INHBE

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the TGF-beta (transforming growth factor-beta) superfamily of proteins. The encoded preproprotein is proteolytically processed to generate an inhibin beta subunit. Inhibins have been implicated in regulating numerous cellular processes including cell proliferation, apoptosis, immune response and hormone secretion. This gene may be upregulated under conditions of endoplasmic reticulum stress, and this protein may inhibit cellular proliferation and growth in pancreas and liver. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.48524390
2L-phenylalanine catabolic process (GO:0006559)7.48524390
3L-phenylalanine metabolic process (GO:0006558)7.16078599
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)7.16078599
5exogenous drug catabolic process (GO:0042738)6.88659703
6aromatic amino acid family catabolic process (GO:0009074)6.74883551
7triglyceride-rich lipoprotein particle remodeling (GO:0034370)6.58937826
8tryptophan catabolic process (GO:0006569)6.10201817
9indole-containing compound catabolic process (GO:0042436)6.10201817
10indolalkylamine catabolic process (GO:0046218)6.10201817
11epoxygenase P450 pathway (GO:0019373)6.07647397
12kynurenine metabolic process (GO:0070189)6.04284639
13bile acid biosynthetic process (GO:0006699)6.01053244
14omega-hydroxylase P450 pathway (GO:0097267)5.92897862
15alpha-linolenic acid metabolic process (GO:0036109)5.89380012
16glyoxylate metabolic process (GO:0046487)5.78124400
17tryptophan metabolic process (GO:0006568)5.75010091
18high-density lipoprotein particle remodeling (GO:0034375)5.63248820
19negative regulation of fibrinolysis (GO:0051918)5.59508069
20urea metabolic process (GO:0019627)5.57998231
21urea cycle (GO:0000050)5.57998231
22regulation of fibrinolysis (GO:0051917)5.42754902
23peptidyl-glutamic acid carboxylation (GO:0017187)5.38779069
24protein carboxylation (GO:0018214)5.38779069
25regulation of protein activation cascade (GO:2000257)5.33587619
26regulation of plasminogen activation (GO:0010755)5.29473550
27complement activation, alternative pathway (GO:0006957)5.29282391
28sulfur amino acid catabolic process (GO:0000098)5.19657112
29cysteine metabolic process (GO:0006534)5.18201968
30bile acid metabolic process (GO:0008206)5.14400467
31nitrogen cycle metabolic process (GO:0071941)5.13059550
32serine family amino acid catabolic process (GO:0009071)5.08063411
33oxidative demethylation (GO:0070989)5.05729258
34fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)5.01265030
35regulation of triglyceride catabolic process (GO:0010896)4.98554524
36regulation of complement activation (GO:0030449)4.95772096
37reverse cholesterol transport (GO:0043691)4.95416550
38regulation of cholesterol esterification (GO:0010872)4.94382360
39aromatic amino acid family metabolic process (GO:0009072)4.90638095
40plasma lipoprotein particle remodeling (GO:0034369)4.84642167
41protein-lipid complex remodeling (GO:0034368)4.84642167
42macromolecular complex remodeling (GO:0034367)4.84642167
43drug metabolic process (GO:0017144)4.83037238
44tyrosine metabolic process (GO:0006570)4.73568541
45acylglycerol homeostasis (GO:0055090)4.70872946
46triglyceride homeostasis (GO:0070328)4.70872946
47phospholipid efflux (GO:0033700)4.70316245
48amino-acid betaine metabolic process (GO:0006577)4.67025218
49cellular ketone body metabolic process (GO:0046950)4.66818929
50negative regulation of cholesterol transport (GO:0032375)4.66755176
51negative regulation of sterol transport (GO:0032372)4.66755176
52negative regulation of hemostasis (GO:1900047)4.63561253
53negative regulation of blood coagulation (GO:0030195)4.63561253
54alpha-amino acid catabolic process (GO:1901606)4.61173423
55homocysteine metabolic process (GO:0050667)4.58050960
56lysine metabolic process (GO:0006553)4.57663578
57lysine catabolic process (GO:0006554)4.57663578
58L-serine metabolic process (GO:0006563)4.52978381
59coenzyme catabolic process (GO:0009109)4.45323727
60intestinal cholesterol absorption (GO:0030299)4.43414959
61glycine metabolic process (GO:0006544)4.42851489
62bile acid and bile salt transport (GO:0015721)4.41493740
63plasma lipoprotein particle clearance (GO:0034381)4.40883047
64indolalkylamine metabolic process (GO:0006586)4.32519546
65phenylpropanoid metabolic process (GO:0009698)4.31879285
66imidazole-containing compound metabolic process (GO:0052803)4.29251012
67cholesterol efflux (GO:0033344)4.28253880
68cellular glucuronidation (GO:0052695)4.28225790
69regulation of lipoprotein particle clearance (GO:0010984)4.27932789
70cellular amino acid catabolic process (GO:0009063)4.23600250
71glutamate metabolic process (GO:0006536)4.22560144
72cellular biogenic amine catabolic process (GO:0042402)4.22139019
73amine catabolic process (GO:0009310)4.22139019
74negative regulation of coagulation (GO:0050819)4.21625512
75negative regulation of wound healing (GO:0061045)4.16516685
76regulation of humoral immune response (GO:0002920)4.16287135
