INO80D

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of histone H3-K27 methylation (GO:0061085)4.49188017
2DNA double-strand break processing (GO:0000729)4.03118974
3protein prenylation (GO:0018342)3.96673628
4prenylation (GO:0097354)3.96673628
5positive regulation of gamma-delta T cell activation (GO:0046645)3.88300075
6histone H3-K4 trimethylation (GO:0080182)3.84529672
7negative regulation of execution phase of apoptosis (GO:1900118)3.81948598
8interferon-gamma production (GO:0032609)3.79820985
9protein K11-linked deubiquitination (GO:0035871)3.75645445
10negative regulation of translation, ncRNA-mediated (GO:0040033)3.75280274
11regulation of translation, ncRNA-mediated (GO:0045974)3.75280274
12negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.75280274
13establishment of protein localization to Golgi (GO:0072600)3.72691508
14antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.64778317
15positive regulation of histone H3-K4 methylation (GO:0051571)3.59836596
16protein targeting to Golgi (GO:0000042)3.50216443
17lactate metabolic process (GO:0006089)3.45547979
18kidney morphogenesis (GO:0060993)3.39032004
19histone H2A acetylation (GO:0043968)3.31335552
20atrial cardiac muscle cell action potential (GO:0086014)3.29522747
21fucose catabolic process (GO:0019317)3.28477121
22L-fucose metabolic process (GO:0042354)3.28477121
23L-fucose catabolic process (GO:0042355)3.28477121
24response to pheromone (GO:0019236)3.28291790
25water-soluble vitamin biosynthetic process (GO:0042364)3.28086827
26histone H3-K4 methylation (GO:0051568)3.25681323
27retrograde transport, vesicle recycling within Golgi (GO:0000301)3.24542029
28mitotic sister chromatid cohesion (GO:0007064)3.16633456
29signal peptide processing (GO:0006465)3.16602558
30inositol phosphate catabolic process (GO:0071545)3.13274529
31neural tube formation (GO:0001841)3.10225274
32histone H3-K36 demethylation (GO:0070544)3.09079774
33monoubiquitinated protein deubiquitination (GO:0035520)3.08317852
34regulation of glucokinase activity (GO:0033131)3.08146107
35regulation of hexokinase activity (GO:1903299)3.08146107
36positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO3.07072731
37regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)3.07072731
38interkinetic nuclear migration (GO:0022027)3.05135951
39mature B cell differentiation (GO:0002335)3.04921286
40negative T cell selection (GO:0043383)3.01442375
41replication fork processing (GO:0031297)2.97143707
42synapsis (GO:0007129)2.94504465
43negative thymic T cell selection (GO:0045060)2.94132692
44RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.88822147
45nodal signaling pathway (GO:0038092)2.88368488
46peptidyl-lysine trimethylation (GO:0018023)2.88102410
47respiratory chain complex IV assembly (GO:0008535)2.87432408
48regulation of Rac protein signal transduction (GO:0035020)2.85824391
49negative regulation of DNA-dependent DNA replication (GO:2000104)2.85572164
50definitive hemopoiesis (GO:0060216)2.83608232
51polyol catabolic process (GO:0046174)2.83546083
52regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)2.80965591
53positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)2.80965591
54radial glial cell differentiation (GO:0060019)2.80887691
55positive thymic T cell selection (GO:0045059)2.79926330
56regulation of gamma-delta T cell activation (GO:0046643)2.79706595
57insulin secretion (GO:0030073)2.79157020
58positive regulation of mRNA catabolic process (GO:0061014)2.79068262
59regulation of DNA endoreduplication (GO:0032875)2.78391758
60regulation of acyl-CoA biosynthetic process (GO:0050812)2.77057386
61negative regulation of DNA recombination (GO:0045910)2.76844856
62regulation of gamma-delta T cell differentiation (GO:0045586)2.76385552
63cytoplasmic mRNA processing body assembly (GO:0033962)2.74588824
64regulation of B cell receptor signaling pathway (GO:0050855)2.73532400
65positive T cell selection (GO:0043368)2.73157302
66regulation of nuclear cell cycle DNA replication (GO:0033262)2.72792307
67B cell homeostasis (GO:0001782)2.71960684
68negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.71703605
69negative regulation of cell killing (GO:0031342)2.71703605
70prostate gland growth (GO:0060736)2.70365499
71neutrophil activation (GO:0042119)2.70100502
72genitalia morphogenesis (GO:0035112)2.69730962
73keratinocyte development (GO:0003334)2.69339143
74positive regulation of mRNA processing (GO:0050685)2.69067902
75regulation of protein glycosylation (GO:0060049)2.68910243
76photoreceptor cell maintenance (GO:0045494)2.68651135
77leukocyte aggregation (GO:0070486)2.68210739
78negative regulation of JUN kinase activity (GO:0043508)2.68203684
79cellular ketone body metabolic process (GO:0046950)2.66919014
80regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.66320382
81positive regulation of protein autophosphorylation (GO:0031954)2.66093585
82cytochrome complex assembly (GO:0017004)2.65590486
83negative regulation of cytosolic calcium ion concentration (GO:0051481)2.64686540
84response to X-ray (GO:0010165)2.64670472
85somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.64386760
86somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.64386760
87isotype switching (GO:0045190)2.64386760
88regulation of meiosis I (GO:0060631)2.63626454
89microtubule anchoring (GO:0034453)2.59438284
90sister chromatid cohesion (GO:0007062)2.59017488
91platelet dense granule organization (GO:0060155)2.57938391
92presynaptic membrane assembly (GO:0097105)2.57931340
93dopamine transport (GO:0015872)2.57727708
94phosphorylated carbohydrate dephosphorylation (GO:0046838)2.56184125
95inositol phosphate dephosphorylation (GO:0046855)2.56184125
96positive regulation of mRNA metabolic process (GO:1903313)2.56102729
97proline transport (GO:0015824)2.55994229
98double-strand break repair via homologous recombination (GO:0000724)2.54799749
99positive regulation of glycoprotein biosynthetic process (GO:0010560)2.54541415
100recombinational repair (GO:0000725)2.53954178
101single strand break repair (GO:0000012)2.53466376
102T cell selection (GO:0045058)2.51853867
103embryonic hemopoiesis (GO:0035162)2.50988753
104nuclear pore complex assembly (GO:0051292)2.50844009
105regulation of histone methylation (GO:0031060)2.50285433
106thymic T cell selection (GO:0045061)2.48772690
107positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic proc2.48554645
