INPP4A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes an Mg++ independent enzyme that hydrolyzes the 4-position phosphate from the inositol ring of phosphatidylinositol 3,4-bisphosphate, inositol 1,3,4-trisphosphate, and inositol 3,4-bisphosphate. Multiple transcript variants encoding distinct isoforms have been described. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of leukocyte mediated cytotoxicity (GO:0001911)6.33124199
2negative regulation of cell killing (GO:0031342)6.33124199
3positive regulation of gamma-delta T cell activation (GO:0046645)5.85251909
4regulation of B cell receptor signaling pathway (GO:0050855)5.20713871
5presynaptic membrane assembly (GO:0097105)5.14394911
6antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.07306167
7synaptic vesicle exocytosis (GO:0016079)4.94251373
8antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.91723727
9synaptic vesicle docking involved in exocytosis (GO:0016081)4.87352690
10regulation of synaptic vesicle exocytosis (GO:2000300)4.83836414
11negative T cell selection (GO:0043383)4.81452885
12negative thymic T cell selection (GO:0045060)4.80797188
13neuronal action potential propagation (GO:0019227)4.70974442
14antigen processing and presentation of endogenous antigen (GO:0019883)4.60161792
15regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.59620648
16neurotransmitter-gated ion channel clustering (GO:0072578)4.57953292
17presynaptic membrane organization (GO:0097090)4.55617271
18antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.53775629
19postsynaptic membrane organization (GO:0001941)4.51959990
20negative regulation of dendrite morphogenesis (GO:0050774)4.47515106
21neuron cell-cell adhesion (GO:0007158)4.46190683
22glutamate secretion (GO:0014047)4.37430565
23regulation of short-term neuronal synaptic plasticity (GO:0048172)4.36920662
24positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.34145327
25positive T cell selection (GO:0043368)4.32233863
26regulation of synaptic vesicle transport (GO:1902803)4.31109481
27activated T cell proliferation (GO:0050798)4.29881857
28positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.27610509
29positive thymic T cell selection (GO:0045059)4.23388684
30vocalization behavior (GO:0071625)4.23356633
31regulation of gamma-delta T cell activation (GO:0046643)4.22909947
32regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.21126602
33response to interleukin-15 (GO:0070672)4.17706868
34T cell migration (GO:0072678)4.12890975
35regulation of gamma-delta T cell differentiation (GO:0045586)4.12878204
36positive regulation by symbiont of host defense response (GO:0052509)4.05381725
37modulation by symbiont of host defense response (GO:0052031)4.05381725
38modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.05381725
39modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.05381725
40positive regulation by organism of defense response of other organism involved in symbiotic interact4.05381725
41modulation by symbiont of host immune response (GO:0052553)4.05381725
42leukocyte aggregation (GO:0070486)4.01195167
43negative regulation of synaptic transmission, GABAergic (GO:0032229)3.95088494
44membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.95060237
45T cell selection (GO:0045058)3.94698443
46protein localization to synapse (GO:0035418)3.92440298
47inositol phosphate catabolic process (GO:0071545)3.91317624
48regulation of glutamate receptor signaling pathway (GO:1900449)3.91051567
49negative regulation of T cell mediated immunity (GO:0002710)3.87439493
50negative regulation of lymphocyte mediated immunity (GO:0002707)3.86088247
51thymic T cell selection (GO:0045061)3.84582039
52B cell receptor signaling pathway (GO:0050853)3.78396063
53synaptic transmission, glutamatergic (GO:0035249)3.76375654
54regulation of ARF protein signal transduction (GO:0032012)3.76319811
55synaptic vesicle maturation (GO:0016188)3.75793223
56negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.69209372
57cellular response to interleukin-15 (GO:0071350)3.67390613
58ionotropic glutamate receptor signaling pathway (GO:0035235)3.66702663
59neuron-neuron synaptic transmission (GO:0007270)3.65696907
60macrophage activation involved in immune response (GO:0002281)3.65432722
61cellular extravasation (GO:0045123)3.65373899
62neurotransmitter secretion (GO:0007269)3.58903897
63transferrin transport (GO:0033572)3.58627069
64antigen processing and presentation via MHC class Ib (GO:0002475)3.53890119
65negative regulation of leukocyte mediated immunity (GO:0002704)3.52003439
66negative regulation of dendrite development (GO:2000171)3.50244291
67positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.41316963
68detection of other organism (GO:0098543)3.37974759
69positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.37227813
70long-term synaptic potentiation (GO:0060291)3.35866605
71regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.34167917
72regulation of excitatory postsynaptic membrane potential (GO:0060079)3.34070445
73ferric iron transport (GO:0015682)3.32543459
74trivalent inorganic cation transport (GO:0072512)3.32543459
75glutamate receptor signaling pathway (GO:0007215)3.32432576
76positive regulation of granulocyte differentiation (GO:0030854)3.31918194
77locomotory exploration behavior (GO:0035641)3.31876724
78negative regulation of erythrocyte differentiation (GO:0045647)3.30609461
79positive regulation of membrane potential (GO:0045838)3.29790224
80positive regulation of Rap GTPase activity (GO:0032854)3.27520867
81regulation of neurotransmitter secretion (GO:0046928)3.26344457
82negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.25608338
83synaptic vesicle endocytosis (GO:0048488)3.25218567
84detection of calcium ion (GO:0005513)3.25195319
85regulation of B cell differentiation (GO:0045577)3.22798780
86positive regulation of synaptic transmission, GABAergic (GO:0032230)3.19307199
87mechanosensory behavior (GO:0007638)3.18583023
88response to muramyl dipeptide (GO:0032495)3.16622631
89startle response (GO:0001964)3.16196573
90detection of bacterium (GO:0016045)3.16136411
91regulation of neuronal synaptic plasticity (GO:0048168)3.16055139
92regulation of postsynaptic membrane potential (GO:0060078)3.14283353
93interferon-gamma production (GO:0032609)3.12128186
94microglial cell activation (GO:0001774)3.10999140
95energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)3.10348215
