INPP5F

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is an inositol 1,4,5-trisphosphate (InsP3) 5-phosphatase and contains a Sac domain. The activity of this protein is specific for phosphatidylinositol 4,5-bisphosphate and phosphatidylinositol 3,4,5-trisphosphate. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1pyrimidine nucleobase catabolic process (GO:0006208)5.96613556
2neuron cell-cell adhesion (GO:0007158)5.48175287
3vocalization behavior (GO:0071625)5.31089480
4presynaptic membrane assembly (GO:0097105)4.83418214
5neurotransmitter-gated ion channel clustering (GO:0072578)4.80217474
6regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.75030792
7regulation of short-term neuronal synaptic plasticity (GO:0048172)4.64964144
8nucleobase catabolic process (GO:0046113)4.55205130
9postsynaptic membrane organization (GO:0001941)4.55027953
10synaptic vesicle exocytosis (GO:0016079)4.54639564
11regulation of glutamate receptor signaling pathway (GO:1900449)4.47843094
12regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.47800478
13presynaptic membrane organization (GO:0097090)4.46306161
14regulation of synaptic vesicle exocytosis (GO:2000300)4.35747868
15positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.28666977
16neuron recognition (GO:0008038)4.26254040
17negative regulation of synaptic transmission, GABAergic (GO:0032229)4.14485082
18cerebral cortex radially oriented cell migration (GO:0021799)4.11396014
19protein localization to synapse (GO:0035418)4.09452094
20neurotransmitter secretion (GO:0007269)4.05783794
21ionotropic glutamate receptor signaling pathway (GO:0035235)4.04504519
22neuron-neuron synaptic transmission (GO:0007270)3.97789964
23cell migration in hindbrain (GO:0021535)3.95478501
24cellular potassium ion homeostasis (GO:0030007)3.93787156
25regulation of synaptic vesicle transport (GO:1902803)3.91561051
26synaptic transmission, glutamatergic (GO:0035249)3.84614696
27startle response (GO:0001964)3.84114459
28locomotory exploration behavior (GO:0035641)3.83225618
29gamma-aminobutyric acid transport (GO:0015812)3.82251469
30positive regulation of amino acid transport (GO:0051957)3.81148618
31synaptic vesicle docking involved in exocytosis (GO:0016081)3.71718746
32negative regulation of dendrite morphogenesis (GO:0050774)3.70989336
33axonal fasciculation (GO:0007413)3.69702442
34synaptic vesicle maturation (GO:0016188)3.69621849
35cerebellar granule cell differentiation (GO:0021707)3.68641486
36positive regulation of dendritic spine morphogenesis (GO:0061003)3.65887914
37glutamate secretion (GO:0014047)3.65692506
38glutamate receptor signaling pathway (GO:0007215)3.64182368
39negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.63298474
40regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.62069705
41synapse assembly (GO:0007416)3.57982879
42positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.54383571
43positive regulation of synapse assembly (GO:0051965)3.54186515
44exploration behavior (GO:0035640)3.52669996
45regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.52571280
46negative regulation of dendrite development (GO:2000171)3.52220571
47central nervous system projection neuron axonogenesis (GO:0021952)3.48835184
48membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.48712470
49regulation of synapse structural plasticity (GO:0051823)3.46115569
50neuronal action potential propagation (GO:0019227)3.45379455
51proline transport (GO:0015824)3.41446939
52regulation of glutamate secretion (GO:0014048)3.38370053
53establishment of mitochondrion localization (GO:0051654)3.37838285
54dendrite morphogenesis (GO:0048813)3.35939210
55dendritic spine morphogenesis (GO:0060997)3.32967063
56L-amino acid import (GO:0043092)3.31745769
57dendrite development (GO:0016358)3.31451511
58gamma-aminobutyric acid signaling pathway (GO:0007214)3.29482349
59regulation of synaptic transmission, GABAergic (GO:0032228)3.28897715
60regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.28623774
61sodium ion export (GO:0071436)3.26705168
62neurotransmitter transport (GO:0006836)3.23316555
63layer formation in cerebral cortex (GO:0021819)3.22035491
64transmission of nerve impulse (GO:0019226)3.20488953
65regulation of neuronal synaptic plasticity (GO:0048168)3.20427994
66positive regulation of synaptic transmission, GABAergic (GO:0032230)3.18588482
67regulation of synaptic transmission, glutamatergic (GO:0051966)3.17354415
68adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)3.16851167
69central nervous system myelination (GO:0022010)3.15453275
70axon ensheathment in central nervous system (GO:0032291)3.15453275