108B cell receptor signaling pathway (GO:0050853)2.47697722
109mast cell activation (GO:0045576)2.47533929
110S-adenosylmethionine metabolic process (GO:0046500)2.46575221
111positive regulation of mRNA 3-end processing (GO:0031442)2.46320692
112regulation of telomere maintenance (GO:0032204)2.45373665
113response to muramyl dipeptide (GO:0032495)2.44966285
114granulocyte activation (GO:0036230)2.44319984
115regulation of B cell differentiation (GO:0045577)2.43801174
116regulation of mRNA catabolic process (GO:0061013)2.43306483
117CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)2.43183985
118T-helper cell differentiation (GO:0042093)2.43183985
119axoneme assembly (GO:0035082)2.42771252
120cellular extravasation (GO:0045123)2.42725726
121regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.42650548
122regulation of mitotic spindle checkpoint (GO:1903504)2.42650548
123regulation of chromatin silencing (GO:0031935)2.42545944
124positive regulation of granulocyte differentiation (GO:0030854)2.41957976
125ketone body metabolic process (GO:1902224)2.41826114
126T cell homeostasis (GO:0043029)2.41658448
127auditory receptor cell differentiation (GO:0042491)2.41513037
128intra-Golgi vesicle-mediated transport (GO:0006891)2.39969026
129dentate gyrus development (GO:0021542)2.39536939
130parental behavior (GO:0060746)2.39310230
131regulation of mRNA 3-end processing (GO:0031440)2.39012216
132positive regulation of organelle assembly (GO:1902117)2.38810517
133CD4-positive, alpha-beta T cell differentiation (GO:0043367)2.38582021
134phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.38487944
135T cell migration (GO:0072678)2.37581921
136regulation of stem cell maintenance (GO:2000036)2.37469928
137DNA deamination (GO:0045006)2.37051594
138RNA destabilization (GO:0050779)2.36859999
139germinal center formation (GO:0002467)2.36842792
140regulation of interleukin-12 biosynthetic process (GO:0045075)2.36564981
141positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.36144909
142dendritic cell chemotaxis (GO:0002407)2.34836716
143regulation of T cell tolerance induction (GO:0002664)2.34234560
144positive regulation of defense response to virus by host (GO:0002230)2.34204066
145detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.34196039
146regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.33782486
147megakaryocyte development (GO:0035855)2.33777249
148histone lysine methylation (GO:0034968)2.32707070
149somite rostral/caudal axis specification (GO:0032525)2.32487596
150developmental pigmentation (GO:0048066)2.32261180
151regulation of alpha-beta T cell proliferation (GO:0046640)2.31953132
152histone lysine demethylation (GO:0070076)2.31769777
153negative regulation of granulocyte differentiation (GO:0030853)2.31426215
154modulation by symbiont of host cellular process (GO:0044068)2.30883164
155tolerance induction (GO:0002507)2.30282318
156embryonic camera-type eye morphogenesis (GO:0048596)2.29531660
157positive regulation of B cell differentiation (GO:0045579)2.29284381
158modulation by virus of host process (GO:0019054)2.29199362
159regulation of helicase activity (GO:0051095)2.28659889
160dendritic cell migration (GO:0036336)2.28330926
161alpha-beta T cell activation (GO:0046631)2.28143892
162hepatocyte apoptotic process (GO:0097284)2.27007290
163alpha-beta T cell differentiation (GO:0046632)2.26690212
164T cell differentiation (GO:0030217)2.25986910
165lymphocyte homeostasis (GO:0002260)2.25714723
166negative regulation of alpha-beta T cell activation (GO:0046636)2.24761237
167response to peptidoglycan (GO:0032494)2.23791669
168negative regulation of T-helper cell differentiation (GO:0045623)2.23520857
169negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.23520857
170myeloid dendritic cell activation (GO:0001773)2.23377068
171negative regulation of phagocytosis (GO:0050765)2.23303440
172negative regulation of B cell proliferation (GO:0030889)2.23135631
173regulation of fibroblast apoptotic process (GO:2000269)2.21794186
174histone demethylation (GO:0016577)2.21553533
175lymphoid progenitor cell differentiation (GO:0002320)2.21227313
176response to interleukin-15 (GO:0070672)2.20386979
177histone mRNA catabolic process (GO:0071044)2.20365699
178regulation of interleukin-2 biosynthetic process (GO:0045076)2.17920785
179pre-miRNA processing (GO:0031054)2.17284395
180neutrophil activation involved in immune response (GO:0002283)2.16751894
181B cell differentiation (GO:0030183)2.16307851
182cellular response to interleukin-15 (GO:0071350)2.15324540
183alpha-beta T cell differentiation involved in immune response (GO:0002293)2.15210125
184alpha-beta T cell activation involved in immune response (GO:0002287)2.15210125
185T cell differentiation involved in immune response (GO:0002292)2.15210125
186pore complex assembly (GO:0046931)2.13709791
187regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.13421075

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse5.45499766
2E2F7_22180533_ChIP-Seq_HELA_Human5.01480811
3STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.10039790
4STAT3_20064451_ChIP-Seq_CD4+T_Mouse3.04656563
5EGR1_19374776_ChIP-ChIP_THP-1_Human3.03786015
6IRF8_22096565_ChIP-ChIP_GC-B_Human2.97140269
7BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.95244636
8GBX2_23144817_ChIP-Seq_PC3_Human2.90659718
9SMAD_19615063_ChIP-ChIP_OVARY_Human2.85565459
10BP1_19119308_ChIP-ChIP_Hs578T_Human2.73578093
11ZNF274_21170338_ChIP-Seq_K562_Hela2.69369283
12ZFP57_27257070_Chip-Seq_ESCs_Mouse2.64459694
13FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.63332060
14RUNX_20019798_ChIP-Seq_JUKART_Human2.62316386
15MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.46670606
16TAF15_26573619_Chip-Seq_HEK293_Human2.45114727
17GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.45007861
18SCL_19346495_ChIP-Seq_HPC-7_Human2.43032104
19SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.42165544
20IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.41464359
21HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.36607697
22FOXM1_23109430_ChIP-Seq_U2OS_Human2.35200664
23VDR_22108803_ChIP-Seq_LS180_Human2.21949898
24IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.20767551
25IRF8_27001747_Chip-Seq_BMDM_Mouse2.20378134
26P300_19829295_ChIP-Seq_ESCs_Human2.20066943
27TP63_19390658_ChIP-ChIP_HaCaT_Human2.19509823
28IRF8_21731497_ChIP-ChIP_J774_Mouse2.08710761
29VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.05156954
30MYB_26560356_Chip-Seq_TH2_Human2.04152265
31CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.03205015
32MYB_21317192_ChIP-Seq_ERMYB_Mouse1.96045516
33* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.94017298
34E2F4_17652178_ChIP-ChIP_JURKAT_Human1.93056601
35MYB_26560356_Chip-Seq_TH1_Human1.92896113
36NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.90711463
37CTBP2_25329375_ChIP-Seq_LNCAP_Human1.82616805
38SMAD4_21799915_ChIP-Seq_A2780_Human1.80187406
39PIAS1_25552417_ChIP-Seq_VCAP_Human1.77630614
40ER_23166858_ChIP-Seq_MCF-7_Human1.77438791
41SALL1_21062744_ChIP-ChIP_HESCs_Human1.74057962
42MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.73662659
43MYC_22102868_ChIP-Seq_BL_Human1.69040913
44SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.66449651
45* FLI1_27457419_Chip-Seq_LIVER_Mouse1.66318834
46STAT4_19710469_ChIP-ChIP_TH1__Mouse1.65580490
47CTBP1_25329375_ChIP-Seq_LNCAP_Human1.64227118
48SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.63524987
49* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.63035128
50STAT3_23295773_ChIP-Seq_U87_Human1.60788622
51* PCGF2_27294783_Chip-Seq_ESCs_Mouse1.59524540
52NOTCH1_21737748_ChIP-Seq_TLL_Human1.58875491
53Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.57235900
54BCAT_22108803_ChIP-Seq_LS180_Human1.56119209
55UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.54653444
56VDR_24787735_ChIP-Seq_THP-1_Human1.52078319
57PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.51359946
58* PU_27001747_Chip-Seq_BMDM_Mouse1.50197723
59SMAD3_21741376_ChIP-Seq_EPCs_Human1.48897995
60MAF_26560356_Chip-Seq_TH1_Human1.46675734
61CBP_20019798_ChIP-Seq_JUKART_Human1.44750709
62IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.44750709
63AR_25329375_ChIP-Seq_VCAP_Human1.43900289
64TCF7_22412390_ChIP-Seq_EML_Mouse1.42725623
65* TCF4_23295773_ChIP-Seq_U87_Human1.42207253
66VDR_24763502_ChIP-Seq_THP-1_Human1.41839834
67SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.40574725
68ELK1_19687146_ChIP-ChIP_HELA_Human1.39870762
69* SUZ12_27294783_Chip-Seq_NPCs_Mouse1.37074809
70SPI1_23547873_ChIP-Seq_NB4_Human1.35853085
71UTX_26944678_Chip-Seq_JUKART_Human1.35727977
72* NFE2_27457419_Chip-Seq_LIVER_Mouse1.35211089
73RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.33988455
74CDX2_22108803_ChIP-Seq_LS180_Human1.33353446
75WT1_19549856_ChIP-ChIP_CCG9911_Human1.31593571
76TCF4_22108803_ChIP-Seq_LS180_Human1.31181160
77* EZH2_27294783_Chip-Seq_NPCs_Mouse1.29840676
78FOXM1_26456572_ChIP-Seq_MCF-7_Human1.28941611
79* CRX_20693478_ChIP-Seq_RETINA_Mouse1.28343156
80POU3F2_20337985_ChIP-ChIP_501MEL_Human1.28296115
81POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.28233510
82TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.28233510
83FLI1_21867929_ChIP-Seq_TH2_Mouse1.28052117
84NR3C1_21868756_ChIP-Seq_MCF10A_Human1.27885079
85CDX2_19796622_ChIP-Seq_MESCs_Mouse1.27558754
86* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.26692230
87FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.26252491
88* PCGF2_27294783_Chip-Seq_NPCs_Mouse1.25508403
89* RUNX2_22187159_ChIP-Seq_PCA_Human1.24832991
90* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.24739877
91TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.23636105
92BRD4_27068464_Chip-Seq_AML-cells_Mouse1.23584383
93RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.23407125
94IRF1_19129219_ChIP-ChIP_H3396_Human1.23124717
95KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.22750440
96NANOG_19829295_ChIP-Seq_ESCs_Human1.22584213
97SOX2_19829295_ChIP-Seq_ESCs_Human1.22584213
98PKCTHETA_26484144_Chip-Seq_BREAST_Human1.19580828
99RUNX1_22412390_ChIP-Seq_EML_Mouse1.18285827
100GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.16888339
101RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.16442798
102TP53_16413492_ChIP-PET_HCT116_Human1.15524726
103KLF5_20875108_ChIP-Seq_MESCs_Mouse1.14279594
104* SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.12353028
105SPI1_23127762_ChIP-Seq_K562_Human1.12136590
106GATA3_27048872_Chip-Seq_THYMUS_Human1.11940938
107* NANOG_18555785_Chip-Seq_ESCs_Mouse1.10979881
108ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.10842399
109TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.10411215
110* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.09967928
111* E2F1_18555785_Chip-Seq_ESCs_Mouse1.09962991
112* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.09371973
113* SOX2_18555785_Chip-Seq_ESCs_Mouse1.09202972
114GATA2_21666600_ChIP-Seq_HMVEC_Human1.09192465
115PRDM14_20953172_ChIP-Seq_ESCs_Human1.08178659
116TCF4_18268006_ChIP-ChIP_LS174T_Human1.07548271
117VDR_21846776_ChIP-Seq_THP-1_Human1.07316444
118EWS_26573619_Chip-Seq_HEK293_Human1.06865864
119MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.06829709
120GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.06527344
121* PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.06444815
122EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.05490835
123KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.05257917
124KDM2B_26808549_Chip-Seq_REH_Human1.04598762
125FOXA1_21572438_ChIP-Seq_LNCaP_Human1.03900319
126ZNF217_24962896_ChIP-Seq_MCF-7_Human1.02163398
127SMAD4_21741376_ChIP-Seq_EPCs_Human1.01962210
128EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.01809960
129SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.01355713
130ARNT_22903824_ChIP-Seq_MCF-7_Human1.01150537
131* SUZ12_18555785_Chip-Seq_ESCs_Mouse1.00916257
132* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.00422716
133FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.00356650
134AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.00183146
135POU5F1_16153702_ChIP-ChIP_HESCs_Human0.99233216
136* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.97337394
137PADI4_21655091_ChIP-ChIP_MCF-7_Human0.97290126
138TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.96639694
139SOX2_21211035_ChIP-Seq_LN229_Gbm0.96016656
140CTNNB1_20460455_ChIP-Seq_HCT116_Human0.95259854
141* FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.94326832
142* P53_22387025_ChIP-Seq_ESCs_Mouse0.93650040
143CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.93000169
144* OCT4_18555785_Chip-Seq_ESCs_Mouse0.92802868
145* NMYC_18555785_Chip-Seq_ESCs_Mouse0.92724568
146* EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.92427635
147IGF1R_20145208_ChIP-Seq_DFB_Human0.92107803
148* STAT3_18555785_Chip-Seq_ESCs_Mouse0.89666059
149FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.88707786
150* CMYC_18555785_Chip-Seq_ESCs_Mouse0.88609399
151* P300_18555785_Chip-Seq_ESCs_Mouse0.88086902
152SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.88016114
153FUS_26573619_Chip-Seq_HEK293_Human0.86992978
154E2F1_21310950_ChIP-Seq_MCF-7_Human0.85920005
155KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.85058109
156NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.82710930
157* OCT4_21477851_ChIP-Seq_ESCs_Mouse0.82626330
158SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.81731693
159* RUNX1_27457419_Chip-Seq_LIVER_Mouse0.81256692
160MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.80163039

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008877_abnormal_DNA_methylation4.22613098
2MP0002009_preneoplasia3.73064463
3MP0003195_calcinosis3.16062022
4MP0002166_altered_tumor_susceptibility3.00726800
5MP0002254_reproductive_system_inflammat2.71025816
6MP0005174_abnormal_tail_pigmentation2.63541956
7MP0003763_abnormal_thymus_physiology2.61968633
8MP0002006_tumorigenesis2.61584582
9MP0005409_darkened_coat_color2.57252665
10MP0000569_abnormal_digit_pigmentation2.54046840
11MP0002837_dystrophic_cardiac_calcinosis2.48863871
12MP0001835_abnormal_antigen_presentation2.42479432
13MP0002396_abnormal_hematopoietic_system2.40989690
14MP0005671_abnormal_response_to2.39651603
15MP0005379_endocrine/exocrine_gland_phen2.35426551
16MP0001800_abnormal_humoral_immune2.23759837
17MP0004381_abnormal_hair_follicle2.20668766
18MP0000015_abnormal_ear_pigmentation2.18447050
19MP0006072_abnormal_retinal_apoptosis2.17528259
20MP0005645_abnormal_hypothalamus_physiol2.04100815
21MP0000372_irregular_coat_pigmentation2.01984327
22MP0008057_abnormal_DNA_replication2.01468400
23MP0004808_abnormal_hematopoietic_stem2.00405669
24MP0005387_immune_system_phenotype1.97341314
25MP0001790_abnormal_immune_system1.97341314
26MP0005000_abnormal_immune_tolerance1.95498616
27MP0001188_hyperpigmentation1.95190500
28MP0003121_genomic_imprinting1.93958819
29MP0002452_abnormal_antigen_presenting1.93792711
30MP0002163_abnormal_gland_morphology1.91634547
31MP0001984_abnormal_olfaction1.86728830
32MP0002398_abnormal_bone_marrow1.84977269
33MP0002420_abnormal_adaptive_immunity1.84573290
34MP0002723_abnormal_immune_serum1.84460457
35MP0001819_abnormal_immune_cell1.82220987
36MP0003136_yellow_coat_color1.82056903
37MP0009780_abnormal_chondrocyte_physiolo1.81941146
38MP0010234_abnormal_vibrissa_follicle1.77561395
39MP0002102_abnormal_ear_morphology1.77439498
40MP0006292_abnormal_olfactory_placode1.77393402
41MP0000427_abnormal_hair_cycle1.73816788
42MP0005075_abnormal_melanosome_morpholog1.72264537
43MP0000465_gastrointestinal_hemorrhage1.68293960
44MP0003122_maternal_imprinting1.65381467
45MP0005551_abnormal_eye_electrophysiolog1.65339879
46MP0005253_abnormal_eye_physiology1.61845385
47MP0003890_abnormal_embryonic-extraembry1.61075880
48MP0003300_gastrointestinal_ulcer1.60170981
49MP0001873_stomach_inflammation1.59374628
50MP0003786_premature_aging1.59142851
51MP0003436_decreased_susceptibility_to1.59003932
52MP0002419_abnormal_innate_immunity1.58725422
53MP0000716_abnormal_immune_system1.58429909
54MP0002095_abnormal_skin_pigmentation1.57284050
55MP0000703_abnormal_thymus_morphology1.54916478
56MP0010094_abnormal_chromosome_stability1.54715870
57MP0004215_abnormal_myocardial_fiber1.54134063
58MP0000566_synostosis1.53832267
59MP0000685_abnormal_immune_system1.51498948
60MP0002148_abnormal_hypersensitivity_rea1.49327085
61MP0005025_abnormal_response_to1.47681937
62MP0001485_abnormal_pinna_reflex1.42333415
63MP0003724_increased_susceptibility_to1.41703313
64MP0009785_altered_susceptibility_to1.41636668
65MP0005084_abnormal_gallbladder_morpholo1.41134747
66MP0010155_abnormal_intestine_physiology1.40301762
67MP0002722_abnormal_immune_system1.40234350
68MP0005220_abnormal_exocrine_pancreas1.39664897
69MP0000490_abnormal_crypts_of1.39371807
70MP0002405_respiratory_system_inflammati1.37900299
71MP0010307_abnormal_tumor_latency1.36200118
72MP0000689_abnormal_spleen_morphology1.36148586
73MP0006054_spinal_hemorrhage1.34953612
74MP0003303_peritoneal_inflammation1.33746162
75MP0001501_abnormal_sleep_pattern1.33087571
76MP0002693_abnormal_pancreas_physiology1.32964161
77MP0003183_abnormal_peptide_metabolism1.32949703
78MP0000516_abnormal_urinary_system1.29896484
79MP0005367_renal/urinary_system_phenotyp1.29896484
80MP0009333_abnormal_splenocyte_physiolog1.27679469
81MP0005464_abnormal_platelet_physiology1.26966285
82MP0005646_abnormal_pituitary_gland1.26290112
83MP0000383_abnormal_hair_follicle1.25854161
84MP0002429_abnormal_blood_cell1.24621435
85MP0008995_early_reproductive_senescence1.24128671
86MP0002909_abnormal_adrenal_gland1.23122686
87MP0003943_abnormal_hepatobiliary_system1.22897977
88MP0009278_abnormal_bone_marrow1.21615865
89MP0001851_eye_inflammation1.19889564
90MP0005397_hematopoietic_system_phenotyp1.18996837
91MP0001545_abnormal_hematopoietic_system1.18996837
92MP0002877_abnormal_melanocyte_morpholog1.18322949
93MP0005076_abnormal_cell_differentiation1.18313508
94MP0004043_abnormal_pH_regulation1.16742952
95MP0008058_abnormal_DNA_repair1.15805539
96MP0001944_abnormal_pancreas_morphology1.15708387
97MP0002090_abnormal_vision1.11461904
98MP0003111_abnormal_nucleus_morphology1.11012217
99MP0000858_altered_metastatic_potential1.09584031
100MP0008007_abnormal_cellular_replicative1.09541548
101MP0002277_abnormal_respiratory_mucosa1.09083863
102MP0003828_pulmonary_edema1.08357314
103MP0000371_diluted_coat_color1.07695360
104MP0003448_altered_tumor_morphology1.07076067
105MP0003646_muscle_fatigue1.07023935
106MP0003077_abnormal_cell_cycle1.06963430
107MP0009046_muscle_twitch1.05159993
108MP0000631_abnormal_neuroendocrine_gland1.04538875
109MP0004484_altered_response_of1.04336122
110MP0008872_abnormal_physiological_respon1.03860325
111MP0010386_abnormal_urinary_bladder1.03516741
112MP0003787_abnormal_imprinting1.01901985
113MP0004510_myositis0.99820353
114MP0009745_abnormal_behavioral_response0.99752420
115MP0003718_maternal_effect0.99622884
116MP0005310_abnormal_salivary_gland0.98712491
117MP0001486_abnormal_startle_reflex0.97521978
118MP0008260_abnormal_autophagy0.95840007
119MP0009697_abnormal_copulation0.93953897
120MP0003868_abnormal_feces_composition0.93878580
121MP0003045_fibrosis0.93521896
122MP0003693_abnormal_embryo_hatching0.93359665
123MP0003866_abnormal_defecation0.93087858
124MP0002928_abnormal_bile_duct0.93002131
125MP0002751_abnormal_autonomic_nervous0.92977770
126MP0003252_abnormal_bile_duct0.91955670
127MP0002168_other_aberrant_phenotype0.91799588
128MP0002177_abnormal_outer_ear0.91241354
129MP0002075_abnormal_coat/hair_pigmentati0.88597499
130MP0002938_white_spotting0.87600127
131MP0003453_abnormal_keratinocyte_physiol0.87419043
132MP0001845_abnormal_inflammatory_respons0.86481777
133MP0004947_skin_inflammation0.86070683
134MP0005395_other_phenotype0.85836375
135MP0009703_decreased_birth_body0.85815907
136MP0003880_abnormal_central_pattern0.85517480
137MP0001324_abnormal_eye_pigmentation0.85398682
138MP0005248_abnormal_Harderian_gland0.84846620
139MP0010678_abnormal_skin_adnexa0.83665945
140MP0002078_abnormal_glucose_homeostasis0.82097862
141MP0010352_gastrointestinal_tract_polyps0.81986638
142MP0001186_pigmentation_phenotype0.80700562
143MP0002019_abnormal_tumor_incidence0.80469269
144MP0004924_abnormal_behavior0.77793960
145MP0005386_behavior/neurological_phenoty0.77793960
146MP0002998_abnormal_bone_remodeling0.76549535
147MP0001756_abnormal_urination0.76097972
148MP0001853_heart_inflammation0.75216792
149MP0003941_abnormal_skin_development0.72357108
150MP0001346_abnormal_lacrimal_gland0.72162110
151MP0000613_abnormal_salivary_gland0.71710818
152MP0001929_abnormal_gametogenesis0.71111501
153MP0005332_abnormal_amino_acid0.70255586
154MP0003567_abnormal_fetal_cardiomyocyte0.69159488
155MP0002638_abnormal_pupillary_reflex0.68890943
156MP0001533_abnormal_skeleton_physiology0.68281670
157MP0000432_abnormal_head_morphology0.68274461
158MP0000733_abnormal_muscle_development0.68266827
159MP0004133_heterotaxia0.68119784
160MP0004270_analgesia0.68040030
161MP0000350_abnormal_cell_proliferation0.67284642
162MP0002098_abnormal_vibrissa_morphology0.66699493
163MP0001919_abnormal_reproductive_system0.66513326
164MP0002138_abnormal_hepatobiliary_system0.66383829
165MP0000647_abnormal_sebaceous_gland0.66344655
166MP0005389_reproductive_system_phenotype0.66149552
167MP0002557_abnormal_social/conspecific_i0.65744760
168MP0004085_abnormal_heartbeat0.65695210
169MP0002139_abnormal_hepatobiliary_system0.65410184
170MP0002876_abnormal_thyroid_physiology0.63841197
171MP0003172_abnormal_lysosome_physiology0.62915942

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the fingertips (HP:0001211)4.58586244
2Intestinal atresia (HP:0011100)3.76488010
3Hypothermia (HP:0002045)3.42528547
4Stomatitis (HP:0010280)3.30479995
5Neoplasm of the adrenal cortex (HP:0100641)3.20430927
6Aqueductal stenosis (HP:0002410)3.19244808
7Abnormal hair whorl (HP:0010721)3.16863860
8Pancreatic cysts (HP:0001737)3.06388943
9Abnormality of the nasal septum (HP:0000419)3.02995738
10Lip pit (HP:0100267)2.98726707
11Abnormality of the renal cortex (HP:0011035)2.93108654
12Colon cancer (HP:0003003)2.92773912
13Chromsome breakage (HP:0040012)2.91509747
14Recurrent fungal infections (HP:0002841)2.89932557
15Gaze-evoked nystagmus (HP:0000640)2.87000490
16Acute myeloid leukemia (HP:0004808)2.86548533
17Abnormality of the labia minora (HP:0012880)2.83907299
18Agammaglobulinemia (HP:0004432)2.83364646
19Chromosomal breakage induced by crosslinking agents (HP:0003221)2.82572005
20Eczematoid dermatitis (HP:0000976)2.81726190
21Chronic mucocutaneous candidiasis (HP:0002728)2.79782796
22Recurrent cutaneous fungal infections (HP:0011370)2.79782796
23Recurrent abscess formation (HP:0002722)2.79615351
24Pancreatic fibrosis (HP:0100732)2.79229897
25Abnormality of vitamin B metabolism (HP:0004340)2.79094385
26Hyperventilation (HP:0002883)2.78416688
27Prostate neoplasm (HP:0100787)2.73034555
28Mediastinal lymphadenopathy (HP:0100721)2.70061422
29Thyroiditis (HP:0100646)2.69628497
30Ependymoma (HP:0002888)2.67566104
31Abnormality of the astrocytes (HP:0100707)2.67231745
32Astrocytoma (HP:0009592)2.67231745
33Long eyelashes (HP:0000527)2.65459838
34Meningitis (HP:0001287)2.64582239
35Fair hair (HP:0002286)2.64053675
36True hermaphroditism (HP:0010459)2.62168290
37Methylmalonic acidemia (HP:0002912)2.61204198
38Abnormal delayed hypersensitivity skin test (HP:0002963)2.59892728
39Volvulus (HP:0002580)2.56291007
40T lymphocytopenia (HP:0005403)2.54718118
41Recurrent viral infections (HP:0004429)2.54672580
42Pancreatic islet-cell hyperplasia (HP:0004510)2.54222602
43Depressed nasal tip (HP:0000437)2.51022064
44Renal cortical cysts (HP:0000803)2.48387491
45Abnormality of T cell number (HP:0011839)2.42085509
46Glioma (HP:0009733)2.41471946
47Recurrent bacterial skin infections (HP:0005406)2.39309262
48Acute lymphatic leukemia (HP:0006721)2.36559194
49Clubbing of toes (HP:0100760)2.35028078
50Abnormality of midbrain morphology (HP:0002418)2.34240948
51Molar tooth sign on MRI (HP:0002419)2.34240948
52Panhypogammaglobulinemia (HP:0003139)2.33732521
53Rhabdomyosarcoma (HP:0002859)2.33244381
54Ectopic kidney (HP:0000086)2.32043418
55Midline defect of the nose (HP:0004122)2.31863455
56Neoplasm of the adrenal gland (HP:0100631)2.31472390
57IgM deficiency (HP:0002850)2.30742236
58Chronic hepatic failure (HP:0100626)2.29809173
59Prolonged bleeding time (HP:0003010)2.26933386
60Abnormal biliary tract morphology (HP:0012440)2.26520157
61Abnormality of the columella (HP:0009929)2.23576241
62Obstructive lung disease (HP:0006536)2.21556017
63Chronic obstructive pulmonary disease (HP:0006510)2.21556017
64Hamartoma of the eye (HP:0010568)2.20477933
65Medial flaring of the eyebrow (HP:0010747)2.19703689
66Generalized hypopigmentation of hair (HP:0011358)2.17685493
67Nephronophthisis (HP:0000090)2.16315351
68Abnormality of the renal medulla (HP:0100957)2.16217111
69Protruding tongue (HP:0010808)2.15645010
70Progressive inability to walk (HP:0002505)2.14416525
71Spondylolisthesis (HP:0003302)2.14304554
72Optic neuritis (HP:0100653)2.13016525
73Retrobulbar optic neuritis (HP:0100654)2.13016525
74Syringomyelia (HP:0003396)2.12281066
75Spinal cord lesions (HP:0100561)2.12281066
76Oligodactyly (hands) (HP:0001180)2.11672666
77Narrow palate (HP:0000189)2.11649561
78Biliary tract neoplasm (HP:0100574)2.10303016
79Large for gestational age (HP:0001520)2.09865167
80Eosinophilia (HP:0001880)2.09742520
81Neoplasm of the oral cavity (HP:0100649)2.08691497
82Aplasia/Hypoplasia of the fovea (HP:0008060)2.07207342
83Hypoplasia of the fovea (HP:0007750)2.07207342
84Furrowed tongue (HP:0000221)2.07181042
85Attenuation of retinal blood vessels (HP:0007843)2.06388430
86Hyperinsulinemic hypoglycemia (HP:0000825)2.05581204
87Absent frontal sinuses (HP:0002688)2.05438917
88Inflammation of the large intestine (HP:0002037)2.05070242
89Trigonocephaly (HP:0000243)2.04895131
90Transitional cell carcinoma of the bladder (HP:0006740)2.04386710
91Widely spaced teeth (HP:0000687)2.04281942
92Abnormality of eosinophils (HP:0001879)2.03777729
93Severe combined immunodeficiency (HP:0004430)2.03747495
94Broad-based gait (HP:0002136)2.03368780
95Breast carcinoma (HP:0003002)2.02769922
96B lymphocytopenia (HP:0010976)2.02257050
97Abnormality of B cell number (HP:0010975)2.02257050
98Abolished electroretinogram (ERG) (HP:0000550)2.01842586
99Congenital stationary night blindness (HP:0007642)2.00741066
100Febrile seizures (HP:0002373)1.99893566
101Stomach cancer (HP:0012126)1.99774476
102Abnormality of chromosome stability (HP:0003220)1.99356025
103Double outlet right ventricle (HP:0001719)1.99060916
104Congenital malformation of the right heart (HP:0011723)1.99060916
105Anal stenosis (HP:0002025)1.99041657
106Abnormality of the prostate (HP:0008775)1.99035375
107Sparse lateral eyebrow (HP:0005338)1.97972312
108Chronic diarrhea (HP:0002028)1.97239280
109Abnormality of the vitamin B12 metabolism (HP:0004341)1.96473208
110Hematochezia (HP:0002573)1.95929145
111Recurrent skin infections (HP:0001581)1.95208748
112Cellulitis (HP:0100658)1.95016358
113Short 4th metacarpal (HP:0010044)1.94889063
114Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.94889063
115Neoplasm of the tracheobronchial system (HP:0100552)1.94145120
116Hypoproteinemia (HP:0003075)1.93946201
117IgG deficiency (HP:0004315)1.93745636
118Hyperglycemia (HP:0003074)1.93638132
119Abnormality of endocrine pancreas physiology (HP:0012093)1.93183156
120Abnormality of the pancreatic islet cells (HP:0006476)1.93183156
121Abnormality of vitamin metabolism (HP:0100508)1.92091465
122Hemiparesis (HP:0001269)1.91651343
123Myositis (HP:0100614)1.90890495
124Abnormality of the parietal bone (HP:0002696)1.90694253
125Ketoacidosis (HP:0001993)1.89303540
126Hypoglycemic coma (HP:0001325)1.88450531
127Labial hypoplasia (HP:0000066)1.87420252
128Hip dysplasia (HP:0001385)1.86658632
129Leukocytosis (HP:0001974)1.85668739
130Methylmalonic aciduria (HP:0012120)1.85120228
131Supernumerary ribs (HP:0005815)1.84992856
132Abnormality of T cells (HP:0002843)1.84124505
133Hypoglycemic seizures (HP:0002173)1.82596082
134Vasculitis (HP:0002633)1.82434029
135Bladder carcinoma (HP:0002862)1.80305258
136Bladder neoplasm (HP:0009725)1.80305258
137Leiomyosarcoma (HP:0100243)1.79927528
138Uterine leiomyosarcoma (HP:0002891)1.79927528
139Aplasia cutis congenita (HP:0001057)1.79922564
140Gastrointestinal atresia (HP:0002589)1.79822441
141Progressive cerebellar ataxia (HP:0002073)1.79643715
142Granulocytopenia (HP:0001913)1.78786786
143Periodontitis (HP:0000704)1.78670154
144Abnormality of aspartate family amino acid metabolism (HP:0010899)1.77936928
145Alveolar cell carcinoma (HP:0006519)1.77621864
146Gastrointestinal inflammation (HP:0004386)1.77076601
147Sensory axonal neuropathy (HP:0003390)1.74717198
148Abnormality of the fovea (HP:0000493)1.74655800
149Ectropion (HP:0000656)1.74599489
150Lymphopenia (HP:0001888)1.74381417
151Nephroblastoma (Wilms tumor) (HP:0002667)1.74287279
152Gingivitis (HP:0000230)1.73689997
153Macroorchidism (HP:0000053)1.71741223
154Curly hair (HP:0002212)1.71385995
155Sloping forehead (HP:0000340)1.70839112
156Albinism (HP:0001022)1.70804985
157Deep philtrum (HP:0002002)1.70329058
158Urethral obstruction (HP:0000796)1.69925401
159Chronic otitis media (HP:0000389)1.69911807
160Cupped ear (HP:0000378)1.69798062
161Neoplasm of striated muscle (HP:0009728)1.69586650
162Hypoplastic labia majora (HP:0000059)1.69278355
163Hypoplastic female external genitalia (HP:0012815)1.68692519
164Enlarged penis (HP:0000040)1.67777837
165Thyroid carcinoma (HP:0002890)1.67247090
166Abnormal pancreas size (HP:0012094)1.67124191
167Osteomyelitis (HP:0002754)1.66124744
168IgA deficiency (HP:0002720)1.65109629
169Ureteral obstruction (HP:0006000)1.65046235
170Prominent nose (HP:0000448)1.65010096
171Abnormal biliary tract physiology (HP:0012439)1.64872321
172Bile duct proliferation (HP:0001408)1.64872321
173Abnormality of the incisor (HP:0000676)1.64546050
174Supernumerary bones of the axial skeleton (HP:0009144)1.64413454
175Abnormality of cells of the lymphoid lineage (HP:0012140)1.63647791
176Lymphoma (HP:0002665)1.63216305
177Intestinal fistula (HP:0100819)1.62724926
178Embryonal renal neoplasm (HP:0011794)1.62240679
179Arterial thrombosis (HP:0004420)1.61685851
180Congenital sensorineural hearing impairment (HP:0008527)1.61274488
181Colitis (HP:0002583)1.60943667
182Genital tract atresia (HP:0001827)1.60434432
183Gingival bleeding (HP:0000225)1.60276764
184Increased CSF protein (HP:0002922)1.60119051
185Encephalitis (HP:0002383)1.60052165
186Pulmonary infiltrates (HP:0002113)1.60011656
187Ureteral stenosis (HP:0000071)1.59879454
188Abnormality of incisor morphology (HP:0011063)1.59590390
189Meningioma (HP:0002858)1.59417304
190Aplasia/Hypoplasia of the uvula (HP:0010293)1.59157187
191Aplasia/Hypoplasia of the tongue (HP:0010295)1.58789220
192Genetic anticipation (HP:0003743)1.58787647
193Calf muscle hypertrophy (HP:0008981)1.58401595
194Myelodysplasia (HP:0002863)1.57688488

Predicted kinase interactions (KEA)

RankGene SetZ-score
1WNK33.21130191
2NLK3.10604969
3CDK122.89140308
4TXK2.83272917
5ACVR1B2.59918417
6MAP3K142.51860131
7TRIM282.46002171
8MAP4K12.28112505
9IRAK42.11661653
10MKNK22.05435294
11MAP4K21.99330051
12BRD41.88789155
13IRAK31.88285146
14PRKD21.86817875
15PIM11.86076373
16EIF2AK31.85645663
17TEC1.84500176
18CLK11.82505712
19GRK11.81144039
20TAOK31.74858792
21AKT31.72114351
22SGK21.71294790
23FGFR31.70236067
24ERBB31.68566896
25MAP3K41.62982648
26SGK31.59669371
27NUAK11.57117606
28KIT1.54231527
29EIF2AK21.53975121
30STK381.51088913
31CDK91.49974553
32YES11.49891621
33JAK31.48087600
34STK101.46695989
35STK391.46640365
36IKBKE1.45815205
37IKBKB1.44739192
38OXSR11.44691906
39STK31.43350936
40CAMK1D1.42148615
41LATS11.41934674
42PLK31.40924158
43PLK21.40366595
44HIPK21.38818647
45CHUK1.38697377
46CAMK1G1.36438802
47JAK11.34507925
48BRSK21.30932382
49PAK31.28586392
50STK41.27856877
51STK38L1.27655890
52CDK61.26287345
53MKNK11.26147137
54CASK1.24872452
55CDK41.20278919
56TNIK1.16423466
57BTK1.14003753
58EPHB11.12177342
59TRPM71.11581655
60SRPK11.11370269
61ADRBK21.10017294
62FRK1.08179407
63TAF11.07021558
64GRK61.03229266
65ITK1.02709945
66MAPK131.02276286
67PINK11.01158602
68MUSK0.99951138
69FER0.99454094
70TGFBR10.98257327
71TLK10.95119918
72TYK20.94727912
73EPHA30.94616471
74TGFBR20.93037711
75LCK0.90428371
76ZAK0.89205403
77CDK30.87942297
78BCR0.87358224
79HCK0.86753611
80PRKCE0.84290133
81BUB10.83154079
82STK240.82565937
83VRK10.82367149
84FGFR20.81820014
85MELK0.80521679
86CDK80.80374449
87SYK0.78910273
88MAP3K130.78736256
89SGK4940.76140605
90SGK2230.76140605
91DAPK20.75237185
92ZAP700.74766967
93CSK0.73190633
94SIK20.72813765
95DMPK0.72003778
96INSRR0.68229016
97SIK30.65759350
98WNK10.64879359
99STK110.64596538
100CDK70.64384851
101EIF2AK10.60980540
102CSF1R0.60588457
103RIPK40.60532149
104PIK3CA0.60069663
105MARK30.59877650
106LYN0.59599447
107CAMKK20.59357817
108PLK40.59307019
109CSNK1G10.58534570
110PNCK0.57788727
111CHEK20.56944437
112CSNK1G20.56275656
113BMPR1B0.55610571
114OBSCN0.55195363
115PRKAA20.53541304
116PRKCQ0.53177328
117CDC70.52421131
118ATR0.52315174
119ATM0.51697030
120TSSK60.51291578
121MST40.50960863
122IRAK10.50600064
123MAP3K70.49931858
124SGK10.48957782
125MAP3K20.48671680
126TNK20.48363708
127FGFR10.48166466
128NEK90.48065448
129JAK20.47827290
130PTK2B0.47816113
131ABL10.47707730
132CAMK40.47655602
133RPS6KA40.46952148
134RPS6KA50.46270681
135CSNK1A1L0.45344314
136PHKG20.44876198
137PHKG10.44876198
138TIE10.44766812
139MAP2K70.44075629
140CSNK1G30.42877781
141NTRK30.42492198
142PIK3CG0.41005111
143PRKCG0.38483746
144EGFR0.36542637
145PLK10.35058484
146BMPR20.34270919
147PRKG10.34258961
148FLT30.34074230
149ADRBK10.32439096
150MAP3K120.32337484
151PRKAA10.30554112
152DYRK1A0.28134041
153CSNK1D0.26831376

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049503.39874753
2Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.24182047
3Protein export_Homo sapiens_hsa030603.16018634
4Vitamin B6 metabolism_Homo sapiens_hsa007502.54970142
5Primary immunodeficiency_Homo sapiens_hsa053402.41591435
6Propanoate metabolism_Homo sapiens_hsa006402.19582941
7NF-kappa B signaling pathway_Homo sapiens_hsa040642.15776142
8Pantothenate and CoA biosynthesis_Homo sapiens_hsa007702.14433645
9Circadian rhythm_Homo sapiens_hsa047102.10797501
10Intestinal immune network for IgA production_Homo sapiens_hsa046722.00918660
11Butanoate metabolism_Homo sapiens_hsa006502.00906200
12Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.96341199
13Measles_Homo sapiens_hsa051621.93873904
14Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.93142222
15Selenocompound metabolism_Homo sapiens_hsa004501.89646218
16Ether lipid metabolism_Homo sapiens_hsa005651.80264889
17Transcriptional misregulation in cancer_Homo sapiens_hsa052021.73414434
18Leishmaniasis_Homo sapiens_hsa051401.70373769
19Hematopoietic cell lineage_Homo sapiens_hsa046401.66066991
20Graft-versus-host disease_Homo sapiens_hsa053321.63582195
21B cell receptor signaling pathway_Homo sapiens_hsa046621.61953658
22NOD-like receptor signaling pathway_Homo sapiens_hsa046211.57740827
23Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.55510484
24Osteoclast differentiation_Homo sapiens_hsa043801.54625610
25Fanconi anemia pathway_Homo sapiens_hsa034601.51232350
26Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.50151030
27T cell receptor signaling pathway_Homo sapiens_hsa046601.49236640
28Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.47569911
29Herpes simplex infection_Homo sapiens_hsa051681.45999118
30Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.45668778
31Jak-STAT signaling pathway_Homo sapiens_hsa046301.40954442
32Allograft rejection_Homo sapiens_hsa053301.40950197
33Insulin secretion_Homo sapiens_hsa049111.37951086
34Acute myeloid leukemia_Homo sapiens_hsa052211.37663392
35Prostate cancer_Homo sapiens_hsa052151.34236402
36RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.33357686
37Nitrogen metabolism_Homo sapiens_hsa009101.32814169
38RNA polymerase_Homo sapiens_hsa030201.32449632
39Caffeine metabolism_Homo sapiens_hsa002321.32163581
40Toll-like receptor signaling pathway_Homo sapiens_hsa046201.31327061
41Regulation of autophagy_Homo sapiens_hsa041401.27882692
42Linoleic acid metabolism_Homo sapiens_hsa005911.27678070
43Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.27626705
44Small cell lung cancer_Homo sapiens_hsa052221.26534955
45MicroRNAs in cancer_Homo sapiens_hsa052061.25836020
46Hepatitis B_Homo sapiens_hsa051611.25206934
47Antigen processing and presentation_Homo sapiens_hsa046121.24415298
48Taste transduction_Homo sapiens_hsa047421.21543186
49Influenza A_Homo sapiens_hsa051641.20920189
50Toxoplasmosis_Homo sapiens_hsa051451.20039349
51Peroxisome_Homo sapiens_hsa041461.19647436
52Colorectal cancer_Homo sapiens_hsa052101.16943373
53Chronic myeloid leukemia_Homo sapiens_hsa052201.15782829
54Tryptophan metabolism_Homo sapiens_hsa003801.15303694
55Chemokine signaling pathway_Homo sapiens_hsa040621.14506835
56Renin secretion_Homo sapiens_hsa049241.13129879
57Non-homologous end-joining_Homo sapiens_hsa034501.11311099
58Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.10156992
59Type I diabetes mellitus_Homo sapiens_hsa049401.09864357
60Asthma_Homo sapiens_hsa053101.09774608
61ABC transporters_Homo sapiens_hsa020101.09713435
62Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.08262728
63alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.06856081
64Autoimmune thyroid disease_Homo sapiens_hsa053201.06688582
65AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.06468679
66TNF signaling pathway_Homo sapiens_hsa046681.06415968
67Notch signaling pathway_Homo sapiens_hsa043301.04035645
68Serotonergic synapse_Homo sapiens_hsa047261.00534461
69p53 signaling pathway_Homo sapiens_hsa041150.97731785
70Lysine degradation_Homo sapiens_hsa003100.97449984
71Leukocyte transendothelial migration_Homo sapiens_hsa046700.96335054
72Proteasome_Homo sapiens_hsa030500.95506630
73Pancreatic cancer_Homo sapiens_hsa052120.95331468
74Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.95267008
75Platelet activation_Homo sapiens_hsa046110.95060062
76Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.94665249
77Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.94312307
78Cell cycle_Homo sapiens_hsa041100.94264436
79Viral myocarditis_Homo sapiens_hsa054160.94171086
80FoxO signaling pathway_Homo sapiens_hsa040680.93799919
81Homologous recombination_Homo sapiens_hsa034400.93613958
82Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.92368381
83Nicotine addiction_Homo sapiens_hsa050330.91975919
84Tuberculosis_Homo sapiens_hsa051520.91927754
85Basal cell carcinoma_Homo sapiens_hsa052170.90770473
86HTLV-I infection_Homo sapiens_hsa051660.90024515
87Adherens junction_Homo sapiens_hsa045200.89272089
88Primary bile acid biosynthesis_Homo sapiens_hsa001200.88108025
89Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.88027414
90Apoptosis_Homo sapiens_hsa042100.86326867
91Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.84952447
92Viral carcinogenesis_Homo sapiens_hsa052030.84872501
93Malaria_Homo sapiens_hsa051440.84660217
94Pathways in cancer_Homo sapiens_hsa052000.83520685
95Retinol metabolism_Homo sapiens_hsa008300.82304667
96Wnt signaling pathway_Homo sapiens_hsa043100.79254627
97Endometrial cancer_Homo sapiens_hsa052130.79082191
98Other glycan degradation_Homo sapiens_hsa005110.78308963
99Phototransduction_Homo sapiens_hsa047440.77976772
100Long-term depression_Homo sapiens_hsa047300.77818857
101Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.77713023
102Phosphatidylinositol signaling system_Homo sapiens_hsa040700.77449915
103Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.75757800
104Circadian entrainment_Homo sapiens_hsa047130.75732489
105Oocyte meiosis_Homo sapiens_hsa041140.75166925
106Inositol phosphate metabolism_Homo sapiens_hsa005620.74515545
107Glutamatergic synapse_Homo sapiens_hsa047240.74508462
108Dorso-ventral axis formation_Homo sapiens_hsa043200.74222520
109Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.74212929
110One carbon pool by folate_Homo sapiens_hsa006700.73627535
111Salmonella infection_Homo sapiens_hsa051320.73328687
112Epstein-Barr virus infection_Homo sapiens_hsa051690.72935369
113Fatty acid elongation_Homo sapiens_hsa000620.72488959
114Basal transcription factors_Homo sapiens_hsa030220.71451712
115Prolactin signaling pathway_Homo sapiens_hsa049170.71206701
116Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.70143273
117Thyroid hormone signaling pathway_Homo sapiens_hsa049190.69852714
118Regulation of actin cytoskeleton_Homo sapiens_hsa048100.69750394
119Hepatitis C_Homo sapiens_hsa051600.68982766
120Thyroid cancer_Homo sapiens_hsa052160.68711025
121Amphetamine addiction_Homo sapiens_hsa050310.68661460
122Pentose and glucuronate interconversions_Homo sapiens_hsa000400.68567959
123MAPK signaling pathway_Homo sapiens_hsa040100.67810020
124RNA degradation_Homo sapiens_hsa030180.67434240
125Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.67404047
126Non-small cell lung cancer_Homo sapiens_hsa052230.67301447
127Vitamin digestion and absorption_Homo sapiens_hsa049770.66688045
128Pertussis_Homo sapiens_hsa051330.66109001
129Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.65362420
130Steroid hormone biosynthesis_Homo sapiens_hsa001400.64765571
131Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.64258046
132Systemic lupus erythematosus_Homo sapiens_hsa053220.63080360
133Choline metabolism in cancer_Homo sapiens_hsa052310.62739042
134Mineral absorption_Homo sapiens_hsa049780.61306711
135Neurotrophin signaling pathway_Homo sapiens_hsa047220.61219731
136RNA transport_Homo sapiens_hsa030130.60459265
137Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.60259163
138Steroid biosynthesis_Homo sapiens_hsa001000.60227613
139Collecting duct acid secretion_Homo sapiens_hsa049660.59924466
140Purine metabolism_Homo sapiens_hsa002300.58944468
141Sphingolipid metabolism_Homo sapiens_hsa006000.58223918
142Salivary secretion_Homo sapiens_hsa049700.57495123
143African trypanosomiasis_Homo sapiens_hsa051430.56876058
144GABAergic synapse_Homo sapiens_hsa047270.56551618
145Spliceosome_Homo sapiens_hsa030400.55776674
146TGF-beta signaling pathway_Homo sapiens_hsa043500.55627949
147Olfactory transduction_Homo sapiens_hsa047400.55414134
148Dopaminergic synapse_Homo sapiens_hsa047280.55245496
149Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.54205840
150Fatty acid degradation_Homo sapiens_hsa000710.53659005
151Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.52860767
152Shigellosis_Homo sapiens_hsa051310.52358394
153Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.52050961
154Vascular smooth muscle contraction_Homo sapiens_hsa042700.51694726
155Proteoglycans in cancer_Homo sapiens_hsa052050.51646573
156Mismatch repair_Homo sapiens_hsa034300.51624362
157Glucagon signaling pathway_Homo sapiens_hsa049220.51511761
158mRNA surveillance pathway_Homo sapiens_hsa030150.50776062
159Renal cell carcinoma_Homo sapiens_hsa052110.50754260
160Melanoma_Homo sapiens_hsa052180.49899025
161Fatty acid metabolism_Homo sapiens_hsa012120.49712561
162cAMP signaling pathway_Homo sapiens_hsa040240.48411487
163Legionellosis_Homo sapiens_hsa051340.48056706
164cGMP-PKG signaling pathway_Homo sapiens_hsa040220.47872741
165Chemical carcinogenesis_Homo sapiens_hsa052040.47499906
166SNARE interactions in vesicular transport_Homo sapiens_hsa041300.46864581
167Type II diabetes mellitus_Homo sapiens_hsa049300.46841421
168Pancreatic secretion_Homo sapiens_hsa049720.46629085
169Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.45098666
170ErbB signaling pathway_Homo sapiens_hsa040120.44883078
171Ovarian steroidogenesis_Homo sapiens_hsa049130.44757786
172PI3K-Akt signaling pathway_Homo sapiens_hsa041510.44619570
173Tight junction_Homo sapiens_hsa045300.44492058
174Morphine addiction_Homo sapiens_hsa050320.42820996
175Calcium signaling pathway_Homo sapiens_hsa040200.40542452
176Sulfur metabolism_Homo sapiens_hsa009200.39569187
177Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.37507277
178Arachidonic acid metabolism_Homo sapiens_hsa005900.36692140
179Starch and sucrose metabolism_Homo sapiens_hsa005000.36152923
180Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.35046190
181beta-Alanine metabolism_Homo sapiens_hsa004100.33267799

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