96ATP hydrolysis coupled proton transport (GO:0015991)3.10348215
97positive regulation of B cell differentiation (GO:0045579)3.10127838
98membrane depolarization during action potential (GO:0086010)3.09793002
99histone H3-K36 demethylation (GO:0070544)3.09514480
100cerebellar Purkinje cell differentiation (GO:0021702)3.06415180
101gamma-aminobutyric acid signaling pathway (GO:0007214)3.05269516
102regulation of synaptic transmission, glutamatergic (GO:0051966)3.05213461
103regulation of synaptic transmission, GABAergic (GO:0032228)3.03210698
104phosphorylated carbohydrate dephosphorylation (GO:0046838)3.02271343
105inositol phosphate dephosphorylation (GO:0046855)3.02271343
106phagosome maturation (GO:0090382)3.01039015
107regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.99740746
108urinary tract smooth muscle contraction (GO:0014848)2.99532379
109cerebellar granule cell differentiation (GO:0021707)2.99295775
110positive regulation of neurotransmitter transport (GO:0051590)2.99200387
111regulation of long-term neuronal synaptic plasticity (GO:0048169)2.97790841
112regulation of neurotransmitter transport (GO:0051588)2.96241044
113detection of molecule of bacterial origin (GO:0032490)2.95266100
114signal complex assembly (GO:0007172)2.93747900
115gamma-aminobutyric acid transport (GO:0015812)2.93708011
116regulation of Rap GTPase activity (GO:0032317)2.92561090
117negative regulation of neurotransmitter secretion (GO:0046929)2.91935377
118positive regulation of neurotransmitter secretion (GO:0001956)2.91438341
119regulation of vesicle fusion (GO:0031338)2.90785819
120detection of external biotic stimulus (GO:0098581)2.90453070
121calcium ion-dependent exocytosis (GO:0017156)2.90418643
122regulation of synaptic plasticity (GO:0048167)2.89929715
123female mating behavior (GO:0060180)2.89772699
124regulation of alpha-beta T cell proliferation (GO:0046640)2.89686669
125membrane depolarization (GO:0051899)2.89167883
126neurotransmitter transport (GO:0006836)2.86868944
127positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.86713878
128establishment of synaptic vesicle localization (GO:0097480)2.83736964
129synaptic vesicle transport (GO:0048489)2.83736964
130negative regulation of interleukin-12 production (GO:0032695)2.82616695
131response to host immune response (GO:0052572)2.82240414
132response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.82240414
133myeloid cell activation involved in immune response (GO:0002275)2.82080484
134negative regulation of neurotransmitter transport (GO:0051589)2.81740172
135* phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.81653091
136exploration behavior (GO:0035640)2.81050819
137protein localization to cilium (GO:0061512)2.79960984
138regulation of T cell tolerance induction (GO:0002664)2.79864724
139antigen receptor-mediated signaling pathway (GO:0050851)2.79711865
140synapse assembly (GO:0007416)2.79441682
141positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.76363948
142G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.75732849
143histone H3-K4 trimethylation (GO:0080182)2.75474814
144neuronal action potential (GO:0019228)2.75340531
145auditory behavior (GO:0031223)2.74123698
146negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.74057411
147innervation (GO:0060384)2.73855119
148regulation of interferon-beta biosynthetic process (GO:0045357)2.71937820
149regulation of tolerance induction (GO:0002643)2.70701140
150positive regulation of synaptic transmission (GO:0050806)2.70280395
151long-term memory (GO:0007616)2.68960512
152serotonin metabolic process (GO:0042428)2.68576051
153regulation of female receptivity (GO:0045924)2.68075753
154T cell receptor signaling pathway (GO:0050852)2.67663727
155regulation of exocytosis (GO:0017157)2.67573806
156regulation of glutamate secretion (GO:0014048)2.67370268
157synaptic transmission (GO:0007268)2.67130913
158myeloid leukocyte mediated immunity (GO:0002444)2.66659998
159regulation of granulocyte differentiation (GO:0030852)2.66450337
160learning (GO:0007612)2.66433960
161proline transport (GO:0015824)2.66047089
162positive regulation of amino acid transport (GO:0051957)2.65742507
163response to host (GO:0075136)2.65455832
164response to host defenses (GO:0052200)2.65455832
165response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.65455832
166macrophage activation (GO:0042116)2.64548691
167neutrophil activation involved in immune response (GO:0002283)2.64305765
168activation of protein kinase A activity (GO:0034199)2.63666635
169cellular response to ethanol (GO:0071361)2.63261867
170regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.62938802
171regulation of natural killer cell mediated immunity (GO:0002715)2.62938802
172dendrite development (GO:0016358)2.62659797
173natural killer cell differentiation (GO:0001779)2.62641719
174insulin secretion (GO:0030073)2.62548712
175T cell homeostasis (GO:0043029)2.62388917
176regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.61592408
177vesicle docking involved in exocytosis (GO:0006904)2.60053272
178positive regulation of synapse assembly (GO:0051965)2.59520047
179regulation of synaptic transmission (GO:0050804)2.58999466
180B cell homeostasis (GO:0001782)2.58777383
181mast cell activation (GO:0045576)2.58773086
182regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.57614462
183tolerance induction (GO:0002507)2.57461732
184regulation of beta-amyloid formation (GO:1902003)2.54793138
185regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.52055872
186neutrophil mediated immunity (GO:0002446)2.51837224
187detection of biotic stimulus (GO:0009595)2.51126232
188negative regulation of B cell proliferation (GO:0030889)2.49954985
189positive regulation of mast cell activation (GO:0033005)2.49569667
190regulation of isotype switching to IgG isotypes (GO:0048302)2.48643550
191mucosal-associated lymphoid tissue development (GO:0048537)2.48436166
192Peyers patch development (GO:0048541)2.48436166
193negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.48401415
194L-amino acid import (GO:0043092)2.45845900
195negative regulation of adaptive immune response (GO:0002820)2.45689526
196regulation of regulated secretory pathway (GO:1903305)2.45364798
197positive regulation of alpha-beta T cell proliferation (GO:0046641)2.44850314

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.95555029
2STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.79864144
3GBX2_23144817_ChIP-Seq_PC3_Human4.70854718
4FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.37549017
5IRF8_22096565_ChIP-ChIP_GC-B_Human3.54772155
6RUNX_20019798_ChIP-Seq_JUKART_Human3.35935984
7TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.93321726
8* MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.83983387
9FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.76260626
10STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.67571850
11SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.64995821
12SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.55268569
13TAF15_26573619_Chip-Seq_HEK293_Human2.50319943
14SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.41269252
15REST_21632747_ChIP-Seq_MESCs_Mouse2.40862084
16JARID2_20064375_ChIP-Seq_MESCs_Mouse2.37562343
17ZFP57_27257070_Chip-Seq_ESCs_Mouse2.37203765
18MYC_22102868_ChIP-Seq_BL_Human2.36945008
19SCL_19346495_ChIP-Seq_HPC-7_Human2.35032118
20IRF8_27001747_Chip-Seq_BMDM_Mouse2.34801237
21BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.33868874
22KDM2B_26808549_Chip-Seq_SUP-B15_Human2.32882948
23NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.32557891
24IRF8_21731497_ChIP-ChIP_J774_Mouse2.26031456
25* TCF7_22412390_ChIP-Seq_EML_Mouse2.16077520
26SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.15826608
27* MYB_26560356_Chip-Seq_TH2_Human2.15654852
28GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.10802493
29KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.10709519
30POU3F2_20337985_ChIP-ChIP_501MEL_Human2.08766467
31MAF_26560356_Chip-Seq_TH1_Human2.08460616
32EZH2_27304074_Chip-Seq_ESCs_Mouse2.08392842
33NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.07295886
34JARID2_20075857_ChIP-Seq_MESCs_Mouse2.05542882
35KDM2B_26808549_Chip-Seq_DND41_Human2.04348549
36SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.03845587
37CTBP2_25329375_ChIP-Seq_LNCAP_Human2.02839091
38VDR_21846776_ChIP-Seq_THP-1_Human2.01782272
39GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.00916137
40MYB_21317192_ChIP-Seq_ERMYB_Mouse2.00422320
41* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.00173551
42* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.99542163
43* SPI1_23127762_ChIP-Seq_K562_Human1.99340733
44SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.98470088
45* IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.96992996
46* SMAD4_21799915_ChIP-Seq_A2780_Human1.96212855
47P300_19829295_ChIP-Seq_ESCs_Human1.94184394
48RNF2_18974828_ChIP-Seq_MESCs_Mouse1.93207680
49EZH2_18974828_ChIP-Seq_MESCs_Mouse1.93207680
50NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.90927155
51VDR_24763502_ChIP-Seq_THP-1_Human1.90559380
52* REST_18959480_ChIP-ChIP_MESCs_Mouse1.88128998
53EED_16625203_ChIP-ChIP_MESCs_Mouse1.86718310
54SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.86066705
55KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.85914314
56MTF2_20144788_ChIP-Seq_MESCs_Mouse1.85743348
57MYB_26560356_Chip-Seq_TH1_Human1.83418624
58* UTX_26944678_Chip-Seq_JUKART_Human1.81561326
59BMI1_23680149_ChIP-Seq_NPCS_Mouse1.81480353
60PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.80546456
61CTBP1_25329375_ChIP-Seq_LNCAP_Human1.78832406
62DROSHA_22980978_ChIP-Seq_HELA_Human1.77253744
63EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.77247951
64KDM2B_26808549_Chip-Seq_JURKAT_Human1.77044118
65CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.73817211
66GATA3_27048872_Chip-Seq_THYMUS_Human1.73383935
67EZH2_27294783_Chip-Seq_ESCs_Mouse1.71296643
68RARB_27405468_Chip-Seq_BRAIN_Mouse1.70695983
69GATA1_22025678_ChIP-Seq_K562_Human1.70609058
70SUZ12_27294783_Chip-Seq_ESCs_Mouse1.67871978
71RNF2_27304074_Chip-Seq_ESCs_Mouse1.67194852
72GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.66961454
73SMAD_19615063_ChIP-ChIP_OVARY_Human1.65989554
74BRD4_27068464_Chip-Seq_AML-cells_Mouse1.63904582
75GATA1_19941827_ChIP-Seq_MEL_Mouse1.58092268
76PIAS1_25552417_ChIP-Seq_VCAP_Human1.57446662
77RUNX1_22412390_ChIP-Seq_EML_Mouse1.56064106
78STAT3_23295773_ChIP-Seq_U87_Human1.54048706
79TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.53428378
80IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.50870286
81TOP2B_26459242_ChIP-Seq_MCF-7_Human1.50611572
82MAF_26560356_Chip-Seq_TH2_Human1.49342069
83IKZF1_21737484_ChIP-ChIP_HCT116_Human1.49035838
84EGR1_19374776_ChIP-ChIP_THP-1_Human1.48108857
85OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.47849780
86RNF2_27304074_Chip-Seq_NSC_Mouse1.47341908
87AR_25329375_ChIP-Seq_VCAP_Human1.47161861
88VDR_24787735_ChIP-Seq_THP-1_Human1.45662284
89AR_21572438_ChIP-Seq_LNCaP_Human1.45490814
90THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.44980775
91SMAD3_21741376_ChIP-Seq_EPCs_Human1.42872350
92KDM2B_26808549_Chip-Seq_K562_Human1.40760551
93* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.40411835
94IGF1R_20145208_ChIP-Seq_DFB_Human1.40344487
95BP1_19119308_ChIP-ChIP_Hs578T_Human1.39861868
96* NANOG_18555785_Chip-Seq_ESCs_Mouse1.39495305
97RBPJ_22232070_ChIP-Seq_NCS_Mouse1.39209459
98Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.39097533
99SPI1_23547873_ChIP-Seq_NB4_Human1.39001756
100CBX2_27304074_Chip-Seq_ESCs_Mouse1.38204212
101* TCF4_23295773_ChIP-Seq_U87_Human1.37521216
102VDR_22108803_ChIP-Seq_LS180_Human1.37204183
103STAT4_19710469_ChIP-ChIP_TH1__Mouse1.37076244
104SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.36524273
105* FLI1_27457419_Chip-Seq_LIVER_Mouse1.36102104
106AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.34589078
107* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.33484253
108RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.33271909
109* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.31716200
110NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.31014759
111RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.30985742
112* PCGF2_27294783_Chip-Seq_ESCs_Mouse1.29931260
113SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.29340761
114* P53_22387025_ChIP-Seq_ESCs_Mouse1.28899024
115NR3C1_23031785_ChIP-Seq_PC12_Mouse1.27904062
116SOX2_21211035_ChIP-Seq_LN229_Gbm1.27410590
117MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.27055448
118* E2F1_18555785_Chip-Seq_ESCs_Mouse1.26857899
119ER_23166858_ChIP-Seq_MCF-7_Human1.25281938
120* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.24947054
121GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.24538512
122* RUNX2_22187159_ChIP-Seq_PCA_Human1.22630827
123ARNT_22903824_ChIP-Seq_MCF-7_Human1.21844603
124FUS_26573619_Chip-Seq_HEK293_Human1.20224157
125* PU_27001747_Chip-Seq_BMDM_Mouse1.19454703
126GATA1_19941826_ChIP-Seq_K562_Human1.18759924
127CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.18399786
128* STAT3_18555785_Chip-Seq_ESCs_Mouse1.18064627
129* DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.17662733
130ZFP281_27345836_Chip-Seq_ESCs_Mouse1.17553824
131* CMYC_18555785_Chip-Seq_ESCs_Mouse1.16749843
132TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.16590266
133* SUZ12_18555785_Chip-Seq_ESCs_Mouse1.16375099
134STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.16252843
135ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.15505749
136AHR_22903824_ChIP-Seq_MCF-7_Human1.14800040
137PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.14554339
138CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.13254446
139FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.11305195
140KDM2B_26808549_Chip-Seq_REH_Human1.10709471
141PRDM14_20953172_ChIP-Seq_ESCs_Human1.10539287
142* VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.10376490
143RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.10142803
144* SOX2_18555785_Chip-Seq_ESCs_Mouse1.08941580
145* P300_18555785_Chip-Seq_ESCs_Mouse1.08741651
146MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.08138966
147* EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.07660786
148UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.07558777
149JUN_21703547_ChIP-Seq_K562_Human1.06565572
150* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.06355385
151PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.06276325
152* NMYC_18555785_Chip-Seq_ESCs_Mouse1.06143749
153TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.05848095
154* RUNX1_27457419_Chip-Seq_LIVER_Mouse1.05371351
155* SUZ12_27294783_Chip-Seq_NPCs_Mouse1.05145612
156TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04675760
157CDX2_19796622_ChIP-Seq_MESCs_Mouse1.03497092
158RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.02658122
159POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.02291513
160TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02291513
161PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.02161589
162MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.01447391
163MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.00721604
164ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.00090001
165* GATA1_19941827_ChIP-Seq_MEL86_Mouse0.97893227
166GATA3_26560356_Chip-Seq_TH2_Human0.91801348
167* GATA2_19941826_ChIP-Seq_K562_Human0.91452894
168CTNNB1_20460455_ChIP-Seq_HCT116_Human0.91039850
169LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.90744002
170* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.88412560
171NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.87210871
172PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.85112264
173SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.80279788
174GATA2_22383799_ChIP-Seq_G1ME_Mouse0.79745451
175RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.78886401
176ZFP281_18757296_ChIP-ChIP_E14_Mouse0.77882041
177EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.75617600
178SMRT_27268052_Chip-Seq_Bcells_Human0.75294726
179GATA2_21666600_ChIP-Seq_HMVEC_Human0.71993002
180* TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.71234778
181KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.70986421
182WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.70646143
183DNAJC2_21179169_ChIP-ChIP_NT2_Human0.70003354
184LXR_22292898_ChIP-Seq_THP-1_Human0.69784197

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern4.36047200
2MP0004859_abnormal_synaptic_plasticity4.19542036
3MP0003763_abnormal_thymus_physiology3.74413892
4MP0004270_analgesia3.57991558
5MP0001835_abnormal_antigen_presentation3.54173782
6* MP0003635_abnormal_synaptic_transmissio3.29728232
7MP0001968_abnormal_touch/_nociception3.14234769
8MP0005671_abnormal_response_to3.07225424
9MP0009046_muscle_twitch3.04570205
10MP0009745_abnormal_behavioral_response3.00349979
11MP0002735_abnormal_chemical_nociception2.94422125
12MP0005646_abnormal_pituitary_gland2.93372368
13MP0003303_peritoneal_inflammation2.92808505
14MP0003436_decreased_susceptibility_to2.92229491
15MP0003724_increased_susceptibility_to2.85514182
16MP0002064_seizures2.84656201
17MP0002734_abnormal_mechanical_nocicepti2.80968489
18MP0002063_abnormal_learning/memory/cond2.76392249
19MP0002736_abnormal_nociception_after2.74178147
20MP0001800_abnormal_humoral_immune2.73290011
21MP0002272_abnormal_nervous_system2.60705099
22MP0002572_abnormal_emotion/affect_behav2.60475480
23MP0000685_abnormal_immune_system2.55593842
24MP0003183_abnormal_peptide_metabolism2.47940050
25MP0001188_hyperpigmentation2.35070278
26MP0009780_abnormal_chondrocyte_physiolo2.34160194
27MP0003787_abnormal_imprinting2.34131886
28MP0001986_abnormal_taste_sensitivity2.28293142
29MP0002420_abnormal_adaptive_immunity2.27910107
30MP0005000_abnormal_immune_tolerance2.25640206
31MP0001819_abnormal_immune_cell2.24257634
32MP0002876_abnormal_thyroid_physiology2.21636037
33MP0005387_immune_system_phenotype2.19540651
34MP0001790_abnormal_immune_system2.19540651
35MP0002419_abnormal_innate_immunity2.18722568
36MP0005645_abnormal_hypothalamus_physiol2.17021274
37MP0002723_abnormal_immune_serum2.16241115
38MP0010386_abnormal_urinary_bladder2.16134653
39MP0003172_abnormal_lysosome_physiology2.14141468
40MP0003300_gastrointestinal_ulcer2.14139402
41MP0003690_abnormal_glial_cell2.13945678
42MP0002396_abnormal_hematopoietic_system2.11658860
43* MP0002067_abnormal_sensory_capabilities2.10792784
44MP0006276_abnormal_autonomic_nervous2.10640743
45MP0001486_abnormal_startle_reflex2.10383361
46MP0005025_abnormal_response_to2.07987349
47MP0002452_abnormal_antigen_presenting2.05778938
48MP0002398_abnormal_bone_marrow2.03857301
49MP0001984_abnormal_olfaction2.02555494
50MP0002733_abnormal_thermal_nociception2.01770978
51MP0000703_abnormal_thymus_morphology2.01500463
52MP0006082_CNS_inflammation2.00084021
53MP0003879_abnormal_hair_cell1.99697009
54MP0001970_abnormal_pain_threshold1.99454396
55MP0001501_abnormal_sleep_pattern1.99333933
56MP0004381_abnormal_hair_follicle1.91117520
