INPP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes the enzyme inositol polyphosphate-1-phosphatase, one of the enzymes involved in phosphatidylinositol signaling pathways. This enzyme removes the phosphate group at position 1 of the inositol ring from the polyphosphates inositol 1,4-bisphosphate and inositol 1,3,4-trisphophosphate. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of synaptic transmission, GABAergic (GO:0032229)4.40320143
2ionotropic glutamate receptor signaling pathway (GO:0035235)4.08282564
3vocalization behavior (GO:0071625)4.01789482
4neuron cell-cell adhesion (GO:0007158)3.99697213
5glutamate receptor signaling pathway (GO:0007215)3.88912789
6positive regulation of inositol phosphate biosynthetic process (GO:0060732)3.74816088
7regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.68244295
8gamma-aminobutyric acid signaling pathway (GO:0007214)3.58055586
9presynaptic membrane assembly (GO:0097105)3.56312050
10postsynaptic membrane organization (GO:0001941)3.48269244
11G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.45517362
12positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.44000095
13synaptic transmission, glutamatergic (GO:0035249)3.43184110
14regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.42719083
15neuronal action potential propagation (GO:0019227)3.39747072
16barbed-end actin filament capping (GO:0051016)3.37863125
17cellular potassium ion homeostasis (GO:0030007)3.28459672
18neuron-neuron synaptic transmission (GO:0007270)3.26444372
19protein localization to endosome (GO:0036010)3.26179821
20regulation of inositol phosphate biosynthetic process (GO:0010919)3.23508043
21protein localization to synapse (GO:0035418)3.22854963
22regulation of glutamate receptor signaling pathway (GO:1900449)3.21784655
23presynaptic membrane organization (GO:0097090)3.17461818
24sodium ion export (GO:0071436)3.13857403
25transmission of nerve impulse (GO:0019226)3.09712818
26angiotensin maturation (GO:0002003)3.07066672
27righting reflex (GO:0060013)2.91815366
28skin morphogenesis (GO:0043589)2.88430204
29cellular response to interleukin-15 (GO:0071350)2.88180544
30regulation of short-term neuronal synaptic plasticity (GO:0048172)2.85158920
31neuron remodeling (GO:0016322)2.84274370
32synaptic vesicle exocytosis (GO:0016079)2.78775082
33positive regulation of synapse assembly (GO:0051965)2.76258931
34regulation of synaptic vesicle exocytosis (GO:2000300)2.72534118
35regulation of excitatory postsynaptic membrane potential (GO:0060079)2.71292712
36startle response (GO:0001964)2.70860646
37macroautophagy (GO:0016236)2.70488380
38cerebellar Purkinje cell differentiation (GO:0021702)2.70400497
39neurotransmitter-gated ion channel clustering (GO:0072578)2.70110619
40desmosome organization (GO:0002934)2.70041017
41negative regulation of cell killing (GO:0031342)2.68716840
42negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.68716840
43myelin maintenance (GO:0043217)2.65003329
44glycosphingolipid catabolic process (GO:0046479)2.62852052
45long-term memory (GO:0007616)2.62668529
46regulation of synaptic transmission, glutamatergic (GO:0051966)2.62661508
47regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.60401951
48regulation of synaptic transmission, GABAergic (GO:0032228)2.60007527
49response to pheromone (GO:0019236)2.59006996
50regulation of postsynaptic membrane potential (GO:0060078)2.58340344
51activated T cell proliferation (GO:0050798)2.57970924
52gamma-aminobutyric acid transport (GO:0015812)2.57558166
53virion attachment to host cell (GO:0019062)2.57132085
54adhesion of symbiont to host cell (GO:0044650)2.57132085
55positive regulation of extracellular matrix organization (GO:1903055)2.57019267
56positive regulation of protein dephosphorylation (GO:0035307)2.55858110
57negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.55262188
58glycolipid catabolic process (GO:0019377)2.54045556
59response to histamine (GO:0034776)2.53315647
60positive regulation of synaptic transmission, GABAergic (GO:0032230)2.51798353
61regulation of synapse assembly (GO:0051963)2.51243841
62neuron recognition (GO:0008038)2.50786099
63regulation of vesicle fusion (GO:0031338)2.50329468
64regulation of isotype switching to IgG isotypes (GO:0048302)2.48423061
65adhesion of symbiont to host (GO:0044406)2.46639881
66positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.46423630
67locomotory exploration behavior (GO:0035641)2.46280591
68mating behavior (GO:0007617)2.44977539
69synaptic vesicle docking involved in exocytosis (GO:0016081)2.42723347
70positive regulation of triglyceride lipase activity (GO:0061365)2.42404023
71positive regulation of lipoprotein lipase activity (GO:0051006)2.42404023
72membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.42218852
73sexual reproduction (GO:0019953)2.42216173
74neurotransmitter secretion (GO:0007269)2.41541501
75behavioral response to pain (GO:0048266)2.41132303
76membrane depolarization (GO:0051899)2.40642365
77glutamate secretion (GO:0014047)2.40125589
78cell volume homeostasis (GO:0006884)2.39994642
79serotonin receptor signaling pathway (GO:0007210)2.39325163
80positive regulation of CREB transcription factor activity (GO:0032793)2.39302408
81response to interleukin-15 (GO:0070672)2.38891504
82cranial nerve structural organization (GO:0021604)2.38842996
83positive regulation of membrane potential (GO:0045838)2.38254469
84positive regulation of uterine smooth muscle contraction (GO:0070474)2.37924945
85stress fiber assembly (GO:0043149)2.37527308
86erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.37115104
87L-phenylalanine metabolic process (GO:0006558)2.37115104
88regulation of long-term neuronal synaptic plasticity (GO:0048169)2.37027093
89response to epinephrine (GO:0071871)2.36662505
90cerebral cortex radially oriented cell migration (GO:0021799)2.36121104
91synapse assembly (GO:0007416)2.35378440
92membrane depolarization during action potential (GO:0086010)2.35091525
93protein retention in ER lumen (GO:0006621)2.34980550
94maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.34246743
95interferon-gamma production (GO:0032609)2.34032330
96cell adhesion mediated by integrin (GO:0033627)2.33955527
97cellular sodium ion homeostasis (GO:0006883)2.33593813
98regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.33382265
99regulation of pigment cell differentiation (GO:0050932)2.30782635
100cerebellar granule cell differentiation (GO:0021707)2.30117677
101regulation of early endosome to late endosome transport (GO:2000641)2.29952803
102calcium ion import (GO:0070509)2.29921750
103limb bud formation (GO:0060174)2.29702801
104negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.29375379
105cellular response to pH (GO:0071467)2.29223863
106positive regulation of action potential (GO:0045760)2.29029528
107neurotransmitter transport (GO:0006836)2.28840816
108protein localization to cilium (GO:0061512)2.28556207
109axon ensheathment in central nervous system (GO:0032291)2.28539635
110central nervous system myelination (GO:0022010)2.28539635
111regulation of synaptic vesicle transport (GO:1902803)2.28120588
112regulation of axon regeneration (GO:0048679)2.27190036
113regulation of neuron projection regeneration (GO:0070570)2.27190036
114inner ear receptor stereocilium organization (GO:0060122)2.27016767
115hypotonic response (GO:0006971)2.26863391
116regulation of neurotransmitter secretion (GO:0046928)2.26859877
117cofactor catabolic process (GO:0051187)2.26826576
118negative regulation of neurotransmitter transport (GO:0051589)2.26372331
119long-term synaptic potentiation (GO:0060291)2.26368049
120regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.25407590
121definitive hemopoiesis (GO:0060216)2.25151069
122positive regulation of pseudopodium assembly (GO:0031274)2.25137871
123positive regulation of neurotransmitter secretion (GO:0001956)2.25136082
124regulation of platelet aggregation (GO:0090330)2.25074415
125auditory behavior (GO:0031223)2.24101766
126regulation of B cell receptor signaling pathway (GO:0050855)2.23592576
127detection of calcium ion (GO:0005513)2.22516326
128retina layer formation (GO:0010842)2.22269669
129peptide hormone processing (GO:0016486)2.21692958
130regulation of plasminogen activation (GO:0010755)2.21093868
131regulation of voltage-gated calcium channel activity (GO:1901385)2.20852629
132fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.20831535
133regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.20226622
134fibrinolysis (GO:0042730)2.20159991
135cell differentiation in hindbrain (GO:0021533)2.19554909
136potassium ion homeostasis (GO:0055075)2.19505139
137mechanosensory behavior (GO:0007638)2.19427430
138reflex (GO:0060004)2.18668351
139cellular response to epinephrine stimulus (GO:0071872)2.18470341
140cyclooxygenase pathway (GO:0019371)2.17741914
141opioid receptor signaling pathway (GO:0038003)2.17475679
142regulation of cholesterol homeostasis (GO:2000188)2.17174425
143learning (GO:0007612)2.16934727
144mesenchymal cell differentiation involved in kidney development (GO:0072161)2.16916601
145regulation of transforming growth factor beta1 production (GO:0032908)2.16746124
146response to thyroid hormone (GO:0097066)2.16349871
147regulation of protein dephosphorylation (GO:0035304)2.16135498
148endocytic recycling (GO:0032456)2.15356239
149endoplasmic reticulum calcium ion homeostasis (GO:0032469)2.14884724
150peptide catabolic process (GO:0043171)2.14686427
151negative regulation of fibrinolysis (GO:0051918)2.13562255
152regulation of pseudopodium assembly (GO:0031272)2.11797821
153regulation of extracellular matrix disassembly (GO:0010715)2.11751464
154L-phenylalanine catabolic process (GO:0006559)2.11530743
155erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.11530743
156synaptic vesicle maturation (GO:0016188)2.10149817
157regulation of macrophage chemotaxis (GO:0010758)2.07881262
158actin filament depolymerization (GO:0030042)2.07397419
159type B pancreatic cell proliferation (GO:0044342)2.06048439
160regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)2.05518221
161regulation of vitamin metabolic process (GO:0030656)2.05373274
162complement activation, classical pathway (GO:0006958)2.05271474
163mature B cell differentiation involved in immune response (GO:0002313)2.04537011
164negative regulation of hydrogen peroxide-induced cell death (GO:1903206)2.03829811
165Golgi transport vesicle coating (GO:0048200)2.03264322
166COPI coating of Golgi vesicle (GO:0048205)2.03264322
167response to acidic pH (GO:0010447)2.01655422
168ceramide catabolic process (GO:0046514)2.01245216
169hyaluronan catabolic process (GO:0030214)2.00162917
170regulation of extracellular matrix organization (GO:1903053)1.97726240
171oligosaccharide catabolic process (GO:0009313)1.97657059
172proline transport (GO:0015824)1.97175700
173actin filament capping (GO:0051693)1.95882911
174astrocyte differentiation (GO:0048708)1.94771898
175positive regulation of cellular amine metabolic process (GO:0033240)1.94707333
176response to lead ion (GO:0010288)1.93228267
177hemidesmosome assembly (GO:0031581)1.93053315
178positive regulation of receptor recycling (GO:0001921)1.92780829
179negative regulation of response to reactive oxygen species (GO:1901032)1.92329191
180regulation of complement activation (GO:0030449)1.92207531
181receptor recycling (GO:0001881)1.90571729
182response to gravity (GO:0009629)1.89497601
183negative regulation of coagulation (GO:0050819)1.88928695
184complement activation (GO:0006956)1.88559290
185regulation of protein activation cascade (GO:2000257)1.88225985
186peptidyl-glutamic acid carboxylation (GO:0017187)1.88098696
187protein carboxylation (GO:0018214)1.88098696
188regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)1.87461475
189response to pH (GO:0009268)1.86385447
190negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)1.85989243
191cellular copper ion homeostasis (GO:0006878)1.85169059
192negative regulation of hemostasis (GO:1900047)1.84622757
193negative regulation of blood coagulation (GO:0030195)1.84622757
194antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)1.84427647
195membrane raft organization (GO:0031579)1.84217881
196negative regulation of complement activation (GO:0045916)1.84076428
197serine transport (GO:0032329)1.82410929

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human4.66843667
2EZH2_22144423_ChIP-Seq_EOC_Human4.36561411
3GBX2_23144817_ChIP-Seq_PC3_Human3.90641495
4JARID2_20064375_ChIP-Seq_MESCs_Mouse2.73522332
5TAF15_26573619_Chip-Seq_HEK293_Human2.69465257
6SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.67681709
7TRIM28_21343339_ChIP-Seq_HEK293_Human2.54066791
8SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.50643979
9ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.41119416
10RARG_19884340_ChIP-ChIP_MEFs_Mouse2.40947028
11ZFP57_27257070_Chip-Seq_ESCs_Mouse2.35152731
12EED_16625203_ChIP-ChIP_MESCs_Mouse2.34365263
13SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.33309622
14SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.29872126
15EZH2_27304074_Chip-Seq_ESCs_Mouse2.29137115
16SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.26133493
17RNF2_18974828_ChIP-Seq_MESCs_Mouse2.25169156
18EZH2_18974828_ChIP-Seq_MESCs_Mouse2.25169156
