INMT

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: N-methylation of endogenous and xenobiotic compounds is a major method by which they are degraded. This gene encodes an enzyme that N-methylates indoles such as tryptamine. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the downstream FAM188B (family with sequence similarity 188, member B) gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1L-phenylalanine catabolic process (GO:0006559)7.16990247
2erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.16990247
3L-phenylalanine metabolic process (GO:0006558)6.89273075
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.89273075
5aromatic amino acid family catabolic process (GO:0009074)6.42061917
6tryptophan catabolic process (GO:0006569)5.74518351
7indole-containing compound catabolic process (GO:0042436)5.74518351
8indolalkylamine catabolic process (GO:0046218)5.74518351
9glyoxylate metabolic process (GO:0046487)5.64718128
10bile acid biosynthetic process (GO:0006699)5.55804941
11kynurenine metabolic process (GO:0070189)5.47177581
12tryptophan metabolic process (GO:0006568)5.41761611
13cysteine metabolic process (GO:0006534)5.40814592
14triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.33959237
15complement activation, alternative pathway (GO:0006957)5.33812644
16alpha-linolenic acid metabolic process (GO:0036109)5.32683474
17negative regulation of fibrinolysis (GO:0051918)5.30388544
18homocysteine metabolic process (GO:0050667)5.26714993
19sulfur amino acid catabolic process (GO:0000098)5.23914785
20urea cycle (GO:0000050)5.09964347
21urea metabolic process (GO:0019627)5.09964347
22regulation of protein activation cascade (GO:2000257)5.06319196
23fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.96995714
24drug catabolic process (GO:0042737)4.96583101
25behavioral response to nicotine (GO:0035095)4.95650265
26lysine catabolic process (GO:0006554)4.92502811
27lysine metabolic process (GO:0006553)4.92502811
28regulation of fibrinolysis (GO:0051917)4.92083503
29protein carboxylation (GO:0018214)4.91281375
30peptidyl-glutamic acid carboxylation (GO:0017187)4.91281375
31regulation of complement activation (GO:0030449)4.84948876
32serine family amino acid catabolic process (GO:0009071)4.80940546
33high-density lipoprotein particle remodeling (GO:0034375)4.76322976
34exogenous drug catabolic process (GO:0042738)4.74400917
35nitrogen cycle metabolic process (GO:0071941)4.70315655
36bile acid metabolic process (GO:0008206)4.66260415
37aromatic amino acid family metabolic process (GO:0009072)4.63613391
38ethanol oxidation (GO:0006069)4.55155618
39amino-acid betaine metabolic process (GO:0006577)4.46832827
40tyrosine metabolic process (GO:0006570)4.41829480
41alpha-amino acid catabolic process (GO:1901606)4.41459715
42urate metabolic process (GO:0046415)4.26920750
43cellular ketone body metabolic process (GO:0046950)4.25557941
44regulation of triglyceride catabolic process (GO:0010896)4.22700115
45drug metabolic process (GO:0017144)4.19251782
46L-fucose catabolic process (GO:0042355)4.15394819
47fucose catabolic process (GO:0019317)4.15394819
48L-fucose metabolic process (GO:0042354)4.15394819
49benzene-containing compound metabolic process (GO:0042537)4.14321505
50cellular amino acid catabolic process (GO:0009063)4.11665186
51drug transmembrane transport (GO:0006855)4.08943162
52reverse cholesterol transport (GO:0043691)4.08755370
53regulation of cholesterol esterification (GO:0010872)4.05512890
54acylglycerol homeostasis (GO:0055090)4.04724698
55triglyceride homeostasis (GO:0070328)4.04724698
56negative regulation of cholesterol transport (GO:0032375)4.04449739
57negative regulation of sterol transport (GO:0032372)4.04449739
58protein-lipid complex remodeling (GO:0034368)4.03951216
59macromolecular complex remodeling (GO:0034367)4.03951216
60plasma lipoprotein particle remodeling (GO:0034369)4.03951216
61coenzyme catabolic process (GO:0009109)4.03388648
62indolalkylamine metabolic process (GO:0006586)4.02810049
63cellular glucuronidation (GO:0052695)4.01905016
64cellular modified amino acid catabolic process (GO:0042219)4.00124969
65glutamate metabolic process (GO:0006536)3.97891302
66aldehyde catabolic process (GO:0046185)3.97591703
67serine family amino acid metabolic process (GO:0009069)3.96398206
68bile acid and bile salt transport (GO:0015721)3.95608574
69plasma lipoprotein particle clearance (GO:0034381)3.93562569
70amine catabolic process (GO:0009310)3.90189511
71cellular biogenic amine catabolic process (GO:0042402)3.90189511
72epoxygenase P450 pathway (GO:0019373)3.88877205
73short-chain fatty acid metabolic process (GO:0046459)3.88095777
74imidazole-containing compound metabolic process (GO:0052803)3.85071494
75glycine metabolic process (GO:0006544)3.84067415
76phospholipid efflux (GO:0033700)3.75876741
77acetyl-CoA metabolic process (GO:0006084)3.71315694
78arginine metabolic process (GO:0006525)3.70918731
79cholesterol efflux (GO:0033344)3.69025207
80fibrinolysis (GO:0042730)3.68353560
81flavonoid metabolic process (GO:0009812)3.68204706
82carboxylic acid catabolic process (GO:0046395)3.67385768
83organic acid catabolic process (GO:0016054)3.67385768
84uronic acid metabolic process (GO:0006063)3.66789715
85glucuronate metabolic process (GO:0019585)3.66789715
86ketone body metabolic process (GO:1902224)3.66605830
87dicarboxylic acid biosynthetic process (GO:0043650)3.65150498
88regulation of cholesterol homeostasis (GO:2000188)3.62287848
89regulation of bile acid biosynthetic process (GO:0070857)3.60002661
90serine family amino acid biosynthetic process (GO:0009070)3.57135218
91fatty acid beta-oxidation (GO:0006635)3.56308129
92complement activation, classical pathway (GO:0006958)3.55790869
93fatty acid oxidation (GO:0019395)3.54052127
94response to nitrosative stress (GO:0051409)3.53413245
95aspartate family amino acid catabolic process (GO:0009068)3.53300293
96complement activation (GO:0006956)3.52441780
97cytolysis (GO:0019835)3.51522991
98monocarboxylic acid catabolic process (GO:0072329)3.49580558
99ethanol metabolic process (GO:0006067)3.48498427
100cholesterol homeostasis (GO:0042632)3.48231767
101regulation of hippo signaling (GO:0035330)3.48126358
102lipid oxidation (GO:0034440)3.46981057
1032-oxoglutarate metabolic process (GO:0006103)3.44563053
104sterol homeostasis (GO:0055092)3.44020980
105cofactor catabolic process (GO:0051187)3.40055556
106toxin metabolic process (GO:0009404)3.29058351
107neuronal action potential (GO:0019228)3.09414076
