INHBA

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the TGF-beta (transforming growth factor-beta) superfamily of proteins. The encoded preproprotein is proteolytically processed to generate a subunit of the dimeric activin and inhibin protein complexes. These complexes activate and inhibit, respectively, follicle stimulating hormone secretion from the pituitary gland. The encoded protein also plays a role in eye, tooth and testis development. Elevated expression of this gene may be associated with cancer cachexia in human patients. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of macrophage activation (GO:0043032)5.53281551
2positive regulation of chemokine biosynthetic process (GO:0045080)5.34948977
3wound healing, spreading of epidermal cells (GO:0035313)5.19202410
4substrate-dependent cell migration (GO:0006929)4.99656923
5regulation of chemokine biosynthetic process (GO:0045073)4.74658316
6positive regulation of heterotypic cell-cell adhesion (GO:0034116)4.61294790
7neutrophil activation involved in immune response (GO:0002283)4.60810831
8positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)4.60797199
9collagen fibril organization (GO:0030199)4.56500170
10skin morphogenesis (GO:0043589)4.50423843
11antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.43862989
12regulation of fever generation (GO:0031620)4.42238464
13positive regulation of heat generation (GO:0031652)4.36374380
14positive regulation of chemokine secretion (GO:0090197)4.31970870
15hydrogen peroxide biosynthetic process (GO:0050665)4.17882716
16response to peptidoglycan (GO:0032494)4.08379269
17regulation of heterotypic cell-cell adhesion (GO:0034114)4.03480745
18positive regulation by symbiont of host defense response (GO:0052509)4.02560537
19modulation by symbiont of host defense response (GO:0052031)4.02560537
20modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.02560537
21modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.02560537
22positive regulation by organism of defense response of other organism involved in symbiotic interact4.02560537
23modulation by symbiont of host immune response (GO:0052553)4.02560537
24negative regulation of axon extension involved in axon guidance (GO:0048843)4.02476481
25regulation of mononuclear cell migration (GO:0071675)4.01152321
26regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.99724907
27wound healing, spreading of cells (GO:0044319)3.89303022
28regulation of chemokine secretion (GO:0090196)3.88504194
29regulation of syncytium formation by plasma membrane fusion (GO:0060142)3.85297235
30lipopolysaccharide-mediated signaling pathway (GO:0031663)3.78290285
31cellular response to interferon-alpha (GO:0035457)3.78204132
32positive regulation of blood vessel endothelial cell migration (GO:0043536)3.71076315
33regulation of vitamin D biosynthetic process (GO:0060556)3.69987404
34chondroitin sulfate biosynthetic process (GO:0030206)3.69777717
35cell adhesion mediated by integrin (GO:0033627)3.69324324
36superoxide anion generation (GO:0042554)3.64742226
37reactive oxygen species biosynthetic process (GO:1903409)3.62169707
38mesenchymal-epithelial cell signaling (GO:0060638)3.60069718
39eosinophil chemotaxis (GO:0048245)3.55086489
40positive regulation of monocyte chemotaxis (GO:0090026)3.54899904
41collagen metabolic process (GO:0032963)3.49264190
42granulocyte activation (GO:0036230)3.49193831
43protein heterotrimerization (GO:0070208)3.48489718
44chondrocyte proliferation (GO:0035988)3.46159849
45collagen catabolic process (GO:0030574)3.43778439
46hemidesmosome assembly (GO:0031581)3.42274945
47positive regulation of natural killer cell differentiation (GO:0032825)3.42239643
48extracellular matrix disassembly (GO:0022617)3.36851081
49respiratory burst (GO:0045730)3.36595175
50regulation of branching involved in salivary gland morphogenesis (GO:0060693)3.33952744
51positive regulation of myeloid leukocyte cytokine production involved in immune response (GO:00610813.29089022
52decidualization (GO:0046697)3.27663228
53positive regulation of nitric oxide biosynthetic process (GO:0045429)3.25312874
54protein localization to endosome (GO:0036010)3.24935826
55regulation of integrin-mediated signaling pathway (GO:2001044)3.22954827
56regulation of T-helper 1 cell differentiation (GO:0045625)3.22573310
57regulation of vitamin metabolic process (GO:0030656)3.22526851
58leukocyte aggregation (GO:0070486)3.21414204
59positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.20947856
60chondrocyte development (GO:0002063)3.19515684
61positive regulation of astrocyte differentiation (GO:0048711)3.18110099
62macrophage activation involved in immune response (GO:0002281)3.18038010
63multicellular organismal macromolecule metabolic process (GO:0044259)3.16353739
64natural killer cell mediated immunity (GO:0002228)3.15897764
65natural killer cell mediated cytotoxicity (GO:0042267)3.15897764
66eosinophil migration (GO:0072677)3.14269882
67regulation of heat generation (GO:0031650)3.13781372
68multicellular organismal catabolic process (GO:0044243)3.13204429
69heparan sulfate proteoglycan biosynthetic process (GO:0015012)3.12089644
70sequestering of extracellular ligand from receptor (GO:0035581)3.10587840
71regulation of type B pancreatic cell apoptotic process (GO:2000674)3.10486028
72regulation of monocyte chemotaxis (GO:0090025)3.09996197
73stress fiber assembly (GO:0043149)3.06424683
74regulation of macrophage cytokine production (GO:0010935)3.05920342
75regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)3.04521607
76production of molecular mediator involved in inflammatory response (GO:0002532)3.04314256
77retina vasculature morphogenesis in camera-type eye (GO:0061299)3.03637989
78negative regulation of axon guidance (GO:1902668)3.03467063
79multicellular organismal metabolic process (GO:0044236)3.02052412
80wound healing (GO:0042060)3.01465807
81hypotonic response (GO:0006971)3.00083736
82basement membrane organization (GO:0071711)3.00015079
83positive regulation of interferon-alpha production (GO:0032727)2.99998164
84positive regulation of endothelial cell apoptotic process (GO:2000353)2.97545981
85negative regulation by host of viral transcription (GO:0043922)2.96894327
86positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.96858837
87regulation of podosome assembly (GO:0071801)2.94494435
88regulation of lymphocyte chemotaxis (GO:1901623)2.94019488
89cell-substrate junction assembly (GO:0007044)2.94004484
90detection of molecule of bacterial origin (GO:0032490)2.93627364
91* mesodermal cell differentiation (GO:0048333)2.93245037
92vascular endothelial growth factor signaling pathway (GO:0038084)2.91206292
93cellular response to vitamin D (GO:0071305)2.90956463
94negative regulation of myeloid cell apoptotic process (GO:0033033)2.90871220
95negative regulation of chondrocyte differentiation (GO:0032331)2.90713154
96cellular response to vitamin (GO:0071295)2.89203886
97monocyte chemotaxis (GO:0002548)2.87635998
98positive regulation vascular endothelial growth factor production (GO:0010575)2.86767541
99positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.86613996
100regulation of metalloenzyme activity (GO:0048552)2.86169262
101vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.86073797
102regulation of axon extension involved in axon guidance (GO:0048841)2.85742268
103positive regulation of p38MAPK cascade (GO:1900745)2.83927849
104neutrophil activation (GO:0042119)2.83513369
105regulation of interferon-alpha production (GO:0032647)2.83225417
106adhesion of symbiont to host cell (GO:0044650)2.80915588
107virion attachment to host cell (GO:0019062)2.80915588
108kidney mesenchyme development (GO:0072074)2.80554476
109positive regulation of NF-kappaB import into nucleus (GO:0042346)2.80242369
110positive regulation of interleukin-6 production (GO:0032755)2.80031632
111positive regulation of tyrosine phosphorylation of Stat3 protein (GO:0042517)2.78988889
112positive regulation of endothelial cell migration (GO:0010595)2.78841661
113regulation of vascular endothelial growth factor production (GO:0010574)2.78477374
114regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:00033392.77975121
115cell migration involved in sprouting angiogenesis (GO:0002042)2.77655869
116regulation of apoptotic process involved in morphogenesis (GO:1902337)2.77335826
117chronic inflammatory response (GO:0002544)2.77270640
118positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)2.76832305
119myeloid cell homeostasis (GO:0002262)2.76317045
120regulation of transforming growth factor beta2 production (GO:0032909)2.75905407
121heterotypic cell-cell adhesion (GO:0034113)2.75074898
122* endodermal cell differentiation (GO:0035987)2.74860419
123positive regulation of chemokine production (GO:0032722)2.74857321
124positive regulation of blood coagulation (GO:0030194)2.74394062
125positive regulation of hemostasis (GO:1900048)2.74394062
126positive regulation of macrophage cytokine production (GO:0060907)2.73950642
127positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557)2.73350166
128positive regulation of axon extension (GO:0045773)2.71255237
129positive regulation of tumor necrosis factor production (GO:0032760)2.71144840
130positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.70120663
131regulation of nitric oxide biosynthetic process (GO:0045428)2.68328973
132low-density lipoprotein particle clearance (GO:0034383)2.67453365
133response to manganese ion (GO:0010042)2.67225929
134response to interferon-alpha (GO:0035455)2.66261410
135regulation of cell migration involved in sprouting angiogenesis (GO:0090049)2.66229270
136regulation of collagen metabolic process (GO:0010712)2.65582214
137regulation of T-helper 1 type immune response (GO:0002825)2.65502040
138COPII vesicle coating (GO:0048208)2.65440671
139cell migration involved in heart development (GO:0060973)2.65408798
140negative regulation of smooth muscle cell migration (GO:0014912)2.64542549
141sprouting angiogenesis (GO:0002040)2.64054003
142regulation of membrane protein ectodomain proteolysis (GO:0051043)2.63886929
143COPI coating of Golgi vesicle (GO:0048205)2.63728585
144Golgi transport vesicle coating (GO:0048200)2.63728585
145negative regulation of interleukin-17 production (GO:0032700)2.63520619
146positive regulation of lymphocyte migration (GO:2000403)2.62487623
147regulation of integrin activation (GO:0033623)2.62407065
148positive regulation of cytokine biosynthetic process (GO:0042108)2.62258083
149substrate adhesion-dependent cell spreading (GO:0034446)2.61500901
150extracellular matrix organization (GO:0030198)2.61314793
151positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.60834793
152positive regulation of osteoblast proliferation (GO:0033690)2.60738511
153adhesion of symbiont to host (GO:0044406)2.60684173
154response to vitamin D (GO:0033280)2.60666563
155extracellular structure organization (GO:0043062)2.60390971
156negative regulation of lipid storage (GO:0010888)2.60125459
