ING5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a tumor suppressor protein that inhibits cell growth and induces apoptosis. This protein contains a PHD-type zinc finger. It interacts with tumor suppressor p53 and p300, a component of the histone acetyl transferase complex, suggesting a role in transcriptional regulation. Alternative splicing and the use of multiple promoters and 3' terminal exons results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1behavioral response to nicotine (GO:0035095)6.20736526
2nuclear pore complex assembly (GO:0051292)5.56198652
3nuclear pore organization (GO:0006999)5.41958311
4IMP biosynthetic process (GO:0006188)4.84304753
5DNA replication initiation (GO:0006270)4.54152060
6pore complex assembly (GO:0046931)4.41442267
7DNA strand elongation involved in DNA replication (GO:0006271)4.37069723
8telomere maintenance via semi-conservative replication (GO:0032201)4.17677798
9DNA strand elongation (GO:0022616)4.17596081
10IMP metabolic process (GO:0046040)4.17000755
11nucleobase biosynthetic process (GO:0046112)4.12537300
12mitotic nuclear envelope disassembly (GO:0007077)4.11221829
13negative regulation of translation, ncRNA-mediated (GO:0040033)4.08608993
14regulation of translation, ncRNA-mediated (GO:0045974)4.08608993
15negative regulation of translation involved in gene silencing by miRNA (GO:0035278)4.08608993
16purine nucleobase biosynthetic process (GO:0009113)4.02980929
17kinetochore organization (GO:0051383)4.02957927
18DNA replication checkpoint (GO:0000076)3.99891040
19dosage compensation (GO:0007549)3.89400515
20telomere maintenance via recombination (GO:0000722)3.85184536
21regulation of nuclear cell cycle DNA replication (GO:0033262)3.78675091
22nuclear envelope disassembly (GO:0051081)3.76888445
23membrane disassembly (GO:0030397)3.76888445
24ribosome biogenesis (GO:0042254)3.73792142
25sulfation (GO:0051923)3.73077371
26mitotic metaphase plate congression (GO:0007080)3.70642770
27mitotic recombination (GO:0006312)3.69153782
28protein localization to kinetochore (GO:0034501)3.68853405
29positive regulation of CREB transcription factor activity (GO:0032793)3.67735710
30DNA unwinding involved in DNA replication (GO:0006268)3.66022209
31chromatin remodeling at centromere (GO:0031055)3.65762665
32kinetochore assembly (GO:0051382)3.63005061
33CENP-A containing nucleosome assembly (GO:0034080)3.61726285
34somatic diversification of immune receptors via somatic mutation (GO:0002566)3.61295810
35somatic hypermutation of immunoglobulin genes (GO:0016446)3.61295810
36formation of translation preinitiation complex (GO:0001731)3.56808656
37DNA replication-dependent nucleosome assembly (GO:0006335)3.47396519
38DNA replication-dependent nucleosome organization (GO:0034723)3.47396519
39nephron epithelium morphogenesis (GO:0072088)3.43985778
40nephron tubule morphogenesis (GO:0072078)3.43985778
41ribosomal small subunit assembly (GO:0000028)3.41689860
42maturation of SSU-rRNA (GO:0030490)3.39381720
43telomere maintenance via telomere lengthening (GO:0010833)3.39311066
44DNA replication-independent nucleosome organization (GO:0034724)3.38631817
45DNA replication-independent nucleosome assembly (GO:0006336)3.38631817
46positive regulation of fatty acid beta-oxidation (GO:0032000)3.37037429
47regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.33615449
48fucose catabolic process (GO:0019317)3.32911884
49L-fucose metabolic process (GO:0042354)3.32911884
50L-fucose catabolic process (GO:0042355)3.32911884
51nucleotide-excision repair, DNA gap filling (GO:0006297)3.29560157
52tryptophan catabolic process (GO:0006569)3.24413363
53indole-containing compound catabolic process (GO:0042436)3.24413363
54indolalkylamine catabolic process (GO:0046218)3.24413363
55metaphase plate congression (GO:0051310)3.20650809
56maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.18031333
57tryptophan metabolic process (GO:0006568)3.15217199
58DNA duplex unwinding (GO:0032508)3.15057794
59ribonucleoprotein complex biogenesis (GO:0022613)3.13889918
60DNA geometric change (GO:0032392)3.13789971
61meiotic chromosome segregation (GO:0045132)3.13635535
62response to pheromone (GO:0019236)3.13138676
63protein K6-linked ubiquitination (GO:0085020)3.12032807
64regulation of mitotic spindle checkpoint (GO:1903504)3.10112465
65regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.10112465
66regulation of spindle organization (GO:0090224)3.09200798
67folic acid-containing compound biosynthetic process (GO:0009396)3.08404615
68replication fork processing (GO:0031297)3.08222013
69regulation of double-strand break repair via homologous recombination (GO:0010569)3.06016826
70protein localization to chromosome, centromeric region (GO:0071459)3.05297380
71telomere maintenance (GO:0000723)3.04738928
72negative regulation of telomere maintenance (GO:0032205)3.04703100
73regulation of posttranscriptional gene silencing (GO:0060147)3.04423937
74regulation of gene silencing by miRNA (GO:0060964)3.04423937
75regulation of gene silencing by RNA (GO:0060966)3.04423937
76mitotic sister chromatid segregation (GO:0000070)3.04406193
77telomere organization (GO:0032200)3.03342024
78positive regulation of fatty acid oxidation (GO:0046321)3.03333532
79establishment of chromosome localization (GO:0051303)3.00299649
80DNA synthesis involved in DNA repair (GO:0000731)2.99081956
81transcription-coupled nucleotide-excision repair (GO:0006283)2.96864341
82histone exchange (GO:0043486)2.96342077
83ribosome assembly (GO:0042255)2.94755195
84rRNA modification (GO:0000154)2.94672941
85mismatch repair (GO:0006298)2.93813600
86regulation of hippo signaling (GO:0035330)2.93300753
87snRNA processing (GO:0016180)2.90708288
88* DNA replication (GO:0006260)2.89672156
89DNA deamination (GO:0045006)2.87550658
90mitotic chromosome condensation (GO:0007076)2.86135048
91protein import into peroxisome matrix (GO:0016558)2.85958651
92viral mRNA export from host cell nucleus (GO:0046784)2.84940888
93regulation of helicase activity (GO:0051095)2.84920396
94neuronal action potential (GO:0019228)2.84429747
95indolalkylamine metabolic process (GO:0006586)2.83614189
96histone H3-K9 methylation (GO:0051567)2.83285944
97rRNA processing (GO:0006364)2.82952936
98positive regulation of chromosome segregation (GO:0051984)2.82903746
99nuclear envelope organization (GO:0006998)2.82523285
100mRNA transport (GO:0051028)2.82160666
101sister chromatid segregation (GO:0000819)2.78890925
102histone H4-K12 acetylation (GO:0043983)2.76849846
103maturation of 5.8S rRNA (GO:0000460)2.75757867
104spinal cord motor neuron differentiation (GO:0021522)2.74397057
105regulation of histone H3-K9 methylation (GO:0051570)2.74002978
