ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	DNA deamination (GO:0045006)	5.65713120
2	behavioral response to nicotine (GO:0035095)	5.56952614
3	response to pheromone (GO:0019236)	5.44491160
4	fucose catabolic process (GO:0019317)	4.36129643
5	L-fucose metabolic process (GO:0042354)	4.36129643
6	L-fucose catabolic process (GO:0042355)	4.36129643
7	protein polyglutamylation (GO:0018095)	4.14019323
8	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.94595822
9	protein complex biogenesis (GO:0070271)	3.80581468
10	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.66641921
11	NADH dehydrogenase complex assembly (GO:0010257)	3.66641921
12	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.66641921
13	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	3.58351418
14	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	3.58131443
15	ubiquinone biosynthetic process (GO:0006744)	3.56876805
16	mitochondrial respiratory chain complex assembly (GO:0033108)	3.56635716
17	cytidine deamination (GO:0009972)	3.54798778
18	cytidine metabolic process (GO:0046087)	3.54798778
19	cytidine catabolic process (GO:0006216)	3.54798778
20	respiratory chain complex IV assembly (GO:0008535)	3.52680171
21	axoneme assembly (GO:0035082)	3.52399659
22	cornea development in camera-type eye (GO:0061303)	3.51507659
23	negative regulation of telomere maintenance (GO:0032205)	3.49700015
24	regulation of cilium movement (GO:0003352)	3.49632296
25	platelet dense granule organization (GO:0060155)	3.47286253
26	piRNA metabolic process (GO:0034587)	3.41563465
27	epithelial cilium movement (GO:0003351)	3.38682834
28	nonmotile primary cilium assembly (GO:0035058)	3.38317477
29	protein-cofactor linkage (GO:0018065)	3.37744011
30	water-soluble vitamin biosynthetic process (GO:0042364)	3.33582748
31	preassembly of GPI anchor in ER membrane (GO:0016254)	3.31614347
32	ubiquinone metabolic process (GO:0006743)	3.29494679
33	cytochrome complex assembly (GO:0017004)	3.19759564
34	pyrimidine ribonucleoside catabolic process (GO:0046133)	3.12988146
35	indolalkylamine metabolic process (GO:0006586)	3.10888320
36	indole-containing compound catabolic process (GO:0042436)	3.06289654
37	indolalkylamine catabolic process (GO:0046218)	3.06289654
38	tryptophan catabolic process (GO:0006569)	3.06289654
39	synaptic transmission, cholinergic (GO:0007271)	3.03875331
40	ATP synthesis coupled proton transport (GO:0015986)	3.03481667
41	energy coupled proton transport, down electrochemical gradient (GO:0015985)	3.03481667
42	cellular ketone body metabolic process (GO:0046950)	3.02311946
43	negative regulation of mast cell activation (GO:0033004)	3.02193172
44	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	3.00304512
45	adaptation of signaling pathway (GO:0023058)	2.99456350
46	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	2.97822954
47	S-adenosylmethionine metabolic process (GO:0046500)	2.97586473
48	pyrimidine nucleobase catabolic process (GO:0006208)	2.97478865
49	kidney morphogenesis (GO:0060993)	2.97143735
50	regulation of microtubule-based movement (GO:0060632)	2.91669925
51	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	2.89889133
52	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	2.89889133
53	kynurenine metabolic process (GO:0070189)	2.89855278
54	tryptophan metabolic process (GO:0006568)	2.87023928
55	glycerophospholipid catabolic process (GO:0046475)	2.86566314
56	retinal cone cell development (GO:0046549)	2.84791035
57	protein neddylation (GO:0045116)	2.84773307
58	neural tube formation (GO:0001841)	2.81907558
59	quinone biosynthetic process (GO:1901663)	2.80901001
60	GPI anchor metabolic process (GO:0006505)	2.80506087
61	L-methionine salvage (GO:0071267)	2.79680403
62	L-methionine biosynthetic process (GO:0071265)	2.79680403
