INPP4B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: INPP4B encodes the inositol polyphosphate 4-phosphatase type II, one of the enzymes involved in phosphatidylinositol signaling pathways. This enzyme removes the phosphate group at position 4 of the inositol ring from inositol 3,4-bisphosphate. There is limited data to suggest that the human type II enzyme is subject to alternative splicing, as has been established for the type I enzyme. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative T cell selection (GO:0043383)8.25935064
2negative thymic T cell selection (GO:0045060)7.98561537
3positive regulation of gamma-delta T cell activation (GO:0046645)7.74174576
4negative regulation of cell killing (GO:0031342)7.66863723
5negative regulation of leukocyte mediated cytotoxicity (GO:0001911)7.66863723
6regulation of isotype switching to IgG isotypes (GO:0048302)7.29053258
7positive thymic T cell selection (GO:0045059)7.03268427
8positive T cell selection (GO:0043368)6.79542975
9thymic T cell selection (GO:0045061)6.70459996
10regulation of T cell tolerance induction (GO:0002664)6.50644179
11T cell selection (GO:0045058)6.41643010
12regulation of gamma-delta T cell differentiation (GO:0045586)6.33463372
13tolerance induction (GO:0002507)6.28811839
14positive regulation of interleukin-2 biosynthetic process (GO:0045086)6.27695634
15response to interleukin-15 (GO:0070672)6.25887099
16antigen processing and presentation of endogenous peptide antigen (GO:0002483)6.09766778
17antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)6.09766778
18positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)5.94553231
19cellular response to interleukin-15 (GO:0071350)5.86123805
20regulation of gamma-delta T cell activation (GO:0046643)5.84002004
21interferon-gamma production (GO:0032609)5.65183597
22hepatocyte apoptotic process (GO:0097284)5.51469766
23positive regulation of tolerance induction (GO:0002645)5.22742096
24antigen processing and presentation of endogenous antigen (GO:0019883)5.16019735
25leukocyte aggregation (GO:0070486)5.11013811
26T cell costimulation (GO:0031295)5.09409800
27T cell receptor signaling pathway (GO:0050852)5.07698025
28lymphocyte costimulation (GO:0031294)5.05054402
29T cell migration (GO:0072678)5.03416374
30regulation of regulatory T cell differentiation (GO:0045589)4.91655129
31regulation of interleukin-2 biosynthetic process (GO:0045076)4.91239202
32membrane raft organization (GO:0031579)4.80573497
33negative regulation of T cell mediated immunity (GO:0002710)4.66340497
34hemidesmosome assembly (GO:0031581)4.64730768
35regulation of alpha-beta T cell proliferation (GO:0046640)4.64416202
36regulation of B cell receptor signaling pathway (GO:0050855)4.62335604
37regulation of tolerance induction (GO:0002643)4.59688479
38regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)4.55543111
39antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.55028959
40positive regulation of isotype switching (GO:0045830)4.36038785
41regulation of isotype switching (GO:0045191)4.28520454
42antigen receptor-mediated signaling pathway (GO:0050851)4.27869959
43positive regulation of interleukin-2 production (GO:0032743)4.18930659
44regulation of interleukin-12 biosynthetic process (GO:0045075)4.16887683
45melanin metabolic process (GO:0006582)4.13834655
46positive regulation of alpha-beta T cell proliferation (GO:0046641)4.10104667
47regulation of antigen receptor-mediated signaling pathway (GO:0050854)4.08907747
48striated muscle atrophy (GO:0014891)4.05428759
49melanin biosynthetic process (GO:0042438)4.01694642
50positive regulation of natural killer cell mediated immunity (GO:0002717)4.00293685
51positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)4.00293685
52tyrosine phosphorylation of STAT protein (GO:0007260)3.99014795
53regulation of T cell receptor signaling pathway (GO:0050856)3.98571659
54positive regulation of B cell mediated immunity (GO:0002714)3.95383764
55positive regulation of immunoglobulin mediated immune response (GO:0002891)3.95383764
56regulation of natural killer cell mediated immunity (GO:0002715)3.92640657
57regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.92640657
58activated T cell proliferation (GO:0050798)3.89491248
59regulation of immunoglobulin mediated immune response (GO:0002889)3.87779441
60regulation of B cell mediated immunity (GO:0002712)3.77119006
61positive regulation of DNA recombination (GO:0045911)3.73822305
62positive regulation of humoral immune response (GO:0002922)3.72831008
63negative regulation of lymphocyte mediated immunity (GO:0002707)3.71660224
64regulation of immunoglobulin production (GO:0002637)3.60732360
65JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)3.51689792
66alpha-beta T cell differentiation (GO:0046632)3.49787155
67skeletal muscle adaptation (GO:0043501)3.49565121
68alpha-beta T cell activation (GO:0046631)3.48936489
69T cell differentiation (GO:0030217)3.44846049
70desmosome organization (GO:0002934)3.43842140
71mast cell activation (GO:0045576)3.41090106
72positive regulation of immunoglobulin production (GO:0002639)3.40889820
73positive regulation of natural killer cell differentiation (GO:0032825)3.37492350
74negative regulation of adaptive immune response based on somatic recombination of immune receptors b3.35248742
75muscle atrophy (GO:0014889)3.33260125
76regulation of response to interferon-gamma (GO:0060330)3.31793731
77regulation of interleukin-2 production (GO:0032663)3.29166470
78regulation of interferon-gamma-mediated signaling pathway (GO:0060334)3.29163896
79regulation of B cell differentiation (GO:0045577)3.25897795
80positive regulation of leukocyte mediated cytotoxicity (GO:0001912)3.25818871
81T cell homeostasis (GO:0043029)3.25385231
82positive regulation of inflammatory response to antigenic stimulus (GO:0002863)3.25074527
83regulation of leukocyte mediated cytotoxicity (GO:0001910)3.21831757
84regulation of calcineurin-NFAT signaling cascade (GO:0070884)3.17092323
85secondary metabolite biosynthetic process (GO:0044550)3.16612657
86actin-myosin filament sliding (GO:0033275)3.14779385
87muscle filament sliding (GO:0030049)3.14779385
88positive regulation of keratinocyte differentiation (GO:0045618)3.14718437
89negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)3.13348178
90leukocyte cell-cell adhesion (GO:0007159)3.11826034
91CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)3.11697600
92keratinocyte development (GO:0003334)3.11057049
93regulation of cell killing (GO:0031341)3.10502334
94regulation of defense response to virus by virus (GO:0050690)3.09803366
95negative regulation of T cell receptor signaling pathway (GO:0050860)3.08181213
96response to stimulus involved in regulation of muscle adaptation (GO:0014874)3.07606674
97T cell activation (GO:0042110)3.07192423
98melanocyte differentiation (GO:0030318)3.05841540
99T cell proliferation (GO:0042098)3.03533979
100regulation of T cell mediated cytotoxicity (GO:0001914)3.01860333
101sarcomere organization (GO:0045214)3.00924906
102antigen processing and presentation via MHC class Ib (GO:0002475)2.99959816
103positive regulation of T cell activation (GO:0050870)2.99519595
104natural killer cell activation (GO:0030101)2.98811134
105actin-mediated cell contraction (GO:0070252)2.98690410
106positive regulation of cell killing (GO:0031343)2.96640368
107negative regulation of adaptive immune response (GO:0002820)2.95007556
108positive regulation of granulocyte differentiation (GO:0030854)2.94826514
109immune response-activating cell surface receptor signaling pathway (GO:0002429)2.94805649
110regulation of lymphocyte mediated immunity (GO:0002706)2.94328193
111positive regulation of lymphocyte mediated immunity (GO:0002708)2.94042150
112T-helper cell differentiation (GO:0042093)2.93720006
113CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)2.93720006
114regulation of alpha-beta T cell activation (GO:0046634)2.93544477
115B cell receptor signaling pathway (GO:0050853)2.93076075
116lymphocyte homeostasis (GO:0002260)2.91179415
117growth hormone receptor signaling pathway (GO:0060396)2.89753594
118pigment cell differentiation (GO:0050931)2.89697353
119positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.89189408
120regulation of alkaline phosphatase activity (GO:0010692)2.88922667
121positive regulation of T cell mediated cytotoxicity (GO:0001916)2.87467957
122heterotypic cell-cell adhesion (GO:0034113)2.86926103
123positive regulation of B cell proliferation (GO:0030890)2.86657064
124lymph node development (GO:0048535)2.84867796
125regulation of type I interferon-mediated signaling pathway (GO:0060338)2.84053238
126positive regulation of interleukin-4 production (GO:0032753)2.84005406
127regulation of establishment of cell polarity (GO:2000114)2.81986759
128T cell differentiation involved in immune response (GO:0002292)2.78010163
129alpha-beta T cell differentiation involved in immune response (GO:0002293)2.78010163
130alpha-beta T cell activation involved in immune response (GO:0002287)2.78010163
131hypotonic response (GO:0006971)2.76802691
132negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.74707854
133CD4-positive, alpha-beta T cell differentiation (GO:0043367)2.64381624
134positive regulation of natural killer cell activation (GO:0032816)2.62932857
135actin filament-based movement (GO:0030048)2.62590711
136regulation of transforming growth factor beta2 production (GO:0032909)2.61379289
137necroptotic process (GO:0070266)2.59108926
138negative regulation of nitric-oxide synthase activity (GO:0051001)2.56202597
139negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.55635044
140negative regulation of T-helper cell differentiation (GO:0045623)2.55635044
141pericardium development (GO:0060039)2.52549579
142plasma membrane repair (GO:0001778)2.51339517
143regulation of relaxation of muscle (GO:1901077)2.50393590
144CD4-positive, alpha-beta T cell activation (GO:0035710)2.49679163
145G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)2.48862575
146response to inactivity (GO:0014854)2.48479664
147negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.46920480
148actomyosin structure organization (GO:0031032)2.46879046
149regulation of keratinocyte differentiation (GO:0045616)2.46546688
150bundle of His cell to Purkinje myocyte communication (GO:0086069)2.45721991
151cell-substrate junction assembly (GO:0007044)2.45413741
152cellular response to growth hormone stimulus (GO:0071378)2.44725574
153fibroblast migration (GO:0010761)2.44100945
154regulation of necroptotic process (GO:0060544)2.42456106
155negative regulation of stress fiber assembly (GO:0051497)2.42043133
156negative regulation of monooxygenase activity (GO:0032769)2.38268343
157establishment of protein localization to Golgi (GO:0072600)2.36989035

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse9.91019167
2STAT6_20620947_ChIP-Seq_CD4_POS_T_Human7.34444170
3RUNX_20019798_ChIP-Seq_JUKART_Human4.46213732
4* STAT3_20064451_ChIP-Seq_CD4+T_Mouse4.36055226
5IRF8_22096565_ChIP-ChIP_GC-B_Human3.88738865
6* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse3.77257907
7IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.59885588
8STAT4_19710469_ChIP-ChIP_TH1__Mouse3.51372287
9IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.44058531
10BP1_19119308_ChIP-ChIP_Hs578T_Human3.40777082
11MYB_26560356_Chip-Seq_TH2_Human3.27774654
12ESR1_20079471_ChIP-ChIP_T-47D_Human3.26935985
13TP63_17297297_ChIP-ChIP_HaCaT_Human3.26832856
14MYC_22102868_ChIP-Seq_BL_Human3.17383338
15NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.07194572
16MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.01731424
17MAF_26560356_Chip-Seq_TH1_Human2.96391207
18MYB_26560356_Chip-Seq_TH1_Human2.71043583
19UTX_26944678_Chip-Seq_JUKART_Human2.68287088
20* ZNF217_24962896_ChIP-Seq_MCF-7_Human2.27044924
21NOTCH1_21737748_ChIP-Seq_TLL_Human2.26031506
22GATA2_21666600_ChIP-Seq_HMVEC_Human2.22038416
23GATA3_27048872_Chip-Seq_THYMUS_Human2.20240493
24SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.15159632
25TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.14108540
26KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.11603380
27RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.05884748
28VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.05799028
29EGR1_19374776_ChIP-ChIP_THP-1_Human2.05134409
30SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.04641846
31SCL_19346495_ChIP-Seq_HPC-7_Human2.04538362
32TCF7_22412390_ChIP-Seq_EML_Mouse2.04179793
33VDR_21846776_ChIP-Seq_THP-1_Human2.02531668
34SMAD_19615063_ChIP-ChIP_OVARY_Human2.02269783
35MAF_26560356_Chip-Seq_TH2_Human1.99271914
36SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.97288057
37SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.94811644
38SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.94811644
39NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.88479790
40CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.86643089
41IRF8_21731497_ChIP-ChIP_J774_Mouse1.85768407
42RUNX1_22412390_ChIP-Seq_EML_Mouse1.81348626
43IRF8_27001747_Chip-Seq_BMDM_Mouse1.80941581
44KDM2B_26808549_Chip-Seq_DND41_Human1.78765985
45E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.78027757
46KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.70657032
47CJUN_26792858_Chip-Seq_BT549_Human1.68713640
48AHR_22903824_ChIP-Seq_MCF-7_Human1.67382274
49FLI1_27457419_Chip-Seq_LIVER_Mouse1.66969119
50RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.64059842
51BRD4_25478319_ChIP-Seq_HGPS_Human1.62469698
52Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.62321997
53* FOXM1_26456572_ChIP-Seq_MCF-7_Human1.62026282
54SPI1_23127762_ChIP-Seq_K562_Human1.62014183
55* PPAR_26484153_Chip-Seq_NCI-H1993_Human1.60585757
56MYB_21317192_ChIP-Seq_ERMYB_Mouse1.59373517
57ESR1_21235772_ChIP-Seq_MCF-7_Human1.54526626
58SPI1_23547873_ChIP-Seq_NB4_Human1.54418462
59SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.53950795
60ARNT_22903824_ChIP-Seq_MCF-7_Human1.53124952
61BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.52977106
62* VDR_24763502_ChIP-Seq_THP-1_Human1.51331814
63KDM2B_26808549_Chip-Seq_SUP-B15_Human1.51167647
64FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.44633980
65PCGF2_27294783_Chip-Seq_ESCs_Mouse1.41951615
66ER_23166858_ChIP-Seq_MCF-7_Human1.41890354
67ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.41275357
68CDX2_19796622_ChIP-Seq_MESCs_Mouse1.40338007
69KDM2B_26808549_Chip-Seq_JURKAT_Human1.39863037
70BRD4_27068464_Chip-Seq_AML-cells_Mouse1.39848932
71PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.39786853
72GATA3_26560356_Chip-Seq_TH2_Human1.38971075
73TP63_23658742_ChIP-Seq_EP156T_Human1.38165213
74AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.35888205
75PU_27001747_Chip-Seq_BMDM_Mouse1.32269374
76SALL1_21062744_ChIP-ChIP_HESCs_Human1.29878685
77MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.28978563
78PCGF2_27294783_Chip-Seq_NPCs_Mouse1.27852532
79* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.27806977
80JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.27425371
81CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.27004870
82SUZ12_27294783_Chip-Seq_NPCs_Mouse1.25817610
83EZH2_27294783_Chip-Seq_NPCs_Mouse1.25127405
84NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.24631868
85NRF2_20460467_ChIP-Seq_MEFs_Mouse1.24631868
86EP300_21415370_ChIP-Seq_HL-1_Mouse1.23813327
87RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.23419089
88* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.23274022
89CIITA_25753668_ChIP-Seq_RAJI_Human1.23219810
90AR_21572438_ChIP-Seq_LNCaP_Human1.21925645
91ESR2_21235772_ChIP-Seq_MCF-7_Human1.20818642
92SOX9_24532713_ChIP-Seq_HFSC_Mouse1.19763690
93NFE2_27457419_Chip-Seq_LIVER_Mouse1.18896605
94CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.16238019
95JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.15804180
96GATA2_22383799_ChIP-Seq_G1ME_Mouse1.14800295
97ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.12368741
98E2F7_22180533_ChIP-Seq_HELA_Human1.10896152
99* ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.10472853
100ELF1_17652178_ChIP-ChIP_JURKAT_Human1.09863479
101* CTNNB1_20460455_ChIP-Seq_HCT116_Human1.08761485
102TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.07728305
103GATA3_24758297_ChIP-Seq_MCF-7_Human1.06564475
104FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.05373025
105CRX_20693478_ChIP-Seq_RETINA_Mouse1.02095910
106PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.01709617
107* RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.01272488
108* SOX2_20726797_ChIP-Seq_SW620_Human1.01215065
109E2F1_18555785_Chip-Seq_ESCs_Mouse1.00040017
110TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.98576022
111PIAS1_25552417_ChIP-Seq_VCAP_Human0.98548847
112P53_22387025_ChIP-Seq_ESCs_Mouse0.98484047
113TP53_16413492_ChIP-PET_HCT116_Human0.96046145
114OCT4_18555785_Chip-Seq_ESCs_Mouse0.94198214
115CDX2_22108803_ChIP-Seq_LS180_Human0.93964359
116* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.93806831
117TP53_18474530_ChIP-ChIP_U2OS_Human0.92311015
118* NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.92121654
119TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.92011423
120GATA1_19941827_ChIP-Seq_MEL_Mouse0.91974757
121NANOG_18555785_Chip-Seq_ESCs_Mouse0.91895361
122OCT4_21477851_ChIP-Seq_ESCs_Mouse0.91837285
123LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.91736950
124ELK3_25401928_ChIP-Seq_HUVEC_Human0.90689146
125SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.90294455
126* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.90180769
127TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.89608303
128SOX2_18555785_Chip-Seq_ESCs_Mouse0.88674616
129P63_26484246_Chip-Seq_KERATINOCYTES_Human0.88218117
130* SMAD4_21799915_ChIP-Seq_A2780_Human0.87437025
131SUZ12_18555785_Chip-Seq_ESCs_Mouse0.87075889
132STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.86516758
133GATA1_22025678_ChIP-Seq_K562_Human0.85684439
134FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.84133410
135VDR_24787735_ChIP-Seq_THP-1_Human0.82419144
136* CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.82104859
137DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.81001049
138GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.79710359
139* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.79472154
140* CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.79062315
141SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.78728944
142CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.76528711
143GATA1_19941826_ChIP-Seq_K562_Human0.74618819
144PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.74542697
145* RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.74065515
146SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human0.73407295
147GATA2_19941826_ChIP-Seq_K562_Human0.73020533
148THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.72946531
149FOXO3_23340844_ChIP-Seq_DLD1_Human0.71966326
150NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.71285995
151LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.69204329
152PU.1_20513432_ChIP-Seq_Bcells_Mouse0.67941243
153SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.65986048
154GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.65946519
155GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.64304899
156TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.62891849
157NCOR1_26117541_ChIP-Seq_K562_Human0.62072371
158CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.61947211
159GATA1_22383799_ChIP-Seq_G1ME_Mouse0.59983572
160RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.56803591
161TBX20_22328084_ChIP-Seq_HEART_Mouse0.55720517
162TBX20_22080862_ChIP-Seq_HEART_Mouse0.55720517
163EGR1_19032775_ChIP-ChIP_M12_Human0.55454174
164GATA3_26560356_Chip-Seq_TH1_Human0.55071310
165KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.53629332
166* PRDM14_20953172_ChIP-Seq_ESCs_Human0.53021639

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003763_abnormal_thymus_physiology5.79760959
2MP0005671_abnormal_response_to4.64959348
3MP0000372_irregular_coat_pigmentation3.99597499
4MP0000569_abnormal_digit_pigmentation3.79570100
5MP0003950_abnormal_plasma_membrane3.43661377
6MP0003300_gastrointestinal_ulcer3.33769656
7MP0000685_abnormal_immune_system3.27149510
8MP0005171_absent_coat_pigmentation3.23465229
9MP0002166_altered_tumor_susceptibility3.20546431
10MP0001800_abnormal_humoral_immune3.10238314
11MP0000015_abnormal_ear_pigmentation3.09097797
12MP0005408_hypopigmentation3.08819281
13MP0001835_abnormal_antigen_presentation3.06413724
14MP0001790_abnormal_immune_system3.00188673
15MP0005387_immune_system_phenotype3.00188673
16MP0009333_abnormal_splenocyte_physiolog2.91327896
17MP0005000_abnormal_immune_tolerance2.87231477
18MP0002420_abnormal_adaptive_immunity2.69988898
19MP0002398_abnormal_bone_marrow2.67782051
20MP0001819_abnormal_immune_cell2.65665220
21MP0002723_abnormal_immune_serum2.65591367
22MP0001873_stomach_inflammation2.61298353
23MP0003436_decreased_susceptibility_to2.56126253
24MP0000703_abnormal_thymus_morphology2.52878548
25MP0002405_respiratory_system_inflammati2.50435138
26MP0002006_tumorigenesis2.49119628
27MP0003866_abnormal_defecation2.48553748
28MP0002452_abnormal_antigen_presenting2.44650665
29MP0000749_muscle_degeneration2.36137973
30MP0000716_abnormal_immune_system2.30460162
31MP0006082_CNS_inflammation2.26829052
32MP0002396_abnormal_hematopoietic_system2.24575536
33MP0002722_abnormal_immune_system2.18839580
34MP0010155_abnormal_intestine_physiology2.18542775
35MP0009785_altered_susceptibility_to2.18395516
36MP0004510_myositis2.17188080
37MP0005025_abnormal_response_to2.14206927
38MP0003724_increased_susceptibility_to2.11618798
39MP0000689_abnormal_spleen_morphology2.07884957
40MP0005174_abnormal_tail_pigmentation2.07749083
41MP0000465_gastrointestinal_hemorrhage2.02507427
42MP0003303_peritoneal_inflammation2.00312999
43MP0002009_preneoplasia2.00278610
44MP0010234_abnormal_vibrissa_follicle2.00254124
45MP0004947_skin_inflammation1.98972474
46MP0002933_joint_inflammation1.92980673
47MP0000371_diluted_coat_color1.85298532
48MP0002429_abnormal_blood_cell1.84844808
49MP0009780_abnormal_chondrocyte_physiolo1.84127365
50MP0002148_abnormal_hypersensitivity_rea1.81999907
51MP0001853_heart_inflammation1.74953587
52MP0000427_abnormal_hair_cycle1.70574427
53MP0004808_abnormal_hematopoietic_stem1.66177032
54MP0002095_abnormal_skin_pigmentation1.63200968
55MP0005464_abnormal_platelet_physiology1.63107804
56MP0002419_abnormal_innate_immunity1.63033375
57MP0001845_abnormal_inflammatory_respons1.57034784
58MP0006054_spinal_hemorrhage1.50727511
59MP0004381_abnormal_hair_follicle1.49661930
60MP0003045_fibrosis1.42565009
61MP0004484_altered_response_of1.40526444
62MP0010678_abnormal_skin_adnexa1.38715592
63MP0002060_abnormal_skin_morphology1.31941697
64MP0008961_abnormal_basal_metabolism1.31705824
65MP0001851_eye_inflammation1.29829305
66MP0004883_abnormal_blood_vessel1.27175681
67MP0005310_abnormal_salivary_gland1.24500819
68MP0003191_abnormal_cellular_cholesterol1.22577239
69MP0005275_abnormal_skin_tensile1.22368323
70MP0005409_darkened_coat_color1.21897953
71MP0003448_altered_tumor_morphology1.19201856
72MP0001348_abnormal_lacrimal_gland1.18331426
73MP0001533_abnormal_skeleton_physiology1.17490368
74MP0000858_altered_metastatic_potential1.10310698
75MP0002332_abnormal_exercise_endurance1.08535092
76MP0004233_abnormal_muscle_weight1.01744934
77MP0005164_abnormal_response_to1.00751462
78MP0000759_abnormal_skeletal_muscle1.00655505
79MP0000751_myopathy0.99800280
80MP0002075_abnormal_coat/hair_pigmentati0.97964019
81MP0008469_abnormal_protein_level0.94520235
82MP0005023_abnormal_wound_healing0.93755912
83MP0004264_abnormal_extraembryonic_tissu0.93617701
84MP0004087_abnormal_muscle_fiber0.92931520
85MP0002998_abnormal_bone_remodeling0.92898208
86MP0002269_muscular_atrophy0.92410714
87MP0005620_abnormal_muscle_contractility0.92229121
88MP0004084_abnormal_cardiac_muscle0.90441555
89MP0005075_abnormal_melanosome_morpholog0.89183724
90MP0001186_pigmentation_phenotype0.87822656
91MP0000377_abnormal_hair_follicle0.86448331
92MP0000490_abnormal_crypts_of0.85558417
93MP0001958_emphysema0.85410035
94MP0008438_abnormal_cutaneous_collagen0.84023690
95MP0002796_impaired_skin_barrier0.80467396
96MP0001542_abnormal_bone_strength0.80301935
97MP0000750_abnormal_muscle_regeneration0.79823109
98MP0001661_extended_life_span0.78678150
99MP0003646_muscle_fatigue0.78360616
100MP0002019_abnormal_tumor_incidence0.78200788
101MP0000013_abnormal_adipose_tissue0.78064623
102MP0001545_abnormal_hematopoietic_system0.76632343
103MP0005397_hematopoietic_system_phenotyp0.76632343
104MP0004134_abnormal_chest_morphology0.76607817
105MP0000627_abnormal_mammary_gland0.76228988
106MP0003136_yellow_coat_color0.76216312
107MP0001243_abnormal_dermal_layer0.75900838
108MP0002108_abnormal_muscle_morphology0.75433465
109MP0005076_abnormal_cell_differentiation0.73838675
110MP0010352_gastrointestinal_tract_polyps0.72221682
111MP0008569_lethality_at_weaning0.71776020
112MP0002972_abnormal_cardiac_muscle0.71533933
113MP0003172_abnormal_lysosome_physiology0.68848458
114MP0003787_abnormal_imprinting0.65996177
115MP0003828_pulmonary_edema0.64329230
116MP0009765_abnormal_xenobiotic_induced0.63819904
117MP0003795_abnormal_bone_structure0.62203781
118MP0003279_aneurysm0.60372676
119MP0009764_decreased_sensitivity_to0.59154326
120MP0000604_amyloidosis0.58564722
121MP0009763_increased_sensitivity_to0.58139530
122MP0000249_abnormal_blood_vessel0.57397898
123MP0003453_abnormal_keratinocyte_physiol0.56357125
124MP0003091_abnormal_cell_migration0.54815416
125MP0000733_abnormal_muscle_development0.52536510
126MP0003566_abnormal_cell_adhesion0.52526184
127MP0004185_abnormal_adipocyte_glucose0.52521525
128MP0001881_abnormal_mammary_gland0.51165258
129MP0001663_abnormal_digestive_system0.51036336
130MP0008775_abnormal_heart_ventricle0.50365834
131MP0002877_abnormal_melanocyte_morpholog0.48402096
132MP0008007_abnormal_cellular_replicative0.47366353
133MP0008057_abnormal_DNA_replication0.46918280
134MP0002822_catalepsy0.46668660
135MP0009384_cardiac_valve_regurgitation0.46533846
136MP0000343_altered_response_to0.46530766
137MP0000477_abnormal_intestine_morphology0.44802316
138MP0010630_abnormal_cardiac_muscle0.44286850
139MP0004130_abnormal_muscle_cell0.39983366
140MP0001216_abnormal_epidermal_layer0.39912346
141MP0001191_abnormal_skin_condition0.39850045
142MP0003183_abnormal_peptide_metabolism0.39554523
143MP0005390_skeleton_phenotype0.39348062
144MP0005165_increased_susceptibility_to0.38453506
145MP0002693_abnormal_pancreas_physiology0.38303547
146MP0000383_abnormal_hair_follicle0.37379843
147MP0000367_abnormal_coat/_hair0.34834911
148MP0004036_abnormal_muscle_relaxation0.34119140

Predicted human phenotypes

RankGene SetZ-score
1T lymphocytopenia (HP:0005403)7.36587035
2Abnormality of T cell number (HP:0011839)7.03020533
3Stomatitis (HP:0010280)5.27342080
4Recurrent bronchitis (HP:0002837)5.26462735
5Abnormality of T cells (HP:0002843)5.24011262
6Popliteal pterygium (HP:0009756)4.79206916
7Elevated erythrocyte sedimentation rate (HP:0003565)4.76053175
8IgM deficiency (HP:0002850)4.74030368
9Severe combined immunodeficiency (HP:0004430)4.72033639
10Recurrent fungal infections (HP:0002841)4.43656352
11Chronic diarrhea (HP:0002028)4.39366969
12Chronic otitis media (HP:0000389)4.29559883
13Combined immunodeficiency (HP:0005387)4.22486723
14Recurrent viral infections (HP:0004429)4.17267510
15Nemaline bodies (HP:0003798)4.12712815
16Myositis (HP:0100614)4.02884111
17IgG deficiency (HP:0004315)4.02355600
18Abnormality of the fingertips (HP:0001211)3.96125524
19Nasal polyposis (HP:0100582)3.88930141
20Recurrent cutaneous fungal infections (HP:0011370)3.88442575
21Chronic mucocutaneous candidiasis (HP:0002728)3.88442575
22Panhypogammaglobulinemia (HP:0003139)3.81769466
23Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)3.80038991
24Fatigable weakness (HP:0003473)3.71895638
25Abnormality of the neuromuscular junction (HP:0003398)3.71895638
26IgA deficiency (HP:0002720)3.65409507
27Type 2 muscle fiber atrophy (HP:0003554)3.64725508
28Autoimmune hemolytic anemia (HP:0001890)3.64004125
29Hyporeflexia of lower limbs (HP:0002600)3.62663481
30Muscle fiber inclusion bodies (HP:0100299)3.56531413
31Milia (HP:0001056)3.54573967
32Abnormal delayed hypersensitivity skin test (HP:0002963)3.53477779
33Abnormality of B cell number (HP:0010975)3.51076242
34B lymphocytopenia (HP:0010976)3.51076242
35Abnormality of eosinophils (HP:0001879)3.50885377
36Pustule (HP:0200039)3.42249929
37Abnormality of T cell physiology (HP:0011840)3.41666944
38Amniotic constriction ring (HP:0009775)3.41300263
39Abnormality of placental membranes (HP:0011409)3.41300263
40Eczematoid dermatitis (HP:0000976)3.41103726
41Lymphopenia (HP:0001888)3.36472560
42Abnormality of the nasal mucosa (HP:0000433)3.30740534
43Optic neuritis (HP:0100653)3.30422098
44Retrobulbar optic neuritis (HP:0100654)3.30422098
45Ocular albinism (HP:0001107)3.26853209
46Abnormality of the left ventricular outflow tract (HP:0011103)3.24229580
47Subaortic stenosis (HP:0001682)3.24229580
48Glucose intolerance (HP:0000833)3.21307237
49Abnormality of cells of the lymphoid lineage (HP:0012140)3.18957661
50Joint swelling (HP:0001386)3.18018833
51Weak cry (HP:0001612)3.17446782
52Inflammation of the large intestine (HP:0002037)3.09200754
53Eosinophilia (HP:0001880)3.06564044
54Muscle fiber atrophy (HP:0100295)3.05650204
55Increased IgM level (HP:0003496)3.01803677
56Leukocytosis (HP:0001974)2.99980184
57Blue irides (HP:0000635)2.99728700
58Hemoptysis (HP:0002105)2.97020645
59Gastrointestinal inflammation (HP:0004386)2.95757911
60Vasculitis (HP:0002633)2.95483291
61Calf muscle hypertrophy (HP:0008981)2.93716787
62Thyroiditis (HP:0100646)2.93613645
63Absent frontal sinuses (HP:0002688)2.91579426
64Muscle hypertrophy of the lower extremities (HP:0008968)2.90634246
65Bronchitis (HP:0012387)2.89874848
66Increased density of long bones (HP:0006392)2.86817779
67Pulmonary infiltrates (HP:0002113)2.84510094
68Orchitis (HP:0100796)2.78453175
69Sudden death (HP:0001699)2.78043728
70Aortic dissection (HP:0002647)2.77203724
71Neck muscle weakness (HP:0000467)2.74519553
72Recurrent sinusitis (HP:0011108)2.73356048
73Malignant hyperthermia (HP:0002047)2.69430076
74Atrophic scars (HP:0001075)2.68991719
75Distal lower limb muscle weakness (HP:0009053)2.67866392
76Arterial thrombosis (HP:0004420)2.66192570
77Aplasia/Hypoplasia of the macula (HP:0008059)2.65837996
78Aplasia/Hypoplasia of the fovea (HP:0008060)2.60183449
79Hypoplasia of the fovea (HP:0007750)2.60183449
80Granulocytopenia (HP:0001913)2.59677517
81Aplasia of the musculature (HP:0100854)2.57888115
82Generalized hypopigmentation of hair (HP:0011358)2.56836929
83Albinism (HP:0001022)2.56534431
84Chest pain (HP:0100749)2.56449280
85Osteolytic defects of the hand bones (HP:0009699)2.55679872
86Osteolytic defects of the phalanges of the hand (HP:0009771)2.55679872
87Onycholysis (HP:0001806)2.55442086
88Gastrointestinal infarctions (HP:0005244)2.54765811
89Iris hypopigmentation (HP:0007730)2.54757739
90Cutaneous melanoma (HP:0012056)2.54480189
91Gowers sign (HP:0003391)2.53987598
92Abnormal platelet volume (HP:0011876)2.53144460
93Spontaneous hematomas (HP:0007420)2.51816039
94Meningitis (HP:0001287)2.51519036
95Basal cell carcinoma (HP:0002671)2.49120391
96Mediastinal lymphadenopathy (HP:0100721)2.44718681
97Aplasia/Hypoplasia affecting the retina (HP:0008061)2.44586921
98Asymmetric septal hypertrophy (HP:0001670)2.43331959
99White forelock (HP:0002211)2.42083143
100Bundle branch block (HP:0011710)2.40590987
101Aortic aneurysm (HP:0004942)2.40068422
102Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)2.39167162
103Metaphyseal dysplasia (HP:0100255)2.38722018
104Lymphoma (HP:0002665)2.38687339
105Plantar hyperkeratosis (HP:0007556)2.37842442
106Abnormal auditory evoked potentials (HP:0006958)2.37660714
107Increased IgE level (HP:0003212)2.36959725
108Thrombocytosis (HP:0001894)2.34540780
109Gastrointestinal stroma tumor (HP:0100723)2.32785887
110Encephalitis (HP:0002383)2.32453865
111Spondylolisthesis (HP:0003302)2.32422036
112Easy fatigability (HP:0003388)2.32413126
113Prolonged bleeding time (HP:0003010)2.32281759
114Keratoconjunctivitis sicca (HP:0001097)2.31802125
115Chronic sinusitis (HP:0011109)2.31648990
116Papilloma (HP:0012740)2.30109555
117Verrucae (HP:0200043)2.30109555
118Ureteral stenosis (HP:0000071)2.28290466
119Arterial tortuosity (HP:0005116)2.27679398
120Abnormal glucose tolerance (HP:0001952)2.27451608
121Patchy hypopigmentation of hair (HP:0011365)2.26516849
122Hypergammaglobulinemia (HP:0010702)2.25038084
123Round ear (HP:0100830)2.24576929
124Agammaglobulinemia (HP:0004432)2.23433369
125Lip pit (HP:0100267)2.22647741
126Fatigue (HP:0012378)2.22287095
127Abnormality of the calf musculature (HP:0001430)2.22276443
128Generalized hypopigmentation (HP:0007513)2.19509760
129Cheilitis (HP:0100825)2.18806765
130Hypoplasia of the iris (HP:0007676)2.17777879
131Dislocated radial head (HP:0003083)2.17646635
132Abnormality of the fovea (HP:0000493)2.16575852
133Reduced subcutaneous adipose tissue (HP:0003758)2.16449294
134Hypoplasia of the thymus (HP:0000778)2.16179437
135Increased mean platelet volume (HP:0011877)2.15563244
136Trigonocephaly (HP:0000243)2.14648026
137Hypopigmentation of the fundus (HP:0007894)2.14046957
138Periodontitis (HP:0000704)2.14023980
139Gingival bleeding (HP:0000225)2.13638139
140Emphysema (HP:0002097)2.12801297
141Abnormality of the radial head (HP:0003995)2.12694984
142Fetal akinesia sequence (HP:0001989)2.12387362
143Exercise-induced myalgia (HP:0003738)2.11855370
144Subacute progressive viral hepatitis (HP:0006572)2.11738542
145Recurrent skin infections (HP:0001581)2.11527206
146Obstructive lung disease (HP:0006536)2.11477881
147Chronic obstructive pulmonary disease (HP:0006510)2.11477881
148Ureteral obstruction (HP:0006000)2.09321342
149Epistaxis (HP:0000421)2.08350687
150Vascular tortuosity (HP:0004948)2.08284551
151Recurrent abscess formation (HP:0002722)2.06941355
152Persistence of primary teeth (HP:0006335)2.06460790
153Keratoconjunctivitis (HP:0001096)2.04894476
154Pulmonary embolism (HP:0002204)2.04595402
155Recurrent otitis media (HP:0000403)2.04542999
156Colitis (HP:0002583)2.04361528
157Micronodular cirrhosis (HP:0001413)2.03776946
158Abnormality of the frontal sinuses (HP:0002687)2.03588089
159Autoimmune thrombocytopenia (HP:0001973)2.03152827
160Pterygium (HP:0001059)2.02969739
161Cystic hygroma (HP:0000476)2.02632084
162Bicuspid aortic valve (HP:0001647)2.02510594
163Ulnar deviation of the wrist (HP:0003049)2.01406400
164Diplopia (HP:0000651)2.00816044
165Abnormality of binocular vision (HP:0011514)2.00816044
166Alopecia of scalp (HP:0002293)1.97414409
167Abnormality of oral frenula (HP:0000190)1.96382296
168Right ventricular cardiomyopathy (HP:0011663)1.95695019
169Frequent falls (HP:0002359)1.93772805
170Type 1 muscle fiber predominance (HP:0003803)1.93284467
171Thick nail (HP:0001805)1.92926454
172Papilledema (HP:0001085)1.91582696
173Abnormality of the prostate (HP:0008775)1.90085660
174Bilateral sensorineural hearing impairment (HP:0008619)1.89261810
175Anhidrosis (HP:0000970)1.88893151
176Areflexia of lower limbs (HP:0002522)1.88565836
177Dysmetric saccades (HP:0000641)1.87811224
178Premature graying of hair (HP:0002216)1.87408773
179Cerebral aneurysm (HP:0004944)1.86156046
180Lipoatrophy (HP:0100578)1.84311253
181Nail dystrophy (HP:0008404)1.82590486
182Distal arthrogryposis (HP:0005684)1.76462020
183Palmoplantar hyperkeratosis (HP:0000972)1.75883956
184Akinesia (HP:0002304)1.73910359
185Ventricular tachycardia (HP:0004756)1.72501360
186EMG: myopathic abnormalities (HP:0003458)1.72384184

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK6.37582371
2MAP4K15.55127609
3MUSK3.79433861
4FGFR43.78155763
5ITK3.66544224
6FRK3.34435258
7JAK33.25986408
8ZAP703.04405630
9SCYL22.88186262
10TAOK32.79245614
11MAP3K122.71012430
12FGFR32.65189661
13TYK22.65100025
14STK102.54713970
15MST1R2.44577122
16IKBKE2.39200616
17PIK3CA2.27431549
18JAK12.26714906
19MYLK2.24390222
20OBSCN2.12111430
21PIK3CG2.11618507
22LCK1.90902733
23NLK1.84277648
24TEC1.81077882
25EEF2K1.69951996
26MAP3K141.68169883
27GRK61.61673439
28TGFBR21.56912313
29HCK1.51588890
30NEK61.51311110
31BMPR21.49329248
32PRKCQ1.43885559
33CSK1.42747534
34MAP3K131.38309300
35FGFR21.35426695
36EIF2AK31.34593575
37MAPKAPK31.32385489
38KIT1.30936187
39CAMKK21.30705092
40SYK1.30256540
41LATS11.29270624
42STK381.27733961
43EPHA21.26641606
44TBK11.26354368
45ERBB31.26111461
46MET1.25662640
47PRKCH1.25529581
48MAP3K31.23143873
49BTK1.21569629
50MARK31.19612742
51MAP3K71.19187506
52PKN21.18064253
53EPHA31.17712137
54TTN1.17319868
55PTK2B1.16159765
56AKT31.14802487
57STK391.05240436
58RPS6KB21.03214380
59FER1.03089061
60JAK21.01975140
61KDR0.97219412
62TYRO30.96005145
63LRRK20.95558292
64CDK120.92961976
65MAP3K20.92938932
66IKBKB0.92563647
67DMPK0.89545761
68SIK20.87143637
69MAP3K100.86819749
70IRAK40.86768570
71PDGFRB0.84943355
72PAK30.83377295
73MAP2K10.81027614
74CHUK0.80741577
75MST40.78486232
76CLK10.77915723
77FGFR10.76739592
78TRIM280.74795583
79NME20.73655829
80FES0.73129845
81TRIB30.70442331
82CDK80.70307909
83EIF2AK20.69409414
84EIF2AK10.69319668
85HIPK20.68501455
86PIM10.65853253
87MAP2K20.65779858
88TNK20.65545603
89LYN0.64348450
90EPHB10.63800697
91NTRK20.61883675
92ACVR1B0.60913858
93MARK20.60775285
94CDK60.60491944
95BLK0.59972545
96PDK10.59170260
97RPS6KA40.57871275
98LIMK10.57649511
99IRAK10.56386903
100MAPK70.54923181
101TGFBR10.53591785
102MELK0.52652700
103FLT30.50464045
104ILK0.49361717
105PRKD20.48249847
106BMPR1B0.48074895
107IGF1R0.47884656
108TAOK10.47831497
109RIPK10.47346433
110SIK30.46672094
111PDGFRA0.46208158
112ADRBK10.45113948
113PTK20.44679790
114STK30.43693766
115CSF1R0.43134453
116INSR0.42797795
117CDK90.42392042
118MAP2K30.41777836
119PAK40.41485156
120CDK40.39855400
121NUAK10.39755615
122FYN0.39200891
123MAPK120.38031421
124BRD40.37618555
125MAPK110.36476236
126SGK30.35547296
127RET0.35244054
128STK40.34361934
129ALK0.33440174
130PTK60.33123174
131NEK90.32403578
132STK240.30317361
133EGFR0.29440524
134CAMK1G0.29082966
135IRAK20.28482234
136PRKD10.28320700
137RPS6KA50.27299631
138TSSK60.26128304
139MAPKAPK20.25899646
140CAMK1D0.25823561
141TRPM70.24771021
142MAPK30.23840258
143ROCK20.22610914
144SIK10.19163234
145ABL10.17390762

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053405.04944624
2T cell receptor signaling pathway_Homo sapiens_hsa046603.97889693
3Inflammatory bowel disease (IBD)_Homo sapiens_hsa053213.31897964
4Allograft rejection_Homo sapiens_hsa053303.00263784
5Intestinal immune network for IgA production_Homo sapiens_hsa046722.79725753
6Measles_Homo sapiens_hsa051622.58169253
7Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.51003670
8Autoimmune thyroid disease_Homo sapiens_hsa053202.43549850
9NF-kappa B signaling pathway_Homo sapiens_hsa040642.30638972
10Hematopoietic cell lineage_Homo sapiens_hsa046402.21955496
11Graft-versus-host disease_Homo sapiens_hsa053322.21676505
12Asthma_Homo sapiens_hsa053102.01824432
13Viral myocarditis_Homo sapiens_hsa054161.96329344
14Jak-STAT signaling pathway_Homo sapiens_hsa046301.94925510
15Osteoclast differentiation_Homo sapiens_hsa043801.90087393
16Antigen processing and presentation_Homo sapiens_hsa046121.78151238
17Leishmaniasis_Homo sapiens_hsa051401.74612320
18Circadian rhythm_Homo sapiens_hsa047101.69695239
19B cell receptor signaling pathway_Homo sapiens_hsa046621.68549122
20Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.51536518
21Toxoplasmosis_Homo sapiens_hsa051451.49250224
22Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.39432141
23Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.37402078
24Chemokine signaling pathway_Homo sapiens_hsa040621.34686221
25Thyroid cancer_Homo sapiens_hsa052161.30872141
26Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.29238865
27Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.28412209
28ECM-receptor interaction_Homo sapiens_hsa045121.28286243
29Type I diabetes mellitus_Homo sapiens_hsa049401.28066100
30Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.27232255
31Leukocyte transendothelial migration_Homo sapiens_hsa046701.25486996
32Hepatitis B_Homo sapiens_hsa051611.22852492
33RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.22464150
34Herpes simplex infection_Homo sapiens_hsa051681.17813811
35Pancreatic cancer_Homo sapiens_hsa052121.15132414
36Acute myeloid leukemia_Homo sapiens_hsa052211.12881520
37Platelet activation_Homo sapiens_hsa046111.12636223
38HTLV-I infection_Homo sapiens_hsa051661.12394050
39Chronic myeloid leukemia_Homo sapiens_hsa052201.06861259
40Glioma_Homo sapiens_hsa052141.02129382
41AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.00339209
42TNF signaling pathway_Homo sapiens_hsa046680.97000988
43Prolactin signaling pathway_Homo sapiens_hsa049170.96290115
44Colorectal cancer_Homo sapiens_hsa052100.95154513
45Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.93820585
46Influenza A_Homo sapiens_hsa051640.92646903
47Toll-like receptor signaling pathway_Homo sapiens_hsa046200.90491804
48Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.89985170
49ErbB signaling pathway_Homo sapiens_hsa040120.87029543
50Apoptosis_Homo sapiens_hsa042100.84956215
51VEGF signaling pathway_Homo sapiens_hsa043700.82950500
52NOD-like receptor signaling pathway_Homo sapiens_hsa046210.82534111
53Shigellosis_Homo sapiens_hsa051310.81792963
54Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.81653346
55SNARE interactions in vesicular transport_Homo sapiens_hsa041300.81189140
56Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.79848830
57Viral carcinogenesis_Homo sapiens_hsa052030.79374801
58Sphingolipid metabolism_Homo sapiens_hsa006000.78950039
59Melanoma_Homo sapiens_hsa052180.77823531
60Malaria_Homo sapiens_hsa051440.76932879
61* Phosphatidylinositol signaling system_Homo sapiens_hsa040700.72465829
62Thyroid hormone signaling pathway_Homo sapiens_hsa049190.72294286
63Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.72030602
64Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.71209920
65ABC transporters_Homo sapiens_hsa020100.71036122
66Notch signaling pathway_Homo sapiens_hsa043300.68605206
67Epstein-Barr virus infection_Homo sapiens_hsa051690.68497435
68Renal cell carcinoma_Homo sapiens_hsa052110.68016804
69Hepatitis C_Homo sapiens_hsa051600.67669088
70Dilated cardiomyopathy_Homo sapiens_hsa054140.67529232
71Regulation of actin cytoskeleton_Homo sapiens_hsa048100.66054405
72Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.65591692
73Amoebiasis_Homo sapiens_hsa051460.65572429
74Small cell lung cancer_Homo sapiens_hsa052220.65427055
75Transcriptional misregulation in cancer_Homo sapiens_hsa052020.64539080
76Tuberculosis_Homo sapiens_hsa051520.64456673
77PI3K-Akt signaling pathway_Homo sapiens_hsa041510.64296850
78MAPK signaling pathway_Homo sapiens_hsa040100.64138632
79Pancreatic secretion_Homo sapiens_hsa049720.63678575
80Tight junction_Homo sapiens_hsa045300.63444608
81Non-small cell lung cancer_Homo sapiens_hsa052230.63083200
82mTOR signaling pathway_Homo sapiens_hsa041500.62868796
83Insulin signaling pathway_Homo sapiens_hsa049100.62069841
84Neurotrophin signaling pathway_Homo sapiens_hsa047220.60899317
85Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.60344889
86Calcium signaling pathway_Homo sapiens_hsa040200.60026959
87Rap1 signaling pathway_Homo sapiens_hsa040150.59716273
88Renin secretion_Homo sapiens_hsa049240.59490589
89Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.59213833
90Endocytosis_Homo sapiens_hsa041440.57139356
91Longevity regulating pathway - mammal_Homo sapiens_hsa042110.55570577
92Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.52893554
93Salivary secretion_Homo sapiens_hsa049700.52593946
94Salmonella infection_Homo sapiens_hsa051320.51759429
95FoxO signaling pathway_Homo sapiens_hsa040680.49867556
96Rheumatoid arthritis_Homo sapiens_hsa053230.48396288
97Insulin resistance_Homo sapiens_hsa049310.47770286
98Adherens junction_Homo sapiens_hsa045200.47640558
99HIF-1 signaling pathway_Homo sapiens_hsa040660.47587113
100Proteoglycans in cancer_Homo sapiens_hsa052050.46130598
101Sphingolipid signaling pathway_Homo sapiens_hsa040710.44788512
102Choline metabolism in cancer_Homo sapiens_hsa052310.44150077
103cGMP-PKG signaling pathway_Homo sapiens_hsa040220.43742164
104Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.42949420
105Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.42928202
106Legionellosis_Homo sapiens_hsa051340.42486761
107* Inositol phosphate metabolism_Homo sapiens_hsa005620.41544683
108Pathways in cancer_Homo sapiens_hsa052000.41413352
109Staphylococcus aureus infection_Homo sapiens_hsa051500.41290408
110Oxytocin signaling pathway_Homo sapiens_hsa049210.40861437
111Focal adhesion_Homo sapiens_hsa045100.38572525
112Endometrial cancer_Homo sapiens_hsa052130.37967725
113p53 signaling pathway_Homo sapiens_hsa041150.36836610
114Prostate cancer_Homo sapiens_hsa052150.36797604
115Adipocytokine signaling pathway_Homo sapiens_hsa049200.36718240
116Phospholipase D signaling pathway_Homo sapiens_hsa040720.36284852
117MicroRNAs in cancer_Homo sapiens_hsa052060.35951882
118Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.35592684
119Type II diabetes mellitus_Homo sapiens_hsa049300.34892702
120Pertussis_Homo sapiens_hsa051330.32983943
121Vascular smooth muscle contraction_Homo sapiens_hsa042700.30713581
122Carbohydrate digestion and absorption_Homo sapiens_hsa049730.30097164
123Dorso-ventral axis formation_Homo sapiens_hsa043200.27085318

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