77serine family amino acid metabolic process (GO:0009069)4.14308792
78acute-phase response (GO:0006953)4.09479231
79ethanol oxidation (GO:0006069)4.08485826
80benzene-containing compound metabolic process (GO:0042537)4.05940142
81dicarboxylic acid biosynthetic process (GO:0043650)4.04515706
82ketone body metabolic process (GO:1902224)4.04284666
83low-density lipoprotein particle remodeling (GO:0034374)4.01761617
84fibrinolysis (GO:0042730)4.01170502
85plasma lipoprotein particle assembly (GO:0034377)4.00360624
86cellular modified amino acid catabolic process (GO:0042219)4.00003414
87arginine metabolic process (GO:0006525)3.98256490
88positive regulation of lipoprotein lipase activity (GO:0051006)3.97625792
89positive regulation of triglyceride lipase activity (GO:0061365)3.97625792
90negative regulation of protein activation cascade (GO:2000258)3.97261315
91aldehyde catabolic process (GO:0046185)3.97096243
92serine family amino acid biosynthetic process (GO:0009070)3.94253299
93drug catabolic process (GO:0042737)3.88976171
94positive regulation of lipid catabolic process (GO:0050996)3.87685954
95blood coagulation, intrinsic pathway (GO:0007597)3.87003965
96regulation of apoptotic cell clearance (GO:2000425)3.83196707
97cofactor catabolic process (GO:0051187)3.79628993
98glucuronate metabolic process (GO:0019585)3.79594227
99uronic acid metabolic process (GO:0006063)3.79594227
100negative regulation of lipase activity (GO:0060192)3.78922608
101complement activation, classical pathway (GO:0006958)3.78364990
102S-adenosylmethionine metabolic process (GO:0046500)3.78030413
103cholesterol homeostasis (GO:0042632)3.76032383
104positive regulation of hemostasis (GO:1900048)3.75790376
105positive regulation of blood coagulation (GO:0030194)3.75790376
106phospholipid homeostasis (GO:0055091)3.75279623
107regulation of bile acid biosynthetic process (GO:0070857)3.74900609
108organic acid catabolic process (GO:0016054)3.73850877
109carboxylic acid catabolic process (GO:0046395)3.73850877
110very-low-density lipoprotein particle assembly (GO:0034379)3.73746462
111heme transport (GO:0015886)3.73137200
112protein activation cascade (GO:0072376)3.72811649
113complement activation (GO:0006956)3.72783967
114regulation of cholesterol homeostasis (GO:2000188)3.72128643
115proline metabolic process (GO:0006560)3.72046566
116cytolysis (GO:0019835)3.70843392
117sterol homeostasis (GO:0055092)3.69756470
118alkaloid metabolic process (GO:0009820)3.69609095
119plasma lipoprotein particle organization (GO:0071827)3.67150079
120short-chain fatty acid metabolic process (GO:0046459)3.66050593
121acetyl-CoA metabolic process (GO:0006084)3.63981433
122flavonoid metabolic process (GO:0009812)3.61429089
123protein-lipid complex assembly (GO:0065005)3.58849642
124ethanol metabolic process (GO:0006067)3.58676619
125positive regulation of fatty acid beta-oxidation (GO:0032000)3.58435558
126opsonization (GO:0008228)3.53929217
127negative regulation of fatty acid biosynthetic process (GO:0045717)3.52589926
128peptidyl-glutamic acid modification (GO:0018200)3.42431924
129positive regulation of coagulation (GO:0050820)3.40155638
130positive regulation of heterotypic cell-cell adhesion (GO:0034116)3.34645002
131protein-lipid complex subunit organization (GO:0071825)3.33284900

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* RXR_22158963_ChIP-Seq_LIVER_Mouse8.43091790
2* PPARA_22158963_ChIP-Seq_LIVER_Mouse7.23209283
3EGR1_23403033_ChIP-Seq_LIVER_Mouse7.02832342
4* LXR_22158963_ChIP-Seq_LIVER_Mouse6.50661585
5FOXO1_23066095_ChIP-Seq_LIVER_Mouse5.31330846
6CEBPA_23403033_ChIP-Seq_LIVER_Mouse5.07567831
7PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.92670460
8NR1I2_20693526_ChIP-Seq_LIVER_Mouse4.05822654
9CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.98463775
10E2F7_22180533_ChIP-Seq_HELA_Human2.21417223
11TCF7L2_21901280_ChIP-Seq_H4IIE_Rat2.05523421
12TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.01106978
13ESR1_17901129_ChIP-ChIP_LIVER_Mouse11.9956659
14* HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.91337885
15IRF1_19129219_ChIP-ChIP_H3396_Human1.68856456
16FOXA2_19822575_ChIP-Seq_HepG2_Human1.60691725
17HTT_18923047_ChIP-ChIP_STHdh_Human1.55404360
18CLOCK_20551151_ChIP-Seq_293T_Human1.52313942
19KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.49347302
20GATA1_22025678_ChIP-Seq_K562_Human1.47180204
21* HNF4A_19822575_ChIP-Seq_HepG2_Human1.39721504
22THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.31277985
23GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.21242914
24RXRA_24833708_ChIP-Seq_LIVER_Mouse1.19985128
25STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.18721261
26STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.18219978
27ZNF274_21170338_ChIP-Seq_K562_Hela1.16015556
28MYC_18555785_ChIP-Seq_MESCs_Mouse1.10885183
29ESR1_15608294_ChIP-ChIP_MCF-7_Human1.02407917
30ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.01822003
31NFE2_27457419_Chip-Seq_LIVER_Mouse1.01329879
32PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.01083882
33IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.99448161
34IGF1R_20145208_ChIP-Seq_DFB_Human0.94283664
35GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.94087620
36JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.92835684
37HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.92204227
38RAC3_21632823_ChIP-Seq_H3396_Human0.91540398
39SOX2_27498859_Chip-Seq_STOMACH_Mouse0.89992808
40ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.89932715
41PHF8_20622853_ChIP-Seq_HELA_Human0.89558223
42EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.88867503
43SRF_21415370_ChIP-Seq_HL-1_Mouse0.88512080
44HNFA_21074721_ChIP-Seq_CACO-2_Human0.88277333
45CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.85889089
46TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.85311959
47PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.85052643
48CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.84835404
49AUTS2_25519132_ChIP-Seq_293T-REX_Human0.84308451
50EST1_17652178_ChIP-ChIP_JURKAT_Human0.83892683
51ETV2_25802403_ChIP-Seq_MESCs_Mouse0.82521362
52GABP_17652178_ChIP-ChIP_JURKAT_Human0.82149048
53OCT4_20526341_ChIP-Seq_ESCs_Human0.81329587
54ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.80890243
55CBX2_22325352_ChIP-Seq_293T-Rex_Human0.80196484
56CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.80181701
57RARG_19884340_ChIP-ChIP_MEFs_Mouse0.79638212
58PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.79509022
59GATA6_21074721_ChIP-Seq_CACO-2_Human0.79256348
60MYC_18358816_ChIP-ChIP_MESCs_Mouse0.78121493
61POU5F1_16518401_ChIP-PET_MESCs_Mouse0.77778157
62BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.77203874
63GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.77181010
64GATA4_25053715_ChIP-Seq_YYC3_Human0.77149620
65MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.75952392
66IRF8_22096565_ChIP-ChIP_GC-B_Human0.75641909
67SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.75597075
68SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.75051566
69KAP1_22055183_ChIP-Seq_ESCs_Mouse0.74869271
70RBPJ_21746931_ChIP-Seq_IB4_Human0.74423482
71ERA_21632823_ChIP-Seq_H3396_Human0.74362149
72EZH2_27294783_Chip-Seq_NPCs_Mouse0.73949063
73CTCF_20526341_ChIP-Seq_ESCs_Human0.73474486
74FOXA1_25329375_ChIP-Seq_VCAP_Human0.73128598
75FOXA1_27270436_Chip-Seq_PROSTATE_Human0.73128598
76NFYA_21822215_ChIP-Seq_K562_Human0.72989356
77ETV1_20927104_ChIP-Seq_GIST48_Human0.72838411
78MYC_19829295_ChIP-Seq_ESCs_Human0.72667191
79SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.72028004
80KLF5_20875108_ChIP-Seq_MESCs_Mouse0.71945254
81RARA_24833708_ChIP-Seq_LIVER_Mouse0.71531246
82Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.70694920
83* GATA3_21878914_ChIP-Seq_MCF-7_Human0.70114187
84CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.69689357
85SA1_27219007_Chip-Seq_Bcells_Human0.69290710
86MYC_18940864_ChIP-ChIP_HL60_Human0.68686954
87AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.68532486
88NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.66363609
89ESR2_21235772_ChIP-Seq_MCF-7_Human0.66351926
90E2F1_20622854_ChIP-Seq_HELA_Human0.66237697
91SUZ12_27294783_Chip-Seq_NPCs_Mouse0.65922370
92NANOG_20526341_ChIP-Seq_ESCs_Human0.65806249
93SALL4_18804426_ChIP-ChIP_XEN_Mouse0.65525021
94ETS1_20019798_ChIP-Seq_JURKAT_Human0.65145533
95ER_23166858_ChIP-Seq_MCF-7_Human0.64787683
96NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.63766932
97NRF2_20460467_ChIP-Seq_MEFs_Mouse0.63766932
98POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.63749630
99PIAS1_25552417_ChIP-Seq_VCAP_Human0.63160849
100PCGF2_27294783_Chip-Seq_NPCs_Mouse0.62683616
101NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.62517102
102ERG_20517297_ChIP-Seq_VCAP_Human0.62165436
103CREB1_15753290_ChIP-ChIP_HEK293T_Human0.61940568
104RARB_24833708_ChIP-Seq_LIVER_Mouse0.61918412
105RAD21_21589869_ChIP-Seq_MESCs_Mouse0.61758654
106E2F1_18555785_ChIP-Seq_MESCs_Mouse0.61034891
107BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.60851669
108NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.60622996
109SOX2_21211035_ChIP-Seq_LN229_Human0.60609076
110PCGF4_22325352_ChIP-Seq_293T-Rex_Human0.60064015
111NANOG_19829295_ChIP-Seq_ESCs_Human0.59958733
112SOX2_19829295_ChIP-Seq_ESCs_Human0.59958733
113ZNF263_19887448_ChIP-Seq_K562_Human0.59776295
114FOXH1_21741376_ChIP-Seq_ESCs_Human0.59413492
115NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.58960523
116CEBPB_22108803_ChIP-Seq_LS180_Human0.57596486
117* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.55825380
118LXR_22292898_ChIP-Seq_THP-1_Human0.53107004
119STAT3_1855785_ChIP-Seq_MESCs_Mouse0.52987578
120EGR1_19032775_ChIP-ChIP_M12_Human0.52357692
121PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.52156209
122FOXA1_25552417_ChIP-Seq_VCAP_Human0.51298148
123MYC_19915707_ChIP-ChIP_AK7_Human0.50936225
124AR_20517297_ChIP-Seq_VCAP_Human0.50840093
125FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.50111758
126FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.49594816
127ESET_19884257_ChIP-Seq_ESCs_Mouse0.49267822
128CBP_21632823_ChIP-Seq_H3396_Human0.49235369
129TAF15_26573619_Chip-Seq_HEK293_Human0.48749601
130STAT1_17558387_ChIP-Seq_HELA_Human0.48644871
131E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.47020024
132PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.46961454
133P53_21459846_ChIP-Seq_SAOS-2_Human0.45861779
134PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.45323374
135CDX2_20551321_ChIP-Seq_CACO-2_Human0.45265949
136ESR1_21235772_ChIP-Seq_MCF-7_Human0.44326468
137PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.41978728
138GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.41297016
139BCAT_22108803_ChIP-Seq_LS180_Human0.41161138
140TAF2_19829295_ChIP-Seq_ESCs_Human0.41156937
141CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.40920379
142GATA1_19941827_ChIP-Seq_MEL_Mouse0.40842490
143FOXO3_23340844_ChIP-Seq_DLD1_Human0.40819637
144FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.40666737
145STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.40420456
146GATA1_19941826_ChIP-Seq_K562_Human0.40118852
147* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.39281290
148ESR1_20079471_ChIP-ChIP_T-47D_Human0.39215130
149FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.38918152
150ERG_21242973_ChIP-ChIP_JURKAT_Human0.38856585
151GATA2_19941826_ChIP-Seq_K562_Human0.38406896
152PPAR_26484153_Chip-Seq_NCI-H1993_Human0.38032541
153MYC_27129775_Chip-Seq_CORNEA_Mouse0.37580374
154GATA6_25053715_ChIP-Seq_YYC3_Human0.36763810
155SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.36095228
156SPI1_26923725_Chip-Seq_HPCs_Mouse0.33794472
157FOXH1_21741376_ChIP-Seq_EPCs_Human0.33506227
158NCOR_22424771_ChIP-Seq_293T_Human0.33491612
159* LUZP1_20508642_ChIP-Seq_ESCs_Mouse0.33351463
160CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.33226308
161MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.33203664

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system8.43877677
2MP0005360_urolithiasis7.42912937
3MP0005085_abnormal_gallbladder_physiolo6.48216727
4MP0005365_abnormal_bile_salt6.19943121
5MP0008875_abnormal_xenobiotic_pharmacok5.20116317
6MP0003806_abnormal_nucleotide_metabolis4.26091779
7MP0003252_abnormal_bile_duct3.95448892
8MP0010329_abnormal_lipoprotein_level3.62460152
9MP0009840_abnormal_foam_cell3.36692906
10MP0005083_abnormal_biliary_tract3.14096707
11MP0003195_calcinosis2.76985671
12MP0005332_abnormal_amino_acid2.72240901
13MP0001666_abnormal_nutrient_absorption2.60158423
14MP0003191_abnormal_cellular_cholesterol2.32506901
15MP0000609_abnormal_liver_physiology2.17817417
16MP0002118_abnormal_lipid_homeostasis2.12684348
17MP0004019_abnormal_vitamin_homeostasis2.09392372
18MP0003868_abnormal_feces_composition1.95225997
19MP0002138_abnormal_hepatobiliary_system1.93142720
20MP0005319_abnormal_enzyme/_coenzyme1.82456040
21MP0009697_abnormal_copulation1.61239766
22MP0001764_abnormal_homeostasis1.60255133
23MP0005584_abnormal_enzyme/coenzyme_acti1.55335545
24MP0000566_synostosis1.52858289
25MP0005451_abnormal_body_composition1.52644951
26MP0003011_delayed_dark_adaptation1.40948508
27MP0003656_abnormal_erythrocyte_physiolo1.25255517
28MP0003186_abnormal_redox_activity1.22650072
29MP0005647_abnormal_sex_gland1.19546288
30MP0009643_abnormal_urine_homeostasis1.19063672
31MP0000598_abnormal_liver_morphology1.17020637
32MP0003646_muscle_fatigue1.15638288
33MP0003122_maternal_imprinting1.11501191
34MP0003705_abnormal_hypodermis_morpholog1.11143561
35MP0000604_amyloidosis1.10188533
36MP0009764_decreased_sensitivity_to1.07927418
37MP0002254_reproductive_system_inflammat1.02977721
38MP0009763_increased_sensitivity_to1.01457085
39MP0006292_abnormal_olfactory_placode0.96686579
40MP0010368_abnormal_lymphatic_system0.95484712
41MP0003136_yellow_coat_color0.93072096
42MP0005646_abnormal_pituitary_gland0.91534025
43MP0005636_abnormal_mineral_homeostasis0.89291725
44MP0005645_abnormal_hypothalamus_physiol0.89158690
45MP0005187_abnormal_penis_morphology0.88392336
46MP0008469_abnormal_protein_level0.87722613
47MP0009642_abnormal_blood_homeostasis0.86426974
48MP0006036_abnormal_mitochondrial_physio0.81694977
49MP0005408_hypopigmentation0.80968115
50MP0001915_intracranial_hemorrhage0.80451872
51MP0003890_abnormal_embryonic-extraembry0.79168264
52MP0005670_abnormal_white_adipose0.78801539
53MP0002876_abnormal_thyroid_physiology0.78753221
54MP0002078_abnormal_glucose_homeostasis0.78730268
55MP0005376_homeostasis/metabolism_phenot0.77740875
56MP0009765_abnormal_xenobiotic_induced0.77605452
57MP0005084_abnormal_gallbladder_morpholo0.74121999
58MP0002089_abnormal_postnatal_growth/wei0.73676870
59MP0004130_abnormal_muscle_cell0.73512431
60MP0002971_abnormal_brown_adipose0.71194658
61MP0003567_abnormal_fetal_cardiomyocyte0.70919412
62MP0005334_abnormal_fat_pad0.70431156