63	amino acid salvage (GO:0043102)	2.79680403
64	mannosylation (GO:0097502)	2.78376137
65	detection of light stimulus involved in sensory perception (GO:0050962)	2.77612559
66	detection of light stimulus involved in visual perception (GO:0050908)	2.77612559
67	cilium morphogenesis (GO:0060271)	2.76903147
68	nucleobase catabolic process (GO:0046113)	2.76163752
69	DNA methylation involved in gamete generation (GO:0043046)	2.75775024
70	ketone body metabolic process (GO:1902224)	2.75450447
71	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	2.73704180
72	photoreceptor cell development (GO:0042461)	2.72152703
73	negative regulation of synaptic transmission, GABAergic (GO:0032229)	2.71265722
74	regulation of nuclear cell cycle DNA replication (GO:0033262)	2.70957780
75	regulation of action potential (GO:0098900)	2.70745111
76	protein localization to cilium (GO:0061512)	2.65131656
77	peptidyl-histidine modification (GO:0018202)	2.64746414
78	cilium movement (GO:0003341)	2.63228329
79	somite development (GO:0061053)	2.63214111
80	parturition (GO:0007567)	2.62845238
81	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	2.62799724
82	intraciliary transport (GO:0042073)	2.61714876
83	pseudouridine synthesis (GO:0001522)	2.60546714
84	positive regulation of fatty acid transport (GO:2000193)	2.60235177
85	maturation of 5.8S rRNA (GO:0000460)	2.57460949
86	replication fork processing (GO:0031297)	2.57419465
87	cilium organization (GO:0044782)	2.55368497
88	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	2.54706810
89	DNA demethylation (GO:0080111)	2.54413688
90	positive regulation of prostaglandin secretion (GO:0032308)	2.54008242
91	cell proliferation in forebrain (GO:0021846)	2.53932912
92	tRNA processing (GO:0008033)	2.48438435
93	cilium assembly (GO:0042384)	2.45906023
94	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	2.43622327
95	neuronal action potential propagation (GO:0019227)	2.41687261
96	head development (GO:0060322)	2.41207508
97	neuronal action potential (GO:0019228)	2.40172780
98	negative regulation of transcription regulatory region DNA binding (GO:2000678)	2.39868989
99	auditory receptor cell stereocilium organization (GO:0060088)	2.39697617
100	behavioral response to ethanol (GO:0048149)	2.39045501

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ZNF274_21170338_ChIP-Seq_K562_Hela	4.21284809
2	VDR_22108803_ChIP-Seq_LS180_Human	3.31279163
3	EZH2_22144423_ChIP-Seq_EOC_Human	3.27081850
4	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.57906082
5	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.53747103
6	GBX2_23144817_ChIP-Seq_PC3_Human	2.46030008
7	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.36614827
8	IGF1R_20145208_ChIP-Seq_DFB_Human	2.30052248
9	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.26580968
10	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.17260867
11	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.08399966
12	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	2.03923645
13	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.02428294
14	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.02329709
15	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.02058398
16	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.01918146
17	IRF1_19129219_ChIP-ChIP_H3396_Human	2.00511998
18	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.94851262
19	EWS_26573619_Chip-Seq_HEK293_Human	1.94728409
20	FUS_26573619_Chip-Seq_HEK293_Human	1.91865912
21	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.84682333
22	TP53_22573176_ChIP-Seq_HFKS_Human	1.76901604
23	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.76210150
24	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.76124104
25	P300_19829295_ChIP-Seq_ESCs_Human	1.74612013