106detection of light stimulus involved in visual perception (GO:0050908)2.73245069
107detection of light stimulus involved in sensory perception (GO:0050962)2.73245069
108rRNA metabolic process (GO:0016072)2.72977926
109spliceosomal snRNP assembly (GO:0000387)2.72780203
110intra-S DNA damage checkpoint (GO:0031573)2.72614789
111ribosomal large subunit biogenesis (GO:0042273)2.71717394
112termination of RNA polymerase I transcription (GO:0006363)2.71475137
113attachment of spindle microtubules to kinetochore (GO:0008608)2.71360989
114transcription from RNA polymerase I promoter (GO:0006360)2.71342056
115histone mRNA metabolic process (GO:0008334)2.71315667
116negative regulation of cell cycle arrest (GO:0071157)2.70256978
117regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.69330665
118rRNA methylation (GO:0031167)2.68249617
119snRNA metabolic process (GO:0016073)2.68155017
120viral transcription (GO:0019083)2.67615653
121transcription initiation from RNA polymerase I promoter (GO:0006361)2.66572592
122mRNA export from nucleus (GO:0006406)2.66483756
123regulation of action potential (GO:0098900)2.65977102
124DNA conformation change (GO:0071103)2.65782388
125positive regulation by host of viral transcription (GO:0043923)2.65600875
126DNA topological change (GO:0006265)2.65586967
127RNA export from nucleus (GO:0006405)2.65400924
128chromosome segregation (GO:0007059)2.64610061
129tRNA modification (GO:0006400)2.64603620
130cellular ketone body metabolic process (GO:0046950)2.64420410
131mitotic sister chromatid cohesion (GO:0007064)2.64377652
132gamma-aminobutyric acid transport (GO:0015812)2.63907919
133urinary tract smooth muscle contraction (GO:0014848)2.63311984
134negative regulation of histone methylation (GO:0031061)2.63242075
135histone mRNA catabolic process (GO:0071044)2.63212190
136chromatin assembly or disassembly (GO:0006333)2.62633094
137cellular response to exogenous dsRNA (GO:0071360)2.62044574
138axon ensheathment in central nervous system (GO:0032291)2.59379047
139central nervous system myelination (GO:0022010)2.59379047
140basic amino acid transport (GO:0015802)2.58698715
141mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.57476524
142mitochondrial respiratory chain complex I assembly (GO:0032981)2.57476524
143NADH dehydrogenase complex assembly (GO:0010257)2.57476524
144kynurenine metabolic process (GO:0070189)2.56818648
145cardiovascular system development (GO:0072358)2.56466699
146glycerophospholipid catabolic process (GO:0046475)2.56428243
147translational termination (GO:0006415)2.56060301
148cell migration in hindbrain (GO:0021535)2.55606996
149kidney morphogenesis (GO:0060993)2.54948628
150protein-cofactor linkage (GO:0018065)2.54231466
151detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.52463942
152peristalsis (GO:0030432)2.50476676
1533-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.49729707
154purine ribonucleoside bisphosphate metabolic process (GO:0034035)2.49729707
155NAD biosynthetic process (GO:0009435)2.49468327
156serine family amino acid catabolic process (GO:0009071)2.47197310
157cellular anion homeostasis (GO:0030002)2.47187678
158positive regulation of triglyceride biosynthetic process (GO:0010867)2.45298464
159protein complex biogenesis (GO:0070271)2.45034076
160positive regulation of defense response to virus by host (GO:0002230)2.44277620
161positive regulation of action potential (GO:0045760)2.43519682
162histone H3-K4 trimethylation (GO:0080182)2.43143284
163cell proliferation in forebrain (GO:0021846)2.42170868
164negative regulation of reactive oxygen species metabolic process (GO:2000378)2.41715666
165water-soluble vitamin biosynthetic process (GO:0042364)2.41625211
166negative regulation by host of viral transcription (GO:0043922)2.39796141
167indole-containing compound metabolic process (GO:0042430)2.39049535
168mitochondrial respiratory chain complex assembly (GO:0033108)2.38945614
169cell differentiation in spinal cord (GO:0021515)2.37678704
170reflex (GO:0060004)2.37149376
171negative regulation of sodium ion transport (GO:0010766)2.36694842
172regulation of telomere maintenance (GO:0032204)2.36649553
173somite development (GO:0061053)2.36599384
174epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.35449155
175DNA methylation (GO:0006306)2.35396147
176DNA alkylation (GO:0006305)2.35396147
177membrane depolarization during action potential (GO:0086010)2.32406400
178renal tubule morphogenesis (GO:0061333)2.31965652
179primary amino compound metabolic process (GO:1901160)2.31839427
180fucosylation (GO:0036065)2.31134308
181regulation of fatty acid beta-oxidation (GO:0031998)2.30344127
182positive regulation of mRNA catabolic process (GO:0061014)2.30183258
183ketone body metabolic process (GO:1902224)2.29998297
184regulation of mesoderm development (GO:2000380)2.26872635
185negative regulation of astrocyte differentiation (GO:0048712)2.26790543
186behavioral response to ethanol (GO:0048149)2.25995595
187amine catabolic process (GO:0009310)2.25755030
188cellular biogenic amine catabolic process (GO:0042402)2.25755030
189regulation of triglyceride biosynthetic process (GO:0010866)2.24827843
190pyrimidine ribonucleoside catabolic process (GO:0046133)2.24264859
191neuronal action potential propagation (GO:0019227)2.23363116
192mRNA splice site selection (GO:0006376)2.22677515
193hindbrain development (GO:0030902)2.22614455
194preassembly of GPI anchor in ER membrane (GO:0016254)2.22462768

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.72583512
2EZH2_22144423_ChIP-Seq_EOC_Human4.18279034
3* MYC_18555785_ChIP-Seq_MESCs_Mouse3.96630293
4E2F4_17652178_ChIP-ChIP_JURKAT_Human3.90007289
5FOXM1_23109430_ChIP-Seq_U2OS_Human3.79642591
6ZNF274_21170338_ChIP-Seq_K562_Hela3.67833996
7FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.21188596
8KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.98978515
9EST1_17652178_ChIP-ChIP_JURKAT_Human2.77425118
10MYC_19079543_ChIP-ChIP_MESCs_Mouse2.76831914
11* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.76562250
12EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.69193249
13CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human2.64087013
14DROSHA_22980978_ChIP-Seq_HELA_Human2.50164936
15* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.43177983
16EGR1_19374776_ChIP-ChIP_THP-1_Human2.37910621
17VDR_22108803_ChIP-Seq_LS180_Human2.34273384
18* JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.31548819
19* NELFA_20434984_ChIP-Seq_ESCs_Mouse2.30684093
20GABP_17652178_ChIP-ChIP_JURKAT_Human2.29907238
21KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.27857378
22E2F1_21310950_ChIP-Seq_MCF-7_Human2.21882746
23CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.17295742
24MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.17010145
25ELF1_17652178_ChIP-ChIP_JURKAT_Human2.16734737
26EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.16405762
27CREB1_15753290_ChIP-ChIP_HEK293T_Human2.15643622
28ETS1_20019798_ChIP-Seq_JURKAT_Human2.14546001
29HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.11513539
30VDR_23849224_ChIP-Seq_CD4+_Human2.09455187
31PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.03831562
32MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.99069929
33XRN2_22483619_ChIP-Seq_HELA_Human1.93892867
34FOXP3_21729870_ChIP-Seq_TREG_Human1.92955667
35NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.91825671
36REST_21632747_ChIP-Seq_MESCs_Mouse1.91438383
37MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.91249252
38AR_21572438_ChIP-Seq_LNCaP_Human1.89151684
39ELK1_19687146_ChIP-ChIP_HELA_Human1.88529008
40GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.85817319
41* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.84970925
42ERA_21632823_ChIP-Seq_H3396_Human1.84483572
43SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.79876651
44TP63_19390658_ChIP-ChIP_HaCaT_Human1.79644811
45PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.77995066
46FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.77857984
47NANOG_18555785_ChIP-Seq_MESCs_Mouse1.76996395
48NOTCH1_21737748_ChIP-Seq_TLL_Human1.76240913
49POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.75703339
50DCP1A_22483619_ChIP-Seq_HELA_Human1.75051079
51E2F1_18555785_ChIP-Seq_MESCs_Mouse1.75015368
52STAT6_21828071_ChIP-Seq_BEAS2B_Human1.74149064
53P68_20966046_ChIP-Seq_HELA_Human1.72228920
54YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.68792386
55EZH2_27294783_Chip-Seq_ESCs_Mouse1.66553317
56* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.63813726
57HOXB4_20404135_ChIP-ChIP_EML_Mouse1.63228943
58HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.59537510
59SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.59498947
60TTF2_22483619_ChIP-Seq_HELA_Human1.59149156
61AR_21909140_ChIP-Seq_LNCAP_Human1.59052466
62NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.58817343
63GABP_19822575_ChIP-Seq_HepG2_Human1.58301016
64CBX2_27304074_Chip-Seq_ESCs_Mouse1.53974300
65JARID2_20064375_ChIP-Seq_MESCs_Mouse1.53668741
66SUZ12_27294783_Chip-Seq_ESCs_Mouse1.51582346
67EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.51232188
68CTCF_27219007_Chip-Seq_Bcells_Human1.50838033
69PHF8_20622854_ChIP-Seq_HELA_Human1.50409251
70RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.50142538
71E2F1_20622854_ChIP-Seq_HELA_Human1.48993319
72TDRD3_21172665_ChIP-Seq_MCF-7_Human1.48667293
73THAP11_20581084_ChIP-Seq_MESCs_Mouse1.48420565
74SALL1_21062744_ChIP-ChIP_HESCs_Human1.46688826
75CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.45081530
76GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.44406897
77CIITA_25753668_ChIP-Seq_RAJI_Human1.43094761
78REST_18959480_ChIP-ChIP_MESCs_Mouse1.43030912
79HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.41447948
80* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.41410202
81ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.41209826
82MYC_22102868_ChIP-Seq_BL_Human1.41138225
83JARID2_20075857_ChIP-Seq_MESCs_Mouse1.40546333
84ERG_21242973_ChIP-ChIP_JURKAT_Human1.39986964
85VDR_21846776_ChIP-Seq_THP-1_Human1.39198493
86SRF_21415370_ChIP-Seq_HL-1_Mouse1.38610292
87POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.38473965
88E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.38024308
89POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.36195552
90YY1_22570637_ChIP-Seq_MALME-3M_Human1.36171216
91STAT3_1855785_ChIP-Seq_MESCs_Mouse1.35987765
92ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.35949138
93RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.34409557
94PADI4_21655091_ChIP-ChIP_MCF-7_Human1.34011397
95MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.33363007
96RNF2_27304074_Chip-Seq_ESCs_Mouse1.31553739
97SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.31078340
98YY1_21170310_ChIP-Seq_MESCs_Mouse1.29883672
99ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.29306377
100BCL6_27268052_Chip-Seq_Bcells_Human1.29031944
101KDM5A_27292631_Chip-Seq_BREAST_Human1.28454774
102RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.27896987
103ZFX_18555785_ChIP-Seq_MESCs_Mouse1.26232553
104RAC3_21632823_ChIP-Seq_H3396_Human1.25646499
105OCT4_19829295_ChIP-Seq_ESCs_Human1.25512200
106TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.23530710
107BMI1_23680149_ChIP-Seq_NPCS_Mouse1.23328327
108GBX2_23144817_ChIP-Seq_PC3_Human1.22232878
109CTBP1_25329375_ChIP-Seq_LNCAP_Human1.22018061
110EZH2_27304074_Chip-Seq_ESCs_Mouse1.21778265
111WDR5_24793694_ChIP-Seq_LNCAP_Human1.21104153
112SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.20961313
113TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.20540399
114GATA3_21878914_ChIP-Seq_MCF-7_Human1.20438059
115EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.20223266
116TP53_22573176_ChIP-Seq_HFKS_Human1.19868695
117TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.19256051
118POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.19256051
119IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.18923063
120RBPJ_22232070_ChIP-Seq_NCS_Mouse1.18558737
121ERG_20887958_ChIP-Seq_HPC-7_Mouse1.17417102
122FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.16416220
123SOX2_18555785_ChIP-Seq_MESCs_Mouse1.16333550
124TAF2_19829295_ChIP-Seq_ESCs_Human1.12563157
125ELF1_20517297_ChIP-Seq_JURKAT_Human1.12548093
126FOXP1_21924763_ChIP-Seq_HESCs_Human1.11999433
127MYC_19829295_ChIP-Seq_ESCs_Human1.11925590
128* SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.11574781
129P300_27268052_Chip-Seq_Bcells_Human1.10981526
130IKZF1_21737484_ChIP-ChIP_HCT116_Human1.10830656
131HOXB7_26014856_ChIP-Seq_BT474_Human1.10482415
132IGF1R_20145208_ChIP-Seq_DFB_Human1.10415635
133ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.10001260
134* OCT4_20526341_ChIP-Seq_ESCs_Human1.08974123
135BCOR_27268052_Chip-Seq_Bcells_Human1.08645054
136* SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.08580880
137TFEB_21752829_ChIP-Seq_HELA_Human1.08437641
138ER_23166858_ChIP-Seq_MCF-7_Human1.07374471
139E2F1_17053090_ChIP-ChIP_MCF-7_Human1.07341813
140KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.06448089
141KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.06448089
142KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.06448089
143CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.06001833