19AR_21572438_ChIP-Seq_LNCaP_Human2.20783061
20SMAD_19615063_ChIP-ChIP_OVARY_Human2.19294562
21THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.18572132
22JARID2_20075857_ChIP-Seq_MESCs_Mouse2.17357079
23TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.02611141
24GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.00751602
25PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.97493793
26MTF2_20144788_ChIP-Seq_MESCs_Mouse1.95245021
27PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.94971920
28P300_19829295_ChIP-Seq_ESCs_Human1.91792468
29* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.91574952
30IRF8_22096565_ChIP-ChIP_GC-B_Human1.91436382
31GATA2_21666600_ChIP-Seq_HMVEC_Human1.90111608
32* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.87519180
33BMI1_23680149_ChIP-Seq_NPCS_Mouse1.87401640
34FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.86976923
35TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.85623976
36RXR_22158963_ChIP-Seq_LIVER_Mouse1.84676765
37PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.82204379
38LXR_22292898_ChIP-Seq_THP-1_Human1.81529006
39RNF2_27304074_Chip-Seq_ESCs_Mouse1.80037062
40TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.78492735
41SUZ12_27294783_Chip-Seq_ESCs_Mouse1.78444544
42EZH2_27294783_Chip-Seq_ESCs_Mouse1.77730467
43FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.77711792
44GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.73134264
45CBX2_27304074_Chip-Seq_ESCs_Mouse1.71026655
46CTBP1_25329375_ChIP-Seq_LNCAP_Human1.70587894
47RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.70199463
48NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.69815258
49SMAD4_21799915_ChIP-Seq_A2780_Human1.69391931
50CTBP2_25329375_ChIP-Seq_LNCAP_Human1.68446834
51* FLI1_27457419_Chip-Seq_LIVER_Mouse1.67556066
52IKZF1_21737484_ChIP-ChIP_HCT116_Human1.67411762
53* PCGF2_27294783_Chip-Seq_ESCs_Mouse1.67267459
54REST_21632747_ChIP-Seq_MESCs_Mouse1.62718694
55PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.62259146
56SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.61699339
57DROSHA_22980978_ChIP-Seq_HELA_Human1.61490147
58CDX2_19796622_ChIP-Seq_MESCs_Mouse1.57791726
59TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.54621811
60VDR_22108803_ChIP-Seq_LS180_Human1.54428094
61P63_26484246_Chip-Seq_KERATINOCYTES_Human1.54035267
62ESR2_21235772_ChIP-Seq_MCF-7_Human1.52279667
63PIAS1_25552417_ChIP-Seq_VCAP_Human1.52114889
64IGF1R_20145208_ChIP-Seq_DFB_Human1.51241234
65Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.49426611
66CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.48359081
67* SUZ12_27294783_Chip-Seq_NPCs_Mouse1.46506075
68IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.43995958
69RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.43322095
70SMAD3_21741376_ChIP-Seq_EPCs_Human1.42490441
71* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.41898574
72* NANOG_18555785_Chip-Seq_ESCs_Mouse1.41381346
73MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.41124701
74SOX2_20726797_ChIP-Seq_SW620_Human1.40853916
75RNF2_27304074_Chip-Seq_NSC_Mouse1.39506400
76FUS_26573619_Chip-Seq_HEK293_Human1.38494803
77UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.38116076
78ELK3_25401928_ChIP-Seq_HUVEC_Human1.37844614
79ER_23166858_ChIP-Seq_MCF-7_Human1.37680177
80TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.37041810
81* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.35912585
82STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.34825220
83JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.34416086
84TOP2B_26459242_ChIP-Seq_MCF-7_Human1.34153053
85SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.32675171
86NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.32348152
87PPARA_22158963_ChIP-Seq_LIVER_Mouse1.32206237
88* E2F1_18555785_Chip-Seq_ESCs_Mouse1.32176750
89OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.32164344
90JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.32077433
91LXR_22158963_ChIP-Seq_LIVER_Mouse1.31730301
92AR_25329375_ChIP-Seq_VCAP_Human1.31106969
93* NFE2_27457419_Chip-Seq_LIVER_Mouse1.29679960
94* P53_22387025_ChIP-Seq_ESCs_Mouse1.27953600
95VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.27143673
96IRF8_21731497_ChIP-ChIP_J774_Mouse1.25138307
97DNAJC2_21179169_ChIP-ChIP_NT2_Human1.25040513
98* EZH2_27294783_Chip-Seq_NPCs_Mouse1.24471081
99CJUN_26792858_Chip-Seq_BT549_Human1.23592341
100NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.23052295
101CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.22572725
102CLOCK_20551151_ChIP-Seq_293T_Human1.22227544
103* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.21922450
104* CMYC_18555785_Chip-Seq_ESCs_Mouse1.21864452
105TP53_18474530_ChIP-ChIP_U2OS_Human1.21033396
106TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.19995735
107* SUZ12_18555785_Chip-Seq_ESCs_Mouse1.19548680
108* PCGF2_27294783_Chip-Seq_NPCs_Mouse1.19272897
109AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.18798106
110SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.17962930
111CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.17819206
112SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.17429944
113SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.17429944
114TET1_21490601_ChIP-Seq_MESCs_Mouse1.16477392
115* EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.16130014
116ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.15834208
117RACK7_27058665_Chip-Seq_MCF-7_Human1.15274587
118STAT3_23295773_ChIP-Seq_U87_Human1.14810080
119CDX2_20551321_ChIP-Seq_CACO-2_Human1.14764683
120RUNX2_22187159_ChIP-Seq_PCA_Human1.14288863
121CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.14083737
122TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.13923071
123POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.13923071
124PRDM14_20953172_ChIP-Seq_ESCs_Human1.13282674
125SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.13223903
126TCF4_23295773_ChIP-Seq_U87_Human1.13222964
127* STAT3_18555785_Chip-Seq_ESCs_Mouse1.13056562
128* P300_18555785_Chip-Seq_ESCs_Mouse1.12953587
129* NMYC_18555785_Chip-Seq_ESCs_Mouse1.12442049
130* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.11854220
131TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.10229475
132ZNF217_24962896_ChIP-Seq_MCF-7_Human1.10004283
133TP53_16413492_ChIP-PET_HCT116_Human1.09857483
134RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.09172489
135BP1_19119308_ChIP-ChIP_Hs578T_Human1.08218583
136KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.07758737
137TP53_22127205_ChIP-Seq_IMR90_Human1.07740817