108nephron epithelium morphogenesis (GO:0072088)3.06590598
109nephron tubule morphogenesis (GO:0072078)3.06590598
110pyrimidine nucleobase catabolic process (GO:0006208)3.01668700
111response to pheromone (GO:0019236)3.01548240
112positive regulation of phosphoprotein phosphatase activity (GO:0032516)3.00585178
113sulfation (GO:0051923)2.98565427
114epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.97103081
115dopamine transport (GO:0015872)2.96144544
116surfactant homeostasis (GO:0043129)2.95778872
117platelet dense granule organization (GO:0060155)2.94894380
118indole-containing compound metabolic process (GO:0042430)2.90615009
119membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.89043953
120negative regulation of systemic arterial blood pressure (GO:0003085)2.87540887
121detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.86162639
122regulation of endothelial cell differentiation (GO:0045601)2.84191174
123chemical homeostasis within a tissue (GO:0048875)2.76053698
124detection of light stimulus involved in sensory perception (GO:0050962)2.74801023
125detection of light stimulus involved in visual perception (GO:0050908)2.74801023
126negative regulation of mast cell activation (GO:0033004)2.74420235
127renal tubule morphogenesis (GO:0061333)2.72282204
128phosphatidylinositol acyl-chain remodeling (GO:0036149)2.71189077
129gamma-aminobutyric acid transport (GO:0015812)2.70964650
130negative regulation of cytosolic calcium ion concentration (GO:0051481)2.69080796
131negative regulation of synaptic transmission, GABAergic (GO:0032229)2.65496697
132positive regulation of digestive system process (GO:0060456)2.63314268
133primary amino compound metabolic process (GO:1901160)2.60066112
134water-soluble vitamin biosynthetic process (GO:0042364)2.59151950
135lymphangiogenesis (GO:0001946)2.58726440
136DNA deamination (GO:0045006)2.58168917
137serotonin metabolic process (GO:0042428)2.55241516
138reflex (GO:0060004)2.55041306
139behavioral response to ethanol (GO:0048149)2.52338412
140peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)2.51062985
141regulation of action potential (GO:0098900)2.50540989
142nucleobase catabolic process (GO:0046113)2.48615557
143positive regulation of fatty acid transport (GO:2000193)2.48070916
144transepithelial transport (GO:0070633)2.47893083
145regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.46726360
146neurotransmitter metabolic process (GO:0042133)2.45760055
147membrane depolarization during action potential (GO:0086010)2.42515340
148epithelial cilium movement (GO:0003351)2.41894363
149auditory receptor cell stereocilium organization (GO:0060088)2.39727688
150atrial cardiac muscle cell action potential (GO:0086014)2.38911217
151positive regulation of action potential (GO:0045760)2.38390292
152inner ear receptor stereocilium organization (GO:0060122)2.37977787
153dopamine biosynthetic process (GO:0042416)2.37302138
154negative regulation of telomere maintenance (GO:0032205)2.35276052
155kidney morphogenesis (GO:0060993)2.34575606
156action potential (GO:0001508)2.34167202
157cAMP catabolic process (GO:0006198)2.33494737
158thyroid hormone metabolic process (GO:0042403)2.31307488
159smooth muscle tissue development (GO:0048745)2.31195444
160regulation of mesoderm development (GO:2000380)2.30158649
161synaptic transmission, cholinergic (GO:0007271)2.28792931
162one-carbon compound transport (GO:0019755)2.28658357
163nonmotile primary cilium assembly (GO:0035058)2.27966515
164axoneme assembly (GO:0035082)2.25781580
165norepinephrine metabolic process (GO:0042415)2.23740540
166cilium movement (GO:0003341)2.22312547
167phosphatidylglycerol acyl-chain remodeling (GO:0036148)2.22072574
168membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.21444798
169mitochondrial respiratory chain complex I assembly (GO:0032981)2.20878662
170NADH dehydrogenase complex assembly (GO:0010257)2.20878662
171mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.20878662
172cyclic nucleotide catabolic process (GO:0009214)2.19989312
173protein complex biogenesis (GO:0070271)2.19473363
174parturition (GO:0007567)2.18356727
175rhodopsin mediated signaling pathway (GO:0016056)2.16491233
176regulation of gene silencing by RNA (GO:0060966)2.16251112
177regulation of posttranscriptional gene silencing (GO:0060147)2.16251112
178regulation of gene silencing by miRNA (GO:0060964)2.16251112
179regulation of rhodopsin mediated signaling pathway (GO:0022400)2.15780003
180sulfate transmembrane transport (GO:1902358)2.14735626
181protein polyglutamylation (GO:0018095)2.14615254
182fucosylation (GO:0036065)2.13429595
183regulation of membrane repolarization (GO:0060306)2.12832938
184somite development (GO:0061053)2.12634871
185neuron maturation (GO:0042551)2.12352938
186positive regulation of icosanoid secretion (GO:0032305)2.12111513

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RXR_22158963_ChIP-Seq_LIVER_Mouse7.69581533
2PPARA_22158963_ChIP-Seq_LIVER_Mouse6.57632227
3EGR1_23403033_ChIP-Seq_LIVER_Mouse6.12049426
4LXR_22158963_ChIP-Seq_LIVER_Mouse6.06838370
5PPARG_19300518_ChIP-PET_3T3-L1_Mouse5.40537670
6FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.74236490
7* CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.37156499
8EZH2_22144423_ChIP-Seq_EOC_Human3.91534577
9NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.77320550
10FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.64860104
11CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.48845825
12ZNF274_21170338_ChIP-Seq_K562_Hela3.06926172
13VDR_22108803_ChIP-Seq_LS180_Human2.94959983
14GBX2_23144817_ChIP-Seq_PC3_Human2.94249317
15GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.47273974
16ZFP57_27257070_Chip-Seq_ESCs_Mouse2.34029118
17* CLOCK_20551151_ChIP-Seq_293T_Human2.27633159
18TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.09598046
19ESR1_17901129_ChIP-ChIP_LIVER_Mouse10.7983936
20TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.95829443
21HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.94260523
22HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.94246318
23POU3F2_20337985_ChIP-ChIP_501MEL_Human1.92210153
24CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.89404801
25IGF1R_20145208_ChIP-Seq_DFB_Human1.85416285
26CTBP2_25329375_ChIP-Seq_LNCAP_Human1.85361890
27FLI1_27457419_Chip-Seq_LIVER_Mouse1.83635672
28PIAS1_25552417_ChIP-Seq_VCAP_Human1.76724435
29TAF15_26573619_Chip-Seq_HEK293_Human1.72661287
30P300_19829295_ChIP-Seq_ESCs_Human1.72609464