144EED_16625203_ChIP-ChIP_MESCs_Mouse1.05327718
145CTCF_20526341_ChIP-Seq_ESCs_Human1.05150671
146E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.04364518
147CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.04354227
148RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.04202378
149NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.03875910
150P53_21459846_ChIP-Seq_SAOS-2_Human1.03765577
151SA1_27219007_Chip-Seq_Bcells_Human1.03244677
152ETV2_25802403_ChIP-Seq_MESCs_Mouse1.03126605
153* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.02933876
154* MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.02744591
155SPI1_23547873_ChIP-Seq_NB4_Human1.02636335
156KLF4_18555785_ChIP-Seq_MESCs_Mouse1.02026575
157MYC_18940864_ChIP-ChIP_HL60_Human0.99783169
158ESR1_15608294_ChIP-ChIP_MCF-7_Human0.99564841
159EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.99323417
160RARB_24833708_ChIP-Seq_LIVER_Mouse0.98024051
161IRF1_19129219_ChIP-ChIP_H3396_Human0.96018053
162* MAF_26560356_Chip-Seq_TH2_Human0.95993381
163STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.94840123
164RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.93729079
165CTBP2_25329375_ChIP-Seq_LNCAP_Human0.93414841
166SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.93372752
167VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.93294483
168KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.92730773
169PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.91764341
170* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.91260733
171TET1_21451524_ChIP-Seq_MESCs_Mouse0.90575233
172CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.89823387
173NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.89166279
174SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.89075953
175TCF3_18692474_ChIP-Seq_MEFs_Mouse0.87808377
176CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.84926747
177CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.84788022
178* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.84524325
179FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.83925912
180PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.82715951
181* BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.81626675
182TCF3_18692474_ChIP-Seq_MESCs_Mouse0.81478044
183SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.80751279
184DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.80455503
185NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.80323487
186NANOG_21062744_ChIP-ChIP_HESCs_Human0.79627131
187MYB_26560356_Chip-Seq_TH1_Human0.78532288

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication4.89878739
2MP0003693_abnormal_embryo_hatching4.59765848
3MP0010094_abnormal_chromosome_stability4.28771652
4MP0003111_abnormal_nucleus_morphology3.70061069
5MP0004957_abnormal_blastocyst_morpholog3.58301840
6MP0003077_abnormal_cell_cycle3.42154604
7MP0008058_abnormal_DNA_repair3.35032783
8MP0008007_abnormal_cellular_replicative3.09553552
9MP0003136_yellow_coat_color2.67046158
10MP0008877_abnormal_DNA_methylation2.37436967
11MP0003123_paternal_imprinting2.23360846
12MP0001968_abnormal_touch/_nociception2.22811669
13MP0002653_abnormal_ependyma_morphology2.20836246
14MP0003786_premature_aging2.09708066
15MP0002396_abnormal_hematopoietic_system2.06056379
16MP0000350_abnormal_cell_proliferation2.04201846
17MP0003283_abnormal_digestive_organ1.99556111
18MP0010352_gastrointestinal_tract_polyps1.97600356
19MP0001730_embryonic_growth_arrest1.96451263
20MP0008932_abnormal_embryonic_tissue1.92373231
21MP0004808_abnormal_hematopoietic_stem1.91692136
22MP0005551_abnormal_eye_electrophysiolog1.91388175
23MP0001986_abnormal_taste_sensitivity1.85771704
24MP0003121_genomic_imprinting1.83271397
25MP0008872_abnormal_physiological_respon1.83141507
26MP0003787_abnormal_imprinting1.83119278
27MP0002938_white_spotting1.83004681
28MP0003763_abnormal_thymus_physiology1.81018191
29MP0008995_early_reproductive_senescence1.80050964
30MP0009745_abnormal_behavioral_response1.76951566
31MP0001672_abnormal_embryogenesis/_devel1.76083347
32MP0005380_embryogenesis_phenotype1.76083347
33MP0009046_muscle_twitch1.75923778
34MP0008875_abnormal_xenobiotic_pharmacok1.71689451
35MP0000490_abnormal_crypts_of1.69081724
36MP0001502_abnormal_circadian_rhythm1.68410517
37MP0000631_abnormal_neuroendocrine_gland1.65787884
38MP0002638_abnormal_pupillary_reflex1.65070890
39MP0003567_abnormal_fetal_cardiomyocyte1.60007433
40MP0002064_seizures1.59460119
41MP0001697_abnormal_embryo_size1.58846992
42MP0004147_increased_porphyrin_level1.58065367
43MP0001873_stomach_inflammation1.57982448
44MP0010307_abnormal_tumor_latency1.57105463
45MP0005645_abnormal_hypothalamus_physiol1.55979575
46MP0003195_calcinosis1.55688317
47MP0003984_embryonic_growth_retardation1.54047734
48MP0001485_abnormal_pinna_reflex1.54022253
49MP0009053_abnormal_anal_canal1.53707756
50MP0000566_synostosis1.52447263
51MP0002876_abnormal_thyroid_physiology1.52116445
52MP0002088_abnormal_embryonic_growth/wei1.51878233
53MP0009379_abnormal_foot_pigmentation1.50110703
54MP0003122_maternal_imprinting1.47951549
55MP0003646_muscle_fatigue1.47649804
56MP0000313_abnormal_cell_death1.46615447
57MP0003718_maternal_effect1.46407322
58MP0004043_abnormal_pH_regulation1.45487712
59MP0002736_abnormal_nociception_after1.42462642
60MP0002086_abnormal_extraembryonic_tissu1.40757580
61MP0004197_abnormal_fetal_growth/weight/1.39993145
62MP0002132_abnormal_respiratory_system1.35717396
63MP0002272_abnormal_nervous_system1.35129533
64MP0004885_abnormal_endolymph1.35056131
65MP0001501_abnormal_sleep_pattern1.34616132
66MP0001835_abnormal_antigen_presentation1.34338918
67MP0004130_abnormal_muscle_cell1.32443946
68MP0003635_abnormal_synaptic_transmissio1.31875137
69MP0004142_abnormal_muscle_tone1.31555818
70MP0002735_abnormal_chemical_nociception1.30875555
71MP0004742_abnormal_vestibular_system1.30773045
72MP0002080_prenatal_lethality1.30010547
73MP0002398_abnormal_bone_marrow1.29792324
74MP0002019_abnormal_tumor_incidence1.29459725
75MP0003890_abnormal_embryonic-extraembry1.27245977
76MP0003878_abnormal_ear_physiology1.26769805
77MP0005377_hearing/vestibular/ear_phenot1.26769805
78MP0002085_abnormal_embryonic_tissue1.25378225
79MP0003806_abnormal_nucleotide_metabolis1.25062160
80MP0002084_abnormal_developmental_patter1.24037228
81MP0002557_abnormal_social/conspecific_i1.22885482
82MP0005646_abnormal_pituitary_gland1.22675139
83MP0002572_abnormal_emotion/affect_behav1.22218733
84MP0000703_abnormal_thymus_morphology1.21320345
85MP0002063_abnormal_learning/memory/cond1.20392702
86MP0000569_abnormal_digit_pigmentation1.19318696
