INO80

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a subunit of the chromatin remodeling complex, which is classified into subfamilies depending on sequence features apart from the conserved ATPase domain. This protein is the catalytic ATPase subunit of the INO80 chromatin remodeling complex, which is characterized by a DNA-binding domain. This protein is proposed to bind DNA and be recruited by the YY1 transcription factor to activate certain genes. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1polyketide metabolic process (GO:0030638)9.15625951
2doxorubicin metabolic process (GO:0044598)9.15625951
3daunorubicin metabolic process (GO:0044597)9.15625951
4protein localization to kinetochore (GO:0034501)6.56764353
5maintenance of protein location in nucleus (GO:0051457)6.04406064
6negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)5.94879615
7nuclear pore complex assembly (GO:0051292)5.84655020
8aminoglycoside antibiotic metabolic process (GO:0030647)5.77023660
9regulation of telomere maintenance via telomerase (GO:0032210)5.66658738
10regulation of mammary gland epithelial cell proliferation (GO:0033599)5.59636420
11histone H4-K12 acetylation (GO:0043983)5.54501081
12somite rostral/caudal axis specification (GO:0032525)5.49328520
13negative regulation of cell cycle G2/M phase transition (GO:1902750)5.41450829
14histone H4-K5 acetylation (GO:0043981)5.39905774
15histone H4-K8 acetylation (GO:0043982)5.39905774
16negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)5.24838356
17regulation of response to osmotic stress (GO:0047484)5.23113758
18negative regulation of epidermis development (GO:0045683)5.16239308
19negative regulation of telomerase activity (GO:0051974)5.15009115
20nuclear pore organization (GO:0006999)5.09853836
21heterochromatin organization (GO:0070828)4.94076633
22muscle organ morphogenesis (GO:0048644)4.93933588
23regulation of MHC class I biosynthetic process (GO:0045343)4.93460671
24protein localization to chromosome, centromeric region (GO:0071459)4.90830487
25rRNA transcription (GO:0009303)4.71616769
26chromatin assembly (GO:0031497)4.54116549
27pore complex assembly (GO:0046931)4.46529240
28notochord development (GO:0030903)4.40470282
29interferon-gamma production (GO:0032609)4.37862404
30histone H4-K16 acetylation (GO:0043984)4.25054010
31DNA replication-dependent nucleosome assembly (GO:0006335)4.20999481
32DNA replication-dependent nucleosome organization (GO:0034723)4.20999481
33regulation of translation in response to stress (GO:0043555)4.19797987
34pre-miRNA processing (GO:0031054)4.12877414
35regulation of RNA export from nucleus (GO:0046831)4.08316543
36histone H3-K36 demethylation (GO:0070544)4.06717452
37cytidine catabolic process (GO:0006216)4.05749035
38cytidine deamination (GO:0009972)4.05749035
39cytidine metabolic process (GO:0046087)4.05749035
40negative regulation of telomere maintenance (GO:0032205)4.05535131
41DNA replication checkpoint (GO:0000076)4.00367960
42negative regulation of epidermal cell differentiation (GO:0045605)3.96987124
43hormone catabolic process (GO:0042447)3.89379035
44branching involved in mammary gland duct morphogenesis (GO:0060444)3.85660813
45rRNA methylation (GO:0031167)3.85505636
46RNA stabilization (GO:0043489)3.84131194
47mRNA stabilization (GO:0048255)3.84131194
48positive regulation of protein deacetylation (GO:0090312)3.80799750
49primitive streak formation (GO:0090009)3.74145598
50intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator (GO:0042771)3.71601750
51regulation of telomere maintenance (GO:0032204)3.67551236
52regulation of nucleobase-containing compound transport (GO:0032239)3.64715877
53positive regulation of histone deacetylation (GO:0031065)3.62619962
54mitotic sister chromatid cohesion (GO:0007064)3.61811046
55cell fate commitment involved in formation of primary germ layer (GO:0060795)3.60729835
56regulation of apoptotic process involved in morphogenesis (GO:1902337)3.59204044
57mitotic chromosome condensation (GO:0007076)3.51076624
58trophectodermal cell differentiation (GO:0001829)3.50350076
59NLS-bearing protein import into nucleus (GO:0006607)3.49473056
60regulation of cilium movement (GO:0003352)3.48650324
61regulation of posttranscriptional gene silencing (GO:0060147)3.47544979
62regulation of gene silencing by miRNA (GO:0060964)3.47544979
63regulation of gene silencing by RNA (GO:0060966)3.47544979
64rRNA modification (GO:0000154)3.46621711
65nucleoside transmembrane transport (GO:1901642)3.42029437
66intestinal epithelial cell development (GO:0060576)3.41336711
67regulation of intracellular estrogen receptor signaling pathway (GO:0033146)3.40650456
68negative regulation of histone methylation (GO:0031061)3.40300426
69phenol-containing compound catabolic process (GO:0019336)3.34593992
70maintenance of protein localization in organelle (GO:0072595)3.34417499
71* mitotic sister chromatid segregation (GO:0000070)3.34340058
72embryonic process involved in female pregnancy (GO:0060136)3.34086133
73response to UV-C (GO:0010225)3.31440650
74histone H3-K9 demethylation (GO:0033169)3.29573010
75negative regulation of erythrocyte differentiation (GO:0045647)3.29359352
76regulation of histone H3-K27 methylation (GO:0061085)3.27959734
77histone H3-K4 methylation (GO:0051568)3.22336157
78mitochondrion distribution (GO:0048311)3.21938963
79negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.21561188
80retinoic acid receptor signaling pathway (GO:0048384)3.15443884
81response to dietary excess (GO:0002021)3.10825619
82ribosome biogenesis (GO:0042254)3.08846834
83regulation of double-strand break repair (GO:2000779)3.08578860
84coenzyme catabolic process (GO:0009109)3.08174946
85regulation of odontogenesis of dentin-containing tooth (GO:0042487)3.07227717
86DNA unwinding involved in DNA replication (GO:0006268)3.04401944
87* DNA duplex unwinding (GO:0032508)3.04186151
88spliceosomal tri-snRNP complex assembly (GO:0000244)3.03804662
89* DNA geometric change (GO:0032392)3.01249572
90quinone metabolic process (GO:1901661)3.00395346
91intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress (GO:0070059)3.00002761
92histone lysine demethylation (GO:0070076)2.99638294
93* sister chromatid segregation (GO:0000819)2.97633814
94maternal placenta development (GO:0001893)2.97603383
95establishment of endothelial barrier (GO:0061028)2.95505666
96regulation of telomerase activity (GO:0051972)2.95138389
97histone demethylation (GO:0016577)2.94208525
98hypotonic response (GO:0006971)2.92440611
99regulation of NFAT protein import into nucleus (GO:0051532)2.91527317
100pinocytosis (GO:0006907)2.88705305
101intracellular estrogen receptor signaling pathway (GO:0030520)2.88508705
102positive regulation of transcription initiation from RNA polymerase II promoter (GO:0060261)2.88052411
103pyrimidine ribonucleoside catabolic process (GO:0046133)2.87761867
104response to laminar fluid shear stress (GO:0034616)2.87475620
105regulation of hippo signaling (GO:0035330)2.87192840
106histone H3-K4 trimethylation (GO:0080182)2.87183872
107vitamin A metabolic process (GO:0006776)2.85634157
108positive regulation of DNA-templated transcription, initiation (GO:2000144)2.85586826
109positive regulation of gamma-delta T cell activation (GO:0046645)2.85459516
110cardiovascular system development (GO:0072358)2.84832625
111bone trabecula formation (GO:0060346)2.84703997
112apoptotic DNA fragmentation (GO:0006309)2.83065384
113negative regulation of gene silencing (GO:0060969)2.82579634
114regulation of necroptotic process (GO:0060544)2.82515831
115cytoplasmic mRNA processing body assembly (GO:0033962)2.80205282
116positive regulation of defense response to virus by host (GO:0002230)2.77694010
117cellular modified amino acid catabolic process (GO:0042219)2.75654813
118positive regulation of protein import into nucleus, translocation (GO:0033160)2.75533404
119protein localization to endosome (GO:0036010)2.75207728
120formation of translation preinitiation complex (GO:0001731)2.75152429
121epoxygenase P450 pathway (GO:0019373)2.73627793
122mitotic nuclear envelope disassembly (GO:0007077)2.71925200
123* regulation of nuclear cell cycle DNA replication (GO:0033262)2.71356148
124regulation of histone H3-K9 methylation (GO:0051570)2.69526374
125cell-substrate adherens junction assembly (GO:0007045)2.69116157
126focal adhesion assembly (GO:0048041)2.69116157
127regulation of interferon-beta biosynthetic process (GO:0045357)2.68097413
128negative regulation of necroptotic process (GO:0060546)2.68042176
129positive regulation of transcription from RNA polymerase III promoter (GO:0045945)2.64126705
130regulation of histone methylation (GO:0031060)2.63696950
131negative regulation of DNA repair (GO:0045738)2.58710410
132protein dealkylation (GO:0008214)2.58542645
133protein demethylation (GO:0006482)2.58542645
134positive regulation of Cdc42 GTPase activity (GO:0043089)2.57283679
135regulation of type I interferon-mediated signaling pathway (GO:0060338)2.56935058
136regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00432.54744560
137modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.49638258
138positive regulation by organism of defense response of other organism involved in symbiotic interact2.49638258
139modulation by symbiont of host immune response (GO:0052553)2.49638258
140positive regulation by symbiont of host defense response (GO:0052509)2.49638258
141modulation by symbiont of host defense response (GO:0052031)2.49638258
142modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.49638258
143regulation of histone H3-K4 methylation (GO:0051569)2.48270427
144stress fiber assembly (GO:0043149)2.47000724
145mannose metabolic process (GO:0006013)2.46577345
146macrophage activation involved in immune response (GO:0002281)2.46054403
147positive regulation of protein export from nucleus (GO:0046827)2.45022104
148negative regulation of histone modification (GO:0031057)2.44163752
149protein ubiquitination involved in ubiquitin-dependent protein catabolic process (GO:0042787)2.44159926
150cell-substrate junction assembly (GO:0007044)2.43562115
151peptidyl-threonine modification (GO:0018210)2.43525534
152positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.43491354
153protein localization to microtubule (GO:0035372)2.41081888
154peptidyl-threonine phosphorylation (GO:0018107)2.40239216
155adherens junction assembly (GO:0034333)2.39988243
156modulation by symbiont of host cellular process (GO:0044068)2.38946644
157skin morphogenesis (GO:0043589)2.36531260
158positive regulation of keratinocyte differentiation (GO:0045618)2.34216916
159peptidyl-lysine trimethylation (GO:0018023)2.31844653
160response to peptidoglycan (GO:0032494)2.28918222
161positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.28253763
162cellular hyperosmotic response (GO:0071474)2.27257259
163modulation by virus of host process (GO:0019054)2.26021243
164monoubiquitinated protein deubiquitination (GO:0035520)2.25319656
165regulation of gamma-delta T cell activation (GO:0046643)2.25012525
1663-UTR-mediated mRNA stabilization (GO:0070935)2.22559820
167phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.22488017
168germinal center formation (GO:0002467)2.22435508
169response to muramyl dipeptide (GO:0032495)2.22075148
170insulin-like growth factor receptor signaling pathway (GO:0048009)2.21968680
171peptidyl-lysine dimethylation (GO:0018027)2.20682811
172regulation of gamma-delta T cell differentiation (GO:0045586)2.20680418
173B cell receptor signaling pathway (GO:0050853)2.19840549
174positive regulation of interferon-alpha production (GO:0032727)2.19153580
175N-terminal protein amino acid acetylation (GO:0006474)2.18072797
176mammary gland epithelial cell proliferation (GO:0033598)2.16916763
177protein export from nucleus (GO:0006611)2.16914512
178histone lysine methylation (GO:0034968)2.15869872
179cellular response to ethanol (GO:0071361)2.14687824
180peptidyl-lysine methylation (GO:0018022)2.14469564
181dosage compensation (GO:0007549)2.13725170
182hepatocyte apoptotic process (GO:0097284)2.13678917
183negative regulation of chromatin modification (GO:1903309)2.11903304
184antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.11819668
185glucocorticoid receptor signaling pathway (GO:0042921)2.11772470
186mRNA transcription (GO:0009299)2.09540635

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.19805649
2BP1_19119308_ChIP-ChIP_Hs578T_Human5.99515229
3KLF2_18264089_ChIP-ChIP_MESCs_Mouse5.94863585
4KLF5_18264089_ChIP-ChIP_MESCs_Mouse5.94863585
5KLF4_18264089_ChIP-ChIP_MESCs_Mouse5.94863585
6TP63_19390658_ChIP-ChIP_HaCaT_Human3.35828721
7FOXM1_23109430_ChIP-Seq_U2OS_Human3.07508838
8NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.05476387
9TP63_17297297_ChIP-ChIP_HaCaT_Human3.03721234
10NACC1_18358816_ChIP-ChIP_MESCs_Mouse3.00300500
11E2F4_17652178_ChIP-ChIP_JURKAT_Human2.89351292
12SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.85577319
13POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.67254025
14SOX2_18358816_ChIP-ChIP_MESCs_Mouse2.58950372
15SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.53053605
16MYB_21317192_ChIP-Seq_ERMYB_Mouse2.49199879
17TCF3_18692474_ChIP-Seq_MESCs_Mouse2.37569787
18TCF3_18692474_ChIP-Seq_MEFs_Mouse2.24850141
19FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.22201212
20NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.21474113
21FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.08791124
22GATA1_22025678_ChIP-Seq_K562_Human2.07177498
23KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human2.06782244
24STAT6_21828071_ChIP-Seq_BEAS2B_Human2.05941368
25MYC_22102868_ChIP-Seq_BL_Human2.03953935
26* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.03860340
27EGR1_19374776_ChIP-ChIP_THP-1_Human1.91835395
28STAT3_1855785_ChIP-Seq_MESCs_Mouse1.87367399
29* STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.87144484
30NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.85717255
31NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.85379344
32MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.83568780
33ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.82909773
34VDR_24763502_ChIP-Seq_THP-1_Human1.82816110
35IRF8_22096565_ChIP-ChIP_GC-B_Human1.81916747
36BRD4_27068464_Chip-Seq_AML-cells_Mouse1.78462130
37* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.77214374
38ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.76412990
39MAF_26560356_Chip-Seq_TH1_Human1.74201440
40STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.73031931
41ZNF263_19887448_ChIP-Seq_K562_Human1.71792217
42HIF1A_21447827_ChIP-Seq_MCF-7_Human1.71510788
43* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.70592654
44Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.65912914
45MYC_18555785_ChIP-Seq_MESCs_Mouse1.64987810
46RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.63306399
47SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.62851294
48SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.62413430
49SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.62413430
50SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.62215314
51KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.61161918
52NANOG_18555785_ChIP-Seq_MESCs_Mouse1.59908960
53NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.59252268
54POU5F1_16518401_ChIP-PET_MESCs_Mouse1.58989094
55VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.57398790
56MYC_19079543_ChIP-ChIP_MESCs_Mouse1.56919166
57NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.53160812
58* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.53146455
59ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.52846511
60BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.49769394
61TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.49201011
62POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.48211831
63TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.47353627
64FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.46191769
65* RUNX1_22412390_ChIP-Seq_EML_Mouse1.45738759
66ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.42654949
67CLOCK_20551151_ChIP-Seq_293T_Human1.42624840
68MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.41789834
69P300_27058665_Chip-Seq_ZR-75-30cells_Human1.39769762
70TCF7_22412390_ChIP-Seq_EML_Mouse1.38678764
71IRF8_27001747_Chip-Seq_BMDM_Mouse1.38521224
72ESR1_20079471_ChIP-ChIP_T-47D_Human1.38217420
73NANOG_18692474_ChIP-Seq_MESCs_Mouse1.37935229
74CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.37923047
75SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.36898078
76MYC_19030024_ChIP-ChIP_MESCs_Mouse1.36821499
77IRF1_19129219_ChIP-ChIP_H3396_Human1.36089682
78TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.35368794
79TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.34464699
80NOTCH1_21737748_ChIP-Seq_TLL_Human1.33905831
81ZFP281_27345836_Chip-Seq_ESCs_Mouse1.32885262
82RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.31808384
83PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.30378006
84* MYB_26560356_Chip-Seq_TH2_Human1.29450708
85NANOG_18692474_ChIP-Seq_MEFs_Mouse1.28064432
86SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.28050168
87FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.27638487
88TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.27345635
89TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.27185240
90SOX2_18555785_ChIP-Seq_MESCs_Mouse1.26462125
91STAT4_19710469_ChIP-ChIP_TH1__Mouse1.26242587
92POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.26176278
93CHD1_26751641_Chip-Seq_LNCaP_Human1.25874365
94* UTX_26944678_Chip-Seq_JUKART_Human1.25767425
95* ATF3_27146783_Chip-Seq_COLON_Human1.25431507
96* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.23996707
97CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.23838893
98POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.23732098
99DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.22220438
100UBF1/2_26484160_Chip-Seq_HMECs_Human1.21561891
101KDM2B_26808549_Chip-Seq_JURKAT_Human1.21412736
102* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.21399546
103MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.20781042
104SPI1_23547873_ChIP-Seq_NB4_Human1.20659750
105MAF_26560356_Chip-Seq_TH2_Human1.19923510
106ESR2_21235772_ChIP-Seq_MCF-7_Human1.19816256
107SPI1_23127762_ChIP-Seq_K562_Human1.18680375
108SCL_19346495_ChIP-Seq_HPC-7_Human1.17208069
109STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.17002263
110TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.16206095
111SOX2_18692474_ChIP-Seq_MESCs_Mouse1.15976533
112CDX2_20551321_ChIP-Seq_CACO-2_Human1.14561804
113* NCOR1_26117541_ChIP-Seq_K562_Human1.14310010
114NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.13998526
115ZFP281_18757296_ChIP-ChIP_E14_Mouse1.13778364
116NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.12884175
117TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.12360005
118SOX2_27498859_Chip-Seq_STOMACH_Mouse1.12036011
119NANOG_16518401_ChIP-PET_MESCs_Mouse1.11995157
120SOX9_24532713_ChIP-Seq_HFSC_Mouse1.11085124
121CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.10172649
122NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.09771237
123OCT4_18692474_ChIP-Seq_MEFs_Mouse1.08617910
124SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.08132901
125EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.08121635
126NANOG_21062744_ChIP-ChIP_HESCs_Human1.06631387
127PU_27001747_Chip-Seq_BMDM_Mouse1.05915564
128PPAR_26484153_Chip-Seq_NCI-H1993_Human1.05901569
129PKCTHETA_26484144_Chip-Seq_BREAST_Human1.05721919
130GATA1_22383799_ChIP-Seq_G1ME_Mouse1.05444965
131E2F1_17053090_ChIP-ChIP_MCF-7_Human1.04919214
132TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.04776555
133* GATA6_25053715_ChIP-Seq_YYC3_Human1.03732451
134* RUNX1_27514584_Chip-Seq_MCF-7_Human1.03038034
135KDM2B_26808549_Chip-Seq_SUP-B15_Human1.02672350
136KDM2B_26808549_Chip-Seq_K562_Human1.02418403
137IRF8_21731497_ChIP-ChIP_J774_Mouse1.02119048
138* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.02113154
139RUNX_20019798_ChIP-Seq_JUKART_Human1.01983562
140GATA2_22383799_ChIP-Seq_G1ME_Mouse1.01755194
141KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.00249263
142TP53_22127205_ChIP-Seq_IMR90_Human0.97576272
143MYC_18358816_ChIP-ChIP_MESCs_Mouse0.95420296
144SOX2_18692474_ChIP-Seq_MEFs_Mouse0.95133677
145YY1_21170310_ChIP-Seq_MESCs_Mouse0.92993386
146PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.90689661
147POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.89635581
148KLF4_18555785_ChIP-Seq_MESCs_Mouse0.88775101
149AR_21909140_ChIP-Seq_LNCAP_Human0.88618128
150ELK3_25401928_ChIP-Seq_HUVEC_Human0.88457134
151FOXO3_23340844_ChIP-Seq_DLD1_Human0.88151171
152KDM5A_27292631_Chip-Seq_BREAST_Human0.88057336
153NANOG_16153702_ChIP-ChIP_HESCs_Human0.87906918
154SALL1_21062744_ChIP-ChIP_HESCs_Human0.85713667
155TBX3_20139965_ChIP-Seq_ESCs_Mouse0.84429706
156KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.83355011
157TBX3_20139965_ChIP-Seq_MESCs_Mouse0.82530154
158KAP1_27257070_Chip-Seq_ESCs_Mouse0.81105761
159CREB1_15753290_ChIP-ChIP_HEK293T_Human0.76949170
160MYB_26560356_Chip-Seq_TH1_Human0.76202848
161E2F1_21310950_ChIP-Seq_MCF-7_Human0.76131005
162VDR_21846776_ChIP-Seq_THP-1_Human0.72393627
163MYCN_18555785_ChIP-Seq_MESCs_Mouse0.71823144
164KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.70473592
165FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.68977218
166KDM2B_26808549_Chip-Seq_DND41_Human0.67631335
167RACK7_27058665_Chip-Seq_MCF-7_Human0.67595333
168EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.67543098
169STAT3_18555785_ChIP-Seq_MESCs_Mouse0.67238876
170TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.66665744
171* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.66328919
172E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.65653402
173NELFA_20434984_ChIP-Seq_ESCs_Mouse0.65481655
174TFEB_21752829_ChIP-Seq_HELA_Human0.64858764
175WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.64657760

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004264_abnormal_extraembryonic_tissu4.21900819
2MP0002254_reproductive_system_inflammat3.96764440
3MP0008057_abnormal_DNA_replication3.64137194
4MP0003890_abnormal_embryonic-extraembry3.58140490
5MP0003011_delayed_dark_adaptation3.42799545
6MP0006292_abnormal_olfactory_placode3.37740833
7MP0005451_abnormal_body_composition3.16716562
8MP0003705_abnormal_hypodermis_morpholog2.98348920
9MP0004957_abnormal_blastocyst_morpholog2.90105930
10MP0005075_abnormal_melanosome_morpholog2.88711485
11MP0010352_gastrointestinal_tract_polyps2.87079399
12MP0005394_taste/olfaction_phenotype2.68168409
13MP0005499_abnormal_olfactory_system2.68168409
14MP0004858_abnormal_nervous_system2.48422496
15MP0002332_abnormal_exercise_endurance2.29735568
16MP0005257_abnormal_intraocular_pressure2.23263039
17MP0003121_genomic_imprinting2.22776755
18MP0003763_abnormal_thymus_physiology2.13560698
19MP0003122_maternal_imprinting2.12554359
20MP0005380_embryogenesis_phenotype2.10660554
21MP0001672_abnormal_embryogenesis/_devel2.10660554
22MP0003091_abnormal_cell_migration2.04325423
23MP0002009_preneoplasia2.03635840
24MP0002088_abnormal_embryonic_growth/wei1.98844708
25MP0003984_embryonic_growth_retardation1.97899630
26MP0003077_abnormal_cell_cycle1.93481059
27MP0002396_abnormal_hematopoietic_system1.91577628
28MP0000350_abnormal_cell_proliferation1.84182836
29MP0003111_abnormal_nucleus_morphology1.81748806
30MP0004185_abnormal_adipocyte_glucose1.75971900
31MP0001849_ear_inflammation1.74266592
32MP0003300_gastrointestinal_ulcer1.72944223
33MP0008961_abnormal_basal_metabolism1.71889862
34MP0004233_abnormal_muscle_weight1.66371534
35MP0002166_altered_tumor_susceptibility1.66174865
36MP0006035_abnormal_mitochondrial_morpho1.66008104
37MP0002653_abnormal_ependyma_morphology1.65696331
38MP0002086_abnormal_extraembryonic_tissu1.64600055
39MP0010094_abnormal_chromosome_stability1.60757169
40MP0000678_abnormal_parathyroid_gland1.58736160
41MP0003221_abnormal_cardiomyocyte_apopto1.57608423
42MP0009278_abnormal_bone_marrow1.57388775
43MP0008260_abnormal_autophagy1.55921507
44MP0005409_darkened_coat_color1.55107931
45MP0004947_skin_inflammation1.55091762
46MP0001835_abnormal_antigen_presentation1.54023718
47MP0003191_abnormal_cellular_cholesterol1.52858813
48MP0003453_abnormal_keratinocyte_physiol1.51925045
49MP0003183_abnormal_peptide_metabolism1.51495114
50MP0001545_abnormal_hematopoietic_system1.50873988
51MP0005397_hematopoietic_system_phenotyp1.50873988
52MP0001293_anophthalmia1.50694733
53MP0010234_abnormal_vibrissa_follicle1.45995438
54MP0003436_decreased_susceptibility_to1.43576722
55MP0002277_abnormal_respiratory_mucosa1.43186302
56MP0003656_abnormal_erythrocyte_physiolo1.42436845
57MP0002085_abnormal_embryonic_tissue1.40208313
58MP0006082_CNS_inflammation1.40204452
59MP0002127_abnormal_cardiovascular_syste1.40018235
60MP0003303_peritoneal_inflammation1.36094754
61MP0002092_abnormal_eye_morphology1.34705475
62MP0003123_paternal_imprinting1.34530856
63MP0002084_abnormal_developmental_patter1.34141909
64MP0004197_abnormal_fetal_growth/weight/1.33498100
65MP0003938_abnormal_ear_development1.32303340
66MP0002006_tumorigenesis1.31815719
67MP0001730_embryonic_growth_arrest1.28538150
68MP0003787_abnormal_imprinting1.20576539
69MP0002932_abnormal_joint_morphology1.19990953
70MP0000490_abnormal_crypts_of1.19728585
71MP0002060_abnormal_skin_morphology1.19546296
72MP0009840_abnormal_foam_cell1.18393348
73MP0001800_abnormal_humoral_immune1.18073367
74MP0002796_impaired_skin_barrier1.18012954
75MP0010030_abnormal_orbit_morphology1.17965780
76MP0003950_abnormal_plasma_membrane1.17641957
77MP0000313_abnormal_cell_death1.12544725
78MP0002998_abnormal_bone_remodeling1.12137153
79MP0001915_intracranial_hemorrhage1.10755108
80MP0000685_abnormal_immune_system1.10540552
81MP0001853_heart_inflammation1.10373049
82MP0000432_abnormal_head_morphology1.10104250
83MP0001697_abnormal_embryo_size1.09845698
84MP0003172_abnormal_lysosome_physiology1.09705563
85MP0003693_abnormal_embryo_hatching1.09071652
86MP0009333_abnormal_splenocyte_physiolog1.08719560
87MP0008438_abnormal_cutaneous_collagen1.07501242
88MP0002452_abnormal_antigen_presenting1.06559815
89MP0005023_abnormal_wound_healing1.06278019
90MP0002925_abnormal_cardiovascular_devel1.05391192
91MP0008007_abnormal_cellular_replicative1.05070258
92MP0002419_abnormal_innate_immunity1.04921839
93MP0003935_abnormal_craniofacial_develop1.04783467
94MP0000733_abnormal_muscle_development1.01987993
95MP0005266_abnormal_metabolism1.01749243
96MP0000428_abnormal_craniofacial_morphol1.00273288
97MP0002080_prenatal_lethality1.00271161
98MP0000371_diluted_coat_color0.99935616
99MP0000762_abnormal_tongue_morphology0.99408100
100MP0005387_immune_system_phenotype0.99281797
101MP0001790_abnormal_immune_system0.99281797
102MP0000015_abnormal_ear_pigmentation0.99009377
103MP0005666_abnormal_adipose_tissue0.97925707
104MP0005501_abnormal_skin_physiology0.96856947
105MP0008770_decreased_survivor_rate0.96834782
106MP0000049_abnormal_middle_ear0.96560199
107MP0002970_abnormal_white_adipose0.96284335
108MP0002420_abnormal_adaptive_immunity0.96155437
109MP0002233_abnormal_nose_morphology0.94946839
110MP0001819_abnormal_immune_cell0.94256580
111MP0005076_abnormal_cell_differentiation0.94199154
112MP0002114_abnormal_axial_skeleton0.93964144
113MP0002723_abnormal_immune_serum0.93296558
114MP0005000_abnormal_immune_tolerance0.92914670
115MP0003755_abnormal_palate_morphology0.92655423
116MP0003119_abnormal_digestive_system0.90828123
117MP0008789_abnormal_olfactory_epithelium0.90688250
118MP0009703_decreased_birth_body0.90534181
119MP0000716_abnormal_immune_system0.90009703
120MP0001851_eye_inflammation0.89911761
121MP0001216_abnormal_epidermal_layer0.89445075
122MP0005375_adipose_tissue_phenotype0.88594217
123MP0005464_abnormal_platelet_physiology0.87196569
124MP0002405_respiratory_system_inflammati0.86977134
125MP0005310_abnormal_salivary_gland0.86945635
126MP0002429_abnormal_blood_cell0.86162163
127MP0002089_abnormal_postnatal_growth/wei0.86074614
128MP0005248_abnormal_Harderian_gland0.85069529
129MP0001348_abnormal_lacrimal_gland0.84932778
130MP0003448_altered_tumor_morphology0.83678051
131MP0005058_abnormal_lysosome_morphology0.83670481
132MP0008932_abnormal_embryonic_tissue0.83583099
133MP0009931_abnormal_skin_appearance0.83030486
134MP0003566_abnormal_cell_adhesion0.82723103
135MP0005025_abnormal_response_to0.81488291
136MP0003828_pulmonary_edema0.80614059
137MP0002019_abnormal_tumor_incidence0.79588811
138MP0005508_abnormal_skeleton_morphology0.78207504
139MP0002877_abnormal_melanocyte_morpholog0.77970037
140MP0004381_abnormal_hair_follicle0.73425834
141MP0002722_abnormal_immune_system0.72140318
142MP0004133_heterotaxia0.71094236
143MP0000689_abnormal_spleen_morphology0.70475436
144MP0005384_cellular_phenotype0.69900083
145MP0010307_abnormal_tumor_latency0.68766739
146MP0000750_abnormal_muscle_regeneration0.68190771
147MP0004808_abnormal_hematopoietic_stem0.68055835
148MP0003786_premature_aging0.66872735
149MP0002116_abnormal_craniofacial_bone0.66525875
150MP0005391_vision/eye_phenotype0.65407475
151MP0000858_altered_metastatic_potential0.64673358
152MP0003937_abnormal_limbs/digits/tail_de0.64251812
153MP0000383_abnormal_hair_follicle0.64082377
154MP0002132_abnormal_respiratory_system0.61782492
155MP0005621_abnormal_cell_physiology0.61477171
156MP0002398_abnormal_bone_marrow0.60930774
157MP0000703_abnormal_thymus_morphology0.60731146
158MP0009115_abnormal_fat_cell0.60481137
159MP0002098_abnormal_vibrissa_morphology0.59732483
160MP0001286_abnormal_eye_development0.59165543

Predicted human phenotypes

RankGene SetZ-score
1Bilateral microphthalmos (HP:0007633)6.52074901
2Hypochromic microcytic anemia (HP:0004840)6.10904574
3Hepatoblastoma (HP:0002884)4.90466952
4Multiple enchondromatosis (HP:0005701)4.60129512
5Rib fusion (HP:0000902)4.54545322
6Abnormality of the lower motor neuron (HP:0002366)4.53695352
7Ependymoma (HP:0002888)4.44694085
8Chromosomal breakage induced by crosslinking agents (HP:0003221)4.07741513
9Neoplasm of striated muscle (HP:0009728)3.79256852
10Chromsome breakage (HP:0040012)3.70218247
11Rhabdomyosarcoma (HP:0002859)3.69889098
12Nephroblastoma (Wilms tumor) (HP:0002667)3.54598820
13Embryonal renal neoplasm (HP:0011794)3.28448074
14Abnormality of the astrocytes (HP:0100707)3.27427350
15Astrocytoma (HP:0009592)3.27427350
16Intestinal fistula (HP:0100819)3.09562346
17Rectovaginal fistula (HP:0000143)3.09201892
18Rectal fistula (HP:0100590)3.09201892
19Fused cervical vertebrae (HP:0002949)3.06689142
20Abnormality of the fingertips (HP:0001211)2.90742442
21Abnormality of the salivary glands (HP:0010286)2.88545592
22Testicular atrophy (HP:0000029)2.87633211
23Aplasia/Hypoplasia of the fovea (HP:0008060)2.80310148
24Hypoplasia of the fovea (HP:0007750)2.80310148
25Short humerus (HP:0005792)2.78772783
26Impulsivity (HP:0100710)2.77772723
27Hypochromic anemia (HP:0001931)2.76025289
28Ankyloglossia (HP:0010296)2.75863745
29Progressive external ophthalmoplegia (HP:0000590)2.74557816
30Aplasia/hypoplasia of the humerus (HP:0006507)2.73185349
31Colitis (HP:0002583)2.70667767
32Large earlobe (HP:0009748)2.70644133
33Preauricular skin tag (HP:0000384)2.63470826
34Vaginal fistula (HP:0004320)2.61989143
35Amyotrophic lateral sclerosis (HP:0007354)2.61936638
36Abnormality of oral frenula (HP:0000190)2.60681084
37Syringomyelia (HP:0003396)2.58824270
38Spinal cord lesions (HP:0100561)2.58824270
39Meckel diverticulum (HP:0002245)2.56056736
40Partial duplication of thumb phalanx (HP:0009944)2.53059339
41Aplasia/Hypoplasia of the uvula (HP:0010293)2.52150115
42Recurrent viral infections (HP:0004429)2.50866224
43Trismus (HP:0000211)2.50723356
44Glioma (HP:0009733)2.50056383
45Abnormal lung lobation (HP:0002101)2.48165187
46Skin tags (HP:0010609)2.48038477
47Hyperacusis (HP:0010780)2.47408129
48Shawl scrotum (HP:0000049)2.44259230
49Abnormal cartilage morphology (HP:0002763)2.43682390
50Abnormality of chromosome segregation (HP:0002916)2.42652165
51Hyperinsulinemic hypoglycemia (HP:0000825)2.42018816
52Dysmetric saccades (HP:0000641)2.41654972
53Increased connective tissue (HP:0009025)2.41260176
54Abnormality of the ileum (HP:0001549)2.39969216
55Long eyelashes (HP:0000527)2.39696115
56Prominent nose (HP:0000448)2.38479198
57Ragged-red muscle fibers (HP:0003200)2.37575974
58Preauricular pit (HP:0004467)2.35720893
59Periauricular skin pits (HP:0100277)2.35720893
60Heterotopia (HP:0002282)2.35594220
61Bifid tongue (HP:0010297)2.34787785
62Viral hepatitis (HP:0006562)2.34000987
63Horizontal nystagmus (HP:0000666)2.33787052
64Osteolytic defects of the phalanges of the hand (HP:0009771)2.33407476
65Osteolytic defects of the hand bones (HP:0009699)2.33407476
66Upper motor neuron abnormality (HP:0002127)2.32763322
67Volvulus (HP:0002580)2.32300035
68Subacute progressive viral hepatitis (HP:0006572)2.31945617
69Abnormality of the distal phalanx of the thumb (HP:0009617)2.31341294
70Broad face (HP:0000283)2.25224032
71Anomalous pulmonary venous return (HP:0010772)2.24229533
72Short 5th finger (HP:0009237)2.23402549
73Difficulty running (HP:0009046)2.22823275
74Distal lower limb amyotrophy (HP:0008944)2.22138319
75Partial duplication of the phalanx of hand (HP:0009999)2.20711848
76Medulloblastoma (HP:0002885)2.19687669
77Acute myeloid leukemia (HP:0004808)2.19418249
78Eczematoid dermatitis (HP:0000976)2.17858061
79Dislocated radial head (HP:0003083)2.15144431
80Supernumerary ribs (HP:0005815)2.14298314
81Pseudobulbar signs (HP:0002200)2.13850125
82Hand muscle atrophy (HP:0009130)2.13640750
83Generalized hypotonia (HP:0001290)2.10383066
84Abnormality of the phalanges of the hallux (HP:0010057)2.09255085
85Combined immunodeficiency (HP:0005387)2.09138663
86Hypopigmentation of the fundus (HP:0007894)2.09049964
87Flat acetabular roof (HP:0003180)2.07799635
88Slow saccadic eye movements (HP:0000514)2.06546486
89Deep philtrum (HP:0002002)2.05709345
90Ulnar bowing (HP:0003031)2.04021139
91Hereditary nonpolyposis colorectal carcinoma (HP:0006716)2.04016650
92Aplasia/Hypoplasia of the sternum (HP:0006714)2.03496693
93Recurrent bacterial skin infections (HP:0005406)2.03094284
94Fatigue (HP:0012378)2.03037934
95Renal duplication (HP:0000075)2.02910480
96Aplasia/Hypoplasia of the macula (HP:0008059)2.02534898
97Duodenal stenosis (HP:0100867)2.01777334
98Small intestinal stenosis (HP:0012848)2.01777334
99Abnormality of the musculature of the hand (HP:0001421)2.01629259
100Malignant neoplasm of the central nervous system (HP:0100836)2.00446759
101Vertebral fusion (HP:0002948)1.99732354
102Supernumerary spleens (HP:0009799)1.99686449
103Uterine leiomyosarcoma (HP:0002891)1.99458402
104Leiomyosarcoma (HP:0100243)1.99458402
105Skin pits (HP:0100276)1.98793191
106Aplasia/Hypoplasia of the 5th finger (HP:0006262)1.97445312
107Vertebral arch anomaly (HP:0008438)1.97133394
108Absent frontal sinuses (HP:0002688)1.96946584
109Abnormality of the fovea (HP:0000493)1.95488437
110Sparse lateral eyebrow (HP:0005338)1.95436030
111Cheilitis (HP:0100825)1.95214118
112Arterial tortuosity (HP:0005116)1.94884583
113Tongue fasciculations (HP:0001308)1.94464229
114Nasolacrimal duct obstruction (HP:0000579)1.93113147
115Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.92643709
116Recurrent abscess formation (HP:0002722)1.91712224
117Abnormality of small intestinal villus morphology (HP:0011472)1.91492671
118Villous atrophy (HP:0011473)1.91492671
119Neonatal hypoglycemia (HP:0001998)1.90652406
120Abnormality of the pubic bones (HP:0003172)1.90543545
121Selective tooth agenesis (HP:0001592)1.90312271
122Gastrointestinal inflammation (HP:0004386)1.89939675
123Abnormality of the radial head (HP:0003995)1.89566648
124Abnormality of the pulmonary veins (HP:0011718)1.89212676
125Supernumerary bones of the axial skeleton (HP:0009144)1.88865597
126Persistence of primary teeth (HP:0006335)1.88147663
127Neoplasm of the heart (HP:0100544)1.88053643
128Tetraplegia (HP:0002445)1.87201392
129Neoplasm of the oral cavity (HP:0100649)1.86800701
130Centrally nucleated skeletal muscle fibers (HP:0003687)1.86409672
131Myelodysplasia (HP:0002863)1.86049457
132Mitral valve prolapse (HP:0001634)1.86031221
133Malignant gastrointestinal tract tumors (HP:0006749)1.85262331
134Gastrointestinal carcinoma (HP:0002672)1.85262331
135Spinal muscular atrophy (HP:0007269)1.85155355
136Cellulitis (HP:0100658)1.84969973
137Progressive muscle weakness (HP:0003323)1.84245238
138Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.83882994
139Resting tremor (HP:0002322)1.83571740
140Glossoptosis (HP:0000162)1.83490124
141Reduced antithrombin III activity (HP:0001976)1.83387832
142Abnormality of the thoracic spine (HP:0100711)1.82714927
143Myocardial infarction (HP:0001658)1.82702364
144Gingivitis (HP:0000230)1.82341625
145Renal cell carcinoma (HP:0005584)1.82111894
146Supernumerary nipples (HP:0002558)1.81280737
147Inflammation of the large intestine (HP:0002037)1.80266443
148Deep palmar crease (HP:0006191)1.79940230
149Muscle fibrillation (HP:0010546)1.79616244
150Sensory axonal neuropathy (HP:0003390)1.79295150
151IgA deficiency (HP:0002720)1.78606643
152Missing ribs (HP:0000921)1.78595470
153Neoplasm of the adrenal cortex (HP:0100641)1.78119821
154Atresia of the external auditory canal (HP:0000413)1.77747843
155Cerebral aneurysm (HP:0004944)1.76998565
156Transitional cell carcinoma of the bladder (HP:0006740)1.76270758
157Urethral obstruction (HP:0000796)1.73555275
158Protrusio acetabuli (HP:0003179)1.72948624
159T lymphocytopenia (HP:0005403)1.71630191
160Overlapping toe (HP:0001845)1.71262357
161Thoracolumbar scoliosis (HP:0002944)1.70733955
162Dilatation of the ascending aorta (HP:0005111)1.69952232
163Abnormality of skeletal muscle fiber size (HP:0012084)1.69124203
164Bladder neoplasm (HP:0009725)1.68523456
165Bladder carcinoma (HP:0002862)1.68523456
166Sandal gap (HP:0001852)1.66632876
167Spondylolisthesis (HP:0003302)1.65804420
168Vascular tortuosity (HP:0004948)1.63441528
169Aneurysm (HP:0002617)1.63121854
170Narrow palate (HP:0000189)1.62094558
171Abnormal delayed hypersensitivity skin test (HP:0002963)1.61946446
172Recurrent cutaneous fungal infections (HP:0011370)1.61871788
173Chronic mucocutaneous candidiasis (HP:0002728)1.61871788
174Abnormality of the columella (HP:0009929)1.61376509
175Coarse hair (HP:0002208)1.60970596
176Distal upper limb amyotrophy (HP:0007149)1.59794968
177Upper limb amyotrophy (HP:0009129)1.59794968
178Disproportionate tall stature (HP:0001519)1.59506815
179Obstructive sleep apnea (HP:0002870)1.58025849
180Advanced eruption of teeth (HP:0006288)1.57294562
181Autoimmune hemolytic anemia (HP:0001890)1.54217640
182Deviation of the thumb (HP:0009603)1.53613913
183Lower limb amyotrophy (HP:0007210)1.53435256
184Recurrent fungal infections (HP:0002841)1.53104706
185Long palpebral fissure (HP:0000637)1.53016599
186Hepatitis (HP:0012115)1.52520198
187Papillary thyroid carcinoma (HP:0002895)1.51546939
188Increased variability in muscle fiber diameter (HP:0003557)1.51537792
189Low anterior hairline (HP:0000294)1.51460105
190Spontaneous hematomas (HP:0007420)1.51368862
191Distal lower limb muscle weakness (HP:0009053)1.49767435
192Relative macrocephaly (HP:0004482)1.49335101
193Mitral regurgitation (HP:0001653)1.48716482
194Progressive hearing impairment (HP:0001730)1.48497786
195Osteomyelitis (HP:0002754)1.48235535

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK128.97844064
2ERN14.30366696
3GRK54.25096315
4GRK63.92008060
5PRPF4B3.81534724
6TRIB32.91763655
7CSF1R2.78923904
8TTK2.73205155
9TYRO32.66429170
10GRK12.57085360
11STK102.53117674
12TGFBR22.52332615
13ADRBK22.39482280
14IRAK32.32326519
15SMG12.27622828
16MST1R2.22774993
17MAPK72.13564349
18MATK2.09850659
19GRK71.89934315
20WNK11.84930924
21CAMK1D1.79456590
22MAP3K101.75407842
23CAMK1G1.70685506
24MOS1.65187343
25MAP2K31.64435023
26CDK71.61382306
27FGFR31.55072172
28MAP3K131.52836406
29MAP3K141.47209801
30CAMK41.41085808
31FGFR41.31350148
32EPHA21.29539639
33CHEK21.26569062
34PBK1.24845360
35EIF2AK11.21584117
36PRKG21.20618173
37TRPM71.18263555
38PAK41.17132771
39MARK21.15552192
40CDC71.14635446
41PLK11.14495136
42MET1.14482376
43SCYL21.11544431
44BLK1.10787000
45HIPK21.10277502
46TYK21.10194986
47ALK1.08195512
48NEK21.07171905
49MAP3K11.04891319
50CSK1.01663650
51RIPK41.01414052
52AKT31.00957597
53CHEK10.98944526
54JAK10.98805383
55MAP3K30.95925078
56SGK30.95144809
57JAK30.92831946
58NEK90.89511191
59NTRK10.86552215
60MTOR0.84868301
61MAP3K70.83641882
62MAPK110.82672424
63IRAK40.81483784
64PDPK10.79898290
65BMPR20.78531778
66MAP2K40.78324871
67MAP3K20.78321090
68ZAP700.76756522
69PDGFRA0.76043109
70ADRBK10.75872269
71CDC42BPA0.75584374
72CDK40.73480530
73AKT20.71920708
74EIF2AK30.71060380
75KSR20.66722938
76TAOK20.66202795
77RIPK10.65353532
78PDK10.65200453
79CDK20.62884889
80MARK30.61901863
81EIF2AK20.61451707
82RPS6KB20.60763267
83RPS6KB10.60129584
84BTK0.59533391
85IRAK20.59318545
86NLK0.58628044
87CHUK0.58471879
88IKBKB0.58060845
89CDK80.57664838
90ATM0.57107806
91BRD40.56550621
92TBK10.55004571
93SGK20.54294440
94ITK0.53382232
95EPHB10.52540871
96AURKB0.51821728
97PIK3CG0.49301204
98FGR0.49010285
99STK240.47163089
100NEK60.46786267
101LATS20.45453041
102DMPK0.44751480
103MAP2K60.44499010
104MAPK120.43947885
105STK40.43667861
106IKBKE0.43413948
107MAPKAPK20.43354580
108MAP3K60.43219457
109YES10.43035775
110ERBB40.41977433
111PIM10.41583924
112NME20.41483039
113BMX0.40331567
114SIK20.38942981
115ATR0.37841855
116STK30.37627645
117PTK20.35880587
118CDK10.35717474
119WEE10.35361514
120CSNK1E0.34707719
121DDR20.34039442
122MAPK100.33378305
123SIK10.33297227
124MAPK10.32932554
125LATS10.32873213
126IGF1R0.32803124
127MAPK140.32030987
128SRPK10.31782457
129ICK0.30761740
130NEK10.30734526
131PRKCI0.29571273
132MAP4K10.29379492
133ERBB20.28297324
134INSR0.27465018
135GSK3B0.26954590
136CDK60.25987278
137MELK0.25761883
138ACVR1B0.25260929
139PKN20.24507627
140GSK3A0.23201528
141EEF2K0.23158828
142HCK0.23089019
143MAP3K80.22542470
144PRKCD0.21871262
145PDGFRB0.21296684
146FLT30.21171205
147PAK10.20582476
148PRKD20.20518507
149AURKA0.20486371
150AKT10.18679446
151STK380.18322126
152CSNK1D0.17366798
153TAOK10.17009465
154DYRK1B0.16870730
155PRKAA10.16781532
156TTN0.16228677

Predicted pathways (KEGG)

RankGene SetZ-score
1Vitamin B6 metabolism_Homo sapiens_hsa007504.76003254
2Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006034.73480307
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.94334903
4Fructose and mannose metabolism_Homo sapiens_hsa000512.82629349
5RNA transport_Homo sapiens_hsa030132.03290855
6Galactose metabolism_Homo sapiens_hsa000521.98707142
7mRNA surveillance pathway_Homo sapiens_hsa030151.82091661
8One carbon pool by folate_Homo sapiens_hsa006701.77660394
9Arachidonic acid metabolism_Homo sapiens_hsa005901.75487136
10Fanconi anemia pathway_Homo sapiens_hsa034601.73128507
11mTOR signaling pathway_Homo sapiens_hsa041501.70099675
12Prostate cancer_Homo sapiens_hsa052151.69589614
13Renal cell carcinoma_Homo sapiens_hsa052111.58914844
14Endometrial cancer_Homo sapiens_hsa052131.57438247
15Cell cycle_Homo sapiens_hsa041101.56226527
16Osteoclast differentiation_Homo sapiens_hsa043801.53294164
17DNA replication_Homo sapiens_hsa030301.49112584
18Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.48783018
19Thyroid cancer_Homo sapiens_hsa052161.47230181
20Hepatitis B_Homo sapiens_hsa051611.45125508
21Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.41698612
22AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.41269948
23Transcriptional misregulation in cancer_Homo sapiens_hsa052021.39964304
24Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.38943829
25RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.38872910
26Hepatitis C_Homo sapiens_hsa051601.38734062
27Mismatch repair_Homo sapiens_hsa034301.34546454
28Toll-like receptor signaling pathway_Homo sapiens_hsa046201.31137958
29Glioma_Homo sapiens_hsa052141.30478400
30MicroRNAs in cancer_Homo sapiens_hsa052061.30174185
31RNA degradation_Homo sapiens_hsa030181.23516067
32Linoleic acid metabolism_Homo sapiens_hsa005911.23081841
33FoxO signaling pathway_Homo sapiens_hsa040681.22624756
34alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.22043093
35Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.21845393