71mechanosensory behavior (GO:0007638)3.15039557
72long-term synaptic potentiation (GO:0060291)3.13646833
73regulation of respiratory system process (GO:0044065)3.13271602
74positive regulation of synapse maturation (GO:0090129)3.11862613
75innervation (GO:0060384)3.10865059
76regulation of long-term neuronal synaptic plasticity (GO:0048169)3.10514704
77neuronal ion channel clustering (GO:0045161)3.06911500
78negative regulation of neurotransmitter transport (GO:0051589)3.06069682
79positive regulation of dendritic spine development (GO:0060999)3.04692954
80positive regulation of membrane potential (GO:0045838)3.03485932
81membrane depolarization during action potential (GO:0086010)3.02828533
82regulation of excitatory postsynaptic membrane potential (GO:0060079)3.00513777
83regulation of female receptivity (GO:0045924)2.98622061
84synaptic vesicle endocytosis (GO:0048488)2.96829322
85regulation of cAMP-dependent protein kinase activity (GO:2000479)2.96562275
86regulation of synapse maturation (GO:0090128)2.96497828
87regulation of dendritic spine morphogenesis (GO:0061001)2.94800813
88hippocampus development (GO:0021766)2.94786639
89regulation of neurotransmitter secretion (GO:0046928)2.94529003
90striatum development (GO:0021756)2.94076185
91regulation of neurotransmitter transport (GO:0051588)2.93583315
92regulation of neurotransmitter levels (GO:0001505)2.93098483
93transferrin transport (GO:0033572)2.92901604
94regulation of glycogen (starch) synthase activity (GO:2000465)2.92578926
95auditory behavior (GO:0031223)2.91379625
96axon extension (GO:0048675)2.90915135
97long-term memory (GO:0007616)2.90821132
98cell communication by electrical coupling (GO:0010644)2.90304312
99regulation of NFAT protein import into nucleus (GO:0051532)2.89868513
100limb bud formation (GO:0060174)2.89513971
101female mating behavior (GO:0060180)2.87611668
102positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.86932248
103dopamine receptor signaling pathway (GO:0007212)2.86172384
104negative regulation of neurotransmitter secretion (GO:0046929)2.85871429
105regulation of postsynaptic membrane potential (GO:0060078)2.85109552
106potassium ion homeostasis (GO:0055075)2.84742148
107regulation of synapse assembly (GO:0051963)2.84556514
108cerebellar Purkinje cell differentiation (GO:0021702)2.84331320
109amino acid import (GO:0043090)2.84221792
110central nervous system neuron axonogenesis (GO:0021955)2.84200692
111response to histamine (GO:0034776)2.84187705
112learning (GO:0007612)2.84053084
113establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.83364653
114mitochondrion transport along microtubule (GO:0047497)2.83364653
115serotonin metabolic process (GO:0042428)2.82997193
116behavioral defense response (GO:0002209)2.82725931
117behavioral fear response (GO:0001662)2.82725931
118cochlea development (GO:0090102)2.82314759
119cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.80308615
120adult walking behavior (GO:0007628)2.78931206
121regulation of vesicle fusion (GO:0031338)2.78576824
122potassium ion import (GO:0010107)2.78298133
123neuromuscular process controlling posture (GO:0050884)2.76023971
124membrane depolarization (GO:0051899)2.75124215
125neurotransmitter uptake (GO:0001504)2.74864764
126positive regulation of neurotransmitter transport (GO:0051590)2.74753395
127regulation of synaptic plasticity (GO:0048167)2.72607960
128regulation of calcium ion-dependent exocytosis (GO:0017158)2.72334234
129neuromuscular synaptic transmission (GO:0007274)2.72186872
130neuromuscular process controlling balance (GO:0050885)2.68884546
131negative regulation of cytosolic calcium ion concentration (GO:0051481)2.67672203
132fear response (GO:0042596)2.66152352
133G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.64800312
134synaptic transmission (GO:0007268)2.64590335
135retinal cone cell development (GO:0046549)2.64453511

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.50262509
2GBX2_23144817_ChIP-Seq_PC3_Human4.40067522
3GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.20281958
4TAF15_26573619_Chip-Seq_HEK293_Human2.75801775
5SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.74823217
6JARID2_20064375_ChIP-Seq_MESCs_Mouse2.62885279
7SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.52871088
8REST_21632747_ChIP-Seq_MESCs_Mouse2.48696348
9EZH2_27304074_Chip-Seq_ESCs_Mouse2.43654805
10NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.36795864
11ZFP57_27257070_Chip-Seq_ESCs_Mouse2.34358694
12IGF1R_20145208_ChIP-Seq_DFB_Human2.32399171
13CTBP2_25329375_ChIP-Seq_LNCAP_Human2.23629681
14CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.23266721
15JARID2_20075857_ChIP-Seq_MESCs_Mouse2.22132553
16SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.20457938
17SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.14868331
18TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.14851186
19EZH2_18974828_ChIP-Seq_MESCs_Mouse2.14648726
20RNF2_18974828_ChIP-Seq_MESCs_Mouse2.14648726
21SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.14160786
22* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.03877643
23HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.01508031
24EED_16625203_ChIP-ChIP_MESCs_Mouse1.98032002
25CTBP1_25329375_ChIP-Seq_LNCAP_Human1.97086731
26EZH2_27294783_Chip-Seq_ESCs_Mouse1.96663392
27* REST_18959480_ChIP-ChIP_MESCs_Mouse1.94370408
28MTF2_20144788_ChIP-Seq_MESCs_Mouse1.92423289
29PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.92114093
30SALL1_21062744_ChIP-ChIP_HESCs_Human1.91546400
31POU3F2_20337985_ChIP-ChIP_501MEL_Human1.91533307
32BMI1_23680149_ChIP-Seq_NPCS_Mouse1.88712661
33RNF2_27304074_Chip-Seq_ESCs_Mouse1.87028801
34P300_19829295_ChIP-Seq_ESCs_Human1.85895546
35SUZ12_27294783_Chip-Seq_ESCs_Mouse1.85152050
36SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.84900984
37RARB_27405468_Chip-Seq_BRAIN_Mouse1.81090937
38SMAD4_21799915_ChIP-Seq_A2780_Human1.80550748
39CBX2_27304074_Chip-Seq_ESCs_Mouse1.77936613
40RNF2_27304074_Chip-Seq_NSC_Mouse1.72578713
41AR_21572438_ChIP-Seq_LNCaP_Human1.67383363
42DROSHA_22980978_ChIP-Seq_HELA_Human1.66231804
43ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.66058761
44OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.65559758
45GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.64629354
46* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.61489010
47RBPJ_22232070_ChIP-Seq_NCS_Mouse1.60537387
48SMAD3_21741376_ChIP-Seq_EPCs_Human1.55564671
49RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.54400701
50TOP2B_26459242_ChIP-Seq_MCF-7_Human1.54356389
51FUS_26573619_Chip-Seq_HEK293_Human1.47937206
52* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.44811493
53PIAS1_25552417_ChIP-Seq_VCAP_Human1.44390646
54ER_23166858_ChIP-Seq_MCF-7_Human1.44214794
55AR_25329375_ChIP-Seq_VCAP_Human1.42664744
56PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.40157723
57SOX2_21211035_ChIP-Seq_LN229_Gbm1.40097430
58STAT3_23295773_ChIP-Seq_U87_Human1.36861565
59CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.35437112
60RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.34064250
61RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.31569204
62POU5F1_16153702_ChIP-ChIP_HESCs_Human1.29552060
63SMAD_19615063_ChIP-ChIP_OVARY_Human1.27735522
64* CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.27206995
65AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.24456640
66ZNF274_21170338_ChIP-Seq_K562_Hela1.24081776
67* TCF4_23295773_ChIP-Seq_U87_Human1.23872972
68* ARNT_22903824_ChIP-Seq_MCF-7_Human1.22846723
69TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.22667084
70* RUNX2_22187159_ChIP-Seq_PCA_Human1.20451029
71TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.20081287
72POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.20081287
73* STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.18762064
74* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.18491572
75TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.18291366
76TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.18077117
77NANOG_18555785_Chip-Seq_ESCs_Mouse1.17777294
78* LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.17014101
79* GATA1_26923725_Chip-Seq_HPCs_Mouse1.16482618
80BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.16171327
81* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.16049045
82TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.15766891
83JUN_21703547_ChIP-Seq_K562_Human1.15760262
84SMAD3_21741376_ChIP-Seq_ESCs_Human1.13981967
85FLI1_27457419_Chip-Seq_LIVER_Mouse1.13641636
86VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.13046846
87* YAP1_20516196_ChIP-Seq_MESCs_Mouse1.11851010
88KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.10534636
89FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.10515673
90* AHR_22903824_ChIP-Seq_MCF-7_Human1.09975727
91NR3C1_21868756_ChIP-Seq_MCF10A_Human1.09159986
92VDR_22108803_ChIP-Seq_LS180_Human1.07964539
93AR_19668381_ChIP-Seq_PC3_Human1.07952510
94SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.07136948
95* PRDM14_20953172_ChIP-Seq_ESCs_Human1.07127070
96* MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.06884653
97* NR3C1_23031785_ChIP-Seq_PC12_Mouse1.06745233
98SMAD3_21741376_ChIP-Seq_HESCs_Human1.06408509
99P53_22127205_ChIP-Seq_FIBROBLAST_Human1.05373317
100TBX3_20139965_ChIP-Seq_MESCs_Mouse1.04492662
101E2F1_18555785_Chip-Seq_ESCs_Mouse1.03309239
102TBX3_20139965_ChIP-Seq_ESCs_Mouse1.03264714
103SOX9_26525672_Chip-Seq_HEART_Mouse1.02961174
104TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.02560152
105PCGF2_27294783_Chip-Seq_ESCs_Mouse1.02507913
106ZNF217_24962896_ChIP-Seq_MCF-7_Human1.02218730
107POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.01453702
108MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.01413481
109CDX2_19796622_ChIP-Seq_MESCs_Mouse1.00475870
110CMYC_18555785_Chip-Seq_ESCs_Mouse1.00292980
111* SMAD4_21741376_ChIP-Seq_HESCs_Human1.00159138
112KDM2B_26808549_Chip-Seq_REH_Human1.00027197
113MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.99770272
114RING1B_27294783_Chip-Seq_NPCs_Mouse0.99512525
115RING1B_27294783_Chip-Seq_ESCs_Mouse0.98690159
116EWS_26573619_Chip-Seq_HEK293_Human0.97336775
117CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.97204472
118EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.97077585
119GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.97062496
120P53_22387025_ChIP-Seq_ESCs_Mouse0.96785119

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity4.48103642
2MP0003880_abnormal_central_pattern4.38238699
3MP0003635_abnormal_synaptic_transmissio3.43058569
4MP0004270_analgesia3.27150157
5MP0002063_abnormal_learning/memory/cond3.05349469
6MP0009745_abnormal_behavioral_response2.99259613
7MP0003787_abnormal_imprinting2.95595908
8MP0005423_abnormal_somatic_nervous2.90483626
9MP0009046_muscle_twitch2.81492485
10MP0002822_catalepsy2.75059871
11MP0002064_seizures2.74944416
12MP0002734_abnormal_mechanical_nocicepti2.66769217
13MP0002735_abnormal_chemical_nociception2.64284185
14MP0002572_abnormal_emotion/affect_behav2.60102563
15MP0001968_abnormal_touch/_nociception2.56874710
16MP0001188_hyperpigmentation2.52043688
17MP0000778_abnormal_nervous_system2.51279545
18MP0006276_abnormal_autonomic_nervous2.46680632
19MP0001486_abnormal_startle_reflex2.33419366
20MP0002272_abnormal_nervous_system2.31623642
21MP0002184_abnormal_innervation2.17632670
22MP0002736_abnormal_nociception_after2.13158885
23MP0005646_abnormal_pituitary_gland2.10001118
24MP0001529_abnormal_vocalization2.07708771
25MP0003122_maternal_imprinting2.06532622
26MP0005645_abnormal_hypothalamus_physiol1.98678710
27MP0009780_abnormal_chondrocyte_physiolo1.98125774
28MP0001984_abnormal_olfaction1.93895997
29MP0002067_abnormal_sensory_capabilities1.91558261
30MP0002557_abnormal_social/conspecific_i1.90572817
31MP0002733_abnormal_thermal_nociception1.87344139
32MP0001970_abnormal_pain_threshold1.84697877
33MP0004811_abnormal_neuron_physiology1.80200984
34MP0004924_abnormal_behavior1.78316128
35MP0005386_behavior/neurological_phenoty1.78316128
36MP0001440_abnormal_grooming_behavior1.70319636
37MP0000955_abnormal_spinal_cord1.69180359
38MP0003123_paternal_imprinting1.67620011
39MP0005499_abnormal_olfactory_system1.67411041
40MP0005394_taste/olfaction_phenotype1.67411041
41MP0002876_abnormal_thyroid_physiology1.62843272
42MP0003890_abnormal_embryonic-extraembry1.57515926
43MP0001986_abnormal_taste_sensitivity1.48861263
44MP0002882_abnormal_neuron_morphology1.48256211
45MP0004142_abnormal_muscle_tone1.47117834
46MP0001501_abnormal_sleep_pattern1.47032738
47MP0000015_abnormal_ear_pigmentation1.46091779
48MP0008789_abnormal_olfactory_epithelium1.44137188
49MP0008569_lethality_at_weaning1.44081426
50MP0003283_abnormal_digestive_organ1.40278840
51MP0003119_abnormal_digestive_system1.37686202
52MP0000566_synostosis1.37656777
53MP0002066_abnormal_motor_capabilities/c1.35811539
54MP0003121_genomic_imprinting1.34799795
55MP0004885_abnormal_endolymph1.28084679
56MP0001905_abnormal_dopamine_level1.26138790
57MP0003879_abnormal_hair_cell1.25809853
58MP0004858_abnormal_nervous_system1.24912386
59MP0002152_abnormal_brain_morphology1.23539543
60MP0000631_abnormal_neuroendocrine_gland1.23297030
61MP0002909_abnormal_adrenal_gland1.21536218
62MP0002751_abnormal_autonomic_nervous1.20536507
63MP0001177_atelectasis1.14857786
64MP0004133_heterotaxia1.12116704
65MP0005409_darkened_coat_color1.11562479
66MP0001293_anophthalmia1.05100037
67MP0010386_abnormal_urinary_bladder1.01440069
68MP0002938_white_spotting0.99523624
69MP0003329_amyloid_beta_deposits0.99219539
70MP0003633_abnormal_nervous_system0.98454772
71MP0004742_abnormal_vestibular_system0.97702178
72MP0002752_abnormal_somatic_nervous0.97065398
73MP0002069_abnormal_eating/drinking_beha0.96582158
74MP0003937_abnormal_limbs/digits/tail_de0.95957734
75MP0003631_nervous_system_phenotype0.94367402
76MP0002229_neurodegeneration0.93372453