87MP0005397_hematopoietic_system_phenotyp1.19071873
88MP0001545_abnormal_hematopoietic_system1.19071873
89MP0005367_renal/urinary_system_phenotyp1.18912287
90MP0000516_abnormal_urinary_system1.18912287
91MP0000689_abnormal_spleen_morphology1.18847670
92MP0001486_abnormal_startle_reflex1.16424009
93MP0005671_abnormal_response_to1.16005172
94MP0002102_abnormal_ear_morphology1.15876592
95MP0002722_abnormal_immune_system1.15440589
96MP0009333_abnormal_splenocyte_physiolog1.15225639
97MP0002009_preneoplasia1.14045998
98MP0008961_abnormal_basal_metabolism1.12439786
99MP0003315_abnormal_perineum_morphology1.11907574
100MP0002089_abnormal_postnatal_growth/wei1.09873743
101MP0002822_catalepsy1.07872055
102MP0005423_abnormal_somatic_nervous1.07690177
103MP0006292_abnormal_olfactory_placode1.07438167
104MP0002733_abnormal_thermal_nociception1.06985965
105MP0002067_abnormal_sensory_capabilities1.06954473
106MP0002277_abnormal_respiratory_mucosa1.06385760
107MP0006072_abnormal_retinal_apoptosis1.06317129
108MP0001293_anophthalmia1.06176112
109MP0005360_urolithiasis1.05114103
110MP0002138_abnormal_hepatobiliary_system1.03061098
111MP0008789_abnormal_olfactory_epithelium1.02339083
112MP0000015_abnormal_ear_pigmentation1.02051138
113MP0001119_abnormal_female_reproductive1.01692887
114MP0003119_abnormal_digestive_system1.01551079
115MP0002210_abnormal_sex_determination1.00707030
116MP0005408_hypopigmentation0.99946539
117MP0002249_abnormal_larynx_morphology0.96541040
118MP0002429_abnormal_blood_cell0.96094384
119MP0001970_abnormal_pain_threshold0.96081723
120MP0003941_abnormal_skin_development0.95670554
121MP0002837_dystrophic_cardiac_calcinosis0.93702279
122MP0001944_abnormal_pancreas_morphology0.93532944
123MP0002006_tumorigenesis0.93205542
124MP0003186_abnormal_redox_activity0.93193013
125MP0001800_abnormal_humoral_immune0.91818194
126MP0000716_abnormal_immune_system0.91733619
127MP0002160_abnormal_reproductive_system0.90809677
128MP0002184_abnormal_innervation0.89405798
129MP0005448_abnormal_energy_balance0.89156000
130MP0001919_abnormal_reproductive_system0.89095617
131MP0004381_abnormal_hair_follicle0.88453485
132MP0005220_abnormal_exocrine_pancreas0.88302878
133MP0001145_abnormal_male_reproductive0.87703085
134MP0005386_behavior/neurological_phenoty0.87652005
135MP0004924_abnormal_behavior0.87652005
136MP0002693_abnormal_pancreas_physiology0.87429698
137MP0003698_abnormal_male_reproductive0.87342823
138MP0003938_abnormal_ear_development0.86867770
139MP0005075_abnormal_melanosome_morpholog0.86436504
140MP0001929_abnormal_gametogenesis0.86265088
141MP0005389_reproductive_system_phenotype0.86144289
142MP0009703_decreased_birth_body0.85375052
143MP0000955_abnormal_spinal_cord0.84355011
144MP0002420_abnormal_adaptive_immunity0.84173667
145MP0009278_abnormal_bone_marrow0.83846833
146MP0010329_abnormal_lipoprotein_level0.83764230
147MP0002166_altered_tumor_susceptibility0.83274208
148MP0000383_abnormal_hair_follicle0.83094059
149MP0001819_abnormal_immune_cell0.82817519
150MP0001188_hyperpigmentation0.82793043
151MP0000026_abnormal_inner_ear0.82059977
152MP0005076_abnormal_cell_differentiation0.81531938
153MP0000858_altered_metastatic_potential0.81189411
154MP0002111_abnormal_tail_morphology0.80486917
155MP0002452_abnormal_antigen_presenting0.80376351
156MP0005195_abnormal_posterior_eye0.80041709
157MP0002752_abnormal_somatic_nervous0.79776806
158MP0004145_abnormal_muscle_electrophysio0.79146248
159MP0002734_abnormal_mechanical_nocicepti0.78148071
160MP0000653_abnormal_sex_gland0.78029836
161MP0003943_abnormal_hepatobiliary_system0.77966429
162MP0005253_abnormal_eye_physiology0.77809638
163MP0002152_abnormal_brain_morphology0.77248753
164MP0005174_abnormal_tail_pigmentation0.76211466
165MP0005394_taste/olfaction_phenotype0.75616337
166MP0005499_abnormal_olfactory_system0.75616337
167MP0009672_abnormal_birth_weight0.74651003
168MP0000778_abnormal_nervous_system0.74634776
169MP0001915_intracranial_hemorrhage0.73814849
170MP0003861_abnormal_nervous_system0.73699805
171MP0004133_heterotaxia0.71927245
172MP0009697_abnormal_copulation0.71920349
173MP0005365_abnormal_bile_salt0.71418032
174MP0002928_abnormal_bile_duct0.70904771
175MP0004264_abnormal_extraembryonic_tissu0.70312832
176MP0002882_abnormal_neuron_morphology0.69529822
177MP0005384_cellular_phenotype0.69305514
178MP0002723_abnormal_immune_serum0.68422659
179MP0002877_abnormal_melanocyte_morpholog0.67809232
180MP0001186_pigmentation_phenotype0.67315288
181MP0010155_abnormal_intestine_physiology0.66196557
182MP0010030_abnormal_orbit_morphology0.66186781
183MP0002405_respiratory_system_inflammati0.65541741

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)6.09007098
2Chromsome breakage (HP:0040012)3.96625407
3Chromosomal breakage induced by crosslinking agents (HP:0003221)3.96545540
4Breast hypoplasia (HP:0003187)3.86855227
5Congenital stationary night blindness (HP:0007642)3.50240545
6Pancreatic cysts (HP:0001737)3.47633930
7Abnormal number of erythroid precursors (HP:0012131)3.37118447
8Abnormality of chromosome stability (HP:0003220)3.35413739
9Degeneration of anterior horn cells (HP:0002398)3.23329532
10Abnormality of the anterior horn cell (HP:0006802)3.23329532
11Molar tooth sign on MRI (HP:0002419)3.21254885
12Abnormality of midbrain morphology (HP:0002418)3.21254885
13Patellar aplasia (HP:0006443)3.18874689
14Clumsiness (HP:0002312)3.17316623
15Carpal bone hypoplasia (HP:0001498)3.13925999
16Nephronophthisis (HP:0000090)3.11499983
17Meckel diverticulum (HP:0002245)3.06396833
18Medulloblastoma (HP:0002885)3.05300387
19Abnormality of cells of the erythroid lineage (HP:0012130)3.04774677
20Abnormality of the ileum (HP:0001549)3.03465272
21Genetic anticipation (HP:0003743)3.03214427
22Aplasia/Hypoplasia of the uvula (HP:0010293)3.03084276
23Agnosia (HP:0010524)3.02910363
24Ectopic kidney (HP:0000086)3.02026897
25Type II lissencephaly (HP:0007260)3.01362396
26Abnormality of the preputium (HP:0100587)3.01143492
27Abnormality of the labia minora (HP:0012880)3.00774027
28Aplastic anemia (HP:0001915)2.98927726
29Myelodysplasia (HP:0002863)2.98370327
30Aplasia/Hypoplasia of the patella (HP:0006498)2.97018092
31Protruding tongue (HP:0010808)2.94357885
32Pancreatic fibrosis (HP:0100732)2.92885029
3311 pairs of ribs (HP:0000878)2.84481510
34Intestinal fistula (HP:0100819)2.83296583
35True hermaphroditism (HP:0010459)2.81938309
36Amaurosis fugax (HP:0100576)2.79072482
37Rectal fistula (HP:0100590)2.78372442
38Rectovaginal fistula (HP:0000143)2.78372442
39Absent thumb (HP:0009777)2.75994717
40Pendular nystagmus (HP:0012043)2.75757664
41Colon cancer (HP:0003003)2.74572324
42Abnormality of cochlea (HP:0000375)2.71417711