157barbed-end actin filament capping (GO:0051016)2.59448918
158regulation of transforming growth factor beta1 production (GO:0032908)2.58896838
159pathway-restricted SMAD protein phosphorylation (GO:0060389)2.58627241
160neutrophil chemotaxis (GO:0030593)2.57276794
161negative regulation of interleukin-12 production (GO:0032695)2.57017171
162mammary gland epithelial cell proliferation (GO:0033598)2.56052198
163regulation of chemokine-mediated signaling pathway (GO:0070099)2.56050561
164positive regulation of epithelial cell migration (GO:0010634)2.56012939
165response to muramyl dipeptide (GO:0032495)2.55838646
166extracellular fibril organization (GO:0043206)2.54067091
167positive regulation of coagulation (GO:0050820)2.52983308
168extracellular matrix assembly (GO:0085029)2.52920702
169regulation of interleukin-8 secretion (GO:2000482)2.51870887
170regulation of macrophage activation (GO:0043030)2.51627237
171glial cell migration (GO:0008347)2.51591447
172myeloid cell activation involved in immune response (GO:0002275)2.51206249
173positive regulation of acute inflammatory response (GO:0002675)2.51143721
174regulation of cytokine secretion involved in immune response (GO:0002739)2.46721248
175fibril organization (GO:0097435)2.45426922
176positive regulation of type 2 immune response (GO:0002830)2.44712694
177keratan sulfate catabolic process (GO:0042340)2.43733066

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human8.26464462
2IRF8_21731497_ChIP-ChIP_J774_Mouse4.83858164
3* IRF8_22096565_ChIP-ChIP_GC-B_Human4.38870360
4TRIM28_21343339_ChIP-Seq_HEK293_Human4.23320506
5TP63_17297297_ChIP-ChIP_HaCaT_Human4.10338525
6* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human3.49972630
7* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse3.41001113
8TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.04628546
9FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.03125693
10RARG_19884340_ChIP-ChIP_MEFs_Mouse3.01591521
11EGR1_19374776_ChIP-ChIP_THP-1_Human3.01080441
12SMAD_19615063_ChIP-ChIP_OVARY_Human2.87886280
13* IRF8_27001747_Chip-Seq_BMDM_Mouse2.82069747
14SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.80361346
15* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.74800338
16NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.60808400
17NRF2_20460467_ChIP-Seq_MEFs_Mouse2.40742205
18NFE2L2_20460467_ChIP-Seq_MEFs_Mouse2.40742205
19IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.38469499
20MYB_21317192_ChIP-Seq_ERMYB_Mouse2.29721505
21IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.26163814
22CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse2.18761715
23SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.17881276
24* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse2.11892376
25STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.07651628
26* CJUN_26792858_Chip-Seq_BT549_Human1.93379105
27* STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.90004570
28MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.84731442
29TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.77200886
30SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.70493542
31SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.70493542
32PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.67780226
33RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.66999011
34* VDR_24787735_ChIP-Seq_THP-1_Human1.53103018
35SOX2_20726797_ChIP-Seq_SW620_Human1.51186326
36CDX2_19796622_ChIP-Seq_MESCs_Mouse1.49453513
37TP53_18474530_ChIP-ChIP_U2OS_Human1.48784553
38NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.46414876
39BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.46137204
40STAT4_19710469_ChIP-ChIP_TH1__Mouse1.46088102
41* JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.44045241
42ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.40996084
43STAT6_21828071_ChIP-Seq_BEAS2B_Human1.38994960
44* BRD4_25478319_ChIP-Seq_HGPS_Human1.37392030
45SOX9_24532713_ChIP-Seq_HFSC_Mouse1.37058751
46* JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.36779383
47CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.36118222
48* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.34133675
49GATA2_21666600_ChIP-Seq_HMVEC_Human1.32232866
50THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.29268625
51* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.28950396
52PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.25553307
53* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.23722984
54CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.22585579
55ESR1_21235772_ChIP-Seq_MCF-7_Human1.18336111
56VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.17977354
57TP53_22127205_ChIP-Seq_IMR90_Human1.16232038
58STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.15534194
59BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.15496268
60NFIB_24661679_ChIP-Seq_LUNG_Mouse1.13873928
61SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.11293669
62KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.10824017
63TBX20_22080862_ChIP-Seq_HEART_Mouse1.10649380
64TBX20_22328084_ChIP-Seq_HEART_Mouse1.10649380
65TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.10248815
66CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.09200864
67* PPAR_26484153_Chip-Seq_NCI-H1993_Human1.09081850
68NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.08136311
69* PU_27001747_Chip-Seq_BMDM_Mouse1.07955558
70SALL4_18804426_ChIP-ChIP_XEN_Mouse1.05648826
71* SA1_22415368_ChIP-Seq_MEFs_Mouse1.05440212
72PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.05217998
73EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.04871227
74ESR2_21235772_ChIP-Seq_MCF-7_Human1.03325373
75* SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.03217464
76* TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.02645517
77ZNF217_24962896_ChIP-Seq_MCF-7_Human1.02239525
78FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.00770212
79CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.00669579
80AHR_22903824_ChIP-Seq_MCF-7_Human0.98986019
81KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.98729583
82SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.96900647
83STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.96811388
84* ELK3_25401928_ChIP-Seq_HUVEC_Human0.95664638
85TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.95078374
86MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.92312735
87NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.91754903
88* VDR_24763502_ChIP-Seq_THP-1_Human0.91134215
89TP53_16413492_ChIP-PET_HCT116_Human0.89778511
90ATF3_27146783_Chip-Seq_COLON_Human0.89725154
91RXR_22108803_ChIP-Seq_LS180_Human0.89023523
92PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.88931630
93FOXO3_23340844_ChIP-Seq_DLD1_Human0.88064785
94* HIF1A_21447827_ChIP-Seq_MCF-7_Human0.87936429
95IKZF1_21737484_ChIP-ChIP_HCT116_Human0.87424762
96SMAD3_21741376_ChIP-Seq_HESCs_Human0.87104767
97SPI1_23547873_ChIP-Seq_NB4_Human0.86918383
98* FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.86725914
99ESR1_20079471_ChIP-ChIP_T-47D_Human0.86512055
100UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.86408431
101RUNX_20019798_ChIP-Seq_JUKART_Human0.86267245
102* SMC1_22415368_ChIP-Seq_MEFs_Mouse0.85901287
103ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.85065831
104TP53_23651856_ChIP-Seq_MEFs_Mouse0.83491613
105EP300_21415370_ChIP-Seq_HL-1_Mouse0.82990636
106RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.81441964
107PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.80995013
108P63_26484246_Chip-Seq_KERATINOCYTES_Human0.80201238
109* TP63_23658742_ChIP-Seq_EP156T_Human0.78294828
110CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.78262031
111PIAS1_25552417_ChIP-Seq_VCAP_Human0.76145719
112WT1_19549856_ChIP-ChIP_CCG9911_Human0.75731958
113NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.75369222
114* UBF1/2_26484160_Chip-Seq_HMECs_Human0.75099044
115EZH2_18974828_ChIP-Seq_MESCs_Mouse0.75059522
116RNF2_18974828_ChIP-Seq_MESCs_Mouse0.75059522
117PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.74875057
118FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.74131153
119MYB_26560356_Chip-Seq_TH2_Human0.73561752
120SPI1_23127762_ChIP-Seq_K562_Human0.72102147
121CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.72062487
122SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.69730416
123ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.69460489
124CLOCK_20551151_ChIP-Seq_293T_Human0.69256303
125RUNX1_22412390_ChIP-Seq_EML_Mouse0.67952904
126GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.67829838
127ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.67731689
128NFI_21473784_ChIP-Seq_ESCs_Mouse0.67616605
129FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.64489740
130* SMC3_22415368_ChIP-Seq_MEFs_Mouse0.64338145
131WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.63186533
132* PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.62029888
133KLF5_25053715_ChIP-Seq_YYC3_Human0.61709702
134ELK1_22589737_ChIP-Seq_MCF10A_Human0.61273430

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen3.65006492
2MP0003436_decreased_susceptibility_to3.61519705
3MP0003303_peritoneal_inflammation3.19981040
4MP0010352_gastrointestinal_tract_polyps3.08686146
5MP0003724_increased_susceptibility_to2.99336864
6MP0009785_altered_susceptibility_to2.95255365
7MP0002148_abnormal_hypersensitivity_rea2.92796270
8MP0003950_abnormal_plasma_membrane2.84047616
9MP0003279_aneurysm2.83942469
10MP0006082_CNS_inflammation2.81187031
11MP0003705_abnormal_hypodermis_morpholog2.67496458
12MP0002419_abnormal_innate_immunity2.54941459
13MP0005503_abnormal_tendon_morphology2.54107594
14MP0001533_abnormal_skeleton_physiology2.52784276
15MP0001835_abnormal_antigen_presentation2.49654204
16MP0005000_abnormal_immune_tolerance2.43746578
17MP0001853_heart_inflammation2.31493089
18MP0003300_gastrointestinal_ulcer2.12268824
19MP0009764_decreased_sensitivity_to2.10027962
20MP0005025_abnormal_response_to2.07862918
21MP0000343_altered_response_to2.01973702
22MP0002998_abnormal_bone_remodeling2.01419238
23MP0005164_abnormal_response_to1.99135522
24MP0005275_abnormal_skin_tensile1.86824349
25MP0005023_abnormal_wound_healing1.85132440
26MP0002254_reproductive_system_inflammat1.83468910
27MP0005390_skeleton_phenotype1.83198342
28MP0003566_abnormal_cell_adhesion1.82869808
29MP0003448_altered_tumor_morphology1.79431172
30MP0005257_abnormal_intraocular_pressure1.75450428
31MP0002295_abnormal_pulmonary_circulatio1.73109579
32MP0000858_altered_metastatic_potential1.72457762
33MP0003091_abnormal_cell_migration1.72355683
34MP0008004_abnormal_stomach_pH1.71243880
35MP0003195_calcinosis1.67973972
36MP0004947_skin_inflammation1.64808523
37MP0002452_abnormal_antigen_presenting1.64622869
38MP0002933_joint_inflammation1.59545111
39MP0002006_tumorigenesis1.59310069
40MP0002405_respiratory_system_inflammati1.57654580
41MP0000013_abnormal_adipose_tissue1.56599303
42MP0001958_emphysema1.54620547
43MP0004510_myositis1.54608536
44MP0001879_abnormal_lymphatic_vessel1.54023927
45MP0003075_altered_response_to1.51119576
46MP0004272_abnormal_basement_membrane1.50242370
47MP0002723_abnormal_immune_serum1.50214481
48MP0005387_immune_system_phenotype1.49191928
49MP0001790_abnormal_immune_system1.49191928
50MP0005464_abnormal_platelet_physiology1.48947988
51MP0002282_abnormal_trachea_morphology1.40147371
52MP0005595_abnormal_vascular_smooth1.38514717
53MP0004883_abnormal_blood_vessel1.38415624
54MP0009250_abnormal_appendicular_skeleto1.36919632
55MP0005166_decreased_susceptibility_to1.36208451
56MP0009384_cardiac_valve_regurgitation1.34105149
57MP0005623_abnormal_meninges_morphology1.32872127
58MP0001845_abnormal_inflammatory_respons1.32419192
59MP0003828_pulmonary_edema1.29718688
60MP0009840_abnormal_foam_cell1.28081300
61MP0003186_abnormal_redox_activity1.27938187
62MP0000685_abnormal_immune_system1.26709287
63MP0001819_abnormal_immune_cell1.22268888
64MP0005508_abnormal_skeleton_morphology1.21874364
65MP0003795_abnormal_bone_structure1.21658025
66MP0002168_other_aberrant_phenotype1.20674715
67* MP0001299_abnormal_eye_distance/1.19571269
68MP0009780_abnormal_chondrocyte_physiolo1.19242148
69MP0001243_abnormal_dermal_layer1.18738871
70MP0005058_abnormal_lysosome_morphology1.18278006
71MP0002420_abnormal_adaptive_immunity1.17981974
72MP0002896_abnormal_bone_mineralization1.15707223
73MP0005248_abnormal_Harderian_gland1.13094125
74MP0004134_abnormal_chest_morphology1.11342449
75MP0003941_abnormal_skin_development1.11158406
76MP0008469_abnormal_protein_level1.11145259
77MP0000767_abnormal_smooth_muscle1.10005581
78MP0000163_abnormal_cartilage_morphology1.09209730
79MP0001800_abnormal_humoral_immune1.07562274
80MP0009053_abnormal_anal_canal1.07415157
81MP0003191_abnormal_cellular_cholesterol1.06921689
82MP0003045_fibrosis1.05778841
83MP0002115_abnormal_skeleton_extremities1.05375578
84MP0010368_abnormal_lymphatic_system1.04565397
85MP0002113_abnormal_skeleton_development1.04132892
86MP0002877_abnormal_melanocyte_morpholog1.03199234
87MP0005165_increased_susceptibility_to1.02521139
88MP0000733_abnormal_muscle_development1.02236499
89MP0009278_abnormal_bone_marrow1.00167098
90MP0003453_abnormal_keratinocyte_physiol0.99333184
91MP0001915_intracranial_hemorrhage0.96990733
92MP0010155_abnormal_intestine_physiology0.96273475
93MP0002332_abnormal_exercise_endurance0.93732093
94MP0000249_abnormal_blood_vessel0.93385092
95MP0000750_abnormal_muscle_regeneration0.91672384
96MP0009333_abnormal_splenocyte_physiolog0.90629537
97MP0010386_abnormal_urinary_bladder0.88111872
98MP0001542_abnormal_bone_strength0.86422325
99MP0005671_abnormal_response_to0.85727409
100MP0003385_abnormal_body_wall0.85115847
101MP0005171_absent_coat_pigmentation0.81772326
102MP0004808_abnormal_hematopoietic_stem0.81391895
103MP0008775_abnormal_heart_ventricle0.81374748
104MP0000762_abnormal_tongue_morphology0.81152343
105MP0005197_abnormal_uvea_morphology0.79379579
106MP0006054_spinal_hemorrhage0.76560535
107MP0000534_abnormal_ureter_morphology0.75942832
108MP0004084_abnormal_cardiac_muscle0.75147307
109MP0000003_abnormal_adipose_tissue0.74789974
110MP0002128_abnormal_blood_circulation0.74012622
111MP0009763_increased_sensitivity_to0.72135672
112MP0002060_abnormal_skin_morphology0.70958992
113MP0005397_hematopoietic_system_phenotyp0.70933803
114MP0001545_abnormal_hematopoietic_system0.70933803
115MP0005076_abnormal_cell_differentiation0.70686273
116MP0005167_abnormal_blood-brain_barrier0.70538121
117MP0001614_abnormal_blood_vessel0.69925012
118MP0000716_abnormal_immune_system0.69421483
119MP0000569_abnormal_digit_pigmentation0.68302686
120MP0000627_abnormal_mammary_gland0.68134681
121MP0001849_ear_inflammation0.66903164
122MP0005193_abnormal_anterior_eye0.65976783
123MP0002108_abnormal_muscle_morphology0.65971557
124MP0002925_abnormal_cardiovascular_devel0.64079855
125MP0004858_abnormal_nervous_system0.61941691
126MP0005375_adipose_tissue_phenotype0.61319206
127MP0001881_abnormal_mammary_gland0.59656517
128MP0000538_abnormal_urinary_bladder0.59284626
129MP0005451_abnormal_body_composition0.59004283
130MP0009697_abnormal_copulation0.57126889
131MP0001216_abnormal_epidermal_layer0.56788889

Predicted human phenotypes

RankGene SetZ-score
1Follicular hyperkeratosis (HP:0007502)6.17966270
2Eczematoid dermatitis (HP:0000976)5.52918669
3Recurrent gram-negative bacterial infections (HP:0005420)4.91575589
4Recurrent abscess formation (HP:0002722)4.90871946
5Protrusio acetabuli (HP:0003179)4.54893895
6Recurrent bacterial skin infections (HP:0005406)4.44054560
7Ankle contracture (HP:0006466)4.40829934
8Peritonitis (HP:0002586)4.30374729
9Premature rupture of membranes (HP:0001788)4.26607340
10Mediastinal lymphadenopathy (HP:0100721)3.88590148
11Stomatitis (HP:0010280)3.83858655
12Type 1 muscle fiber predominance (HP:0003803)3.82293295
13Vertebral compression fractures (HP:0002953)3.72165858
14Slender build (HP:0001533)3.56325773
15Bladder diverticulum (HP:0000015)3.41962176
16Abnormality of dentin (HP:0010299)3.38765218
17Abnormality of macrophages (HP:0004311)3.18970736
18Mitral valve prolapse (HP:0001634)3.18160213
19Spinal rigidity (HP:0003306)3.16803863
20Osteolytic defects of the hand bones (HP:0009699)3.09873686
21Osteolytic defects of the phalanges of the hand (HP:0009771)3.09873686
22Gingivitis (HP:0000230)3.05673247
23Interstitial pulmonary disease (HP:0006530)2.88136743
24Broad face (HP:0000283)2.82233191
25Elevated erythrocyte sedimentation rate (HP:0003565)2.81429856
