INPP5B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of a family of inositol polyphosphate-5-phosphatases. These enzymes function in the regulation of calcium signaling by inactivating inositol phosphates. The encoded protein is localized to the cytosol and mitochondria, and associates with membranes through an isoprenyl modification near the C-terminus. Alternatively spliced transcript variants of this gene have been described. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)6.65347532
2antigen processing and presentation of endogenous peptide antigen (GO:0002483)6.65347532
3antigen processing and presentation of endogenous antigen (GO:0019883)6.24721311
4antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.44954280
5fucose catabolic process (GO:0019317)4.83175524
6L-fucose metabolic process (GO:0042354)4.83175524
7L-fucose catabolic process (GO:0042355)4.83175524
8positive regulation of gamma-delta T cell activation (GO:0046645)4.75918807
9regulation of T-helper 1 cell differentiation (GO:0045625)4.73453960
10negative thymic T cell selection (GO:0045060)4.71914102
11DNA deamination (GO:0045006)4.66863474
12positive regulation of alpha-beta T cell proliferation (GO:0046641)4.63041508
13negative T cell selection (GO:0043383)4.60386701
14positive regulation of interleukin-2 biosynthetic process (GO:0045086)4.55192413
15positive regulation of natural killer cell differentiation (GO:0032825)4.54162044
16regulation of alpha-beta T cell proliferation (GO:0046640)4.41919461
17regulation of T cell tolerance induction (GO:0002664)4.09049177
18cellular response to type I interferon (GO:0071357)4.06840329
19type I interferon signaling pathway (GO:0060337)4.06840329
20response to type I interferon (GO:0034340)4.05631590
21positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)3.93592945
22regulation of activation of Janus kinase activity (GO:0010533)3.92896216
23behavioral response to nicotine (GO:0035095)3.92597483
24positive regulation of T-helper cell differentiation (GO:0045624)3.79459160
25tryptophan catabolic process (GO:0006569)3.78214404
26indole-containing compound catabolic process (GO:0042436)3.78214404
27indolalkylamine catabolic process (GO:0046218)3.78214404
28positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.71905775
29antigen processing and presentation via MHC class Ib (GO:0002475)3.66746721
30regulation of gamma-delta T cell differentiation (GO:0045586)3.65554017
31rRNA catabolic process (GO:0016075)3.65022351
32regulation of hypersensitivity (GO:0002883)3.61890056
33regulation of natural killer cell differentiation (GO:0032823)3.58514532
34T-helper 1 type immune response (GO:0042088)3.55916036
35regulation of interleukin-12 biosynthetic process (GO:0045075)3.55567877
36leukocyte aggregation (GO:0070486)3.55474863
37response to interleukin-15 (GO:0070672)3.54794349
38regulation of RIG-I signaling pathway (GO:0039535)3.53220591
39negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.51468178
40negative regulation of translation, ncRNA-mediated (GO:0040033)3.51468178
41regulation of translation, ncRNA-mediated (GO:0045974)3.51468178
42positive regulation of interleukin-2 production (GO:0032743)3.50922194
43tryptophan metabolic process (GO:0006568)3.49850291
44response to pheromone (GO:0019236)3.49099783
45thymic T cell selection (GO:0045061)3.47659152
46NIK/NF-kappaB signaling (GO:0038061)3.47302514
47natural killer cell differentiation (GO:0001779)3.46925472
48regulation of gamma-delta T cell activation (GO:0046643)3.45796115
49T cell costimulation (GO:0031295)3.43765290
50positive regulation of interferon-alpha production (GO:0032727)3.43535957
51T cell selection (GO:0045058)3.42722164
52indolalkylamine metabolic process (GO:0006586)3.41556617
53positive regulation of interleukin-12 production (GO:0032735)3.40438737
54positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)3.38524772
55interferon-gamma production (GO:0032609)3.38435018
56lymphocyte costimulation (GO:0031294)3.37853554
57Arp2/3 complex-mediated actin nucleation (GO:0034314)3.37838765
58neural tube formation (GO:0001841)3.37394112
59cellular ketone body metabolic process (GO:0046950)3.34625072
60positive thymic T cell selection (GO:0045059)3.31557427
61regulation of interleukin-2 biosynthetic process (GO:0045076)3.31163031
62T cell migration (GO:0072678)3.29457076
63regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)3.28083476
64detection of light stimulus involved in sensory perception (GO:0050962)3.27220218
65detection of light stimulus involved in visual perception (GO:0050908)3.27220218
66regulation of interferon-alpha production (GO:0032647)3.24994455
67kynurenine metabolic process (GO:0070189)3.24623070
68natural killer cell mediated immunity (GO:0002228)3.24264349
69natural killer cell mediated cytotoxicity (GO:0042267)3.24264349
70positive regulation of humoral immune response (GO:0002922)3.24256378
71regulation of T-helper cell differentiation (GO:0045622)3.24126754
72natural killer cell activation (GO:0030101)3.23054624
73epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.22978966
74regulation of tolerance induction (GO:0002643)3.21964097
75positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.21519639
76positive regulation of B cell differentiation (GO:0045579)3.18785179
77positive regulation of isotype switching (GO:0045830)3.18212955
78positive regulation of T cell cytokine production (GO:0002726)3.17824729
79positive regulation of interleukin-17 production (GO:0032740)3.16289167
80cellular response to zinc ion (GO:0071294)3.13252669
81regulation of T-helper 1 type immune response (GO:0002825)3.12389564
82interferon-gamma-mediated signaling pathway (GO:0060333)3.11959482
83regulation of memory T cell differentiation (GO:0043380)3.10506040
84regulation of type I interferon-mediated signaling pathway (GO:0060338)3.10480100
85defense response to protozoan (GO:0042832)3.09847334
86myeloid dendritic cell differentiation (GO:0043011)3.09409362
87positive regulation of antigen processing and presentation (GO:0002579)3.09121876
88myeloid dendritic cell activation (GO:0001773)3.09026179
89regulation of B cell differentiation (GO:0045577)3.06668994
90protein K11-linked deubiquitination (GO:0035871)3.04131993
91positive regulation of defense response to virus by host (GO:0002230)3.04045370
92ketone body metabolic process (GO:1902224)3.03237126
93regulation of T-helper 2 cell differentiation (GO:0045628)3.02958324