43Ependymoma (HP:0002888)2.69417287
44Large for gestational age (HP:0001520)2.68430172
45Cystic liver disease (HP:0006706)2.62165615
46Impulsivity (HP:0100710)2.60805452
47Partial agenesis of the corpus callosum (HP:0001338)2.59080380
48Concave nail (HP:0001598)2.58645728
49Rib fusion (HP:0000902)2.57648273
50Attenuation of retinal blood vessels (HP:0007843)2.56097154
51Duplicated collecting system (HP:0000081)2.52647489
52Selective tooth agenesis (HP:0001592)2.52536565
53Reticulocytopenia (HP:0001896)2.52182905
54Bone marrow hypocellularity (HP:0005528)2.45173656
55Abnormality of the renal medulla (HP:0100957)2.45063521
56Hyperventilation (HP:0002883)2.41622005
57Absent radius (HP:0003974)2.36531301
58Hypoplasia of the pons (HP:0012110)2.33510734
59Polydipsia (HP:0001959)2.32580162
60Abnormal drinking behavior (HP:0030082)2.32580162
61Duodenal stenosis (HP:0100867)2.32198122
62Small intestinal stenosis (HP:0012848)2.32198122
63Abnormality of the renal collecting system (HP:0004742)2.31326072
64Asplenia (HP:0001746)2.31123277
65Chronic hepatic failure (HP:0100626)2.29504017
66Optic nerve coloboma (HP:0000588)2.27812346
67Rhabdomyosarcoma (HP:0002859)2.27717684
68Inability to walk (HP:0002540)2.27555818
69Shawl scrotum (HP:0000049)2.26918962
70Thrombocytosis (HP:0001894)2.25094310
71Abnormality of the carotid arteries (HP:0005344)2.24749625
72Abnormality of the pons (HP:0007361)2.24258433
73Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.22745643
74Clubbing of toes (HP:0100760)2.21613869
75Progressive cerebellar ataxia (HP:0002073)2.18861838
76Deep philtrum (HP:0002002)2.18781154
77Vaginal fistula (HP:0004320)2.18448232
78Stenosis of the external auditory canal (HP:0000402)2.17766078
79Morphological abnormality of the inner ear (HP:0011390)2.17653010
80Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.17185430
81Cutaneous melanoma (HP:0012056)2.15486828
82Supernumerary spleens (HP:0009799)2.14863176
83Nephroblastoma (Wilms tumor) (HP:0002667)2.14014794
84Aplasia involving forearm bones (HP:0009822)2.13826991
85Absent forearm bone (HP:0003953)2.13826991
86Sloping forehead (HP:0000340)2.13084817
87Cerebellar dysplasia (HP:0007033)2.12792689
88Panhypogammaglobulinemia (HP:0003139)2.11653899
89Volvulus (HP:0002580)2.11090315
90Aplasia/hypoplasia of the humerus (HP:0006507)2.11033944
91Decreased circulating renin level (HP:0003351)2.11024544
92Progressive inability to walk (HP:0002505)2.10602218
93Anal stenosis (HP:0002025)2.09763555
94Oral leukoplakia (HP:0002745)2.08510032
95Abolished electroretinogram (ERG) (HP:0000550)2.07605465
96Intestinal atresia (HP:0011100)2.07493694
97Acute myeloid leukemia (HP:0004808)2.07006119
98Congenital, generalized hypertrichosis (HP:0004540)2.06806941
99Aplasia/Hypoplasia of the spleen (HP:0010451)2.06080714
100Premature graying of hair (HP:0002216)2.05459492
101Supernumerary bones of the axial skeleton (HP:0009144)2.05200210
102Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.04501606
103Hypoplasia of the capital femoral epiphysis (HP:0003090)2.04065535
104Bilateral microphthalmos (HP:0007633)2.03698362
105Broad-based gait (HP:0002136)2.03672475
106Abnormal biliary tract physiology (HP:0012439)2.02417392
107Bile duct proliferation (HP:0001408)2.02417392
108Short thumb (HP:0009778)2.02266584
109Tubular atrophy (HP:0000092)2.01791483
110Lymphoma (HP:0002665)2.00118544
111Abnormality of the duodenum (HP:0002246)1.99937248
112Lissencephaly (HP:0001339)1.99876782
113Basal cell carcinoma (HP:0002671)1.99393411
114Short humerus (HP:0005792)1.97098470
115Neoplasm of the oral cavity (HP:0100649)1.96822854
116Bulbous nose (HP:0000414)1.96081806
117Abnormality of the prostate (HP:0008775)1.95799727
118Embryonal renal neoplasm (HP:0011794)1.95746240
119Abnormality of the fingertips (HP:0001211)1.95061348
120Triphalangeal thumb (HP:0001199)1.94250886
121Abnormality of the renal cortex (HP:0011035)1.93213144
122Focal motor seizures (HP:0011153)1.92357047
123Missing ribs (HP:0000921)1.90488033
124Sclerocornea (HP:0000647)1.90224922
125Abnormality of abdominal situs (HP:0011620)1.89846181
126Abdominal situs inversus (HP:0003363)1.89846181
127Febrile seizures (HP:0002373)1.89760206
128Abnormal biliary tract morphology (HP:0012440)1.88785398
129Severe muscular hypotonia (HP:0006829)1.86764955
130Abnormal lung lobation (HP:0002101)1.86608880
131Gaze-evoked nystagmus (HP:0000640)1.86184056
132Microretrognathia (HP:0000308)1.86163511
133Slender long bone (HP:0003100)1.86130535
134Breast aplasia (HP:0100783)1.84935121
135Epileptic encephalopathy (HP:0200134)1.84828112
136Syringomyelia (HP:0003396)1.83609535
137Spinal cord lesions (HP:0100561)1.83609535
138Lip pit (HP:0100267)1.82190343
139Conical tooth (HP:0000698)1.80801240
140Biliary tract neoplasm (HP:0100574)1.80256977
141Anencephaly (HP:0002323)1.80237794
142Horseshoe kidney (HP:0000085)1.79570378
143Abnormal number of incisors (HP:0011064)1.79497737
144T lymphocytopenia (HP:0005403)1.78977280
145Tracheoesophageal fistula (HP:0002575)1.78103903
146Progressive microcephaly (HP:0000253)1.78089275
147Acute lymphatic leukemia (HP:0006721)1.77660977
148Retinal dysplasia (HP:0007973)1.77649078
149Prostate neoplasm (HP:0100787)1.76031350
150Hypoplasia of the radius (HP:0002984)1.75656943
151Cellular immunodeficiency (HP:0005374)1.74713211
152Spinal muscular atrophy (HP:0007269)1.74541139
153Hypoplasia of the ulna (HP:0003022)1.74312474
154Type I transferrin isoform profile (HP:0003642)1.73931987
155Male pseudohermaphroditism (HP:0000037)1.73803097
156Bony spicule pigmentary retinopathy (HP:0007737)1.72777323
157Neoplasm of the pancreas (HP:0002894)1.70801655
158Abnormality of DNA repair (HP:0003254)1.69347691
159Hemiparesis (HP:0001269)1.69307097
160Anophthalmia (HP:0000528)1.68073856
161Neoplasm of the adrenal cortex (HP:0100641)1.66828784
162Prominent nose (HP:0000448)1.65886512
163Cafe-au-lait spot (HP:0000957)1.65732406
164Furrowed tongue (HP:0000221)1.65574519
165Focal seizures (HP:0007359)1.65565110
166Osteomalacia (HP:0002749)1.65094945
167Decreased central vision (HP:0007663)1.64831338
168Hyperglycinuria (HP:0003108)1.63454251
169Combined immunodeficiency (HP:0005387)1.63219046
170Abnormality of T cell number (HP:0011839)1.62800595
171Abnormality of the pubic bones (HP:0003172)1.62760835
172Polyuria (HP:0000103)1.62570975
173Bronchomalacia (HP:0002780)1.61950389
174Septo-optic dysplasia (HP:0100842)1.61487657
175Status epilepticus (HP:0002133)1.59046973
176Ketosis (HP:0001946)1.58915904
177Abnormal rod and cone electroretinograms (HP:0008323)1.58402117
178Absent rod-and cone-mediated responses on ERG (HP:0007688)1.58363592
179Impaired smooth pursuit (HP:0007772)1.57442049