63MP0003690_abnormal_glial_cell0.69217659
64MP0005220_abnormal_exocrine_pancreas0.68470761
65MP0005379_endocrine/exocrine_gland_phen0.68032107
66MP0005535_abnormal_body_temperature0.66722624
67MP0005266_abnormal_metabolism0.64861822
68MP0001661_extended_life_span0.64780042
69MP0003329_amyloid_beta_deposits0.64564467
70MP0005551_abnormal_eye_electrophysiolog0.63912212
71MP0009053_abnormal_anal_canal0.63154436
72MP0002282_abnormal_trachea_morphology0.63040813
73MP0003941_abnormal_skin_development0.62302898
74MP0000639_abnormal_adrenal_gland0.59954406
75MP0002249_abnormal_larynx_morphology0.59805073
76MP0006035_abnormal_mitochondrial_morpho0.58827605
77MP0003959_abnormal_lean_body0.56485973
78MP0005448_abnormal_energy_balance0.55883573
79MP0001756_abnormal_urination0.55654287
80MP0004133_heterotaxia0.55164163
81MP0003693_abnormal_embryo_hatching0.53470089
82MP0001293_anophthalmia0.52866276
83MP0005464_abnormal_platelet_physiology0.52400906
84MP0002697_abnormal_eye_size0.52243193
85MP0004233_abnormal_muscle_weight0.51333003
86MP0002822_catalepsy0.49345776
87MP0004142_abnormal_muscle_tone0.48599011
88MP0005395_other_phenotype0.48421215
89MP0008007_abnormal_cellular_replicative0.48371773
90MP0010030_abnormal_orbit_morphology0.48105984
91MP0005377_hearing/vestibular/ear_phenot0.47304849
92MP0003878_abnormal_ear_physiology0.47304849
93MP0008874_decreased_physiological_sensi0.46767140
94MP0005410_abnormal_fertilization0.46758711
95MP0003638_abnormal_response/metabolism_0.46440303
96MP0003718_maternal_effect0.46240255
97MP0004782_abnormal_surfactant_physiolog0.46118837
98MP0002837_dystrophic_cardiac_calcinosis0.44727733
99MP0005248_abnormal_Harderian_gland0.44148244
100MP0002928_abnormal_bile_duct0.43530313
101MP0008873_increased_physiological_sensi0.42756606
102MP0002136_abnormal_kidney_physiology0.42463948
103MP0003953_abnormal_hormone_level0.40903843
104MP0001324_abnormal_eye_pigmentation0.40534742
105MP0003436_decreased_susceptibility_to0.39904374
106MP0003075_altered_response_to0.39689836
107MP0001944_abnormal_pancreas_morphology0.38866023
108MP0003724_increased_susceptibility_to0.38765892
109MP0001529_abnormal_vocalization0.38655145
110MP0005666_abnormal_adipose_tissue0.38379301
111MP0005166_decreased_susceptibility_to0.37524906
112MP0003879_abnormal_hair_cell0.37489378
113MP0004381_abnormal_hair_follicle0.36970992
114MP0008872_abnormal_physiological_respon0.36882017
115MP0000579_abnormal_nail_morphology0.36640479
116MP0003937_abnormal_limbs/digits/tail_de0.35894578
117MP0003943_abnormal_hepatobiliary_system0.35381684
118MP0003119_abnormal_digestive_system0.35334961
119MP0002938_white_spotting0.35222988
120MP0003699_abnormal_female_reproductive0.35156088
121MP0009672_abnormal_birth_weight0.33300229
122MP0009115_abnormal_fat_cell0.32994540
123MP0006082_CNS_inflammation0.32834057
124MP0001853_heart_inflammation0.31409861
125MP0001243_abnormal_dermal_layer0.31326998
126MP0000249_abnormal_blood_vessel0.31005344
127MP0002796_impaired_skin_barrier0.30804805
128MP0000230_abnormal_systemic_arterial0.30762654
129MP0002970_abnormal_white_adipose0.30386866
130MP0004883_abnormal_blood_vessel0.30300130
131MP0002168_other_aberrant_phenotype0.29630204
132MP0009384_cardiac_valve_regurgitation0.28943667
133MP0001881_abnormal_mammary_gland0.27650860
134MP0001845_abnormal_inflammatory_respons0.26217012
135MP0002132_abnormal_respiratory_system0.24956654
136MP0005164_abnormal_response_to0.23239677
137MP0002060_abnormal_skin_morphology0.22758820
138MP0000427_abnormal_hair_cycle0.22469210

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)7.42234773
2Abnormality of aromatic amino acid family metabolism (HP:0004338)7.32605902
3Intrahepatic cholestasis (HP:0001406)7.27824808
4Abnormality of monocarboxylic acid metabolism (HP:0010996)6.61014173
5Prolonged partial thromboplastin time (HP:0003645)6.60692346
6Hypobetalipoproteinemia (HP:0003563)6.51283116
7Xanthomatosis (HP:0000991)6.33159559
8Hyperlipoproteinemia (HP:0010980)5.73136488
9Complement deficiency (HP:0004431)5.33841091
10Hypolipoproteinemia (HP:0010981)4.85767132
11Joint hemorrhage (HP:0005261)4.76299398
12Hyperammonemia (HP:0001987)4.60755824
13Epidermoid cyst (HP:0200040)4.51946949
14Abnormality of the common coagulation pathway (HP:0010990)4.50194108
15Hyperglycinemia (HP:0002154)4.47386430
16Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.44499964
17Ketosis (HP:0001946)4.29363472
18Hypoalphalipoproteinemia (HP:0003233)4.28877804
19Abnormality of methionine metabolism (HP:0010901)4.25126459
20Abnormality of sulfur amino acid metabolism (HP:0004339)4.18166201
21Fat malabsorption (HP:0002630)4.12133813
22Abnormality of aspartate family amino acid metabolism (HP:0010899)4.08209412
23Abnormality of glutamine family amino acid metabolism (HP:0010902)3.98536648
24Hypoglycemic coma (HP:0001325)3.92770018
25Abnormality of glycine metabolism (HP:0010895)3.90857377
26Abnormality of serine family amino acid metabolism (HP:0010894)3.90857377
27Abnormality of complement system (HP:0005339)3.89356472
