAP_Human1.18028745
117SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.17162880
118UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.14737900
119MTF2_20144788_ChIP-Seq_MESCs_Mouse1.12607064
120SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.12443343
121TCF3_18692474_ChIP-Seq_MEFs_Mouse1.12353327
122SMAD4_21799915_ChIP-Seq_A2780_Human1.11669366
123NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.10625971
124* PADI4_21655091_ChIP-ChIP_MCF-7_Human1.08411791
125TOP2B_26459242_ChIP-Seq_MCF-7_Human1.08289075
126BMI1_23680149_ChIP-Seq_NPCS_Mouse1.07370152
127KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.06298153
128ERG_20887958_ChIP-Seq_HPC-7_Mouse1.06265846
129CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.04644258
130* NANOG_16153702_ChIP-ChIP_HESCs_Human1.04176091
131PIAS1_25552417_ChIP-Seq_VCAP_Human1.03469315
132BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.02651260
133TCF3_18692474_ChIP-Seq_MESCs_Mouse1.02454061
134GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.02394979
135* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.01803291
136RING1B_27294783_Chip-Seq_ESCs_Mouse1.01640562
137TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.01428292
138* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.01037918
139TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01036481
140POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.01036481
141* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.00491833
142CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.00337569
143ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.00032197
144TAL1_26923725_Chip-Seq_HPCs_Mouse0.98854663
145AR_21572438_ChIP-Seq_LNCaP_Human0.98387101
146IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.97751946
147CBP_20019798_ChIP-Seq_JUKART_Human0.97751946
148TP53_22573176_ChIP-Seq_HFKS_Human0.96407403
149SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.96136545
150OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.96087189
151* YY1_22570637_ChIP-Seq_MALME-3M_Human0.95750026
152* SOX2_16153702_ChIP-ChIP_HESCs_Human0.94291932
153POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.94182232
154* ZFX_18555785_ChIP-Seq_MESCs_Mouse0.93504610
155SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.92415733
156SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.91571113
157ER_23166858_ChIP-Seq_MCF-7_Human0.91531836
158SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.90518603
159TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.89028362
160KDM5A_27292631_Chip-Seq_BREAST_Human0.88861863
161TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.88543591
162OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.87678904
163EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.87575445
164RUNX2_22187159_ChIP-Seq_PCA_Human0.87357062
165* RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.87074075
166RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.86403850
167* SOX2_18692474_ChIP-Seq_MEFs_Mouse0.86322423
168TP53_20018659_ChIP-ChIP_R1E_Mouse0.86120753
169E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.85922284
170SMAD3_21741376_ChIP-Seq_EPCs_Human0.85653231
171CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.84638521
172PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.82721445
173* POU5F1_18692474_ChIP-Seq_MESCs_Mouse0.82696491
174BCAT_22108803_ChIP-Seq_LS180_Human0.81579777
175KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.80720490
176CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.78261864
177CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.77987302
178DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.77616170
179GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.77298819
180* OCT4_18692474_ChIP-Seq_MEFs_Mouse0.77165880
181CTCF_18555785_ChIP-Seq_MESCs_Mouse0.75357804
182* SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.75262622

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0006292_abnormal_olfactory_placode4.71296908
2MP0003880_abnormal_central_pattern4.03850148
3MP0000566_synostosis3.31598709
4MP0008057_abnormal_DNA_replication2.92920848
5MP0003693_abnormal_embryo_hatching2.86196524