26	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.72170292
27	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.70392193
28	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.68964548
29	MYC_18940864_ChIP-ChIP_HL60_Human	1.66875632
30	ER_23166858_ChIP-Seq_MCF-7_Human	1.62496763
31	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.58227042
32	TAF15_26573619_Chip-Seq_HEK293_Human	1.56291822
33	CBP_20019798_ChIP-Seq_JUKART_Human	1.47897250
34	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.47897250
35	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.42175293
36	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.41831317
37	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.40271199
38	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.40196356
39	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.39835641
40	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.39590993
41	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.38765490
42	VDR_23849224_ChIP-Seq_CD4+_Human	1.37776469
43	REST_21632747_ChIP-Seq_MESCs_Mouse	1.36512136
44	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.35872460
45	BCAT_22108803_ChIP-Seq_LS180_Human	1.32785561
46	NANOG_19829295_ChIP-Seq_ESCs_Human	1.32344975
47	SOX2_19829295_ChIP-Seq_ESCs_Human	1.32344975
48	NCOR_22424771_ChIP-Seq_293T_Human	1.32074655
49	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.31090740
50	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.31090740
51	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.30258591
52	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.26820226
53	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.25810082
54	ELK1_19687146_ChIP-ChIP_HELA_Human	1.25689348
55	AR_20517297_ChIP-Seq_VCAP_Human	1.24083706
56	* KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.22715099
57	TCF4_23295773_ChIP-Seq_U87_Human	1.22039108
58	RNF2_27304074_Chip-Seq_NSC_Mouse	1.21254992
59	AR_25329375_ChIP-Seq_VCAP_Human	1.20423210
60	TCF4_22108803_ChIP-Seq_LS180_Human	1.19672856
61	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.19429420
62	HOXB7_26014856_ChIP-Seq_BT474_Human	1.18205207
63	STAT3_23295773_ChIP-Seq_U87_Human	1.17778998
64	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.17616454
65	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.17616454
66	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.17135515
67	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.16882339
68	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.16472419
69	SMAD4_21799915_ChIP-Seq_A2780_Human	1.16316337
70	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.16027249
71	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.14587075
72	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.14000091
73	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.12685667
74	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.12568505
75	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.11565229
76	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.10400361
77	ERA_21632823_ChIP-Seq_H3396_Human	1.09492657
78	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.08608990
79	MYC_19829295_ChIP-Seq_ESCs_Human	1.08606865
80	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.08415019
81	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.07969130
82	TAF2_19829295_ChIP-Seq_ESCs_Human	1.07298581
83	NANOG_20526341_ChIP-Seq_ESCs_Human	1.06538787
84	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.06362563
85	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.05418919
86	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.04848066
87	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.04687707
88	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.04465551
89	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.03281527