26Atrophic scars (HP:0001075)2.79289378
27Shallow orbits (HP:0000586)2.78250132
28Fused cervical vertebrae (HP:0002949)2.78208008
29Overgrowth (HP:0001548)2.77949584
30Broad metatarsal (HP:0001783)2.76986019
31Aortic dissection (HP:0002647)2.68635370
32Autoimmune thrombocytopenia (HP:0001973)2.66443431
33Recurrent skin infections (HP:0001581)2.65337346
34Axonal loss (HP:0003447)2.64177274
35Cervical subluxation (HP:0003308)2.62594597
36Wormian bones (HP:0002645)2.62579903
37Joint laxity (HP:0001388)2.56627795
38Mitral stenosis (HP:0001718)2.54340037
39Hypoventilation (HP:0002791)2.54140319
40Hyperextensible skin (HP:0000974)2.53508209
41Dilatation of the ascending aorta (HP:0005111)2.53270573
42Abnormality of the phalanges of the 2nd finger (HP:0009541)2.53183576
43Mildly elevated creatine phosphokinase (HP:0008180)2.52628515
44Abnormality of the nasal septum (HP:0000419)2.49158174
45Alopecia of scalp (HP:0002293)2.48881576
46Increased neuronal autofluorescent lipopigment (HP:0002074)2.48432002
47Increased variability in muscle fiber diameter (HP:0003557)2.46480607
48Aortic regurgitation (HP:0001659)2.46023752
49Flared iliac wings (HP:0002869)2.45599773
50Abnormality of the parietal bone (HP:0002696)2.43228867
51Increased cerebral lipofuscin (HP:0011813)2.41299151
52Coxa vara (HP:0002812)2.38028516
53Aneurysm (HP:0002617)2.37854507
54Spinal cord lesions (HP:0100561)2.35819466
55Syringomyelia (HP:0003396)2.35819466
56Femoral bowing (HP:0002980)2.34580241
57Thin bony cortex (HP:0002753)2.33082087
58Obstructive lung disease (HP:0006536)2.32500313
59Chronic obstructive pulmonary disease (HP:0006510)2.32500313
60Abnormality of the pericardium (HP:0001697)2.31449022
61Cellulitis (HP:0100658)2.28766021
62Abnormality of glycosphingolipid metabolism (HP:0004343)2.27525157
63Abnormality of glycolipid metabolism (HP:0010969)2.27525157
64Abnormality of liposaccharide metabolism (HP:0010968)2.27525157
65Absent frontal sinuses (HP:0002688)2.27153196
66Limited elbow extension (HP:0001377)2.26594102
67Orchitis (HP:0100796)2.26193526
68Vitreoretinal degeneration (HP:0000655)2.25702292
69Aortic aneurysm (HP:0004942)2.25469176
70Biconcave vertebral bodies (HP:0004586)2.20398269
71Tibial bowing (HP:0002982)2.18614039
72Cardiovascular calcification (HP:0011915)2.17736265
73Basal ganglia calcification (HP:0002135)2.17236110
74Soft skin (HP:0000977)2.17028606
75Abnormality of the 2nd finger (HP:0004100)2.16768271
76Joint stiffness (HP:0001387)2.15927563
77Myocardial infarction (HP:0001658)2.15263374
78Ovoid vertebral bodies (HP:0003300)2.15054703
79Cupped ribs (HP:0000887)2.14773513
80Ectopia lentis (HP:0001083)2.13154737
81Neonatal short-limb short stature (HP:0008921)2.12552145
82Thick nail (HP:0001805)2.12274388
83Cerebral aneurysm (HP:0004944)2.11133834
84Wide anterior fontanel (HP:0000260)2.10736075
85Recurrent fungal infections (HP:0002841)2.10455645
86Renal duplication (HP:0000075)2.09109861
87Short 4th metacarpal (HP:0010044)2.07269665
88Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.07269665
89Abnormality of skeletal muscle fiber size (HP:0012084)2.05821658
90Myositis (HP:0100614)2.05350382
91Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)2.04742802
92Achilles tendon contracture (HP:0001771)2.04645832
93Spondylolisthesis (HP:0003302)2.02904023
94Abnormality of the acetabulum (HP:0003170)2.01986602
95Bowel diverticulosis (HP:0005222)2.00823628
96Abnormal delivery (HP:0001787)1.99411181
97Vascular tortuosity (HP:0004948)1.99170853
98Disproportionate tall stature (HP:0001519)1.96411299
99Thoracolumbar scoliosis (HP:0002944)1.95758593
100Osteoarthritis (HP:0002758)1.95391615
101Mesomelia (HP:0003027)1.94611770
102Blue sclerae (HP:0000592)1.93707658
103Dysostosis multiplex (HP:0000943)1.92864392
104Arterial tortuosity (HP:0005116)1.92608302
105Fragile skin (HP:0001030)1.92531369
106Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)1.92307356
107Poor head control (HP:0002421)1.92163039
108Ulnar bowing (HP:0003031)1.92043250
109Flat capital femoral epiphysis (HP:0003370)1.91985951
110Broad ribs (HP:0000885)1.91681681
111Mucopolysacchariduria (HP:0008155)1.90631780
112Urinary glycosaminoglycan excretion (HP:0003541)1.90631780
113Pulmonary infiltrates (HP:0002113)1.90447010
114Mitral regurgitation (HP:0001653)1.90371698
115Abnormality of mucopolysaccharide metabolism (HP:0011020)1.87347428
116Abnormality of polysaccharide metabolism (HP:0011012)1.87347428
117Abnormality of glycosaminoglycan metabolism (HP:0004371)1.87347428
118Broad hallux (HP:0010055)1.86883125
119Abnormality of the peritoneum (HP:0002585)1.86694291
120Disinhibition (HP:0000734)1.86673505
121Protruding ear (HP:0000411)1.86369350
122Short nail (HP:0001799)1.86333207
123Retrobulbar optic neuritis (HP:0100654)1.86219112
124Optic neuritis (HP:0100653)1.86219112
125Relative macrocephaly (HP:0004482)1.84609445
126Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.84237350
127Natal tooth (HP:0000695)1.83547238
128Pulmonary artery stenosis (HP:0004415)1.83154679
129Delayed closure of the anterior fontanelle (HP:0001476)1.82877868
130Genu recurvatum (HP:0002816)1.82760965
131Vacuolated lymphocytes (HP:0001922)1.81449178
132Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)1.80282962
133Systemic lupus erythematosus (HP:0002725)1.79975127
134Generalized amyotrophy (HP:0003700)1.79889099
135Inguinal hernia (HP:0000023)1.79875083
136Abnormality of the middle phalanges of the toes (HP:0010183)1.79836500
137Round ear (HP:0100830)1.79577863
138Pectus carinatum (HP:0000768)1.79315892