6MP0000778_abnormal_nervous_system2.70179378
7MP0008058_abnormal_DNA_repair2.68844954
8MP0004859_abnormal_synaptic_plasticity2.61844707
9MP0002822_catalepsy2.56780086
10MP0004381_abnormal_hair_follicle2.49228497
11MP0002277_abnormal_respiratory_mucosa2.44726022
12MP0005394_taste/olfaction_phenotype2.41190145
13MP0005499_abnormal_olfactory_system2.41190145
14MP0005075_abnormal_melanosome_morpholog2.39392387
15MP0003111_abnormal_nucleus_morphology2.36874440
16MP0008007_abnormal_cellular_replicative2.30008192
17MP0001984_abnormal_olfaction2.24917634
18MP0008789_abnormal_olfactory_epithelium2.22650103
19MP0004957_abnormal_blastocyst_morpholog2.18996925
20MP0003136_yellow_coat_color2.18771921
21MP0003635_abnormal_synaptic_transmissio2.11617859
22MP0010094_abnormal_chromosome_stability2.09635143
23MP0002736_abnormal_nociception_after2.07924292
24MP0001968_abnormal_touch/_nociception2.06642795
25MP0003077_abnormal_cell_cycle2.03980998
26MP0008932_abnormal_embryonic_tissue2.03918398
27MP0010030_abnormal_orbit_morphology2.00025221
28MP0003890_abnormal_embryonic-extraembry1.99011667
29MP0003011_delayed_dark_adaptation1.97762478
30MP0009745_abnormal_behavioral_response1.95464406
31MP0000049_abnormal_middle_ear1.92797525
32MP0002272_abnormal_nervous_system1.88593193
33MP0003315_abnormal_perineum_morphology1.87807347
34MP0003938_abnormal_ear_development1.82753470
35MP0001188_hyperpigmentation1.82012484
36MP0002063_abnormal_learning/memory/cond1.81401674
37MP0002572_abnormal_emotion/affect_behav1.81082318
38MP0001486_abnormal_startle_reflex1.79050484
39MP0001905_abnormal_dopamine_level1.77870661
40MP0006082_CNS_inflammation1.76340007
41MP0003786_premature_aging1.75419412
42MP0002735_abnormal_chemical_nociception1.73737397
43MP0009379_abnormal_foot_pigmentation1.73559382
44MP0005645_abnormal_hypothalamus_physiol1.69861331
45MP0002064_seizures1.68078564
46MP0002557_abnormal_social/conspecific_i1.67105027
47MP0009046_muscle_twitch1.67046737
48MP0004133_heterotaxia1.64066368
49MP0000955_abnormal_spinal_cord1.60722383
50MP0003941_abnormal_skin_development1.60614512
51MP0003718_maternal_effect1.60415440
52MP0002067_abnormal_sensory_capabilities1.55366831
53MP0001986_abnormal_taste_sensitivity1.54824319
54MP0002751_abnormal_autonomic_nervous1.54668906
55MP0002653_abnormal_ependyma_morphology1.52632160
56MP0000678_abnormal_parathyroid_gland1.52061930
57MP0004270_analgesia1.50586279
58MP0002734_abnormal_mechanical_nocicepti1.46725162
59MP0002184_abnormal_innervation1.45964503
60MP0004885_abnormal_endolymph1.44761068
61MP0005409_darkened_coat_color1.40876139
62MP0003121_genomic_imprinting1.40605625
63MP0005551_abnormal_eye_electrophysiolog1.40584245
64MP0002132_abnormal_respiratory_system1.40498276
65MP0004811_abnormal_neuron_physiology1.40405224
66MP0001970_abnormal_pain_threshold1.39973014
67MP0002882_abnormal_neuron_morphology1.38567740
68MP0002733_abnormal_thermal_nociception1.34829888
69MP0000569_abnormal_digit_pigmentation1.32022863
70MP0002160_abnormal_reproductive_system1.31956515
71MP0002102_abnormal_ear_morphology1.28304063
72MP0006035_abnormal_mitochondrial_morpho1.26137808
73MP0002938_white_spotting1.24491267
74MP0003690_abnormal_glial_cell1.21761011
75MP0000613_abnormal_salivary_gland1.20272879
76MP0004742_abnormal_vestibular_system1.19406483
77MP0005084_abnormal_gallbladder_morpholo1.19388097
78MP0003122_maternal_imprinting1.18652110
79MP0002249_abnormal_larynx_morphology1.18526663
80MP0002638_abnormal_pupillary_reflex1.17958560
81MP0006072_abnormal_retinal_apoptosis1.17809305
82MP0001346_abnormal_lacrimal_gland1.17264482
83MP0002396_abnormal_hematopoietic_system1.15790425
84MP0004142_abnormal_muscle_tone1.12899192
85MP0001286_abnormal_eye_development1.10917018
86MP0008260_abnormal_autophagy1.10686963
87MP0001293_anophthalmia1.09895133
88MP0003937_abnormal_limbs/digits/tail_de1.09655724
89MP0002098_abnormal_vibrissa_morphology1.09411247
90MP0005423_abnormal_somatic_nervous1.09326401
91MP0005386_behavior/neurological_phenoty1.07842550
92MP0004924_abnormal_behavior1.07842550
93MP0002210_abnormal_sex_determination1.06657169
94MP0005257_abnormal_intraocular_pressure1.06552631
95MP0002837_dystrophic_cardiac_calcinosis1.05525186