90	FOXH1_21741376_ChIP-Seq_EPCs_Human	1.03177532
91	RUNX2_22187159_ChIP-Seq_PCA_Human	1.03004567
92	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.01449794
93	FOXP3_21729870_ChIP-Seq_TREG_Human	1.01147996
94	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	0.99690036
95	FLI1_21867929_ChIP-Seq_TH2_Mouse	0.98839709
96	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	0.98195100
97	CRX_20693478_ChIP-Seq_RETINA_Mouse	0.97386308
98	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	0.94220790
99	PRDM14_20953172_ChIP-Seq_ESCs_Human	0.91241950
100	POU5F1_16153702_ChIP-ChIP_HESCs_Human	0.90591985

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002102_abnormal_ear_morphology	3.01653251
2	MP0006292_abnormal_olfactory_placode	3.00058772
3	MP0008877_abnormal_DNA_methylation	2.71487583
4	MP0002653_abnormal_ependyma_morphology	2.60470656
5	MP0003195_calcinosis	2.50927388
6	MP0005551_abnormal_eye_electrophysiolog	2.42892074
7	MP0003787_abnormal_imprinting	2.39798360
8	MP0003646_muscle_fatigue	2.17250635
9	MP0004147_increased_porphyrin_level	2.13259665
10	MP0002638_abnormal_pupillary_reflex	2.00502051
11	MP0001968_abnormal_touch/_nociception	1.99531025
12	MP0002837_dystrophic_cardiac_calcinosis	1.98462237
13	MP0001986_abnormal_taste_sensitivity	1.97575847
14	MP0008789_abnormal_olfactory_epithelium	1.90424126
15	MP0004142_abnormal_muscle_tone	1.90000325
16	MP0005646_abnormal_pituitary_gland	1.89556558
17	MP0001984_abnormal_olfaction	1.87052798
18	MP0002876_abnormal_thyroid_physiology	1.86844218
19	MP0004043_abnormal_pH_regulation	1.86576570
20	MP0006072_abnormal_retinal_apoptosis	1.86191393
21	MP0004885_abnormal_endolymph	1.85188006
22	MP0003880_abnormal_central_pattern	1.79906512
23	MP0005645_abnormal_hypothalamus_physiol	1.76696557
24	MP0009046_muscle_twitch	1.73437555
25	MP0009745_abnormal_behavioral_response	1.73066741
26	MP0008872_abnormal_physiological_respon	1.68730308
27	MP0005253_abnormal_eye_physiology	1.68300340
28	MP0002736_abnormal_nociception_after	1.63433148
29	MP0002272_abnormal_nervous_system	1.61847883
30	MP0008875_abnormal_xenobiotic_pharmacok	1.61103624
31	MP0004133_heterotaxia	1.58928796
32	MP0006276_abnormal_autonomic_nervous	1.52289503
33	MP0003011_delayed_dark_adaptation	1.51665602
34	MP0000372_irregular_coat_pigmentation	1.51597628
35	MP0005075_abnormal_melanosome_morpholog	1.51465792
36	MP0004145_abnormal_muscle_electrophysio	1.50618144
37	MP0005394_taste/olfaction_phenotype	1.50426221
38	MP0005499_abnormal_olfactory_system	1.50426221
39	MP0001485_abnormal_pinna_reflex	1.45732031
40	MP0000427_abnormal_hair_cycle	1.42911319
41	MP0000631_abnormal_neuroendocrine_gland	1.39018619
42	MP0002163_abnormal_gland_morphology	1.37546341
43	MP0002234_abnormal_pharynx_morphology	1.36374185
44	MP0003878_abnormal_ear_physiology	1.35414696
45	MP0005377_hearing/vestibular/ear_phenot	1.35414696
46	MP0001529_abnormal_vocalization	1.34526813
47	MP0001501_abnormal_sleep_pattern	1.34321336
48	MP0003122_maternal_imprinting	1.31327289
49	MP0005379_endocrine/exocrine_gland_phen	1.27698335
50	MP0005389_reproductive_system_phenotype	1.22128837
51	MP0001486_abnormal_startle_reflex	1.20077424
52	MP0002733_abnormal_thermal_nociception	1.19637809
53	MP0002557_abnormal_social/conspecific_i	1.19201155
54	MP0002160_abnormal_reproductive_system	1.18609516
55	MP0001905_abnormal_dopamine_level	1.17259044
56	MP0008775_abnormal_heart_ventricle	1.16860854
57	MP0001970_abnormal_pain_threshold	1.14964937
58	MP0002572_abnormal_emotion/affect_behav	1.13224680
59	MP0003136_yellow_coat_color	1.12398829
60	MP0003121_genomic_imprinting	1.12194153
61	MP0000569_abnormal_digit_pigmentation	1.11127379
62	MP0002938_white_spotting	1.11047885
63	MP0005174_abnormal_tail_pigmentation	1.10200566
64	MP0005195_abnormal_posterior_eye	1.08841637