77MP0003183_abnormal_peptide_metabolism0.92528781
78MP0001963_abnormal_hearing_physiology0.92392658
79MP0006292_abnormal_olfactory_placode0.90665608
80MP0003634_abnormal_glial_cell0.90558223
81MP0005171_absent_coat_pigmentation0.89574664
82MP0001502_abnormal_circadian_rhythm0.88608588
83MP0009672_abnormal_birth_weight0.85896278
84MP0002233_abnormal_nose_morphology0.84180125
85MP0003861_abnormal_nervous_system0.82344690
86MP0000569_abnormal_digit_pigmentation0.81516889
87MP0003136_yellow_coat_color0.80555030
88MP0005187_abnormal_penis_morphology0.80337934
89MP0000049_abnormal_middle_ear0.80032611
90MP0008877_abnormal_DNA_methylation0.79238021
91MP0000026_abnormal_inner_ear0.77709291
92MP0005551_abnormal_eye_electrophysiolog0.76470471
93MP0000579_abnormal_nail_morphology0.76305030
94MP0010030_abnormal_orbit_morphology0.76096611
95MP0004085_abnormal_heartbeat0.75301261
96MP0003632_abnormal_nervous_system0.75154474
97MP0002837_dystrophic_cardiac_calcinosis0.74016845
98MP0000537_abnormal_urethra_morphology0.73973974
99MP0002234_abnormal_pharynx_morphology0.73036235
100MP0000428_abnormal_craniofacial_morphol0.72680284
101MP0002638_abnormal_pupillary_reflex0.72173397
102MP0001299_abnormal_eye_distance/0.72046033
103MP0001943_abnormal_respiration0.71144848
104MP0002102_abnormal_ear_morphology0.70828163
105MP0000751_myopathy0.70817815
106MP0003938_abnormal_ear_development0.70657808
107MP0005253_abnormal_eye_physiology0.69108671
108MP0001485_abnormal_pinna_reflex0.67982084
109MP0002082_postnatal_lethality0.67781684
110MP0010770_preweaning_lethality0.67781684
111MP0000013_abnormal_adipose_tissue0.67070945
112MP0008260_abnormal_autophagy0.66922671
113MP0000681_abnormal_thyroid_gland0.66793820
114MP0001346_abnormal_lacrimal_gland0.66374496
115MP0003567_abnormal_fetal_cardiomyocyte0.65689148
116MP0010769_abnormal_survival0.62819658
117MP0003385_abnormal_body_wall0.62468682
118MP0004134_abnormal_chest_morphology0.62166202
119MP0006072_abnormal_retinal_apoptosis0.60818415
120MP0010768_mortality/aging0.59182274
121MP0004043_abnormal_pH_regulation0.59089334
122MP0002081_perinatal_lethality0.58960805

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)6.07456764
2Atonic seizures (HP:0010819)4.98569369
3Febrile seizures (HP:0002373)4.81284063
4Hyperventilation (HP:0002883)4.48234821
5Epileptic encephalopathy (HP:0200134)4.43861750
6Focal seizures (HP:0007359)4.32158504
7Myokymia (HP:0002411)4.27489373
8Abnormal hair whorl (HP:0010721)4.18884270
9Absence seizures (HP:0002121)3.53479098
10Progressive cerebellar ataxia (HP:0002073)3.45888755
11Abnormality of the corticospinal tract (HP:0002492)3.35548598
12Pheochromocytoma (HP:0002666)3.33163305
13Progressive inability to walk (HP:0002505)3.31603869
14Gait imbalance (HP:0002141)3.31540608
15Excessive salivation (HP:0003781)3.29836776
16Drooling (HP:0002307)3.29836776
17Broad-based gait (HP:0002136)3.29047814
18Polyphagia (HP:0002591)3.26974843
19Dialeptic seizures (HP:0011146)3.12742447
20Generalized tonic-clonic seizures (HP:0002069)3.11512412
21Limb dystonia (HP:0002451)3.06981273
22Protruding tongue (HP:0010808)2.99324037
23Visual hallucinations (HP:0002367)2.98643206
24Ankle clonus (HP:0011448)2.97723298
25Failure to thrive in infancy (HP:0001531)2.91135656
26Neuroendocrine neoplasm (HP:0100634)2.89472753
27Agitation (HP:0000713)2.85408309
28Impaired vibration sensation in the lower limbs (HP:0002166)2.84042331
29Abnormal eating behavior (HP:0100738)2.81339322
30Amblyopia (HP:0000646)2.77939582
31Medial flaring of the eyebrow (HP:0010747)2.73011477
32Insidious onset (HP:0003587)2.72168771
33Termporal pattern (HP:0011008)2.72168771
34Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.70954694
35Degeneration of the lateral corticospinal tracts (HP:0002314)2.70954694
36Nephrogenic diabetes insipidus (HP:0009806)2.68250371
37Poor suck (HP:0002033)2.67251263
38Amyotrophic lateral sclerosis (HP:0007354)2.66233155
39Epileptiform EEG discharges (HP:0011182)2.65272737
40Congenital primary aphakia (HP:0007707)2.64178278
41Abnormality of the labia minora (HP:0012880)2.61543992
42EEG with generalized epileptiform discharges (HP:0011198)2.59494963
43Hypsarrhythmia (HP:0002521)2.56343434
44Sleep apnea (HP:0010535)2.56150803
45Specific learning disability (HP:0001328)2.51579498
46Spastic gait (HP:0002064)2.50237096
47Fetal akinesia sequence (HP:0001989)2.49097335
48Urinary bladder sphincter dysfunction (HP:0002839)2.48544004
49Absent speech (HP:0001344)2.47446718
50Septo-optic dysplasia (HP:0100842)2.46053687
51Urinary urgency (HP:0000012)2.45883255
52Blue irides (HP:0000635)2.45633719
53Truncal ataxia (HP:0002078)2.43696035