96MP0005389_reproductive_system_phenotype1.05203577
97MP0001529_abnormal_vocalization1.04991811
98MP0000762_abnormal_tongue_morphology1.04917466
99MP0003119_abnormal_digestive_system1.04734949
100MP0002332_abnormal_exercise_endurance1.01862576
101MP0000313_abnormal_cell_death1.01861319
102MP0005195_abnormal_posterior_eye1.00233621
103MP0000026_abnormal_inner_ear1.00044926
104MP0002152_abnormal_brain_morphology0.99784680
105MP0002752_abnormal_somatic_nervous0.98531924
106MP0000490_abnormal_crypts_of0.97620037
107MP0004145_abnormal_muscle_electrophysio0.97027921
108MP0000383_abnormal_hair_follicle0.96673708
109MP0000015_abnormal_ear_pigmentation0.96589414
110MP0005253_abnormal_eye_physiology0.96518607
111MP0000631_abnormal_neuroendocrine_gland0.96011065
112MP0005248_abnormal_Harderian_gland0.95346769
113MP0001963_abnormal_hearing_physiology0.95112732
114MP0000372_irregular_coat_pigmentation0.94840768
115MP0001485_abnormal_pinna_reflex0.94363878
116MP0002254_reproductive_system_inflammat0.94348509
117MP0002234_abnormal_pharynx_morphology0.93494563
118MP0008569_lethality_at_weaning0.93168210
119MP0002233_abnormal_nose_morphology0.92856256
120MP0003942_abnormal_urinary_system0.91771793
121MP0002066_abnormal_motor_capabilities/c0.91762052
122MP0000350_abnormal_cell_proliferation0.90592056
123MP0003755_abnormal_palate_morphology0.89832237
124MP0002229_neurodegeneration0.89025629
125MP0002876_abnormal_thyroid_physiology0.88974187
126MP0006276_abnormal_autonomic_nervous0.88062336
127MP0002114_abnormal_axial_skeleton0.87975040
128MP0001145_abnormal_male_reproductive0.87504851
129MP0002928_abnormal_bile_duct0.87446099
130MP0004264_abnormal_extraembryonic_tissu0.87099188
131MP0008877_abnormal_DNA_methylation0.86649713
132MP0005391_vision/eye_phenotype0.86502935
133MP0001919_abnormal_reproductive_system0.86186293
134MP0002127_abnormal_cardiovascular_syste0.86038613
135MP0005646_abnormal_pituitary_gland0.85122891
136MP0002069_abnormal_eating/drinking_beha0.85103152
137MP0008995_early_reproductive_senescence0.84505877
138MP0001440_abnormal_grooming_behavior0.83829403
139MP0002085_abnormal_embryonic_tissue0.83251203
140MP0005380_embryogenesis_phenotype0.83095748
141MP0001672_abnormal_embryogenesis/_devel0.83095748
142MP0002932_abnormal_joint_morphology0.83035154
143MP0001502_abnormal_circadian_rhythm0.82528639
144MP0003724_increased_susceptibility_to0.82509974
145MP0002909_abnormal_adrenal_gland0.82225246
146MP0002095_abnormal_skin_pigmentation0.79769078
147MP0001501_abnormal_sleep_pattern0.79259868
148MP0002111_abnormal_tail_morphology0.78855366
149MP0001853_heart_inflammation0.77898141
150MP0005174_abnormal_tail_pigmentation0.75596620
151MP0003633_abnormal_nervous_system0.72872187
152MP0003787_abnormal_imprinting0.72256386
153MP0001324_abnormal_eye_pigmentation0.72178857
154MP0003861_abnormal_nervous_system0.71948894
155MP0000428_abnormal_craniofacial_morphol0.71903185
156MP0000647_abnormal_sebaceous_gland0.71207789
157MP0009250_abnormal_appendicular_skeleto0.70794992
158MP0001929_abnormal_gametogenesis0.69967132
159MP0001119_abnormal_female_reproductive0.69320218
160MP0002177_abnormal_outer_ear0.68680922
161MP0002282_abnormal_trachea_morphology0.68361754
162MP0004147_increased_porphyrin_level0.67852223
163MP0003567_abnormal_fetal_cardiomyocyte0.63205226
164MP0003631_nervous_system_phenotype0.61444461

Predicted human phenotypes

RankGene SetZ-score
1Polyphagia (HP:0002591)4.67888813
2Progressive external ophthalmoplegia (HP:0000590)4.61612674
3Chromosomal breakage induced by crosslinking agents (HP:0003221)4.08367076
4Muscle abnormality related to mitochondrial dysfunction (HP:0003800)3.94460526
5Myokymia (HP:0002411)3.89961177
6True hermaphroditism (HP:0010459)3.78273489
7Gait imbalance (HP:0002141)3.72177511
8Limb dystonia (HP:0002451)3.66654267
93-Methylglutaconic aciduria (HP:0003535)3.59701638
10Medial flaring of the eyebrow (HP:0010747)3.54935584
11Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.51992411
12Chromsome breakage (HP:0040012)3.50571055
13Microvesicular hepatic steatosis (HP:0001414)3.41149929
14Congenital primary aphakia (HP:0007707)3.35276688
15Focal motor seizures (HP:0011153)3.31487812
16Pancreatic fibrosis (HP:0100732)3.22382241