65	MP0001919_abnormal_reproductive_system	1.07843440
66	MP0005084_abnormal_gallbladder_morpholo	1.07546648
67	MP0002064_seizures	1.06669319
68	MP0008995_early_reproductive_senescence	1.06342929
69	MP0002909_abnormal_adrenal_gland	1.04404698
70	MP0002063_abnormal_learning/memory/cond	1.02775931
71	MP0005167_abnormal_blood-brain_barrier	1.01795169
72	MP0002277_abnormal_respiratory_mucosa	0.99998048
73	MP0003635_abnormal_synaptic_transmissio	0.99723500
74	MP0003786_premature_aging	0.98839179
75	MP0002735_abnormal_chemical_nociception	0.98826773
76	MP0001502_abnormal_circadian_rhythm	0.96874547
77	MP0001293_anophthalmia	0.96216732
78	MP0005410_abnormal_fertilization	0.95645204
79	MP0000049_abnormal_middle_ear	0.95617779
80	MP0000778_abnormal_nervous_system	0.92866655
81	MP0002067_abnormal_sensory_capabilities	0.91884401
82	MP0002752_abnormal_somatic_nervous	0.91146117
83	MP0002095_abnormal_skin_pigmentation	0.91134924
84	MP0002928_abnormal_bile_duct	0.90043678
85	MP0001963_abnormal_hearing_physiology	0.88214331
86	MP0001324_abnormal_eye_pigmentation	0.88141935
87	MP0000230_abnormal_systemic_arterial	0.88086942
88	MP0002184_abnormal_innervation	0.87911132
89	MP0004742_abnormal_vestibular_system	0.87763619
90	MP0000026_abnormal_inner_ear	0.86251537
91	MP0003718_maternal_effect	0.84661853
92	MP0005332_abnormal_amino_acid	0.83646650
93	MP0005386_behavior/neurological_phenoty	0.82752470
94	MP0004924_abnormal_behavior	0.82752470
95	MP0002734_abnormal_mechanical_nocicepti	0.82538251
96	MP0001764_abnormal_homeostasis	0.80719741
97	MP0001188_hyperpigmentation	0.80288124
98	MP0010386_abnormal_urinary_bladder	0.79881054
99	MP0002229_neurodegeneration	0.78170693
100	MP0003698_abnormal_male_reproductive	0.77221551

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Molar tooth sign on MRI (HP:0002419)	4.41296555
2	Abnormality of midbrain morphology (HP:0002418)	4.41296555
3	Pancreatic cysts (HP:0001737)	4.17900966
4	Congenital stationary night blindness (HP:0007642)	3.82199570
5	Pancreatic fibrosis (HP:0100732)	3.81148212
6	Nephronophthisis (HP:0000090)	3.69780728
7	True hermaphroditism (HP:0010459)	3.55180212
8	Chronic hepatic failure (HP:0100626)	3.38683998
9	Acute necrotizing encephalopathy (HP:0006965)	3.31587229
10	Type II lissencephaly (HP:0007260)	3.10773218
11	Medial flaring of the eyebrow (HP:0010747)	3.10004465
12	Abnormality of the renal medulla (HP:0100957)	3.06346713
13	Acute encephalopathy (HP:0006846)	3.05612986
14	Abnormality of the renal cortex (HP:0011035)	2.95576949
15	Abnormal mitochondria in muscle tissue (HP:0008316)	2.89990027
16	Mitochondrial inheritance (HP:0001427)	2.88906292
17	Progressive macrocephaly (HP:0004481)	2.84283356
18	Abolished electroretinogram (ERG) (HP:0000550)	2.83686474
19	Increased CSF lactate (HP:0002490)	2.79192144
20	Pendular nystagmus (HP:0012043)	2.76501321
21	Polydipsia (HP:0001959)	2.65394861
22	Abnormal drinking behavior (HP:0030082)	2.65394861
23	Abnormal rod and cone electroretinograms (HP:0008323)	2.64558687
24	Tubular atrophy (HP:0000092)	2.62632425
25	Attenuation of retinal blood vessels (HP:0007843)	2.60270354
26	Cystic liver disease (HP:0006706)	2.54093843
27	3-Methylglutaconic aciduria (HP:0003535)	2.51250401
28	Gait imbalance (HP:0002141)	2.50214246
29	Bile duct proliferation (HP:0001408)	2.44392970
30	Abnormal biliary tract physiology (HP:0012439)	2.44392970
31	Sclerocornea (HP:0000647)	2.42133389
32	Congenital primary aphakia (HP:0007707)	2.40949872
33	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.34874165
34	Hepatocellular necrosis (HP:0001404)	2.29895998
35	Lipid accumulation in hepatocytes (HP:0006561)	2.28146649
36	Optic disc pallor (HP:0000543)	2.26337935
37	Nephrogenic diabetes insipidus (HP:0009806)	2.25831365
38	Cerebellar dysplasia (HP:0007033)	2.23358238