180Abnormal delayed hypersensitivity skin test (HP:0002963)1.57372285
181Enlarged kidneys (HP:0000105)1.56612699
182Tachypnea (HP:0002789)1.54629986
183Postaxial foot polydactyly (HP:0001830)1.53587875

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NME23.54341507
2WEE13.30956762
3CDC73.16169879
4BRSK23.09552479
5SRPK13.02817275
6STK162.90846160
7WNK42.88007438
8PASK2.86132287
9BUB12.57052577
10SIK22.53676874
11BMPR1B2.43986916
12MKNK12.35339455
13TRIB32.31128780
14EIF2AK12.25684138
15PLK42.25076013
16MKNK22.10007904
17CDK122.08246638
18ZAK2.06052419
19ADRBK22.04272346
20TSSK61.99315575
21FGFR21.99147081
22MAP2K61.97999710
23EPHA21.96804464
24AKT31.94155011
25PLK31.90155907
26CAMK1D1.89451827
27TAOK31.86260837
28NEK21.84865587
29MAPK151.79813462
30INSRR1.78911181
31VRK11.78300520
32PLK11.76655413
33TTK1.74879723
34ATR1.70572078
35GRK11.65390136
36CDK71.57997086
37TYRO31.56096171
38ACVR1B1.54708769
39CAMKK11.52461339
40PIK3CA1.47178736
41MAPK131.46708010
42BRSK11.45231521
43DAPK21.43151120
44EIF2AK31.42744772
45TAF11.42699790
46EIF2AK21.41751763
47NEK61.41287412
48BRD41.41204905
49AURKB1.38513056
50RPS6KB21.36307643
51FLT31.30060649
52STK41.29709650
53NEK11.27827956
54TLK11.23634141
55CHEK11.20097823
56STK101.18617590
57CHEK21.18514907
58MAP3K141.18154157
59PIM11.16190171
60TXK1.14432807
61VRK21.10078238
62MAP2K21.08353010
63CAMK1G1.06431641
64IRAK41.06380872
65CDK41.05404326
66PINK11.05061399
67MAP2K31.03946456
68NEK91.03176512
69DYRK21.01311796
70CLK11.01249600
71TGFBR11.00601734
72MAP4K11.00346897
73NTRK20.99306495
74NME10.98262570
75ATM0.97802811
76MAPK110.97661672
77STK110.96561412
78STK38L0.95454121
79TNK20.95332526
80CHUK0.95303461
81YES10.91002391
82NUAK10.89621368
83MAP3K80.87705109
84AURKA0.87307666
85NTRK30.87236090
86GRK60.86588966
87ERBB30.84769266
88MAPKAPK50.84406673
89CAMKK20.84211386
90STK390.84054139
91PRKCQ0.84020154
92STK240.83531779
93CDK20.82641059
94ITK0.80236218
95TEC0.80184679
96TAOK20.72467157
97WNK10.71128146
98MAP3K70.71051974
99IKBKB0.70628849
100OXSR10.69588331
101CDK80.67987292
102RPS6KA40.66735265
103PRKCG0.66420372
104ALK0.66282253
105CASK0.65368102
106CSNK2A10.63127143
107SGK4940.62880236
108SGK2230.62880236
109PRKAA10.62750586
110MARK20.62514040
111JAK30.62042009
112STK30.61945840
113SYK0.61357477
114MARK30.60994268
115CAMK10.60471826
116PRKCH0.59942345
117RPS6KB10.59024299
118ICK0.58499842
119MAP4K20.58434295
120DYRK1A0.58388979
121CSNK2A20.58362681
122MAPKAPK30.58094298
123CAMK40.57261882
124MAPK120.56839934
125IRAK30.56216420
126DYRK30.55547133
127MAP3K110.55474921
128CDK10.55177459
129HIPK20.54673478
130CDK60.54447365
131SGK20.51902286
132SMG10.51864982
133MAP3K100.51655549
134MELK0.51169317
135PRKCZ0.51130467
136ADRBK10.50753203
137EEF2K0.49859358
138ERBB20.48321313
139MAP2K40.48080431
140UHMK10.47969646
141MST40.47548683
142CCNB10.47534780
143PRKAA20.46905367
144MAP3K30.45691615
145MAP3K40.45539726
146SGK10.44062263
147PKN20.44026396
148CSNK1D0.43936714
149PAK40.43470743
150PRKCI0.43433924
151PIK3CG0.42930073
152BTK0.42546208
153KIT0.42182853
154PTK60.42126940
155RPS6KA50.41957765
156CDK30.40996893
157PIM20.40432989
158SIK30.40202350
159RPS6KA60.39810368
160RPS6KC10.39471816
161RPS6KL10.39471816
162ZAP700.37920432
163MAPK140.34584501
164FGFR30.34411508
165FRK0.34118925
166BRAF0.32881970
167AKT10.31314189
168PRKDC0.29601493
169NLK0.28680178

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.65805233
2Mismatch repair_Homo sapiens_hsa034304.39617954
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.85872272
4alpha-Linolenic acid metabolism_Homo sapiens_hsa005923.40193998
5Linoleic acid metabolism_Homo sapiens_hsa005913.13848387
6RNA polymerase_Homo sapiens_hsa030203.09518172
7Homologous recombination_Homo sapiens_hsa034403.06574827
8Base excision repair_Homo sapiens_hsa034102.99494874
9Spliceosome_Homo sapiens_hsa030402.95375250
10One carbon pool by folate_Homo sapiens_hsa006702.95256462
11RNA transport_Homo sapiens_hsa030132.92033132
12Nitrogen metabolism_Homo sapiens_hsa009102.69220237
13Nucleotide excision repair_Homo sapiens_hsa034202.66578761
14Cell cycle_Homo sapiens_hsa041102.66341518
15Fanconi anemia pathway_Homo sapiens_hsa034602.58997757
16Non-homologous end-joining_Homo sapiens_hsa034502.48315198
17Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.38584032
18Maturity onset diabetes of the young_Homo sapiens_hsa049502.32760462
19Ribosome_Homo sapiens_hsa030102.30756195
20Proteasome_Homo sapiens_hsa030502.23762432
21Pyrimidine metabolism_Homo sapiens_hsa002402.21732164
22Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.13500036
23Nicotine addiction_Homo sapiens_hsa050332.13446742
24Phototransduction_Homo sapiens_hsa047442.05881646
25RNA degradation_Homo sapiens_hsa030181.97048307
26Ether lipid metabolism_Homo sapiens_hsa005651.96747220
27mRNA surveillance pathway_Homo sapiens_hsa030151.95056009
28Basal transcription factors_Homo sapiens_hsa030221.93567274
29Butanoate metabolism_Homo sapiens_hsa006501.88772310
30Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.83281068
31p53 signaling pathway_Homo sapiens_hsa041151.68368443
32ABC transporters_Homo sapiens_hsa020101.67223584
33Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.65716285
34Taste transduction_Homo sapiens_hsa047421.56120137
35Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.48767483
36Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.40355950
37Sulfur relay system_Homo sapiens_hsa041221.36338973
38Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.32794761
39Purine metabolism_Homo sapiens_hsa002301.29575692
40Herpes simplex infection_Homo sapiens_hsa051681.27406151
41Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.26347378
42Epstein-Barr virus infection_Homo sapiens_hsa051691.25502752
43Systemic lupus erythematosus_Homo sapiens_hsa053221.19039676
44Antigen processing and presentation_Homo sapiens_hsa046121.15633479
45Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.12197634
46Insulin secretion_Homo sapiens_hsa049111.11726534
47Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.11347524
48Tryptophan metabolism_Homo sapiens_hsa003801.11042276
49Primary immunodeficiency_Homo sapiens_hsa053401.07625363
50Glutamatergic synapse_Homo sapiens_hsa047241.06661387
51Selenocompound metabolism_Homo sapiens_hsa004501.06257335
52Viral carcinogenesis_Homo sapiens_hsa052031.06016642
53Glycerolipid metabolism_Homo sapiens_hsa005611.04436267
54Glycerophospholipid metabolism_Homo sapiens_hsa005641.03869422
55Morphine addiction_Homo sapiens_hsa050321.03197797
56Ovarian steroidogenesis_Homo sapiens_hsa049131.00193247
57Circadian entrainment_Homo sapiens_hsa047130.94899566
58Thyroid cancer_Homo sapiens_hsa052160.93822979