94cellular response to interleukin-15 (GO:0071350)3.00964357
95cytidine deamination (GO:0009972)3.00726663
96cytidine metabolic process (GO:0046087)3.00726663
97cytidine catabolic process (GO:0006216)3.00726663
98regulation of natural killer cell activation (GO:0032814)2.98650860
99regulation of dendritic cell antigen processing and presentation (GO:0002604)2.98608280
100double-strand break repair via homologous recombination (GO:0000724)2.97651566
101recombinational repair (GO:0000725)2.96631709
102replication fork processing (GO:0031297)2.93039860
103regulation of CD4-positive, alpha-beta T cell activation (GO:2000514)2.92415490
104neutrophil activation involved in immune response (GO:0002283)2.91435135
105positive regulation of T-helper 1 type immune response (GO:0002827)2.90978237
106regulation of B cell receptor signaling pathway (GO:0050855)2.90614620
107positive regulation of natural killer cell mediated immunity (GO:0002717)2.90531376
108positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)2.90531376
109immunoglobulin mediated immune response (GO:0016064)2.90423895
110negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.89972906
111negative regulation of cell killing (GO:0031342)2.89972906
112regulation of immunoglobulin secretion (GO:0051023)2.89597484
113regulation of natural killer cell mediated immunity (GO:0002715)2.88539783
114regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.88539783
115positive regulation of activated T cell proliferation (GO:0042104)2.88137893
116positive regulation of inflammatory response to antigenic stimulus (GO:0002863)2.88019583
117positive regulation of alpha-beta T cell differentiation (GO:0046638)2.87652794
118regulation of interleukin-12 production (GO:0032655)2.87451182
119RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.86266335
120positive regulation of lamellipodium assembly (GO:0010592)2.85877263
121amine catabolic process (GO:0009310)2.85810386
122cellular biogenic amine catabolic process (GO:0042402)2.85810386
123platelet dense granule organization (GO:0060155)2.85769768
124negative regulation of telomere maintenance (GO:0032205)2.85697530
125positive regulation of T cell proliferation (GO:0042102)2.84431164
126regulation of interleukin-17 production (GO:0032660)2.84354934
127response to protozoan (GO:0001562)2.84262379
128negative regulation of DNA-dependent DNA replication (GO:2000104)2.81095177
129negative regulation of interleukin-17 production (GO:0032700)2.80941657
130reciprocal DNA recombination (GO:0035825)2.80163929
131reciprocal meiotic recombination (GO:0007131)2.80163929
132regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)2.78922042
133positive regulation of alpha-beta T cell activation (GO:0046635)2.78746606
134regulation of response to interferon-gamma (GO:0060330)2.78701877
135positive regulation of mRNA catabolic process (GO:0061014)2.75852126
136response to interferon-alpha (GO:0035455)2.75391977
137pyrimidine ribonucleoside catabolic process (GO:0046133)2.75198061
138positive regulation of natural killer cell activation (GO:0032816)2.74802499
139activated T cell proliferation (GO:0050798)2.74800779
140regulation of immune response to tumor cell (GO:0002837)2.74717851
141positive regulation of response to tumor cell (GO:0002836)2.74717851
142regulation of glucokinase activity (GO:0033131)2.73309167
143regulation of hexokinase activity (GO:1903299)2.73309167
144detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.72332874
145mast cell activation involved in immune response (GO:0002279)2.72005234
146mast cell degranulation (GO:0043303)2.72005234
147signal peptide processing (GO:0006465)2.69062032
148B cell receptor signaling pathway (GO:0050853)2.68027970
149NAD biosynthetic process (GO:0009435)2.65345566
150photoreceptor cell maintenance (GO:0045494)2.64090437
151kidney morphogenesis (GO:0060993)2.64087108
152DNA demethylation (GO:0080111)2.63546810
153regulation of nuclear cell cycle DNA replication (GO:0033262)2.58509717
154positive regulation of developmental pigmentation (GO:0048087)2.57869242
155cellular response to exogenous dsRNA (GO:0071360)2.57177877
156centriole replication (GO:0007099)2.54467240
157regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.54162422
158negative regulation of mast cell activation (GO:0033004)2.50823220
159axoneme assembly (GO:0035082)2.47678222
160somatic hypermutation of immunoglobulin genes (GO:0016446)2.46245523
161somatic diversification of immune receptors via somatic mutation (GO:0002566)2.46245523
162fucosylation (GO:0036065)2.46227212
163cell wall macromolecule catabolic process (GO:0016998)2.44990060
164prenylation (GO:0097354)2.44911912
165protein prenylation (GO:0018342)2.44911912
166histone mRNA catabolic process (GO:0071044)2.44889731
167piRNA metabolic process (GO:0034587)2.44450161
168epithelial cilium movement (GO:0003351)2.43171928
169dopamine transport (GO:0015872)2.39202193
170interkinetic nuclear migration (GO:0022027)2.38287923
171respiratory chain complex IV assembly (GO:0008535)2.38133699
172positive regulation of fatty acid transport (GO:2000193)2.37875892
173cilium or flagellum-dependent cell motility (GO:0001539)2.37185131
174purinergic nucleotide receptor signaling pathway (GO:0035590)2.36880758
175positive regulation of granulocyte differentiation (GO:0030854)2.36666060
176phosphatidylinositol acyl-chain remodeling (GO:0036149)2.34896704
177protein-cofactor linkage (GO:0018065)2.34617047
178DNA methylation involved in gamete generation (GO:0043046)2.34065102
179regulation of telomere maintenance (GO:0032204)2.32407910
180indole-containing compound metabolic process (GO:0042430)2.32233556
181histone H3-K9 methylation (GO:0051567)2.31429897
182ncRNA catabolic process (GO:0034661)2.30423015
183mast cell activation (GO:0045576)2.28288176
184positive regulation of T cell mediated cytotoxicity (GO:0001916)2.28085445
185preassembly of GPI anchor in ER membrane (GO:0016254)2.27568766
186DNA double-strand break processing (GO:0000729)2.26007762
187mannosylation (GO:0097502)2.25842225
188regulation of mRNA catabolic process (GO:0061013)2.25742691
189water-soluble vitamin biosynthetic process (GO:0042364)2.25322539

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human5.86507543
2FOXP3_17237761_ChIP-ChIP_TREG_Mouse5.07723175
3IRF1_21803131_ChIP-Seq_MONOCYTES_Human4.90697186
4IRF8_21731497_ChIP-ChIP_J774_Mouse4.42094090
5STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.28119179
6IRF8_22096565_ChIP-ChIP_GC-B_Mouse4.21718303
7ZNF274_21170338_ChIP-Seq_K562_Hela3.64810932
8MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.34773494
9VDR_22108803_ChIP-Seq_LS180_Human3.03008344
10BP1_19119308_ChIP-ChIP_Hs578T_Human2.97577805
11FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.93551284
12GATA1_22025678_ChIP-Seq_K562_Human2.89642943
13* STAT4_19710469_ChIP-ChIP_TH1__Mouse2.87664606
14STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.82716066
15IRF8_27001747_Chip-Seq_BMDM_Mouse2.77779596
16SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.68723594
17ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.64882072
18* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.62980223
19SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.59369505
20MYB_21317192_ChIP-Seq_ERMYB_Mouse2.54099931
21MYB_26560356_Chip-Seq_TH2_Human2.48856570
22E2F7_22180533_ChIP-Seq_HELA_Human2.46065287
23FLI1_27457419_Chip-Seq_LIVER_Mouse2.43941395
24EGR1_19374776_ChIP-ChIP_THP-1_Human2.40523315
25RUNX_20019798_ChIP-Seq_JUKART_Human2.40215758
26* MAF_26560356_Chip-Seq_TH1_Human2.38486698
27IGF1R_20145208_ChIP-Seq_DFB_Human2.28573992
28RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.21903943
29GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.21511630
30NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.20395011
31RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.16696164
32MYB_26560356_Chip-Seq_TH1_Human2.15652324
33NOTCH1_21737748_ChIP-Seq_TLL_Human2.12937351
34FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.12225944
35GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.10042592
36SCL_19346495_ChIP-Seq_HPC-7_Human2.09051039
37EWS_26573619_Chip-Seq_HEK293_Human2.03382662
38EZH2_22144423_ChIP-Seq_EOC_Human2.03089055
39POU3F2_20337985_ChIP-ChIP_501MEL_Human2.01012591
40ZFP57_27257070_Chip-Seq_ESCs_Mouse1.96265321
41MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.95102070
42GBX2_23144817_ChIP-Seq_PC3_Human1.93204663
43SPI1_23547873_ChIP-Seq_NB4_Human1.91203278
44SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.90509680
45NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.89596607
46RXR_22158963_ChIP-Seq_LIVER_Mouse1.86807588
47MYC_22102868_ChIP-Seq_BL_Human1.85685202
48VDR_21846776_ChIP-Seq_THP-1_Human1.83938706
49UTX_26944678_Chip-Seq_JUKART_Human1.83593217
50STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.83508767
51HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.83045427
52ER_23166858_ChIP-Seq_MCF-7_Human1.82283246
53BRD4_27068464_Chip-Seq_AML-cells_Mouse1.81779183
54EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.80434009
55RUNX1_22412390_ChIP-Seq_EML_Mouse1.79625563
56PPARA_22158963_ChIP-Seq_LIVER_Mouse1.79416433
57SALL1_21062744_ChIP-ChIP_HESCs_Human1.77763080
58TAF15_26573619_Chip-Seq_HEK293_Human1.76849487
59EGR1_23403033_ChIP-Seq_LIVER_Mouse1.75660013
60PCGF2_27294783_Chip-Seq_ESCs_Mouse1.74846394
61ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.72994781
62IRF1_19129219_ChIP-ChIP_H3396_Human1.66410318
63P300_19829295_ChIP-Seq_ESCs_Human1.65447754
64ELF1_17652178_ChIP-ChIP_JURKAT_Human1.64204163
65FUS_26573619_Chip-Seq_HEK293_Human1.63030592
66FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.62429383
67CTBP2_25329375_ChIP-Seq_LNCAP_Human1.60489311
68CTBP1_25329375_ChIP-Seq_LNCAP_Human1.58943136
69BCAT_22108803_ChIP-Seq_LS180_Human1.57894192
70VDR_24763502_ChIP-Seq_THP-1_Human1.57027945
71PCGF2_27294783_Chip-Seq_NPCs_Mouse1.55087163
72GATA3_27048872_Chip-Seq_THYMUS_Human1.54641771
73STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.53962690
74VDR_23849224_ChIP-Seq_CD4+_Human1.53437264
75* GATA1_19941827_ChIP-Seq_MEL_Mouse1.52429287
76E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.49968914
77CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.49017764
78* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.47432746
79* STAT3_23295773_ChIP-Seq_U87_Human1.47147586
80Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.45936094
81SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.45642841
82MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.45234589
83* SPI1_23127762_ChIP-Seq_K562_Human1.43333938
84E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.42518932
85LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.40227993
86MAF_26560356_Chip-Seq_TH2_Human1.40059596
87PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.40020929
88TCF4_23295773_ChIP-Seq_U87_Human1.39343008
89TCF7_22412390_ChIP-Seq_EML_Mouse1.39050724
90AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.38970225
91* TP53_22573176_ChIP-Seq_HFKS_Human1.37242248
92LXR_22158963_ChIP-Seq_LIVER_Mouse1.34583608
93GATA2_22383799_ChIP-Seq_G1ME_Mouse1.33819612
94NFE2_27457419_Chip-Seq_LIVER_Mouse1.32917715
95SMAD_19615063_ChIP-ChIP_OVARY_Human1.32765780
96PU_27001747_Chip-Seq_BMDM_Mouse1.32170028
97GATA3_26560356_Chip-Seq_TH2_Human1.30673818
98MYC_18940864_ChIP-ChIP_HL60_Human1.30376166
99SUZ12_27294783_Chip-Seq_NPCs_Mouse1.29603975
100BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.28618733
101GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.28375114
102GATA3_21878914_ChIP-Seq_MCF-7_Human1.28296667
103THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.27676364
104GATA1_22383799_ChIP-Seq_G1ME_Mouse1.27625781
105EZH2_27294783_Chip-Seq_NPCs_Mouse1.26710842
106* CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.26659231
107CBP_20019798_ChIP-Seq_JUKART_Human1.26564980
108IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.26564980
109FOXA1_27270436_Chip-Seq_PROSTATE_Human1.25149387
110FOXA1_25329375_ChIP-Seq_VCAP_Human1.25149387
111TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.24670274
112POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.24670274
113MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.24065008
114UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.23807449
115HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.23542528
116EST1_17652178_ChIP-ChIP_JURKAT_Human1.22962890
117CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.21844380
118GABP_17652178_ChIP-ChIP_JURKAT_Human1.20120187
119CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.19941823
120PRDM14_20953172_ChIP-Seq_ESCs_Human1.19360093
121RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.17734635
122CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.16975890