39	Lissencephaly (HP:0001339)	2.23139704
40	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.22328129
41	Anencephaly (HP:0002323)	2.21735136
42	Renal cortical cysts (HP:0000803)	2.17113058
43	Increased hepatocellular lipid droplets (HP:0006565)	2.16160186
44	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.15201780
45	Abnormality of alanine metabolism (HP:0010916)	2.15201780
46	Hyperalaninemia (HP:0003348)	2.15201780
47	Inability to walk (HP:0002540)	2.15174227
48	Abnormal respiratory motile cilium morphology (HP:0005938)	2.13356064
49	Abnormal respiratory epithelium morphology (HP:0012253)	2.13356064
50	Progressive inability to walk (HP:0002505)	2.12724303
51	Polyuria (HP:0000103)	2.12695081
52	Hepatic necrosis (HP:0002605)	2.10987251
53	Absent/shortened dynein arms (HP:0200106)	2.10009454
54	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.10009454
55	Increased serum lactate (HP:0002151)	2.07271783
56	Congenital hepatic fibrosis (HP:0002612)	2.06739646
57	Keratoconus (HP:0000563)	2.06448936
58	Increased corneal curvature (HP:0100692)	2.06448936
59	Pachygyria (HP:0001302)	2.06297569
60	Hyperglycinuria (HP:0003108)	2.05509836
61	Postaxial foot polydactyly (HP:0001830)	2.02583413
62	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.01033110
63	Cerebral edema (HP:0002181)	2.00855671
64	Optic nerve hypoplasia (HP:0000609)	2.00819872
65	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	2.00259908
66	Tachypnea (HP:0002789)	1.99442888
67	Hyperventilation (HP:0002883)	1.99079373
68	Aplasia/Hypoplasia of the spleen (HP:0010451)	1.96842611
69	Hypomagnesemia (HP:0002917)	1.94611306
70	Hyperglycinemia (HP:0002154)	1.94479984
71	Genital tract atresia (HP:0001827)	1.93862683
72	Large for gestational age (HP:0001520)	1.93825698
73	Broad-based gait (HP:0002136)	1.93656843
74	Microretrognathia (HP:0000308)	1.93215371
75	Chorioretinal atrophy (HP:0000533)	1.92618830
76	Methylmalonic acidemia (HP:0002912)	1.90150193
77	Vaginal atresia (HP:0000148)	1.89784738
78	Congenital, generalized hypertrichosis (HP:0004540)	1.87100602
79	Severe muscular hypotonia (HP:0006829)	1.86077963
80	Decreased central vision (HP:0007663)	1.85897561
81	Retinal dysplasia (HP:0007973)	1.85047763
82	Bony spicule pigmentary retinopathy (HP:0007737)	1.84813132
83	Hemiparesis (HP:0001269)	1.83862396
84	Methylmalonic aciduria (HP:0012120)	1.83757047
85	Male pseudohermaphroditism (HP:0000037)	1.80312139
86	Lactic acidosis (HP:0003128)	1.80166734
87	Colon cancer (HP:0003003)	1.80093983
88	Aplasia/Hypoplasia of the tibia (HP:0005772)	1.80079492
89	Asplenia (HP:0001746)	1.78356889
90	Ketosis (HP:0001946)	1.78048117
91	Progressive microcephaly (HP:0000253)	1.76740775
92	Postaxial hand polydactyly (HP:0001162)	1.76506563
93	Limb dystonia (HP:0002451)	1.76335648
94	Absent thumb (HP:0009777)	1.74703403
95	Abnormal urine output (HP:0012590)	1.72849237
96	Gaze-evoked nystagmus (HP:0000640)	1.72716460
97	Abnormality of the labia minora (HP:0012880)	1.72075516
98	Furrowed tongue (HP:0000221)	1.71285759
99	Occipital encephalocele (HP:0002085)	1.69574973
100	Aplasia/Hypoplasia of the fovea (HP:0008060)	1.66965067

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	BMPR1B	4.08642354
2	FRK	3.90490167
3	ADRBK2	3.47107459
4	ZAK	2.96588355
5	WNK4	2.79423885
6	GRK1	2.66843009
7	NUAK1	2.64816478
8	TXK	2.45131721
9	WNK3	2.44096297
10	MAP4K2	2.36661677
11	PINK1	2.29640069
12	ACVR1B	2.19770948
13	MAP3K4	1.98963000
14	BCKDK	1.89200208
15	TLK1	1.84319157
16	CASK	1.74420723
17	MAPK13	1.67789079
18	MAP2K7	1.59921409
19	TIE1	1.57193647
20	DYRK2	1.50291504
21	DAPK2	1.46529821
22	STK16	1.38926392
23	OXSR1	1.38388976
24	TAOK3	1.35048039
25	TGFBR1	1.32810188
26	STK39	1.29928979
27	TNIK	1.28326050
28	MKNK2	1.22307476
29	MST4	1.16519282
30	PLK2	1.16178534
31	CAMKK2	1.14689984