17Meckel diverticulum (HP:0002245)3.20176180
18Nephrogenic diabetes insipidus (HP:0009806)3.19509279
19Nephronophthisis (HP:0000090)3.18226688
20Type I transferrin isoform profile (HP:0003642)3.12832002
21Abnormality of the ileum (HP:0001549)3.06594217
22Brushfield spots (HP:0001088)3.02448341
23Reticulocytopenia (HP:0001896)3.02296018
24Molar tooth sign on MRI (HP:0002419)3.01518247
25Abnormality of midbrain morphology (HP:0002418)3.01518247
26Breast hypoplasia (HP:0003187)2.96144275
27Hypoplasia of the fovea (HP:0007750)2.93808179
28Aplasia/Hypoplasia of the fovea (HP:0008060)2.93808179
29Aplastic anemia (HP:0001915)2.91017785
30Amyotrophic lateral sclerosis (HP:0007354)2.86526120
31Bilateral microphthalmos (HP:0007633)2.85360996
32Aplasia/Hypoplasia of the sacrum (HP:0008517)2.82150613
33Abnormal eating behavior (HP:0100738)2.80658926
34Cerebral hypomyelination (HP:0006808)2.80371964
35Abnormal lung lobation (HP:0002101)2.78076470
36Lissencephaly (HP:0001339)2.76508941
37Aplasia/Hypoplasia of the uvula (HP:0010293)2.74535579
38Abnormality of the preputium (HP:0100587)2.74494212
39Focal seizures (HP:0007359)2.67216570
40Thyroid-stimulating hormone excess (HP:0002925)2.66884067
41Birth length less than 3rd percentile (HP:0003561)2.66393493
42Pachygyria (HP:0001302)2.64075704
43Retinal dysplasia (HP:0007973)2.60837551
44Vaginal atresia (HP:0000148)2.59526412
45Progressive muscle weakness (HP:0003323)2.58936160
46Progressive cerebellar ataxia (HP:0002073)2.56709914
47Nephroblastoma (Wilms tumor) (HP:0002667)2.53333321
48Patellar aplasia (HP:0006443)2.52986455
49Genital tract atresia (HP:0001827)2.52019862
50Abnormal ciliary motility (HP:0012262)2.50746438
51Nasolacrimal duct obstruction (HP:0000579)2.50706015
52Reduced antithrombin III activity (HP:0001976)2.49986331
53Abnormality of the renal medulla (HP:0100957)2.49319786
54Triphalangeal thumb (HP:0001199)2.48671771
55Cortical dysplasia (HP:0002539)2.46363652
56Abnormality of the renal collecting system (HP:0004742)2.45092790
57Aplasia/Hypoplasia of the patella (HP:0006498)2.44848854
58Supernumerary spleens (HP:0009799)2.42961859
59Pendular nystagmus (HP:0012043)2.41962367
60Septo-optic dysplasia (HP:0100842)2.41827573
61Agitation (HP:0000713)2.41313505
62Specific learning disability (HP:0001328)2.40342447
63Duplicated collecting system (HP:0000081)2.39715054
64Abnormal mitochondria in muscle tissue (HP:0008316)2.39499045
65Renal Fanconi syndrome (HP:0001994)2.39454512
66External ophthalmoplegia (HP:0000544)2.38111612
67Embryonal renal neoplasm (HP:0011794)2.37740655
68Aplasia/hypoplasia of the uterus (HP:0008684)2.37131925
69Lipid accumulation in hepatocytes (HP:0006561)2.36200515
70Hepatic necrosis (HP:0002605)2.35553308
71Abnormal respiratory motile cilium physiology (HP:0012261)2.35330457
72Abnormal number of erythroid precursors (HP:0012131)2.32832046
73Partial duplication of thumb phalanx (HP:0009944)2.32622254
74Anencephaly (HP:0002323)2.30738799
75Hypoplasia of the brainstem (HP:0002365)2.30352254
76Aplasia/Hypoplasia of the brainstem (HP:0007362)2.30352254
77Abnormality of cells of the erythroid lineage (HP:0012130)2.29397902
78Anomalous pulmonary venous return (HP:0010772)2.29252212
79Abnormal respiratory motile cilium morphology (HP:0005938)2.28431340
80Abnormal respiratory epithelium morphology (HP:0012253)2.28431340
81Type II lissencephaly (HP:0007260)2.26461902
82Ulnar claw (HP:0001178)2.24119528
83Duodenal stenosis (HP:0100867)2.22603218
84Small intestinal stenosis (HP:0012848)2.22603218
85Impulsivity (HP:0100710)2.20190759
86Cystic liver disease (HP:0006706)2.17591658
87Granulocytopenia (HP:0001913)2.15346883
88Stomach cancer (HP:0012126)2.12882260
89Progressive macrocephaly (HP:0004481)2.12280274
90Abnormality of the fovea (HP:0000493)2.11866265
91Short tibia (HP:0005736)2.10835623
92Sclerocornea (HP:0000647)2.10259211
93Postaxial hand polydactyly (HP:0001162)2.09545220
94Hemiparesis (HP:0001269)2.08959779
95Rib fusion (HP:0000902)2.08380323
96Acute necrotizing encephalopathy (HP:0006965)2.08247516
97Drooling (HP:0002307)2.08221057
98Increased intramyocellular lipid droplets (HP:0012240)2.08050431
99Amblyopia (HP:0000646)2.07291266
100Bone marrow hypocellularity (HP:0005528)2.06713605
101Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.06077594
102Increased serum lactate (HP:0002151)2.05989694
103Broad foot (HP:0001769)2.05897679
104Mitochondrial inheritance (HP:0001427)2.05828872
105Microretrognathia (HP:0000308)2.05819136
106Atrophy/Degeneration involving motor neurons (HP:0007373)2.05458478
107Absent radius (HP:0003974)2.04766684
108Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.04719687
109Secondary amenorrhea (HP:0000869)2.04364735
110Macrocytic anemia (HP:0001972)2.03914917
111Pallor (HP:0000980)2.03008687
112Sex reversal (HP:0012245)2.01758977
113Abnormal sex determination (HP:0012244)2.01758977
114Absent forearm bone (HP:0003953)2.01473440
115Aplasia involving forearm bones (HP:0009822)2.01473440
116Occipital encephalocele (HP:0002085)2.01108724
117Atonic seizures (HP:0010819)2.00966885
118Split foot (HP:0001839)2.00664736
119Poor coordination (HP:0002370)2.00464496
120Abnormality of the lacrimal duct (HP:0011481)2.00406684
121Rough bone trabeculation (HP:0100670)1.99675108
122Acute encephalopathy (HP:0006846)1.99452625
123Excessive salivation (HP:0003781)1.99325202
124Aplasia/Hypoplasia of the earlobes (HP:0009906)1.98535619
125Facial cleft (HP:0002006)1.97907343
126Abnormal protein glycosylation (HP:0012346)1.97763692
127Abnormal glycosylation (HP:0012345)1.97763692
128Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.97763692
129Abnormal protein N-linked glycosylation (HP:0012347)1.97763692
130Optic disc pallor (HP:0000543)1.97748736
131Decreased testicular size (HP:0008734)1.97502679
132Duplication of thumb phalanx (HP:0009942)1.97255091
133Failure to thrive in infancy (HP:0001531)1.96172851
134Dialeptic seizures (HP:0011146)1.96076667
135Abnormality of the pulmonary veins (HP:0011718)1.95080570
136Aplasia/Hypoplasia of the spleen (HP:0010451)1.93785685
137Abnormality of the labia minora (HP:0012880)1.93044084
138Abnormality of chromosome stability (HP:0003220)1.92965002
139Premature ovarian failure (HP:0008209)1.92461770
140Aplasia/Hypoplasia of the tibia (HP:0005772)1.92264406
141Chronic hepatic failure (HP:0100626)1.92039698
142Partial duplication of the phalanx of hand (HP:0009999)1.91833103
143Abolished electroretinogram (ERG) (HP:0000550)1.91276108
144Hepatocellular necrosis (HP:0001404)1.90845597
145Pancreatic cysts (HP:0001737)1.90481623
146Osteomalacia (HP:0002749)1.90349367
147Rectal fistula (HP:0100590)1.90332131
148Rectovaginal fistula (HP:0000143)1.90332131
149Abnormality of renal resorption (HP:0011038)1.90124665
150Clubbing of toes (HP:0100760)1.89049813
151Hyperventilation (HP:0002883)1.88817338
152Emotional lability (HP:0000712)1.86976289
153Exercise intolerance (HP:0003546)1.86956478
154Postaxial foot polydactyly (HP:0001830)1.86445140
155Concave nail (HP:0001598)1.86192327
156Degeneration of the lateral corticospinal tracts (HP:0002314)1.85173543
157Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.85173543
158Oligodactyly (hands) (HP:0001180)1.85058122
159Increased CSF lactate (HP:0002490)1.83874480
160Horseshoe kidney (HP:0000085)1.83754441
161Spastic tetraplegia (HP:0002510)1.83632322
162Abnormality of the corticospinal tract (HP:0002492)1.83255509
163Increased hepatocellular lipid droplets (HP:0006565)1.83128245
164Trismus (HP:0000211)1.83068539
165Cleft eyelid (HP:0000625)1.83042499
166Asplenia (HP:0001746)1.82870779
167Febrile seizures (HP:0002373)1.82682193
168Optic nerve hypoplasia (HP:0000609)1.82585653
169Severe visual impairment (HP:0001141)1.81903617
170Embryonal neoplasm (HP:0002898)1.81553309
171Esotropia (HP:0000565)1.81042966
172Abnormality of the septum pellucidum (HP:0007375)1.80905043
173Polydipsia (HP:0001959)1.80215828
174Abnormal drinking behavior (HP:0030082)1.80215828
175Congenital stationary night blindness (HP:0007642)1.79959008
176Poor suck (HP:0002033)1.79825830
177Retinitis pigmentosa (HP:0000510)1.79224508
178Abnormality of the duodenum (HP:0002246)1.79125769
179Aplasia/Hypoplasia of the lens (HP:0008063)1.77853778
180Male pseudohermaphroditism (HP:0000037)1.76907314
181Hypothermia (HP:0002045)1.76641208
182Type 2 muscle fiber atrophy (HP:0003554)1.76401476
183Testicular atrophy (HP:0000029)1.75825302
184Tracheoesophageal fistula (HP:0002575)1.75471903
185Abnormality of the nasolacrimal system (HP:0000614)1.74988356
186Myelodysplasia (HP:0002863)1.74900903

Predicted kinase interactions (KEA)

RankGene SetZ-score
1IRAK35.22003029
2STK164.21664397
3PLK43.76022363
4BUB13.68302568
5IRAK43.18003978
6MAP4K23.04917039
7MARK13.03721991
8IRAK23.00944889
9SRPK12.98302300
10ZAK2.70980342
11TRIM282.55825117
12MAP3K42.48708266
13IRAK12.41881931
14PASK2.32166538
15NTRK22.09129706
16WNK32.02488594
17ADRBK21.99853544
18WEE11.96151678
19EPHA31.92244776
20TLK11.90225009
21VRK11.89054098
22TTK1.87378513
23MAP2K41.82831846
24DYRK31.81123696
25EPHA41.78840261
26INSRR1.72808167
27EPHB21.66361712
28DYRK1B1.65967452
29DYRK21.48444250
30GRK11.47493737
31CASK1.43675807
32TNIK1.43199613
33MKNK11.43136843
34EPHA21.42457886
35SIK21.39148526
36MINK11.38283321
37CSNK1G21.37981050
38EIF2AK21.35440378
39MKNK21.35353989
40MAPK151.34905194
41CAMKK11.32339080
42TAOK31.30000620
43UHMK11.28893534
44PLK11.28024152
45NME21.24692384
46GRK51.20468227
47CLK11.19344749
48TESK21.17461358
49GRK71.16328003
50EIF2AK11.15983851
51MAP3K111.13149671
52CDK71.12158496
53RPS6KA41.10898105
54ACVR1B1.07395854
55YES11.06352276
56CDK121.03735807
57PKN11.02393474
58BLK1.02357237
59PRKCI1.02202943
60PRKCG1.01708098
61MAPK70.99375453
62CSNK1A1L0.98026886
63PRPF4B0.97665727
64MAP3K120.97391351
65EIF2AK30.96404473
66CSF1R0.96171319
67CSNK1G10.94262100
68CHEK20.91871246
69GRK60.89113058
70ATR0.88659777
71NTRK30.87775611
72PAK30.87391992
73CDK190.86248405
74AURKA0.83410244
75PLK30.82895471
76TSSK60.82001146
77SGK2230.81257993
78SGK4940.81257993
79FGR0.80911841
80PAK60.79401315
81CAMKK20.78908047
82BMPR1B0.78796436
83DAPK20.77135321
84BRD40.77121241
85CDK50.74757890
86AKT30.73829145
87PAK40.72451385
88TAOK20.72068986
89NEK60.71781656
90CDC70.71662049
91NLK0.68280277
92PBK0.67551927
93ERBB30.66779118
94AURKB0.65280894
95PRKCZ0.65147765
96CDK140.61974869
97CAMK2A0.60540070
98MST40.59781576
99NME10.59245869
100CAMK2B0.58570970
101RPS6KA50.56783260
102PRKACA0.54698136
103PHKG10.54458739
104PHKG20.54458739
105ITK0.54272442
106MAP3K60.53188342
107PINK10.53022857
108BCR0.52973897
109SGK20.52692213
110NUAK10.52073550
111CDK30.51759513
112MUSK0.51044325
113CDK180.50958391
114MAPK130.50944913
115PIM20.50730982
116MATK0.49614776
117OXSR10.49513598
118TYRO30.49443370
119KSR10.49439397
120CDK11A0.49156216
121PRKCE0.48785976
122CHEK10.48741386
123FGFR20.48009196
124EPHB10.47864099
125MAP3K50.47206558
126CDK150.46993493
127PNCK0.45815727
128TNK20.45276602
129IKBKB0.44922594
130FYN0.44239676
131DYRK1A0.43955517
132RPS6KB20.43078796
133CSNK2A10.42893633
134STK40.40372839
135ADRBK10.40085081
136CAMK10.39926591
137BRAF0.39756785
138NEK20.38626453
139MARK20.38111774
140CSNK1A10.37781890
141FES0.37438163
142TGFBR20.37336331
143KIT0.36678434
144CDK80.36391251
145PRKCQ0.36108368
146SYK0.35867876
147PAK10.35744920
148TEC0.35700922
149MAPK40.35472004
150FRK0.34854267
151TESK10.34717204
152PRKG10.34275793
153MAP2K60.34203984
154TXK0.33409155
155CCNB10.32616520
156BRSK20.32133279
157ATM0.31913554
158KDR0.31849860
159LIMK10.31086638
160CDK20.29570629
161CSNK1G30.29540467
162MAP2K20.29224359
163STK100.28683122
164BCKDK0.28667169
165CDK10.28633365
166CSNK2A20.28605232
167MAP2K70.28165985
168SIK30.27618208

Predicted pathways (KEGG)

RankGene SetZ-score
1RNA polymerase_Homo sapiens_hsa030204.05057757
2Ribosome_Homo sapiens_hsa030103.99184497
3Nicotine addiction_Homo sapiens_hsa050333.81911043
4DNA replication_Homo sapiens_hsa030303.63019376
5Fanconi anemia pathway_Homo sapiens_hsa034603.13455610
6Proteasome_Homo sapiens_hsa030503.09371545
7Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.02807836
8Mismatch repair_Homo sapiens_hsa034302.94346823
9Spliceosome_Homo sapiens_hsa030402.91809591
10Homologous recombination_Homo sapiens_hsa034402.78465584
11Pyrimidine metabolism_Homo sapiens_hsa002402.62180360
12Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.40178458
13Basal transcription factors_Homo sapiens_hsa030222.28867958
14Base excision repair_Homo sapiens_hsa034102.27069343
15Nucleotide excision repair_Homo sapiens_hsa034202.21594204
16GABAergic synapse_Homo sapiens_hsa047272.09725350
17Oxidative phosphorylation_Homo sapiens_hsa001902.05204229
18Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.02648004
19Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.96298909
20Taste transduction_Homo sapiens_hsa047421.95584816
21Morphine addiction_Homo sapiens_hsa050321.93050538
22Collecting duct acid secretion_Homo sapiens_hsa049661.91992279
23Protein export_Homo sapiens_hsa030601.90325161
24RNA transport_Homo sapiens_hsa030131.86837874
25Cocaine addiction_Homo sapiens_hsa050301.83669216
26Non-homologous end-joining_Homo sapiens_hsa034501.72360413
27Synaptic vesicle cycle_Homo sapiens_hsa047211.72075005
28RNA degradation_Homo sapiens_hsa030181.70455978
29Parkinsons disease_Homo sapiens_hsa050121.70447047
30Vitamin B6 metabolism_Homo sapiens_hsa007501.69921619
31Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.65067199
32Cell cycle_Homo sapiens_hsa041101.65013143
33Axon guidance_Homo sapiens_hsa043601.62185801
34Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.61370689
35Glutamatergic synapse_Homo sapiens_hsa047241.57772902
36Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.55480671
37Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.54477509
38Purine metabolism_Homo sapiens_hsa002301.53503968
39Circadian entrainment_Homo sapiens_hsa047131.52894895
40Huntingtons disease_Homo sapiens_hsa050161.51277177
41Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.50999876
42Butanoate metabolism_Homo sapiens_hsa006501.48458197
43Arachidonic acid metabolism_Homo sapiens_hsa005901.46629142
44Dopaminergic synapse_Homo sapiens_hsa047281.44027976
45Peroxisome_Homo sapiens_hsa041461.43104153
46One carbon pool by folate_Homo sapiens_hsa006701.36836333
47Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.20714420
48Serotonergic synapse_Homo sapiens_hsa047261.20457058
49Amphetamine addiction_Homo sapiens_hsa050311.18519687
50p53 signaling pathway_Homo sapiens_hsa041151.18221909
51Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.12387437
52mRNA surveillance pathway_Homo sapiens_hsa030151.11998441
53Alzheimers disease_Homo sapiens_hsa050101.08749886
54Other glycan degradation_Homo sapiens_hsa005111.07571784
55Linoleic acid metabolism_Homo sapiens_hsa005911.06553518
56Olfactory transduction_Homo sapiens_hsa047401.06197961
57Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.96425162
58Epstein-Barr virus infection_Homo sapiens_hsa051690.95096081
59Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.94942480
60Sphingolipid metabolism_Homo sapiens_hsa006000.94927873
61Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.92698656
62Cholinergic synapse_Homo sapiens_hsa047250.92199135
63Folate biosynthesis_Homo sapiens_hsa007900.92040896
64SNARE interactions in vesicular transport_Homo sapiens_hsa041300.90855619
65Insulin secretion_Homo sapiens_hsa049110.90062572
66Ether lipid metabolism_Homo sapiens_hsa005650.85801445
67Phototransduction_Homo sapiens_hsa047440.84966734
68Basal cell carcinoma_Homo sapiens_hsa052170.84938392
69Gap junction_Homo sapiens_hsa045400.84668631
70alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.81756787
71Steroid biosynthesis_Homo sapiens_hsa001000.81153083
72Nitrogen metabolism_Homo sapiens_hsa009100.79493564
73Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.78438368
74Long-term depression_Homo sapiens_hsa047300.76482400
75Primary immunodeficiency_Homo sapiens_hsa053400.75724535
76Regulation of autophagy_Homo sapiens_hsa041400.75693712
77Phagosome_Homo sapiens_hsa041450.75542489
78Primary bile acid biosynthesis_Homo sapiens_hsa001200.72921124
79Glutathione metabolism_Homo sapiens_hsa004800.71866668
80Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.70781039
81Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.67495211
82Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.64353558
83cAMP signaling pathway_Homo sapiens_hsa040240.63672406
84Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.62391649
85Metabolic pathways_Homo sapiens_hsa011000.60504310
86Fructose and mannose metabolism_Homo sapiens_hsa000510.58586209
87Herpes simplex infection_Homo sapiens_hsa051680.58499307
88Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.57085266
89Chemical carcinogenesis_Homo sapiens_hsa052040.56476195
90Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.55553899
91Hedgehog signaling pathway_Homo sapiens_hsa043400.54892267
92Drug metabolism - other enzymes_Homo sapiens_hsa009830.54341886
93Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.53391570
94Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.53343378
95Notch signaling pathway_Homo sapiens_hsa043300.52931540
96Tryptophan metabolism_Homo sapiens_hsa003800.52408642
97Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.51456395
98Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.51449930
99Oxytocin signaling pathway_Homo sapiens_hsa049210.50691155
100Transcriptional misregulation in cancer_Homo sapiens_hsa052020.49183592
101RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.49170451
102NF-kappa B signaling pathway_Homo sapiens_hsa040640.48998438
103Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.47754144
104Systemic lupus erythematosus_Homo sapiens_hsa053220.46673451
105Rheumatoid arthritis_Homo sapiens_hsa053230.45291293
106Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.45146959
107Pentose phosphate pathway_Homo sapiens_hsa000300.44901295
108Calcium signaling pathway_Homo sapiens_hsa040200.44364884
109Galactose metabolism_Homo sapiens_hsa000520.43182000
110Salivary secretion_Homo sapiens_hsa049700.41995397
111Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.39919252
112Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.39687704
113Tyrosine metabolism_Homo sapiens_hsa003500.39416969
114Cardiac muscle contraction_Homo sapiens_hsa042600.39194626
115Propanoate metabolism_Homo sapiens_hsa006400.38818864
116Thyroid cancer_Homo sapiens_hsa052160.38007404
117Cyanoamino acid metabolism_Homo sapiens_hsa004600.36890611
118Ras signaling pathway_Homo sapiens_hsa040140.36746840
119Salmonella infection_Homo sapiens_hsa051320.36607478
120Maturity onset diabetes of the young_Homo sapiens_hsa049500.34853434
121Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.33870883
122Gastric acid secretion_Homo sapiens_hsa049710.32392751
123Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.31675356
124Chemokine signaling pathway_Homo sapiens_hsa040620.31118949
125Hematopoietic cell lineage_Homo sapiens_hsa046400.30765388
126Steroid hormone biosynthesis_Homo sapiens_hsa001400.30656368
127Sulfur relay system_Homo sapiens_hsa041220.30491703
128HTLV-I infection_Homo sapiens_hsa051660.30309889
129Intestinal immune network for IgA production_Homo sapiens_hsa046720.30024965
130Pathways in cancer_Homo sapiens_hsa052000.29413912
131Autoimmune thyroid disease_Homo sapiens_hsa053200.29348723
132Wnt signaling pathway_Homo sapiens_hsa043100.29180748
133Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.29085219
134Allograft rejection_Homo sapiens_hsa053300.28280319
135Fatty acid elongation_Homo sapiens_hsa000620.27387801
136Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.27366451
137Renin secretion_Homo sapiens_hsa049240.26451616
138Viral carcinogenesis_Homo sapiens_hsa052030.25145861
139ABC transporters_Homo sapiens_hsa020100.25042525
140Type II diabetes mellitus_Homo sapiens_hsa049300.23342713
141Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.23225379
142Alcoholism_Homo sapiens_hsa050340.23084682
143Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.21813864
144Retinol metabolism_Homo sapiens_hsa008300.20405976
145Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.19869769
146Glycerophospholipid metabolism_Homo sapiens_hsa005640.19854713
147Dilated cardiomyopathy_Homo sapiens_hsa054140.19213228
148Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.17742092
149Melanogenesis_Homo sapiens_hsa049160.17681713
150Measles_Homo sapiens_hsa051620.16615995
151Pentose and glucuronate interconversions_Homo sapiens_hsa000400.16435373
152N-Glycan biosynthesis_Homo sapiens_hsa005100.16435230
153Hippo signaling pathway_Homo sapiens_hsa043900.14162985
154MicroRNAs in cancer_Homo sapiens_hsa052060.12945207
155Glycosaminoglycan degradation_Homo sapiens_hsa005310.12367550
156Oocyte meiosis_Homo sapiens_hsa041140.11287249
157Graft-versus-host disease_Homo sapiens_hsa053320.10603221

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