INO80C

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1indole-containing compound catabolic process (GO:0042436)5.37680271
2indolalkylamine catabolic process (GO:0046218)5.37680271
3tryptophan catabolic process (GO:0006569)5.37680271
4kynurenine metabolic process (GO:0070189)5.29618933
5indolalkylamine metabolic process (GO:0006586)5.01342513
6ribosomal small subunit assembly (GO:0000028)5.00563346
7tryptophan metabolic process (GO:0006568)4.70073031
8formation of translation preinitiation complex (GO:0001731)4.31668311
9detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)4.23960558
10behavioral response to nicotine (GO:0035095)4.22129209
11maturation of SSU-rRNA (GO:0030490)4.18345690
12signal peptide processing (GO:0006465)4.15245679
13fucose catabolic process (GO:0019317)4.07289161
14L-fucose metabolic process (GO:0042354)4.07289161
15L-fucose catabolic process (GO:0042355)4.07289161
16proteasome assembly (GO:0043248)3.89997974
17translational termination (GO:0006415)3.84265332
18viral transcription (GO:0019083)3.83567345
19DNA strand elongation involved in DNA replication (GO:0006271)3.77744198
20purine nucleobase biosynthetic process (GO:0009113)3.77024407
21DNA deamination (GO:0045006)3.76501636
22sulfation (GO:0051923)3.75786844
23nucleobase biosynthetic process (GO:0046112)3.75139159
24negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.67967384
25DNA strand elongation (GO:0022616)3.65415980
26ribosomal small subunit biogenesis (GO:0042274)3.65113941
27detection of light stimulus involved in sensory perception (GO:0050962)3.61530504
28detection of light stimulus involved in visual perception (GO:0050908)3.61530504
29neural tube formation (GO:0001841)3.59818272
30ribosome biogenesis (GO:0042254)3.59422101
31cellular biogenic amine catabolic process (GO:0042402)3.58578991
32amine catabolic process (GO:0009310)3.58578991
33regulation of hippo signaling (GO:0035330)3.57436169
34response to pheromone (GO:0019236)3.56429909
35regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.55501525
36telomere maintenance via semi-conservative replication (GO:0032201)3.52847012
37positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.52429799
38ribonucleoprotein complex biogenesis (GO:0022613)3.51389592
39anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.50926078
40indole-containing compound metabolic process (GO:0042430)3.50386735
41translational elongation (GO:0006414)3.50006180
42translational initiation (GO:0006413)3.46702093
43mitotic nuclear envelope disassembly (GO:0007077)3.44772809
44cellular ketone body metabolic process (GO:0046950)3.43590929
45DNA replication checkpoint (GO:0000076)3.42924584
46protein localization to kinetochore (GO:0034501)3.41918934
47DNA replication initiation (GO:0006270)3.39368953
48protein localization to chromosome, centromeric region (GO:0071459)3.38676403
49negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.37751846
50negative regulation of ligase activity (GO:0051352)3.37751846
51ribosomal large subunit biogenesis (GO:0042273)3.36917509
52L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.36852984
53mitotic metaphase plate congression (GO:0007080)3.35418725
54ribosome assembly (GO:0042255)3.34065234
55SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.32952195
56regulation of gene silencing by miRNA (GO:0060964)3.32217314
57regulation of gene silencing by RNA (GO:0060966)3.32217314
58regulation of posttranscriptional gene silencing (GO:0060147)3.32217314
59negative regulation of mast cell activation (GO:0033004)3.31357479
60cilium or flagellum-dependent cell motility (GO:0001539)3.30936092
61NAD biosynthetic process (GO:0009435)3.29573585
62photoreceptor cell maintenance (GO:0045494)3.26824581
63cotranslational protein targeting to membrane (GO:0006613)3.26201320
64regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.25700565
65behavioral response to ethanol (GO:0048149)3.23429328
66double-strand break repair via homologous recombination (GO:0000724)3.23157098
67recombinational repair (GO:0000725)3.23095282
68protein targeting to ER (GO:0045047)3.23031788
69nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.22574039
70reflex (GO:0060004)3.21836015
71DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.20054868
72telomere maintenance via recombination (GO:0000722)3.19667350
73transcription elongation from RNA polymerase III promoter (GO:0006385)3.18621151
74termination of RNA polymerase III transcription (GO:0006386)3.18621151
75CENP-A containing nucleosome assembly (GO:0034080)3.18152754
76antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.17709739
77benzene-containing compound metabolic process (GO:0042537)3.16531965
78intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.15637399
79signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.15637399
80membrane disassembly (GO:0030397)3.15351805
81nuclear envelope disassembly (GO:0051081)3.15351805
82water-soluble vitamin biosynthetic process (GO:0042364)3.13668537
83signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.12996888
84signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.12996888
85signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.12996888
86rRNA processing (GO:0006364)3.12121013
87positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.11300495
88regulation of cellular amino acid metabolic process (GO:0006521)3.11115907
89piRNA metabolic process (GO:0034587)3.09199019
90cellular protein complex disassembly (GO:0043624)3.08869063
91ketone body metabolic process (GO:1902224)3.08331944
92antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.07896541
93protein localization to endoplasmic reticulum (GO:0070972)3.07496727
94kinetochore organization (GO:0051383)3.06162049
95DNA unwinding involved in DNA replication (GO:0006268)3.06093438
96regulation of spindle organization (GO:0090224)3.05843034
97signal transduction involved in DNA damage checkpoint (GO:0072422)3.05469353
98signal transduction involved in DNA integrity checkpoint (GO:0072401)3.05469353
99establishment of protein localization to endoplasmic reticulum (GO:0072599)3.04884125
100protein K11-linked deubiquitination (GO:0035871)3.04548823
101signal transduction involved in cell cycle checkpoint (GO:0072395)3.03009758
102rRNA metabolic process (GO:0016072)3.01723958
103positive regulation of ligase activity (GO:0051351)3.01718294
104chromatin remodeling at centromere (GO:0031055)3.01450102
105viral life cycle (GO:0019058)3.00504519
106aromatic amino acid family catabolic process (GO:0009074)2.99961856
107pseudouridine synthesis (GO:0001522)2.98878982
108respiratory chain complex IV assembly (GO:0008535)2.98636153
109cell cycle G1/S phase transition (GO:0044843)2.97295769
110G1/S transition of mitotic cell cycle (GO:0000082)2.97295769
111mitotic recombination (GO:0006312)2.96095562
112mitochondrial respiratory chain complex I assembly (GO:0032981)2.95745092
113NADH dehydrogenase complex assembly (GO:0010257)2.95745092
114mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.95745092
115auditory receptor cell stereocilium organization (GO:0060088)2.92224658
116L-methionine salvage (GO:0071267)2.91238958
117L-methionine biosynthetic process (GO:0071265)2.91238958
118amino acid salvage (GO:0043102)2.91238958
119protein complex biogenesis (GO:0070271)2.91119462
120spliceosomal snRNP assembly (GO:0000387)2.88907370
121translation (GO:0006412)2.88904503
122IMP biosynthetic process (GO:0006188)2.88864440
123replication fork processing (GO:0031297)2.87836840
124tachykinin receptor signaling pathway (GO:0007217)2.87751538
125attachment of spindle microtubules to kinetochore (GO:0008608)2.87322040
126kinetochore assembly (GO:0051382)2.87253635
127monoubiquitinated protein deubiquitination (GO:0035520)2.86769548
128RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.85604366
129regulation of ubiquitin-protein transferase activity (GO:0051438)2.84352945
130DNA replication-independent nucleosome assembly (GO:0006336)2.83581783
131DNA replication-independent nucleosome organization (GO:0034724)2.83581783
132positive regulation of developmental pigmentation (GO:0048087)2.82110310
133reciprocal meiotic recombination (GO:0007131)2.82076723
134reciprocal DNA recombination (GO:0035825)2.82076723
135IMP metabolic process (GO:0046040)2.80998337
136cellular component biogenesis (GO:0044085)2.80663279
137regulation of sarcomere organization (GO:0060297)2.80275482
138deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.80190750
139platelet dense granule organization (GO:0060155)2.79417449
140DNA double-strand break processing (GO:0000729)2.78765649
141negative regulation of cytosolic calcium ion concentration (GO:0051481)2.77514527
142regulation of ligase activity (GO:0051340)2.77488224
143histone exchange (GO:0043486)2.76170288
144protein K63-linked deubiquitination (GO:0070536)2.75967622
145rRNA modification (GO:0000154)2.75415225
146regulation of establishment of cell polarity (GO:2000114)2.74475218
147DNA demethylation (GO:0080111)2.73311403
148metaphase plate congression (GO:0051310)2.72882938
149mitochondrial respiratory chain complex assembly (GO:0033108)2.72397559
150viral mRNA export from host cell nucleus (GO:0046784)2.72224637
151protein complex disassembly (GO:0043241)2.71345742
152rRNA catabolic process (GO:0016075)2.70045945
153regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.69952349
154termination of RNA polymerase I transcription (GO:0006363)2.69550225
155epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.68887444
156aromatic amino acid family metabolic process (GO:0009072)2.68061926
157telomere maintenance via telomere lengthening (GO:0010833)2.68059316
158protein prenylation (GO:0018342)2.67853966
159prenylation (GO:0097354)2.67853966
160regulation of memory T cell differentiation (GO:0043380)2.67760831
161cytochrome complex assembly (GO:0017004)2.67729751
162negative regulation of calcium ion transport into cytosol (GO:0010523)2.67383252
163mitochondrial DNA replication (GO:0006264)2.66861954
164oxidative demethylation (GO:0070989)2.66309682
165protein K48-linked deubiquitination (GO:0071108)2.65344394
166methionine biosynthetic process (GO:0009086)2.65266305
167establishment of chromosome localization (GO:0051303)2.63356336
1687-methylguanosine mRNA capping (GO:0006370)2.63293062
169snRNA transcription (GO:0009301)2.62693907
170DNA methylation involved in gamete generation (GO:0043046)2.62614586
171multicellular organism reproduction (GO:0032504)2.61728465
172positive regulation of cell cycle arrest (GO:0071158)2.61429663
173axoneme assembly (GO:0035082)2.60972937
174nuclear-transcribed mRNA catabolic process (GO:0000956)2.59159829
175transcription elongation from RNA polymerase I promoter (GO:0006362)2.58948024
176mitotic sister chromatid segregation (GO:0000070)2.58646024
177RNA capping (GO:0036260)2.57897715
1787-methylguanosine RNA capping (GO:0009452)2.57897715
179macromolecular complex disassembly (GO:0032984)2.57739575
180regulation of nuclear cell cycle DNA replication (GO:0033262)2.57428891
181male meiosis I (GO:0007141)2.55643458
182positive regulation of insulin-like growth factor receptor signaling pathway (GO:0043568)2.55421776
183negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.55234397
184negative regulation of translation, ncRNA-mediated (GO:0040033)2.55234397
185regulation of translation, ncRNA-mediated (GO:0045974)2.55234397
186nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.54114053
187serotonin metabolic process (GO:0042428)2.54049785
188thyroid hormone metabolic process (GO:0042403)2.53753110
189dopamine transport (GO:0015872)2.53571601
190retinal cone cell development (GO:0046549)2.51948504
191regulation of action potential (GO:0098900)2.51158511
192negative regulation of DNA-dependent DNA replication (GO:2000104)2.51095193
193tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.51042682
194RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.51042682
195cellular response to ATP (GO:0071318)2.50982240
196preassembly of GPI anchor in ER membrane (GO:0016254)2.50942377
197detection of mechanical stimulus involved in sensory perception (GO:0050974)2.49859170
198positive regulation of fatty acid transport (GO:2000193)2.49362816

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.05942956
2EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.79039733
3VDR_22108803_ChIP-Seq_LS180_Human3.71324940
4MYC_18555785_ChIP-Seq_MESCs_Mouse3.65435516
5ZNF274_21170338_ChIP-Seq_K562_Hela3.44593704
6KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.09316309
7GBX2_23144817_ChIP-Seq_PC3_Human3.08893171
8EST1_17652178_ChIP-ChIP_JURKAT_Human3.07625410
9GABP_17652178_ChIP-ChIP_JURKAT_Human3.01914459
10FOXM1_23109430_ChIP-Seq_U2OS_Human3.01121130
11E2F4_17652178_ChIP-ChIP_JURKAT_Human3.00926729
12IGF1R_20145208_ChIP-Seq_DFB_Human2.95239407
13JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.92713089
14ETS1_20019798_ChIP-Seq_JURKAT_Human2.82441614
15CREB1_15753290_ChIP-ChIP_HEK293T_Human2.81467516
16E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.79495928
17GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.78954631
18MYC_18358816_ChIP-ChIP_MESCs_Mouse2.58320871
19FLI1_27457419_Chip-Seq_LIVER_Mouse2.57316840
20NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.54894664
21ELF1_17652178_ChIP-ChIP_JURKAT_Human2.53096970
22ZFP57_27257070_Chip-Seq_ESCs_Mouse2.52460762
23MYC_19079543_ChIP-ChIP_MESCs_Mouse2.49476653
24FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.47041140
25MYC_19030024_ChIP-ChIP_MESCs_Mouse2.45634469
26MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.40017100
27POU3F2_20337985_ChIP-ChIP_501MEL_Human2.38095810
28* VDR_23849224_ChIP-Seq_CD4+_Human2.37244319
29CTBP2_25329375_ChIP-Seq_LNCAP_Human2.28724231
30TAF15_26573619_Chip-Seq_HEK293_Human2.27175673
31GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.26453531
32EWS_26573619_Chip-Seq_HEK293_Human2.19202206
33SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.18477223
34CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.11186735
35CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.10727899
36CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.10009898
37P300_19829295_ChIP-Seq_ESCs_Human2.09172742
38FUS_26573619_Chip-Seq_HEK293_Human2.06159039
39XRN2_22483619_ChIP-Seq_HELA_Human2.04489193
40HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.02855981
41EZH2_22144423_ChIP-Seq_EOC_Human2.00524249
42PCGF2_27294783_Chip-Seq_ESCs_Mouse2.00165889
43ER_23166858_ChIP-Seq_MCF-7_Human2.00069613
44AR_21909140_ChIP-Seq_LNCAP_Human1.99466152
45CTBP1_25329375_ChIP-Seq_LNCAP_Human1.97591973
46NELFA_20434984_ChIP-Seq_ESCs_Mouse1.94937826
47* FOXP3_21729870_ChIP-Seq_TREG_Human1.92299219
48HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.91111774
49SALL1_21062744_ChIP-ChIP_HESCs_Human1.90413669
50SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.87882246
51* GABP_19822575_ChIP-Seq_HepG2_Human1.86533490
52EGR1_19374776_ChIP-ChIP_THP-1_Human1.86166648
53* DCP1A_22483619_ChIP-Seq_HELA_Human1.85251389
54BCAT_22108803_ChIP-Seq_LS180_Human1.82994035
55* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.82312703
56* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.81533558
57E2F1_18555785_ChIP-Seq_MESCs_Mouse1.77723115
58ELK1_19687146_ChIP-ChIP_HELA_Human1.77376983
59FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.76490053
60PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.75389588
61* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.74057464
62EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.72534016
63HOXB4_20404135_ChIP-ChIP_EML_Mouse1.71444555
64SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.71373642
65UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.71209893
66SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.69881730
67* STAT3_23295773_ChIP-Seq_U87_Human1.68146535
68RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.65921346
69MYCN_18555785_ChIP-Seq_MESCs_Mouse1.61640250
70FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.61537255
71MYC_22102868_ChIP-Seq_BL_Human1.59744413
72CBP_20019798_ChIP-Seq_JUKART_Human1.59552656
73IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.59552656
74POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.59053766
75SRF_21415370_ChIP-Seq_HL-1_Mouse1.56737374
76ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.56529435
77* TTF2_22483619_ChIP-Seq_HELA_Human1.56239493
78SMAD4_21799915_ChIP-Seq_A2780_Human1.55972575
79PCGF2_27294783_Chip-Seq_NPCs_Mouse1.53198321
80IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.52988258
81THAP11_20581084_ChIP-Seq_MESCs_Mouse1.52714292
82MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.52650099
83* TCF4_23295773_ChIP-Seq_U87_Human1.51624231
84PIAS1_25552417_ChIP-Seq_VCAP_Human1.50778238
85SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.50571479
86SUZ12_27294783_Chip-Seq_NPCs_Mouse1.48052766
87SPI1_23547873_ChIP-Seq_NB4_Human1.47655304
88E2F1_21310950_ChIP-Seq_MCF-7_Human1.47404718
89MYB_21317192_ChIP-Seq_ERMYB_Mouse1.47398541
90EZH2_27294783_Chip-Seq_NPCs_Mouse1.45632126
91IRF1_19129219_ChIP-ChIP_H3396_Human1.45387306
92MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.44415416
93NFE2_27457419_Chip-Seq_LIVER_Mouse1.43345478
94NR3C1_21868756_ChIP-Seq_MCF10A_Human1.42532384
95POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.42427425
96TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.42427425
97PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.42170079
98IRF8_21731497_ChIP-ChIP_J774_Mouse1.41659443
99MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.41333586
100TP53_22573176_ChIP-Seq_HFKS_Human1.41277936
101FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.40634851
102NOTCH1_21737748_ChIP-Seq_TLL_Human1.40581724
103AR_25329375_ChIP-Seq_VCAP_Human1.40168045
104SOX2_19829295_ChIP-Seq_ESCs_Human1.39548120
105NANOG_19829295_ChIP-Seq_ESCs_Human1.39548120
106TCF4_22108803_ChIP-Seq_LS180_Human1.39476609
107PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.39442902
108ERG_20887958_ChIP-Seq_HPC-7_Mouse1.39397969
109SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.39196525
110MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.38958318
111YY1_21170310_ChIP-Seq_MESCs_Mouse1.37738374
112TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.36435676
113ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.35298371
114CIITA_25753668_ChIP-Seq_RAJI_Human1.34596595
115EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.31997755
116ZFX_18555785_ChIP-Seq_MESCs_Mouse1.30626989
117FOXA1_27270436_Chip-Seq_PROSTATE_Human1.29990556
118FOXA1_25329375_ChIP-Seq_VCAP_Human1.29990556
119KLF5_20875108_ChIP-Seq_MESCs_Mouse1.28987299
120KDM5A_27292631_Chip-Seq_BREAST_Human1.28831707
121AR_21572438_ChIP-Seq_LNCaP_Human1.28522014
122* SMAD3_21741376_ChIP-Seq_EPCs_Human1.28470018
123TOP2B_26459242_ChIP-Seq_MCF-7_Human1.27981494
124NANOG_18555785_ChIP-Seq_MESCs_Mouse1.27651755
125IRF8_22096565_ChIP-ChIP_GC-B_Human1.27440534
126YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.26652348
127PRDM14_20953172_ChIP-Seq_ESCs_Human1.25808666
128* SMAD4_21741376_ChIP-Seq_EPCs_Human1.25431744
129CRX_20693478_ChIP-Seq_RETINA_Mouse1.24792107
130FOXA1_21572438_ChIP-Seq_LNCaP_Human1.24295885
131EGR1_23403033_ChIP-Seq_LIVER_Mouse1.24263058
132CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.23920290
133RUNX2_22187159_ChIP-Seq_PCA_Human1.23109726
134FLI1_21867929_ChIP-Seq_TH2_Mouse1.22162673
135MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.22041253
136SCL_19346495_ChIP-Seq_HPC-7_Human1.19018500
137CDX2_22108803_ChIP-Seq_LS180_Human1.17811565
138AR_20517297_ChIP-Seq_VCAP_Human1.17703699
139STAT3_1855785_ChIP-Seq_MESCs_Mouse1.16780430
140* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.16005701
141MYC_18940864_ChIP-ChIP_HL60_Human1.15945209
142BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.15496852
143TFEB_21752829_ChIP-Seq_HELA_Human1.14100338
144GATA3_21878914_ChIP-Seq_MCF-7_Human1.13401325
145TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.12855386
146MYB_26560356_Chip-Seq_TH2_Human1.11133246
147NCOR_22424771_ChIP-Seq_293T_Human1.10468787
148SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.10256444
149VDR_21846776_ChIP-Seq_THP-1_Human1.10207750
150NANOG_18555785_Chip-Seq_ESCs_Mouse1.10119943
151PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.10056840
152STAT4_19710469_ChIP-ChIP_TH1__Mouse1.09646078
153EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.09084172
154GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.08846072
155OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.08808318
156KLF4_18555785_ChIP-Seq_MESCs_Mouse1.06956151
157HOXB7_26014856_ChIP-Seq_BT474_Human1.06340142
158GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.06020289
159OCT4_21477851_ChIP-Seq_ESCs_Mouse1.05667637
160GATA1_22383799_ChIP-Seq_G1ME_Mouse1.05504878
161E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.05141357
162SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.04956842
163TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.03921595
164AUTS2_25519132_ChIP-Seq_293T-REX_Human1.02650085
165BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.02336235
166ETV2_25802403_ChIP-Seq_MESCs_Mouse1.01694829
167MYB_26560356_Chip-Seq_TH1_Human1.01692852
168STAT3_18555785_Chip-Seq_ESCs_Mouse1.01571485
169P53_22387025_ChIP-Seq_ESCs_Mouse1.00388338
170TP53_16413492_ChIP-PET_HCT116_Human1.00184100
171E2F1_18555785_Chip-Seq_ESCs_Mouse0.98822848
172CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.98539507
173RUNX1_22412390_ChIP-Seq_EML_Mouse0.98171516
174TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.97886276
175PADI4_21655091_ChIP-ChIP_MCF-7_Human0.96637986
176CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.96254097
177KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.95172970
178BMI1_23680149_ChIP-Seq_NPCS_Mouse0.95170857
179GATA2_22383799_ChIP-Seq_G1ME_Mouse0.94082362
180CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.91400418
181CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.89463653
182BRD4_27068464_Chip-Seq_AML-cells_Mouse0.89027707
183ZNF263_19887448_ChIP-Seq_K562_Human0.88909043
184MAF_26560356_Chip-Seq_TH1_Human0.88873401
185NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.86633513
186ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.86388804
187ELK1_22589737_ChIP-Seq_MCF10A_Human0.86043052
188CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.85104784
189* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.84241407
190HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.83479331
191NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.81426929
192SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.80742318

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.64528339
2MP0003195_calcinosis3.67031524
3MP0010094_abnormal_chromosome_stability3.56730933
4MP0003111_abnormal_nucleus_morphology3.52473353
5MP0004957_abnormal_blastocyst_morpholog3.44840324
6MP0003077_abnormal_cell_cycle3.12672298
7MP0000569_abnormal_digit_pigmentation3.03853930
8MP0002396_abnormal_hematopoietic_system2.93345013
9MP0008057_abnormal_DNA_replication2.77540022
10MP0001835_abnormal_antigen_presentation2.69174634
11MP0001968_abnormal_touch/_nociception2.47974351
12MP0005397_hematopoietic_system_phenotyp2.46001984
13MP0001545_abnormal_hematopoietic_system2.46001984
14MP0005551_abnormal_eye_electrophysiolog2.45611146
15MP0009333_abnormal_splenocyte_physiolog2.40635820
16MP0008058_abnormal_DNA_repair2.37292191
17MP0008007_abnormal_cellular_replicative2.31178317
18MP0002736_abnormal_nociception_after2.30771572
19MP0005671_abnormal_response_to2.30671355
20MP0009046_muscle_twitch2.28366987
21MP0008872_abnormal_physiological_respon2.16112288
22MP0002138_abnormal_hepatobiliary_system2.12674383
23MP0004808_abnormal_hematopoietic_stem2.11955644
24MP0003656_abnormal_erythrocyte_physiolo2.11686517
25MP0001501_abnormal_sleep_pattern2.10016237
26MP0000372_irregular_coat_pigmentation2.07606145
27MP0006054_spinal_hemorrhage2.05746903
28MP0002102_abnormal_ear_morphology2.05295585
29MP0004043_abnormal_pH_regulation1.98387448
30MP0002837_dystrophic_cardiac_calcinosis1.97268420
31MP0003950_abnormal_plasma_membrane1.95765937
32MP0006292_abnormal_olfactory_placode1.95292539
33MP0002398_abnormal_bone_marrow1.93681001
34MP0003763_abnormal_thymus_physiology1.88324521
35MP0004145_abnormal_muscle_electrophysio1.85241342
36MP0009785_altered_susceptibility_to1.84380739
37MP0005253_abnormal_eye_physiology1.80052580
38MP0005646_abnormal_pituitary_gland1.78959981
39MP0000427_abnormal_hair_cycle1.77573113
40MP0004142_abnormal_muscle_tone1.75733342
41MP0001730_embryonic_growth_arrest1.75220099
42MP0006072_abnormal_retinal_apoptosis1.74547866
43MP0001800_abnormal_humoral_immune1.67879189
44MP0000689_abnormal_spleen_morphology1.67816639
45MP0009745_abnormal_behavioral_response1.67500218
46MP0000685_abnormal_immune_system1.64202966
47MP0003186_abnormal_redox_activity1.63518828
48MP0002420_abnormal_adaptive_immunity1.62602971
49MP0000383_abnormal_hair_follicle1.62601709
50MP0001819_abnormal_immune_cell1.61625358
51MP0005645_abnormal_hypothalamus_physiol1.61557967
52MP0002722_abnormal_immune_system1.60931428
53MP0002452_abnormal_antigen_presenting1.60031245
54MP0000490_abnormal_crypts_of1.58151380
55MP0003136_yellow_coat_color1.57364463
56MP0008932_abnormal_embryonic_tissue1.56845795
57MP0002876_abnormal_thyroid_physiology1.55075964
58MP0005075_abnormal_melanosome_morpholog1.55064895
59MP0005464_abnormal_platelet_physiology1.54725657
60MP0002148_abnormal_hypersensitivity_rea1.53799631
61MP0002429_abnormal_blood_cell1.53071598
62MP0000716_abnormal_immune_system1.52669425
63MP0008875_abnormal_xenobiotic_pharmacok1.52460680
64MP0005000_abnormal_immune_tolerance1.52450775
65MP0002166_altered_tumor_susceptibility1.51989739
66MP0003724_increased_susceptibility_to1.50319125
67MP0003436_decreased_susceptibility_to1.50080044
68MP0002938_white_spotting1.49338606
69MP0002019_abnormal_tumor_incidence1.48608831
70MP0002638_abnormal_pupillary_reflex1.48141312
71MP0001986_abnormal_taste_sensitivity1.48054120
72MP0001485_abnormal_pinna_reflex1.47379451
73MP0000350_abnormal_cell_proliferation1.47321950
74MP0002132_abnormal_respiratory_system1.46448781
75MP0002723_abnormal_immune_serum1.46067697
76MP0003718_maternal_effect1.45839852
77MP0003221_abnormal_cardiomyocyte_apopto1.45597334
78MP0003252_abnormal_bile_duct1.44959829
79MP0003806_abnormal_nucleotide_metabolis1.43651894
80MP0006276_abnormal_autonomic_nervous1.43211469
81MP0010386_abnormal_urinary_bladder1.42224984
82MP0005025_abnormal_response_to1.41883855
83MP0006036_abnormal_mitochondrial_physio1.39197687
84MP0000313_abnormal_cell_death1.36770702
85MP0010307_abnormal_tumor_latency1.34958897
86MP0002419_abnormal_innate_immunity1.31964247
87MP0002272_abnormal_nervous_system1.31590207
88MP0004147_increased_porphyrin_level1.29973458
89MP0003011_delayed_dark_adaptation1.29824315
90MP0002160_abnormal_reproductive_system1.28779586
91MP0002006_tumorigenesis1.28408269
92MP0000703_abnormal_thymus_morphology1.27963423
93MP0000631_abnormal_neuroendocrine_gland1.26087080
94MP0003786_premature_aging1.25643699
95MP0002405_respiratory_system_inflammati1.23063659
96MP0001853_heart_inflammation1.21748411
97MP0005085_abnormal_gallbladder_physiolo1.21218059
98MP0000858_altered_metastatic_potential1.20657425
99MP0004885_abnormal_endolymph1.17976108
100MP0008877_abnormal_DNA_methylation1.17640332
101MP0002080_prenatal_lethality1.16679661
102MP0001697_abnormal_embryo_size1.16333246
103MP0000465_gastrointestinal_hemorrhage1.16062342
104MP0005380_embryogenesis_phenotype1.15967171
105MP0001672_abnormal_embryogenesis/_devel1.15967171
106MP0000358_abnormal_cell_content/1.15712432
107MP0003646_muscle_fatigue1.15558151
108MP0004084_abnormal_cardiac_muscle1.15223673
109MP0001790_abnormal_immune_system1.14330332
110MP0005387_immune_system_phenotype1.14330332
111MP0005389_reproductive_system_phenotype1.12987679
112MP0003890_abnormal_embryonic-extraembry1.11526255
113MP0003984_embryonic_growth_retardation1.11278606
114MP0005310_abnormal_salivary_gland1.11074309
115MP0009697_abnormal_copulation1.10848851
116MP0002735_abnormal_chemical_nociception1.10074327
117MP0010352_gastrointestinal_tract_polyps1.09136363
118MP0002088_abnormal_embryonic_growth/wei1.08861059
119MP0000230_abnormal_systemic_arterial1.08264160
120MP0008260_abnormal_autophagy1.08247727
121MP0003045_fibrosis1.07980885
122MP0005410_abnormal_fertilization1.07732487
123MP0010155_abnormal_intestine_physiology1.07607267
124MP0009840_abnormal_foam_cell1.07597200
125MP0001486_abnormal_startle_reflex1.07111640
126MP0005084_abnormal_gallbladder_morpholo1.06468761
127MP0005174_abnormal_tail_pigmentation1.05312551
128MP0005266_abnormal_metabolism1.04673373
129MP0003172_abnormal_lysosome_physiology1.00904183
130MP0003567_abnormal_fetal_cardiomyocyte1.00742701
131MP0006082_CNS_inflammation1.00361837
132MP0004133_heterotaxia0.99807404
133MP0002086_abnormal_extraembryonic_tissu0.98978457
134MP0005395_other_phenotype0.98009592
135MP0002163_abnormal_gland_morphology0.97537192
136MP0002234_abnormal_pharynx_morphology0.96861644
137MP0000343_altered_response_to0.95155502
138MP0003787_abnormal_imprinting0.94854601
139MP0003698_abnormal_male_reproductive0.94368676
140MP0002733_abnormal_thermal_nociception0.93772067
141MP0002067_abnormal_sensory_capabilities0.93567012
142MP0005167_abnormal_blood-brain_barrier0.92796175
143MP0008961_abnormal_basal_metabolism0.91733623
144MP0002928_abnormal_bile_duct0.90045315
145MP0004215_abnormal_myocardial_fiber0.89843930
146MP0001845_abnormal_inflammatory_respons0.88685960
147MP0002693_abnormal_pancreas_physiology0.88563016
148MP0009764_decreased_sensitivity_to0.87909516
149MP0006035_abnormal_mitochondrial_morpho0.87687471
150MP0001970_abnormal_pain_threshold0.86674502
151MP0002653_abnormal_ependyma_morphology0.85243696
152MP0002933_joint_inflammation0.85125690
153MP0005386_behavior/neurological_phenoty0.84664836
154MP0004924_abnormal_behavior0.84664836
155MP0003119_abnormal_digestive_system0.83805932
156MP0001929_abnormal_gametogenesis0.83410743
157MP0003448_altered_tumor_morphology0.83162049
158MP0000371_diluted_coat_color0.82563930
159MP0002064_seizures0.81555840
160MP0002572_abnormal_emotion/affect_behav0.81420485
161MP0000653_abnormal_sex_gland0.81093126
162MP0005195_abnormal_posterior_eye0.80754666
163MP0001533_abnormal_skeleton_physiology0.79877806
164MP0000538_abnormal_urinary_bladder0.78812098
165MP0008469_abnormal_protein_level0.77190317
166MP0002168_other_aberrant_phenotype0.76259809
167MP0002229_neurodegeneration0.76071161
168MP0002095_abnormal_skin_pigmentation0.75787826
169MP0003137_abnormal_impulse_conducting0.75569260
170MP0002210_abnormal_sex_determination0.74491777
171MP0002557_abnormal_social/conspecific_i0.74029653
172MP0009278_abnormal_bone_marrow0.74003881
173MP0000750_abnormal_muscle_regeneration0.73011369
174MP0001984_abnormal_olfaction0.72715753
175MP0001145_abnormal_male_reproductive0.71561602
176MP0000470_abnormal_stomach_morphology0.71464026
177MP0001915_intracranial_hemorrhage0.71167558
178MP0005670_abnormal_white_adipose0.70789183
179MP0001919_abnormal_reproductive_system0.70765830
180MP0001764_abnormal_homeostasis0.69702124
181MP0003943_abnormal_hepatobiliary_system0.69309089
182MP0005384_cellular_phenotype0.68519567
183MP0001324_abnormal_eye_pigmentation0.68261854
184MP0002085_abnormal_embryonic_tissue0.64222754

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of cells of the erythroid lineage (HP:0012130)4.90663455
2Abnormal number of erythroid precursors (HP:0012131)4.87181903
3Pancreatic cysts (HP:0001737)4.73238951
4Reticulocytopenia (HP:0001896)4.36607847
5Pancreatic fibrosis (HP:0100732)4.10215613
6Genetic anticipation (HP:0003743)4.05286004
7True hermaphroditism (HP:0010459)3.98332059
8Aplastic anemia (HP:0001915)3.88481995
9Abnormality of the anterior horn cell (HP:0006802)3.79717831
10Degeneration of anterior horn cells (HP:0002398)3.79717831
11Congenital stationary night blindness (HP:0007642)3.79282800
12Molar tooth sign on MRI (HP:0002419)3.65837150
13Abnormality of midbrain morphology (HP:0002418)3.65837150
14Gaze-evoked nystagmus (HP:0000640)3.64497154
15Thrombocytosis (HP:0001894)3.34052727
16Progressive cerebellar ataxia (HP:0002073)3.26658152
17Nephronophthisis (HP:0000090)3.25708726
18Birth length less than 3rd percentile (HP:0003561)3.21409595
19Abnormality of the heme biosynthetic pathway (HP:0010472)3.20952730
20Attenuation of retinal blood vessels (HP:0007843)3.20530486
21Abnormality of the renal cortex (HP:0011035)3.17800189
22IgM deficiency (HP:0002850)3.15874968
23Multiple enchondromatosis (HP:0005701)3.12949108
24Hyperventilation (HP:0002883)3.12920173
25Chronic otitis media (HP:0000389)3.08073373
26Cerebral hypomyelination (HP:0006808)3.01037481
27Abnormality of the renal medulla (HP:0100957)2.98362292
28Carpal bone hypoplasia (HP:0001498)2.93067752
29Cystic liver disease (HP:0006706)2.87636126
30Rough bone trabeculation (HP:0100670)2.87140023
31Pallor (HP:0000980)2.84682213
32Petechiae (HP:0000967)2.83192695
33Abolished electroretinogram (ERG) (HP:0000550)2.82527786
34Nasal polyposis (HP:0100582)2.78660696
35Oral leukoplakia (HP:0002745)2.70186235
36Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.69677951
37Abnormality of alanine metabolism (HP:0010916)2.69677951
38Hyperalaninemia (HP:0003348)2.69677951
39Type 2 muscle fiber atrophy (HP:0003554)2.68723000
40Aplasia/Hypoplasia of the tibia (HP:0005772)2.68541138
41Macrocytic anemia (HP:0001972)2.68346316
42Reduced antithrombin III activity (HP:0001976)2.67509778
43Muscle fiber atrophy (HP:0100295)2.67020646
44Chronic hepatic failure (HP:0100626)2.66272880
45Medial flaring of the eyebrow (HP:0010747)2.66141475
46Recurrent bronchitis (HP:0002837)2.61279250
47Clumsiness (HP:0002312)2.54369399
48Pendular nystagmus (HP:0012043)2.53374870
49Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.51126495
50Decreased activity of mitochondrial respiratory chain (HP:0008972)2.51126495
51Myelodysplasia (HP:0002863)2.50700698
52Pustule (HP:0200039)2.50035161
53Prolonged bleeding time (HP:0003010)2.50030074
54Spinal muscular atrophy (HP:0007269)2.46662779
55Sclerocornea (HP:0000647)2.46094525
56Abnormality of the nasal mucosa (HP:0000433)2.46052481
57Breast hypoplasia (HP:0003187)2.45799303
58IgG deficiency (HP:0004315)2.43138914
59Recurrent viral infections (HP:0004429)2.42145574
60Large for gestational age (HP:0001520)2.42085502
61Hypoplasia of the capital femoral epiphysis (HP:0003090)2.41408072
62Furrowed tongue (HP:0000221)2.40979344
63Tongue fasciculations (HP:0001308)2.40930486
64Irregular epiphyses (HP:0010582)2.39921951
65Recurrent abscess formation (HP:0002722)2.38686699
66Stomach cancer (HP:0012126)2.36442895
67Bile duct proliferation (HP:0001408)2.35667893
68Abnormal biliary tract physiology (HP:0012439)2.35667893
69Abnormality of T cell physiology (HP:0011840)2.34993576
70Areflexia of lower limbs (HP:0002522)2.33680914
71Tubular atrophy (HP:0000092)2.33131830
72Cleft eyelid (HP:0000625)2.31903555
73Inability to walk (HP:0002540)2.31843594
74Aplasia/Hypoplasia of the tongue (HP:0010295)2.31669326
75Congenital sensorineural hearing impairment (HP:0008527)2.31490759
76Type II lissencephaly (HP:0007260)2.31328883
77Bone marrow hypocellularity (HP:0005528)2.30434769
78Abnormality of T cells (HP:0002843)2.30118017
79Congenital hepatic fibrosis (HP:0002612)2.28806889
80Abnormal drinking behavior (HP:0030082)2.27800669
81Polydipsia (HP:0001959)2.27800669
82Type I transferrin isoform profile (HP:0003642)2.27561677
83Congenital, generalized hypertrichosis (HP:0004540)2.27167840
84Atrophy/Degeneration involving motor neurons (HP:0007373)2.25679004
85Eosinophilia (HP:0001880)2.24900116
86Granulocytopenia (HP:0001913)2.23096743
87Chromsome breakage (HP:0040012)2.22161413
88Progressive inability to walk (HP:0002505)2.22075366
89Bony spicule pigmentary retinopathy (HP:0007737)2.20932437
90Fair hair (HP:0002286)2.20731963
91Lymphoma (HP:0002665)2.20711033
92Muscle fibrillation (HP:0010546)2.20429444
93Abnormality of the pons (HP:0007361)2.19332394
94Decreased electroretinogram (ERG) amplitude (HP:0000654)2.19106988
95Keratoconus (HP:0000563)2.18322502
96Increased corneal curvature (HP:0100692)2.18322502
97Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.17849795
98Absent epiphyses (HP:0010577)2.17849795
99Obstructive lung disease (HP:0006536)2.16484594
100Chronic obstructive pulmonary disease (HP:0006510)2.16484594
101Pancytopenia (HP:0001876)2.15653188
102Decreased central vision (HP:0007663)2.14406060
103Hypoplasia of the pons (HP:0012110)2.13497684
104Poor head control (HP:0002421)2.11923185
105Protruding tongue (HP:0010808)2.11869356
106Panhypogammaglobulinemia (HP:0003139)2.11629777
107Anencephaly (HP:0002323)2.11296998
108Renal cortical cysts (HP:0000803)2.11206723
109Hypothermia (HP:0002045)2.10647094
110Pulmonary fibrosis (HP:0002206)2.09509862
111CNS hypomyelination (HP:0003429)2.09347012
112Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.09126227
113Abnormality of reticulocytes (HP:0004312)2.08428047
114Increased CSF lactate (HP:0002490)2.06386580
115Abnormality of chromosome stability (HP:0003220)2.06300913
116Increased serum lactate (HP:0002151)2.05840751
1173-Methylglutaconic aciduria (HP:0003535)2.05373497
118Ureteral duplication (HP:0000073)2.05105180
119Broad-based gait (HP:0002136)2.05027481
120Decreased circulating renin level (HP:0003351)2.04975578
121Aplasia/Hypoplasia of the uvula (HP:0010293)2.04788956
122Recurrent bacterial skin infections (HP:0005406)2.04569370
123Chromosomal breakage induced by crosslinking agents (HP:0003221)2.03941508
124Nemaline bodies (HP:0003798)2.03911328
125Selective tooth agenesis (HP:0001592)2.03717494
126Glossoptosis (HP:0000162)2.03215263
127Male pseudohermaphroditism (HP:0000037)2.02827709
128B lymphocytopenia (HP:0010976)2.02413490
129Abnormality of B cell number (HP:0010975)2.02413490
130Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.01721726
131Absent thumb (HP:0009777)2.01530456
132Sparse eyelashes (HP:0000653)2.01258662
133Dynein arm defect of respiratory motile cilia (HP:0012255)2.01206571
134Absent/shortened dynein arms (HP:0200106)2.01206571
135Abnormal spermatogenesis (HP:0008669)2.00906029
136Methylmalonic aciduria (HP:0012120)2.00850942
137Abnormality of glycolysis (HP:0004366)2.00087615
138Increased serum pyruvate (HP:0003542)2.00087615
139Congenital primary aphakia (HP:0007707)1.99818335
140Abnormality of the preputium (HP:0100587)1.98953231
141Abnormal rod and cone electroretinograms (HP:0008323)1.97839502
142Aplasia/Hypoplasia of the thymus (HP:0010515)1.97634286
143Meckel diverticulum (HP:0002245)1.97391695
144Trismus (HP:0000211)1.97096785
145Abnormality of the umbilical cord (HP:0010881)1.96915411
146Hepatocellular necrosis (HP:0001404)1.96652630
147Methylmalonic acidemia (HP:0002912)1.95769495
148Increased neuronal autofluorescent lipopigment (HP:0002074)1.94780700
149Gait imbalance (HP:0002141)1.94715149
15011 pairs of ribs (HP:0000878)1.93695695
151Abnormality of the ileum (HP:0001549)1.93693919
152Abnormality of macular pigmentation (HP:0008002)1.93637619
153Abnormality of the renal collecting system (HP:0004742)1.93435352
154Combined immunodeficiency (HP:0005387)1.92860057
155Abnormality of eosinophils (HP:0001879)1.92698582
156Rhabdomyolysis (HP:0003201)1.91773702
157Postaxial foot polydactyly (HP:0001830)1.91614916
158Febrile seizures (HP:0002373)1.91329163
159Patellar aplasia (HP:0006443)1.90000804
160Bronchitis (HP:0012387)1.88830226
161Small hand (HP:0200055)1.88257573
162Aplasia/Hypoplasia of the patella (HP:0006498)1.88047034
163Constricted visual fields (HP:0001133)1.88043965
164Abnormal platelet function (HP:0011869)1.87738244
165Impaired platelet aggregation (HP:0003540)1.87738244
166Clubbing of toes (HP:0100760)1.87549173
167Progressive muscle weakness (HP:0003323)1.87416701
168Central scotoma (HP:0000603)1.87230766
169Prostate neoplasm (HP:0100787)1.86870904
170Cellular immunodeficiency (HP:0005374)1.86128481
171Abnormal trabecular bone morphology (HP:0100671)1.85057757
172Colon cancer (HP:0003003)1.83557994
173Agnosia (HP:0010524)1.82210209
174Epistaxis (HP:0000421)1.82184246
175Recurrent fungal infections (HP:0002841)1.81962909
176Aplasia/Hypoplasia of the fovea (HP:0008060)1.81901983
177Hypoplasia of the fovea (HP:0007750)1.81901983
178Polyuria (HP:0000103)1.81627978
179Chorioretinal atrophy (HP:0000533)1.81134819
180Hepatic necrosis (HP:0002605)1.80939631
181Mitochondrial inheritance (HP:0001427)1.80121249
182Cerebellar dysplasia (HP:0007033)1.80077917
183Dialeptic seizures (HP:0011146)1.79967162
184Genital tract atresia (HP:0001827)1.78925209
185Sloping forehead (HP:0000340)1.78642338
186Nephrogenic diabetes insipidus (HP:0009806)1.78433218
187Abnormal ciliary motility (HP:0012262)1.76710567
188Abnormal protein glycosylation (HP:0012346)1.75701345
189Abnormal glycosylation (HP:0012345)1.75701345
190Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.75701345
191Abnormal protein N-linked glycosylation (HP:0012347)1.75701345
192Absent speech (HP:0001344)1.75382540
193Preaxial hand polydactyly (HP:0001177)1.73654684
194Ketoacidosis (HP:0001993)1.72971064
195Ketosis (HP:0001946)1.72831352

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK8.14895640
2BUB14.31276807
3WEE13.84632178
4BMPR1B3.73920024
5EIF2AK13.33757453
6NME23.30764170
7ADRBK23.12578345
8STK163.00630410
9INSRR2.77252380
10NUAK12.41538132
11GRK12.35964343
12CDC72.33541135
13BRSK22.27262343
14VRK12.27134539
15MAP4K12.24854369
16TAOK32.17301172
17NEK12.11938079
18NEK22.07571686
19MAP4K22.04502578
20PIM22.01155337
21PDK41.96586880
22PDK31.96586880
23PLK41.88895284
24SCYL21.84005266
25WNK31.83830063
26OXSR11.81998056
27STK241.81377433
28DYRK31.75971867
29STK101.74452439
30TESK11.69889052
31RPS6KA41.66353480
32KDR1.59721143
33TESK21.55842175
34PINK11.53597251
35TSSK61.47745072
36STK38L1.44263983
37EIF2AK31.36561650
38PLK11.35554445
39PDK21.35307286
40SRPK11.34176548
41ZAP701.32134134
42PLK31.28316814
43TTK1.27681387
44MAPK131.26435358
45LRRK21.24901336
46STK31.23675877
47ADRBK11.20874380
48WNK41.18855453
49ACVR1B1.18608114
50CDK41.18195992
51PIM11.17207981
52AURKB1.15509564
53PIK3CG1.15371642
54CCNB11.13425056
55MAP2K31.11830185
56TIE11.11619934
57TNIK1.10850627
58STK391.08111747
59TBK11.07954529
60VRK21.06212865
61MST41.06108911
62NEK91.02981939
63NME11.02847035
64DAPK21.01284562
65AKT30.99490238
66MKNK10.98526725
67RPS6KB20.94406084
68STK40.94087258
69GRK60.94071427
70KIT0.92447332
71MAP3K80.92042977
72BRSK10.90282645
73MUSK0.89837288
74EEF2K0.88501151
75MAP3K40.88176361
76JAK30.87833618
77TXK0.87680042
78PAK40.87654256
79MAPKAPK30.87025019
80PRKCE0.86126536
81NLK0.85211446
82ATR0.84831532
83TYK20.84106974
84PTK2B0.84006586
85TGFBR20.83592077
86MKNK20.81834603
87IKBKB0.81287290
88BTK0.80950793
89OBSCN0.80264109
90CDK70.78960166
91MAP3K110.78911729
92AURKA0.75258895
93BCKDK0.75206794
94FER0.74181283
95TEC0.73626937
96CDK190.73429636
97TNK20.72343504
98SYK0.72300068
99PLK20.71612559
100PAK30.71347963
101CDK80.67200789
102LIMK10.67001895
103TGFBR10.66863468
104CHEK20.66626599
105MARK30.65810585
106LATS10.65032750
107CSF1R0.62783723
108PIK3CA0.62739139
109NTRK30.62422570
110PRKCG0.62331609
111CHEK10.61652284
112TRIM280.59934885
113PRKG20.59338384
114MAP3K30.58471073
115CASK0.58087917
116IRAK10.57724573
117ITK0.57533954
118ZAK0.56565669
119CSNK2A10.55488599
120CDK60.55256596
121ALK0.54491667
122CSNK1G10.54474061
123ILK0.54369726
124EIF2AK20.54036281
125CSNK1A1L0.53688267
126TAF10.53583329
127PAK10.52744535
128MAP3K100.51390799
129PRKAA20.49122540
130LYN0.48310159
131MATK0.45617293
132CSNK2A20.45513241
133MAPKAPK50.44975853
134CAMKK20.44829537
135GRK70.44391543
136DYRK20.43697689
137MAP2K60.43099985
138PASK0.42198612
139RPS6KA50.42158968
140PNCK0.41705810
141CSNK1G30.41628965
142MELK0.41240724
143MAPK40.40614213
144ABL20.39911066
145CSNK1G20.39850265
146TLK10.39695780
147GRK50.38431399
148SGK20.38369842
149CAMK2A0.37710216
150PRKCQ0.37325082
151CHUK0.36701708
152CDK20.36675717
153LCK0.35579233
154CSNK1A10.34652322
155PKN10.33785126
156BLK0.33632553
157MAP3K70.33500798
158STK110.33064056
159CAMK10.32930741
160PRKACA0.31992288
161FLT30.31571945
162TRPM70.31330059
163CSNK1D0.30737828
164MAPKAPK20.30663239
165ATM0.30525559
166BCR0.30001474
167PHKG20.28342553
168CSK0.26536395

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030504.25957162
2DNA replication_Homo sapiens_hsa030304.02203647
3Ribosome_Homo sapiens_hsa030103.76745792
4RNA polymerase_Homo sapiens_hsa030203.45860643
5Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.41805052
6Mismatch repair_Homo sapiens_hsa034303.29384784
7RNA transport_Homo sapiens_hsa030132.74626349
8Spliceosome_Homo sapiens_hsa030402.68831857
9Base excision repair_Homo sapiens_hsa034102.67259964
10Vitamin B6 metabolism_Homo sapiens_hsa007502.60663938
11Phototransduction_Homo sapiens_hsa047442.51326368
12Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.46409189
13Pyrimidine metabolism_Homo sapiens_hsa002402.44002797
14Homologous recombination_Homo sapiens_hsa034402.37580879
15Nitrogen metabolism_Homo sapiens_hsa009102.35467223
16Butanoate metabolism_Homo sapiens_hsa006502.33766596
17Linoleic acid metabolism_Homo sapiens_hsa005912.27096371
18Tryptophan metabolism_Homo sapiens_hsa003802.26083028
19Cell cycle_Homo sapiens_hsa041102.19457821
20Nucleotide excision repair_Homo sapiens_hsa034202.16935595
21alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.04987825
22Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.97200644
23Primary bile acid biosynthesis_Homo sapiens_hsa001201.91109350
24Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.90864723
25Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.88741988
26Basal transcription factors_Homo sapiens_hsa030221.87046926
27Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.86614959
28Non-homologous end-joining_Homo sapiens_hsa034501.81011003
29Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.79387353
30ABC transporters_Homo sapiens_hsa020101.71562559
31Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.67748076
32Ether lipid metabolism_Homo sapiens_hsa005651.66479256
33Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.65820147
34Steroid hormone biosynthesis_Homo sapiens_hsa001401.64304002
35Primary immunodeficiency_Homo sapiens_hsa053401.61902715
36Antigen processing and presentation_Homo sapiens_hsa046121.58592279
37Fanconi anemia pathway_Homo sapiens_hsa034601.56336262
38Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.52225393
39Maturity onset diabetes of the young_Homo sapiens_hsa049501.49302372
40Pentose phosphate pathway_Homo sapiens_hsa000301.49013284
41Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.48588936
42Nicotine addiction_Homo sapiens_hsa050331.48552594
43Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.47129382
44Propanoate metabolism_Homo sapiens_hsa006401.44531140
45Taste transduction_Homo sapiens_hsa047421.44325741
46RNA degradation_Homo sapiens_hsa030181.42463139
47Chemical carcinogenesis_Homo sapiens_hsa052041.40412721
48Olfactory transduction_Homo sapiens_hsa047401.38026982
49Purine metabolism_Homo sapiens_hsa002301.36758410
50Epstein-Barr virus infection_Homo sapiens_hsa051691.35331460
51p53 signaling pathway_Homo sapiens_hsa041151.35092557
52Retinol metabolism_Homo sapiens_hsa008301.27490349
53Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.24912663
54Folate biosynthesis_Homo sapiens_hsa007901.22071408
55One carbon pool by folate_Homo sapiens_hsa006701.16269228
56Protein export_Homo sapiens_hsa030601.13719486
57Herpes simplex infection_Homo sapiens_hsa051681.13306134
58Legionellosis_Homo sapiens_hsa051341.09648730
59Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.08937147
60Morphine addiction_Homo sapiens_hsa050321.05727175
61Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.03042194
62Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.02447773
63Peroxisome_Homo sapiens_hsa041461.01121822
64Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.99539571
65mRNA surveillance pathway_Homo sapiens_hsa030150.94846472
66Glycerolipid metabolism_Homo sapiens_hsa005610.94307539
67beta-Alanine metabolism_Homo sapiens_hsa004100.93942541
68Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.93592898
69Ovarian steroidogenesis_Homo sapiens_hsa049130.91529149
70Measles_Homo sapiens_hsa051620.88701553
71Systemic lupus erythematosus_Homo sapiens_hsa053220.87386335
72Shigellosis_Homo sapiens_hsa051310.86568671
73Hematopoietic cell lineage_Homo sapiens_hsa046400.85937735
74Viral carcinogenesis_Homo sapiens_hsa052030.85108976
75Serotonergic synapse_Homo sapiens_hsa047260.84626555
76Huntingtons disease_Homo sapiens_hsa050160.81147537
77Sulfur relay system_Homo sapiens_hsa041220.80951147
78Salivary secretion_Homo sapiens_hsa049700.79366620
79Parkinsons disease_Homo sapiens_hsa050120.78454434
80Calcium signaling pathway_Homo sapiens_hsa040200.76863977
81Cysteine and methionine metabolism_Homo sapiens_hsa002700.76777134
82Regulation of autophagy_Homo sapiens_hsa041400.76219146
83Intestinal immune network for IgA production_Homo sapiens_hsa046720.75406562
84Histidine metabolism_Homo sapiens_hsa003400.73947628
85Glutathione metabolism_Homo sapiens_hsa004800.71605270
86Alzheimers disease_Homo sapiens_hsa050100.71391706
87Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.70180921
88Oocyte meiosis_Homo sapiens_hsa041140.68672113
89Fructose and mannose metabolism_Homo sapiens_hsa000510.67244992
90Circadian entrainment_Homo sapiens_hsa047130.66468034
91Carbon metabolism_Homo sapiens_hsa012000.64717520
92Pentose and glucuronate interconversions_Homo sapiens_hsa000400.64629745
93Leishmaniasis_Homo sapiens_hsa051400.63257963
94Glutamatergic synapse_Homo sapiens_hsa047240.62902510
95Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.62813227
96Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.62652270
97Biosynthesis of amino acids_Homo sapiens_hsa012300.62173552
98Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.61327900
99Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.60883768
100Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.60031374
101B cell receptor signaling pathway_Homo sapiens_hsa046620.59280929
102Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.58907464
103Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.56423532
104GABAergic synapse_Homo sapiens_hsa047270.56420458
105Fatty acid degradation_Homo sapiens_hsa000710.56068005
106NF-kappa B signaling pathway_Homo sapiens_hsa040640.54971469
107Graft-versus-host disease_Homo sapiens_hsa053320.54526232
108Dorso-ventral axis formation_Homo sapiens_hsa043200.54034892
109Vitamin digestion and absorption_Homo sapiens_hsa049770.53725184
110Apoptosis_Homo sapiens_hsa042100.53351279
111HTLV-I infection_Homo sapiens_hsa051660.52692457
112Allograft rejection_Homo sapiens_hsa053300.51780271
113Circadian rhythm_Homo sapiens_hsa047100.51431005
114SNARE interactions in vesicular transport_Homo sapiens_hsa041300.51100145
115Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.50971027
116Cardiac muscle contraction_Homo sapiens_hsa042600.50629744
117Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.50336610
118Drug metabolism - other enzymes_Homo sapiens_hsa009830.50003682
119Vascular smooth muscle contraction_Homo sapiens_hsa042700.49604815
120Insulin secretion_Homo sapiens_hsa049110.49442101
121Type I diabetes mellitus_Homo sapiens_hsa049400.49228572
122Influenza A_Homo sapiens_hsa051640.48152701
123Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.47929875
124Fatty acid biosynthesis_Homo sapiens_hsa000610.47511071
125Viral myocarditis_Homo sapiens_hsa054160.47252650
126Autoimmune thyroid disease_Homo sapiens_hsa053200.46718586
127Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.46567861
128Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.45873709
129Transcriptional misregulation in cancer_Homo sapiens_hsa052020.45481836
130Oxidative phosphorylation_Homo sapiens_hsa001900.43946673
131Thyroid cancer_Homo sapiens_hsa052160.43646685
132RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.43613344
133Other glycan degradation_Homo sapiens_hsa005110.43354589
134Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.42866784
135Lysine degradation_Homo sapiens_hsa003100.42605599
1362-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.41381322
137Selenocompound metabolism_Homo sapiens_hsa004500.41288382
138Acute myeloid leukemia_Homo sapiens_hsa052210.39457386
139Hepatitis B_Homo sapiens_hsa051610.39375520
140Renin-angiotensin system_Homo sapiens_hsa046140.39114528
141Mineral absorption_Homo sapiens_hsa049780.37695649
142Galactose metabolism_Homo sapiens_hsa000520.37596536
143Caffeine metabolism_Homo sapiens_hsa002320.36771396
144NOD-like receptor signaling pathway_Homo sapiens_hsa046210.36724428
145Glycerophospholipid metabolism_Homo sapiens_hsa005640.36515847
146Sphingolipid metabolism_Homo sapiens_hsa006000.35794234
147Fat digestion and absorption_Homo sapiens_hsa049750.35580237
148Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.35222175
149Salmonella infection_Homo sapiens_hsa051320.34584062
150Arachidonic acid metabolism_Homo sapiens_hsa005900.31693186
151Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.31622799
152Asthma_Homo sapiens_hsa053100.31385587
153Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.30375256
154T cell receptor signaling pathway_Homo sapiens_hsa046600.30239455
155Jak-STAT signaling pathway_Homo sapiens_hsa046300.29827506
156Small cell lung cancer_Homo sapiens_hsa052220.28530678
157Metabolic pathways_Homo sapiens_hsa011000.27492853
158Tuberculosis_Homo sapiens_hsa051520.27334117
159Colorectal cancer_Homo sapiens_hsa052100.27061713
160Pertussis_Homo sapiens_hsa051330.26467539
161Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.25963641
162Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.25454008

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