INO80B-WBP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This locus represents naturally occurring read-through transcription between the neighboring INO80B (INO80 complex subunit B) and WBP1 (WW domain-binding protein 1) genes on chromosome 2. The read-through transcript is a candidate for nonsense-mediated mRNA decay (NMD), and is unlikely to produce a protein product. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)4.29493915
2NIK/NF-kappaB signaling (GO:0038061)4.14655612
3protein localization to endosome (GO:0036010)3.73061603
4negative regulation of erythrocyte differentiation (GO:0045647)3.71646108
5positive regulation by symbiont of host defense response (GO:0052509)3.58736792
6modulation by symbiont of host defense response (GO:0052031)3.58736792
7modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.58736792
8modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.58736792
9positive regulation by organism of defense response of other organism involved in symbiotic interact3.58736792
10modulation by symbiont of host immune response (GO:0052553)3.58736792
11response to peptidoglycan (GO:0032494)3.52149545
12positive regulation of Cdc42 GTPase activity (GO:0043089)3.46976993
13modulation by symbiont of host cellular process (GO:0044068)3.40039140
14COPI coating of Golgi vesicle (GO:0048205)3.38298912
15Golgi transport vesicle coating (GO:0048200)3.38298912
16antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.35262164
17myeloid dendritic cell differentiation (GO:0043011)3.30622454
18regulation of early endosome to late endosome transport (GO:2000641)3.27938428
19antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.21030405
20pentose-phosphate shunt (GO:0006098)3.18862792
21negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.11571644
22negative regulation of cell killing (GO:0031342)3.11571644
23modulation by virus of host process (GO:0019054)3.07438924
24antigen processing and presentation of endogenous antigen (GO:0019883)3.07331129
25lipopolysaccharide-mediated signaling pathway (GO:0031663)3.03266021
26regulation of defense response to virus by virus (GO:0050690)3.00527112
27barbed-end actin filament capping (GO:0051016)2.97943630
28regulation of T-helper 2 cell differentiation (GO:0045628)2.97548962
29leukocyte aggregation (GO:0070486)2.96178095
30detection of bacterium (GO:0016045)2.86752232
31antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.82237593
32detection of other organism (GO:0098543)2.78319801
33mannose metabolic process (GO:0006013)2.77804970
34endoplasmic reticulum calcium ion homeostasis (GO:0032469)2.77489826
35regulation of mammary gland epithelial cell proliferation (GO:0033599)2.74977054
363-UTR-mediated mRNA stabilization (GO:0070935)2.74440236
37macrophage activation involved in immune response (GO:0002281)2.73659825
38positive regulation of protein dephosphorylation (GO:0035307)2.73030321
39immunoglobulin mediated immune response (GO:0016064)2.71664441
40response to muramyl dipeptide (GO:0032495)2.71293415
41myeloid dendritic cell activation (GO:0001773)2.70859060
42germinal center formation (GO:0002467)2.70786646
43pinocytosis (GO:0006907)2.70478776
44stress fiber assembly (GO:0043149)2.69791629
45retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.68687448
46proline biosynthetic process (GO:0006561)2.65956188
47cellular response to type I interferon (GO:0071357)2.65353748
48type I interferon signaling pathway (GO:0060337)2.65353748
49maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.65145388
50NADPH regeneration (GO:0006740)2.64133622
51regulation of extracellular matrix disassembly (GO:0010715)2.63395967
52ribosomal small subunit biogenesis (GO:0042274)2.63226578
53response to type I interferon (GO:0034340)2.62242595
54protein retention in ER lumen (GO:0006621)2.62192336
55amyloid precursor protein catabolic process (GO:0042987)2.61088280
56neutrophil activation involved in immune response (GO:0002283)2.60649976
57positive regulation of gamma-delta T cell activation (GO:0046645)2.60176572
58glucose catabolic process (GO:0006007)2.59505875
59negative regulation of interleukin-12 production (GO:0032695)2.59434413
60regulation of leukocyte degranulation (GO:0043300)2.56227603
61apoptotic process involved in morphogenesis (GO:0060561)2.54529582
62response to laminar fluid shear stress (GO:0034616)2.51837722
63maternal placenta development (GO:0001893)2.51725132
64adenosine receptor signaling pathway (GO:0001973)2.51550598
65response to host (GO:0075136)2.51376497
66response to host defenses (GO:0052200)2.51376497
67response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.51376497
68virion assembly (GO:0019068)2.50820632
69positive regulation of extracellular matrix organization (GO:1903055)2.47212108
70activation of MAPKKK activity (GO:0000185)2.46703349
71positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling2.45735415
72positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.45530275
73regulation of type I interferon-mediated signaling pathway (GO:0060338)2.45405608
74regulation of superoxide anion generation (GO:0032928)2.44198867
75glucose 6-phosphate metabolic process (GO:0051156)2.42986671
76tolerance induction (GO:0002507)2.40998237
77cellular response to virus (GO:0098586)2.40367494
78positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.40296681
79negative regulation of myeloid cell apoptotic process (GO:0033033)2.40050585
80activation of Rac GTPase activity (GO:0032863)2.39870347
81regulation of apoptotic process involved in morphogenesis (GO:1902337)2.39052890
82GDP-mannose metabolic process (GO:0019673)2.39051434
83response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.38752995
84response to host immune response (GO:0052572)2.38752995
85negative regulation of cell size (GO:0045792)2.36545895
86T-helper 1 type immune response (GO:0042088)2.35024012
87positive regulation of blood vessel endothelial cell migration (GO:0043536)2.33841274
88viral protein processing (GO:0019082)2.33511634
89positive regulation of type 2 immune response (GO:0002830)2.29957070
90regulation of mast cell degranulation (GO:0043304)2.29579837
91regulation of podosome assembly (GO:0071801)2.29106537
92regulation of myeloid leukocyte mediated immunity (GO:0002886)2.27475430
93negative regulation of cytokine production involved in immune response (GO:0002719)2.25296356
94positive regulation of keratinocyte differentiation (GO:0045618)2.24648821
95glycosphingolipid catabolic process (GO:0046479)2.24625886
96focal adhesion assembly (GO:0048041)2.23783255
97cell-substrate adherens junction assembly (GO:0007045)2.23783255
98interferon-gamma-mediated signaling pathway (GO:0060333)2.23465870
99regulation of viral release from host cell (GO:1902186)2.23425451
100G-protein coupled purinergic receptor signaling pathway (GO:0035588)2.22845327

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1VDR_21846776_ChIP-Seq_THP-1_Human2.87276809
2MYC_22102868_ChIP-Seq_BL_Human2.65083743
3THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.61039236
4NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.60770596
5LXR_22292898_ChIP-Seq_THP-1_Human2.58508921
6TP63_17297297_ChIP-ChIP_HaCaT_Human2.51182291
7ELK3_25401928_ChIP-Seq_HUVEC_Human2.37538768
8TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.36463605
9TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.21736590
10RACK7_27058665_Chip-Seq_MCF-7_Human2.17816045
11NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.17558639
12RARG_19884340_ChIP-ChIP_MEFs_Mouse2.17483487
13EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.13279604
14KDM2B_26808549_Chip-Seq_SUP-B15_Human2.10977223
15KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.08379810
16PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.97139123
17TCF7_22412390_ChIP-Seq_EML_Mouse1.90275570
18KDM2B_26808549_Chip-Seq_DND41_Human1.89204093
19EGR1_19374776_ChIP-ChIP_THP-1_Human1.87051597
20VDR_24763502_ChIP-Seq_THP-1_Human1.83038718
21MAF_26560356_Chip-Seq_TH1_Human1.69727416
22ZNF263_19887448_ChIP-Seq_K562_Human1.69379863
23ESR2_21235772_ChIP-Seq_MCF-7_Human1.63942251
24DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.57503134
25TET1_21451524_ChIP-Seq_MESCs_Mouse1.56204612
26MAF_26560356_Chip-Seq_TH2_Human1.55408996
27E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.54625128
28RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.48948177
29NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.48224613
30SRY_22984422_ChIP-ChIP_TESTIS_Rat1.47287130
31IRF8_22096565_ChIP-ChIP_GC-B_Human1.44864981
32HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.44303967
33KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.43662056
34RUNX1_22412390_ChIP-Seq_EML_Mouse1.43661460
35SA1_27219007_Chip-Seq_ERYTHROID_Human1.43483100
36RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.41085403
37CTCF_27219007_Chip-Seq_ERYTHROID_Human1.41077691
38UTX_26944678_Chip-Seq_JUKART_Human1.39196904
39P68_20966046_ChIP-Seq_HELA_Human1.39136154
40MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.38201895
41BRD4_27068464_Chip-Seq_AML-cells_Mouse1.37841021
42KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.37530093
43SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.37308693
44SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.35343407
45STAT4_19710469_ChIP-ChIP_TH1__Mouse1.31495146
46ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.30563366
47KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.30284400
48PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.29865086
49KDM2B_26808549_Chip-Seq_K562_Human1.29623611
50UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.29542501
51ZFP281_18757296_ChIP-ChIP_E14_Mouse1.27600588
52CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.25802817
53KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.25642679
54TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.25353456
55RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.24131266
56GATA1_22383799_ChIP-Seq_G1ME_Mouse1.24100078
57SMC4_20622854_ChIP-Seq_HELA_Human1.23533017
58STAT6_21828071_ChIP-Seq_BEAS2B_Human1.23212650
59ATF3_27146783_Chip-Seq_COLON_Human1.21515919
60MYB_21317192_ChIP-Seq_ERMYB_Mouse1.20937484
61SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.20730443
62KDM2B_26808549_Chip-Seq_JURKAT_Human1.20576516
63EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.20170339
64PU.1_20513432_ChIP-Seq_Bcells_Mouse1.19852644
65TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.19693681
66CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.19262367
67TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.18484565
68TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.18402294
69KLF4_18555785_ChIP-Seq_MESCs_Mouse1.17082235
70CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.17016399
71ELF1_20517297_ChIP-Seq_JURKAT_Human1.16846877
72STAT3_1855785_ChIP-Seq_MESCs_Mouse1.16516502
73BCOR_27268052_Chip-Seq_Bcells_Human1.16474995
74CREB1_26743006_Chip-Seq_LNCaP_Human1.14830520
75P300_27058665_Chip-Seq_ZR-75-30cells_Human1.14370063
76BP1_19119308_ChIP-ChIP_Hs578T_Human1.12652398
77TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.12451962
78CLOCK_20551151_ChIP-Seq_293T_Human1.12192836
79BCL6_27268052_Chip-Seq_Bcells_Human1.11269835
80NCOR1_26117541_ChIP-Seq_K562_Human1.10672177
81SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.10157326
82NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.09654749
83TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.09468114
84CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.09466125
85SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.09272561
86SPI1_23127762_ChIP-Seq_K562_Human1.09157343
87CTCF_26484167_Chip-Seq_Bcells_Mouse1.08252869
88MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.08221903
89SPI1_23547873_ChIP-Seq_NB4_Human1.08171259
90CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.07493857
91PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.06896366
92EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.06524853
93GATA1_19941827_ChIP-Seq_MEL_Mouse1.05691103
94IRF8_21731497_ChIP-ChIP_J774_Mouse1.05522674
95DNAJC2_21179169_ChIP-ChIP_NT2_Human1.05190346
96CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.04572228
97FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.04365352
98HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.03891212
99SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.03639185
100SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.03198846

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005058_abnormal_lysosome_morphology3.72483782
2MP0003303_peritoneal_inflammation3.66915807
3MP0005451_abnormal_body_composition3.41986584
4MP0003436_decreased_susceptibility_to3.27704027
5MP0003705_abnormal_hypodermis_morpholog3.10945069
6MP0008260_abnormal_autophagy2.79913643
7MP0003300_gastrointestinal_ulcer2.71026014
8MP0009840_abnormal_foam_cell2.61802767
9MP0004510_myositis2.51558963
10MP0003191_abnormal_cellular_cholesterol2.47372349
11MP0005000_abnormal_immune_tolerance2.07516026
12MP0000685_abnormal_immune_system2.03268906
13MP0003172_abnormal_lysosome_physiology2.00416904
14MP0001835_abnormal_antigen_presentation1.97587281
15MP0001790_abnormal_immune_system1.95852972
16MP0005387_immune_system_phenotype1.95852972
17MP0003453_abnormal_keratinocyte_physiol1.95104625
18MP0001873_stomach_inflammation1.92035336
19MP0002148_abnormal_hypersensitivity_rea1.91420490
20MP0005025_abnormal_response_to1.89882800
21MP0002419_abnormal_innate_immunity1.87499411
22MP0004947_skin_inflammation1.81356269
23MP0000858_altered_metastatic_potential1.80075768
24MP0009333_abnormal_splenocyte_physiolog1.79181365
25MP0009278_abnormal_bone_marrow1.75440258
26MP0009785_altered_susceptibility_to1.70811636
27MP0003763_abnormal_thymus_physiology1.70771353
28MP0010155_abnormal_intestine_physiology1.68610092
29MP0001533_abnormal_skeleton_physiology1.65440176
30MP0004858_abnormal_nervous_system1.63620101
31MP0005076_abnormal_cell_differentiation1.60652364
32MP0003075_altered_response_to1.59354647
33MP0002723_abnormal_immune_serum1.57417028
34MP0001849_ear_inflammation1.56764783
35MP0001800_abnormal_humoral_immune1.52009851
36MP0002452_abnormal_antigen_presenting1.51856008
37MP0006082_CNS_inflammation1.50157270
38MP0005464_abnormal_platelet_physiology1.50092197
39MP0003183_abnormal_peptide_metabolism1.48910999
40MP0003566_abnormal_cell_adhesion1.47824383
41MP0002420_abnormal_adaptive_immunity1.47652354
42MP0003724_increased_susceptibility_to1.47257360
43MP0002877_abnormal_melanocyte_morpholog1.47246903
44MP0001819_abnormal_immune_cell1.46994968
45MP0004185_abnormal_adipocyte_glucose1.46827905
46MP0002796_impaired_skin_barrier1.38996286
47MP0000490_abnormal_crypts_of1.35968430
48MP0000343_altered_response_to1.35892595
49MP0010234_abnormal_vibrissa_follicle1.34880055
50MP0005671_abnormal_response_to1.34327865
51MP0003329_amyloid_beta_deposits1.31677913
52MP0002998_abnormal_bone_remodeling1.31200525
53MP0003806_abnormal_nucleotide_metabolis1.31029011
54MP0001845_abnormal_inflammatory_respons1.30064010
55MP0000604_amyloidosis1.24320366
56MP0008438_abnormal_cutaneous_collagen1.23580866
57MP0002405_respiratory_system_inflammati1.23256205
58MP0004264_abnormal_extraembryonic_tissu1.23052580
59MP0002132_abnormal_respiratory_system1.21535600
60MP0002398_abnormal_bone_marrow1.19700550
61MP0000716_abnormal_immune_system1.15027075
62MP0005501_abnormal_skin_physiology1.10901278
63MP0008469_abnormal_protein_level1.10563996
64MP0003866_abnormal_defecation1.05454182
65MP0005023_abnormal_wound_healing1.05367852
66MP0002429_abnormal_blood_cell1.05281852
67MP0003091_abnormal_cell_migration1.04427335
68MP0004381_abnormal_hair_follicle1.03216096
69MP0003448_altered_tumor_morphology0.99823294
70MP0005390_skeleton_phenotype0.99430842
71MP0005310_abnormal_salivary_gland0.98271615
72MP0004233_abnormal_muscle_weight0.96347606
73MP0005666_abnormal_adipose_tissue0.95900369
74MP0002722_abnormal_immune_system0.95881983
75MP0005166_decreased_susceptibility_to0.95319380
76MP0002089_abnormal_postnatal_growth/wei0.94229140
77MP0000678_abnormal_parathyroid_gland0.93418058
78MP0003279_aneurysm0.91318021
79MP0005257_abnormal_intraocular_pressure0.91024061
80MP0001348_abnormal_lacrimal_gland0.89263229
81MP0000750_abnormal_muscle_regeneration0.89165438
82MP0000703_abnormal_thymus_morphology0.89089584
83MP0002139_abnormal_hepatobiliary_system0.86184878
84MP0000689_abnormal_spleen_morphology0.84908051
85MP0005375_adipose_tissue_phenotype0.82975506
86MP0001663_abnormal_digestive_system0.82607636
87MP0003656_abnormal_erythrocyte_physiolo0.81434170
88MP0003795_abnormal_bone_structure0.81102891
89MP0008874_decreased_physiological_sensi0.79820897
90MP0001853_heart_inflammation0.79707498
91MP0001216_abnormal_epidermal_layer0.79695889
92MP0002254_reproductive_system_inflammat0.79387984
93MP0001851_eye_inflammation0.78925492
94MP0002933_joint_inflammation0.77067162
95MP0004808_abnormal_hematopoietic_stem0.75597796
96MP0009931_abnormal_skin_appearance0.74849693
97MP0002277_abnormal_respiratory_mucosa0.73249863
98MP0002396_abnormal_hematopoietic_system0.72265613
99MP0002060_abnormal_skin_morphology0.68032809
100MP0005621_abnormal_cell_physiology0.67747598

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of liposaccharide metabolism (HP:0010968)3.72874163
2Abnormality of glycosphingolipid metabolism (HP:0004343)3.72874163
3Abnormality of glycolipid metabolism (HP:0010969)3.72874163
4Eczematoid dermatitis (HP:0000976)3.58172591
5Vertebral compression fractures (HP:0002953)3.48875870
6Abnormality of macrophages (HP:0004311)3.32756451
7Distal lower limb muscle weakness (HP:0009053)3.09578242
8Dysostosis multiplex (HP:0000943)2.97837867
9Loss of speech (HP:0002371)2.90793046
10Axonal loss (HP:0003447)2.87253523
11Recurrent abscess formation (HP:0002722)2.66431089
12Increased cerebral lipofuscin (HP:0011813)2.58448825
13Recurrent bacterial skin infections (HP:0005406)2.55871062
14Protrusio acetabuli (HP:0003179)2.54914986
15Cholecystitis (HP:0001082)2.45337474
16Abnormal gallbladder physiology (HP:0012438)2.45337474
17Thin bony cortex (HP:0002753)2.43764600
18Cellulitis (HP:0100658)2.41091078
19Gastrointestinal stroma tumor (HP:0100723)2.39057170
20Hyperparathyroidism (HP:0000843)2.39031701
21Mediastinal lymphadenopathy (HP:0100721)2.34627354
22Ragged-red muscle fibers (HP:0003200)2.33014601
23Chronic obstructive pulmonary disease (HP:0006510)2.31111612
24Obstructive lung disease (HP:0006536)2.31111612
25Purpura (HP:0000979)2.29322135
26Achilles tendon contracture (HP:0001771)2.28652421
27Hyperacusis (HP:0010780)2.27930706
28Abnormality of glycosaminoglycan metabolism (HP:0004371)2.27637391
29Abnormality of mucopolysaccharide metabolism (HP:0011020)2.27637391
30Abnormality of polysaccharide metabolism (HP:0011012)2.27637391
31Increased serum ferritin (HP:0003281)2.21366123
32Neuronal loss in central nervous system (HP:0002529)2.19645686
33Gastrointestinal infarctions (HP:0005244)2.18046637
34Flat acetabular roof (HP:0003180)2.17862554
35J-shaped sella turcica (HP:0002680)2.15413739
36Premature rupture of membranes (HP:0001788)2.14445588
37Mucopolysacchariduria (HP:0008155)2.14087563
38Urinary glycosaminoglycan excretion (HP:0003541)2.14087563
39Polygenic inheritance (HP:0010982)2.12998322
40Myositis (HP:0100614)2.12390348
41Increased IgE level (HP:0003212)2.12259322
42Petechiae (HP:0000967)2.11214356
43Abnormality of the Achilles tendon (HP:0005109)2.10733311
44Increased neuronal autofluorescent lipopigment (HP:0002074)2.09982354
45Upper limb amyotrophy (HP:0009129)2.08104679
46Distal upper limb amyotrophy (HP:0007149)2.08104679
47Increased connective tissue (HP:0009025)2.05100173
48Nuclear cataract (HP:0100018)2.04743462
49Centrally nucleated skeletal muscle fibers (HP:0003687)2.01862469
50Distal lower limb amyotrophy (HP:0008944)2.01856557
51Deep venous thrombosis (HP:0002625)2.00393211
52Abnormality of the thoracic spine (HP:0100711)1.99795735
53Long palpebral fissure (HP:0000637)1.97771599
54Bone pain (HP:0002653)1.97199158
55Interstitial pulmonary disease (HP:0006530)1.96343937
56Obstructive sleep apnea (HP:0002870)1.95164856
57Hypertensive crisis (HP:0100735)1.95149469
58Supranuclear gaze palsy (HP:0000605)1.95146376
59Segmental peripheral demyelination/remyelination (HP:0003481)1.94948509
60Cervical subluxation (HP:0003308)1.94047037
61Orchitis (HP:0100796)1.93020090
62Urticaria (HP:0001025)1.92316386
63Thoracic kyphosis (HP:0002942)1.90389018
64Emphysema (HP:0002097)1.89038518
65Meningitis (HP:0001287)1.88255319
66Metaphyseal cupping (HP:0003021)1.86540664
67Prolonged neonatal jaundice (HP:0006579)1.85354835
68Progressive neurologic deterioration (HP:0002344)1.83573240
69Progressive muscle weakness (HP:0003323)1.83269797
70Broad face (HP:0000283)1.83190309
71Hepatosplenomegaly (HP:0001433)1.83034671
72Cerebral inclusion bodies (HP:0100314)1.81881699
73Gastrointestinal inflammation (HP:0004386)1.81329438
74Recurrent gram-negative bacterial infections (HP:0005420)1.81137584
75Abnormality of the nasal mucosa (HP:0000433)1.80701252
76Trismus (HP:0000211)1.80471718
77Colitis (HP:0002583)1.75542925
78Generalized amyotrophy (HP:0003700)1.75449619
79Pathologic fracture (HP:0002756)1.75227409
80Amyloidosis (HP:0011034)1.75209991
81Gingivitis (HP:0000230)1.74592701
82Diminished motivation (HP:0000745)1.72825941
83Apathy (HP:0000741)1.72809188
84Hypercortisolism (HP:0001578)1.72681215
85Asymmetry of the thorax (HP:0001555)1.72367163
86Vasculitis (HP:0002633)1.70821398
87Nasal polyposis (HP:0100582)1.70539556
88Myopathic facies (HP:0002058)1.69645216
89Systemic lupus erythematosus (HP:0002725)1.69235723
90Abdominal distention (HP:0003270)1.69186336
91Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.68339141
92Growth hormone excess (HP:0000845)1.67226709
93Recurrent skin infections (HP:0001581)1.66999699
94Malnutrition (HP:0004395)1.66881736
95Blue sclerae (HP:0000592)1.66465690
96Progressive external ophthalmoplegia (HP:0000590)1.65717152
97Cupped ribs (HP:0000887)1.65670527
98Bulbar palsy (HP:0001283)1.65378603
99Dilatation of the ascending aorta (HP:0005111)1.64818502
100Neurofibrillary tangles (HP:0002185)1.64727283

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB34.70951669
2ERN13.27501005
3PRPF4B3.12542792
4NME23.04420993
5IRAK32.96491640
6SMG12.83375278
7SIK12.70120456
8RIPK42.25102020
9TAOK21.96141202
10MAP4K11.92201516
11ICK1.85364199
12TESK11.81855101