59Calcium signaling pathway_Homo sapiens_hsa040200.92014783
60Fat digestion and absorption_Homo sapiens_hsa049750.90890408
61NF-kappa B signaling pathway_Homo sapiens_hsa040640.88478196
62Vitamin digestion and absorption_Homo sapiens_hsa049770.87399756
63Olfactory transduction_Homo sapiens_hsa047400.86288857
64Legionellosis_Homo sapiens_hsa051340.84551560
65Oxidative phosphorylation_Homo sapiens_hsa001900.84400596
66Histidine metabolism_Homo sapiens_hsa003400.80924320
67Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.80188971
68Measles_Homo sapiens_hsa051620.80107964
69Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.79715635
70Vascular smooth muscle contraction_Homo sapiens_hsa042700.79606436
71Transcriptional misregulation in cancer_Homo sapiens_hsa052020.79154664
72Aldosterone synthesis and secretion_Homo sapiens_hsa049250.78922032
73Cardiac muscle contraction_Homo sapiens_hsa042600.78178902
74Cholinergic synapse_Homo sapiens_hsa047250.76616819
75Carbohydrate digestion and absorption_Homo sapiens_hsa049730.75544259
76Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.75074183
77HTLV-I infection_Homo sapiens_hsa051660.74322621
78MicroRNAs in cancer_Homo sapiens_hsa052060.73372505
79Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.71306548
80Protein export_Homo sapiens_hsa030600.70016077
81Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.69344564
82Drug metabolism - other enzymes_Homo sapiens_hsa009830.68733470
83Oxytocin signaling pathway_Homo sapiens_hsa049210.68534048
84Serotonergic synapse_Homo sapiens_hsa047260.67134670
85Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.66669910
86Parkinsons disease_Homo sapiens_hsa050120.65395584
87Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.64158376
88Influenza A_Homo sapiens_hsa051640.64085617
89Cocaine addiction_Homo sapiens_hsa050300.62411947
90Fatty acid biosynthesis_Homo sapiens_hsa000610.60965077
91MAPK signaling pathway_Homo sapiens_hsa040100.60822041
92Chemical carcinogenesis_Homo sapiens_hsa052040.60703083
93Allograft rejection_Homo sapiens_hsa053300.60424039
94Amphetamine addiction_Homo sapiens_hsa050310.60400953
95Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.59904276
96Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.59712488
97Intestinal immune network for IgA production_Homo sapiens_hsa046720.59381095
98GABAergic synapse_Homo sapiens_hsa047270.58525535
99Cysteine and methionine metabolism_Homo sapiens_hsa002700.57666675
100Small cell lung cancer_Homo sapiens_hsa052220.57646469
101Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.56426086
102RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.56400520
103Caffeine metabolism_Homo sapiens_hsa002320.56362177
104Oocyte meiosis_Homo sapiens_hsa041140.55125606
105Hematopoietic cell lineage_Homo sapiens_hsa046400.54002880
106Type II diabetes mellitus_Homo sapiens_hsa049300.53875138
107Graft-versus-host disease_Homo sapiens_hsa053320.53824576
108Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.53661027
109Vitamin B6 metabolism_Homo sapiens_hsa007500.51865268
110Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.51214247
111Dopaminergic synapse_Homo sapiens_hsa047280.50303998
112Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.49770490
113Apoptosis_Homo sapiens_hsa042100.47685518
114Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.47289879
115Huntingtons disease_Homo sapiens_hsa050160.46703627
116Notch signaling pathway_Homo sapiens_hsa043300.46434214
117Longevity regulating pathway - mammal_Homo sapiens_hsa042110.45772421
118Dorso-ventral axis formation_Homo sapiens_hsa043200.45653076
119Steroid hormone biosynthesis_Homo sapiens_hsa001400.45048958
120VEGF signaling pathway_Homo sapiens_hsa043700.43988050
121NOD-like receptor signaling pathway_Homo sapiens_hsa046210.43581962
122Gastric acid secretion_Homo sapiens_hsa049710.43202034
123Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.42613261
124Hepatitis B_Homo sapiens_hsa051610.42481088
125Salivary secretion_Homo sapiens_hsa049700.40851514
126Hedgehog signaling pathway_Homo sapiens_hsa043400.40606910
127TGF-beta signaling pathway_Homo sapiens_hsa043500.40601926
128Choline metabolism in cancer_Homo sapiens_hsa052310.40275430
129N-Glycan biosynthesis_Homo sapiens_hsa005100.40263804
130Long-term depression_Homo sapiens_hsa047300.39929295
131Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.38713278
132Jak-STAT signaling pathway_Homo sapiens_hsa046300.38342854
133Leishmaniasis_Homo sapiens_hsa051400.38306262
134Biosynthesis of amino acids_Homo sapiens_hsa012300.38183925
135Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.37955004
136Colorectal cancer_Homo sapiens_hsa052100.37362125
137Acute myeloid leukemia_Homo sapiens_hsa052210.37298272
138Peroxisome_Homo sapiens_hsa041460.36289282
139Fructose and mannose metabolism_Homo sapiens_hsa000510.36248461
140T cell receptor signaling pathway_Homo sapiens_hsa046600.35283479
141Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.35144459
142Autoimmune thyroid disease_Homo sapiens_hsa053200.34413754
143Cyanoamino acid metabolism_Homo sapiens_hsa004600.32940329
144Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.32350114
145FoxO signaling pathway_Homo sapiens_hsa040680.32076138
146B cell receptor signaling pathway_Homo sapiens_hsa046620.31748690
147Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.29769855
148Glutathione metabolism_Homo sapiens_hsa004800.29478612
149Hippo signaling pathway_Homo sapiens_hsa043900.28588949
150Pathways in cancer_Homo sapiens_hsa052000.28579472
151Pentose phosphate pathway_Homo sapiens_hsa000300.28410863
152Arachidonic acid metabolism_Homo sapiens_hsa005900.27864794
153Basal cell carcinoma_Homo sapiens_hsa052170.27803818
154Alcoholism_Homo sapiens_hsa050340.27652024
155Viral myocarditis_Homo sapiens_hsa054160.27553047
156HIF-1 signaling pathway_Homo sapiens_hsa040660.26932359
157Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.25659528
158Adherens junction_Homo sapiens_hsa045200.25247858
159Prostate cancer_Homo sapiens_hsa052150.25004268
160Shigellosis_Homo sapiens_hsa051310.23687877
161Folate biosynthesis_Homo sapiens_hsa007900.21830765
162Lysine degradation_Homo sapiens_hsa003100.20956293
163Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.20894703
164Non-small cell lung cancer_Homo sapiens_hsa052230.19927242
165Chronic myeloid leukemia_Homo sapiens_hsa052200.19429196
166Leukocyte transendothelial migration_Homo sapiens_hsa046700.18534844
167Asthma_Homo sapiens_hsa053100.17254508
168Endometrial cancer_Homo sapiens_hsa052130.17118920
169Type I diabetes mellitus_Homo sapiens_hsa049400.16927064

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »