INHBB

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the TGF-beta (transforming growth factor-beta) superfamily of proteins. The encoded preproprotein is proteolytically processed to generate a subunit of the dimeric activin and inhibin protein complexes. These complexes activate and inhibit, respectively, follicle stimulating hormone secretion from the pituitary gland. Polymorphisms near this gene are associated with pre-eclampsia in female human patients. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of T cell differentiation in thymus (GO:0033089)9.77833089
2somite development (GO:0061053)9.30263322
3embryonic eye morphogenesis (GO:0048048)8.84948309
4gonadal mesoderm development (GO:0007506)8.59495330
5negative regulation of alpha-beta T cell differentiation (GO:0046639)8.54046790
6embryonic camera-type eye morphogenesis (GO:0048596)8.03372615
7extracellular matrix assembly (GO:0085029)7.60769424
8cardiac right ventricle morphogenesis (GO:0003215)6.83531990
9smooth muscle tissue development (GO:0048745)6.73149250
10positive regulation of chondrocyte differentiation (GO:0032332)6.40236877
11endothelial cell chemotaxis (GO:0035767)6.32456877
12estrogen biosynthetic process (GO:0006703)6.26789912
13embryonic digestive tract morphogenesis (GO:0048557)5.75491834
14positive regulation of male gonad development (GO:2000020)5.65897313
15sex determination (GO:0007530)5.39829834
16regulation of developmental pigmentation (GO:0048070)5.32380414
17positive regulation of collagen biosynthetic process (GO:0032967)5.09599739
18regulation of male gonad development (GO:2000018)4.87782352
19protein heterotrimerization (GO:0070208)4.84827537
20positive regulation of smoothened signaling pathway (GO:0045880)4.83873266
21positive regulation of collagen metabolic process (GO:0010714)4.82114837
22basement membrane organization (GO:0071711)4.82048476
23positive regulation of cartilage development (GO:0061036)4.67142953
24androgen biosynthetic process (GO:0006702)4.55854006
25hemidesmosome assembly (GO:0031581)4.51825244
26eye morphogenesis (GO:0048592)4.48727693
27bone resorption (GO:0045453)4.44521889
28glomerular basement membrane development (GO:0032836)4.29259280
29proteoglycan metabolic process (GO:0006029)4.25874673
30regulation of T cell differentiation in thymus (GO:0033081)4.23497693
31negative regulation of alpha-beta T cell activation (GO:0046636)4.20273015
32regulation of collagen biosynthetic process (GO:0032965)4.14830028
33vitamin A metabolic process (GO:0006776)4.11659244
34apoptotic cell clearance (GO:0043277)4.10650724
35anatomical structure regression (GO:0060033)4.00277169
36urogenital system development (GO:0001655)4.00201315
37atrial septum morphogenesis (GO:0060413)3.97268349
38cell migration involved in sprouting angiogenesis (GO:0002042)3.91616888
39cellular response to follicle-stimulating hormone stimulus (GO:0071372)3.86320391
40negative regulation of lymphocyte differentiation (GO:0045620)3.86064935
41Leydig cell differentiation (GO:0033327)3.85736953
42renal filtration (GO:0097205)3.83409635
43collagen fibril organization (GO:0030199)3.75913530
44glomerular filtration (GO:0003094)3.74351859
45adhesion of symbiont to host (GO:0044406)3.71825978
46response to follicle-stimulating hormone (GO:0032354)3.71757231
47chondrocyte proliferation (GO:0035988)3.62967867
48epithelial cell fate commitment (GO:0072148)3.61367152
49seminiferous tubule development (GO:0072520)3.54866750
50regulation of collagen metabolic process (GO:0010712)3.53983404
51epithelial cell-cell adhesion (GO:0090136)3.52521462
52maternal process involved in female pregnancy (GO:0060135)3.51962640
53regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.51887380
54cardiac muscle tissue development (GO:0048738)3.47583330
55endodermal cell differentiation (GO:0035987)3.46887937
56galactose metabolic process (GO:0006012)3.46617259
57estrogen metabolic process (GO:0008210)3.45759200
58female gonad development (GO:0008585)3.44855773
59* ovulation cycle process (GO:0022602)3.44514799
60positive regulation of mesenchymal cell proliferation (GO:0002053)3.44273790
61cellular response to interferon-alpha (GO:0035457)3.43772665
62cardiac muscle hypertrophy in response to stress (GO:0014898)3.43205747
63muscle hypertrophy in response to stress (GO:0003299)3.43205747
64cardiac muscle adaptation (GO:0014887)3.43205747
65positive regulation of multicellular organismal metabolic process (GO:0044253)3.40006790
66pancreas development (GO:0031016)3.39857018
67patterning of blood vessels (GO:0001569)3.38294330
68regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.38165543
69skin morphogenesis (GO:0043589)3.36552643
70negative regulation of macrophage differentiation (GO:0045650)3.35852976
71* regulation of gonadotropin secretion (GO:0032276)3.34987403
72negative regulation of T cell differentiation (GO:0045581)3.33059210
73blood vessel endothelial cell migration (GO:0043534)3.29402062
74polarized epithelial cell differentiation (GO:0030859)3.26771981
75collagen metabolic process (GO:0032963)3.22118685
76positive regulation of endothelial cell apoptotic process (GO:2000353)3.22100720
77cartilage development involved in endochondral bone morphogenesis (GO:0060351)3.21392289
78cell-substrate junction assembly (GO:0007044)3.20329872
79collagen catabolic process (GO:0030574)3.16708338
80cardiac ventricle morphogenesis (GO:0003208)3.15490974
81hemoglobin metabolic process (GO:0020027)3.14803095
82epithelial cell morphogenesis (GO:0003382)3.14591833
83glial cell proliferation (GO:0014009)3.12013925
84cellular response to cadmium ion (GO:0071276)3.10629409
85type B pancreatic cell proliferation (GO:0044342)3.08909748
86multicellular organismal macromolecule metabolic process (GO:0044259)3.07923042
87regulation of chondrocyte differentiation (GO:0032330)3.03956534
88labyrinthine layer blood vessel development (GO:0060716)3.03400711
89regulation of cell proliferation involved in kidney development (GO:1901722)3.02913451
90extracellular matrix disassembly (GO:0022617)3.01197098
91ovulation from ovarian follicle (GO:0001542)3.00160314
92* ovarian follicle development (GO:0001541)3.00040853
93dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.99350281
94retina vasculature morphogenesis in camera-type eye (GO:0061299)2.98902946
95embryonic skeletal system development (GO:0048706)2.97168684
96hippo signaling (GO:0035329)2.96982490
97embryonic foregut morphogenesis (GO:0048617)2.95212250
98negative regulation of fatty acid transport (GO:2000192)2.94261310
99heart valve morphogenesis (GO:0003179)2.94239079
100dermatan sulfate biosynthetic process (GO:0030208)2.94238608
101cell adhesion mediated by integrin (GO:0033627)2.92304283
102endothelial cell morphogenesis (GO:0001886)2.91384273
103multicellular organismal catabolic process (GO:0044243)2.91380744
104regulation of mesenchymal cell proliferation (GO:0010464)2.91016275
105dermatan sulfate metabolic process (GO:0030205)2.90229122
106multicellular organismal metabolic process (GO:0044236)2.90147095
107cardiac chamber morphogenesis (GO:0003206)2.87717849
108ventricular septum development (GO:0003281)2.87626902
109negative regulation of smooth muscle cell migration (GO:0014912)2.86558801
110cellular response to growth hormone stimulus (GO:0071378)2.83541118
111cytoskeletal anchoring at plasma membrane (GO:0007016)2.82472965
112endocardial cushion development (GO:0003197)2.82206849
113regulation of transforming growth factor beta2 production (GO:0032909)2.82140460
114branching involved in salivary gland morphogenesis (GO:0060445)2.79228648
115neuron fate commitment (GO:0048663)2.76488577
116negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)2.75827913
117sex differentiation (GO:0007548)2.75229242
118chondroitin sulfate biosynthetic process (GO:0030206)2.74255160
119negative regulation of chondrocyte differentiation (GO:0032331)2.74045479
120regulation of hippo signaling (GO:0035330)2.73497536
121cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.73199498
122male sex determination (GO:0030238)2.71959714
123mating behavior (GO:0007617)2.71792909
124adherens junction assembly (GO:0034333)2.71052471
125regulation of cardioblast differentiation (GO:0051890)2.70851427
126regulation of tight junction assembly (GO:2000810)2.70816815
127establishment of apical/basal cell polarity (GO:0035089)2.69198631
128drug transmembrane transport (GO:0006855)2.69056311
129response to food (GO:0032094)2.67831118
130regulation of interferon-gamma biosynthetic process (GO:0045072)2.67715771
131virion attachment to host cell (GO:0019062)2.67290567
132adhesion of symbiont to host cell (GO:0044650)2.67290567
133regulation of cardiac muscle cell contraction (GO:0086004)2.67052536
134substrate adhesion-dependent cell spreading (GO:0034446)2.66799862
135glycosaminoglycan biosynthetic process (GO:0006024)2.65853024
136stress fiber assembly (GO:0043149)2.65644887
137heart valve formation (GO:0003188)2.65461439
138cellular response to vitamin (GO:0071295)2.65116331
139low-density lipoprotein particle clearance (GO:0034383)2.61776308
140protein localization to cell surface (GO:0034394)2.61757735
141paraxial mesoderm development (GO:0048339)2.61131086
142ovulation cycle (GO:0042698)2.60957211
143growth hormone receptor signaling pathway (GO:0060396)2.59649211
144response to gonadotropin (GO:0034698)2.59476807
145regulation of SMAD protein import into nucleus (GO:0060390)2.57740426
146male genitalia development (GO:0030539)2.57680978
147atrioventricular valve morphogenesis (GO:0003181)2.56728162
148sequestering of extracellular ligand from receptor (GO:0035581)2.56280964
149negative regulation of complement activation (GO:0045916)2.54481839
150lymphangiogenesis (GO:0001946)2.53765405
151fibroblast migration (GO:0010761)2.53445382
152regulation of glomerular filtration (GO:0003093)2.53339829
153cellular response to gonadotropin stimulus (GO:0071371)2.52604380
154positive regulation of macrophage activation (GO:0043032)2.51985339
155peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)2.51556100
156wound healing, spreading of epidermal cells (GO:0035313)2.49220763
157vascular endothelial growth factor signaling pathway (GO:0038084)2.48680859
158positive regulation of osteoblast proliferation (GO:0033690)2.48247518
159negative regulation of cartilage development (GO:0061037)2.48216340
160positive regulation of p38MAPK cascade (GO:1900745)2.46788617
161regulation of macrophage cytokine production (GO:0010935)2.44634335
162gastrulation with mouth forming second (GO:0001702)2.44150497
163decidualization (GO:0046697)2.42733953
164renal system development (GO:0072001)2.42631652
165blood vessel maturation (GO:0001955)2.41305837
166epithelial cell differentiation involved in prostate gland development (GO:0060742)2.40221209
167regulation of female gonad development (GO:2000194)2.38711207
168glucocorticoid biosynthetic process (GO:0006704)2.38089580
169negative regulation of T cell differentiation in thymus (GO:0033085)12.3308783

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human6.39040594
2THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse4.83880626
3TRIM28_21343339_ChIP-Seq_HEK293_Human4.20465995
4CLOCK_20551151_ChIP-Seq_293T_Human3.77899059
5RARG_19884340_ChIP-ChIP_MEFs_Mouse3.00880186
6STAT6_21828071_ChIP-Seq_BEAS2B_Human3.00766283
7NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.95185434
8ZNF263_19887448_ChIP-Seq_K562_Human2.64362965
9ESR1_21235772_ChIP-Seq_MCF-7_Human2.55526963
10ESR1_15608294_ChIP-ChIP_MCF-7_Human2.49557516
11HIF1A_21447827_ChIP-Seq_MCF-7_Human2.39776149
12TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.39092983
13TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.13610365
14ESR2_21235772_ChIP-Seq_MCF-7_Human2.12746387
15NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.11259053
16* ESR1_22446102_ChIP-Seq_UTERUS_Mouse2.09894358
17* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse2.09219811
18STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.01814552
19PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.00009376
20TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.99639859
21BP1_19119308_ChIP-ChIP_Hs578T_Human1.96535592
22RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.91470082
23EZH2_27304074_Chip-Seq_ESCs_Mouse1.83603415
24MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.81275099
25EED_16625203_ChIP-ChIP_MESCs_Mouse1.80988070
26ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.79255340
27JARID2_20075857_ChIP-Seq_MESCs_Mouse1.78295836
28* RNF2_27304074_Chip-Seq_ESCs_Mouse1.75930315
29* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.75065884
30EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.70884216
31SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.69884134
32CJUN_26792858_Chip-Seq_BT549_Human1.69078015
33EZH2_27294783_Chip-Seq_ESCs_Mouse1.67753050
34* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.66894811
35* TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.66785284
36SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.66055705
37* SOX9_24532713_ChIP-Seq_HFSC_Mouse1.65442749
38PPAR_26484153_Chip-Seq_NCI-H1993_Human1.63870861
39SOX2_27498859_Chip-Seq_STOMACH_Mouse1.62412505
40KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.62183212
41KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.62183212
42KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.62183212
43TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.57968657
44* RING1B_27294783_Chip-Seq_NPCs_Mouse1.55381253
45PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.54912187
46KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.54259942
47CBX2_27304074_Chip-Seq_ESCs_Mouse1.54001554
48CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.52965019
49FOXO3_23340844_ChIP-Seq_DLD1_Human1.52193902
50KDM2B_26808549_Chip-Seq_K562_Human1.52093578
51SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.52056036
52EGR1_19374776_ChIP-ChIP_THP-1_Human1.49120596
53FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.49049036
54SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.48330721
55SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.48330721
56* ELK3_25401928_ChIP-Seq_HUVEC_Human1.47753087
57P300_27058665_Chip-Seq_ZR-75-30cells_Human1.47292753
58POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.46483261
59* RACK7_27058665_Chip-Seq_MCF-7_Human1.45726445
60ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.44674686
61ZNF217_24962896_ChIP-Seq_MCF-7_Human1.44452813
62ESR1_20079471_ChIP-ChIP_T-47D_Human1.44437834
63ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.43953190
64SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.42438782
65HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.42234022
66* SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.41234429
67KDM2B_26808549_Chip-Seq_SUP-B15_Human1.40480387
68UBF1/2_26484160_Chip-Seq_HMECs_Human1.37725591
69* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.37184313
70RXR_22158963_ChIP-Seq_LIVER_Mouse1.37061021
71ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.35722671
72PPARA_22158963_ChIP-Seq_LIVER_Mouse1.34957367
73SALL4_18804426_ChIP-ChIP_XEN_Mouse1.32436791
74ATF3_27146783_Chip-Seq_COLON_Human1.31413860
75SA1_27219007_Chip-Seq_ERYTHROID_Human1.30537354
76* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.30014110
77UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.28257059
78* RUNX1_27514584_Chip-Seq_MCF-7_Human1.27259586
79BRD4_25478319_ChIP-Seq_HGPS_Human1.26576582
80KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.24471051
81SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.24057537
82* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.23749954
83KDM2B_26808549_Chip-Seq_DND41_Human1.23540887
84CTCF_27219007_Chip-Seq_ERYTHROID_Human1.22834187
85* DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.22815770
86EP300_21415370_ChIP-Seq_HL-1_Mouse1.21939110
87ISL1_27105846_Chip-Seq_CPCs_Mouse1.20846112
88ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.19497358
89TP53_20018659_ChIP-ChIP_R1E_Mouse1.18824889
90TCF3_18692474_ChIP-Seq_MEFs_Mouse1.18615488
91TBX20_22080862_ChIP-Seq_HEART_Mouse1.18219387
92TBX20_22328084_ChIP-Seq_HEART_Mouse1.18219387
93SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.18180671
94* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.17892142
95* JARID2_20064375_ChIP-Seq_MESCs_Mouse1.16675039
96* SOX2_20726797_ChIP-Seq_SW620_Human1.14719997
97* JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse1.11708004
98KDM2B_26808549_Chip-Seq_JURKAT_Human1.09442908
99ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.08172643
100CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.08097119
101BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.07887419
102SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.07337413
103ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.07011322
104LXR_22292898_ChIP-Seq_THP-1_Human1.06978653
105* EZH2_18974828_ChIP-Seq_MESCs_Mouse1.06541499
106* RNF2_18974828_ChIP-Seq_MESCs_Mouse1.06541499
107LXR_22158963_ChIP-Seq_LIVER_Mouse1.06530579
108TP53_16413492_ChIP-PET_HCT116_Human1.06303530
109RAD21_21589869_ChIP-Seq_MESCs_Mouse1.05158170
110CTCF_27219007_Chip-Seq_Bcells_Human1.04974402
111* SA1_22415368_ChIP-Seq_MEFs_Mouse1.04857651
112NFIB_24661679_ChIP-Seq_LUNG_Mouse1.04551742
113* SMC1_22415368_ChIP-Seq_MEFs_Mouse1.04318757
114KLF5_25053715_ChIP-Seq_YYC3_Human1.04019534
115* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.03773825
116GATA2_21666600_ChIP-Seq_HMVEC_Human1.02754227
117CDX2_19796622_ChIP-Seq_MESCs_Mouse1.02374382
118WT1_19549856_ChIP-ChIP_CCG9911_Human1.01600009
119* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.01496019
120MYC_27129775_Chip-Seq_CORNEA_Mouse1.00852485
121ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.00626289
122P63_26484246_Chip-Seq_KERATINOCYTES_Human1.00278484
123* RING1B_27294783_Chip-Seq_ESCs_Mouse1.00083722
124FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.99474659
125* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.98471751
126* CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.98040527
127* AHR_22903824_ChIP-Seq_MCF-7_Human0.97343991
128ERG_21242973_ChIP-ChIP_JURKAT_Human0.97114482
129EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.96205705
130KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.96061449
131SALL1_21062744_ChIP-ChIP_HESCs_Human0.95815167
132IKZF1_21737484_ChIP-ChIP_HCT116_Human0.95672774
133TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.95662667
134* GATA3_24758297_ChIP-Seq_MCF-7_Human0.95030538
135* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.94854259
136CDX2_20551321_ChIP-Seq_CACO-2_Human0.94638285
137TET1_21490601_ChIP-Seq_MESCs_Mouse0.93722142
138KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.92600080
139CREB1_26743006_Chip-Seq_LNCaP_Human0.91496994
140TP53_22127205_ChIP-Seq_IMR90_Human0.89923393
141ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.89210282
142* SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.88248451

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen5.69117317
2MP0003705_abnormal_hypodermis_morpholog4.04303199
3MP0005275_abnormal_skin_tensile3.71030742
4MP0004272_abnormal_basement_membrane3.51805362
5MP0004233_abnormal_muscle_weight3.27449343
6MP0002254_reproductive_system_inflammat3.17219967
7MP0005503_abnormal_tendon_morphology3.01674116
8MP0000462_abnormal_digestive_system2.92100599
9MP0005623_abnormal_meninges_morphology2.90924815
10MP0010234_abnormal_vibrissa_follicle2.72036176
11MP0006054_spinal_hemorrhage2.63941935
12MP0001958_emphysema2.62402847
13MP0009384_cardiac_valve_regurgitation2.50884177
14MP0003011_delayed_dark_adaptation2.48623501
15MP0003566_abnormal_cell_adhesion2.47795096
16MP0003279_aneurysm2.44923758
17MP0008875_abnormal_xenobiotic_pharmacok2.39064694
18MP0002822_catalepsy2.38076197
19MP0008995_early_reproductive_senescence2.19431687
20MP0003045_fibrosis2.18762680
21MP0001661_extended_life_span2.09177976
22MP0009250_abnormal_appendicular_skeleto1.79354402
23MP0005248_abnormal_Harderian_gland1.71828850
24MP0004145_abnormal_muscle_electrophysio1.69686945
25MP0005076_abnormal_cell_differentiation1.66671173
26MP0002060_abnormal_skin_morphology1.65432891
27MP0003091_abnormal_cell_migration1.64643731
28MP0002168_other_aberrant_phenotype1.63882582
29MP0010368_abnormal_lymphatic_system1.57721163
30MP0005670_abnormal_white_adipose1.54024125
31MP0004084_abnormal_cardiac_muscle1.43775259
32MP0005023_abnormal_wound_healing1.41705799
33MP0010352_gastrointestinal_tract_polyps1.40160503
34MP0001849_ear_inflammation1.38438617
35MP0005508_abnormal_skeleton_morphology1.37552508
36MP0002896_abnormal_bone_mineralization1.37339270
37MP0003300_gastrointestinal_ulcer1.36371255
38MP0000537_abnormal_urethra_morphology1.33597052
39MP0005647_abnormal_sex_gland1.33297476
40MP0000751_myopathy1.33104707
41MP0003878_abnormal_ear_physiology1.33022144
42MP0005377_hearing/vestibular/ear_phenot1.33022144
43MP0004858_abnormal_nervous_system1.32026854
44MP0003828_pulmonary_edema1.29817789
45MP0002282_abnormal_trachea_morphology1.29005774
46MP0000733_abnormal_muscle_development1.27420722
47MP0003315_abnormal_perineum_morphology1.26533569
48MP0003115_abnormal_respiratory_system1.25839792
49MP0005187_abnormal_penis_morphology1.25730552
50MP0000013_abnormal_adipose_tissue1.25448712
51MP0000566_synostosis1.21861868
52MP0000750_abnormal_muscle_regeneration1.20979847
53MP0002108_abnormal_muscle_morphology1.20970709
54MP0009278_abnormal_bone_marrow1.19198273
55MP0001879_abnormal_lymphatic_vessel1.18937876
56MP0002796_impaired_skin_barrier1.18382920
57MP0000767_abnormal_smooth_muscle1.16722203
58MP0010678_abnormal_skin_adnexa1.15546529
59MP0003941_abnormal_skin_development1.15540225
60MP0002877_abnormal_melanocyte_morpholog1.12436588
61MP0005395_other_phenotype1.12391362
62MP0000534_abnormal_ureter_morphology1.11769731
63MP0003283_abnormal_digestive_organ1.10598984
64MP0000428_abnormal_craniofacial_morphol1.10288575
65MP0003195_calcinosis1.09601486
66MP0002295_abnormal_pulmonary_circulatio1.09512072
67MP0004185_abnormal_adipocyte_glucose1.08405240
68MP0003936_abnormal_reproductive_system1.07563683
69MP0000003_abnormal_adipose_tissue1.06458084
70MP0004019_abnormal_vitamin_homeostasis1.06008063
71* MP0001881_abnormal_mammary_gland1.03510405
72MP0005375_adipose_tissue_phenotype1.01481510
73MP0003385_abnormal_body_wall0.99140744
74MP0004883_abnormal_blood_vessel0.99087202
75MP0009053_abnormal_anal_canal0.98604575
76MP0003942_abnormal_urinary_system0.98002507
77MP0005666_abnormal_adipose_tissue0.97387663
78MP0002751_abnormal_autonomic_nervous0.95986311
79MP0000467_abnormal_esophagus_morphology0.95017117
80MP0000639_abnormal_adrenal_gland0.93802274
81MP0003453_abnormal_keratinocyte_physiol0.93310748
82MP0009780_abnormal_chondrocyte_physiolo0.92338570
83MP0002089_abnormal_postnatal_growth/wei0.91668426
84MP0004782_abnormal_surfactant_physiolog0.89874226
85MP0006138_congestive_heart_failure0.89648783
86MP0003786_premature_aging0.86644255
87MP0001915_intracranial_hemorrhage0.85441572
88* MP0000627_abnormal_mammary_gland0.85090324
89MP0002909_abnormal_adrenal_gland0.83365575
90MP0001529_abnormal_vocalization0.82584265
91MP0000383_abnormal_hair_follicle0.82332893
92MP0000647_abnormal_sebaceous_gland0.82143770
93MP0000858_altered_metastatic_potential0.81984701
94MP0010030_abnormal_orbit_morphology0.81907769
95MP0005164_abnormal_response_to0.81020326
96MP0000427_abnormal_hair_cycle0.80895686
97MP0002128_abnormal_blood_circulation0.80394680
98MP0003448_altered_tumor_morphology0.78110673
99MP0002925_abnormal_cardiovascular_devel0.77145593
100MP0004036_abnormal_muscle_relaxation0.77008565
101MP0002127_abnormal_cardiovascular_syste0.76895921
102MP0002115_abnormal_skeleton_extremities0.76537590
103MP0005501_abnormal_skin_physiology0.76521134
104MP0005167_abnormal_blood-brain_barrier0.76038081
105MP0000163_abnormal_cartilage_morphology0.75335648
106MP0003935_abnormal_craniofacial_develop0.74682148
107MP0000762_abnormal_tongue_morphology0.73363913
108MP0001614_abnormal_blood_vessel0.72961555
109MP0001243_abnormal_dermal_layer0.72303418
110MP0005389_reproductive_system_phenotype0.72225756
111MP0005390_skeleton_phenotype0.71690531
112MP0003567_abnormal_fetal_cardiomyocyte0.71150038
113MP0004885_abnormal_endolymph0.70913834
114MP0003755_abnormal_palate_morphology0.70479100
115MP0001919_abnormal_reproductive_system0.69094484
116* MP0001340_abnormal_eyelid_morphology0.69030737
117MP0002697_abnormal_eye_size0.68393574
118MP0004197_abnormal_fetal_growth/weight/0.66038965
119MP0005409_darkened_coat_color0.65793281
120MP0002932_abnormal_joint_morphology0.65475774
121MP0003937_abnormal_limbs/digits/tail_de0.64084101
122MP0000538_abnormal_urinary_bladder0.63921883
123MP0001730_embryonic_growth_arrest0.62139542
124MP0010329_abnormal_lipoprotein_level0.60888194
125MP0002098_abnormal_vibrissa_morphology0.59698975
126MP0003221_abnormal_cardiomyocyte_apopto0.59472893
127MP0002111_abnormal_tail_morphology0.59028013
128MP0005085_abnormal_gallbladder_physiolo0.58676503
129MP0003632_abnormal_nervous_system0.58636286
130MP0002933_joint_inflammation0.57621802
131MP0003795_abnormal_bone_structure0.56140658
132MP0002114_abnormal_axial_skeleton0.54989822
133MP0002113_abnormal_skeleton_development0.52423568
134MP0001145_abnormal_male_reproductive0.51573610
135MP0003634_abnormal_glial_cell0.50442637
136MP0002160_abnormal_reproductive_system0.49105447
137MP0005058_abnormal_lysosome_morphology0.48872784
138MP0002109_abnormal_limb_morphology0.48571607
139MP0002210_abnormal_sex_determination0.44513011
140MP0005197_abnormal_uvea_morphology0.44495597
141MP0002116_abnormal_craniofacial_bone0.42545441
142MP0002972_abnormal_cardiac_muscle0.42347934
143MP0004085_abnormal_heartbeat0.41495081
144MP0008004_abnormal_stomach_pH0.40799715
145MP0000653_abnormal_sex_gland0.40090244
146MP0005334_abnormal_fat_pad0.38818030
147MP0009697_abnormal_copulation0.37612034
148MP0000432_abnormal_head_morphology0.36629840
149MP0001664_abnormal_digestion0.35754822

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the proximal phalanges of the hand (HP:0009834)7.31469027
2Abnormality of the 1st metacarpal (HP:0010009)7.24860201
3Abnormality of the phalanges of the hallux (HP:0010057)7.00243693
4Cupped ribs (HP:0000887)6.10071197
5Short tibia (HP:0005736)5.70632133
6Abnormality of the 2nd finger (HP:0004100)5.57622597
7Flared iliac wings (HP:0002869)5.48728784
8Premature rupture of membranes (HP:0001788)5.47571083
9Abnormality of the middle phalanges of the toes (HP:0010183)5.47373923
10Short phalanx of the thumb (HP:0009660)5.32741196
11Abnormality of the distal phalanx of the thumb (HP:0009617)5.25361320
12Protrusio acetabuli (HP:0003179)5.21242472
13Relative macrocephaly (HP:0004482)5.18078966
14Gonadotropin excess (HP:0000837)5.16745484
15Aplasia/Hypoplasia of the tibia (HP:0005772)5.11453154
16Abnormality of carpal bone ossification (HP:0006257)5.01897389
17Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)4.98665012
18Absent phalangeal crease (HP:0006109)4.85037235
19Ankle contracture (HP:0006466)4.81006962
20Coxa vara (HP:0002812)4.40850740
21Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)4.34841957
22Cerebral aneurysm (HP:0004944)4.23674442
23Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)4.18949410
24Shallow orbits (HP:0000586)4.11958551
25Abnormal finger flexion creases (HP:0006143)4.09469025
26Menstrual irregularities (HP:0000858)4.07038415
27Abnormal ossification of hand bones (HP:0005921)4.04183031
28Short humerus (HP:0005792)4.03782038
29Short femoral neck (HP:0100864)4.03513215
30Atrophic scars (HP:0001075)4.01562330
31Sex reversal (HP:0012245)3.98842367
32Abnormal sex determination (HP:0012244)3.98842367
33Aortic dissection (HP:0002647)3.91611618
34Hypoplasia of the uterus (HP:0000013)3.89649775
35Abnormal hand bone ossification (HP:0010660)3.87868344
36Gonadal dysgenesis (HP:0000133)3.85137587
37Broad palm (HP:0001169)3.80252910
38Aplasia/hypoplasia of the humerus (HP:0006507)3.76530278
39Aortic aneurysm (HP:0004942)3.73005423
40Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)3.70763452
41Symphalangism affecting the phalanges of the hand (HP:0009773)3.70486303
42Abnormality involving the epiphyses of the lower limbs (HP:0006500)3.52654137
43Abnormality of femoral epiphyses (HP:0006499)3.52654137
44Ovoid vertebral bodies (HP:0003300)3.52014817
45Follicular hyperkeratosis (HP:0007502)3.32246608
46Bladder diverticulum (HP:0000015)3.28654765
47Male infertility (HP:0003251)3.26112065
48Hypoplastic iliac wings (HP:0002866)3.25934541
49Fragile skin (HP:0001030)3.22347848
50Broad metatarsal (HP:0001783)3.19418221
51Premature ovarian failure (HP:0008209)3.18018548
52Lumbar hyperlordosis (HP:0002938)3.11786583
53Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)3.00450004
54Type 1 muscle fiber predominance (HP:0003803)2.97785706
55Arterial tortuosity (HP:0005116)2.96749973
56Vascular tortuosity (HP:0004948)2.95875503
57Aplasia/hypoplasia of the femur (HP:0005613)2.90416593
58Abnormality of the epiphysis of the femoral head (HP:0010574)2.89581594
59Right ventricular cardiomyopathy (HP:0011663)2.86414049
60Testicular neoplasm (HP:0010788)2.86307239
61Short middle phalanx of finger (HP:0005819)2.82602708
62Genu varum (HP:0002970)2.82512158
63Osteomalacia (HP:0002749)2.80613596
64Soft skin (HP:0000977)2.78475982
65Abnormality of male internal genitalia (HP:0000022)2.77777411
66Aplasia/hypoplasia of the uterus (HP:0008684)2.74534575
67Increased connective tissue (HP:0009025)2.73184064
68Abnormality of the femoral head (HP:0003368)2.67165093
69Spinal rigidity (HP:0003306)2.66436674
70Aneurysm (HP:0002617)2.63004990
71Rectal prolapse (HP:0002035)2.62252638
72Abnormality of the epiphyses of the hand (HP:0005924)2.61758843
73Distal upper limb amyotrophy (HP:0007149)2.57162241
74Upper limb amyotrophy (HP:0009129)2.57162241
75Blue sclerae (HP:0000592)2.56244611
76Hand muscle atrophy (HP:0009130)2.55635475
77Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.55528372
78Hypoplasia of the ulna (HP:0003022)2.55473974
79Wrist flexion contracture (HP:0001239)2.50984872
80Mitral valve prolapse (HP:0001634)2.48073896
81Increased variability in muscle fiber diameter (HP:0003557)2.47793811
82Enlarged penis (HP:0000040)2.46635317
83Abnormality involving the epiphyses of the upper limbs (HP:0003839)2.44741334
84Dilatation of the ascending aorta (HP:0005111)2.44387726
85Milia (HP:0001056)2.43394595
86Selective tooth agenesis (HP:0001592)2.42025646
87Alopecia of scalp (HP:0002293)2.37269056
88Wormian bones (HP:0002645)2.35799833
89Nausea (HP:0002018)2.35376533
90Secondary amenorrhea (HP:0000869)2.31589139
91Abnormality of the fibula (HP:0002991)2.31295803
92Bronchomalacia (HP:0002780)2.30765476
93Spinal cord compression (HP:0002176)2.30610292
94Abnormality of dentin (HP:0010299)2.27917675
95Germ cell neoplasia (HP:0100728)2.27496670
96Lymphangioma (HP:0100764)2.25338706
97Hypoplasia of the radius (HP:0002984)2.24995297
98Spondylolisthesis (HP:0003302)2.24671232
99Aplasia/Hypoplasia involving the pelvis (HP:0009103)2.22626466
100Mildly elevated creatine phosphokinase (HP:0008180)2.20502274
101Infertility (HP:0000789)2.19358761
102Fragile nails (HP:0001808)2.18506866
103Neonatal short-limb short stature (HP:0008921)2.17887008
104Abnormality of skeletal muscle fiber size (HP:0012084)2.17215101
105Aplasia/Hypoplasia of the ulna (HP:0006495)2.17102424
106Hypoplastic ilia (HP:0000946)2.16420845
107Aplasia/Hypoplasia of the middle phalanges of the hand (HP:0009843)2.14633007
108Mesangial abnormality (HP:0001966)2.12393931
109Osteolytic defects of the hand bones (HP:0009699)2.11978683
110Osteolytic defects of the phalanges of the hand (HP:0009771)2.11978683
111Overgrowth (HP:0001548)2.08770092
112Coronal craniosynostosis (HP:0004440)2.08180561
113Hypoplastic left heart (HP:0004383)2.08096959
114Genu recurvatum (HP:0002816)2.05919185
115Radial bowing (HP:0002986)2.05572973
116Joint laxity (HP:0001388)2.03598975
117Slender build (HP:0001533)2.02487649
118Peritonitis (HP:0002586)2.01913667
119Short hallux (HP:0010109)2.01048907
120Cervical subluxation (HP:0003308)2.00553390
121Buphthalmos (HP:0000557)1.99734738
122Hyporeflexia of lower limbs (HP:0002600)1.98329257
123Facial diplegia (HP:0001349)1.97803775
124Short thorax (HP:0010306)1.97549484
125Vertebral clefting (HP:0008428)1.97311029
126Tarsal synostosis (HP:0008368)1.93172305
127Abnormal delivery (HP:0001787)1.93108921
128Hyperpituitarism (HP:0010514)1.92632203
129Inguinal hernia (HP:0000023)1.92343524
130Primary amenorrhea (HP:0000786)1.89582278
131Absent toe (HP:0010760)1.87485341
132Bowel diverticulosis (HP:0005222)1.86907453
133Hyperextensible skin (HP:0000974)1.86781915
134Elbow flexion contracture (HP:0002987)1.86443845
135Abnormality of the middle phalanges of the hand (HP:0009833)1.85960111
136Aplasia/Hypoplasia of the hallux (HP:0008362)1.85897612
137Short thumb (HP:0009778)1.84181195
138Wide anterior fontanel (HP:0000260)1.83983630
139Macroorchidism (HP:0000053)1.83680055
140Arachnodactyly (HP:0001166)1.83266357
141Back pain (HP:0003418)1.81655665
142Hypoventilation (HP:0002791)1.81159676
143Thin bony cortex (HP:0002753)1.80607602
144Aplasia involving bones of the upper limbs (HP:0009823)1.80234031
145Aplasia of the phalanges of the hand (HP:0009802)1.80234031
146Aplasia involving bones of the extremities (HP:0009825)1.80234031
147Abnormality of the 4th metacarpal (HP:0010012)1.79741540
148Deviation of the hallux (HP:0010051)1.77007647
149Abnormality of the calcaneus (HP:0008364)1.76886403
150High pitched voice (HP:0001620)1.76252288
151Neonatal death (HP:0003811)1.73986388
152Abnormality of the humerus (HP:0003063)1.73745408
153Synostosis involving bones of the hand (HP:0004278)1.73712901
154Tibial bowing (HP:0002982)1.73058733
155Trismus (HP:0000211)1.72489021
156Hypoplasia of the iris (HP:0007676)1.71704799
157Male pseudohermaphroditism (HP:0000037)1.71134965
158Neoplasm of the heart (HP:0100544)1.71051464
159Abnormality of the wing of the ilium (HP:0011867)1.70856630
160Pterygium (HP:0001059)1.70335607
161Vertebral compression fractures (HP:0002953)1.69886792
162Striae distensae (HP:0001065)1.69306490
163Subacute progressive viral hepatitis (HP:0006572)1.69245470
164Abnormality of the upper arm (HP:0001454)1.69122905
165Ulnar bowing (HP:0003031)1.68670219
166Abnormal vertebral ossification (HP:0100569)1.68649440
167Round ear (HP:0100830)1.67883838
168Synostosis involving bones of the feet (HP:0009140)1.67532314
169Synostosis involving bones of the lower limbs (HP:0009138)1.67532314
170Venous abnormality (HP:0002624)1.66859191
171Hallux valgus (HP:0001822)1.66652400
172Limb-girdle muscle weakness (HP:0003325)1.65621476
173Short 4th metacarpal (HP:0010044)1.65368991
174Forearm undergrowth (HP:0009821)1.52845951
175Hypoplastic heart (HP:0001961)1.52166458
176Complete atrioventricular canal defect (HP:0001674)1.51196266
177Transposition of the great arteries (HP:0001669)1.50389531
178Abnormal connection of the cardiac segments (HP:0011545)1.50389531
179Abnormal ventriculo-arterial connection (HP:0011563)1.50389531
180Deviation of the thumb (HP:0009603)1.48294917
181Short ribs (HP:0000773)1.48068902

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PRPF4B7.81905882
2TAOK25.22914186
3TRIB34.16634730
4EPHA23.77413176
5RIPK13.26791193
6LATS13.10803430
7PKN22.73749710
8FER2.72865952
9PDGFRA2.70197259
10ERN12.52533268
11LATS22.44731701
12EPHB22.33420395
13PTK62.30210479
14TYRO32.27961046
15SIK12.23162915
16TTN2.20441303
17CDK122.13646988
18EPHB11.96284606
19EEF2K1.88015603
20DDR21.87232381
21PAK41.75890530
22PTK21.71915969
23ICK1.68832802
24SMG11.68724820
25TGFBR21.46731431
26CAMK1D1.44715310
27PAK21.44188167
28BMX1.43747017
29MET1.43564225
30EPHA31.41922604
31MAPK151.34509938
32FGFR11.30331719
33CAMK1G1.26623077
34RPS6KL11.23910297
35RPS6KC11.23910297
36FGFR41.21609871
37PTK2B1.20657245
38CDK81.19724531
39MTOR1.17265737
40STK31.15521841
41MAPKAPK31.14928075
42CDK61.12017957
43RET1.10307761
44LRRK21.10104778
45LMTK21.08550576
46PRKD31.08324829
47RPS6KA61.06188420
48PAK31.05582556
49PIK3CG1.02029897
50RPS6KA51.01986794
51MELK1.01942169
52PDGFRB0.98655817
53MYLK0.96260777
54RPS6KB20.92536918
55DMPK0.92483245
56CDK30.90499738
57MAP2K10.85438009
58FGFR20.85322440
59CDK70.84827953
60MAP3K100.84721710
61TESK10.84364087
62FGFR30.83619286
63PRKAA20.79249870
64STK38L0.77252959
65MST1R0.76499663
66MAP3K20.75461457
67CDK90.74201872
68MATK0.73322049
69TGFBR10.71702741
70KDR0.71359432
71MAP3K70.70042411
72CDC42BPA0.67964905
73NTRK10.66155688
74ERBB20.65941219
75RPS6KA10.65786781
76PDK20.65122783
77DAPK20.64958818
78GSK3A0.64736925
79BRD40.64541253
80SCYL20.63333806
81ROCK10.62093107
82PAK10.60574526
83MUSK0.60210206
84TAF10.59852040
85TRPM70.58477736
86NEK60.53207256
87PRKD20.49586349
88ARAF0.48974585
89MAP3K30.47448781
90PRKD10.46962577
91MAP2K20.46945726
92KSR20.46267868
93ROCK20.45878497
94STK380.45699881
95CSNK1A1L0.45410498
96CDK40.45113135
97ILK0.44334423
98IRAK30.42866974
99EIF2AK10.42422768
100FLT30.41233711
101DYRK1B0.41017600
102STK40.40968070
103LIMK10.40735097
104SRC0.40279328
105MAPK10.39410032
106RPS6KA20.39300356
107INSR0.38781626
108RPS6KA40.37938752
109TIE10.36721484
110ALK0.36181383
111PNCK0.35132721
112DAPK30.33898724
113EGFR0.33838089
114HIPK20.32226509
115NME10.31908402
116PRKAA10.30848810
117TNK20.29942854
118MAPK30.29924519
119CSNK1G10.29430901
120PDPK10.28222869
121IGF1R0.28090676
122NEK90.26788069
123TSSK60.26567228
124CHUK0.25540952
125PAK60.25023029
126ERBB40.24628228
127CSNK1D0.24119917
128MAPK90.24032282
129MAP3K90.23812756
130CAMK2G0.23630788
131CSF1R0.22835849
132MAPK70.22802739
133PRKCI0.21851571
134PDK40.21642513
135PDK30.21642513
136WNK10.21285065
137MOS0.19588026
138CAMK2B0.17898925
139MAPKAPK20.17885992
140NLK0.16776468
141PRKCE0.16375197
142RPS6KA30.15306960

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005334.93339420
2ECM-receptor interaction_Homo sapiens_hsa045123.76105634
3Ovarian steroidogenesis_Homo sapiens_hsa049132.83748329
4Focal adhesion_Homo sapiens_hsa045102.56412801
5Amoebiasis_Homo sapiens_hsa051462.11588260
6Fatty acid biosynthesis_Homo sapiens_hsa000612.10615346
7Adherens junction_Homo sapiens_hsa045202.08198937
8Small cell lung cancer_Homo sapiens_hsa052222.06887335
9Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.02003852
10Proteoglycans in cancer_Homo sapiens_hsa052052.01361110
11Hippo signaling pathway_Homo sapiens_hsa043901.99798712
12* TGF-beta signaling pathway_Homo sapiens_hsa043501.97598631
13Basal cell carcinoma_Homo sapiens_hsa052171.82583791
14Steroid hormone biosynthesis_Homo sapiens_hsa001401.70474813
15AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.68927305
16Protein digestion and absorption_Homo sapiens_hsa049741.65281459
17Phenylalanine metabolism_Homo sapiens_hsa003601.63144092
18Hedgehog signaling pathway_Homo sapiens_hsa043401.63061310
19Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.57679944
20Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.55224173
21PPAR signaling pathway_Homo sapiens_hsa033201.53211584
22Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.49756531
23Bladder cancer_Homo sapiens_hsa052191.36039831
24Dilated cardiomyopathy_Homo sapiens_hsa054141.33967418
25Tight junction_Homo sapiens_hsa045301.33284897
26Prion diseases_Homo sapiens_hsa050201.32003820
27Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.31720652
28* Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.30285766
29Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.30194137
30Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.30067199
31Chemical carcinogenesis_Homo sapiens_hsa052041.27914633
32MicroRNAs in cancer_Homo sapiens_hsa052061.25491183
33PI3K-Akt signaling pathway_Homo sapiens_hsa041511.24987737
34Central carbon metabolism in cancer_Homo sapiens_hsa052301.24166579
35Pentose phosphate pathway_Homo sapiens_hsa000301.22011744
36Axon guidance_Homo sapiens_hsa043601.21356573
37Fructose and mannose metabolism_Homo sapiens_hsa000511.21043951
38Dorso-ventral axis formation_Homo sapiens_hsa043201.20943684
39Steroid biosynthesis_Homo sapiens_hsa001001.19923397
40Complement and coagulation cascades_Homo sapiens_hsa046101.19550318
41Chronic myeloid leukemia_Homo sapiens_hsa052201.18357537
42Fatty acid metabolism_Homo sapiens_hsa012121.14134974
43Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.13593441
44Glutathione metabolism_Homo sapiens_hsa004801.13301792
45Notch signaling pathway_Homo sapiens_hsa043301.13108703
46Histidine metabolism_Homo sapiens_hsa003401.09311904
47Pathways in cancer_Homo sapiens_hsa052001.08913532
48Pancreatic cancer_Homo sapiens_hsa052121.06742515
49Adipocytokine signaling pathway_Homo sapiens_hsa049201.06186970
50Toxoplasmosis_Homo sapiens_hsa051450.99076682
51Aldosterone synthesis and secretion_Homo sapiens_hsa049250.99051304
52Regulation of actin cytoskeleton_Homo sapiens_hsa048100.97268179
53Estrogen signaling pathway_Homo sapiens_hsa049150.97057384
54Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.96335397
55Thyroid hormone signaling pathway_Homo sapiens_hsa049190.95938726
56Insulin resistance_Homo sapiens_hsa049310.95815560
57Renal cell carcinoma_Homo sapiens_hsa052110.95252700
58Nitrogen metabolism_Homo sapiens_hsa009100.94305296
59Galactose metabolism_Homo sapiens_hsa000520.93983571
60Viral myocarditis_Homo sapiens_hsa054160.93602041
61Prostate cancer_Homo sapiens_hsa052150.93047423
62Leukocyte transendothelial migration_Homo sapiens_hsa046700.92417889
63Wnt signaling pathway_Homo sapiens_hsa043100.91844362
64Endometrial cancer_Homo sapiens_hsa052130.89917331
65Lysine degradation_Homo sapiens_hsa003100.89066954
66Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.87891572
67Rap1 signaling pathway_Homo sapiens_hsa040150.87862275
68Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.87810684
69Melanogenesis_Homo sapiens_hsa049160.86626522
70AMPK signaling pathway_Homo sapiens_hsa041520.85446392
71Tyrosine metabolism_Homo sapiens_hsa003500.85297651
72Renin secretion_Homo sapiens_hsa049240.83751559
73mTOR signaling pathway_Homo sapiens_hsa041500.82423091
74Fatty acid elongation_Homo sapiens_hsa000620.81421462
75Thyroid hormone synthesis_Homo sapiens_hsa049180.80905018
76Longevity regulating pathway - mammal_Homo sapiens_hsa042110.80608235
77Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.80395760
78Vascular smooth muscle contraction_Homo sapiens_hsa042700.80235951
79Colorectal cancer_Homo sapiens_hsa052100.78817907
80Prolactin signaling pathway_Homo sapiens_hsa049170.77108143
81Glioma_Homo sapiens_hsa052140.74711183
82Glycosaminoglycan degradation_Homo sapiens_hsa005310.74578777
83Arginine biosynthesis_Homo sapiens_hsa002200.73346582
84Melanoma_Homo sapiens_hsa052180.73271504
85HIF-1 signaling pathway_Homo sapiens_hsa040660.72506961
86Malaria_Homo sapiens_hsa051440.72133933
87VEGF signaling pathway_Homo sapiens_hsa043700.71760315
88Arginine and proline metabolism_Homo sapiens_hsa003300.71293562
89Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.70782133
90Choline metabolism in cancer_Homo sapiens_hsa052310.69388716
91HTLV-I infection_Homo sapiens_hsa051660.69299858
92Pentose and glucuronate interconversions_Homo sapiens_hsa000400.69146731
93Cocaine addiction_Homo sapiens_hsa050300.68463084
94Thyroid cancer_Homo sapiens_hsa052160.68286802
95cGMP-PKG signaling pathway_Homo sapiens_hsa040220.67322848
96Lysosome_Homo sapiens_hsa041420.66738122
97Hepatitis B_Homo sapiens_hsa051610.65401805
98Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.65114983
99ABC transporters_Homo sapiens_hsa020100.63239019
100Mineral absorption_Homo sapiens_hsa049780.62525132
101Insulin signaling pathway_Homo sapiens_hsa049100.62510791
102beta-Alanine metabolism_Homo sapiens_hsa004100.61323023
103Fatty acid degradation_Homo sapiens_hsa000710.60178284
104Ras signaling pathway_Homo sapiens_hsa040140.59839525
105Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.59313836
106FoxO signaling pathway_Homo sapiens_hsa040680.58422183
107Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.57592453
108Bile secretion_Homo sapiens_hsa049760.57457546
109Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.57166278
110cAMP signaling pathway_Homo sapiens_hsa040240.55683461
111Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.55353966
112GnRH signaling pathway_Homo sapiens_hsa049120.55036861
113Phospholipase D signaling pathway_Homo sapiens_hsa040720.53388928
114Gap junction_Homo sapiens_hsa045400.52229812
115Glucagon signaling pathway_Homo sapiens_hsa049220.51955650
116Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.51211361
117Antigen processing and presentation_Homo sapiens_hsa046120.50738816
118Starch and sucrose metabolism_Homo sapiens_hsa005000.50336799
119Platelet activation_Homo sapiens_hsa046110.50144852
120Pyruvate metabolism_Homo sapiens_hsa006200.49485970
121Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.47245063
122Phagosome_Homo sapiens_hsa041450.43926926
123Vitamin digestion and absorption_Homo sapiens_hsa049770.43594887
124Glycerolipid metabolism_Homo sapiens_hsa005610.43327098
125Oxytocin signaling pathway_Homo sapiens_hsa049210.43202024
126ErbB signaling pathway_Homo sapiens_hsa040120.42977659
127TNF signaling pathway_Homo sapiens_hsa046680.41965995
128Endocytosis_Homo sapiens_hsa041440.41894421
129Salmonella infection_Homo sapiens_hsa051320.41738362
130N-Glycan biosynthesis_Homo sapiens_hsa005100.41325730
131Fat digestion and absorption_Homo sapiens_hsa049750.40869238
132Drug metabolism - other enzymes_Homo sapiens_hsa009830.40841546
133Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.36810529
134Hepatitis C_Homo sapiens_hsa051600.36571667
135Retinol metabolism_Homo sapiens_hsa008300.32411731
136Sulfur relay system_Homo sapiens_hsa041220.31194072
137Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.28271515

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