36Herpes simplex infection_Homo sapiens_hsa051681.21192614
37Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.20950914
38Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.19169772
39Pentose and glucuronate interconversions_Homo sapiens_hsa000401.16689959
40Homologous recombination_Homo sapiens_hsa034401.16302385
41NF-kappa B signaling pathway_Homo sapiens_hsa040641.14886777
42p53 signaling pathway_Homo sapiens_hsa041151.14052206
43ErbB signaling pathway_Homo sapiens_hsa040121.12449298
44Acute myeloid leukemia_Homo sapiens_hsa052211.08550754
45Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.08454583
46Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.07694253
47Prolactin signaling pathway_Homo sapiens_hsa049171.07599867
48Spliceosome_Homo sapiens_hsa030401.06405057
49Base excision repair_Homo sapiens_hsa034101.03239926
50Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.01907042
51Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.99942452
52Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.97395128
53Inositol phosphate metabolism_Homo sapiens_hsa005620.96982287
54Dorso-ventral axis formation_Homo sapiens_hsa043200.96217478
55Thyroid hormone signaling pathway_Homo sapiens_hsa049190.94449701
56Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.94050091
57Regulation of actin cytoskeleton_Homo sapiens_hsa048100.93772535
58Insulin signaling pathway_Homo sapiens_hsa049100.93577034
59Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.93197104
60Viral myocarditis_Homo sapiens_hsa054160.93089332
61Tuberculosis_Homo sapiens_hsa051520.91822611
62Central carbon metabolism in cancer_Homo sapiens_hsa052300.91729502
63Platelet activation_Homo sapiens_hsa046110.89246220
64Epstein-Barr virus infection_Homo sapiens_hsa051690.89095926
65Pathways in cancer_Homo sapiens_hsa052000.88302696
66Lysine degradation_Homo sapiens_hsa003100.87028023
67Notch signaling pathway_Homo sapiens_hsa043300.85257381
68Non-small cell lung cancer_Homo sapiens_hsa052230.84457618
69Small cell lung cancer_Homo sapiens_hsa052220.83669809
70Apoptosis_Homo sapiens_hsa042100.83213880
71Adherens junction_Homo sapiens_hsa045200.82419278
72Phospholipase D signaling pathway_Homo sapiens_hsa040720.81891669
73Sphingolipid signaling pathway_Homo sapiens_hsa040710.80905234
74B cell receptor signaling pathway_Homo sapiens_hsa046620.79789186
75Basal cell carcinoma_Homo sapiens_hsa052170.79498047
76GnRH signaling pathway_Homo sapiens_hsa049120.78986136
77Primary immunodeficiency_Homo sapiens_hsa053400.77864738
78NOD-like receptor signaling pathway_Homo sapiens_hsa046210.77465173
79Proteoglycans in cancer_Homo sapiens_hsa052050.75576150
80Amoebiasis_Homo sapiens_hsa051460.74685003
81Leukocyte transendothelial migration_Homo sapiens_hsa046700.74118563
82Viral carcinogenesis_Homo sapiens_hsa052030.73909840
83Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.73639974
84Adipocytokine signaling pathway_Homo sapiens_hsa049200.72329451
85Melanoma_Homo sapiens_hsa052180.71579051
86HTLV-I infection_Homo sapiens_hsa051660.71403504
87Glycosaminoglycan degradation_Homo sapiens_hsa005310.69384809
88Estrogen signaling pathway_Homo sapiens_hsa049150.69197356
89Intestinal immune network for IgA production_Homo sapiens_hsa046720.69045708
90Pancreatic cancer_Homo sapiens_hsa052120.67989072
91Choline metabolism in cancer_Homo sapiens_hsa052310.67908758
92Influenza A_Homo sapiens_hsa051640.66331527
93Leishmaniasis_Homo sapiens_hsa051400.65220079
94Chemokine signaling pathway_Homo sapiens_hsa040620.65177177
95T cell receptor signaling pathway_Homo sapiens_hsa046600.65172795
96Shigellosis_Homo sapiens_hsa051310.63699407
97Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.63692373
98Phosphatidylinositol signaling system_Homo sapiens_hsa040700.63338337
99Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.63115938
100HIF-1 signaling pathway_Homo sapiens_hsa040660.62909497
101African trypanosomiasis_Homo sapiens_hsa051430.61505061
102Rap1 signaling pathway_Homo sapiens_hsa040150.60644339
103Hippo signaling pathway_Homo sapiens_hsa043900.60144287
104Ovarian steroidogenesis_Homo sapiens_hsa049130.59132203
105Non-homologous end-joining_Homo sapiens_hsa034500.57705856
106MAPK signaling pathway_Homo sapiens_hsa040100.55784959
107Malaria_Homo sapiens_hsa051440.55397111
108Bladder cancer_Homo sapiens_hsa052190.55356516
109Colorectal cancer_Homo sapiens_hsa052100.55339757
110Endocytosis_Homo sapiens_hsa041440.54020213
111Other glycan degradation_Homo sapiens_hsa005110.53482056
112Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.52501502
113Jak-STAT signaling pathway_Homo sapiens_hsa046300.52089782
114Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.51291002
115VEGF signaling pathway_Homo sapiens_hsa043700.51226077
116Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.48101810
117Chronic myeloid leukemia_Homo sapiens_hsa052200.47593181
118Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.46059346
119Hedgehog signaling pathway_Homo sapiens_hsa043400.45951433
120Toxoplasmosis_Homo sapiens_hsa051450.45878645
121Wnt signaling pathway_Homo sapiens_hsa043100.45757701
122Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.45616137
123AMPK signaling pathway_Homo sapiens_hsa041520.43778780
124Basal transcription factors_Homo sapiens_hsa030220.42956064
125Insulin resistance_Homo sapiens_hsa049310.41651733
126Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.41086182
127TGF-beta signaling pathway_Homo sapiens_hsa043500.39083740
128Neurotrophin signaling pathway_Homo sapiens_hsa047220.39002722
129Pentose phosphate pathway_Homo sapiens_hsa000300.38985234
130Legionellosis_Homo sapiens_hsa051340.38751908
131Hematopoietic cell lineage_Homo sapiens_hsa046400.38709595
132PI3K-Akt signaling pathway_Homo sapiens_hsa041510.38468095
133Measles_Homo sapiens_hsa051620.37893170
134Longevity regulating pathway - mammal_Homo sapiens_hsa042110.36303951
135Antigen processing and presentation_Homo sapiens_hsa046120.34624976
136Focal adhesion_Homo sapiens_hsa045100.34009821
137Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.33775568
138Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.32450849
139Selenocompound metabolism_Homo sapiens_hsa004500.31967272
140TNF signaling pathway_Homo sapiens_hsa046680.31619802

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