31CTBP1_25329375_ChIP-Seq_LNCAP_Human1.72385958
32AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.66174821
33TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.64659678
34EED_16625203_ChIP-ChIP_MESCs_Mouse1.64651328
35CBX2_27304074_Chip-Seq_ESCs_Mouse1.63036173
36FOXA2_19822575_ChIP-Seq_HepG2_Human1.60270159
37PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.59778983
38SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.59722724
39TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.57730330
40* RARG_19884340_ChIP-ChIP_MEFs_Mouse1.55461010
41EWS_26573619_Chip-Seq_HEK293_Human1.53453428
42BMI1_23680149_ChIP-Seq_NPCS_Mouse1.51316496
43SMAD4_21799915_ChIP-Seq_A2780_Human1.50245642
44ER_23166858_ChIP-Seq_MCF-7_Human1.49911347
45SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.49795234
46FUS_26573619_Chip-Seq_HEK293_Human1.47838561
47AR_21572438_ChIP-Seq_LNCaP_Human1.46583455
48STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.46328972
49PCGF2_27294783_Chip-Seq_ESCs_Mouse1.45486280
50AR_25329375_ChIP-Seq_VCAP_Human1.43562490
51STAT3_23295773_ChIP-Seq_U87_Human1.43237861
52NR3C1_21868756_ChIP-Seq_MCF10A_Human1.42702928
53UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.41135502
54THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.39425637
55SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.36772515
56SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.36517326
57EZH2_27304074_Chip-Seq_ESCs_Mouse1.34956149
58IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.33776766
59SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.33410265
60EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.32882467
61PCGF2_27294783_Chip-Seq_NPCs_Mouse1.32767018
62JARID2_20075857_ChIP-Seq_MESCs_Mouse1.32128342
63EZH2_27294783_Chip-Seq_ESCs_Mouse1.30824804
64SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.29595789
65HNF4A_19822575_ChIP-Seq_HepG2_Human1.29520248
66RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.28997217
67TCF4_23295773_ChIP-Seq_U87_Human1.28851451
68TRIM28_21343339_ChIP-Seq_HEK293_Human1.28109673
69JARID2_20064375_ChIP-Seq_MESCs_Mouse1.26616531
70SMAD3_21741376_ChIP-Seq_EPCs_Human1.26422101
71SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.26290726
72MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.25806118
73PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.25031049
74RNF2_27304074_Chip-Seq_NSC_Mouse1.21652990
75ESR2_21235772_ChIP-Seq_MCF-7_Human1.21259820
76TOP2B_26459242_ChIP-Seq_MCF-7_Human1.21009218
77MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.20475881
78* GATA1_22025678_ChIP-Seq_K562_Human1.20104052
79REST_21632747_ChIP-Seq_MESCs_Mouse1.20066318
80TP53_16413492_ChIP-PET_HCT116_Human1.19905032
81SOX2_27498859_Chip-Seq_STOMACH_Mouse1.18709807
82IRF1_19129219_ChIP-ChIP_H3396_Human1.17227582
83SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.17053160
84SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.16158495
85ESR1_21235772_ChIP-Seq_MCF-7_Human1.16116160
86EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.16090949
87SUZ12_27294783_Chip-Seq_NPCs_Mouse1.15432721
88HTT_18923047_ChIP-ChIP_STHdh_Human1.15170725
89NANOG_19829295_ChIP-Seq_ESCs_Human1.14715171
90SOX2_19829295_ChIP-Seq_ESCs_Human1.14715171
91CBP_20019798_ChIP-Seq_JUKART_Human1.14645089
92IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.14645089
93TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.14480539
94POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.14480539
95SUZ12_27294783_Chip-Seq_ESCs_Mouse1.14350418
96RUNX2_22187159_ChIP-Seq_PCA_Human1.14250094
97TCF4_22108803_ChIP-Seq_LS180_Human1.13858059
98RNF2_27304074_Chip-Seq_ESCs_Mouse1.13856776
99EP300_21415370_ChIP-Seq_HL-1_Mouse1.13451259
100OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.13329217
101SMAD4_21741376_ChIP-Seq_EPCs_Human1.12692825
102RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.12464513
103ETV2_25802403_ChIP-Seq_MESCs_Mouse1.12229755
104TP53_22573176_ChIP-Seq_HFKS_Human1.12191848
105RNF2_18974828_ChIP-Seq_MESCs_Mouse1.11565714
106EZH2_18974828_ChIP-Seq_MESCs_Mouse1.11565714
107EZH2_27294783_Chip-Seq_NPCs_Mouse1.10888882
108BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.09856292
109FOXA1_27270436_Chip-Seq_PROSTATE_Human1.09608295
110FOXA1_25329375_ChIP-Seq_VCAP_Human1.09608295
111MTF2_20144788_ChIP-Seq_MESCs_Mouse1.09556979
112NFE2_27457419_Chip-Seq_LIVER_Mouse1.08314147
113* DROSHA_22980978_ChIP-Seq_HELA_Human1.07389757
114ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.07327697
115ARNT_22903824_ChIP-Seq_MCF-7_Human1.06320344
116ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.04196641
117BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.04103103
118* GATA3_21878914_ChIP-Seq_MCF-7_Human1.03707279
119FLI1_21867929_ChIP-Seq_TH2_Mouse1.03208868
120CJUN_26792858_Chip-Seq_BT549_Human1.02311177
121GATA4_25053715_ChIP-Seq_YYC3_Human1.02065949
122SALL1_21062744_ChIP-ChIP_HESCs_Human1.00626566
123CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.00616281
124RXRA_24833708_ChIP-Seq_LIVER_Mouse1.00148378
125SALL4_18804426_ChIP-ChIP_XEN_Mouse1.00119127
126TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.99508496
127AHR_22903824_ChIP-Seq_MCF-7_Human0.99305976
128KDM2B_26808549_Chip-Seq_REH_Human0.98416077
129IRF8_22096565_ChIP-ChIP_GC-B_Human0.97764132
130KLF5_20875108_ChIP-Seq_MESCs_Mouse0.96879363
131STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.95058221
132RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.93694450
133Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.91212387
134ZNF263_19887448_ChIP-Seq_K562_Human0.90815008
135AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.88010601
136NRF2_20460467_ChIP-Seq_MEFs_Mouse0.85766582
137NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.85766582
138CDX2_20551321_ChIP-Seq_CACO-2_Human0.82596083
139GATA2_21666600_ChIP-Seq_HMVEC_Human0.81601114
140NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.81326073
141PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.80486143
142LXR_22292898_ChIP-Seq_THP-1_Human0.80168824
143ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.76968049
144ESR1_20079471_ChIP-ChIP_T-47D_Human0.76814700
145ESR1_15608294_ChIP-ChIP_MCF-7_Human0.76425889
146ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.75862839
147PPAR_26484153_Chip-Seq_NCI-H1993_Human0.74556853
148SOX2_20726797_ChIP-Seq_SW620_Human0.73196821
149* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.72945206
150FOXO3_23340844_ChIP-Seq_DLD1_Human0.72726689
151NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.70121989
152AUTS2_25519132_ChIP-Seq_293T-REX_Human0.67506732
153ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.67261315
154SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.64465087
155GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.64168298
156EGR1_19032775_ChIP-ChIP_M12_Human0.63861334
157* RAD21_21589869_ChIP-Seq_MESCs_Mouse0.63167604
158TBX20_22328084_ChIP-Seq_HEART_Mouse0.62843856
159TBX20_22080862_ChIP-Seq_HEART_Mouse0.62843856
160BCAT_22108803_ChIP-Seq_LS180_Human0.62591727
161ERG_21242973_ChIP-ChIP_JURKAT_Human0.62452242
162CEBPB_22108803_ChIP-Seq_LS180_Human0.62112893
163FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.61791988
164BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.60923558
165RACK7_27058665_Chip-Seq_MCF-7_Human0.59827384
166SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.57912414
167* GATA1_19941826_ChIP-Seq_K562_Human0.57770191
168RARA_24833708_ChIP-Seq_LIVER_Mouse0.57704437
169GATA2_19941826_ChIP-Seq_K562_Human0.56718714
170* KAP1_22055183_ChIP-Seq_ESCs_Mouse0.56088705
171STAT3_1855785_ChIP-Seq_MESCs_Mouse0.55831745
172* PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.55513668
173FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.55090585
174FOXA1_25552417_ChIP-Seq_VCAP_Human0.54801059
175SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.53611830
176GATA6_25053715_ChIP-Seq_YYC3_Human0.52649783
177PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.52643029
178FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.52380812
179* PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.52364229
180CSB_26484114_Chip-Seq_FIBROBLAST_Human0.51605266
181AR_20517297_ChIP-Seq_VCAP_Human0.51277264
182* MYC_19915707_ChIP-ChIP_AK7_Human0.50844165
183ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.50840714
184* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.50774028
185RARB_24833708_ChIP-Seq_LIVER_Mouse0.50747641
186CBP_21632823_ChIP-Seq_H3396_Human0.49577091
187PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.49138189
188GATA3_24758297_ChIP-Seq_MCF-7_Human0.49011340
189P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.46748683
190STAT1_17558387_ChIP-Seq_HELA_Human0.46122166
191ESET_19884257_ChIP-Seq_ESCs_Mouse0.46031032
192TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.45700712
193GATA1_19941827_ChIP-Seq_MEL_Mouse0.44958767
194GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.44651588
195CDX2_22108803_ChIP-Seq_LS180_Human0.43982550

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system7.94451914
2MP0005360_urolithiasis7.23013404
3MP0005085_abnormal_gallbladder_physiolo5.81759387
4MP0008875_abnormal_xenobiotic_pharmacok5.56834565
5MP0005365_abnormal_bile_salt5.55983372
6MP0003252_abnormal_bile_duct3.65429817
7MP0003806_abnormal_nucleotide_metabolis3.57501314
8MP0010329_abnormal_lipoprotein_level3.24789711
9MP0002138_abnormal_hepatobiliary_system3.18045874
10MP0005083_abnormal_biliary_tract3.00850425
11MP0005332_abnormal_amino_acid2.90785973
12MP0009840_abnormal_foam_cell2.73360239
13MP0003191_abnormal_cellular_cholesterol2.49440293
14MP0003195_calcinosis2.46885252
15MP0004019_abnormal_vitamin_homeostasis2.43032067
16MP0001666_abnormal_nutrient_absorption2.29932288
17MP0005551_abnormal_eye_electrophysiolog2.26051689
18MP0003136_yellow_coat_color2.20596857
19MP0005503_abnormal_tendon_morphology2.16297834
20MP0003283_abnormal_digestive_organ2.12856969
21MP0001986_abnormal_taste_sensitivity2.09206435
22MP0002118_abnormal_lipid_homeostasis1.99005268
23MP0002102_abnormal_ear_morphology1.96926566
24MP0000609_abnormal_liver_physiology1.92623671
25MP0002638_abnormal_pupillary_reflex1.90434843
26MP0003646_muscle_fatigue1.82764099
27MP0004782_abnormal_surfactant_physiolog1.79815428
28MP0010368_abnormal_lymphatic_system1.79108877
29MP0009046_muscle_twitch1.76839124
30MP0005319_abnormal_enzyme/_coenzyme1.76415311
31MP0001485_abnormal_pinna_reflex1.74529029
32MP0006276_abnormal_autonomic_nervous1.71922210
33MP0005377_hearing/vestibular/ear_phenot1.67733245
34MP0003878_abnormal_ear_physiology1.67733245
35MP0004145_abnormal_muscle_electrophysio1.65566256
36MP0001501_abnormal_sleep_pattern1.64687198
37MP0004133_heterotaxia1.64039663
38MP0002653_abnormal_ependyma_morphology1.64008209
39MP0009643_abnormal_urine_homeostasis1.63461818
40MP0004142_abnormal_muscle_tone1.59422402
41MP0005171_absent_coat_pigmentation1.56426688
42MP0003868_abnormal_feces_composition1.55528264
43MP0005584_abnormal_enzyme/coenzyme_acti1.54094471
44MP0006072_abnormal_retinal_apoptosis1.52967833
45MP0001968_abnormal_touch/_nociception1.51884873
46MP0002272_abnormal_nervous_system1.51315014
47MP0009745_abnormal_behavioral_response1.48844958
48MP0001764_abnormal_homeostasis1.47316369
49MP0005253_abnormal_eye_physiology1.45833207
50MP0004215_abnormal_myocardial_fiber1.43866210
51MP0008872_abnormal_physiological_respon1.43211228
52MP0000631_abnormal_neuroendocrine_gland1.40757190
53MP0003137_abnormal_impulse_conducting1.39087234
54MP0003186_abnormal_redox_activity1.37829363
55MP0004085_abnormal_heartbeat1.34922225
56MP0002733_abnormal_thermal_nociception1.34433735
57MP0004885_abnormal_endolymph1.34167266
58MP0008775_abnormal_heart_ventricle1.32392987
59MP0003705_abnormal_hypodermis_morpholog1.29668895
60MP0002736_abnormal_nociception_after1.23014544
61MP0001905_abnormal_dopamine_level1.20537397
62MP0009764_decreased_sensitivity_to1.20354229
63MP0010386_abnormal_urinary_bladder1.18694611
64MP0005636_abnormal_mineral_homeostasis1.14320653
65MP0003724_increased_susceptibility_to1.14151123
66MP0002557_abnormal_social/conspecific_i1.11758390
67MP0000569_abnormal_digit_pigmentation1.08043669
68MP0005451_abnormal_body_composition1.07995730
69MP0001958_emphysema1.07405418
70MP0001440_abnormal_grooming_behavior1.06900113
71MP0001970_abnormal_pain_threshold1.06555434
72MP0003011_delayed_dark_adaptation1.06389681
73MP0001984_abnormal_olfaction1.06147691
74MP0000598_abnormal_liver_morphology1.06072921
75MP0002064_seizures1.05838034
76MP0002909_abnormal_adrenal_gland1.04580297
77MP0002938_white_spotting1.03234329
78MP0009780_abnormal_chondrocyte_physiolo1.03183111
79MP0003950_abnormal_plasma_membrane1.02494095
80MP0005167_abnormal_blood-brain_barrier1.02237054
81MP0009697_abnormal_copulation1.00528729
82MP0001486_abnormal_startle_reflex1.00109929
83MP0002572_abnormal_emotion/affect_behav1.00048943
84MP0000026_abnormal_inner_ear0.99321507
85MP0005647_abnormal_sex_gland0.98829651
86MP0001756_abnormal_urination0.98819043
87MP0000372_irregular_coat_pigmentation0.96629306
88MP0000383_abnormal_hair_follicle0.96617522
89MP0005620_abnormal_muscle_contractility0.96520442
90MP0005195_abnormal_posterior_eye0.95817141
91MP0002133_abnormal_respiratory_system0.95519268
92MP0005388_respiratory_system_phenotype0.95519268
93MP0005408_hypopigmentation0.95435995
94MP0001542_abnormal_bone_strength0.95235238
95MP0004742_abnormal_vestibular_system0.94335472
96MP0005646_abnormal_pituitary_gland0.93951173
97MP0002067_abnormal_sensory_capabilities0.93948429
98MP0001502_abnormal_circadian_rhythm0.93419321
99MP0009763_increased_sensitivity_to0.91987644
100MP0000427_abnormal_hair_cycle0.91542693
101MP0000604_amyloidosis0.91158899
102MP0000013_abnormal_adipose_tissue0.90407153
103MP0008877_abnormal_DNA_methylation0.90223328
104MP0004084_abnormal_cardiac_muscle0.89923385
105MP0002735_abnormal_chemical_nociception0.89048843
106MP0003656_abnormal_erythrocyte_physiolo0.88314637
107MP0008469_abnormal_protein_level0.88087850
108MP0003119_abnormal_digestive_system0.86269808
109MP0005084_abnormal_gallbladder_morpholo0.86247236
110MP0002933_joint_inflammation0.86047446
111MP0004147_increased_porphyrin_level0.84355714
112MP0005410_abnormal_fertilization0.83816304
113MP0002136_abnormal_kidney_physiology0.83581555
114MP0005386_behavior/neurological_phenoty0.83388624
115MP0004924_abnormal_behavior0.83388624
116MP0009642_abnormal_blood_homeostasis0.83075474
117MP0002132_abnormal_respiratory_system0.81650795
118MP0008438_abnormal_cutaneous_collagen0.81194671
119MP0001879_abnormal_lymphatic_vessel0.81172265
120MP0004130_abnormal_muscle_cell0.80518466
121MP0002160_abnormal_reproductive_system0.79869491
122MP0003879_abnormal_hair_cell0.78999623
123MP0005670_abnormal_white_adipose0.78322694
124MP0006036_abnormal_mitochondrial_physio0.77653626
125MP0005376_homeostasis/metabolism_phenot0.76723730
126MP0002254_reproductive_system_inflammat0.73446565
127MP0009765_abnormal_xenobiotic_induced0.71103445
128MP0005058_abnormal_lysosome_morphology0.69342680
129MP0002876_abnormal_thyroid_physiology0.68116447
130MP0004043_abnormal_pH_regulation0.66816013
131MP0005220_abnormal_exocrine_pancreas0.65910321
132MP0002078_abnormal_glucose_homeostasis0.65306244
133MP0002971_abnormal_brown_adipose0.64894075
134MP0001765_abnormal_ion_homeostasis0.64330501
135MP0003075_altered_response_to0.62339785
136MP0001661_extended_life_span0.61440874
137MP0003329_amyloid_beta_deposits0.61389363
138MP0003690_abnormal_glial_cell0.60783104
139MP0003638_abnormal_response/metabolism_0.60495650
140MP0005535_abnormal_body_temperature0.60245343
141MP0005334_abnormal_fat_pad0.60240214
142MP0002168_other_aberrant_phenotype0.60197934
143MP0000249_abnormal_blood_vessel0.59504096
144MP0002295_abnormal_pulmonary_circulatio0.59320860
145MP0000230_abnormal_systemic_arterial0.53715398
146MP0005595_abnormal_vascular_smooth0.51938309
147MP0005395_other_phenotype0.51833400
148MP0005166_decreased_susceptibility_to0.51741705
149MP0005266_abnormal_metabolism0.51544399
150MP0005464_abnormal_platelet_physiology0.51127157
151MP0009053_abnormal_anal_canal0.50448488
152MP0005164_abnormal_response_to0.48220888
153MP0002796_impaired_skin_barrier0.46055923
154MP0002928_abnormal_bile_duct0.45493817
155MP0004883_abnormal_blood_vessel0.45319558
156MP0002837_dystrophic_cardiac_calcinosis0.44257950
157MP0005666_abnormal_adipose_tissue0.43781206
158MP0002135_abnormal_kidney_morphology0.43471693
159MP0009384_cardiac_valve_regurgitation0.43200766
160MP0000639_abnormal_adrenal_gland0.43141245
161MP0008874_decreased_physiological_sensi0.41690962
162MP0008873_increased_physiological_sensi0.40645073
163MP0005165_increased_susceptibility_to0.39166734
164MP0003300_gastrointestinal_ulcer0.38327932
165MP0005448_abnormal_energy_balance0.35144284
166MP0010234_abnormal_vibrissa_follicle0.33888340
167MP0003953_abnormal_hormone_level0.33548786
168MP0000343_altered_response_to0.33346184
169MP0001177_atelectasis0.32811882
170MP0005248_abnormal_Harderian_gland0.31902859
171MP0005275_abnormal_skin_tensile0.31777718
172MP0001845_abnormal_inflammatory_respons0.31444073
173MP0008995_early_reproductive_senescence0.31257213

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)7.10002720
2Abnormality of aromatic amino acid family metabolism (HP:0004338)6.75072690
3Intrahepatic cholestasis (HP:0001406)6.51694075
4Abnormality of monocarboxylic acid metabolism (HP:0010996)5.99456814
5Xanthomatosis (HP:0000991)5.74656758
6Prolonged partial thromboplastin time (HP:0003645)5.38386834
7Hypobetalipoproteinemia (HP:0003563)5.34018165
8Complement deficiency (HP:0004431)5.26560561
9Hyperlipoproteinemia (HP:0010980)4.84685487
10Abnormality of glutamine family amino acid metabolism (HP:0010902)4.42694590
11Hyperammonemia (HP:0001987)4.30669632
12Joint hemorrhage (HP:0005261)4.30161584
13Ketosis (HP:0001946)4.20202514
14Hyperglycinuria (HP:0003108)4.18365837
15Pancreatic cysts (HP:0001737)4.15765200
16Hyperglycinemia (HP:0002154)4.08550734
17Molar tooth sign on MRI (HP:0002419)4.08060188
18Abnormality of midbrain morphology (HP:0002418)4.08060188
19Hypolipoproteinemia (HP:0010981)3.99522967
20Epidermoid cyst (HP:0200040)3.98740100
21Abnormality of serine family amino acid metabolism (HP:0010894)3.97774552
22Abnormality of glycine metabolism (HP:0010895)3.97774552
23Abnormality of aspartate family amino acid metabolism (HP:0010899)3.97178561
24Abnormality of sulfur amino acid metabolism (HP:0004339)3.92323104
25Abnormality of complement system (HP:0005339)3.79177773
26Abnormality of the common coagulation pathway (HP:0010990)3.77545248
27Abnormality of methionine metabolism (HP:0010901)3.73714686
28Congenital stationary night blindness (HP:0007642)3.73598810
29Gout (HP:0001997)3.72016554
30Fat malabsorption (HP:0002630)3.70374940
31Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.68506938
32Nephronophthisis (HP:0000090)3.63495247
33Pancreatic fibrosis (HP:0100732)3.55632707
34Decreased circulating renin level (HP:0003351)3.54613314
35True hermaphroditism (HP:0010459)3.54559293
36Hypoalphalipoproteinemia (HP:0003233)3.52748223
37Hypoglycemic coma (HP:0001325)3.51689238
38Type II lissencephaly (HP:0007260)3.40726927
39Abnormality of the intrinsic pathway (HP:0010989)3.39026496
40Abnormality of fatty-acid metabolism (HP:0004359)3.33593772
41Abnormality of purine metabolism (HP:0004352)3.30450890
42Abnormality of nucleobase metabolism (HP:0010932)3.28358971
43Abnormality of the renal cortex (HP:0011035)3.27025141
44Large for gestational age (HP:0001520)3.24850010
45Ketoacidosis (HP:0001993)3.24749610
46Abnormality of pyrimidine metabolism (HP:0004353)3.24175135
47Hyperventilation (HP:0002883)3.23004015
48Abnormality of the renal medulla (HP:0100957)3.22731290
49Hypercholesterolemia (HP:0003124)3.18770917
50Keratoconus (HP:0000563)3.18581031
51Increased corneal curvature (HP:0100692)3.18581031
52Congenital, generalized hypertrichosis (HP:0004540)3.16540965
53Delayed CNS myelination (HP:0002188)3.13536808
54Tubular atrophy (HP:0000092)3.12913435
55Conjugated hyperbilirubinemia (HP:0002908)3.09371369
56Hypothermia (HP:0002045)3.08017697
57Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.05624125
58Vascular calcification (HP:0004934)3.00196743
59Hyperbilirubinemia (HP:0002904)2.94192048
60Polycythemia (HP:0001901)2.91850165
61Esophageal varix (HP:0002040)2.91656681
62Metabolic acidosis (HP:0001942)2.86904805
63Hepatocellular carcinoma (HP:0001402)2.83631720
64Steatorrhea (HP:0002570)2.82935179
65Systemic lupus erythematosus (HP:0002725)2.82667756
66Tubulointerstitial fibrosis (HP:0005576)2.80113871
67Thyroid-stimulating hormone excess (HP:0002925)2.77794182
68Abnormality of serum amino acid levels (HP:0003112)2.76042230
69Abolished electroretinogram (ERG) (HP:0000550)2.72106587
70Cardiovascular calcification (HP:0011915)2.70665987
71Chronic hepatic failure (HP:0100626)2.67836935
72Mitral stenosis (HP:0001718)2.65948059
73Recurrent gram-negative bacterial infections (HP:0005420)2.65531521
74Hyperactive renin-angiotensin system (HP:0000841)2.63030501
75Skin nodule (HP:0200036)2.61595177
76Cystic liver disease (HP:0006706)2.61568074
77Inability to walk (HP:0002540)2.60614890
78Alkalosis (HP:0001948)2.59663501
79Attenuation of retinal blood vessels (HP:0007843)2.59404269
80Myocardial infarction (HP:0001658)2.58482485
81Dicarboxylic aciduria (HP:0003215)2.54248096
82Abnormality of dicarboxylic acid metabolism (HP:0010995)2.54248096
83Spastic diplegia (HP:0001264)2.52343441
84Medial flaring of the eyebrow (HP:0010747)2.50627218
85Spontaneous abortion (HP:0005268)2.49539052
86Lethargy (HP:0001254)2.47276874
87Absent/shortened dynein arms (HP:0200106)2.47181951
88Dynein arm defect of respiratory motile cilia (HP:0012255)2.47181951
89Aplasia/Hypoplasia of the tibia (HP:0005772)2.47122892
90Hyperuricemia (HP:0002149)2.43272455
91Increased purine levels (HP:0004368)2.43272455
92Abnormal drinking behavior (HP:0030082)2.39733385
93Polydipsia (HP:0001959)2.39733385
94Hyperalaninemia (HP:0003348)2.39675171
95Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.39675171
96Abnormality of alanine metabolism (HP:0010916)2.39675171
97Cerebellar dysplasia (HP:0007033)2.39148287
98Amyloidosis (HP:0011034)2.38532775
99Generalized aminoaciduria (HP:0002909)2.34230344
100Hypochromic microcytic anemia (HP:0004840)2.32979240
101Congenital sensorineural hearing impairment (HP:0008527)2.32970592
102Abnormal ciliary motility (HP:0012262)2.32813266
103Mesangial abnormality (HP:0001966)2.32788702
104Pendular nystagmus (HP:0012043)2.32389439
105Malnutrition (HP:0004395)2.31984625
106Ulnar claw (HP:0001178)2.28665994
107Limb dystonia (HP:0002451)2.27916002
108Abnormality of proline metabolism (HP:0010907)2.27603940
109Hydroxyprolinuria (HP:0003080)2.27603940
110Neonatal onset (HP:0003623)2.25545725
111Glomerulonephritis (HP:0000099)2.25522638
112Irritability (HP:0000737)2.23044315
113Severe muscular hypotonia (HP:0006829)2.21846628
114Abnormal respiratory epithelium morphology (HP:0012253)2.20916437
115Abnormal respiratory motile cilium morphology (HP:0005938)2.20916437
116Proximal tubulopathy (HP:0000114)2.20864175
117Congenital hepatic fibrosis (HP:0002612)2.19011736
118Vomiting (HP:0002013)2.18844741
119Abnormal gallbladder morphology (HP:0012437)2.17363335
120Abnormal cartilage morphology (HP:0002763)2.16265708
121Sensorimotor neuropathy (HP:0007141)2.14928963
122Clumsiness (HP:0002312)2.14034087
123Cholelithiasis (HP:0001081)2.12778536
124Short hallux (HP:0010109)2.12477772
125Cerebral edema (HP:0002181)2.11110513
126Hypoglycemic seizures (HP:0002173)2.10298260
127Progressive inability to walk (HP:0002505)2.10287541
128Thrombophlebitis (HP:0004418)2.10061103
129Polyuria (HP:0000103)2.10018701
130Tubulointerstitial abnormality (HP:0001969)2.09849709
131Sclerocornea (HP:0000647)2.08719895
132Enlarged kidneys (HP:0000105)2.08690940
133Spontaneous hematomas (HP:0007420)2.08132464
134Furrowed tongue (HP:0000221)2.07718173
135Prolonged QT interval (HP:0001657)2.07470108
136Progressive cerebellar ataxia (HP:0002073)2.07069453
137Aplasia/Hypoplasia of the hallux (HP:0008362)2.06695714
138Abnormal rod and cone electroretinograms (HP:0008323)2.06303192
139Rickets (HP:0002748)2.06226498
140Abnormality of the renal collecting system (HP:0004742)2.06105044
141Genetic anticipation (HP:0003743)2.04930188
142Abnormality of the pons (HP:0007361)2.04607319
143Cerebral hemorrhage (HP:0001342)2.02371247
144Late onset (HP:0003584)2.00505635
145Stage 5 chronic kidney disease (HP:0003774)1.99094844
146Chorioretinal atrophy (HP:0000533)1.98502413
147Conjunctival telangiectasia (HP:0000524)1.98112214
148Pancreatitis (HP:0001733)1.97782926
149Prominent supraorbital ridges (HP:0000336)1.96589785
150Abnormality of the gallbladder (HP:0005264)1.96178975
151Respiratory distress (HP:0002098)1.94608546
152Gaze-evoked nystagmus (HP:0000640)1.94290024
153Nephritis (HP:0000123)1.93673154
154Stomach cancer (HP:0012126)1.93512129
155Abnormality of renin-angiotensin system (HP:0000847)1.93369200
156Menorrhagia (HP:0000132)1.93166652
157Tachypnea (HP:0002789)1.93110471
158Genital tract atresia (HP:0001827)1.93011059
159Vaginal atresia (HP:0000148)1.93003574
160Lissencephaly (HP:0001339)1.92826558
161Hemorrhage of the eye (HP:0011885)1.92755756
162Abnormal enzyme/coenzyme activity (HP:0012379)1.92508365
163Duplicated collecting system (HP:0000081)1.92216155
164Gait imbalance (HP:0002141)1.92018297
165Calf muscle hypertrophy (HP:0008981)1.91768738
166Broad-based gait (HP:0002136)1.90999169
167Acanthocytosis (HP:0001927)1.90933977
168Nephrolithiasis (HP:0000787)1.89818364
169Renal cortical cysts (HP:0000803)1.89323011
170Facial shape deformation (HP:0011334)1.88968966
171Potter facies (HP:0002009)1.88968966
172Short tibia (HP:0005736)1.88819903
173Male pseudohermaphroditism (HP:0000037)1.88278301
174Interstitial pulmonary disease (HP:0006530)1.88171205
175Stroke (HP:0001297)1.86767298
176Decreased electroretinogram (ERG) amplitude (HP:0000654)1.84305911
177Hypoplasia of the pons (HP:0012110)1.84042422
178Bile duct proliferation (HP:0001408)1.83652772
179Abnormal biliary tract physiology (HP:0012439)1.83652772
180Abnormal urine output (HP:0012590)1.82144286
181Conical tooth (HP:0000698)1.81656416
182Decreased central vision (HP:0007663)1.80779974
183Muscle hypertrophy of the lower extremities (HP:0008968)1.79314601
184Concave nail (HP:0001598)1.79258732
185Exertional dyspnea (HP:0002875)1.78641843
186Abnormal respiratory motile cilium physiology (HP:0012261)1.78122439
187Anencephaly (HP:0002323)1.77871559
188Hemiparesis (HP:0001269)1.75445516
189Pachygyria (HP:0001302)1.74706648
190Aplasia/Hypoplasia of the patella (HP:0006498)1.73931142
191Congenital primary aphakia (HP:0007707)1.73861523
192Protruding tongue (HP:0010808)1.73243195
193Polyphagia (HP:0002591)1.72521475
194Broad metatarsal (HP:0001783)1.72090343

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK5.67149323
2TIE14.64444344
3FGFR44.18965717
4ERN13.80906426
5ADRBK23.59455515
6SIK13.41754912
7BMPR1B3.10463124
8TLK12.88310567
9TGFBR22.75106843
10ACVR1B2.68747175
11ZAK2.46588016
12TRIB32.31172445
13TAOK32.09377340
14MST1R2.06650300
15INSRR2.03122305
16ERBB41.89118601
17MAP4K21.87037790
18PKN21.86838232
19MAPK131.75033442
20MUSK1.68590191
21FGFR21.68031823
22PTK61.60746237
23ADRBK11.58726062
24CASK1.58647536
25DAPK21.57431019
26KDR1.54748787
27MAP2K41.54040763
28MAP3K41.53804167
29TYK21.48709560
30EPHB11.45645430
31GRK11.42854560
32MARK11.39801817
33PNCK1.37743530
34LATS11.37355006
35OBSCN1.36295464
36MAPK111.35531784
37MYLK1.33094596
38PHKG21.32235667
39PHKG11.32235667
40MAP3K31.32143951
41NUAK11.29255813
42NEK91.28202623
43MAP2K31.28202147
44CSK1.26426595
45MAPKAPK31.22727710
46ABL21.22510144
47WNK41.22343627
48RIPK11.21627054
49EPHB21.17710094
50FLT31.16971687
51STK38L1.16265699
52LRRK21.14971787
53PRKCE1.14053189
54PIK3CG1.13248297
55TNIK1.11850745
56MAP3K71.11661065
57JAK21.08548055
58CAMKK21.05988567
59FRK1.05094769
60DYRK21.04879390
61PRKCG1.02679542
62JAK11.00990766
63STK391.00980751
64MAPK150.97443816
65PINK10.95710170
66MET0.94678129
67GRK60.94404903
68TBK10.93943149
69NLK0.93472840
70WNK30.92494411
71PIK3CA0.92305240
72RPS6KA50.91801228
73NTRK30.89496511
74PRKAA20.88891583
75GSK3A0.87702284
76GRK70.87228582
77VRK10.86109102
78OXSR10.82924379
79MAPKAPK50.81859661
80EPHA30.81025972
81TXK0.79663464
82TRPM70.79660561
83FGFR30.79606015
84FER0.79571699
85MAP2K70.79150949
86MAPK40.77072074
87PDPK10.76480566
88CAMK1D0.76351420
89PRKCZ0.76178788
90PDK30.74606451
91PDK40.74606451
92PDGFRA0.73153036
93PTK20.71408494
94CAMK2A0.70105489
95TGFBR10.68895333
96ERBB20.68477104
97MAPK120.65953855
98SGK30.65188211
99MAP3K140.64658829
100PKN10.63483773
101GRK50.61382242
102PRKACA0.60544663
103MAP2K20.60361745
104STK100.60117630
105PRKACG0.59785036
106MAP3K20.58140638
107MAP3K110.56990520
108SGK2230.56938398
109SGK4940.56938398
110NTRK20.55181616
111CDK60.55019588
112ZAP700.55006548
113CAMK2G0.54197009
114MKNK20.53207792
115IRAK10.52988360
116DYRK1B0.51543937
117EGFR0.50807971
118RPS6KA60.49587360
119PRKG10.49155654
120CHUK0.47314611
121PRKCQ0.47115829
122IKBKE0.46859518
123MAP2K60.46564338
124CSNK1G20.45326980
125IGF1R0.45248949
126CSNK1G10.45205557
127PTK2B0.45131202
128PDK20.44687194
129MAP2K10.44467007
130BRSK20.42918103
131CSF1R0.42873257
132CAMK10.42752080
133PRKCA0.42727826
134PRKAA10.42483681
135RET0.42318863
136PRKCH0.41289012
137IKBKB0.40593724
138PRKD10.40485899
139SGK20.39904504
140PAK40.39081404
141STK30.38776770
142PRKCI0.37576889
143STK110.36831127
144KIT0.36748384
145PDK10.34629828
146KSR20.33277103
147PRKACB0.32951842
148ROCK10.32699511
149PAK30.32363461
150WNK10.31524526
151TEC0.31271308
152AKT30.30322765
153MAP3K100.29322011
154CAMK1G0.28679259
155TTN0.28595518
156IRAK30.27729866
157ABL10.26900487
158CSNK1G30.26351827
159CAMK40.25492721

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.26663801
2Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.50137901
3Nitrogen metabolism_Homo sapiens_hsa009103.35410272
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.19493220
5Arginine biosynthesis_Homo sapiens_hsa002202.83519550
6* Tryptophan metabolism_Homo sapiens_hsa003802.70590157
7Complement and coagulation cascades_Homo sapiens_hsa046102.61732039
8Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.59314498
9Fatty acid degradation_Homo sapiens_hsa000712.59197440
10Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.59175199
11Phototransduction_Homo sapiens_hsa047442.54290566
12Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.53725370
13Pentose and glucuronate interconversions_Homo sapiens_hsa000402.43261389
14Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.42319024
15Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.39424774
16Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.35150135
17Butanoate metabolism_Homo sapiens_hsa006502.31339484
18Peroxisome_Homo sapiens_hsa041462.17447041
19Propanoate metabolism_Homo sapiens_hsa006402.08963947
20Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.08588442
21Caffeine metabolism_Homo sapiens_hsa002322.05942046
22Chemical carcinogenesis_Homo sapiens_hsa052042.05044985
23Histidine metabolism_Homo sapiens_hsa003402.00724089
24PPAR signaling pathway_Homo sapiens_hsa033201.88849478
25Steroid hormone biosynthesis_Homo sapiens_hsa001401.85259317
26Fatty acid metabolism_Homo sapiens_hsa012121.84553739
27beta-Alanine metabolism_Homo sapiens_hsa004101.81775311
28Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.80416108
29Ether lipid metabolism_Homo sapiens_hsa005651.78096128
30Retinol metabolism_Homo sapiens_hsa008301.76531311
31Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.74763836
32Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.74491752
33Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.73162270
34Oxidative phosphorylation_Homo sapiens_hsa001901.72654925
35Nicotine addiction_Homo sapiens_hsa050331.68184029
36Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.67587373
37Drug metabolism - other enzymes_Homo sapiens_hsa009831.63997050
38Staphylococcus aureus infection_Homo sapiens_hsa051501.61811993
39Phenylalanine metabolism_Homo sapiens_hsa003601.58524609
40Bile secretion_Homo sapiens_hsa049761.57711582
41Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.56043030
42Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.55585044
432-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.54654246
44Pyruvate metabolism_Homo sapiens_hsa006201.48389010
45Sulfur metabolism_Homo sapiens_hsa009201.44930185
46Cardiac muscle contraction_Homo sapiens_hsa042601.41031987