139Aortic valve stenosis (HP:0001650)1.78894915
140Abnormality of the Achilles tendon (HP:0005109)1.78836475
141Exostoses (HP:0100777)1.78662671
142Urticaria (HP:0001025)1.78571390
143Short middle phalanx of the 5th finger (HP:0004220)1.78236869
144Increased IgM level (HP:0003496)1.77793461
145Vasculitis (HP:0002633)1.77624113
146Periodontitis (HP:0000704)1.77515888
147Tetraparesis (HP:0002273)1.77396320
148Elbow flexion contracture (HP:0002987)1.76482945
149Bone pain (HP:0002653)1.75434145
150Epiphyseal dysplasia (HP:0002656)1.74976846
151Coronal craniosynostosis (HP:0004440)1.73829336
152Xerostomia (HP:0000217)1.73449449
153Recurrent pneumonia (HP:0006532)1.73028562
154Radial bowing (HP:0002986)1.72731316
155Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.72414959
156Short hallux (HP:0010109)1.72023106
157Redundant skin (HP:0001582)1.71347042
158Wrist flexion contracture (HP:0001239)1.71038995
159Nonimmune hydrops fetalis (HP:0001790)1.70798686
160Abnormality of the proximal phalanges of the hand (HP:0009834)1.70078336
161Abnormality of the frontal sinuses (HP:0002687)1.69785955
162Abnormality of oral frenula (HP:0000190)1.69448251
163Congenital glaucoma (HP:0001087)1.69441393

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PBK5.76039887
2BLK3.72774571
3RIPK43.50363817
4ERN13.21622886
5CLK12.90939962
6MAP3K142.87930661
7DDR22.72875023
8TBK12.41541066
9MST1R2.30976385
10BMX2.27657046
11AKT32.24881697
12TGFBR22.24284897
13PIM22.13223989
14TESK12.06669916
15JAK31.98202677
16NME21.98090914
17TTN1.97047750
18EPHB21.85764288
19ABL21.83783109
20NTRK11.83776083
21IKBKB1.81282792
22RPS6KA41.80488587
23CDC42BPA1.80465111
24ERBB31.79629174
25STK38L1.77832079
26PAK41.72206066
27TRPM71.54005406
28TXK1.49644835
29GRK71.46570917
30ERBB41.46093300
31STK241.45293733
32PRKD21.41327790
33LATS11.32325044
34IRAK31.30700222
35CSK1.28634847
36FLT31.28093139
37STK381.27364405
38STK101.24845611
39JAK11.19175649
40CHUK1.16931381
41PIK3CA1.16562922
42IKBKE1.16229982
43IRAK41.14112099
44LIMK11.13317895
45LATS21.11830234
46MAP3K51.09872258
47NEK91.09129088
48PIK3CG1.08374103
49LRRK21.04876110
50TAOK21.01544541
51EPHA31.00239954
52MAP3K110.99797380
53TYK20.99454267
54MET0.97869341
55PDGFRA0.97120921
56MARK30.96940933
57ADRBK20.90673038
58ARAF0.89957974
59HCK0.86658438
60SIK10.82431197
61MAP3K30.82053828
62LYN0.78218720
63MOS0.78059907
64NUAK10.77695800
65STK30.76706071
66MAP3K130.76591433
67EPHB10.75970267
68PTK2B0.74240170
69EGFR0.72983613
70MUSK0.72709179
71MAP2K30.72439769
72RIPK10.70920410
73PLK20.70626805
74BMPR1B0.70236692
75PAK30.70053148
76MST40.69975893
77PDGFRB0.68290254
78ABL10.67913802
79DAPK30.67235547
80PIM10.66616891
81STK40.66292367
82TIE10.65826440
83BMPR20.65509604
84MATK0.63896127
85ROCK20.63766748
86PRKCD0.63632011
87LMTK20.63335262
88ILK0.63196840
89MAP3K90.61727201
90PAK20.60004311
91EPHA20.59102582
92INSR0.58726585
93GSK3A0.58425813
94LCK0.57800039
95MYLK0.57706260
96FGR0.57632690
97MTOR0.56753843
98PTK20.56139652
99CDK60.55514466
100KIT0.55193410
101ADRBK10.54819374
102TRIB30.52566462
103RPS6KA20.52494825
104SIK30.52005218
105EIF2AK20.51369799
106ZAP700.50892882
107IGF1R0.48830001
108MAP3K60.48728778
109FGFR40.48343348
110SYK0.48027838
111MAP3K120.47603068
112PRKG20.47449766
113MAPK70.46217852
114ROCK10.46004784
115MELK0.43348906
116MAP3K20.42639566
117PRPF4B0.41751755
118TAOK10.41299009
119JAK20.40940098
120WNK10.40930410
121YES10.40780923
122MAP3K10.39627893
123FYN0.39592313
124NLK0.37539573
125CDK90.37202366
126PRKCQ0.36379712
127PRKCE0.36256459
128FGFR10.34715225
129DMPK0.33924561
130FER0.33673840
131MAPK40.33077912
132CDK120.29500449
133FGFR30.28819256
134PAK60.27299266
135PRKD10.23992555
136SRC0.22981558

Predicted pathways (KEGG)

RankGene SetZ-score
1Graft-versus-host disease_Homo sapiens_hsa053323.75581444
2Leishmaniasis_Homo sapiens_hsa051403.42875417
3Malaria_Homo sapiens_hsa051442.89510592
4Legionellosis_Homo sapiens_hsa051342.80010908
5Rheumatoid arthritis_Homo sapiens_hsa053232.77513730
6Type I diabetes mellitus_Homo sapiens_hsa049402.53065834
7Toll-like receptor signaling pathway_Homo sapiens_hsa046202.41469266
8Salmonella infection_Homo sapiens_hsa051322.40350240
9Pertussis_Homo sapiens_hsa051332.33761258
10NOD-like receptor signaling pathway_Homo sapiens_hsa046212.27993085
11TNF signaling pathway_Homo sapiens_hsa046682.26250305
12Staphylococcus aureus infection_Homo sapiens_hsa051502.22668705
13NF-kappa B signaling pathway_Homo sapiens_hsa040642.21927380
14Allograft rejection_Homo sapiens_hsa053302.15917985
15Tuberculosis_Homo sapiens_hsa051522.12190592
16Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.07977568
17Phagosome_Homo sapiens_hsa041452.00033823
18Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.98918113
19Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.97162670
20Osteoclast differentiation_Homo sapiens_hsa043801.91767612
21Asthma_Homo sapiens_hsa053101.83328860
22Amoebiasis_Homo sapiens_hsa051461.68709590
23* Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.67639629
24AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.67334726
25Hematopoietic cell lineage_Homo sapiens_hsa046401.60795488
26Shigellosis_Homo sapiens_hsa051311.59767184
27African trypanosomiasis_Homo sapiens_hsa051431.59151500
28Measles_Homo sapiens_hsa051621.51729822
29RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.48349402
30ECM-receptor interaction_Homo sapiens_hsa045121.45080269
31Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.36495925
32Toxoplasmosis_Homo sapiens_hsa051451.31993209
33Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.27151635
34Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.26547278
35Influenza A_Homo sapiens_hsa051641.25602018
36Proteoglycans in cancer_Homo sapiens_hsa052051.23898677
37Complement and coagulation cascades_Homo sapiens_hsa046101.23314985
38Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.18145719
39Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.16770316
40Lysosome_Homo sapiens_hsa041421.16507837
41Prion diseases_Homo sapiens_hsa050201.13933113
42Apoptosis_Homo sapiens_hsa042101.07064152
43Leukocyte transendothelial migration_Homo sapiens_hsa046701.04362437
44Hepatitis B_Homo sapiens_hsa051611.03189901
45Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.02705266
46Dorso-ventral axis formation_Homo sapiens_hsa043201.02160891
47Chemokine signaling pathway_Homo sapiens_hsa040621.01534064
48Focal adhesion_Homo sapiens_hsa045100.99472306
49* TGF-beta signaling pathway_Homo sapiens_hsa043500.96545565
50Viral myocarditis_Homo sapiens_hsa054160.95955992
51Intestinal immune network for IgA production_Homo sapiens_hsa046720.92918211
52Sulfur metabolism_Homo sapiens_hsa009200.92251846
53Adherens junction_Homo sapiens_hsa045200.91351406
54Sphingolipid metabolism_Homo sapiens_hsa006000.89527622
55Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.87535188
56Jak-STAT signaling pathway_Homo sapiens_hsa046300.86691956
57Small cell lung cancer_Homo sapiens_hsa052220.85385947
58Regulation of actin cytoskeleton_Homo sapiens_hsa048100.82277980
59Renal cell carcinoma_Homo sapiens_hsa052110.80476388
60Platelet activation_Homo sapiens_hsa046110.80445172
61Herpes simplex infection_Homo sapiens_hsa051680.77507255
62Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.71766698
63MicroRNAs in cancer_Homo sapiens_hsa052060.71344220
64Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.70335330
65Chronic myeloid leukemia_Homo sapiens_hsa052200.67643788
66Glioma_Homo sapiens_hsa052140.67418099
67B cell receptor signaling pathway_Homo sapiens_hsa046620.65606343
68Vibrio cholerae infection_Homo sapiens_hsa051100.65029508
69Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.64799116
70Collecting duct acid secretion_Homo sapiens_hsa049660.64258967
71GnRH signaling pathway_Homo sapiens_hsa049120.63451696
72Bladder cancer_Homo sapiens_hsa052190.62826923
73Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.61310098
74Autoimmune thyroid disease_Homo sapiens_hsa053200.61138574
75Endocytosis_Homo sapiens_hsa041440.58587591
76HIF-1 signaling pathway_Homo sapiens_hsa040660.55701477
77Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.55596034
78Phospholipase D signaling pathway_Homo sapiens_hsa040720.54567138
79ErbB signaling pathway_Homo sapiens_hsa040120.53353446
80Neurotrophin signaling pathway_Homo sapiens_hsa047220.53026814
81Melanoma_Homo sapiens_hsa052180.52858746
82Mineral absorption_Homo sapiens_hsa049780.51207539
83N-Glycan biosynthesis_Homo sapiens_hsa005100.50979146
84FoxO signaling pathway_Homo sapiens_hsa040680.49533139
85Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.49501341
86PI3K-Akt signaling pathway_Homo sapiens_hsa041510.48685699
87Hedgehog signaling pathway_Homo sapiens_hsa043400.48180293
88Central carbon metabolism in cancer_Homo sapiens_hsa052300.46446062
89Adipocytokine signaling pathway_Homo sapiens_hsa049200.45831776
90Dilated cardiomyopathy_Homo sapiens_hsa054140.45481667
91Thyroid cancer_Homo sapiens_hsa052160.45396443
92Rap1 signaling pathway_Homo sapiens_hsa040150.45206347
93Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.43574538
94Pancreatic cancer_Homo sapiens_hsa052120.42617472
95Ras signaling pathway_Homo sapiens_hsa040140.41382652
96Hepatitis C_Homo sapiens_hsa051600.40679613
97Vascular smooth muscle contraction_Homo sapiens_hsa042700.40485512
98Acute myeloid leukemia_Homo sapiens_hsa052210.40277468
99HTLV-I infection_Homo sapiens_hsa051660.40223229
100Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.40222178
101Other glycan degradation_Homo sapiens_hsa005110.40147927
102Insulin resistance_Homo sapiens_hsa049310.39466005
103Axon guidance_Homo sapiens_hsa043600.37724814
104Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.36884578
105SNARE interactions in vesicular transport_Homo sapiens_hsa041300.36010678
106Ovarian steroidogenesis_Homo sapiens_hsa049130.35747403
107Pathways in cancer_Homo sapiens_hsa052000.34949847
108Antigen processing and presentation_Homo sapiens_hsa046120.33941370
109Hippo signaling pathway_Homo sapiens_hsa043900.32491330
110Prolactin signaling pathway_Homo sapiens_hsa049170.32423688
111Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.31183960
112Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.30770422
113p53 signaling pathway_Homo sapiens_hsa041150.29495669
114T cell receptor signaling pathway_Homo sapiens_hsa046600.28919151
115VEGF signaling pathway_Homo sapiens_hsa043700.28774041
116Basal cell carcinoma_Homo sapiens_hsa052170.28364752
117Glycosaminoglycan degradation_Homo sapiens_hsa005310.28178584
118Sphingolipid signaling pathway_Homo sapiens_hsa040710.26856628
119Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.26845406
120MAPK signaling pathway_Homo sapiens_hsa040100.25547054
121Prostate cancer_Homo sapiens_hsa052150.25337399
122Steroid biosynthesis_Homo sapiens_hsa001000.24257305
123Viral carcinogenesis_Homo sapiens_hsa052030.23610715
124Protein digestion and absorption_Homo sapiens_hsa049740.22888736

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