28Hyperglycinuria (HP:0003108)3.89033440
29Abnormality of pyrimidine metabolism (HP:0004353)3.78628298
30Abnormality of the intrinsic pathway (HP:0010989)3.76966724
31Conjugated hyperbilirubinemia (HP:0002908)3.74877031
32Hypercholesterolemia (HP:0003124)3.62672732
33Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.44525591
34Abnormality of fatty-acid metabolism (HP:0004359)3.40456696
35Hyperbilirubinemia (HP:0002904)3.34306710
36Osteomalacia (HP:0002749)3.29121791
37Spontaneous abortion (HP:0005268)3.15488879
38Delayed CNS myelination (HP:0002188)3.13820135
39Steatorrhea (HP:0002570)3.12738115
40Abnormality of serum amino acid levels (HP:0003112)3.05726278
41Abnormality of nucleobase metabolism (HP:0010932)3.04574682
42Ketoacidosis (HP:0001993)3.03663748
43Hypochromic microcytic anemia (HP:0004840)3.01453963
44Hepatocellular carcinoma (HP:0001402)2.94201058
45Myocardial infarction (HP:0001658)2.92363512
46Skin nodule (HP:0200036)2.77835223
47Metabolic acidosis (HP:0001942)2.76412335
48Systemic lupus erythematosus (HP:0002725)2.72304539
49Abnormality of purine metabolism (HP:0004352)2.67547874
50Abnormality of dicarboxylic acid metabolism (HP:0010995)2.61371936
51Dicarboxylic aciduria (HP:0003215)2.61371936
52Lethargy (HP:0001254)2.59563479
53Hypoglycemic seizures (HP:0002173)2.54425788
54Vascular calcification (HP:0004934)2.54049130
55Cholecystitis (HP:0001082)2.51025930
56Abnormal gallbladder physiology (HP:0012438)2.51025930
57Spastic diplegia (HP:0001264)2.47693508
58Abnormal gallbladder morphology (HP:0012437)2.47057052
59Acanthocytosis (HP:0001927)2.45645929
60Cholelithiasis (HP:0001081)2.43416436
61Gout (HP:0001997)2.39524566
62Glomerulonephritis (HP:0000099)2.38553912
63Cerebral edema (HP:0002181)2.36397878
64Mitral stenosis (HP:0001718)2.34748211
65Recurrent gram-negative bacterial infections (HP:0005420)2.34300187
66Malnutrition (HP:0004395)2.33895591
67Glycosuria (HP:0003076)2.33135651
68Abnormality of urine glucose concentration (HP:0011016)2.33135651
69Reduced antithrombin III activity (HP:0001976)2.32496673
70Hyperphosphaturia (HP:0003109)2.32449771
71Irritability (HP:0000737)2.32125570
72Neonatal onset (HP:0003623)2.31258170
73Amyloidosis (HP:0011034)2.31151763
74Bifid scrotum (HP:0000048)2.27500775
75Cardiovascular calcification (HP:0011915)2.24817337
76Gingival bleeding (HP:0000225)2.23968595
77Arthropathy (HP:0003040)2.23857785
78Sensorimotor neuropathy (HP:0007141)2.19721686
79Brushfield spots (HP:0001088)2.18935191
80Late onset (HP:0003584)2.17817746
81Esophageal varix (HP:0002040)2.17302592
82Pancreatitis (HP:0001733)2.14819868
83Menorrhagia (HP:0000132)2.13172128
84Enlarged kidneys (HP:0000105)2.11489767
85Abnormal biliary tract physiology (HP:0012439)2.11097021
86Bile duct proliferation (HP:0001408)2.11097021
87Thrombophlebitis (HP:0004418)2.09613591
88Hyperinsulinemic hypoglycemia (HP:0000825)2.06457985
89Vomiting (HP:0002013)2.06012520
90Opisthotonus (HP:0002179)2.05892175
91Generalized aminoaciduria (HP:0002909)2.03960412
92Hemorrhage of the eye (HP:0011885)2.01329271
93Abnormality of the gallbladder (HP:0005264)2.00590953
94Poikilocytosis (HP:0004447)1.98415493
95Increased serum pyruvate (HP:0003542)1.94957535
96Rickets (HP:0002748)1.91419719
97Abnormality of iron homeostasis (HP:0011031)1.89167878
98Renal cortical cysts (HP:0000803)1.88642491
99Abnormal urine phosphate concentration (HP:0012599)1.87317924
100Abnormality of transition element cation homeostasis (HP:0011030)1.86105185
101Purpura (HP:0000979)1.85865113
102Status epilepticus (HP:0002133)1.85699531
103Abnormal cartilage morphology (HP:0002763)1.84261123
104Hypophosphatemic rickets (HP:0004912)1.83675705
105Hydroxyprolinuria (HP:0003080)1.83280312
106Abnormality of proline metabolism (HP:0010907)1.83280312
107Elevated hepatic transaminases (HP:0002910)1.82201355
108Fair hair (HP:0002286)1.77704790
109Hyperglycemia (HP:0003074)1.77389286
110Pulmonary embolism (HP:0002204)1.75984107
111Abnormal enzyme/coenzyme activity (HP:0012379)1.74749541
112Abnormality of vitamin metabolism (HP:0100508)1.74722603
113Reticulocytosis (HP:0001923)1.73700197
114Abnormality of alanine metabolism (HP:0010916)1.72349936
115Hyperalaninemia (HP:0003348)1.72349936
116Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.72349936
117Nephritis (HP:0000123)1.70277491
118Acute encephalopathy (HP:0006846)1.65587150
119Birth length less than 3rd percentile (HP:0003561)1.64307622
120Neoplasm of the liver (HP:0002896)1.59548292
121Abnormality of alkaline phosphatase activity (HP:0004379)1.56179994
122Abnormality of glycolysis (HP:0004366)1.55187806
123Pancreatic islet-cell hyperplasia (HP:0004510)1.54306593
124Elevated alkaline phosphatase (HP:0003155)1.53261865
125Increased serum ferritin (HP:0003281)1.51318692
126Facial shape deformation (HP:0011334)1.50363980
127Potter facies (HP:0002009)1.50363980

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK7.17724402
2SIK14.67328965
3ERN14.62568078
4FGFR44.57182767
5STK163.73767984
6BRSK23.11594943
7TAOK33.10705906
8INSRR2.93631875
9ERBB42.90367977
10WNK42.67253202
11MAP2K42.50173198
12CDC72.44234843
13ZAK2.40424510
14TTK2.24653358
15PKN22.20480327
16EEF2K2.02965611
17MST1R2.02808202
18FLT31.91218829
19CDK121.90396447
20PIK3CG1.86477086
21MAPK111.81378748
22LATS11.80169168
23TRIB31.74654627
24DYRK21.69995684
25TYK21.61485920
26TAF11.57930522
27PNCK1.56216434
28DAPK21.53659497
29TLK11.53421943
30PLK41.49617704
31WNK31.49512248
32ABL21.47019953
33PTK61.41192962
34BRSK11.40309048
35NME11.39582261
36NEK91.38229434
37VRK21.37471193
38EIF2AK31.35593772
39CAMKK21.32127398
40KDR1.31166420
41FGFR21.30018880
42JAK21.21043998
43FRK1.19668226
44TNIK1.18707519
45MAP3K71.15987980
46MAP4K21.15081008
47PINK11.12650054
48MAP2K31.10653606
49PRKAA21.09331365
50GRK61.07802295
51MAPKAPK31.06709971
52PLK31.06482081
53TBK11.04384734
54PAK21.04277624
55MAPK41.03433186
56JAK11.00406918
57CDK71.00332561
58MAP3K100.97832784
59MAP3K140.97015353
60ERBB20.96989408
61SRPK10.96783061
62BCR0.95922268
63STK38L0.93941935
64NTRK30.93573183
65PRKCZ0.93424044
66ADRBK20.92854595
67CHEK20.91226722
68NEK20.91037273
69WEE10.90703152
70TSSK60.90524372
71CSNK1E0.87515244
72MAP3K30.87198539
73MAPK120.85955570
74CDK60.85732659
75EPHB10.84620945
76MET0.83544980
77PLK10.83416031
78MAP3K110.83155800
79CSNK2A10.82535649
80BMPR1B0.81459974
81MAP3K40.79830576
82MAPK150.78878492
83MUSK0.78626481
84TIE10.76142621
85ATR0.75552832
86FGFR10.75173769
87CSNK2A20.75158443
88PRKACG0.75082879
89RIPK10.73809081
90DYRK1B0.73080685
91EPHA30.73072564
92EIF2AK10.72958034
93MAPKAPK50.71159098
94NEK10.70392677
95CSK0.70369598
96NUAK10.70042775
97CAMK2G0.69186198
98CSNK1D0.68730077
99CDK80.68310956
100GSK3A0.66997739
101VRK10.66905053
102IRAK30.66073799
103SGK30.64884035
104MAP2K60.63616749
105FGFR30.63387457
106TYRO30.63225503
107PRKAA10.63001820
108CAMK1D0.62761229
109EPHA40.61778919
110ATM0.61394835
111KSR20.60765588
112MAPK70.60438837
113PRKACA0.60378492
114TGFBR20.58544271
115MAP2K70.56962622
116AKT20.56892138
117WNK10.55633349
118PTK20.53792183
119MAP3K60.52464877
120CSF1R0.52112415
121MAP3K50.51272555
122NLK0.50468353
123PRKG10.50317857
124PRKCQ0.50278895
125IKBKE0.50158445
126SGK20.49701738
127CDK10.49141147
128PDPK10.47334821
129BUB10.46683556
130TAOK20.46594640
131IGF1R0.44733082
132CSNK1G10.43299208
133RET0.43267807
134CSNK1A10.43160170
135ACVR1B0.42813949
136CDK40.42717851
137MAP3K130.42668921
138PRKDC0.42543350
139LATS20.41573637
140PRKCG0.40682792
141MAP2K10.40675123
142PRKACB0.40104847
143RPS6KA50.40046188
144GRK10.39275584
145ICK0.38880244
146RPS6KB20.38690082
147PKN10.38375206
148RPS6KA30.38155325
149PRKCI0.37662617
150CAMK40.34762857
151MTOR0.33533821
152SGK4940.33170801
153SGK2230.33170801
154EGFR0.32533995
155PDK10.29458419
156IRAK20.29010881
157IRAK10.28477338
158MAP3K10.27153762
159AKT30.26742181
160PRKCA0.25953050
161PBK0.25546397
162CSNK1G20.23688034
163PDK30.22179792
164PDK40.22179792
165PIK3CA0.21791184
166ABL10.21713162
167CAMK1G0.21178319
168BMX0.21127256

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.56519403
2Nitrogen metabolism_Homo sapiens_hsa009103.50830468
3Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.36790648
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.30815884
5Arginine biosynthesis_Homo sapiens_hsa002203.01599825
6Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.82769795
7Complement and coagulation cascades_Homo sapiens_hsa046102.76425742
8Tryptophan metabolism_Homo sapiens_hsa003802.69122808
9Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.63447967
10Fatty acid degradation_Homo sapiens_hsa000712.57016618
11Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.51062341
12Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.42559244
13Pentose and glucuronate interconversions_Homo sapiens_hsa000402.25835179
14Butanoate metabolism_Homo sapiens_hsa006502.20567551
15Peroxisome_Homo sapiens_hsa041462.10829779
16Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.10432760
17Propanoate metabolism_Homo sapiens_hsa006401.93663021
18Steroid hormone biosynthesis_Homo sapiens_hsa001401.93402984
19PPAR signaling pathway_Homo sapiens_hsa033201.92329811
20Chemical carcinogenesis_Homo sapiens_hsa052041.92244834
21Histidine metabolism_Homo sapiens_hsa003401.90367344
22Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.90321690
23Fatty acid metabolism_Homo sapiens_hsa012121.88219268
24Drug metabolism - other enzymes_Homo sapiens_hsa009831.76612599
25Staphylococcus aureus infection_Homo sapiens_hsa051501.75213253
26beta-Alanine metabolism_Homo sapiens_hsa004101.74858171
27Retinol metabolism_Homo sapiens_hsa008301.72762292
28Caffeine metabolism_Homo sapiens_hsa002321.71846018
29Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.71639637
30Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.69969089
31Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.69121127
32Phenylalanine metabolism_Homo sapiens_hsa003601.53777860
33Selenocompound metabolism_Homo sapiens_hsa004501.51838214