47Tyrosine metabolism_Homo sapiens_hsa003501.34124281
48Parkinsons disease_Homo sapiens_hsa050121.32372945
49Fatty acid elongation_Homo sapiens_hsa000621.30476658
50Vascular smooth muscle contraction_Homo sapiens_hsa042701.29599702
51Starch and sucrose metabolism_Homo sapiens_hsa005001.26283202
52Morphine addiction_Homo sapiens_hsa050321.24533544
53* Selenocompound metabolism_Homo sapiens_hsa004501.24322732
54Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.19553316
55Taste transduction_Homo sapiens_hsa047421.17778941
56Cysteine and methionine metabolism_Homo sapiens_hsa002701.17236446
57Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.17216215
58Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.16047130
59Carbon metabolism_Homo sapiens_hsa012001.13462424
60Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.11686699
61ABC transporters_Homo sapiens_hsa020101.11156683
62Intestinal immune network for IgA production_Homo sapiens_hsa046721.10692246
63Serotonergic synapse_Homo sapiens_hsa047261.10566833
64Cyanoamino acid metabolism_Homo sapiens_hsa004601.08763810
65Biosynthesis of amino acids_Homo sapiens_hsa012301.07337873
66ECM-receptor interaction_Homo sapiens_hsa045121.07335701
67Folate biosynthesis_Homo sapiens_hsa007901.06286220
68Arginine and proline metabolism_Homo sapiens_hsa003301.01542747
69Steroid biosynthesis_Homo sapiens_hsa001001.01217022
70Circadian entrainment_Homo sapiens_hsa047130.98937314
71Insulin secretion_Homo sapiens_hsa049110.98440031
72Olfactory transduction_Homo sapiens_hsa047400.97555843
73Fat digestion and absorption_Homo sapiens_hsa049750.96579509
74Vitamin digestion and absorption_Homo sapiens_hsa049770.96000971
75GABAergic synapse_Homo sapiens_hsa047270.91848799
76Glutamatergic synapse_Homo sapiens_hsa047240.91445968
77Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.91443335
78Glutathione metabolism_Homo sapiens_hsa004800.87850408
79Calcium signaling pathway_Homo sapiens_hsa040200.87208749
80Systemic lupus erythematosus_Homo sapiens_hsa053220.86742509
81Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.85074619
82Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.84706553
83Sulfur relay system_Homo sapiens_hsa041220.84491117
84Alzheimers disease_Homo sapiens_hsa050100.84016963
85Maturity onset diabetes of the young_Homo sapiens_hsa049500.83050595
86Dilated cardiomyopathy_Homo sapiens_hsa054140.82515691
87Protein export_Homo sapiens_hsa030600.81912818
88Cocaine addiction_Homo sapiens_hsa050300.80289014
89Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.79719261
90Lysine degradation_Homo sapiens_hsa003100.78763919
91Dorso-ventral axis formation_Homo sapiens_hsa043200.77705961
92Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.75121601
93Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.75072519
94Asthma_Homo sapiens_hsa053100.73999830
95Huntingtons disease_Homo sapiens_hsa050160.72283209
96Glycerolipid metabolism_Homo sapiens_hsa005610.71400240
97Salivary secretion_Homo sapiens_hsa049700.70159182
98Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.69659922
99Renin secretion_Homo sapiens_hsa049240.68775827
100Circadian rhythm_Homo sapiens_hsa047100.65870694
101Vitamin B6 metabolism_Homo sapiens_hsa007500.63555966
102Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.63443390
103Aldosterone synthesis and secretion_Homo sapiens_hsa049250.59704711
104Pentose phosphate pathway_Homo sapiens_hsa000300.56240063
105Hedgehog signaling pathway_Homo sapiens_hsa043400.53955859
106Basal cell carcinoma_Homo sapiens_hsa052170.53830255
107Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.53528133
108Oxytocin signaling pathway_Homo sapiens_hsa049210.51766302
109Dopaminergic synapse_Homo sapiens_hsa047280.49820774
110Fatty acid biosynthesis_Homo sapiens_hsa000610.49761737
111Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.48645454
112Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.48340386
113Basal transcription factors_Homo sapiens_hsa030220.47861404
114Gastric acid secretion_Homo sapiens_hsa049710.46594977
115cAMP signaling pathway_Homo sapiens_hsa040240.46093578
116Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.46029803
117Cholinergic synapse_Homo sapiens_hsa047250.42620433
118Amphetamine addiction_Homo sapiens_hsa050310.41967493
119Metabolic pathways_Homo sapiens_hsa011000.41960438
120One carbon pool by folate_Homo sapiens_hsa006700.41758134
121cGMP-PKG signaling pathway_Homo sapiens_hsa040220.40460106
122Prion diseases_Homo sapiens_hsa050200.37129625
123Adipocytokine signaling pathway_Homo sapiens_hsa049200.27483597
124Insulin resistance_Homo sapiens_hsa049310.25612462
125Fructose and mannose metabolism_Homo sapiens_hsa000510.24558733
126Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.22034846
127Galactose metabolism_Homo sapiens_hsa000520.15582519
128alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.13002034
129Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.09332272
130Glycerophospholipid metabolism_Homo sapiens_hsa005640.08438614
131Linoleic acid metabolism_Homo sapiens_hsa005910.06629343
132Renin-angiotensin system_Homo sapiens_hsa046140.06079723
133Glucagon signaling pathway_Homo sapiens_hsa049220.04019182
134AMPK signaling pathway_Homo sapiens_hsa041520.02965187
135Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.01436844
136Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.1755852
137Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.1739635
138Regulation of autophagy_Homo sapiens_hsa04140-0.1715934
139Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.1678692
140Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534-0.1666377
141African trypanosomiasis_Homo sapiens_hsa05143-0.1625024
142Bladder cancer_Homo sapiens_hsa05219-0.1591574
143Amoebiasis_Homo sapiens_hsa05146-0.1279902
144Insulin signaling pathway_Homo sapiens_hsa04910-0.1198067
145Protein digestion and absorption_Homo sapiens_hsa04974-0.1086677
146Pertussis_Homo sapiens_hsa05133-0.1072389
147Hepatitis C_Homo sapiens_hsa05160-0.1049003
148Arachidonic acid metabolism_Homo sapiens_hsa00590-0.0955152
149Thyroid hormone synthesis_Homo sapiens_hsa04918-0.0700682
150Mineral absorption_Homo sapiens_hsa04978-0.0697874
151Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932-0.0608293
152Lysosome_Homo sapiens_hsa04142-0.0461126
153Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.0152769
154Ovarian steroidogenesis_Homo sapiens_hsa04913-0.0093138

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