54Hepatoblastoma (HP:0002884)2.38591997
55Gaze-evoked nystagmus (HP:0000640)2.38333322
56Akinesia (HP:0002304)2.37575052
57Papillary thyroid carcinoma (HP:0002895)2.37308453
58Aplasia/Hypoplasia of the brainstem (HP:0007362)2.37214219
59Hypoplasia of the brainstem (HP:0002365)2.37214219
60Poor eye contact (HP:0000817)2.36760099
61Inability to walk (HP:0002540)2.34345798
62Mutism (HP:0002300)2.34129042
63Optic nerve hypoplasia (HP:0000609)2.33405601
64Supranuclear gaze palsy (HP:0000605)2.32448081
65Status epilepticus (HP:0002133)2.31954613
66Lissencephaly (HP:0001339)2.27615844
67Anxiety (HP:0000739)2.26762923
68Hemiparesis (HP:0001269)2.25963704
69Abnormal social behavior (HP:0012433)2.23550373
70Impaired social interactions (HP:0000735)2.23550373
71Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.22593763
72Cerebral hypomyelination (HP:0006808)2.21992556
73Abnormality of salivation (HP:0100755)2.21534716
74Genetic anticipation (HP:0003743)2.19484119
75Poor coordination (HP:0002370)2.16710213
76Dysdiadochokinesis (HP:0002075)2.16030849
77Narrow nasal bridge (HP:0000446)2.15750505
78Depression (HP:0000716)2.14959706
79Shoulder girdle muscle weakness (HP:0003547)2.13831679
80Hypothermia (HP:0002045)2.13677663
81Aqueductal stenosis (HP:0002410)2.10813922
82Genital tract atresia (HP:0001827)2.10584087
83Action tremor (HP:0002345)2.10471202
84Hyperthyroidism (HP:0000836)2.08203731
85Vaginal atresia (HP:0000148)2.08024125
86Generalized hypotonia (HP:0001290)2.06189384
87Diplopia (HP:0000651)2.05965015
88Abnormality of binocular vision (HP:0011514)2.05965015
89Lower limb muscle weakness (HP:0007340)2.05469706
90Megalencephaly (HP:0001355)2.05129187
91Exotropia (HP:0000577)2.05012985
92Cutaneous finger syndactyly (HP:0010554)2.01229726
93Scanning speech (HP:0002168)2.00057378
94Morphological abnormality of the pyramidal tract (HP:0002062)1.99752006
95Esotropia (HP:0000565)1.95280202
96Abnormality of the lower motor neuron (HP:0002366)1.94992261
97Torticollis (HP:0000473)1.92229106
98Spastic tetraplegia (HP:0002510)1.91751165
99Intestinal atresia (HP:0011100)1.90802127
100Hypoventilation (HP:0002791)1.86387831
101Oligomenorrhea (HP:0000876)1.85210809
102Gastroesophageal reflux (HP:0002020)1.85019014
103Cutaneous syndactyly (HP:0012725)1.82779978
104Split foot (HP:0001839)1.80568028
105Neoplasm of the peripheral nervous system (HP:0100007)1.79989876
106Stereotypic behavior (HP:0000733)1.79367509
107Dysmetria (HP:0001310)1.78270730
108Intention tremor (HP:0002080)1.77588647
109Muscular hypotonia of the trunk (HP:0008936)1.77577796
110Inappropriate behavior (HP:0000719)1.77081818
111Thickened helices (HP:0000391)1.75221563
112Focal dystonia (HP:0004373)1.75002675
113Paraplegia (HP:0010550)1.74903882
114Stenosis of the external auditory canal (HP:0000402)1.73160727
115Hip dysplasia (HP:0001385)1.73047050
116Impaired smooth pursuit (HP:0007772)1.72505840
117Volvulus (HP:0002580)1.70749329
118Hemiplegia (HP:0002301)1.68268638
119Absent septum pellucidum (HP:0001331)1.68249535
120Colon cancer (HP:0003003)1.67654567
121Impaired vibratory sensation (HP:0002495)1.66994870
122Abnormality of ocular smooth pursuit (HP:0000617)1.66793100
123Bilateral microphthalmos (HP:0007633)1.66696804
124Preaxial foot polydactyly (HP:0001841)1.65413509
125Abnormality of the middle phalanges of the toes (HP:0010183)1.64540105
126Morphological abnormality of the inner ear (HP:0011390)1.63615960
127CNS hypomyelination (HP:0003429)1.62519533
128Aplasia involving bones of the extremities (HP:0009825)1.62266474
129Aplasia involving bones of the upper limbs (HP:0009823)1.62266474
130Aplasia of the phalanges of the hand (HP:0009802)1.62266474
131Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.60818072
132Postural instability (HP:0002172)1.59546771
133Annular pancreas (HP:0001734)1.59244295
134Incomplete penetrance (HP:0003829)1.58668259
135Short hallux (HP:0010109)1.56388406
136Aplasia/Hypoplasia of the hallux (HP:0008362)1.55960243
137Papilledema (HP:0001085)1.54717146
138Abnormality of the septum pellucidum (HP:0007375)1.53523635

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK5.48323894
2MARK15.38817832
3MAP2K73.28007212
4NTRK33.07957194
5MAP3K42.86885432
6MAPK132.54171523
7EPHA42.51813443
8AKT32.35800511
9MINK12.20378145
10DYRK22.18426098
11NTRK22.14352606
12SGK22.11172374
13SGK2231.95112805
14SGK4941.95112805
15PLK21.86535953
16MAP3K121.72683945
17ERBB31.59767206
18PRPF4B1.57664146
19SIK31.55432814
20WNK31.55060953
21YES11.52807553
22LATS21.51200284
23MAP3K91.46869428
24SGK31.46555874
25MAP2K41.41537255
26DAPK21.34644963
27PHKG11.29538276
28PHKG21.29538276
29BCR1.26056760
30PRKCG1.22613199
31CDK51.20469067
32TYRO31.14194838
33BMPR1B1.13856689
34KSR11.12809316
35CSNK1G21.11693302
36PAK61.11625259
37UHMK11.10899275
38CAMK1G1.09337463
39MAP4K21.03439319
40FRK1.01265832
41PKN11.00487789
42RPS6KA20.98433155
43LIMK10.95823020
44DAPK10.95526475
45PRKCE0.95513469
46MKNK10.94949126
47SIK20.94321579
48CAMK10.91906827
49TRIM280.91687256
50CAMK2A0.90888305
51ERBB40.90654215
52CAMK2B0.88452101
53TNIK0.86823860
54TSSK60.85309431
55CSNK1G30.84879729
56DYRK1A0.84376244
57TIE10.82551281
58OXSR10.81208914
59PRKCH0.80593583
60GRK50.77460725
61ADRBK20.73557297
62CSNK1A1L0.73366005
63PRKD30.71240403
64CAMKK20.68422768
65BRAF0.67408140
66BRSK10.65657709
67STK38L0.65204118
68PNCK0.64925750
69CDK190.64835356
70CDC70.64386505
71CCNB10.62717472
72ALK0.62256457
73SGK10.62070493
74ARAF0.61094193
75MARK20.61068925
76CAMK40.58088341
77CAMK1D0.57964926
78PRKCZ0.57399551
79CDK180.56926259
80GRK70.56716057
81RPS6KB10.55409690
82FGFR20.55399989
83PAK30.55315267
84BMPR20.55244804
85CSNK1E0.53297104
86CSNK1G10.53011170
87ADRBK10.52837313
88CAMK2G0.52744413
89CDK140.52684706
90MUSK0.51626185
91PLK30.50616108
92BRD40.50259377
93NTRK10.50159118
94CAMKK10.49983413
95EPHA30.49970667
96CSNK1D0.49546925
97STK390.47376803
98GRK10.47247540
99CDK150.46553735
100PDK40.45319184
101PDK30.45319184
102PINK10.45315427
103FGFR10.45223787
104ROCK20.44108734
105CSNK1A10.43051945
106MAP2K10.42991880
107INSRR0.41283187
108CAMK2D0.41092881
109FES0.40834744
110PRKDC0.40810193
111MKNK20.39517651
112NME10.39392825
113PRKCB0.38372583
114RPS6KA30.38298076
115ROCK10.38235320
116KSR20.38154273
117PLK40.37670461
118CDK30.37240727
119ERBB20.36044453
120PLK10.36014985
121MAPK80.35971728
122GSK3B0.35789120
123ZAK0.35762154
124CDK11A0.35070637
125NUAK10.34770988
126PRKACA0.34573530
127STK110.32925815
128PRKG10.32505873
129MAPK90.31901765
130WNK10.28344519
131MAPK100.26708962

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.05972787
2Synaptic vesicle cycle_Homo sapiens_hsa047213.66536689
3GABAergic synapse_Homo sapiens_hsa047272.97688529
4Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.81915708
5Morphine addiction_Homo sapiens_hsa050322.67327487
6Collecting duct acid secretion_Homo sapiens_hsa049662.66607337
7Olfactory transduction_Homo sapiens_hsa047402.56858718
8Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.48791687
9Circadian entrainment_Homo sapiens_hsa047132.43608648
10Glutamatergic synapse_Homo sapiens_hsa047242.38748075
11Dopaminergic synapse_Homo sapiens_hsa047282.28453301
12Long-term potentiation_Homo sapiens_hsa047202.05801397
13Serotonergic synapse_Homo sapiens_hsa047262.02183051
14Amphetamine addiction_Homo sapiens_hsa050312.01347696
15Taste transduction_Homo sapiens_hsa047422.01337963
16Vibrio cholerae infection_Homo sapiens_hsa051101.86952245
17Long-term depression_Homo sapiens_hsa047301.86416061
18Cholinergic synapse_Homo sapiens_hsa047251.84891711
19Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.79241366
20Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.77607035
21Cocaine addiction_Homo sapiens_hsa050301.77567785
22Insulin secretion_Homo sapiens_hsa049111.77502477
23Axon guidance_Homo sapiens_hsa043601.76019060
24Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.52611548
25Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.44157898
26Salivary secretion_Homo sapiens_hsa049701.38293208
27Renin secretion_Homo sapiens_hsa049241.35200030
28Aldosterone synthesis and secretion_Homo sapiens_hsa049251.29208517
29Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.28870352
30Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.24293403
31ErbB signaling pathway_Homo sapiens_hsa040121.21772707
32Gastric acid secretion_Homo sapiens_hsa049711.20494394
33Calcium signaling pathway_Homo sapiens_hsa040201.17401709
34Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.17390774
35Gap junction_Homo sapiens_hsa045401.16166201
36Butanoate metabolism_Homo sapiens_hsa006501.12883388
37Hippo signaling pathway_Homo sapiens_hsa043901.11126339
38Oxytocin signaling pathway_Homo sapiens_hsa049211.06682091
39Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.06639673
40Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.03126516
41Phototransduction_Homo sapiens_hsa047441.01064555
42Oxidative phosphorylation_Homo sapiens_hsa001901.00520387
43Type I diabetes mellitus_Homo sapiens_hsa049400.98825421
44Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.95704188
45Basal cell carcinoma_Homo sapiens_hsa052170.95214302
46Type II diabetes mellitus_Homo sapiens_hsa049300.94748330
47cAMP signaling pathway_Homo sapiens_hsa040240.93864046
48Dorso-ventral axis formation_Homo sapiens_hsa043200.93704076