13MAP2K31.80370147
14EPHA21.74090513
15MAP3K131.71874627
16IRAK41.69768761
17SIK31.67250839
18MAP3K111.65335752
19PKN21.63797612
20TAOK11.60985138
21TESK21.58621657
22TBK11.56394765
23ARAF1.55780724
24MAP3K141.52004638
25CDK121.50204340
26EEF2K1.43312887
27MAP3K31.41014592
28KSR21.33037395
29FGFR41.32986236
30PAK41.27084889
31EPHB11.21386648
32TYK21.15801446
33PRKD21.15276618
34GRK61.13999886
35RIPK11.13566148
36PDPK11.09739090
37MAP3K11.08434221
38MAP2K21.03997091
39PTK60.96655000
40IRAK20.96496561
41ZAP700.96116910
42RPS6KB20.93640412
43MAPKAPK30.92814248
44SIK20.90766888
45SCYL20.89202631
46MOS0.88137744
47TTN0.87823372
48MARK20.84601218
49LRRK20.83474002
50BRAF0.82960174
51CDC42BPA0.82796243
52CSK0.82099677
53CDK190.79422756
54PIM20.78546497
55TNK20.78314037
56JAK30.75516657
57PRKD30.75241148
58IKBKB0.74415516
59HIPK20.73284511
60LMTK20.72626988
61PDK10.72132199
62IKBKE0.70216667
63ILK0.70067487
64BLK0.69483548
65FGR0.68790774
66RPS6KC10.68000601
67RPS6KL10.68000601
68MAP3K100.64772167
69PDGFRA0.63723022
70MAP3K80.62131472
71RPS6KA20.58426565
72CSF1R0.57501235
73TYRO30.55414386
74BMX0.54195592
75BTK0.53604024
76DDR20.52871533
77RET0.51507051
78HCK0.49437320
79PTK20.48962589
80MAP3K90.48319288
81CAMKK10.47827297
82MATK0.47452320
83PRKG20.47191010
84MTOR0.46022750
85RPS6KA60.44681915
86MAPK110.44652462
87MAPKAPK20.44494583
88CHUK0.44207882
89ABL20.43783194
90LATS20.42764190
91LIMK10.42518200
92DYRK1B0.40448188
93FES0.39481445
94STK380.37895584
95CDK40.36250343
96JAK20.35869237
97CDK70.35125938
98DAPK30.34180469
99MAPK40.33394714
100DMPK0.33188270

Predicted pathways (KEGG)

RankGene SetZ-score
1Other glycan degradation_Homo sapiens_hsa005112.88761234
2Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.42829037
3Osteoclast differentiation_Homo sapiens_hsa043802.17173283
4B cell receptor signaling pathway_Homo sapiens_hsa046622.13547420
5Acute myeloid leukemia_Homo sapiens_hsa052212.08361483
6Toll-like receptor signaling pathway_Homo sapiens_hsa046201.94314525
7Leishmaniasis_Homo sapiens_hsa051401.88675851
8Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.86331423
9Glycosaminoglycan degradation_Homo sapiens_hsa005311.79595481
10Chronic myeloid leukemia_Homo sapiens_hsa052201.73397357
11Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.71207504
12VEGF signaling pathway_Homo sapiens_hsa043701.66458756
13Lysosome_Homo sapiens_hsa041421.62376088
14Pentose phosphate pathway_Homo sapiens_hsa000301.54129720
15Sulfur relay system_Homo sapiens_hsa041221.52954161
16Non-small cell lung cancer_Homo sapiens_hsa052231.52869052
17Prion diseases_Homo sapiens_hsa050201.49650831
18Bladder cancer_Homo sapiens_hsa052191.49425277
19Fructose and mannose metabolism_Homo sapiens_hsa000511.44478181
20NF-kappa B signaling pathway_Homo sapiens_hsa040641.40890745
21Toxoplasmosis_Homo sapiens_hsa051451.39934577
22Pancreatic cancer_Homo sapiens_hsa052121.39189252
23Tuberculosis_Homo sapiens_hsa051521.38895466
24Influenza A_Homo sapiens_hsa051641.37709348
25TNF signaling pathway_Homo sapiens_hsa046681.36982598
26Hepatitis C_Homo sapiens_hsa051601.36103654
27Allograft rejection_Homo sapiens_hsa053301.35630934
28Shigellosis_Homo sapiens_hsa051311.29991878
29Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.29571063
30Vibrio cholerae infection_Homo sapiens_hsa051101.22230729
31Salmonella infection_Homo sapiens_hsa051321.21696216
32Central carbon metabolism in cancer_Homo sapiens_hsa052301.21532930
33T cell receptor signaling pathway_Homo sapiens_hsa046601.20928423
34Neurotrophin signaling pathway_Homo sapiens_hsa047221.19137622
35Hepatitis B_Homo sapiens_hsa051611.18628324
36Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.18159243
37AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.16280437
38RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.15544686
39Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.14496014
40Measles_Homo sapiens_hsa051621.13608814
41Autoimmune thyroid disease_Homo sapiens_hsa053201.13232790
42Renal cell carcinoma_Homo sapiens_hsa052111.12948851
43Apoptosis_Homo sapiens_hsa042101.10283003
44Malaria_Homo sapiens_hsa051441.09598660
45Galactose metabolism_Homo sapiens_hsa000521.09330046
46Notch signaling pathway_Homo sapiens_hsa043301.09278065
47Viral myocarditis_Homo sapiens_hsa054161.08979263
48Legionellosis_Homo sapiens_hsa051341.06878027
49Graft-versus-host disease_Homo sapiens_hsa053321.04325749
50Endocytosis_Homo sapiens_hsa041441.01954687
51Staphylococcus aureus infection_Homo sapiens_hsa051501.00053768
52Antigen processing and presentation_Homo sapiens_hsa046120.99669827
53Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.99205619
54Herpes simplex infection_Homo sapiens_hsa051680.98510055
55Leukocyte transendothelial migration_Homo sapiens_hsa046700.98163979
56Chemokine signaling pathway_Homo sapiens_hsa040620.95524299
57Endometrial cancer_Homo sapiens_hsa052130.95325569
58Sphingolipid signaling pathway_Homo sapiens_hsa040710.92909973
59Rheumatoid arthritis_Homo sapiens_hsa053230.92784344
60Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.91676567
61Epstein-Barr virus infection_Homo sapiens_hsa051690.90471715
62mTOR signaling pathway_Homo sapiens_hsa041500.88142602
63Prolactin signaling pathway_Homo sapiens_hsa049170.86460632
64Amoebiasis_Homo sapiens_hsa051460.85651842
65Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.85481954
66Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.85093170
67Pertussis_Homo sapiens_hsa051330.83608016
68Insulin signaling pathway_Homo sapiens_hsa049100.83287061
69Intestinal immune network for IgA production_Homo sapiens_hsa046720.82949257
70HTLV-I infection_Homo sapiens_hsa051660.82760238
71Thyroid cancer_Homo sapiens_hsa052160.81706568
72Glioma_Homo sapiens_hsa052140.80440929
73Phagosome_Homo sapiens_hsa041450.80092377
74Ribosome_Homo sapiens_hsa030100.79787496
75Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.79246172
76Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.78817443
77Adipocytokine signaling pathway_Homo sapiens_hsa049200.78334389
78NOD-like receptor signaling pathway_Homo sapiens_hsa046210.76771753
79ErbB signaling pathway_Homo sapiens_hsa040120.76623993
80HIF-1 signaling pathway_Homo sapiens_hsa040660.74703776
81Estrogen signaling pathway_Homo sapiens_hsa049150.72533471
82Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.70892779
83Type I diabetes mellitus_Homo sapiens_hsa049400.69057924
84Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.68513343
85Cyanoamino acid metabolism_Homo sapiens_hsa004600.68438469
86Biosynthesis of amino acids_Homo sapiens_hsa012300.64679437
87Primary immunodeficiency_Homo sapiens_hsa053400.64144867
88GnRH signaling pathway_Homo sapiens_hsa049120.63917088
89Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.63872126
90African trypanosomiasis_Homo sapiens_hsa051430.63869378
912-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.62988705
92Viral carcinogenesis_Homo sapiens_hsa052030.60299635
93Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.59424511
94Small cell lung cancer_Homo sapiens_hsa052220.59056445
95Longevity regulating pathway - mammal_Homo sapiens_hsa042110.58790256
96Prostate cancer_Homo sapiens_hsa052150.57955469
97Choline metabolism in cancer_Homo sapiens_hsa052310.56736194
98Phospholipase D signaling pathway_Homo sapiens_hsa040720.56175394
99Insulin resistance_Homo sapiens_hsa049310.55881782
100Proteoglycans in cancer_Homo sapiens_hsa052050.54283193

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