138KDM2B_26808549_Chip-Seq_REH_Human1.06211838
139TBX20_22328084_ChIP-Seq_HEART_Mouse1.06084123
140TBX20_22080862_ChIP-Seq_HEART_Mouse1.06084123
141SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.06033470
142NR3C1_21868756_ChIP-Seq_MCF10A_Human1.06019798
143RUNX_20019798_ChIP-Seq_JUKART_Human1.05802017
144ARNT_22903824_ChIP-Seq_MCF-7_Human1.04927767
145PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.04761925
146NR3C1_23031785_ChIP-Seq_PC12_Mouse1.04571384
147PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.04303285
148BCAT_22108803_ChIP-Seq_LS180_Human1.03913274
149* RUNX1_27457419_Chip-Seq_LIVER_Mouse1.03893410
150RAD21_21589869_ChIP-Seq_MESCs_Mouse1.03838221
151* SOX2_18555785_Chip-Seq_ESCs_Mouse1.03684386
152PPAR_26484153_Chip-Seq_NCI-H1993_Human1.02075938
153KDM2B_26808549_Chip-Seq_SUP-B15_Human1.01705897
154UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.01141638
155SOX2_27498859_Chip-Seq_STOMACH_Mouse1.00502641
156REST_18959480_ChIP-ChIP_MESCs_Mouse1.00483952
157* OCT4_18555785_Chip-Seq_ESCs_Mouse1.00375012
158TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00169554
159NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.99151582
160* PU1_27457419_Chip-Seq_LIVER_Mouse0.98736322
161LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.96395982
162EP300_21415370_ChIP-Seq_HL-1_Mouse0.94287660
163SRY_22984422_ChIP-ChIP_TESTIS_Rat0.92813725
164ATF3_27146783_Chip-Seq_COLON_Human0.92630833
165* TP63_22573176_ChIP-Seq_HFKS_Human0.91526843
166* FOXA2_19822575_ChIP-Seq_HepG2_Human0.91241594
167IRF8_27001747_Chip-Seq_BMDM_Mouse0.90182999
168P300_27058665_Chip-Seq_ZR-75-30cells_Human0.89917674
169* SMC1_22415368_ChIP-Seq_MEFs_Mouse0.88675328
170KDM2B_26808549_Chip-Seq_K562_Human0.87222456
171KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.87031866
172GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.86943879
173PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.86820606
174NFIB_24661679_ChIP-Seq_LUNG_Mouse0.86126807
175SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.85050815
176GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.84302328
177* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.84189600
178BCOR_27268052_Chip-Seq_Bcells_Human0.83553308
179FOXO3_23340844_ChIP-Seq_DLD1_Human0.83493463
180CTCF_27219007_Chip-Seq_Bcells_Human0.82609456
181SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.82467469
182CTCF_27219007_Chip-Seq_ERYTHROID_Human0.82149697
183ESR1_21235772_ChIP-Seq_MCF-7_Human0.81985982
184ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.80867569

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern3.75355974
2MP0001188_hyperpigmentation3.24776678
3MP0004859_abnormal_synaptic_plasticity3.16640450
4MP0009840_abnormal_foam_cell3.08296448
5MP0001968_abnormal_touch/_nociception3.01787264
6MP0002735_abnormal_chemical_nociception2.86554068
7MP0002139_abnormal_hepatobiliary_system2.86134990
8MP0003329_amyloid_beta_deposits2.75196079
9MP0003635_abnormal_synaptic_transmissio2.67743975
10MP0009745_abnormal_behavioral_response2.63211601
11MP0002736_abnormal_nociception_after2.62695267
12MP0009046_muscle_twitch2.61581558
13MP0005058_abnormal_lysosome_morphology2.60133476
14MP0003075_altered_response_to2.45101206
15MP0001486_abnormal_startle_reflex2.31220299
16MP0010234_abnormal_vibrissa_follicle2.25835728
17MP0005360_urolithiasis2.25396895
18MP0002272_abnormal_nervous_system2.24978693
19MP0002064_seizures2.24579205
20MP0001501_abnormal_sleep_pattern2.19039438
21MP0006292_abnormal_olfactory_placode2.18620034
22MP0002572_abnormal_emotion/affect_behav2.09965182
23MP0000604_amyloidosis2.09103855
24MP0005365_abnormal_bile_salt2.05600954
25MP0005423_abnormal_somatic_nervous2.05399339
26MP0003950_abnormal_plasma_membrane2.04829401
27MP0003191_abnormal_cellular_cholesterol2.04700536
28MP0002102_abnormal_ear_morphology2.04544040
29MP0003787_abnormal_imprinting2.04121763
30MP0002877_abnormal_melanocyte_morpholog2.02451703
31MP0002063_abnormal_learning/memory/cond2.00688339
32MP0002067_abnormal_sensory_capabilities1.94631750
33MP0005409_darkened_coat_color1.94327278
34MP0006276_abnormal_autonomic_nervous1.92604390
35MP0005646_abnormal_pituitary_gland1.92097936
36MP0001986_abnormal_taste_sensitivity1.88321451
37MP0006082_CNS_inflammation1.83517116
38MP0005166_decreased_susceptibility_to1.80206832
39MP0005165_increased_susceptibility_to1.79741039
40MP0010368_abnormal_lymphatic_system1.78085658
41MP0001440_abnormal_grooming_behavior1.76010902
42MP0002734_abnormal_mechanical_nocicepti1.75409660
43MP0004742_abnormal_vestibular_system1.72501792
44MP0005645_abnormal_hypothalamus_physiol1.68568671
45MP0009379_abnormal_foot_pigmentation1.66481576
46MP0000013_abnormal_adipose_tissue1.65192322
47MP0004270_analgesia1.64532369
48MP0008569_lethality_at_weaning1.62587994
49MP0003303_peritoneal_inflammation1.62270170
50MP0008438_abnormal_cutaneous_collagen1.61979102
51MP0001984_abnormal_olfaction1.61871377
52MP0002184_abnormal_innervation1.58177369
53MP0004142_abnormal_muscle_tone1.55350612
54MP0003690_abnormal_glial_cell1.54343113
55MP0001970_abnormal_pain_threshold1.52425848
56MP0004134_abnormal_chest_morphology1.51862706
57MP0005551_abnormal_eye_electrophysiolog1.51811656
58MP0002557_abnormal_social/conspecific_i1.48879028
59MP0005257_abnormal_intraocular_pressure1.48590082
60MP0002733_abnormal_thermal_nociception1.46326763
61MP0003436_decreased_susceptibility_to1.45388707
62MP0005671_abnormal_response_to1.44754447
63MP0002876_abnormal_thyroid_physiology1.44082313
64MP0005023_abnormal_wound_healing1.40920560
65MP0009785_altered_susceptibility_to1.39708837
66MP0005410_abnormal_fertilization1.39682936
67MP0001502_abnormal_circadian_rhythm1.38750623
68MP0001905_abnormal_dopamine_level1.36955747
69MP0003453_abnormal_keratinocyte_physiol1.35667955
70MP0000015_abnormal_ear_pigmentation1.34632670
71MP0001533_abnormal_skeleton_physiology1.34032471
72MP0003300_gastrointestinal_ulcer1.32357455
73MP0005275_abnormal_skin_tensile1.30545091
74MP0002638_abnormal_pupillary_reflex1.29598141
75MP0003879_abnormal_hair_cell1.29489927
76MP0000678_abnormal_parathyroid_gland1.28572424
77MP0001963_abnormal_hearing_physiology1.28547538
78MP0005171_absent_coat_pigmentation1.25197924
79MP0000343_altered_response_to1.23838931
80MP0005085_abnormal_gallbladder_physiolo1.23792280
81MP0005386_behavior/neurological_phenoty1.22610927
82MP0004924_abnormal_behavior1.22610927
83MP0005174_abnormal_tail_pigmentation1.21409788
84MP0003724_increased_susceptibility_to1.19788865
85MP0002822_catalepsy1.19269986
86MP0001542_abnormal_bone_strength1.19255261
87MP0002796_impaired_skin_barrier1.16881228
88MP0003091_abnormal_cell_migration1.15100403
89MP0009780_abnormal_chondrocyte_physiolo1.14092470
90MP0003763_abnormal_thymus_physiology1.13839607
91MP0004947_skin_inflammation1.13339955
92MP0003705_abnormal_hypodermis_morpholog1.12824794
93MP0003172_abnormal_lysosome_physiology1.12061297
94MP0001666_abnormal_nutrient_absorption1.11626808
95MP0002896_abnormal_bone_mineralization1.09679698
96MP0000026_abnormal_inner_ear1.09287777
97MP0001958_emphysema1.07434083
98MP0002998_abnormal_bone_remodeling1.06030263
99MP0003045_fibrosis1.05862302
100MP0000566_synostosis1.05378052
101MP0002933_joint_inflammation1.05147541
102MP0005623_abnormal_meninges_morphology1.05048008
103MP0003136_yellow_coat_color1.04018246
104MP0002332_abnormal_exercise_endurance1.03561140
105MP0002971_abnormal_brown_adipose1.03403782
106MP0001529_abnormal_vocalization1.02630637
107MP0000003_abnormal_adipose_tissue1.02082372
108MP0002295_abnormal_pulmonary_circulatio1.01805230
109MP0003195_calcinosis1.01790919
110MP0003566_abnormal_cell_adhesion1.01483845
111MP0009250_abnormal_appendicular_skeleto1.01126561
112MP0006072_abnormal_retinal_apoptosis1.01097540
113MP0005535_abnormal_body_temperature1.00056556
114MP0004381_abnormal_hair_follicle0.99865168
115MP0004510_myositis0.98991603
116MP0010386_abnormal_urinary_bladder0.98810603
117MP0000778_abnormal_nervous_system0.98754465
118MP0005167_abnormal_blood-brain_barrier0.98161433
119MP0001664_abnormal_digestion0.97737082
120MP0002060_abnormal_skin_morphology0.97315513
121MP0000858_altered_metastatic_potential0.97030422
122MP0003183_abnormal_peptide_metabolism0.95472098
123MP0005164_abnormal_response_to0.95427000
124MP0003279_aneurysm0.94691536
125MP0003634_abnormal_glial_cell0.93979149
126MP0010329_abnormal_lipoprotein_level0.93952376
127MP0002277_abnormal_respiratory_mucosa0.92222869
128MP0003656_abnormal_erythrocyte_physiolo0.91010019
129MP0004272_abnormal_basement_membrane0.89118654
130MP0002419_abnormal_innate_immunity0.88571419
131MP0002752_abnormal_somatic_nervous0.88391482
132MP0000920_abnormal_myelination0.88208750
133MP0004145_abnormal_muscle_electrophysio0.87978894
134MP0002882_abnormal_neuron_morphology0.87694692
135MP0000631_abnormal_neuroendocrine_gland0.86317490
136MP0009764_decreased_sensitivity_to0.86035642
137MP0002066_abnormal_motor_capabilities/c0.85981025
138MP0002148_abnormal_hypersensitivity_rea0.85711078
139MP0002118_abnormal_lipid_homeostasis0.84961232
140MP0005390_skeleton_phenotype0.83815231
141MP0001835_abnormal_antigen_presentation0.83591804
142MP0005387_immune_system_phenotype0.83237688
143MP0001790_abnormal_immune_system0.83237688
144MP0005501_abnormal_skin_physiology0.82848453
145MP0005379_endocrine/exocrine_gland_phen0.81608467
146MP0005025_abnormal_response_to0.81206417
147MP0000685_abnormal_immune_system0.80938133
148MP0004885_abnormal_endolymph0.79930985
149MP0004019_abnormal_vitamin_homeostasis0.79798340
150MP0001873_stomach_inflammation0.79789215
151MP0005253_abnormal_eye_physiology0.79762477
152MP0003633_abnormal_nervous_system0.78520627
153MP0001216_abnormal_epidermal_layer0.78462740
154MP0003828_pulmonary_edema0.78152403
155MP0001765_abnormal_ion_homeostasis0.76869524
156MP0010155_abnormal_intestine_physiology0.76810882
157MP0006054_spinal_hemorrhage0.76422537
158MP0008004_abnormal_stomach_pH0.75768144
159MP0002909_abnormal_adrenal_gland0.75582309
160MP0003806_abnormal_nucleotide_metabolis0.75157399
161MP0000955_abnormal_spinal_cord0.75095989
162MP0002095_abnormal_skin_pigmentation0.73005294
163MP0009697_abnormal_copulation0.72908348
164MP0000049_abnormal_middle_ear0.71706473
165MP0008874_decreased_physiological_sensi0.71413867
166MP0003868_abnormal_feces_composition0.69602341
167MP0001485_abnormal_pinna_reflex0.68570153
168MP0000372_irregular_coat_pigmentation0.68157627
169MP0005310_abnormal_salivary_gland0.66783170
170MP0001299_abnormal_eye_distance/0.66577188
171MP0004484_altered_response_of0.66066529
172MP0002229_neurodegeneration0.65964808
173MP0002163_abnormal_gland_morphology0.65753633
174MP0005595_abnormal_vascular_smooth0.64891687
175MP0001270_distended_abdomen0.61173205
176MP0005000_abnormal_immune_tolerance0.60976161
177MP0008260_abnormal_autophagy0.58677525

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)5.63512591
2Febrile seizures (HP:0002373)4.59794315
3Epiphyseal dysplasia (HP:0002656)4.11057728
4Abnormality of glycolipid metabolism (HP:0010969)4.00611475
5Abnormality of liposaccharide metabolism (HP:0010968)4.00611475
6Abnormality of glycosphingolipid metabolism (HP:0004343)4.00611475
7Hyperventilation (HP:0002883)3.68294535
8Vitreoretinal degeneration (HP:0000655)3.64889805
9Abnormality of incisor morphology (HP:0011063)3.62226465
10Atonic seizures (HP:0010819)3.61882264
11Epileptic encephalopathy (HP:0200134)3.54918226
12Progressive cerebellar ataxia (HP:0002073)3.51249051
13Dynein arm defect of respiratory motile cilia (HP:0012255)3.39641136
14Absent/shortened dynein arms (HP:0200106)3.39641136
15Neurofibrillary tangles (HP:0002185)3.35244259
16Irregular epiphyses (HP:0010582)3.33193927
17Metaphyseal dysplasia (HP:0100255)3.31731528
18Focal seizures (HP:0007359)3.21553600
19Systemic lupus erythematosus (HP:0002725)3.16955813
20Abnormality of aromatic amino acid family metabolism (HP:0004338)3.11316737
21Abnormality of binocular vision (HP:0011514)2.92869078
22Diplopia (HP:0000651)2.92869078
23Mitral stenosis (HP:0001718)2.91856954
24Supranuclear gaze palsy (HP:0000605)2.90766467
25Vertebral compression fractures (HP:0002953)2.85325472
26Dysostosis multiplex (HP:0000943)2.72943195
27Complement deficiency (HP:0004431)2.72201864
28Myokymia (HP:0002411)2.71492828
29Vascular calcification (HP:0004934)2.70231200
30Broad-based gait (HP:0002136)2.69196414
31Axonal loss (HP:0003447)2.64630440
32Hypothermia (HP:0002045)2.62233936
33Congenital stationary night blindness (HP:0007642)2.60827729
34White forelock (HP:0002211)2.59431306
35Cardiovascular calcification (HP:0011915)2.58472756
36Gaze-evoked nystagmus (HP:0000640)2.57899801
37Amyloidosis (HP:0011034)2.57529469
38Action tremor (HP:0002345)2.56749445
39Abnormality of complement system (HP:0005339)2.56079692
40Patchy hypopigmentation of hair (HP:0011365)2.55280146
41Tubulointerstitial nephritis (HP:0001970)2.53484183
42Deep venous thrombosis (HP:0002625)2.53307276
43Growth hormone excess (HP:0000845)2.50401511
44Cerebral inclusion bodies (HP:0100314)2.49656900
45Vacuolated lymphocytes (HP:0001922)2.49380303
46Short femoral neck (HP:0100864)2.48098092
47Small epiphyses (HP:0010585)2.47033127
48Absence seizures (HP:0002121)2.43756089
49Malnutrition (HP:0004395)2.43537903
50Abnormality of glutamine family amino acid metabolism (HP:0010902)2.42811592
51Abnormality of glycosaminoglycan metabolism (HP:0004371)2.40209250
52Abnormality of mucopolysaccharide metabolism (HP:0011020)2.40209250
53Abnormality of polysaccharide metabolism (HP:0011012)2.40209250
54Mixed hearing impairment (HP:0000410)2.39993500
55Protrusio acetabuli (HP:0003179)2.39532655
56Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.38367577
57Abnormality of proline metabolism (HP:0010907)2.36732808
58Hydroxyprolinuria (HP:0003080)2.36732808
59Abnormality of the vertebral endplates (HP:0005106)2.31511512
60Urinary glycosaminoglycan excretion (HP:0003541)2.30988313
61Mucopolysacchariduria (HP:0008155)2.30988313
62Aplasia cutis congenita (HP:0001057)2.30825063
63Asymmetric septal hypertrophy (HP:0001670)2.30465603
64Abnormality of the nasal septum (HP:0000419)2.28251650
65Generalized tonic-clonic seizures (HP:0002069)2.26160271
66Abnormal ciliary motility (HP:0012262)2.25448515
67Abnormal respiratory epithelium morphology (HP:0012253)2.23814339
68Abnormal respiratory motile cilium morphology (HP:0005938)2.23814339
69Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)2.23600137
70Hypoplastic ischia (HP:0003175)2.20653080
71Diminished motivation (HP:0000745)2.19632821
72Xanthomatosis (HP:0000991)2.18584142
73Premature rupture of membranes (HP:0001788)2.17738939
74Hyperparathyroidism (HP:0000843)2.17214935
75Abnormal hair whorl (HP:0010721)2.17140837
76Mutism (HP:0002300)2.16066768
77Upper limb amyotrophy (HP:0009129)2.15654903
78Distal upper limb amyotrophy (HP:0007149)2.15654903
79Dialeptic seizures (HP:0011146)2.15191630
80Abnormality of the ischium (HP:0003174)2.14277921
81Atrophic scars (HP:0001075)2.14088176
82Apathy (HP:0000741)2.13678058
83Abnormality of the Achilles tendon (HP:0005109)2.12488074
84Genu varum (HP:0002970)2.11604472
85Distal lower limb muscle weakness (HP:0009053)2.10829704
86Absent frontal sinuses (HP:0002688)2.10773614
87Fibular hypoplasia (HP:0003038)2.10286019
88Chronic hepatic failure (HP:0100626)2.09206674
89Chronic sinusitis (HP:0011109)2.08979546
90Visual hallucinations (HP:0002367)2.07773343
91Intention tremor (HP:0002080)2.06875987
92Decreased central vision (HP:0007663)2.06225953
93Upper limb muscle weakness (HP:0003484)2.06039685
94Delusions (HP:0000746)2.05162303
95Progressive neurologic deterioration (HP:0002344)2.04822459
96Fat malabsorption (HP:0002630)2.03371974
97Spastic paraparesis (HP:0002313)2.03201144
98Retinal dysplasia (HP:0007973)2.02098602
99Agammaglobulinemia (HP:0004432)2.01557805
100Achilles tendon contracture (HP:0001771)2.01444598
101Esotropia (HP:0000565)2.00710729
102Abnormality of monocarboxylic acid metabolism (HP:0010996)2.00254852
103Fair hair (HP:0002286)1.99981872
104Cupped ribs (HP:0000887)1.98946276
105Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.98254427
106Steatorrhea (HP:0002570)1.97988254
107Nuclear cataract (HP:0100018)1.97370455
108Flat capital femoral epiphysis (HP:0003370)1.97345325
109Bradycardia (HP:0001662)1.96277482
110Acanthosis nigricans (HP:0000956)1.94653482
111Short tibia (HP:0005736)1.93585737
112Absent rod-and cone-mediated responses on ERG (HP:0007688)1.92708716
113Hand muscle atrophy (HP:0009130)1.90733839
114Glomerulonephritis (HP:0000099)1.90036810
115Loss of speech (HP:0002371)1.90026686
116Arthropathy (HP:0003040)1.89869909
117Aplasia/Hypoplasia of the tibia (HP:0005772)1.89470862
118Generalized hypopigmentation of hair (HP:0011358)1.88196757
119Chronic mucocutaneous candidiasis (HP:0002728)1.87985587
120Recurrent cutaneous fungal infections (HP:0011370)1.87985587
121Absent speech (HP:0001344)1.87653130
122Abnormality of calcium-phosphate metabolism (HP:0100530)1.87564035
123Metaphyseal irregularity (HP:0003025)1.86687870
124Abnormal delayed hypersensitivity skin test (HP:0002963)1.86334765
125Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.85908643
126Rigidity (HP:0002063)1.84909012
127Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.84671804
128Menstrual irregularities (HP:0000858)1.83254106
129Abnormality involving the epiphyses of the lower limbs (HP:0006500)1.82270393
130Abnormality of femoral epiphyses (HP:0006499)1.82270393
131Fragile skin (HP:0001030)1.80801443
132Morphological abnormality of the middle ear (HP:0008609)1.80711663
133Narrow nasal bridge (HP:0000446)1.80230643
134Limb dystonia (HP:0002451)1.80201708
135Mild short stature (HP:0003502)1.79928408
136Alopecia of scalp (HP:0002293)1.79155861
137Prolonged neonatal jaundice (HP:0006579)1.79105771
138Paraparesis (HP:0002385)1.79016071
139Interstitial pulmonary disease (HP:0006530)1.78015107
140Dysdiadochokinesis (HP:0002075)1.77543252
141Abnormal tarsal ossification (HP:0008369)1.77355237
142Neuronal loss in central nervous system (HP:0002529)1.76291396
143Scanning speech (HP:0002168)1.76197672
144Hydroureter (HP:0000072)1.75858052
145Ankle clonus (HP:0011448)1.75543347
146Palmoplantar hyperkeratosis (HP:0000972)1.75164876
147Slow saccadic eye movements (HP:0000514)1.74970230
148Medial flaring of the eyebrow (HP:0010747)1.74250892
149Plantar hyperkeratosis (HP:0007556)1.74149997
150Erythema (HP:0010783)1.73552139
151Irregular vertebral endplates (HP:0003301)1.73269135
152Abnormality of the phalanges of the 2nd finger (HP:0009541)1.72816217
153Flattened epiphyses (HP:0003071)1.71698259
154Aplasia involving bones of the extremities (HP:0009825)1.71216650
155Aplasia involving bones of the upper limbs (HP:0009823)1.71216650
156Aplasia of the phalanges of the hand (HP:0009802)1.71216650
157Right ventricular cardiomyopathy (HP:0011663)1.71074446
158Distal lower limb amyotrophy (HP:0008944)1.70128239
159Aplasia/hypoplasia of the femur (HP:0005613)1.70047103
160Abnormality of macrophages (HP:0004311)1.69944631
161Stridor (HP:0010307)1.69361371
162Submucous cleft hard palate (HP:0000176)1.67183426
163Nasolacrimal duct obstruction (HP:0000579)1.66628047
164Enlarged epiphyses (HP:0010580)1.66268663
165Abnormal rod and cone electroretinograms (HP:0008323)1.66175486
166Episodic fever (HP:0001954)1.66148214
167Abnormality of the incisor (HP:0000676)1.66022327
168Purpura (HP:0000979)1.65947739
169Neonatal death (HP:0003811)1.65504642
170Abnormality of the epiphysis of the femoral head (HP:0010574)1.65332210
171Protruding tongue (HP:0010808)1.64453972
172Blue irides (HP:0000635)1.64266042
173Dementia (HP:0000726)1.63919748
174Dysmetria (HP:0001310)1.63803380
175Torticollis (HP:0000473)1.63659671
176Conjugated hyperbilirubinemia (HP:0002908)1.62749886
177Attenuation of retinal blood vessels (HP:0007843)1.62321321
178Focal dystonia (HP:0004373)1.62294083
179Septo-optic dysplasia (HP:0100842)1.62074949
180Osteoarthritis (HP:0002758)1.61015998
181Congenital ichthyosiform erythroderma (HP:0007431)1.60883770
182Hypercortisolism (HP:0001578)1.60455366
183Aortic aneurysm (HP:0004942)1.60086429
184Hypertriglyceridemia (HP:0002155)1.60078210
185Cerebral aneurysm (HP:0004944)1.59903361
186Gait imbalance (HP:0002141)1.59855473
187Osteolytic defects of the hand bones (HP:0009699)1.58894355
188Osteolytic defects of the phalanges of the hand (HP:0009771)1.58894355
189Abnormality of the femoral head (HP:0003368)1.58654720
190Nonprogressive disorder (HP:0003680)1.58539316
191Congenital sensorineural hearing impairment (HP:0008527)1.58120424
192Tetraparesis (HP:0002273)1.57775718
193Cranial hyperostosis (HP:0004437)1.57401961
194Increased CSF protein (HP:0002922)1.57039869
195Craniofacial dystonia (HP:0012179)1.56798904
196Reduced subcutaneous adipose tissue (HP:0003758)1.55716966

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK4.47279633
2TESK13.77035456
3TNIK3.21129109
4NTRK33.05996724
5MST1R3.00944914
6MAP2K72.91921455
7MAP3K122.85746511
8RIPK12.70756751
9TXK2.65711293
10EPHA22.50098439
11SIK32.46897315
12BLK2.40544555
13IRAK32.25849560
14SIK22.02975028
15FES2.01687252
16ARAF1.94501974
17ERN11.92144994
18PRPF4B1.91735577
19EPHA41.91577712
20MUSK1.90303269
21LIMK11.87157896
22MAP3K131.83815544
23RIPK41.70227312
24MAP3K111.70057731
25PIM21.70009291
26MAP3K41.69056125
27TBK11.51295109
28GRK71.48267997
29PRKD31.44785272
30ADRBK21.42607117
31MOS1.41907303
32EPHB21.41415151
33MAP3K31.40879152
34NEK61.40233397
35TNK21.40059148
36MAPK131.37545282
37STK381.37398912
38GRK11.37349522
39LMTK21.36284250
40MKNK21.35569890
41MAP3K141.34298308
42PAK61.33952832
43ABL21.33023573
44STK161.26767473
45BMPR21.25893148
46MET1.25537541
47EPHB11.23165706
48TIE11.21522909
49CDK191.21442249
50PRKD21.20876643
51TEC1.19284060
52PTK21.19092147
53PLK21.18845782
54PIK3CA1.13535744
55PDGFRA1.12851958
56GRK51.11729046
57NME21.10618344
58UHMK11.07748207
59TYK21.06479215
60IRAK41.05962836
61KSR21.05613450
62NLK1.04498334
63TESK21.03989027
64CAMKK21.03973907
65NME11.03383506
66IRAK11.00016646
67PDPK10.96286624
68NUAK10.96141424
69MARK10.95568856
70CAMK2G0.95460553
71MAP2K40.94919802
72TGFBR20.93293528
73PINK10.89828507
74TAOK20.89274855
75IKBKE0.89063850
76DYRK1A0.87432097
77CAMK2A0.86009521
78PRKCE0.85369555
79BMPR1B0.85217858
80TRPM70.83307907
81MINK10.83017402
82MAP3K10.82517503
83INSRR0.82168841
84SGK20.82126166
85NTRK20.80989666
86CAMK10.80285020
87MAPK120.79575672
88JAK10.79553177
89PKN10.79002875
90ITK0.78553692
91FGR0.76668087
92PRKCQ0.75843213
93MYLK0.75583800
94MAP4K10.75349677
95CDC42BPA0.74988558
96DAPK30.74516862
97PRKCG0.73740331
98NTRK10.71832931
99MAP3K90.70806601
100MAP3K20.70723487
101FGFR40.70709906
102IRAK20.70455973
103YES10.69543654
104PDK10.68285653
105LATS20.68195162
106SYK0.67617232
107EPHA30.67067556
108CDK80.66648863
109PTK2B0.65549647
110PAK40.65368428
111CDK50.64856251
112CDK30.63445754
113CAMK2B0.63101706
114STK240.61983786
115LCK0.61743940
116MAP3K50.61741268
117PRKG10.60739271
118MARK20.60462764
119ROCK20.59617357
120IKBKB0.56895085
121EIF2AK20.56583097
122SGK4940.54569809
123SGK2230.54569809
124FYN0.51780438
125HCK0.51399551
126PDK20.51399019
127DAPK20.51069782
128ZAP700.50537358
129PHKG10.50348399
130PHKG20.50348399
131OXSR10.50219208
132PRKG20.49982529
133HIPK20.49778509
134MAP2K60.49715336
135ADRBK10.49570335
136WNK10.48820386
137TAOK10.48768073
138LYN0.47428012
139FGFR30.46973554
140CAMK2D0.45899152
141MAP2K30.45454419
142JAK30.45182351
143KIT0.45022135
144KSR10.44453034
145KDR0.44218882
146DYRK1B0.44122502
147SGK10.44086355
148GSK3A0.43317246
149TAOK30.43289388
150GRK60.42752834
151MAPK40.41887351
152PRKACA0.41614323
153MAPK70.40604011
154DAPK10.40375678
155ROCK10.39877206
156PRKCH0.38623161
157CDK140.38506867
158DDR20.36631209
159BTK0.36080662
160BCR0.34935842
161FER0.34868767

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.91372333
2Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.57640782
3Other glycan degradation_Homo sapiens_hsa005112.48878075
4Morphine addiction_Homo sapiens_hsa050322.44987008
5Glutamatergic synapse_Homo sapiens_hsa047242.32053741
6Sulfur metabolism_Homo sapiens_hsa009202.31945668
7Taste transduction_Homo sapiens_hsa047422.22855493
8Circadian entrainment_Homo sapiens_hsa047132.19577561
9GABAergic synapse_Homo sapiens_hsa047272.15306263
10Olfactory transduction_Homo sapiens_hsa047402.10588477
11Phototransduction_Homo sapiens_hsa047442.08533547
12Neuroactive ligand-receptor interaction_Homo sapiens_hsa040802.06480313
13Glycosaminoglycan degradation_Homo sapiens_hsa005312.06286108
14Salivary secretion_Homo sapiens_hsa049702.01922586
15Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.00255637
16Prion diseases_Homo sapiens_hsa050201.93942427
17Serotonergic synapse_Homo sapiens_hsa047261.87830095
18Synaptic vesicle cycle_Homo sapiens_hsa047211.85157114
19Complement and coagulation cascades_Homo sapiens_hsa046101.81530917
20Calcium signaling pathway_Homo sapiens_hsa040201.75909093
21Long-term potentiation_Homo sapiens_hsa047201.67192071
22Long-term depression_Homo sapiens_hsa047301.65755020
23Renin-angiotensin system_Homo sapiens_hsa046141.64773733
24Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.58400507
25Primary immunodeficiency_Homo sapiens_hsa053401.57739103
26Amphetamine addiction_Homo sapiens_hsa050311.57206918
27Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.53719569
28Lysosome_Homo sapiens_hsa041421.52703040
29Cholinergic synapse_Homo sapiens_hsa047251.49851970
30Dopaminergic synapse_Homo sapiens_hsa047281.48494633
31Renin secretion_Homo sapiens_hsa049241.45474405
32Arginine biosynthesis_Homo sapiens_hsa002201.45318840
33Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.39814485
34Histidine metabolism_Homo sapiens_hsa003401.39199679
35Insulin secretion_Homo sapiens_hsa049111.38716363
36Mineral absorption_Homo sapiens_hsa049781.37014690
37Oxytocin signaling pathway_Homo sapiens_hsa049211.36722034
38Vitamin B6 metabolism_Homo sapiens_hsa007501.33666604
39Pertussis_Homo sapiens_hsa051331.31666827
40Gastric acid secretion_Homo sapiens_hsa049711.26790058
41Aldosterone synthesis and secretion_Homo sapiens_hsa049251.26328940
42Collecting duct acid secretion_Homo sapiens_hsa049661.25518337
43Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.25165111
44Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.24860707
45Bile secretion_Homo sapiens_hsa049761.23224724
46Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.18632679
47Arginine and proline metabolism_Homo sapiens_hsa003301.16799863
48cAMP signaling pathway_Homo sapiens_hsa040241.13695101
49Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.13600513
50Pancreatic secretion_Homo sapiens_hsa049721.11134183
51Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.10042902
52PPAR signaling pathway_Homo sapiens_hsa033201.09463004
53Cocaine addiction_Homo sapiens_hsa050301.08962578
54T cell receptor signaling pathway_Homo sapiens_hsa046601.08464661
55Graft-versus-host disease_Homo sapiens_hsa053321.07261223
56Autoimmune thyroid disease_Homo sapiens_hsa053201.04176853
57Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.02625573
58SNARE interactions in vesicular transport_Homo sapiens_hsa041301.02357943
59Axon guidance_Homo sapiens_hsa043601.02276631
60Rheumatoid arthritis_Homo sapiens_hsa053231.01740750
61Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.01496625
62Endocytosis_Homo sapiens_hsa041441.01400572
63African trypanosomiasis_Homo sapiens_hsa051431.00070302
64Intestinal immune network for IgA production_Homo sapiens_hsa046720.99322903
65Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.97629029
66Allograft rejection_Homo sapiens_hsa053300.96023663
67Salmonella infection_Homo sapiens_hsa051320.94913543
68cGMP-PKG signaling pathway_Homo sapiens_hsa040220.93405141
69Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.91375795
70Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.89751489
71Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.87338076
72* Phosphatidylinositol signaling system_Homo sapiens_hsa040700.86378040
73Circadian rhythm_Homo sapiens_hsa047100.86144883
74Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.85801344
75Vascular smooth muscle contraction_Homo sapiens_hsa042700.84433326
76GnRH signaling pathway_Homo sapiens_hsa049120.84100176
77Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.83325085
78Phenylalanine metabolism_Homo sapiens_hsa003600.82764812
79Fatty acid degradation_Homo sapiens_hsa000710.81999690
80Fat digestion and absorption_Homo sapiens_hsa049750.81820402
81Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.81559942
82Sphingolipid metabolism_Homo sapiens_hsa006000.80615062
83Primary bile acid biosynthesis_Homo sapiens_hsa001200.80346841
84Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.80333310
85Fatty acid biosynthesis_Homo sapiens_hsa000610.80197589
86Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.80111242
87Chemokine signaling pathway_Homo sapiens_hsa040620.78209877
88Phagosome_Homo sapiens_hsa041450.77196137
89Amoebiasis_Homo sapiens_hsa051460.75981113
90Arachidonic acid metabolism_Homo sapiens_hsa005900.75887029
91Thyroid hormone synthesis_Homo sapiens_hsa049180.74746956
92Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.74721524
93MAPK signaling pathway_Homo sapiens_hsa040100.74382997
94Oxidative phosphorylation_Homo sapiens_hsa001900.74137644
95Ras signaling pathway_Homo sapiens_hsa040140.74120697
96Dilated cardiomyopathy_Homo sapiens_hsa054140.74106582
97Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.73549254
98Hematopoietic cell lineage_Homo sapiens_hsa046400.73526826
99Staphylococcus aureus infection_Homo sapiens_hsa051500.72048225
100Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.71741702
101Gap junction_Homo sapiens_hsa045400.71640306
102Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.71382619
103Folate biosynthesis_Homo sapiens_hsa007900.71013247
104Alzheimers disease_Homo sapiens_hsa050100.70435257
105Cyanoamino acid metabolism_Homo sapiens_hsa004600.70236301
106Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.69544116
107Cardiac muscle contraction_Homo sapiens_hsa042600.69448293
108Type II diabetes mellitus_Homo sapiens_hsa049300.67932318
109Type I diabetes mellitus_Homo sapiens_hsa049400.67362456
110Measles_Homo sapiens_hsa051620.67225947
111Adipocytokine signaling pathway_Homo sapiens_hsa049200.66179497
112Pentose and glucuronate interconversions_Homo sapiens_hsa000400.66040118
113Rap1 signaling pathway_Homo sapiens_hsa040150.65732784
114Glycerolipid metabolism_Homo sapiens_hsa005610.64257305
115TNF signaling pathway_Homo sapiens_hsa046680.62846245
116Starch and sucrose metabolism_Homo sapiens_hsa005000.62801634
117Fructose and mannose metabolism_Homo sapiens_hsa000510.62612645
118Phospholipase D signaling pathway_Homo sapiens_hsa040720.62553262
119Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.62262851
1202-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.62193557
121Platelet activation_Homo sapiens_hsa046110.61307299
122Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.61287920
123Choline metabolism in cancer_Homo sapiens_hsa052310.61020366
124Shigellosis_Homo sapiens_hsa051310.60049306
125Ovarian steroidogenesis_Homo sapiens_hsa049130.59406194
126Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.58626439
127Melanogenesis_Homo sapiens_hsa049160.58547906
128Protein digestion and absorption_Homo sapiens_hsa049740.58048410
129Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.56565723
130Chemical carcinogenesis_Homo sapiens_hsa052040.56332914
131Galactose metabolism_Homo sapiens_hsa000520.56209794
132Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.55286518
133Jak-STAT signaling pathway_Homo sapiens_hsa046300.55179365
134Tuberculosis_Homo sapiens_hsa051520.54805495
135Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.54015118
136Osteoclast differentiation_Homo sapiens_hsa043800.53272730
137Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.53259015
138NF-kappa B signaling pathway_Homo sapiens_hsa040640.53239153
139ErbB signaling pathway_Homo sapiens_hsa040120.52470546
140Drug metabolism - other enzymes_Homo sapiens_hsa009830.52202321
141B cell receptor signaling pathway_Homo sapiens_hsa046620.51285904
142Vibrio cholerae infection_Homo sapiens_hsa051100.50307804
143Glutathione metabolism_Homo sapiens_hsa004800.50288730
144ECM-receptor interaction_Homo sapiens_hsa045120.49879652
145Estrogen signaling pathway_Homo sapiens_hsa049150.49828834
146Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.47784817
147Sphingolipid signaling pathway_Homo sapiens_hsa040710.46571754
148Malaria_Homo sapiens_hsa051440.45031485
149Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.44365003
150Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.42970653
151Focal adhesion_Homo sapiens_hsa045100.42437594
152Legionellosis_Homo sapiens_hsa051340.42382208
153Bladder cancer_Homo sapiens_hsa052190.41524279
154Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.40512041
155Melanoma_Homo sapiens_hsa052180.40373469
156Leukocyte transendothelial migration_Homo sapiens_hsa046700.40137634
157Asthma_Homo sapiens_hsa053100.39470248
158Toll-like receptor signaling pathway_Homo sapiens_hsa046200.37477259
159Tyrosine metabolism_Homo sapiens_hsa003500.36552364

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