49Vitamin B6 metabolism_Homo sapiens_hsa007500.91948769
50Melanogenesis_Homo sapiens_hsa049160.88003443
51GnRH signaling pathway_Homo sapiens_hsa049120.85723666
52Endometrial cancer_Homo sapiens_hsa052130.85141225
53Phagosome_Homo sapiens_hsa041450.82507705
54Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.82053051
55Circadian rhythm_Homo sapiens_hsa047100.80558465
56Glioma_Homo sapiens_hsa052140.80251550
57Phosphatidylinositol signaling system_Homo sapiens_hsa040700.79696508
58Estrogen signaling pathway_Homo sapiens_hsa049150.78069661
59Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.76792056
60Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.75457946
61SNARE interactions in vesicular transport_Homo sapiens_hsa041300.74891050
62Alzheimers disease_Homo sapiens_hsa050100.73501012
63Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.73375119
64Basal transcription factors_Homo sapiens_hsa030220.73264249
65Colorectal cancer_Homo sapiens_hsa052100.72612243
66Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.72301566
67Maturity onset diabetes of the young_Homo sapiens_hsa049500.72116866
68Alcoholism_Homo sapiens_hsa050340.72051836
69Parkinsons disease_Homo sapiens_hsa050120.71691317
70Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.70988687
71Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.70280348
72Rheumatoid arthritis_Homo sapiens_hsa053230.69074488
73Tight junction_Homo sapiens_hsa045300.69025008
74Ras signaling pathway_Homo sapiens_hsa040140.66696207
75cGMP-PKG signaling pathway_Homo sapiens_hsa040220.65149744
76MAPK signaling pathway_Homo sapiens_hsa040100.63049367
77Vascular smooth muscle contraction_Homo sapiens_hsa042700.60787583
78Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.59979740
79Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.57588722
80Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.57431417
81Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.56513786
82Oocyte meiosis_Homo sapiens_hsa041140.56206466
83Ovarian steroidogenesis_Homo sapiens_hsa049130.54542941
84mRNA surveillance pathway_Homo sapiens_hsa030150.52638819
85Wnt signaling pathway_Homo sapiens_hsa043100.51804719
86RNA degradation_Homo sapiens_hsa030180.51125316
87Regulation of autophagy_Homo sapiens_hsa041400.50765431
88Inositol phosphate metabolism_Homo sapiens_hsa005620.50695153
89TGF-beta signaling pathway_Homo sapiens_hsa043500.50578545
90Neurotrophin signaling pathway_Homo sapiens_hsa047220.48908853
91Melanoma_Homo sapiens_hsa052180.48428336
92Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.48324616
93Renal cell carcinoma_Homo sapiens_hsa052110.48257976
94Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.47661921
95Cardiac muscle contraction_Homo sapiens_hsa042600.46895316
96Huntingtons disease_Homo sapiens_hsa050160.43793891
97Bile secretion_Homo sapiens_hsa049760.43339830
98Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.40594179
99Choline metabolism in cancer_Homo sapiens_hsa052310.39276371
100Rap1 signaling pathway_Homo sapiens_hsa040150.38977031
101Glucagon signaling pathway_Homo sapiens_hsa049220.37916782
102Adherens junction_Homo sapiens_hsa045200.37835880
103Protein digestion and absorption_Homo sapiens_hsa049740.37794834
104Hedgehog signaling pathway_Homo sapiens_hsa043400.37688811
105Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.36762083
106Steroid biosynthesis_Homo sapiens_hsa001000.36418945
107Thyroid hormone synthesis_Homo sapiens_hsa049180.35791232
108Insulin signaling pathway_Homo sapiens_hsa049100.34643663
109Selenocompound metabolism_Homo sapiens_hsa004500.34485602
110Dilated cardiomyopathy_Homo sapiens_hsa054140.34450972
111Fatty acid biosynthesis_Homo sapiens_hsa000610.33666924
112Nitrogen metabolism_Homo sapiens_hsa009100.33502238
113beta-Alanine metabolism_Homo sapiens_hsa004100.32836800
114Carbohydrate digestion and absorption_Homo sapiens_hsa049730.30432033
115Endocytosis_Homo sapiens_hsa041440.30423373
116Protein export_Homo sapiens_hsa030600.29326632
117Pancreatic secretion_Homo sapiens_hsa049720.28639873
118Longevity regulating pathway - mammal_Homo sapiens_hsa042110.28479546
119Chemokine signaling pathway_Homo sapiens_hsa040620.28183363
120Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.27743311
121Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.27539231
122Thyroid hormone signaling pathway_Homo sapiens_hsa049190.27079657
123Ether lipid metabolism_Homo sapiens_hsa005650.27035216
124Sphingolipid signaling pathway_Homo sapiens_hsa040710.26501919
125Phospholipase D signaling pathway_Homo sapiens_hsa040720.26261921

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