123SOX2_19829295_ChIP-Seq_ESCs_Human1.16712444
124NANOG_19829295_ChIP-Seq_ESCs_Human1.16712444
125LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.15073528
126PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.15065534
127CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.14993918
128* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.13813187
129ETV2_25802403_ChIP-Seq_MESCs_Mouse1.11770089
130AR_21572438_ChIP-Seq_LNCaP_Human1.10935722
131* EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.10699076
132* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.10475494
133PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.10348473
134MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.10102811
135TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.09820033
136* AR_25329375_ChIP-Seq_VCAP_Human1.09817257
137CRX_20693478_ChIP-Seq_RETINA_Mouse1.09329800
138SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.08976449
139FOXA1_21572438_ChIP-Seq_LNCaP_Human1.08750611
140FOXP3_21729870_ChIP-Seq_TREG_Human1.08323443
141EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.07386753
142KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.06472141
143SMRT_27268052_Chip-Seq_Bcells_Human1.06404754
144GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.06286409
145SMAD4_21799915_ChIP-Seq_A2780_Human1.05002463
146AR_20517297_ChIP-Seq_VCAP_Human1.03260479
147FLI1_21867929_ChIP-Seq_TH2_Mouse1.02655472
148NR3C1_21868756_ChIP-Seq_MCF10A_Human1.02543003
149ELK1_19687146_ChIP-ChIP_HELA_Human1.02495689
150TCF4_22108803_ChIP-Seq_LS180_Human1.02250714
151* SRF_21415370_ChIP-Seq_HL-1_Mouse1.00792564
152NCOR_22424771_ChIP-Seq_293T_Human1.00667265
153GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human1.00090933
154CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.99426600
155HOXB7_26014856_ChIP-Seq_BT474_Human0.98591690
156CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.97924413
157RUNX2_22187159_ChIP-Seq_PCA_Human0.97538005
158KDM2B_26808549_Chip-Seq_DND41_Human0.96885229
159GATA3_26560356_Chip-Seq_TH1_Human0.96709674
160ERG_20887958_ChIP-Seq_HPC-7_Mouse0.96076203
161* ELK3_25401928_ChIP-Seq_HUVEC_Human0.95568749
162EGR1_19032775_ChIP-ChIP_M12_Human0.95307809
163PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.95120653
164TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.94669454
165GATA1_19941826_ChIP-Seq_K562_Human0.93845546
166OCT4_21477851_ChIP-Seq_ESCs_Mouse0.93417777
167PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.93001643
168GATA2_19941826_ChIP-Seq_K562_Human0.92650670
169SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.92145403
170HOXB4_20404135_ChIP-ChIP_EML_Mouse0.88273085
171VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.87257659
172RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.86712110
173GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.86293220
174* SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.85067338
175* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.82337869
176VDR_24787735_ChIP-Seq_THP-1_Human0.82219754
177* PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.81310198
178PU.1_20513432_ChIP-Seq_Bcells_Mouse0.81149429
179GATA2_21666600_ChIP-Seq_HMVEC_Human0.79854826
180* NCOR1_26117541_ChIP-Seq_K562_Human0.74179217
181FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.73415525
182CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.73061085
183KDM2B_26808549_Chip-Seq_SUP-B15_Human0.71109277
184* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.71077732
185NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.70558857
186TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.69141609

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation4.72608666
2MP0000685_abnormal_immune_system4.12603561
3MP0005671_abnormal_response_to3.63741800
4MP0009785_altered_susceptibility_to3.29962354
5MP0001790_abnormal_immune_system3.16397210
6MP0005387_immune_system_phenotype3.16397210
7MP0008877_abnormal_DNA_methylation3.06850396
8MP0000569_abnormal_digit_pigmentation2.74291654
9MP0003787_abnormal_imprinting2.69074603
10MP0001800_abnormal_humoral_immune2.65698030
11MP0005000_abnormal_immune_tolerance2.65464471
12MP0003436_decreased_susceptibility_to2.65019889
13MP0003195_calcinosis2.61541134
14MP0005025_abnormal_response_to2.60914839
15MP0003763_abnormal_thymus_physiology2.58162834
16MP0002148_abnormal_hypersensitivity_rea2.54511772
17MP0002723_abnormal_immune_serum2.44482440
18MP0002166_altered_tumor_susceptibility2.42004500
19MP0002452_abnormal_antigen_presenting2.32969602
20MP0001819_abnormal_immune_cell2.30511733
21MP0002420_abnormal_adaptive_immunity2.29059094
22MP0005645_abnormal_hypothalamus_physiol2.25646269
23MP0003724_increased_susceptibility_to2.25433428
24MP0006082_CNS_inflammation2.22229738
25MP0002419_abnormal_innate_immunity2.14208511
26MP0002398_abnormal_bone_marrow2.13796965
27MP0005360_urolithiasis2.11686642
28MP0001986_abnormal_taste_sensitivity2.10120127
29MP0008057_abnormal_DNA_replication2.05904261
30MP0003646_muscle_fatigue2.04108906
31MP0005464_abnormal_platelet_physiology1.96363023
32MP0002138_abnormal_hepatobiliary_system1.95615371
33MP0000716_abnormal_immune_system1.94833763
34MP0002006_tumorigenesis1.89493440
35MP0010155_abnormal_intestine_physiology1.89036213
36MP0005551_abnormal_eye_electrophysiolog1.88906449
37MP0002396_abnormal_hematopoietic_system1.88498492
38MP0009840_abnormal_foam_cell1.87657009
39MP0002405_respiratory_system_inflammati1.86268684
40MP0005174_abnormal_tail_pigmentation1.84619146
41MP0004947_skin_inflammation1.83207961
42MP0001968_abnormal_touch/_nociception1.77734547
43MP0002102_abnormal_ear_morphology1.77179035
44MP0001873_stomach_inflammation1.72634090
45MP0003300_gastrointestinal_ulcer1.70961630
46MP0001845_abnormal_inflammatory_respons1.69853331
47MP0002722_abnormal_immune_system1.69390661
48MP0000689_abnormal_spleen_morphology1.68784629
49MP0001853_heart_inflammation1.66390626
50MP0002429_abnormal_blood_cell1.65467263
51MP0000372_irregular_coat_pigmentation1.64023670
52MP0002139_abnormal_hepatobiliary_system1.63485719
53MP0005310_abnormal_salivary_gland1.58195634
54MP0008469_abnormal_protein_level1.58081218
55MP0002837_dystrophic_cardiac_calcinosis1.56961815
56MP0008058_abnormal_DNA_repair1.56569511
57MP0005253_abnormal_eye_physiology1.56183900
58MP0001348_abnormal_lacrimal_gland1.52551054
59MP0003191_abnormal_cellular_cholesterol1.50775036
60MP0003252_abnormal_bile_duct1.50080708
61MP0004043_abnormal_pH_regulation1.49882707
62MP0006072_abnormal_retinal_apoptosis1.49577245
63MP0004510_myositis1.48676040
64MP0004142_abnormal_muscle_tone1.48549944
65MP0009046_muscle_twitch1.46893171
66MP0008872_abnormal_physiological_respon1.46710862
67MP0009764_decreased_sensitivity_to1.46413819
68MP0009333_abnormal_splenocyte_physiolog1.44229677
69MP0001501_abnormal_sleep_pattern1.44081998
70MP0005365_abnormal_bile_salt1.42276940
71MP0003866_abnormal_defecation1.40370831
72MP0003656_abnormal_erythrocyte_physiolo1.38994013
73MP0005058_abnormal_lysosome_morphology1.36786541
74MP0005397_hematopoietic_system_phenotyp1.36693584
75MP0001545_abnormal_hematopoietic_system1.36693584
76MP0000703_abnormal_thymus_morphology1.35907472
77MP0006292_abnormal_olfactory_placode1.35849451
78MP0002876_abnormal_thyroid_physiology1.34835527
79MP0003303_peritoneal_inflammation1.34624937
80MP0002638_abnormal_pupillary_reflex1.33853638
81MP0002736_abnormal_nociception_after1.33585758
82MP0001533_abnormal_skeleton_physiology1.32308825
83MP0000015_abnormal_ear_pigmentation1.30512555
84MP0010352_gastrointestinal_tract_polyps1.29141181
85MP0008875_abnormal_xenobiotic_pharmacok1.28676464
86MP0003172_abnormal_lysosome_physiology1.22466717
87MP0005084_abnormal_gallbladder_morpholo1.22016673
88MP0009763_increased_sensitivity_to1.16699526
89MP0009745_abnormal_behavioral_response1.15804834
90MP0008995_early_reproductive_senescence1.14822153
91MP0000858_altered_metastatic_potential1.10909963
92MP0004885_abnormal_endolymph1.10191044
93MP0005085_abnormal_gallbladder_physiolo1.08755560
94MP0005167_abnormal_blood-brain_barrier1.08131064
95MP0000609_abnormal_liver_physiology1.08066726
96MP0010094_abnormal_chromosome_stability1.06938977
97MP0004808_abnormal_hematopoietic_stem1.05074070
98MP0002095_abnormal_skin_pigmentation1.04709625
99MP0000604_amyloidosis1.03089631
100MP0002693_abnormal_pancreas_physiology1.03063239
101MP0000427_abnormal_hair_cycle1.02470820
102MP0010329_abnormal_lipoprotein_level1.02243540
103MP0001485_abnormal_pinna_reflex1.00646530
104MP0005083_abnormal_biliary_tract0.99778997
105MP0003448_altered_tumor_morphology0.99069171
106MP0005646_abnormal_pituitary_gland0.98797425
107MP0004782_abnormal_surfactant_physiolog0.97305588
108MP0003136_yellow_coat_color0.96669623
109MP0010307_abnormal_tumor_latency0.96482509
110MP0009765_abnormal_xenobiotic_induced0.95159200
111MP0002735_abnormal_chemical_nociception0.94937695
112MP0006276_abnormal_autonomic_nervous0.94642826
113MP0002272_abnormal_nervous_system0.94518096
114MP0003718_maternal_effect0.93465645
115MP0003786_premature_aging0.93245128
116MP0004147_increased_porphyrin_level0.91593408
117MP0005584_abnormal_enzyme/coenzyme_acti0.91056602
118MP0002733_abnormal_thermal_nociception0.90746563
119MP0006035_abnormal_mitochondrial_morpho0.89002634
120MP0001666_abnormal_nutrient_absorption0.88835018
121MP0002933_joint_inflammation0.87867839
122MP0004924_abnormal_behavior0.87701602
123MP0005386_behavior/neurological_phenoty0.87701602
124MP0005379_endocrine/exocrine_gland_phen0.87676167
125MP0002254_reproductive_system_inflammat0.87645013
126MP0003806_abnormal_nucleotide_metabolis0.87366451
127MP0003045_fibrosis0.87327274
128MP0009643_abnormal_urine_homeostasis0.87243847
129MP0002163_abnormal_gland_morphology0.86230031
130MP0002653_abnormal_ependyma_morphology0.84583538
131MP0010386_abnormal_urinary_bladder0.84098422
132MP0001984_abnormal_olfaction0.83885259
133MP0005389_reproductive_system_phenotype0.83746296
134MP0000490_abnormal_crypts_of0.82888466
135MP0003183_abnormal_peptide_metabolism0.82640099
136MP0005319_abnormal_enzyme/_coenzyme0.82564068
137MP0003186_abnormal_redox_activity0.82436040
138MP0000465_gastrointestinal_hemorrhage0.81679164
139MP0002019_abnormal_tumor_incidence0.81473021
140MP0008775_abnormal_heart_ventricle0.81437665
141MP0005332_abnormal_amino_acid0.81327609
142MP0000230_abnormal_systemic_arterial0.79104242
143MP0000631_abnormal_neuroendocrine_gland0.78089850
144MP0002136_abnormal_kidney_physiology0.77683512
145MP0000343_altered_response_to0.77007254
146MP0000598_abnormal_liver_morphology0.75813093
147MP0001970_abnormal_pain_threshold0.75754196
148MP0002067_abnormal_sensory_capabilities0.73533409
149MP0000371_diluted_coat_color0.73353672
150MP0005377_hearing/vestibular/ear_phenot0.72174250
151MP0003878_abnormal_ear_physiology0.72174250
152MP0000383_abnormal_hair_follicle0.71476019
153MP0010234_abnormal_vibrissa_follicle0.69354950
154MP0003075_altered_response_to0.67107127
155MP0002132_abnormal_respiratory_system0.64713651
156MP0001881_abnormal_mammary_gland0.64300744
157MP0005075_abnormal_melanosome_morpholog0.63991440
158MP0000249_abnormal_blood_vessel0.62612280
159MP0001346_abnormal_lacrimal_gland0.62571659
160MP0005076_abnormal_cell_differentiation0.62354376
161MP0009278_abnormal_bone_marrow0.61792184
162MP0005023_abnormal_wound_healing0.61775503
163MP0002998_abnormal_bone_remodeling0.61338130
164MP0002928_abnormal_bile_duct0.60310857

Predicted human phenotypes

RankGene SetZ-score
1Chronic otitis media (HP:0000389)5.04356317
2Elevated erythrocyte sedimentation rate (HP:0003565)4.71142292
3Eczematoid dermatitis (HP:0000976)4.54620300
4Pancreatic cysts (HP:0001737)4.45974892
5Myositis (HP:0100614)4.42694432
6Increased IgM level (HP:0003496)4.40181961
7Recurrent fungal infections (HP:0002841)4.07058532
8Pancreatic fibrosis (HP:0100732)3.92891833
9Recurrent viral infections (HP:0004429)3.87210246
10Recurrent abscess formation (HP:0002722)3.78407737
11Nasal polyposis (HP:0100582)3.74815575
12Autoimmune thrombocytopenia (HP:0001973)3.74474084
13Recurrent bacterial skin infections (HP:0005406)3.72456146
14Congenital stationary night blindness (HP:0007642)3.69991699
15Abnormality of T cell number (HP:0011839)3.68500800
16Recurrent bronchitis (HP:0002837)3.66556131
17Orchitis (HP:0100796)3.65382590
18Optic neuritis (HP:0100653)3.63819293
19Retrobulbar optic neuritis (HP:0100654)3.63819293
20Stomatitis (HP:0010280)3.58869915
21Abnormality of midbrain morphology (HP:0002418)3.52980447
22Molar tooth sign on MRI (HP:0002419)3.52980447
23Abnormality of the nasal mucosa (HP:0000433)3.48923067
24T lymphocytopenia (HP:0005403)3.47368166
25Nephronophthisis (HP:0000090)3.46666216
26True hermaphroditism (HP:0010459)3.45114406
27Gastrointestinal infarctions (HP:0005244)3.44685084
28Abnormality of the renal cortex (HP:0011035)3.42337662
29IgG deficiency (HP:0004315)3.40659787
30Abnormality of T cells (HP:0002843)3.38966713
31Abnormal delayed hypersensitivity skin test (HP:0002963)3.31571966
32Abnormality of T cell physiology (HP:0011840)3.30638256
33Hypergammaglobulinemia (HP:0010702)3.28049959
34Vasculitis (HP:0002633)3.27918888
35Recurrent cutaneous fungal infections (HP:0011370)3.22235231
36Chronic mucocutaneous candidiasis (HP:0002728)3.22235231
37Recurrent gram-negative bacterial infections (HP:0005420)3.17489994
38Abnormality of the renal medulla (HP:0100957)3.15843792
39Recurrent skin infections (HP:0001581)3.14197879
40Autoimmune hemolytic anemia (HP:0001890)3.09342171
41Interstitial pulmonary disease (HP:0006530)3.08397325
42Gingival bleeding (HP:0000225)3.07111503
43Attenuation of retinal blood vessels (HP:0007843)3.06080967
44Panhypogammaglobulinemia (HP:0003139)3.02907534
45Abnormality of macrophages (HP:0004311)3.02643810
46Chronic diarrhea (HP:0002028)3.01380493
47IgM deficiency (HP:0002850)2.92175298
48Chronic hepatic failure (HP:0100626)2.89088676
49Arterial thrombosis (HP:0004420)2.88484200
50Severe combined immunodeficiency (HP:0004430)2.84690164
51Gaze-evoked nystagmus (HP:0000640)2.83766425
52Tubular atrophy (HP:0000092)2.82269106
53IgA deficiency (HP:0002720)2.78325988
54Mediastinal lymphadenopathy (HP:0100721)2.77976424
55Hyperventilation (HP:0002883)2.75294812
56Hypoplasia of the thymus (HP:0000778)2.74501109
57Abnormality of the fingertips (HP:0001211)2.73210094
58Pulmonary infiltrates (HP:0002113)2.71918004
59Abolished electroretinogram (ERG) (HP:0000550)2.71735346
60Abnormal biliary tract physiology (HP:0012439)2.71627721
61Bile duct proliferation (HP:0001408)2.71627721
62Joint swelling (HP:0001386)2.71617983
63Cystic liver disease (HP:0006706)2.70601438
64Combined immunodeficiency (HP:0005387)2.70368076
65Hemoptysis (HP:0002105)2.69738069
66Leukocytosis (HP:0001974)2.69273416
67Thrombocytosis (HP:0001894)2.69107818
68Encephalitis (HP:0002383)2.67472817
69Gingivitis (HP:0000230)2.66843709
70Petechiae (HP:0000967)2.66716707
71Abnormality of eosinophils (HP:0001879)2.61291723
72Epistaxis (HP:0000421)2.61145581
73Meningitis (HP:0001287)2.61032927
74Eosinophilia (HP:0001880)2.60613610
75Increased IgE level (HP:0003212)2.60493113
76Keratoconjunctivitis sicca (HP:0001097)2.59913997
77Protruding tongue (HP:0010808)2.59199769
78Polydipsia (HP:0001959)2.59052287
79Abnormal drinking behavior (HP:0030082)2.59052287
80Pustule (HP:0200039)2.56709096
81Spontaneous hematomas (HP:0007420)2.56545746
82Anorexia (HP:0002039)2.46895474
83Keratoconjunctivitis (HP:0001096)2.45302889
84Genetic anticipation (HP:0003743)2.44557539
85Medial flaring of the eyebrow (HP:0010747)2.43587897
86Granulocytopenia (HP:0001913)2.41500396
87Abnormal rod and cone electroretinograms (HP:0008323)2.41046028
88Agammaglobulinemia (HP:0004432)2.39689220
89Type II lissencephaly (HP:0007260)2.38255532
90Stomach cancer (HP:0012126)2.37089179
91Abnormality of cells of the lymphoid lineage (HP:0012140)2.36928488
92Progressive inability to walk (HP:0002505)2.34017878
93Congenital hepatic fibrosis (HP:0002612)2.32829434
94Lymphopenia (HP:0001888)2.32804115
95Inflammation of the large intestine (HP:0002037)2.32353140
96Clumsiness (HP:0002312)2.31291632
97Large for gestational age (HP:0001520)2.29921516
98Urticaria (HP:0001025)2.29410654
99Basal ganglia calcification (HP:0002135)2.29056893
100Renal cortical cysts (HP:0000803)2.28173670
101Pulmonary embolism (HP:0002204)2.26532408
102Abnormal platelet volume (HP:0011876)2.25290580
103Gastrointestinal inflammation (HP:0004386)2.25042525
104Thyroiditis (HP:0100646)2.24971046
105Periodontitis (HP:0000704)2.24648664
106Chronic sinusitis (HP:0011109)2.22286287
107Thrombophlebitis (HP:0004418)2.22093932
108Gangrene (HP:0100758)2.22016428
109Chest pain (HP:0100749)2.21215225
110Increased neuronal autofluorescent lipopigment (HP:0002074)2.19654919
111Hepatitis (HP:0012115)2.19604547
112Abnormality of B cell number (HP:0010975)2.18786011
113B lymphocytopenia (HP:0010976)2.18786011
114Birth length less than 3rd percentile (HP:0003561)2.18673161
115Inability to walk (HP:0002540)2.18094549
116Increased cerebral lipofuscin (HP:0011813)2.15472934
117Prolonged bleeding time (HP:0003010)2.15123360
118Abnormality of glutamine family amino acid metabolism (HP:0010902)2.14301571
119Cellulitis (HP:0100658)2.12170675
120Purpura (HP:0000979)2.10824695
121Bronchitis (HP:0012387)2.10652518
122Abnormality of the pons (HP:0007361)2.10464756
123Decreased central vision (HP:0007663)2.10349937
124Colitis (HP:0002583)2.09969542
125Pendular nystagmus (HP:0012043)2.08764772
126Loss of speech (HP:0002371)2.08682157
127Absent rod-and cone-mediated responses on ERG (HP:0007688)2.08567495
128Tetraparesis (HP:0002273)2.07992748
129Polyuria (HP:0000103)2.07492224
130Increased mean platelet volume (HP:0011877)2.06035800
131Amaurosis fugax (HP:0100576)2.04935930
132Furrowed tongue (HP:0000221)2.04172615
133Chronic obstructive pulmonary disease (HP:0006510)2.03204799
134Obstructive lung disease (HP:0006536)2.03204799
135Abnormality of DNA repair (HP:0003254)2.01810484
136Impaired platelet aggregation (HP:0003540)2.01173523
137Abnormal platelet function (HP:0011869)2.01173523
138Emphysema (HP:0002097)2.01098786
139Deep venous thrombosis (HP:0002625)2.00581896
140Progressive cerebellar ataxia (HP:0002073)2.00245999
141Aplasia/Hypoplasia of the spleen (HP:0010451)1.98420088
142Lissencephaly (HP:0001339)1.96527399
143Asplenia (HP:0001746)1.96426604
144Polyneuropathy (HP:0001271)1.93101160
145Fair hair (HP:0002286)1.91705400
146Hypoplasia of the pons (HP:0012110)1.91484017
147Patellar aplasia (HP:0006443)1.87262292
148Sclerocornea (HP:0000647)1.86336792
149Abnormality of alanine metabolism (HP:0010916)1.85984573
150Hyperalaninemia (HP:0003348)1.85984573
151Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.85984573
152Anencephaly (HP:0002323)1.85383734
153Aplasia/Hypoplasia of the fovea (HP:0008060)1.84351730
154Hypoplasia of the fovea (HP:0007750)1.84351730
155Ketosis (HP:0001946)1.80302411
156Hematochezia (HP:0002573)1.79369693
157Hypoplastic iliac wings (HP:0002866)1.79180658
158Decreased electroretinogram (ERG) amplitude (HP:0000654)1.78793671
159Aplasia/Hypoplasia of the uvula (HP:0010293)1.77146712
160Bony spicule pigmentary retinopathy (HP:0007737)1.77008620
161Hypothermia (HP:0002045)1.76080146
162Cerebellar dysplasia (HP:0007033)1.75384525
163Ketoacidosis (HP:0001993)1.74837038
164Decreased circulating renin level (HP:0003351)1.73821570
165Duplicated collecting system (HP:0000081)1.73706339
166Clubbing of toes (HP:0100760)1.73684233
167Abnormality of the renal collecting system (HP:0004742)1.73384919
168Sloping forehead (HP:0000340)1.70993331
169Aplasia/Hypoplasia of the patella (HP:0006498)1.70299754
170Tachypnea (HP:0002789)1.68823441
171Hemiparesis (HP:0001269)1.68135775
172Broad-based gait (HP:0002136)1.67466490
173Neoplasm of the adrenal cortex (HP:0100641)1.67183339
174Hypoalbuminemia (HP:0003073)1.67093099
175Abnormal albumin level (HP:0012116)1.67093099
176Hypoproteinemia (HP:0003075)1.66352431
177Dynein arm defect of respiratory motile cilia (HP:0012255)1.65230733

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK6.45111410
2MAP4K14.55571674
3MAP3K143.73168745
4TYK23.71077186
5TXK3.60366022
6JAK33.29269238
7BMPR1B3.21469191
8TBK12.63748913
9IKBKE2.61877052
10FGFR42.60524725
11ZAP702.56042015
12ADRBK22.55854006
13KIT2.53506401
14JAK12.50000434
15ZAK2.48168737
16EPHB12.18096363
17TLK12.16770617
18BLK2.15835944
19MAP3K132.15372777
20IRAK42.14363595
21IKBKB2.09938794
22MAP3K121.98710548
23STK101.98534966
24PINK11.88741263
25GRK11.82972718
26TAOK31.77502849
27WNK41.76655002
28BTK1.72517183
29ITK1.67328505
30MAP4K21.65570611
31SYK1.58376403
32PTK61.53633044
33ERN11.53311411
34WNK31.51909613
35CHUK1.46488451
36KDR1.38802866
37CSF1R1.38670999
38LCK1.38339409
39MAPK131.37412443
40FGFR31.37345393
41PIM21.36306041
42TESK21.35961019
43MKNK21.34550530
44INSRR1.31164724
45TEC1.30206311
46CSK1.25984611
47OXSR11.25472258
48EIF2AK11.24609103
49JAK21.21955873
50LRRK21.19132133
51TGFBR21.18254239
52TESK11.14380363
53PIM11.11646663
54VRK11.10917636
55TNIK1.09524964
56GRK61.09378252
57HCK1.09327234
58PRKCQ1.08035307
59PTK2B1.06749064
60FLT31.04264253
61DAPK21.02384921
62NEK91.01937768
63EEF2K1.00036283
64IRAK10.98836681
65NLK0.95337753
66STK390.93178537
67ADRBK10.91904367
68EPHA30.91200948
69FGFR20.90425981
70FES0.90413785
71LYN0.89053644
72STK40.88455874
73BRSK20.87533855
74RIPK40.87409272
75TRIM280.87167111
76PAK30.86135416
77RPS6KA40.84334885
78IRAK30.83307990
79MAP3K70.77830913
80BMPR20.76755490
81PAK40.73037857
82MAP3K40.72294082
83SIK10.72093994
84MAP3K110.71919600
85PLK20.71362948
86SCYL20.68815589
87PKN20.68273505
88PIK3CG0.67285107
89MKNK10.66463709
90PASK0.66314572
91MAPKAPK30.65963431
92AKT30.65589109
93TRIB30.63911026
94MAPK110.62084578
95CDK40.62024998
96TIE10.61873347
97STK30.60635775
98CDK120.56978191
99EIF2AK20.55873818
100PLK40.54614933
101SIK20.53886987
102STK110.53870658
103PRKCE0.52040243
104PRKAA20.50270401
105MARK30.49298913
106CDK60.48402960
107DYRK20.47628280
108MAP2K30.47346938
109PLK30.46593858
110ACVR1B0.45431081
111CAMKK20.45250651
112RAF10.43639278
113PIK3CA0.43625821
114PKN10.43535750
115SGK20.42283124
116ARAF0.40588847
117MAPKAPK50.39820192
118STK38L0.39555157
119MST40.39448706
120EIF2AK30.38954235
121MYLK0.38788114
122NUAK10.38688807
123MAP2K60.38500875
124MAP3K80.38378934
125TRPM70.38318771
126MAPK150.37074636
127NTRK30.36264205
128WNK10.35923038
129ATM0.35782927
130PRKAA10.35553543
131SIK30.35505141
132MAP3K100.35115662
133NEK20.34201377
134RPS6KA60.34015679
135ABL10.33061747
136PRKCD0.32505716
137TGFBR10.32388917
138MAPKAPK20.32353742
139PRKCG0.31652722
140CHEK20.31531560
141PDK10.31255390
142MAP3K50.30398995
143EGFR0.28506481
144TNK20.27033164
145STK240.25587614
146IGF1R0.25150206
147DAPK10.24735979
148RPS6KA50.24195061
149NME20.22659458
150ATR0.22491780
151FYN0.22465817
152PRKCH0.21743077
153LIMK10.21118638
154BCKDK0.20834192

Predicted pathways (KEGG)

RankGene SetZ-score
1Allograft rejection_Homo sapiens_hsa053304.29368618
2Graft-versus-host disease_Homo sapiens_hsa053323.52430197
3Primary immunodeficiency_Homo sapiens_hsa053403.47850749
4Intestinal immune network for IgA production_Homo sapiens_hsa046723.39984425
5Measles_Homo sapiens_hsa051622.62868636
6Autoimmune thyroid disease_Homo sapiens_hsa053202.49710079
7Linoleic acid metabolism_Homo sapiens_hsa005912.41274874
8Homologous recombination_Homo sapiens_hsa034402.40861436
9alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.39733318
10Leishmaniasis_Homo sapiens_hsa051402.31715729
11NF-kappa B signaling pathway_Homo sapiens_hsa040642.30224458
12Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.23498007
13Antigen processing and presentation_Homo sapiens_hsa046122.23152825
14Phototransduction_Homo sapiens_hsa047442.18659282
15Butanoate metabolism_Homo sapiens_hsa006502.09598719
16Toll-like receptor signaling pathway_Homo sapiens_hsa046201.99389299
17RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.96745046
18Fanconi anemia pathway_Homo sapiens_hsa034601.96104914
19Viral myocarditis_Homo sapiens_hsa054161.95820157
20Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.92888308
21Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.91456514
22Type I diabetes mellitus_Homo sapiens_hsa049401.89794578
23Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.87047978
24Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.84015366
25Herpes simplex infection_Homo sapiens_hsa051681.80446880
26Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.75954366
27T cell receptor signaling pathway_Homo sapiens_hsa046601.75210467
28Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.72383959
29Non-homologous end-joining_Homo sapiens_hsa034501.69513472
30Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.68589790
31Ether lipid metabolism_Homo sapiens_hsa005651.66143744
32Maturity onset diabetes of the young_Homo sapiens_hsa049501.63001333
33Staphylococcus aureus infection_Homo sapiens_hsa051501.61575327
34Jak-STAT signaling pathway_Homo sapiens_hsa046301.59481134
35Osteoclast differentiation_Homo sapiens_hsa043801.58618250
36Toxoplasmosis_Homo sapiens_hsa051451.58543783
37Influenza A_Homo sapiens_hsa051641.58543452
38Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.58420795
39Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.57851974
40NOD-like receptor signaling pathway_Homo sapiens_hsa046211.56610925
41RNA polymerase_Homo sapiens_hsa030201.51772759
42Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.44226626
43B cell receptor signaling pathway_Homo sapiens_hsa046621.43384664
44Asthma_Homo sapiens_hsa053101.42016644
45Basal transcription factors_Homo sapiens_hsa030221.33532613
46Caffeine metabolism_Homo sapiens_hsa002321.30187694
47Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.30106411
48TNF signaling pathway_Homo sapiens_hsa046681.28981775
49Malaria_Homo sapiens_hsa051441.28357649
50Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.27654236
51Regulation of autophagy_Homo sapiens_hsa041401.26978553
52Hematopoietic cell lineage_Homo sapiens_hsa046401.25692869
53Apoptosis_Homo sapiens_hsa042101.25322494
54Primary bile acid biosynthesis_Homo sapiens_hsa001201.25019165
55Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.21176101
56Chemokine signaling pathway_Homo sapiens_hsa040621.20269678
57Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.16550808
58RNA degradation_Homo sapiens_hsa030181.16291271
59Shigellosis_Homo sapiens_hsa051311.15581500
60ABC transporters_Homo sapiens_hsa020101.14956529
61Olfactory transduction_Homo sapiens_hsa047401.13269451
62Pertussis_Homo sapiens_hsa051331.13098631
63Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.11455088
64Legionellosis_Homo sapiens_hsa051341.09284742
65One carbon pool by folate_Homo sapiens_hsa006701.07046723
66Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.06933928
67Tuberculosis_Homo sapiens_hsa051521.03211820
68Arachidonic acid metabolism_Homo sapiens_hsa005901.02822755
69Hepatitis B_Homo sapiens_hsa051611.01346595
70Pentose and glucuronate interconversions_Homo sapiens_hsa000401.00888047
71Propanoate metabolism_Homo sapiens_hsa006401.00880066
72Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.00814508
73Acute myeloid leukemia_Homo sapiens_hsa052210.99989684
74Arginine biosynthesis_Homo sapiens_hsa002200.98816058
75Dorso-ventral axis formation_Homo sapiens_hsa043200.96966654
76Protein export_Homo sapiens_hsa030600.94193541
77Rheumatoid arthritis_Homo sapiens_hsa053230.93924532
78Hepatitis C_Homo sapiens_hsa051600.92186003
79Taste transduction_Homo sapiens_hsa047420.92173932
80Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.90604633
81Morphine addiction_Homo sapiens_hsa050320.89844891
82Nicotine addiction_Homo sapiens_hsa050330.88710052
83Tryptophan metabolism_Homo sapiens_hsa003800.86365474
84Pancreatic cancer_Homo sapiens_hsa052120.85111470
85Leukocyte transendothelial migration_Homo sapiens_hsa046700.84041097
86Complement and coagulation cascades_Homo sapiens_hsa046100.80539248
87African trypanosomiasis_Homo sapiens_hsa051430.74099274
88Serotonergic synapse_Homo sapiens_hsa047260.73263964
89Nitrogen metabolism_Homo sapiens_hsa009100.69542900
90Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.69258254
91Pentose phosphate pathway_Homo sapiens_hsa000300.68545756
92Ovarian steroidogenesis_Homo sapiens_hsa049130.68391182
93Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.66056257
94Glycerolipid metabolism_Homo sapiens_hsa005610.64468669
95Platelet activation_Homo sapiens_hsa046110.63248088
96Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.62196884
97Peroxisome_Homo sapiens_hsa041460.62187238
98Salmonella infection_Homo sapiens_hsa051320.61817780
99Cyanoamino acid metabolism_Homo sapiens_hsa004600.58585633
100Viral carcinogenesis_Homo sapiens_hsa052030.57419636
101Adipocytokine signaling pathway_Homo sapiens_hsa049200.56156076
102Fatty acid degradation_Homo sapiens_hsa000710.55695567
103Other glycan degradation_Homo sapiens_hsa005110.55385860
104Chronic myeloid leukemia_Homo sapiens_hsa052200.54630112
105Purine metabolism_Homo sapiens_hsa002300.53964326
106p53 signaling pathway_Homo sapiens_hsa041150.53804268
107Calcium signaling pathway_Homo sapiens_hsa040200.52859624
108Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.52275462
109Steroid hormone biosynthesis_Homo sapiens_hsa001400.52048202
110Vascular smooth muscle contraction_Homo sapiens_hsa042700.51805223
111Lysosome_Homo sapiens_hsa041420.51554220
112Circadian entrainment_Homo sapiens_hsa047130.50171879
113Retinol metabolism_Homo sapiens_hsa008300.50027322
114Glycerophospholipid metabolism_Homo sapiens_hsa005640.49809134
115Prolactin signaling pathway_Homo sapiens_hsa049170.49801833
116Nucleotide excision repair_Homo sapiens_hsa034200.47199863
117Alcoholism_Homo sapiens_hsa050340.46464087
118Small cell lung cancer_Homo sapiens_hsa052220.45838210
119Glutamatergic synapse_Homo sapiens_hsa047240.45134421
120Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.45060351
121Insulin secretion_Homo sapiens_hsa049110.45051381
122Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.41914457
123Chemical carcinogenesis_Homo sapiens_hsa052040.41387418
124Transcriptional misregulation in cancer_Homo sapiens_hsa052020.40502443
125Vitamin digestion and absorption_Homo sapiens_hsa049770.40011824
126Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.39920694
127SNARE interactions in vesicular transport_Homo sapiens_hsa041300.39763045
128Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.38435588
129Drug metabolism - other enzymes_Homo sapiens_hsa009830.38169006
130Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.37114014
131Oxidative phosphorylation_Homo sapiens_hsa001900.37054041
132Histidine metabolism_Homo sapiens_hsa003400.36007640
133HTLV-I infection_Homo sapiens_hsa051660.35975142
134Glycosaminoglycan degradation_Homo sapiens_hsa005310.35119699
135AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.34753706
136Epstein-Barr virus infection_Homo sapiens_hsa051690.34397869
137Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.34327224
138Long-term depression_Homo sapiens_hsa047300.32233605
139Pyrimidine metabolism_Homo sapiens_hsa002400.32120358
140Insulin resistance_Homo sapiens_hsa049310.31421479
141Selenocompound metabolism_Homo sapiens_hsa004500.31418481
142Salivary secretion_Homo sapiens_hsa049700.30571637
143GABAergic synapse_Homo sapiens_hsa047270.30520734
144Type II diabetes mellitus_Homo sapiens_hsa049300.30377569
145Amoebiasis_Homo sapiens_hsa051460.30228484
146Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.28873086
147Systemic lupus erythematosus_Homo sapiens_hsa053220.28132997
148Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.27866131
149Neurotrophin signaling pathway_Homo sapiens_hsa047220.27419732
150DNA replication_Homo sapiens_hsa030300.27398769
151PPAR signaling pathway_Homo sapiens_hsa033200.27048061
152Renin-angiotensin system_Homo sapiens_hsa046140.26616992
153Bile secretion_Homo sapiens_hsa049760.24489095
154VEGF signaling pathway_Homo sapiens_hsa043700.23658785
155Carbohydrate digestion and absorption_Homo sapiens_hsa049730.22919316
156Lysine degradation_Homo sapiens_hsa003100.22806714

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »