INO80E

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)5.10932541
2negative regulation of erythrocyte differentiation (GO:0045647)4.87672242
3positive regulation of type I interferon-mediated signaling pathway (GO:0060340)4.28972107
4antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.28710588
5DNA strand elongation involved in DNA replication (GO:0006271)4.21817572
6DNA replication initiation (GO:0006270)4.18940162
7ribosomal small subunit biogenesis (GO:0042274)4.17573626
8antigen processing and presentation of endogenous antigen (GO:0019883)4.11586226
9telomere maintenance via semi-conservative replication (GO:0032201)4.06871129
10antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.05955670
11viral transcription (GO:0019083)4.01265779
12maturation of SSU-rRNA (GO:0030490)4.00613752
13DNA strand elongation (GO:0022616)3.99494338
14negative regulation of cell killing (GO:0031342)3.88776874
15negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.88776874
16translational termination (GO:0006415)3.87317402
17mannose metabolic process (GO:0006013)3.85832648
18positive thymic T cell selection (GO:0045059)3.82384218
19formation of translation preinitiation complex (GO:0001731)3.74509359
20ribonucleoprotein complex biogenesis (GO:0022613)3.71639384
21DNA replication checkpoint (GO:0000076)3.71428458
22ribosomal large subunit biogenesis (GO:0042273)3.70940342
23ribosomal small subunit assembly (GO:0000028)3.65986754
24positive regulation of gamma-delta T cell activation (GO:0046645)3.60501185
25ribosome biogenesis (GO:0042254)3.59239457
26proteasome assembly (GO:0043248)3.59041807
27DNA unwinding involved in DNA replication (GO:0006268)3.57941083
28spliceosomal snRNP assembly (GO:0000387)3.55954751
29thymic T cell selection (GO:0045061)3.54987247
303-UTR-mediated mRNA stabilization (GO:0070935)3.50909995
31translational initiation (GO:0006413)3.50316136
32telomere maintenance via recombination (GO:0000722)3.49607245
33rRNA processing (GO:0006364)3.49287834
34pseudouridine synthesis (GO:0001522)3.47746779
35antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.44122710
36protein localization to kinetochore (GO:0034501)3.41707841
37regulation of nuclear cell cycle DNA replication (GO:0033262)3.41679174
38translational elongation (GO:0006414)3.41188352
39rRNA metabolic process (GO:0016072)3.39094753
40nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.37324358
41regulation of mammary gland epithelial cell proliferation (GO:0033599)3.35594977
42apoptotic process involved in morphogenesis (GO:0060561)3.34254334
43telomere maintenance via telomere lengthening (GO:0010833)3.33509065
44establishment of integrated proviral latency (GO:0075713)3.28170491
45positive regulation of Cdc42 GTPase activity (GO:0043089)3.27197333
46DNA replication-dependent nucleosome organization (GO:0034723)3.22144908
47DNA replication-dependent nucleosome assembly (GO:0006335)3.22144908
48mitotic recombination (GO:0006312)3.20816702
49SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.20639746
50nucleotide-excision repair, DNA gap filling (GO:0006297)3.20201188
51detection of bacterium (GO:0016045)3.19700708
52negative regulation of cell size (GO:0045792)3.15099196
53kinetochore assembly (GO:0051382)3.14922999
54cotranslational protein targeting to membrane (GO:0006613)3.14868105
55histone arginine methylation (GO:0034969)3.14042823
56mitotic sister chromatid segregation (GO:0000070)3.13602207
57protein targeting to ER (GO:0045047)3.13502639
58cellular protein complex disassembly (GO:0043624)3.12261924
59rRNA modification (GO:0000154)3.08860407
60protein localization to chromosome, centromeric region (GO:0071459)3.08440291
61peptidyl-arginine omega-N-methylation (GO:0035247)3.08241885
62spliceosomal complex assembly (GO:0000245)3.06613766
63viral life cycle (GO:0019058)3.06091371
64negative regulation of myotube differentiation (GO:0010832)3.05845003
65detection of other organism (GO:0098543)3.02023393
66NIK/NF-kappaB signaling (GO:0038061)3.01878658
67maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.00476066
68mitotic metaphase plate congression (GO:0007080)2.99635326
69nucleobase biosynthetic process (GO:0046112)2.98330392
70modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.97879691
71positive regulation by organism of defense response of other organism involved in symbiotic interact2.97879691
72modulation by symbiont of host immune response (GO:0052553)2.97879691
73positive regulation by symbiont of host defense response (GO:0052509)2.97879691
74modulation by symbiont of host defense response (GO:0052031)2.97879691
75modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.97879691
76kinetochore organization (GO:0051383)2.97761765
77viral mRNA export from host cell nucleus (GO:0046784)2.97734178
78establishment of protein localization to endoplasmic reticulum (GO:0072599)2.95504434
79pinocytosis (GO:0006907)2.95129807
80regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.94198179
81regulation of double-strand break repair via homologous recombination (GO:0010569)2.93794174
82protein localization to endoplasmic reticulum (GO:0070972)2.90543374
83transcription-coupled nucleotide-excision repair (GO:0006283)2.89169725
84regulation of gene silencing by RNA (GO:0060966)2.88561277
85regulation of posttranscriptional gene silencing (GO:0060147)2.88561277
86regulation of gene silencing by miRNA (GO:0060964)2.88561277
87histone H4-K12 acetylation (GO:0043983)2.87539358
88protein complex disassembly (GO:0043241)2.87416475
89negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.87350176
90T cell selection (GO:0045058)2.87135587
91termination of RNA polymerase II transcription (GO:0006369)2.86762379
92transcription elongation from RNA polymerase III promoter (GO:0006385)2.86443877
93termination of RNA polymerase III transcription (GO:0006386)2.86443877
94proline biosynthetic process (GO:0006561)2.86295550
95translation (GO:0006412)2.84907382
96regulation of type I interferon-mediated signaling pathway (GO:0060338)2.84608247
97maturation of 5.8S rRNA (GO:0000460)2.84551085
98ribosome assembly (GO:0042255)2.83380192
99regulation of gamma-delta T cell differentiation (GO:0045586)2.83263633
100leukocyte aggregation (GO:0070486)2.82679269
101cell-substrate adherens junction assembly (GO:0007045)2.82498155
102focal adhesion assembly (GO:0048041)2.82498155
103exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.82340084
104RNA splicing, via transesterification reactions (GO:0000375)2.81785145
105protein localization to endosome (GO:0036010)2.81737894
106maternal placenta development (GO:0001893)2.81587151
107mitotic nuclear envelope disassembly (GO:0007077)2.81268782
108RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.80827686
109mRNA splicing, via spliceosome (GO:0000398)2.80827686
110adherens junction assembly (GO:0034333)2.80781508
111response to laminar fluid shear stress (GO:0034616)2.80689273
112pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.79713940
113CENP-A containing nucleosome assembly (GO:0034080)2.79193925
114IMP biosynthetic process (GO:0006188)2.78834813
115modulation by virus of host process (GO:0019054)2.78469586
116somatic hypermutation of immunoglobulin genes (GO:0016446)2.78288660
117somatic diversification of immune receptors via somatic mutation (GO:0002566)2.78288660
118intracellular estrogen receptor signaling pathway (GO:0030520)2.78030940
119nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.77988155
120cellular response to virus (GO:0098586)2.77389148
121regulation of gamma-delta T cell activation (GO:0046643)2.76500593
122regulation of extracellular matrix disassembly (GO:0010715)2.75275809
123chromatin remodeling at centromere (GO:0031055)2.75057681
124nuclear-transcribed mRNA catabolic process (GO:0000956)2.74994744
125replication fork processing (GO:0031297)2.74722029
126modulation by symbiont of host cellular process (GO:0044068)2.74593275
127negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.73523744
128negative regulation of telomere maintenance (GO:0032205)2.73341092
129GDP-mannose metabolic process (GO:0019673)2.73044253
130ncRNA processing (GO:0034470)2.72208222
131macromolecular complex disassembly (GO:0032984)2.69934095
132positive T cell selection (GO:0043368)2.69927352
133COPI coating of Golgi vesicle (GO:0048205)2.68923002
134Golgi transport vesicle coating (GO:0048200)2.68923002
135regulation of necroptotic process (GO:0060544)2.68852068
136DNA-templated transcription, termination (GO:0006353)2.68072744
137negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.67595288
138anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.67260777
139negative regulation of necroptotic process (GO:0060546)2.67058655
140cellular component biogenesis (GO:0044085)2.66341534
141base-excision repair (GO:0006284)2.66080173
142negative regulation of RNA splicing (GO:0033119)2.65643144
143embryonic process involved in female pregnancy (GO:0060136)2.65620302
144regulation of telomere maintenance via telomerase (GO:0032210)2.65170209
145response to muramyl dipeptide (GO:0032495)2.64955256
146negative thymic T cell selection (GO:0045060)2.64734323
147regulation of necrotic cell death (GO:0010939)2.64658644
148B cell receptor signaling pathway (GO:0050853)2.64618154
149folic acid-containing compound biosynthetic process (GO:0009396)2.64583921
150ncRNA metabolic process (GO:0034660)2.62152755
151mRNA catabolic process (GO:0006402)2.61393706
152positive regulation of histone deacetylation (GO:0031065)2.61150307
153negative regulation of mRNA processing (GO:0050686)2.61142172
154DNA replication-independent nucleosome assembly (GO:0006336)2.60993524
155DNA replication-independent nucleosome organization (GO:0034724)2.60993524
156RNA catabolic process (GO:0006401)2.60886956
157spliceosomal tri-snRNP complex assembly (GO:0000244)2.60533390
158base-excision repair, AP site formation (GO:0006285)2.60426882
159response to peptidoglycan (GO:0032494)2.60282765
160regulation of histone H3-K27 methylation (GO:0061085)2.59568048
161DNA duplex unwinding (GO:0032508)2.57295804
162regulation of glucose import in response to insulin stimulus (GO:2001273)2.56732120
163negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.54260799
164RNA stabilization (GO:0043489)2.53649934
165mRNA stabilization (GO:0048255)2.53649934
166negative regulation of phagocytosis (GO:0050765)2.53393633
167negative regulation of viral release from host cell (GO:1902187)2.53191506
168antigen processing and presentation via MHC class Ib (GO:0002475)2.52821387
169regulation of early endosome to late endosome transport (GO:2000641)2.52814011
170barbed-end actin filament capping (GO:0051016)2.52617013
171pentose-phosphate shunt (GO:0006098)2.52516936
172regulation of defense response to virus by virus (GO:0050690)2.46287127
173negative T cell selection (GO:0043383)2.45717814
174regulation of chromatin binding (GO:0035561)2.45504594
175retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.44732500
176detection of external biotic stimulus (GO:0098581)2.42711474
177cellular hyperosmotic response (GO:0071474)2.42558309
178regulation of leukocyte degranulation (GO:0043300)2.41980330
179UV protection (GO:0009650)2.40500418
180activation of Rac GTPase activity (GO:0032863)2.40059648
181activation of MAPKKK activity (GO:0000185)2.39568654
182regulation of ARF GTPase activity (GO:0032312)2.39197302
183regulation of superoxide anion generation (GO:0032928)2.39083827
184epithelial cell differentiation involved in prostate gland development (GO:0060742)2.38760457
185regulation of interferon-beta biosynthetic process (GO:0045357)2.37989606
186negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.37945855
187protein retention in ER lumen (GO:0006621)2.37625993
188histone H4 deacetylation (GO:0070933)2.36108122
189immunoglobulin mediated immune response (GO:0016064)2.34762620
190regulation of monocyte differentiation (GO:0045655)2.33236696
191positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling2.31620472
192lymph vessel development (GO:0001945)2.31106719
193activation of JUN kinase activity (GO:0007257)2.30412048
194regulation of myeloid leukocyte mediated immunity (GO:0002886)2.29965956
195cellular response to interleukin-4 (GO:0071353)2.29163635
196macrophage activation involved in immune response (GO:0002281)2.26831393
197positive regulation of blood vessel endothelial cell migration (GO:0043536)2.26578190

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.48532934
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.23438808
3FOXM1_23109430_ChIP-Seq_U2OS_Human3.58048092
4E2F4_17652178_ChIP-ChIP_JURKAT_Human3.33424881
5EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.33008286
6MYC_19079543_ChIP-ChIP_MESCs_Mouse3.19876335
7EST1_17652178_ChIP-ChIP_JURKAT_Human2.98723724
8KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.97493569
9FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.92820021
10* ETS1_20019798_ChIP-Seq_JURKAT_Human2.88462816
11MYC_18358816_ChIP-ChIP_MESCs_Mouse2.86969517
12JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.86155363
13MYC_19030024_ChIP-ChIP_MESCs_Mouse2.85508090
14NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.81876513
15LXR_22292898_ChIP-Seq_THP-1_Human2.79378033
16GABP_17652178_ChIP-ChIP_JURKAT_Human2.66670011
17THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.55793198
18HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.54758218
19ELK3_25401928_ChIP-Seq_HUVEC_Human2.43429811
20KDM2B_26808549_Chip-Seq_SUP-B15_Human2.40233406
21MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.38162798
22XRN2_22483619_ChIP-Seq_HELA_Human2.36485548
23KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.35885077
24CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.29236901
25CREB1_15753290_ChIP-ChIP_HEK293T_Human2.27867463
26NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.17158565
27KDM2B_26808549_Chip-Seq_DND41_Human2.09984438
28TCF7_22412390_ChIP-Seq_EML_Mouse2.09129932
29VDR_23849224_ChIP-Seq_CD4+_Human2.09038401
30MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.08239689
31RACK7_27058665_Chip-Seq_MCF-7_Human2.06894791
32E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.05868101
33RARG_19884340_ChIP-ChIP_MEFs_Mouse2.03677269
34NELFA_20434984_ChIP-Seq_ESCs_Mouse2.00916606
35YY1_21170310_ChIP-Seq_MESCs_Mouse2.00336189
36PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.00305456
37TP63_19390658_ChIP-ChIP_HaCaT_Human2.00002025
38NANOG_18555785_ChIP-Seq_MESCs_Mouse1.99334045
39SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.98263031
40NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.98181886
41THAP11_20581084_ChIP-Seq_MESCs_Mouse1.97218006
42FOXP3_21729870_ChIP-Seq_TREG_Human1.93078362
43KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.92793703
44KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.92793703
45KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.92793703
46SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.92146914
47DCP1A_22483619_ChIP-Seq_HELA_Human1.87163716
48HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.84134798
49E2F1_18555785_ChIP-Seq_MESCs_Mouse1.83404237
50* TTF2_22483619_ChIP-Seq_HELA_Human1.83125362
51POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.82607308
52MAF_26560356_Chip-Seq_TH1_Human1.82605150
53VDR_24763502_ChIP-Seq_THP-1_Human1.81913845
54ELF1_17652178_ChIP-ChIP_JURKAT_Human1.81656777
55TP63_17297297_ChIP-ChIP_HaCaT_Human1.81101781
56TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.78922274
57MYC_22102868_ChIP-Seq_BL_Human1.74661217
58CIITA_25753668_ChIP-Seq_RAJI_Human1.74081997
59TET1_21451524_ChIP-Seq_MESCs_Mouse1.73404193
60EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.72874727
61* P68_20966046_ChIP-Seq_HELA_Human1.71974364
62GABP_19822575_ChIP-Seq_HepG2_Human1.71590763
63MYCN_18555785_ChIP-Seq_MESCs_Mouse1.68803529
64SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.68720838
65KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.68379396
66MAF_26560356_Chip-Seq_TH2_Human1.68245045
67UTX_26944678_Chip-Seq_JUKART_Human1.68012718
68ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.63637810
69E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.60814788
70NOTCH1_21737748_ChIP-Seq_TLL_Human1.60736138
71SA1_27219007_Chip-Seq_ERYTHROID_Human1.59280601
72E2F1_21310950_ChIP-Seq_MCF-7_Human1.58008178
73TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.57816222
74CTCF_27219007_Chip-Seq_ERYTHROID_Human1.57637045
75VDR_21846776_ChIP-Seq_THP-1_Human1.55185188
76CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.53009973
77KDM2B_26808549_Chip-Seq_K562_Human1.48424358
78POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.47989044
79RUNX1_22412390_ChIP-Seq_EML_Mouse1.45795058
80YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.44685142
81STAT6_21828071_ChIP-Seq_BEAS2B_Human1.44546582
82KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.43102275
83POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.42744857
84ELF1_20517297_ChIP-Seq_JURKAT_Human1.42269722
85KDM2B_26808549_Chip-Seq_JURKAT_Human1.42203988
86* SMC4_20622854_ChIP-Seq_HELA_Human1.41354693
87RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.40118947
88MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.39163753
89CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.37620898
90MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.37421883
91EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.35699621
92BRD4_27068464_Chip-Seq_AML-cells_Mouse1.35660833
93BCOR_27268052_Chip-Seq_Bcells_Human1.35282393
94KDM5A_27292631_Chip-Seq_BREAST_Human1.34825846
95ZNF263_19887448_ChIP-Seq_K562_Human1.34587668
96IRF8_22096565_ChIP-ChIP_GC-B_Human1.33885177
97UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.33450933
98ZFP281_18757296_ChIP-ChIP_E14_Mouse1.33249644
99ELK1_19687146_ChIP-ChIP_HELA_Human1.32472292
100EGR1_19374776_ChIP-ChIP_THP-1_Human1.32383701
101* BCL6_27268052_Chip-Seq_Bcells_Human1.31110225
102CREB1_26743006_Chip-Seq_LNCaP_Human1.28661350
103DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.27783457
104SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.27439474
105NCOR1_26117541_ChIP-Seq_K562_Human1.26971645
106KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.25735260
107FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.24687216
108KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.24338986
109GATA1_22383799_ChIP-Seq_G1ME_Mouse1.23878534
110ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.23846176
111KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.22583363
112AR_21909140_ChIP-Seq_LNCAP_Human1.22362099
113STAT3_1855785_ChIP-Seq_MESCs_Mouse1.22167018
114PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.22023667
115SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.21330311
116PU.1_20513432_ChIP-Seq_Bcells_Mouse1.20977695
117FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.20658914
118SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.20529268
119ERG_21242973_ChIP-ChIP_JURKAT_Human1.19136225
120SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.19068834
121KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.18694001
122SOX2_18555785_ChIP-Seq_MESCs_Mouse1.17692942
123ZFX_18555785_ChIP-Seq_MESCs_Mouse1.17106205
124CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.16777857
125TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.16154915
126DNAJC2_21179169_ChIP-ChIP_NT2_Human1.15555438
127ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.14923781
128NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.14772320
129BP1_19119308_ChIP-ChIP_Hs578T_Human1.14288690
130CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.12990237
131SRF_21415370_ChIP-Seq_HL-1_Mouse1.12880106
132TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.12613177
133TCF3_18692474_ChIP-Seq_MEFs_Mouse1.12565102
134P300_27058665_Chip-Seq_ZR-75-30cells_Human1.12429168
135HOXB4_20404135_ChIP-ChIP_EML_Mouse1.12016553
136MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.10735360
137RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.10561728
138SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.10380601
139NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.10365173
140CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.09337227
141PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.09186237
142CTCF_26484167_Chip-Seq_Bcells_Mouse1.08869949
143NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.08099841
144NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.07934507
145PPARA_22158963_ChIP-Seq_LIVER_Mouse1.06850803
146SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.06149552
147CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.05492459
148KLF4_18555785_ChIP-Seq_MESCs_Mouse1.05475654
149GATA1_19941827_ChIP-Seq_MEL_Mouse1.05426398
150TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.04741719
151PHF8_20622854_ChIP-Seq_HELA_Human1.04331793
152* SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.04044557
153ESR2_21235772_ChIP-Seq_MCF-7_Human1.03563434
154TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.03559536
155ERG_20887958_ChIP-Seq_HPC-7_Mouse1.03478871
156MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.03045636
157STAT4_19710469_ChIP-ChIP_TH1__Mouse1.01920328
158CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.01261693
159ATF3_27146783_Chip-Seq_COLON_Human1.01216773
160ETS1_21867929_ChIP-Seq_TH2_Mouse1.00976152
161CTCF_21964334_Chip-Seq_Bcells_Human1.00844693
162* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.99871722
163SPI1_23547873_ChIP-Seq_NB4_Human0.99019851
164ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.98768430
165* SRY_22984422_ChIP-ChIP_TESTIS_Rat0.97498972
166TCF3_18692474_ChIP-Seq_MESCs_Mouse0.96978839
167TFEB_21752829_ChIP-Seq_HELA_Human0.96624284
168SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.94820743
169ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.94688687
170BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.92566946
171DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.92343507
172CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.91577577
173TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.91008332
174OCT4_18692474_ChIP-Seq_MEFs_Mouse0.89162952
175GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.89109011
176CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.88011207
177MYC_18940864_ChIP-ChIP_HL60_Human0.87093951
178SOX2_18692474_ChIP-Seq_MEFs_Mouse0.86725775
179POU5F1_18692474_ChIP-Seq_MESCs_Mouse0.86151380
180ELK1_22589737_ChIP-Seq_MCF10A_Human0.86074368

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.19393056
2MP0003111_abnormal_nucleus_morphology4.11219795
3MP0008057_abnormal_DNA_replication3.97192784
4MP0004957_abnormal_blastocyst_morpholog3.58800987
5MP0010094_abnormal_chromosome_stability3.51663348
6MP0003705_abnormal_hypodermis_morpholog3.41327134
7MP0003077_abnormal_cell_cycle3.27141966
8MP0005451_abnormal_body_composition3.08651142
9MP0003436_decreased_susceptibility_to3.00358265
10MP0008058_abnormal_DNA_repair2.93804784
11MP0008932_abnormal_embryonic_tissue2.72486028
12MP0010030_abnormal_orbit_morphology2.58949715
13MP0003303_peritoneal_inflammation2.57603697
14MP0005058_abnormal_lysosome_morphology2.48624151
15MP0008260_abnormal_autophagy2.44053505
16MP0000678_abnormal_parathyroid_gland2.21178413
17MP0006292_abnormal_olfactory_placode2.19590432
18MP0000566_synostosis2.19117792
19MP0008007_abnormal_cellular_replicative2.10815872
20MP0002396_abnormal_hematopoietic_system2.07045983
21MP0004858_abnormal_nervous_system2.02814259
22MP0003786_premature_aging1.98429377
23MP0001849_ear_inflammation1.95471295
24MP0000350_abnormal_cell_proliferation1.92774461
25MP0004185_abnormal_adipocyte_glucose1.91710609
26MP0003191_abnormal_cellular_cholesterol1.87860586
27MP0004133_heterotaxia1.81456636
28MP0003172_abnormal_lysosome_physiology1.81145830
29MP0000490_abnormal_crypts_of1.77265118
30MP0005025_abnormal_response_to1.73843793
31MP0003300_gastrointestinal_ulcer1.72336924
32MP0001835_abnormal_antigen_presentation1.70238879
33MP0009840_abnormal_foam_cell1.66859986
34MP0001730_embryonic_growth_arrest1.66369649
35MP0001790_abnormal_immune_system1.65144533
36MP0005387_immune_system_phenotype1.65144533
37MP0004947_skin_inflammation1.62005252
38MP0002877_abnormal_melanocyte_morpholog1.61627672
39MP0008877_abnormal_DNA_methylation1.55863370
40MP0001293_anophthalmia1.55558263
41MP0005000_abnormal_immune_tolerance1.54366452
42MP0003566_abnormal_cell_adhesion1.52836490
43MP0005666_abnormal_adipose_tissue1.52110689
44MP0002102_abnormal_ear_morphology1.52053938
45MP0002419_abnormal_innate_immunity1.50022214
46MP0003136_yellow_coat_color1.49342748
47MP0010155_abnormal_intestine_physiology1.48601840
48MP0009333_abnormal_splenocyte_physiolog1.44185545
49MP0002085_abnormal_embryonic_tissue1.42634873
50MP0001672_abnormal_embryogenesis/_devel1.38087291
51MP0005380_embryogenesis_phenotype1.38087291
52MP0000313_abnormal_cell_death1.38015074
53MP0003718_maternal_effect1.37670003
54MP0001697_abnormal_embryo_size1.36642033
55MP0005409_darkened_coat_color1.35826343
56MP0001873_stomach_inflammation1.34745941
57MP0010352_gastrointestinal_tract_polyps1.34524427
58MP0005360_urolithiasis1.34015047
59MP0003123_paternal_imprinting1.33806440
60MP0003453_abnormal_keratinocyte_physiol1.33723263
61MP0003763_abnormal_thymus_physiology1.31278251
62MP0005375_adipose_tissue_phenotype1.30833652
63MP0003866_abnormal_defecation1.30357129
64MP0000703_abnormal_thymus_morphology1.30261805
65MP0003724_increased_susceptibility_to1.29193440
66MP0001533_abnormal_skeleton_physiology1.26921585
67MP0002080_prenatal_lethality1.26694189
68MP0002084_abnormal_developmental_patter1.26284825
69MP0004381_abnormal_hair_follicle1.26276725
70MP0001348_abnormal_lacrimal_gland1.26144819
71MP0000049_abnormal_middle_ear1.25919995
72MP0002653_abnormal_ependyma_morphology1.23534648
73MP0009278_abnormal_bone_marrow1.22591188
74MP0003091_abnormal_cell_migration1.22429476
75MP0003938_abnormal_ear_development1.21534687
76MP0002019_abnormal_tumor_incidence1.20693881
77MP0000003_abnormal_adipose_tissue1.19973202
78MP0003880_abnormal_central_pattern1.19629043
79MP0003941_abnormal_skin_development1.19315951
80MP0005075_abnormal_melanosome_morpholog1.18465045
81MP0005464_abnormal_platelet_physiology1.18449840
82MP0002249_abnormal_larynx_morphology1.16483622
83MP0003984_embryonic_growth_retardation1.15307551
84MP0002398_abnormal_bone_marrow1.14833211
85MP0003279_aneurysm1.14503444
86MP0002751_abnormal_autonomic_nervous1.13709480
87MP0005670_abnormal_white_adipose1.12350122
88MP0002132_abnormal_respiratory_system1.11780983
89MP0002088_abnormal_embryonic_growth/wei1.11049661
90MP0005423_abnormal_somatic_nervous1.10996627
91MP0002722_abnormal_immune_system1.08972177
92MP0003119_abnormal_digestive_system1.08237383
93MP0009785_altered_susceptibility_to1.04870895
94MP0003121_genomic_imprinting1.04482211
95MP0002086_abnormal_extraembryonic_tissu1.04411017
96MP0001545_abnormal_hematopoietic_system1.04338956
97MP0005397_hematopoietic_system_phenotyp1.04338956
98MP0002933_joint_inflammation1.04189132
99MP0004197_abnormal_fetal_growth/weight/1.03204645
100MP0010307_abnormal_tumor_latency1.03168738
101MP0005174_abnormal_tail_pigmentation1.02584609
102MP0002210_abnormal_sex_determination1.01930338
103MP0004808_abnormal_hematopoietic_stem1.01331373
104MP0000689_abnormal_spleen_morphology1.01013413
105MP0001188_hyperpigmentation1.00899207
106MP0004510_myositis1.00842532
107MP0001958_emphysema1.00068880
108MP0002796_impaired_skin_barrier0.99487001
109MP0003890_abnormal_embryonic-extraembry0.99194202
110MP0008438_abnormal_cutaneous_collagen0.98885975
111MP0000733_abnormal_muscle_development0.98863177
112MP0003183_abnormal_peptide_metabolism0.96996809
113MP0002998_abnormal_bone_remodeling0.96847936
114MP0003315_abnormal_perineum_morphology0.96608438
115MP0000685_abnormal_immune_system0.96322477
116MP0000681_abnormal_thyroid_gland0.95282694
117MP0001845_abnormal_inflammatory_respons0.94560231
118MP0001145_abnormal_male_reproductive0.93779097
119MP0005623_abnormal_meninges_morphology0.90964338
120MP0000015_abnormal_ear_pigmentation0.89978129
121MP0009379_abnormal_foot_pigmentation0.89743486
122MP0000858_altered_metastatic_potential0.88828787
123MP0002089_abnormal_postnatal_growth/wei0.88679112
124MP0005023_abnormal_wound_healing0.88158270
125MP0001286_abnormal_eye_development0.87091639
126MP0005501_abnormal_skin_physiology0.86460019
127MP0002429_abnormal_blood_cell0.86416042
128MP0000767_abnormal_smooth_muscle0.86397494
129MP0002111_abnormal_tail_morphology0.86126406
130MP0000716_abnormal_immune_system0.84355828
131MP0005621_abnormal_cell_physiology0.84341254
132MP0000428_abnormal_craniofacial_morphol0.83681619
133MP0002405_respiratory_system_inflammati0.82580437
134MP0008469_abnormal_protein_level0.82358247
135MP0002166_altered_tumor_susceptibility0.82287785
136MP0001800_abnormal_humoral_immune0.81905425
137MP0000477_abnormal_intestine_morphology0.80947604
138MP0005257_abnormal_intraocular_pressure0.80564525
139MP0002277_abnormal_respiratory_mucosa0.80082133
140MP0001727_abnormal_embryo_implantation0.79955738
141MP0001929_abnormal_gametogenesis0.79284707
142MP0004264_abnormal_extraembryonic_tissu0.78069557
143MP0003075_altered_response_to0.76464655
144MP0009931_abnormal_skin_appearance0.76412223
145MP0002970_abnormal_white_adipose0.75701296
146MP0005166_decreased_susceptibility_to0.75633890
147MP0004233_abnormal_muscle_weight0.75381398
148MP0001851_eye_inflammation0.74505964
149MP0005390_skeleton_phenotype0.74099232
150MP0002092_abnormal_eye_morphology0.73896468
151MP0010234_abnormal_vibrissa_follicle0.73379674
152MP0003861_abnormal_nervous_system0.73226029
153MP0003828_pulmonary_edema0.72898426
154MP0002420_abnormal_adaptive_immunity0.71799120
155MP0002452_abnormal_antigen_presenting0.70686065
156MP0001819_abnormal_immune_cell0.70615019
157MP0000762_abnormal_tongue_morphology0.69626883
158MP0008995_early_reproductive_senescence0.68067210
159MP0002160_abnormal_reproductive_system0.67900848
160MP0003937_abnormal_limbs/digits/tail_de0.67756864
161MP0000653_abnormal_sex_gland0.67293170
162MP0003755_abnormal_palate_morphology0.66929906
163MP0002114_abnormal_axial_skeleton0.66877578
164MP0005076_abnormal_cell_differentiation0.65801110
165MP0002075_abnormal_coat/hair_pigmentati0.64877012
166MP0001919_abnormal_reproductive_system0.64763369
167MP0002723_abnormal_immune_serum0.64081232
168MP0005671_abnormal_response_to0.63052216
169MP0003448_altered_tumor_morphology0.62789687
170MP0005384_cellular_phenotype0.62365487

Predicted human phenotypes

RankGene SetZ-score
1Reticulocytopenia (HP:0001896)4.22704148
2Chromosomal breakage induced by crosslinking agents (HP:0003221)3.94122401
3Birth length less than 3rd percentile (HP:0003561)3.83961185
4Eczematoid dermatitis (HP:0000976)3.83398994
5Abnormality of cells of the erythroid lineage (HP:0012130)3.77831841
6Breast hypoplasia (HP:0003187)3.77026891
7Absent radius (HP:0003974)3.72184411
8Abnormal number of erythroid precursors (HP:0012131)3.67391968
9Chromsome breakage (HP:0040012)3.62452602
10Aplasia involving forearm bones (HP:0009822)3.51031697
11Absent forearm bone (HP:0003953)3.51031697
12Cellulitis (HP:0100658)3.07782389
13Colitis (HP:0002583)3.03158602
14Duplicated collecting system (HP:0000081)2.98820394
15Patellar aplasia (HP:0006443)2.95986953
16Hyperacusis (HP:0010780)2.94400698
17Abnormality of the ileum (HP:0001549)2.93922443
18Absent thumb (HP:0009777)2.91507597
19Meckel diverticulum (HP:0002245)2.90231705
20Broad face (HP:0000283)2.80365658
21Aplasia/Hypoplasia of the sacrum (HP:0008517)2.79360657
22Pallor (HP:0000980)2.76865424
23Aplasia/Hypoplasia of the patella (HP:0006498)2.76614777
24Cerebral hypomyelination (HP:0006808)2.75823706
25Duplication of thumb phalanx (HP:0009942)2.72412583
26Gastrointestinal inflammation (HP:0004386)2.68583347
27Obstructive sleep apnea (HP:0002870)2.68326070
28Partial duplication of thumb phalanx (HP:0009944)2.66262974
29Recurrent abscess formation (HP:0002722)2.65447237
30Abnormality of the preputium (HP:0100587)2.64618825
31Hemorrhage of the eye (HP:0011885)2.63881440
32Triphalangeal thumb (HP:0001199)2.62813533
33Aplasia/Hypoplasia of the uvula (HP:0010293)2.62739160
34Recurrent bacterial skin infections (HP:0005406)2.61002317
35Abnormal number of incisors (HP:0011064)2.59169401
36Abnormality of the fingertips (HP:0001211)2.56525650
37Supernumerary spleens (HP:0009799)2.55401942
38Protrusio acetabuli (HP:0003179)2.53422285
39Vertebral compression fractures (HP:0002953)2.51006108
40Selective tooth agenesis (HP:0001592)2.50893956
41Chronic obstructive pulmonary disease (HP:0006510)2.50285400
42Obstructive lung disease (HP:0006536)2.50285400
43Macrocytic anemia (HP:0001972)2.49582055
44Increased IgE level (HP:0003212)2.47433971
45Abnormality of the labia minora (HP:0012880)2.46323695
46Concave nail (HP:0001598)2.46111409
47Trismus (HP:0000211)2.45266531
48Abnormality of the renal collecting system (HP:0004742)2.43215329
49Emphysema (HP:0002097)2.40747215
50Rib fusion (HP:0000902)2.40140784
51Abnormality of the anterior horn cell (HP:0006802)2.38678459
52Degeneration of anterior horn cells (HP:0002398)2.38678459
53Thin bony cortex (HP:0002753)2.38539783
54Deep venous thrombosis (HP:0002625)2.38016543
55Ragged-red muscle fibers (HP:0003200)2.36612199
56Inflammation of the large intestine (HP:0002037)2.34017262
57Premature ovarian failure (HP:0008209)2.33664281
58Partial duplication of the phalanx of hand (HP:0009999)2.33503408
59Cerebral aneurysm (HP:0004944)2.32906190
60Increased connective tissue (HP:0009025)2.30784669
61Rough bone trabeculation (HP:0100670)2.29245734
62Gastrointestinal stroma tumor (HP:0100723)2.27945300
63Mediastinal lymphadenopathy (HP:0100721)2.27860378
64Broad distal phalanx of finger (HP:0009836)2.27818124
65Abnormality of macrophages (HP:0004311)2.27477227
66Small intestinal stenosis (HP:0012848)2.25693149
67Duodenal stenosis (HP:0100867)2.25693149
68Meningitis (HP:0001287)2.24426724
69Asplenia (HP:0001746)2.23929551
70Agammaglobulinemia (HP:0004432)2.23042323
71Polygenic inheritance (HP:0010982)2.22929948
72Gastrointestinal infarctions (HP:0005244)2.22817789
73Gingivitis (HP:0000230)2.21891764
74Malnutrition (HP:0004395)2.21761448
75Hypoplasia of the radius (HP:0002984)2.20698544
76Agnosia (HP:0010524)2.20602147
77Horseshoe kidney (HP:0000085)2.20268869
78Abnormality of chromosome stability (HP:0003220)2.19603382
79Premature graying of hair (HP:0002216)2.19507897
80Rectal prolapse (HP:0002035)2.19498204
81Bone marrow hypocellularity (HP:0005528)2.19468679
82Hypertensive crisis (HP:0100735)2.19178759
83Distal lower limb amyotrophy (HP:0008944)2.18937197
84Recurrent gram-negative bacterial infections (HP:0005420)2.18108488
85Ependymoma (HP:0002888)2.17349349
86Medulloblastoma (HP:0002885)2.15741003
87Ulnar bowing (HP:0003031)2.15275900
88Segmental peripheral demyelination/remyelination (HP:0003481)2.14778903
89Atresia of the external auditory canal (HP:0000413)2.14150140
90Disproportionate tall stature (HP:0001519)2.14132430
91Myelodysplasia (HP:0002863)2.13743479
92Abnormality of the nasal mucosa (HP:0000433)2.13643233
93Centrally nucleated skeletal muscle fibers (HP:0003687)2.13495622
94Stridor (HP:0010307)2.13090183
95Achilles tendon contracture (HP:0001771)2.12391910
96Carpal bone hypoplasia (HP:0001498)2.12164274
97Rectovaginal fistula (HP:0000143)2.12042518
98Rectal fistula (HP:0100590)2.12042518
99Nasal polyposis (HP:0100582)2.11361275
100Cleft eyelid (HP:0000625)2.10823267
101Recurrent viral infections (HP:0004429)2.10269633
102Biconcave vertebral bodies (HP:0004586)2.09439987
103Systemic lupus erythematosus (HP:0002725)2.09433195
104Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.08377962
105Flat acetabular roof (HP:0003180)2.07912159
106Increased variability in muscle fiber diameter (HP:0003557)2.07339175
107Aplasia/Hypoplasia of the spleen (HP:0010451)2.06563849
108Hypertriglyceridemia (HP:0002155)2.05323080
109Tracheoesophageal fistula (HP:0002575)2.05207367
110Purpura (HP:0000979)2.01619789
111Interstitial pulmonary disease (HP:0006530)1.99362335
112Abnormality of complement system (HP:0005339)1.98879455
113Seborrheic dermatitis (HP:0001051)1.98666078
114Long palpebral fissure (HP:0000637)1.98464290
115Recurrent fungal infections (HP:0002841)1.97610365
116Abnormality of the Achilles tendon (HP:0005109)1.97242213
117Intestinal fistula (HP:0100819)1.97071231
118Upper limb muscle weakness (HP:0003484)1.96741137
119Abnormality of abdominal situs (HP:0011620)1.94514268
120Abdominal situs inversus (HP:0003363)1.94514268
121Ectopic kidney (HP:0000086)1.93283321
122Gastrointestinal dysmotility (HP:0002579)1.92689610
123Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.92523915
124Myositis (HP:0100614)1.92091823
125Oral leukoplakia (HP:0002745)1.91822399
126Abnormality of the thoracic spine (HP:0100711)1.90700441
127Abnormality of the duodenum (HP:0002246)1.90377618
128Aplastic anemia (HP:0001915)1.89189811
129Myopathic facies (HP:0002058)1.89168086
130Acute lymphatic leukemia (HP:0006721)1.88452751
131Abnormal lung lobation (HP:0002101)1.87176827
132Panhypogammaglobulinemia (HP:0003139)1.86763931
133Abnormality of skeletal muscle fiber size (HP:0012084)1.85203950
134Increased serum ferritin (HP:0003281)1.84283522
135Progressive muscle weakness (HP:0003323)1.83847397
136Mitral regurgitation (HP:0001653)1.83492737
137Distal lower limb muscle weakness (HP:0009053)1.83490879
138Basal cell carcinoma (HP:0002671)1.83369894
139Tongue fasciculations (HP:0001308)1.82666414
140Atrophy/Degeneration involving motor neurons (HP:0007373)1.82587888
141Short thumb (HP:0009778)1.81716439
142Metaphyseal cupping (HP:0003021)1.81715194
143Aplasia/hypoplasia of the humerus (HP:0006507)1.80862015
1443-Methylglutaconic aciduria (HP:0003535)1.79285721
145Supernumerary bones of the axial skeleton (HP:0009144)1.78884025
14611 pairs of ribs (HP:0000878)1.78234187
147Cervical subluxation (HP:0003308)1.78087815
148Secondary amenorrhea (HP:0000869)1.77134660
149Dislocated radial head (HP:0003083)1.77072665
150Dysostosis multiplex (HP:0000943)1.75671220
151Microvesicular hepatic steatosis (HP:0001414)1.75416890
152Easy fatigability (HP:0003388)1.75017636
153Abnormal sex determination (HP:0012244)1.74772279
154Sex reversal (HP:0012245)1.74772279
155Recurrent skin infections (HP:0001581)1.74568086
156Spontaneous hematomas (HP:0007420)1.73150373
157Aneurysm (HP:0002617)1.73067092
158Fragile skin (HP:0001030)1.72894939
159Increased cerebral lipofuscin (HP:0011813)1.72894516
160Type I transferrin isoform profile (HP:0003642)1.71479602
161Absent hand (HP:0004050)1.70085095
162Increased nuchal translucency (HP:0010880)1.70066343
163Abnormality of the salivary glands (HP:0010286)1.69968002
164Nephroblastoma (Wilms tumor) (HP:0002667)1.69361452
165Distal upper limb amyotrophy (HP:0007149)1.69350408
166Upper limb amyotrophy (HP:0009129)1.69350408
167Abnormal delayed hypersensitivity skin test (HP:0002963)1.68734083
168Lymphoma (HP:0002665)1.68388885
169Abnormality of the peritoneum (HP:0002585)1.68064176
170Impulsivity (HP:0100710)1.67041936
171Spinal cord lesions (HP:0100561)1.66982673
172Syringomyelia (HP:0003396)1.66982673
173Abnormality of DNA repair (HP:0003254)1.66930733
174Abnormality of the distal phalanx of the thumb (HP:0009617)1.66866773
175Aplasia/Hypoplasia of the earlobes (HP:0009906)1.66745470
176Squamous cell carcinoma (HP:0002860)1.66653116
177Clubbing of toes (HP:0100760)1.66562152
178Hypercortisolism (HP:0001578)1.65573589
179Atelectasis (HP:0100750)1.65128750
180Rhabdomyosarcoma (HP:0002859)1.64992076
181Sloping forehead (HP:0000340)1.64980515
182Neoplasm of the pancreas (HP:0002894)1.64835790
183J-shaped sella turcica (HP:0002680)1.64430744
184Hyperparathyroidism (HP:0000843)1.64111954
185Viral hepatitis (HP:0006562)1.63868702
186Tetralogy of Fallot (HP:0001636)1.63199949
187Verrucae (HP:0200043)1.63172866
188Papilloma (HP:0012740)1.63172866
189Growth hormone excess (HP:0000845)1.62704254
190Abnormal trabecular bone morphology (HP:0100671)1.62461712
191Exertional dyspnea (HP:0002875)1.61944384
192Thoracic kyphosis (HP:0002942)1.61901310
193Abnormality of the radial head (HP:0003995)1.61521427
194Abnormality of the carotid arteries (HP:0005344)1.61267771
195Alacrima (HP:0000522)1.61030487
196Premature skin wrinkling (HP:0100678)1.60019966
197Premature rupture of membranes (HP:0001788)1.59816213
198Polycythemia (HP:0001901)1.59422348
199Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.59399066
200Personality changes (HP:0000751)1.58622931

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB16.48684259
2TRIB34.94675579
3ERN14.04292078
4SMG13.58393909
5PRPF4B3.31379396
6WEE13.15292359
7CDC72.91483678
8TLK12.86949300
9TESK22.80355657
10STK162.49227999
11SRPK12.46149775
12SIK12.37628564
13CDK122.35145206
14BLK2.22900335
15CDK72.11464941
16TTK2.07254148
17MAP3K102.06632617
18EIF2AK12.06071182
19FGFR41.85460735
20EPHA21.84996298
21MKNK11.84075055
22MAP2K31.83513601
23PLK11.74714097
24RIPK41.72616672
25NEK21.70500444
26NME21.69998573
27PIM21.69927768
28MKNK21.67335055
29DYRK31.64000270
30PLK41.63882518
31RPS6KB21.59373364
32TYK21.56124765
33CDC42BPA1.54521926
34TSSK61.52710187
35VRK11.52464263
36MAP4K11.52263647
37PKN21.49471733
38RIPK11.47731196
39PNCK1.45896718
40MAP3K131.45562986
41ICK1.44610209
42ATR1.41624202
43AURKA1.41362422
44CHEK21.41129741
45MAP3K111.35444965
46TTN1.32299132
47IRAK31.25151179
48CDK41.24620862
49PTK61.22911908
50SIK21.20755227
51TBK11.16326301
52AURKB1.14873244
53MARK21.14788901
54CHEK11.12201007
55TAOK21.10656425
56EIF2AK31.08256067
57EPHB11.08220677
58PRKD21.07280220
59STK101.06209409
60TAOK11.05820142
61PIM11.03980545
62MAP3K31.03789266
63PAK41.01049360
64PDPK11.00452600
65MAPK111.00193792
66MAP3K11.00078235
67IRAK40.97967920
68ALK0.96204175
69LRRK20.95309960
70GRK60.94941070
71PAK10.94307699
72CLK10.93580277
73MAP3K80.91768339
74MAP2K20.90926705
75JAK30.89560829
76CDK80.88948671
77BRD40.88878314
78FES0.86455720
79KSR20.86437269
80KDR0.83245368
81* CDK20.82326153
82PRKCI0.81739760
83UHMK10.81099656
84PDGFRA0.80155116
85BRAF0.78073456
86MAPK120.77874214
87MAP3K140.77816690
88EIF2AK20.77760092
89RPS6KA20.76852850
90HIPK20.76253246
91EEF2K0.74589905
92TXK0.74296427
93YES10.73743212
94DYRK20.73642191
95SIK30.73452159
96MST1R0.72965089
97PRKD30.72883759
98CSNK2A20.72525427
99AKT30.72325602
100PASK0.71921459
101ATM0.71332474
102STK40.70446800
103CAMKK10.69009063
104PDK10.68420305
105ARAF0.68170665
106CDK190.67403903
107RPS6KA40.64853657
108MAP3K70.64839188
109IRAK20.63411720
110TESK10.62977519
111ZAK0.62489339
112ZAP700.61859759
113CSNK2A10.61206181
114HCK0.61022534
115BMX0.60395680
116BTK0.57978399
117RPS6KA50.57784913
118PLK30.56575372
119IKBKB0.53901153
120DYRK1B0.53736649
121CDK10.52996494
122ADRBK20.52533606
123NME10.51985538
124TNK20.51754590
125RET0.50135855
126IKBKE0.49459363
127ILK0.47163123
128LIMK10.47041322
129MAPKAPK30.45609535
130PRKG20.45000735
131FGFR30.44949335
132MAPKAPK20.44887199
133CSF1R0.43003299
134JAK10.42991443
135LYN0.42118845
136AKT20.39432770
137BRSK20.39307677
138CSK0.38866942
139MAP3K60.38454995
140CDK60.38225370
141CSNK1E0.37745303
142MATK0.37439932
143TYRO30.36810823
144DAPK10.36588148
145LCK0.36250413
146SCYL20.34551267
147GRK10.34441044
148CDK90.34258751
149ITK0.34196025
150MAPK150.33917062
151RPS6KA10.33708730
152SYK0.33636628
153RPS6KL10.33553518
154RPS6KC10.33553518
155MELK0.32489827
156IRAK10.32036707
157JAK20.31568206
158MAPK40.30904391
159MAPK70.30769768
160MTOR0.28410710
161RPS6KA60.28131073
162FGR0.27321274

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.23143612
2Ribosome_Homo sapiens_hsa030103.78425330
3Mismatch repair_Homo sapiens_hsa034303.76108966
4Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.40649315
5Spliceosome_Homo sapiens_hsa030403.24524014
6RNA polymerase_Homo sapiens_hsa030203.02395079
7Base excision repair_Homo sapiens_hsa034103.02187605
8Proteasome_Homo sapiens_hsa030502.95978553
9Homologous recombination_Homo sapiens_hsa034402.71713294
10RNA transport_Homo sapiens_hsa030132.70566236
11Nucleotide excision repair_Homo sapiens_hsa034202.50613966
12Fanconi anemia pathway_Homo sapiens_hsa034602.42394236
13Cell cycle_Homo sapiens_hsa041102.12480817
14Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.09031383
15Pyrimidine metabolism_Homo sapiens_hsa002402.06467905
16Non-small cell lung cancer_Homo sapiens_hsa052232.02089287
17Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.94988524
18mRNA surveillance pathway_Homo sapiens_hsa030151.84487114
19One carbon pool by folate_Homo sapiens_hsa006701.84262978
20Basal transcription factors_Homo sapiens_hsa030221.81514903
21VEGF signaling pathway_Homo sapiens_hsa043701.72776238
22Non-homologous end-joining_Homo sapiens_hsa034501.70298568
23Osteoclast differentiation_Homo sapiens_hsa043801.64776890
24Pancreatic cancer_Homo sapiens_hsa052121.63136866
25RNA degradation_Homo sapiens_hsa030181.62182434
26p53 signaling pathway_Homo sapiens_hsa041151.41042070
27Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.39430750
28Staphylococcus aureus infection_Homo sapiens_hsa051501.36273172
29Prion diseases_Homo sapiens_hsa050201.30483484
30Toll-like receptor signaling pathway_Homo sapiens_hsa046201.27245030
31Central carbon metabolism in cancer_Homo sapiens_hsa052301.24147927
32Toxoplasmosis_Homo sapiens_hsa051451.22271815
33mTOR signaling pathway_Homo sapiens_hsa041501.20710736
34Epstein-Barr virus infection_Homo sapiens_hsa051691.19212906
35Primary immunodeficiency_Homo sapiens_hsa053401.18663603
36Neurotrophin signaling pathway_Homo sapiens_hsa047221.15387425
37Viral myocarditis_Homo sapiens_hsa054161.12747146
38Endometrial cancer_Homo sapiens_hsa052131.09178693
39Hepatitis C_Homo sapiens_hsa051601.09076549
40AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.07606041
41Renal cell carcinoma_Homo sapiens_hsa052111.07077685
42Tuberculosis_Homo sapiens_hsa051521.05879401
43Purine metabolism_Homo sapiens_hsa002301.05648888
44Glycosaminoglycan degradation_Homo sapiens_hsa005311.04416314
45Galactose metabolism_Homo sapiens_hsa000521.04306083
46Leukocyte transendothelial migration_Homo sapiens_hsa046701.01832938
47Insulin signaling pathway_Homo sapiens_hsa049100.96388128
48Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.95583143
49Adipocytokine signaling pathway_Homo sapiens_hsa049200.95146763
50Notch signaling pathway_Homo sapiens_hsa043300.94569226
51Glioma_Homo sapiens_hsa052140.94213849
52Choline metabolism in cancer_Homo sapiens_hsa052310.93829113
53Longevity regulating pathway - mammal_Homo sapiens_hsa042110.91154115
54Herpes simplex infection_Homo sapiens_hsa051680.89927131
55Thyroid hormone signaling pathway_Homo sapiens_hsa049190.89593744
56Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.88350651
57TNF signaling pathway_Homo sapiens_hsa046680.87681513
58Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.87640360
59Phospholipase D signaling pathway_Homo sapiens_hsa040720.86482898
60Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.86082759
61Viral carcinogenesis_Homo sapiens_hsa052030.84073432
62Basal cell carcinoma_Homo sapiens_hsa052170.83289219
63Endocytosis_Homo sapiens_hsa041440.81963567
64GnRH signaling pathway_Homo sapiens_hsa049120.81682879
65ErbB signaling pathway_Homo sapiens_hsa040120.81116711
66HTLV-I infection_Homo sapiens_hsa051660.81108389
67Hedgehog signaling pathway_Homo sapiens_hsa043400.79959590
68Huntingtons disease_Homo sapiens_hsa050160.79950179
69Phosphatidylinositol signaling system_Homo sapiens_hsa040700.79676041
70Chemokine signaling pathway_Homo sapiens_hsa040620.78267033
71Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.76791243
72Phenylalanine metabolism_Homo sapiens_hsa003600.76310546
73Insulin resistance_Homo sapiens_hsa049310.75979184
74AMPK signaling pathway_Homo sapiens_hsa041520.74960456
75Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.73802406
76Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.73568844
77Biosynthesis of amino acids_Homo sapiens_hsa012300.73225146
78Antigen processing and presentation_Homo sapiens_hsa046120.72428511
79Systemic lupus erythematosus_Homo sapiens_hsa053220.71920234
80Transcriptional misregulation in cancer_Homo sapiens_hsa052020.71299679
81Oocyte meiosis_Homo sapiens_hsa041140.71234489
82Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.70770557
83Prolactin signaling pathway_Homo sapiens_hsa049170.69303114
84Inositol phosphate metabolism_Homo sapiens_hsa005620.67907632
85Sulfur relay system_Homo sapiens_hsa041220.66878874
86MicroRNAs in cancer_Homo sapiens_hsa052060.66625799
87Shigellosis_Homo sapiens_hsa051310.66344118
88Amoebiasis_Homo sapiens_hsa051460.65501430
89NF-kappa B signaling pathway_Homo sapiens_hsa040640.65320718
90Sphingolipid signaling pathway_Homo sapiens_hsa040710.64094616
91Carbohydrate digestion and absorption_Homo sapiens_hsa049730.63499169
92Lysosome_Homo sapiens_hsa041420.63057378
93Pertussis_Homo sapiens_hsa051330.63056923
94Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.62424030
95HIF-1 signaling pathway_Homo sapiens_hsa040660.62246344
96Salmonella infection_Homo sapiens_hsa051320.61197290
97Measles_Homo sapiens_hsa051620.61005498
98Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.60004630
99Malaria_Homo sapiens_hsa051440.59834402
100Apoptosis_Homo sapiens_hsa042100.59759184
101Protein export_Homo sapiens_hsa030600.57517730
102Oxidative phosphorylation_Homo sapiens_hsa001900.57463243
103Bladder cancer_Homo sapiens_hsa052190.56145122
104Estrogen signaling pathway_Homo sapiens_hsa049150.55589556
105Focal adhesion_Homo sapiens_hsa045100.55504172
106Acute myeloid leukemia_Homo sapiens_hsa052210.53919240
107Parkinsons disease_Homo sapiens_hsa050120.52369126
108Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.51372440
109Lysine degradation_Homo sapiens_hsa003100.51227036
110Platelet activation_Homo sapiens_hsa046110.50824757
111Colorectal cancer_Homo sapiens_hsa052100.50233398
112Wnt signaling pathway_Homo sapiens_hsa043100.49628459
113Hematopoietic cell lineage_Homo sapiens_hsa046400.49439430
114Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.48393632
115Asthma_Homo sapiens_hsa053100.47196567
116Hippo signaling pathway_Homo sapiens_hsa043900.46819627
117Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.45428207
118Intestinal immune network for IgA production_Homo sapiens_hsa046720.45038508
119B cell receptor signaling pathway_Homo sapiens_hsa046620.44196516
120Allograft rejection_Homo sapiens_hsa053300.43824269
121Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.43550237
122Graft-versus-host disease_Homo sapiens_hsa053320.43491487
123Other glycan degradation_Homo sapiens_hsa005110.41785728
124T cell receptor signaling pathway_Homo sapiens_hsa046600.41477162
125Pathways in cancer_Homo sapiens_hsa052000.41192623
126Hepatitis B_Homo sapiens_hsa051610.40597036
127Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.40567965
128Arachidonic acid metabolism_Homo sapiens_hsa005900.39002837
129Small cell lung cancer_Homo sapiens_hsa052220.38187759
130Legionellosis_Homo sapiens_hsa051340.38173515
131RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.37640920
132Alcoholism_Homo sapiens_hsa050340.35566786
133Autoimmune thyroid disease_Homo sapiens_hsa053200.34887026
134Chronic myeloid leukemia_Homo sapiens_hsa052200.34797245
135TGF-beta signaling pathway_Homo sapiens_hsa043500.34538195
136Vitamin B6 metabolism_Homo sapiens_hsa007500.34011064
137Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.33636264
138NOD-like receptor signaling pathway_Homo sapiens_hsa046210.32052567
139Thyroid cancer_Homo sapiens_hsa052160.30012926
140Pentose phosphate pathway_Homo sapiens_hsa000300.28944484
141Regulation of actin cytoskeleton_Homo sapiens_hsa048100.28218852
142Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.28091170
143Leishmaniasis_Homo sapiens_hsa051400.27922175
144Cyanoamino acid metabolism_Homo sapiens_hsa004600.25104175
145Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.24701564
146Jak-STAT signaling pathway_Homo sapiens_hsa046300.22949193
147Alzheimers disease_Homo sapiens_hsa050100.22676715
148Influenza A_Homo sapiens_hsa051640.21527249
149Folate biosynthesis_Homo sapiens_hsa007900.20687323
150Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.20667119
151Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.20202613
152Prostate cancer_Homo sapiens_hsa052150.19423705
153Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.19187973
154N-Glycan biosynthesis_Homo sapiens_hsa005100.19109367
155Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.18619691
156Fructose and mannose metabolism_Homo sapiens_hsa000510.18435710
157Phototransduction_Homo sapiens_hsa047440.17985767
158Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.17968749

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