34Bile secretion_Homo sapiens_hsa049761.50684749
352-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.49482768
36Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.46072587
37Tyrosine metabolism_Homo sapiens_hsa003501.43183243
38Fatty acid elongation_Homo sapiens_hsa000621.40254350
39Pyruvate metabolism_Homo sapiens_hsa006201.38095016
40Sulfur metabolism_Homo sapiens_hsa009201.30068371
41Cysteine and methionine metabolism_Homo sapiens_hsa002701.29566890
42Starch and sucrose metabolism_Homo sapiens_hsa005001.27122786
43Folate biosynthesis_Homo sapiens_hsa007901.20822967
44ABC transporters_Homo sapiens_hsa020101.20134584
45Fat digestion and absorption_Homo sapiens_hsa049751.17653012
46Biosynthesis of amino acids_Homo sapiens_hsa012301.17246944
47Carbon metabolism_Homo sapiens_hsa012001.11896820
48Steroid biosynthesis_Homo sapiens_hsa001001.09886968
49Maturity onset diabetes of the young_Homo sapiens_hsa049501.02615518
50Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.99169787
51Vitamin B6 metabolism_Homo sapiens_hsa007500.97681476
52Cyanoamino acid metabolism_Homo sapiens_hsa004600.97091685
53Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.96943308
54Arginine and proline metabolism_Homo sapiens_hsa003300.96693151
55Sulfur relay system_Homo sapiens_hsa041220.95627964
56Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.85921039
57Vitamin digestion and absorption_Homo sapiens_hsa049770.84868897
58Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.83803116
59Lysine degradation_Homo sapiens_hsa003100.83203215
60One carbon pool by folate_Homo sapiens_hsa006700.74681693
61Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.70592301
62Glycerolipid metabolism_Homo sapiens_hsa005610.69227996
63Glutathione metabolism_Homo sapiens_hsa004800.60332715
64Pentose phosphate pathway_Homo sapiens_hsa000300.56212151
65Fatty acid biosynthesis_Homo sapiens_hsa000610.55538339
66Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.50472829
67Metabolic pathways_Homo sapiens_hsa011000.45520330
68Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.45242977
69Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.43956900
70Prion diseases_Homo sapiens_hsa050200.36658445
71alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.27953608
72Galactose metabolism_Homo sapiens_hsa000520.24221369
73Insulin resistance_Homo sapiens_hsa049310.24120648
74Fructose and mannose metabolism_Homo sapiens_hsa000510.23585034
75Linoleic acid metabolism_Homo sapiens_hsa005910.23365064
76Adipocytokine signaling pathway_Homo sapiens_hsa049200.23126758
77Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.17443945
78Glycerophospholipid metabolism_Homo sapiens_hsa005640.16072017
79N-Glycan biosynthesis_Homo sapiens_hsa005100.15366530
80RNA polymerase_Homo sapiens_hsa030200.14929410
81Protein export_Homo sapiens_hsa030600.13180128
82Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.11811805
83Glucagon signaling pathway_Homo sapiens_hsa049220.11762218
84Ribosome_Homo sapiens_hsa030100.08985111
85DNA replication_Homo sapiens_hsa030300.08010272
86Ether lipid metabolism_Homo sapiens_hsa005650.07525056
87Oxidative phosphorylation_Homo sapiens_hsa001900.06129628
88Pyrimidine metabolism_Homo sapiens_hsa002400.05384492
89Homologous recombination_Homo sapiens_hsa034400.04950943
90AMPK signaling pathway_Homo sapiens_hsa041520.02439996
91Circadian rhythm_Homo sapiens_hsa047100.01529292
92Bladder cancer_Homo sapiens_hsa05219-0.2455432
93Amoebiasis_Homo sapiens_hsa05146-0.2406783
94Longevity regulating pathway - mammal_Homo sapiens_hsa04211-0.2383736
95Longevity regulating pathway - multiple species_Homo sapiens_hsa04213-0.2357363
96Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.2289752
97Renin-angiotensin system_Homo sapiens_hsa04614-0.2068861
98Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141-0.1986308
99Thyroid hormone synthesis_Homo sapiens_hsa04918-0.1922643
100Hepatitis C_Homo sapiens_hsa05160-0.1744608
101Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.1647799
102Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604-0.1631430
103Arachidonic acid metabolism_Homo sapiens_hsa00590-0.1617081
104Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.1495507
105Systemic lupus erythematosus_Homo sapiens_hsa05322-0.1482204
106Regulation of autophagy_Homo sapiens_hsa04140-0.1462761
107African trypanosomiasis_Homo sapiens_hsa05143-0.1310485
108Insulin signaling pathway_Homo sapiens_hsa04910-0.1015619
109Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.0891671
110Ovarian steroidogenesis_Homo sapiens_hsa04913-0.0710182
111Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534-0.0591481
112Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932-0.0331094
113Parkinsons disease_Homo sapiens_hsa05012-0.0316232
114Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008-0.0221813
115Pertussis_Homo sapiens_hsa05133-0.0163566
116Mismatch repair_Homo sapiens_hsa03430-0.0151798

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