57MP0000716_abnormal_immune_system1.84410616
58MP0002822_catalepsy1.79243023
59MP0002009_preneoplasia1.71753020
60MP0005423_abnormal_somatic_nervous1.71124922
61MP0002184_abnormal_innervation1.66884371
62MP0002557_abnormal_social/conspecific_i1.66758876
63MP0003866_abnormal_defecation1.66541446
64MP0004130_abnormal_muscle_cell1.63835677
65MP0002405_respiratory_system_inflammati1.59104207
66MP0001440_abnormal_grooming_behavior1.58961491
67MP0002722_abnormal_immune_system1.57032475
68MP0003122_maternal_imprinting1.55922450
69MP0002909_abnormal_adrenal_gland1.55412472
70MP0000689_abnormal_spleen_morphology1.54598447
71MP0005464_abnormal_platelet_physiology1.53031411
72MP0005386_behavior/neurological_phenoty1.49486939
73MP0004924_abnormal_behavior1.49486939
74MP0002166_altered_tumor_susceptibility1.46580708
75MP0000778_abnormal_nervous_system1.45739296
76* MP0008569_lethality_at_weaning1.44288741
77MP0004811_abnormal_neuron_physiology1.43599094
78MP0004043_abnormal_pH_regulation1.40365281
79MP0001502_abnormal_circadian_rhythm1.38868126
80MP0001905_abnormal_dopamine_level1.37839838
81MP0001529_abnormal_vocalization1.37512839
82MP0002429_abnormal_blood_cell1.37462822
83MP0001851_eye_inflammation1.37125283
84MP0000015_abnormal_ear_pigmentation1.35835092
85MP0008057_abnormal_DNA_replication1.30924415
86MP0000955_abnormal_spinal_cord1.28902593
87MP0005171_absent_coat_pigmentation1.28599669
88MP0009333_abnormal_splenocyte_physiolog1.26842175
89MP0003828_pulmonary_edema1.24550501
90MP0009785_altered_susceptibility_to1.24063881
91MP0004947_skin_inflammation1.22663651
92MP0003633_abnormal_nervous_system1.19817035
93MP0000013_abnormal_adipose_tissue1.18916715
94* MP0002882_abnormal_neuron_morphology1.18893658
95* MP0002066_abnormal_motor_capabilities/c1.17279458
96MP0002751_abnormal_autonomic_nervous1.17007590
97MP0003045_fibrosis1.16020859
98MP0010155_abnormal_intestine_physiology1.12029114
99MP0002998_abnormal_bone_remodeling1.11200530
100MP0004858_abnormal_nervous_system1.10835750
101* MP0004142_abnormal_muscle_tone1.10405057
102MP0001533_abnormal_skeleton_physiology1.10194111
103MP0004808_abnormal_hematopoietic_stem1.09926433
104MP0002837_dystrophic_cardiac_calcinosis1.09098038
105MP0000920_abnormal_myelination1.07418054
106MP0000631_abnormal_neuroendocrine_gland1.06651996
107MP0001845_abnormal_inflammatory_respons1.05860998
108MP0002693_abnormal_pancreas_physiology1.04715568
109MP0000604_amyloidosis1.03095134
110MP0002638_abnormal_pupillary_reflex1.02796896
111MP0005379_endocrine/exocrine_gland_phen1.02662203
112MP0009278_abnormal_bone_marrow1.00277656
113MP0002148_abnormal_hypersensitivity_rea0.99788465
114MP0004883_abnormal_blood_vessel0.99011781
115MP0000465_gastrointestinal_hemorrhage0.98828747
116MP0006292_abnormal_olfactory_placode0.98464881
117MP0001963_abnormal_hearing_physiology0.97930876
118MP0001348_abnormal_lacrimal_gland0.96757697
119* MP0002229_neurodegeneration0.95624622
120MP0005451_abnormal_body_composition0.95365749
121MP0003091_abnormal_cell_migration0.94734691
122MP0003631_nervous_system_phenotype0.94439968
123MP0008260_abnormal_autophagy0.93706469
124MP0000681_abnormal_thyroid_gland0.93033579
125MP0004742_abnormal_vestibular_system0.92670237
126MP0005535_abnormal_body_temperature0.92385964
127MP0005075_abnormal_melanosome_morpholog0.91574898
128MP0000372_irregular_coat_pigmentation0.90785850
129MP0002069_abnormal_eating/drinking_beha0.89838986
130MP0005076_abnormal_cell_differentiation0.86449070
131MP0005409_darkened_coat_color0.84848002
132MP0005551_abnormal_eye_electrophysiolog0.84350350
133MP0004510_myositis0.83891255
134MP0002006_tumorigenesis0.83102254
135MP0008877_abnormal_DNA_methylation0.80568082
136MP0002933_joint_inflammation0.79938625
137MP0001664_abnormal_digestion0.79065918
138MP0005394_taste/olfaction_phenotype0.78656893
139MP0005499_abnormal_olfactory_system0.78656893
140MP0000858_altered_metastatic_potential0.78586160
141MP0002877_abnormal_melanocyte_morpholog0.77768964
142MP0005174_abnormal_tail_pigmentation0.76882698
143MP0003136_yellow_coat_color0.75408253
144MP0000678_abnormal_parathyroid_gland0.74749718
145MP0004145_abnormal_muscle_electrophysio0.74720863
146MP0001873_stomach_inflammation0.73364966
147MP0003221_abnormal_cardiomyocyte_apopto0.72080282
148MP0004085_abnormal_heartbeat0.71677369
149* MP0002152_abnormal_brain_morphology0.71657785
150MP0000569_abnormal_digit_pigmentation0.71583601
151MP0001177_atelectasis0.69623357
152MP0003195_calcinosis0.69601474
153MP0003632_abnormal_nervous_system0.69175685
154MP0009697_abnormal_copulation0.68810689
155MP0001944_abnormal_pancreas_morphology0.68423480
156MP0003656_abnormal_erythrocyte_physiolo0.67885310
157MP0002752_abnormal_somatic_nervous0.67055021
158MP0005397_hematopoietic_system_phenotyp0.66896266
159MP0001485_abnormal_pinna_reflex0.65308714
160MP0008874_decreased_physiological_sensi0.62476745
161MP0005310_abnormal_salivary_gland0.61409145
162MP0000026_abnormal_inner_ear0.61269836
163MP0002078_abnormal_glucose_homeostasis0.60784343
164MP0003953_abnormal_hormone_level0.60175838
165MP0003329_amyloid_beta_deposits0.58728403
166MP0004885_abnormal_endolymph0.58579663
167* MP0003634_abnormal_glial_cell0.58196590
168MP0002163_abnormal_gland_morphology0.57065338

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)7.09999884
2Febrile seizures (HP:0002373)5.48782664
3Atonic seizures (HP:0010819)5.40733323
4Epileptic encephalopathy (HP:0200134)5.17065347
5Eczematoid dermatitis (HP:0000976)5.00359795
6Recurrent bacterial skin infections (HP:0005406)4.25786882
7Focal seizures (HP:0007359)4.24596880
8T lymphocytopenia (HP:0005403)4.22268161
9Hypothermia (HP:0002045)4.18731480
10Abnormality of T cell number (HP:0011839)4.11465906
11Myokymia (HP:0002411)4.08608975
12Recurrent abscess formation (HP:0002722)4.03656665
13Abnormal delayed hypersensitivity skin test (HP:0002963)4.01650218
14Progressive cerebellar ataxia (HP:0002073)3.97894366
15Papilledema (HP:0001085)3.86782848
16Abnormal hair whorl (HP:0010721)3.83836503
17Hyperventilation (HP:0002883)3.83665465
18Parkinsonism with favorable response to dopaminergic medication (HP:0002548)3.75411845
19Pheochromocytoma (HP:0002666)3.61527780
20Absence seizures (HP:0002121)3.58980878
21Visual hallucinations (HP:0002367)3.58269762
22Gaze-evoked nystagmus (HP:0000640)3.46419565
23Abnormality of the fingertips (HP:0001211)3.44507074
24Myositis (HP:0100614)3.43877162
25Spontaneous hematomas (HP:0007420)3.42646740
26Dialeptic seizures (HP:0011146)3.40056796
27Neuroendocrine neoplasm (HP:0100634)3.38343210
28Recurrent fungal infections (HP:0002841)3.30895730
29Optic neuritis (HP:0100653)3.20244155
30Retrobulbar optic neuritis (HP:0100654)3.20244155
31Gait imbalance (HP:0002141)3.19512222
32Generalized tonic-clonic seizures (HP:0002069)3.19283789
33Hemiplegia (HP:0002301)3.16812652
34Medial flaring of the eyebrow (HP:0010747)3.15920665
35Meningitis (HP:0001287)3.13017410
36Abnormality of macrophages (HP:0004311)3.09461254
37Chronic mucocutaneous candidiasis (HP:0002728)3.06032758
38Recurrent cutaneous fungal infections (HP:0011370)3.06032758
39Slow saccadic eye movements (HP:0000514)3.04652314
40Orchitis (HP:0100796)3.02969494
41Congenital primary aphakia (HP:0007707)2.99585333
42Gastrointestinal infarctions (HP:0005244)2.99040007
43Failure to thrive in infancy (HP:0001531)2.97705402
44Nephrogenic diabetes insipidus (HP:0009806)2.97495670
45Broad-based gait (HP:0002136)2.93004054
46Panhypogammaglobulinemia (HP:0003139)2.91190649
47Mediastinal lymphadenopathy (HP:0100721)2.90093977
48Elevated erythrocyte sedimentation rate (HP:0003565)2.88623412
49Recurrent skin infections (HP:0001581)2.86137776
50Abnormality of T cells (HP:0002843)2.80294576
51Epileptiform EEG discharges (HP:0011182)2.80034304
52Stomatitis (HP:0010280)2.80013980
53Recurrent gram-negative bacterial infections (HP:0005420)2.79979410
54Encephalitis (HP:0002383)2.77214042
55Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.74545676
56Fetal akinesia sequence (HP:0001989)2.71054084
57Recurrent viral infections (HP:0004429)2.70751912
58Blue irides (HP:0000635)2.70197801
59Poor suck (HP:0002033)2.69138209
60Gingivitis (HP:0000230)2.65349069
61Colitis (HP:0002583)2.64646924
62Abnormal eating behavior (HP:0100738)2.60274454
63Inflammation of the large intestine (HP:0002037)2.59464606
64Protruding tongue (HP:0010808)2.56918600
65Gastrointestinal inflammation (HP:0004386)2.53133559
66Vasculitis (HP:0002633)2.52810656
67EEG with generalized epileptiform discharges (HP:0011198)2.51620808
68Oligomenorrhea (HP:0000876)2.46598092
69Postural instability (HP:0002172)2.45415892
70Truncal ataxia (HP:0002078)2.45232853
71Scanning speech (HP:0002168)2.44510485
72Autoimmune hemolytic anemia (HP:0001890)2.43381181
73Pustule (HP:0200039)2.40872673
74Chest pain (HP:0100749)2.40506872
75Akinesia (HP:0002304)2.38117953
76Cellulitis (HP:0100658)2.37716452
77Polyphagia (HP:0002591)2.37054088
78Action tremor (HP:0002345)2.36781451
79Obstructive sleep apnea (HP:0002870)2.36631425
80Chronic obstructive pulmonary disease (HP:0006510)2.33921257
81Obstructive lung disease (HP:0006536)2.33921257
82Hypsarrhythmia (HP:0002521)2.33823429
83Bradycardia (HP:0001662)2.33822117
84Limb dystonia (HP:0002451)2.30357016
85Poor coordination (HP:0002370)2.29688642
86Keratoconjunctivitis sicca (HP:0001097)2.29555056
87Prolonged bleeding time (HP:0003010)2.28936147
88Amblyopia (HP:0000646)2.27632387
89Genetic anticipation (HP:0003743)2.27556798
90Genital tract atresia (HP:0001827)2.25139347
91Impaired vibration sensation in the lower limbs (HP:0002166)2.24987060
92Recurrent bronchitis (HP:0002837)2.23822510
93Dysdiadochokinesis (HP:0002075)2.23070726
94Vaginal atresia (HP:0000148)2.21912778
95Hypochromic anemia (HP:0001931)2.21867247
96Depression (HP:0000716)2.21001460
97Leukocytosis (HP:0001974)2.20888922
98Subacute progressive viral hepatitis (HP:0006572)2.18004301
99Anxiety (HP:0000739)2.17748452
100Autoimmune thrombocytopenia (HP:0001973)2.17721626
101Viral hepatitis (HP:0006562)2.16222381
102Urinary bladder sphincter dysfunction (HP:0002839)2.15740481
103Increased IgE level (HP:0003212)2.15605663
104Progressive inability to walk (HP:0002505)2.14797457
105Impaired smooth pursuit (HP:0007772)2.13685074
106Absent speech (HP:0001344)2.12860808
107Cortical visual impairment (HP:0100704)2.12173904
108Specific learning disability (HP:0001328)2.10010382
109Agitation (HP:0000713)2.08365166
110Urticaria (HP:0001025)2.07907728
111Keratoconjunctivitis (HP:0001096)2.06185243
112Abnormality of calcium-phosphate metabolism (HP:0100530)2.05891050
113Difficulty running (HP:0009046)2.04590805
114Granulocytopenia (HP:0001913)2.04299311
115Neuronal loss in central nervous system (HP:0002529)2.03900833
116Gingival bleeding (HP:0000225)2.03869656
117Abnormality of cells of the lymphoid lineage (HP:0012140)2.01815224
118Agammaglobulinemia (HP:0004432)2.01661436
119Hemoptysis (HP:0002105)2.00490318
120Spinal canal stenosis (HP:0003416)1.99463811
121Drooling (HP:0002307)1.99024421
122Excessive salivation (HP:0003781)1.99024421
123Lymphopenia (HP:0001888)1.98772798
124Generalized hypopigmentation of hair (HP:0011358)1.98752081
125IgM deficiency (HP:0002850)1.97645351
126Annular pancreas (HP:0001734)1.96900464
127Ankle clonus (HP:0011448)1.96508020
128Pulmonary embolism (HP:0002204)1.95677145
129Aplasia/Hypoplasia of the fovea (HP:0008060)1.95527558
130Hypoplasia of the fovea (HP:0007750)1.95527558
131Basal cell carcinoma (HP:0002671)1.93209929
132Arterial thrombosis (HP:0004420)1.93092751
133Epistaxis (HP:0000421)1.93031932
134Abnormality of T cell physiology (HP:0011840)1.92620097
135Symptomatic seizures (HP:0011145)1.92429626
136Esotropia (HP:0000565)1.89671426
137True hermaphroditism (HP:0010459)1.89641902
138Sleep apnea (HP:0010535)1.89597210
139Cerebral inclusion bodies (HP:0100314)1.89273571
140Hypochromic microcytic anemia (HP:0004840)1.89014769
141Pancreatic fibrosis (HP:0100732)1.88939190
142Pulmonary infiltrates (HP:0002113)1.88697575
143Eosinophilia (HP:0001880)1.88689244
144Aplasia/Hypoplasia of the lens (HP:0008063)1.88191291
145Dysmetria (HP:0001310)1.85883485
146Type I transferrin isoform profile (HP:0003642)1.85739265
147Inability to walk (HP:0002540)1.84793930
148Neonatal hypoglycemia (HP:0001998)1.83093470
149Abnormality of eosinophils (HP:0001879)1.82599060
150Acute necrotizing encephalopathy (HP:0006965)1.81782360
151Neurofibrillary tangles (HP:0002185)1.81302606
152Optic nerve hypoplasia (HP:0000609)1.81009804
153Impaired vibratory sensation (HP:0002495)1.80083172
154Hip dysplasia (HP:0001385)1.78824326
155Verrucae (HP:0200043)1.78573517
156Papilloma (HP:0012740)1.78573517
157Abnormality of the fovea (HP:0000493)1.78365638
158Osteomyelitis (HP:0002754)1.77809042
159Abnormality of saccadic eye movements (HP:0000570)1.77779153
160Abnormality of pain sensation (HP:0010832)1.77459932
161Impaired pain sensation (HP:0007328)1.77459932
162Abnormal mitochondria in muscle tissue (HP:0008316)1.77436811
163Dysmetric saccades (HP:0000641)1.76921917
164Iris hypopigmentation (HP:0007730)1.76865671
165Abnormality of binocular vision (HP:0011514)1.76649249
166Diplopia (HP:0000651)1.76649249
167Increased IgM level (HP:0003496)1.76311007
168Bradykinesia (HP:0002067)1.76064678
169Menstrual irregularities (HP:0000858)1.75328297
170Absent eyebrow (HP:0002223)1.75318649
171Decreased circulating renin level (HP:0003351)1.74127412
172Poor eye contact (HP:0000817)1.71838241
173Progressive macrocephaly (HP:0004481)1.70778391
174Thyroid-stimulating hormone excess (HP:0002925)1.69251162
175Chronic hepatic failure (HP:0100626)1.69113795
176Supranuclear gaze palsy (HP:0000605)1.65819944
177Spastic gait (HP:0002064)1.65577475
178Abnormality of ocular smooth pursuit (HP:0000617)1.64121526
179Generalized myoclonic seizures (HP:0002123)1.62027627
180Dysautonomia (HP:0002459)1.61028505
181Nonprogressive disorder (HP:0003680)1.59420088
182Hyperthyroidism (HP:0000836)1.58521266

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK6.08679942
2PRPF4B4.27410750
3NTRK33.28511746
4MAP2K73.23537726
5MAP4K13.03264680
6MAP3K123.03151951
7AKT32.88742763
8SIK32.41909111
9MAP3K42.39100392
10SGK22.24967431
11MAP3K132.19368650
12BLK2.11768451
13CDK192.09013827
14TYK22.05975847
15MAPK132.00205675
16DAPK21.97646305
17TNIK1.92666919
18SIK21.92612886
19EPHA41.86458434
20INSRR1.82867059
21SGK2231.81115961
22SGK4941.81115961
23MINK11.79492954
24JAK11.78355755
25BMPR21.76794993
26TAOK31.69586323
27MAP3K101.68115027
28CAMKK21.68041470
29CSK1.65685815
30PLK21.64963330
31DAPK11.61950847
32ZAP701.61893139
33MAP2K31.58201829
34PRKD31.51946625
35GRK61.50608061
36SYK1.48722876
37BTK1.46673020
38ITK1.44065246
39MARK11.42355612
40SGK31.42016108
41KSR21.39601349
42HCK1.38146784
43JAK31.36993803
44CDK121.36923519
45MAP2K41.36580129
46FGFR31.30796704
47RIPK41.27786473
48FGR1.17562313
49OXSR11.16974169
50TRIB31.16543072
51MAPK121.15543052
52JAK21.12847965
53ERBB31.12793151
54LCK1.10884597
55IKBKE1.08872234
56PRKCG1.06383729
57TYRO31.05855315
58BMPR1B1.04943530
59STK111.03322542
60FGFR41.02646486
61ADRBK21.00785508
62MUSK0.99860513
63CCNB10.98764927
64NTRK20.97188924
65YES10.97171541
66GRK50.96454315
67MAP3K140.96159313
68CAMKK10.95902272
69RET0.95463339
70CDK50.94325181
71BRAF0.94029294
72LYN0.86446238
73PRKCE0.85816085
74PRKCH0.85774466
75BCR0.84773215
76BRD40.84519501
77MAP3K70.83415246
78FES0.82534327
79CAMK2A0.81964466
80NEK60.81940187
81MAP3K90.81733195
82MARK30.80340980
83TEC0.79474765
84TNK20.79318432
85RPS6KA20.79264397
86TSSK60.78821015
87ARAF0.78123989
88CAMK1D0.77232194
89GRK70.76847765
90MAPK70.76212689
91CSF1R0.73081116
92UHMK10.72990284
93NLK0.72353961
94PDPK10.72165512
95FYN0.72031923
96CAMK2B0.71154361
97RIPK10.68283741
98KSR10.68170701
99MAP3K20.67950674
100MAP3K60.67567822
101SGK10.67175137
102CAMK1G0.66380354
103PRKCQ0.63957931
104EPHB10.63924420
105PINK10.63085995
106FGFR20.61438820
107TXK0.61344664
108FRK0.61220701
109CDC42BPA0.60199989
110TAOK10.59556756
111MKNK20.59384348
112RAF10.57848136
113CDK30.55360779
114NTRK10.55163299
115PDGFRB0.54478107
116DYRK1A0.54289183
117CDK80.53323652
118KIT0.53259302
119ICK0.52514636
120WNK30.52007942
121PIM10.51980758
122RPS6KB10.51848712
123NME10.51074152
124STK100.50887456
125MELK0.50618350
126IRAK40.50421984
127PAK60.49919466
128PKN20.47886533
129ADRBK10.45269784
130CDK180.44811869
131CAMK2D0.44688889
132CDK60.44686229
133HIPK20.42106227
134CAMK10.41959192
135MAP3K10.41934153
136WNK10.40118260
137IRAK30.39267827
138CAMK40.37662074
139PTK2B0.35398390
140MYLK0.34210009
141PRKACA0.33669333
142IRAK10.32827301
143FER0.32120559
144CDK140.32017862
145IRAK20.31715981
146STK160.31387954
147CDK150.30851341
148CSNK1A10.30235347
149PHKG20.30218720
150PHKG10.30218720
151PRKG10.29675611
152CAMK2G0.28303178
153PDK10.27906306
154MARK20.27617937
155RPS6KA30.25118884
156STK380.25029203
157PRKCA0.24513880

Predicted pathways (KEGG)

RankGene SetZ-score
1Synaptic vesicle cycle_Homo sapiens_hsa047214.10352559
2Nicotine addiction_Homo sapiens_hsa050333.54044863
3Collecting duct acid secretion_Homo sapiens_hsa049663.24833380
4Olfactory transduction_Homo sapiens_hsa047402.85563927
5Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.64128428
6Morphine addiction_Homo sapiens_hsa050322.58285849
7Circadian entrainment_Homo sapiens_hsa047132.56772870
8Insulin secretion_Homo sapiens_hsa049112.50372450
9GABAergic synapse_Homo sapiens_hsa047272.42294810
10Vibrio cholerae infection_Homo sapiens_hsa051102.41644690
11Taste transduction_Homo sapiens_hsa047422.30373363
12Amphetamine addiction_Homo sapiens_hsa050312.27255868
13Long-term potentiation_Homo sapiens_hsa047202.24466509
14Glutamatergic synapse_Homo sapiens_hsa047242.21460170
15B cell receptor signaling pathway_Homo sapiens_hsa046622.12233248
16Dopaminergic synapse_Homo sapiens_hsa047282.02954582
17T cell receptor signaling pathway_Homo sapiens_hsa046601.94071910
18Serotonergic synapse_Homo sapiens_hsa047261.89652530
19Osteoclast differentiation_Homo sapiens_hsa043801.87440973
20Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.78983855
21Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.73528294
22Cholinergic synapse_Homo sapiens_hsa047251.71437982
23Non-small cell lung cancer_Homo sapiens_hsa052231.68310554
24Primary immunodeficiency_Homo sapiens_hsa053401.66304168
25SNARE interactions in vesicular transport_Homo sapiens_hsa041301.64622049
26Maturity onset diabetes of the young_Homo sapiens_hsa049501.62804073
27Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.60917696
28Leishmaniasis_Homo sapiens_hsa051401.60433260
29Acute myeloid leukemia_Homo sapiens_hsa052211.60247090
30Salivary secretion_Homo sapiens_hsa049701.59933591
31Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.56098350
32Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.54502358
33Cocaine addiction_Homo sapiens_hsa050301.52961007
34Graft-versus-host disease_Homo sapiens_hsa053321.47632754
35Aldosterone synthesis and secretion_Homo sapiens_hsa049251.46923243
36Long-term depression_Homo sapiens_hsa047301.45815025
37Protein export_Homo sapiens_hsa030601.45367536
38Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.43769881
39Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.41306876
40Type I diabetes mellitus_Homo sapiens_hsa049401.39729396
41Renin secretion_Homo sapiens_hsa049241.38035157
42Calcium signaling pathway_Homo sapiens_hsa040201.37380446
43Measles_Homo sapiens_hsa051621.35432771
44Rheumatoid arthritis_Homo sapiens_hsa053231.35295941
45Allograft rejection_Homo sapiens_hsa053301.34089578
46VEGF signaling pathway_Homo sapiens_hsa043701.33484294
47Toll-like receptor signaling pathway_Homo sapiens_hsa046201.32272765
48Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.28972695
49Type II diabetes mellitus_Homo sapiens_hsa049301.28423841
50Autoimmune thyroid disease_Homo sapiens_hsa053201.24942798
51Gastric acid secretion_Homo sapiens_hsa049711.22000258
52Chronic myeloid leukemia_Homo sapiens_hsa052201.21061423
53Phototransduction_Homo sapiens_hsa047441.20792547
54Renal cell carcinoma_Homo sapiens_hsa052111.19116550
55Pancreatic cancer_Homo sapiens_hsa052121.14986781
56Platelet activation_Homo sapiens_hsa046111.12653226
57Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.12223891
58Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.10854554
59mTOR signaling pathway_Homo sapiens_hsa041501.09743473
60Colorectal cancer_Homo sapiens_hsa052101.08145460
61Phagosome_Homo sapiens_hsa041451.07982603
62cAMP signaling pathway_Homo sapiens_hsa040241.06317397
63Oxytocin signaling pathway_Homo sapiens_hsa049211.05070519
64Oxidative phosphorylation_Homo sapiens_hsa001901.04872964
65* Phosphatidylinositol signaling system_Homo sapiens_hsa040701.03984949
66Hepatitis B_Homo sapiens_hsa051611.03069424
67NOD-like receptor signaling pathway_Homo sapiens_hsa046211.02669037
68NF-kappa B signaling pathway_Homo sapiens_hsa040641.02266573
69Jak-STAT signaling pathway_Homo sapiens_hsa046300.99733392
70Toxoplasmosis_Homo sapiens_hsa051450.98231051
71Staphylococcus aureus infection_Homo sapiens_hsa051500.97125144
72Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.95241120
73Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.93741019
74Leukocyte transendothelial migration_Homo sapiens_hsa046700.92925549
75Influenza A_Homo sapiens_hsa051640.92862590
76FoxO signaling pathway_Homo sapiens_hsa040680.92776128
77RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.90436063
78AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.89773700
79Viral myocarditis_Homo sapiens_hsa054160.88929830
80GnRH signaling pathway_Homo sapiens_hsa049120.88752884
81Regulation of autophagy_Homo sapiens_hsa041400.88139054
82Thyroid hormone signaling pathway_Homo sapiens_hsa049190.88027052
83Circadian rhythm_Homo sapiens_hsa047100.84432256
84Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.83221884
85ErbB signaling pathway_Homo sapiens_hsa040120.81004809
86Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.80354306
87TNF signaling pathway_Homo sapiens_hsa046680.80046675
88Gap junction_Homo sapiens_hsa045400.78451133
89Malaria_Homo sapiens_hsa051440.77552972
90Intestinal immune network for IgA production_Homo sapiens_hsa046720.77515671
91Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.77146870
92Antigen processing and presentation_Homo sapiens_hsa046120.76085838
93Hepatitis C_Homo sapiens_hsa051600.75765479
94Vascular smooth muscle contraction_Homo sapiens_hsa042700.75271397
95Hematopoietic cell lineage_Homo sapiens_hsa046400.74179127
96Longevity regulating pathway - mammal_Homo sapiens_hsa042110.73372085
97Herpes simplex infection_Homo sapiens_hsa051680.73258833
98Apoptosis_Homo sapiens_hsa042100.71506537
99cGMP-PKG signaling pathway_Homo sapiens_hsa040220.71384866
100Axon guidance_Homo sapiens_hsa043600.70159703
101African trypanosomiasis_Homo sapiens_hsa051430.68278932
102Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.67924782
103Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.66106714
104Alzheimers disease_Homo sapiens_hsa050100.65898360
105MAPK signaling pathway_Homo sapiens_hsa040100.62416449
106HIF-1 signaling pathway_Homo sapiens_hsa040660.61650620
107Prostate cancer_Homo sapiens_hsa052150.61184836
108Pancreatic secretion_Homo sapiens_hsa049720.61015440
109Melanogenesis_Homo sapiens_hsa049160.60814356
110Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.58269568
111Estrogen signaling pathway_Homo sapiens_hsa049150.57492391
112Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.56725012
113Thyroid hormone synthesis_Homo sapiens_hsa049180.55519820
114Carbohydrate digestion and absorption_Homo sapiens_hsa049730.54322378
115Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.53852366
116Neurotrophin signaling pathway_Homo sapiens_hsa047220.52451930
117Sphingolipid metabolism_Homo sapiens_hsa006000.52146566
118Ras signaling pathway_Homo sapiens_hsa040140.51216600
119Chemokine signaling pathway_Homo sapiens_hsa040620.48084271
120Sulfur metabolism_Homo sapiens_hsa009200.47985887
121Glucagon signaling pathway_Homo sapiens_hsa049220.46412862
122Glioma_Homo sapiens_hsa052140.44533855
123N-Glycan biosynthesis_Homo sapiens_hsa005100.44068173
124Prolactin signaling pathway_Homo sapiens_hsa049170.43175419
125Parkinsons disease_Homo sapiens_hsa050120.41583500
126Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.39905254
127Lysosome_Homo sapiens_hsa041420.37998024
128* Inositol phosphate metabolism_Homo sapiens_hsa005620.37875132
129Ovarian steroidogenesis_Homo sapiens_hsa049130.36784890
130Alcoholism_Homo sapiens_hsa050340.35130113
131Endometrial cancer_Homo sapiens_hsa052130.30800659
132Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.30441549
133Huntingtons disease_Homo sapiens_hsa050160.28065839
134Dorso-ventral axis formation_Homo sapiens_hsa043200.27559408
135Prion diseases_Homo sapiens_hsa050200.27455414
136Insulin signaling pathway_Homo sapiens_hsa049100.27243631
137Tuberculosis_Homo sapiens_hsa051520.26014875
138Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.25524786
139Cardiac muscle contraction_Homo sapiens_hsa042600.24373306
140Phospholipase D signaling pathway_Homo sapiens_hsa040720.24305148
141Other glycan degradation_Homo sapiens_hsa005110.24110077
142Choline metabolism in cancer_Homo sapiens_hsa052310.22423136
143Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.22145268
144Endocytosis_Homo sapiens_hsa041440.21216311
145Sphingolipid signaling pathway_Homo sapiens_hsa040710.21141687
146Dilated cardiomyopathy_Homo sapiens_hsa054140.19220951
147Melanoma_Homo sapiens_hsa052180.19170518
148Oocyte meiosis_Homo sapiens_hsa041140.19131185
149Rap1 signaling pathway_Homo sapiens_hsa040150.16904918

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