32	EPHA4	1.09067166
33	INSRR	1.06425698
34	ADRBK1	1.04595756
35	PRKCG	1.00822693
36	CSNK1G2	1.00731562
37	MUSK	0.98991894
38	PAK3	0.97942289
39	CSNK1G3	0.97165302
40	TRIM28	0.92522179
41	CSNK1G1	0.90703645
42	LIMK1	0.90112140
43	PRKCE	0.89283722
44	PHKG1	0.88451396
45	PHKG2	0.88451396
46	PRKCI	0.83920067
47	MARK1	0.82887971
48	MAP2K6	0.82506804
49	BCR	0.81892133
50	BRSK2	0.80333329
51	VRK1	0.78919498
52	NME1	0.75782222
53	MAPKAPK5	0.74843225
54	ERBB3	0.74131881
55	MAPKAPK3	0.73326775
56	RPS6KA5	0.72729346
57	PRKCQ	0.71030239
58	CSNK1A1L	0.69283247
59	PIK3CA	0.66873957
60	EIF2AK3	0.65723729
61	PLK3	0.65208494
62	NTRK2	0.63702049
63	KIT	0.62848116
64	CAMKK1	0.62451917
65	PLK4	0.61779090
66	PASK	0.60508567
67	TEC	0.57004072
68	STK11	0.56603145
69	CDK8	0.55956788
70	NTRK3	0.52944377
71	CAMK2A	0.50311747
72	VRK2	0.50204490
73	WNK1	0.48543270
74	CAMK1	0.47355354
75	MKNK1	0.46631443
76	IKBKB	0.46185049
77	AKT3	0.46112379
78	GRK7	0.44869981
79	PRKACA	0.43451293
80	CSNK1A1	0.43299448
81	ITK	0.43105697
82	FGFR2	0.41953114
83	PLK1	0.41057950
84	WEE1	0.39584889
85	KDR	0.36812516
86	SIK2	0.36519823
87	DYRK3	0.36026969
88	CSNK1D	0.35380090
89	PRKCA	0.34360191
90	TNK2	0.33448710
91	NLK	0.33069453
92	PRKCZ	0.32551256
93	PTK2B	0.32377605
94	MINK1	0.30839660
95	OBSCN	0.29811866
96	CAMK2D	0.28600263
97	IGF1R	0.28342713
98	ATR	0.27970013
99	PKN1	0.27121422
100	CAMK4	0.24783387

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Oxidative phosphorylation_Homo sapiens_hsa00190	3.02886422
2	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.95409829
3	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.77284593
4	Linoleic acid metabolism_Homo sapiens_hsa00591	2.39957884
5	Protein export_Homo sapiens_hsa03060	2.33779270
6	Parkinsons disease_Homo sapiens_hsa05012	2.33241042
7	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.30368252
8	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.15781509
9	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	2.15422786
10	Phototransduction_Homo sapiens_hsa04744	2.14764018
11	Nitrogen metabolism_Homo sapiens_hsa00910	2.01324762
12	Butanoate metabolism_Homo sapiens_hsa00650	1.97495158
13	RNA polymerase_Homo sapiens_hsa03020	1.94347203
14	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.91373494
15	Basal transcription factors_Homo sapiens_hsa03022	1.87150817
16	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.80956147
17	Nicotine addiction_Homo sapiens_hsa05033	1.80223583
18	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.74752353
19	Selenocompound metabolism_Homo sapiens_hsa00450	1.68685086
20	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.63791849
21	Homologous recombination_Homo sapiens_hsa03440	1.60720078
22	Ether lipid metabolism_Homo sapiens_hsa00565	1.58659431
23	Tryptophan metabolism_Homo sapiens_hsa00380	1.58233919
24	Propanoate metabolism_Homo sapiens_hsa00640	1.57909831
25	Fanconi anemia pathway_Homo sapiens_hsa03460	1.53768514
26	Proteasome_Homo sapiens_hsa03050	1.53739078
27	Huntingtons disease_Homo sapiens_hsa05016	1.53340749
28	Alzheimers disease_Homo sapiens_hsa05010	1.44699831
29	Caffeine metabolism_Homo sapiens_hsa00232	1.43423532
30	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.42035046
31	RNA degradation_Homo sapiens_hsa03018	1.39731925
32	Peroxisome_Homo sapiens_hsa04146	1.37279234
33	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.35614945
34	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.34736484
35	Cardiac muscle contraction_Homo sapiens_hsa04260	1.34584120
36	Ribosome_Homo sapiens_hsa03010	1.34156690
37	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.33464706
38	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.22135476
39	One carbon pool by folate_Homo sapiens_hsa00670	1.17625412
40	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.10392040
41	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.10028067
42	Taste transduction_Homo sapiens_hsa04742	1.07576928
43	Primary immunodeficiency_Homo sapiens_hsa05340	1.06089788
44	Asthma_Homo sapiens_hsa05310	1.03796596
45	Olfactory transduction_Homo sapiens_hsa04740	1.03706643
46	Morphine addiction_Homo sapiens_hsa05032	1.01781336
47	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.99748556
48	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.98435511
49	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.98163451
50	Collecting duct acid secretion_Homo sapiens_hsa04966	0.98018290
51	Type I diabetes mellitus_Homo sapiens_hsa04940	0.95338599
52	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.94458143
53	Chemical carcinogenesis_Homo sapiens_hsa05204	0.92163386
54	Insulin secretion_Homo sapiens_hsa04911	0.90659308
55	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.86467394
56	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.84989232
57	Regulation of autophagy_Homo sapiens_hsa04140	0.83473210
58	Sulfur metabolism_Homo sapiens_hsa00920	0.82925634
59	Graft-versus-host disease_Homo sapiens_hsa05332	0.80941541
60	Retinol metabolism_Homo sapiens_hsa00830	0.80631167
61	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.80363638
62	beta-Alanine metabolism_Homo sapiens_hsa00410	0.80197246
63	GABAergic synapse_Homo sapiens_hsa04727	0.79690770
64	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.78273638
65	Allograft rejection_Homo sapiens_hsa05330	0.76690073
66	Metabolic pathways_Homo sapiens_hsa01100	0.74632957
67	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.70164650
68	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.68889272
69	Purine metabolism_Homo sapiens_hsa00230	0.68260095
70	Serotonergic synapse_Homo sapiens_hsa04726	0.68112942
71	Circadian entrainment_Homo sapiens_hsa04713	0.66941121
72	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.65927035
73	ABC transporters_Homo sapiens_hsa02010	0.65473291
74	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.65032024
75	Fat digestion and absorption_Homo sapiens_hsa04975	0.64617238
76	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.63324602
77	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.62837077
78	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.62139438
79	Non-homologous end-joining_Homo sapiens_hsa03450	0.61292283
80	Rheumatoid arthritis_Homo sapiens_hsa05323	0.61039424
81	Glutamatergic synapse_Homo sapiens_hsa04724	0.60438388
82	Steroid biosynthesis_Homo sapiens_hsa00100	0.60138850
83	Pyrimidine metabolism_Homo sapiens_hsa00240	0.60093478
84	Nucleotide excision repair_Homo sapiens_hsa03420	0.57994078
85	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.57665327
86	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.53591806
87	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.53490286
88	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.51085038
89	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.50987879
90	Sulfur relay system_Homo sapiens_hsa04122	0.47614946
91	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.47220811
92	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.47166038
93	Fatty acid degradation_Homo sapiens_hsa00071	0.45504895
94	Glycerolipid metabolism_Homo sapiens_hsa00561	0.42121702
95	Fatty acid elongation_Homo sapiens_hsa00062	0.41221672
96	Salivary secretion_Homo sapiens_hsa04970	0.39116528
97	Dopaminergic synapse_Homo sapiens_hsa04728	0.36804170
98	Calcium signaling pathway_Homo sapiens_hsa04020	0.36671812
99	Mineral absorption_Homo sapiens_hsa04978	0.34323372
100	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.32324977

INGX

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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