INPP5J

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1thyroid hormone metabolic process (GO:0042403)9.40378913
2NADH metabolic process (GO:0006734)5.82584474
3locomotory exploration behavior (GO:0035641)5.79914278
4sulfate transmembrane transport (GO:1902358)5.67675686
5synaptic vesicle maturation (GO:0016188)5.55504175
6thyroid gland development (GO:0030878)5.47406754
7regulation of short-term neuronal synaptic plasticity (GO:0048172)5.33765749
8positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.12672470
9positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.07104751
10vocalization behavior (GO:0071625)4.90296464
11synaptic vesicle exocytosis (GO:0016079)4.74572454
12response to parathyroid hormone (GO:0071107)4.72391563
13sulfate transport (GO:0008272)4.66283831
14regulation of synapse structural plasticity (GO:0051823)4.62491803
15neuronal action potential propagation (GO:0019227)4.62181696
16glutamate secretion (GO:0014047)4.55101853
17angiotensin maturation (GO:0002003)4.53893071
18sodium ion export (GO:0071436)4.51625439
19cellular potassium ion homeostasis (GO:0030007)4.49908148
20cell communication by electrical coupling involved in cardiac conduction (GO:0086064)4.43344131
21synaptic vesicle docking involved in exocytosis (GO:0016081)4.36392034
22regulation of synaptic vesicle exocytosis (GO:2000300)4.34434273
23regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.32378637
24membrane repolarization during action potential (GO:0086011)4.29933600
25neurotransmitter secretion (GO:0007269)4.29223650
26membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.29176549
27ionotropic glutamate receptor signaling pathway (GO:0035235)4.27026561
28cytoskeletal anchoring at plasma membrane (GO:0007016)4.08566698
29exploration behavior (GO:0035640)4.07710398
30regulation of glutamate receptor signaling pathway (GO:1900449)4.04771096
31positive regulation of cellular amine metabolic process (GO:0033240)4.00448106
32gamma-aminobutyric acid transport (GO:0015812)3.99259423
33cell communication by electrical coupling (GO:0010644)3.98016405
34glutamate receptor signaling pathway (GO:0007215)3.89544278
35regulation of synaptic vesicle transport (GO:1902803)3.88495872
36regulation of neuronal synaptic plasticity (GO:0048168)3.86879417
37synaptic transmission, glutamatergic (GO:0035249)3.85761045
38regulation of long-term neuronal synaptic plasticity (GO:0048169)3.85011244
39cerebellar Purkinje cell differentiation (GO:0021702)3.81268071
40fructose metabolic process (GO:0006000)3.70055804
41long-term memory (GO:0007616)3.68520019
42regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)3.65730612
43neuromuscular process controlling posture (GO:0050884)3.64697408
44positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.61044121
45neuron-neuron synaptic transmission (GO:0007270)3.60992577
46potassium ion import (GO:0010107)3.58198375
47regulation of voltage-gated calcium channel activity (GO:1901385)3.54474276
48positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.53039546
49glycine transport (GO:0015816)3.52842055
50protein localization to synapse (GO:0035418)3.51707082
51cerebellar granule cell differentiation (GO:0021707)3.50413415
52cellular sodium ion homeostasis (GO:0006883)3.49987356
53regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.48265434
54positive regulation of membrane potential (GO:0045838)3.47205822
55layer formation in cerebral cortex (GO:0021819)3.46245518
56membrane depolarization during action potential (GO:0086010)3.44227071
57neuromuscular process controlling balance (GO:0050885)3.43417515
58neurotransmitter transport (GO:0006836)3.42208003
59activation of protein kinase A activity (GO:0034199)3.41965103
60cell communication involved in cardiac conduction (GO:0086065)3.40550818
61regulation of excitatory postsynaptic membrane potential (GO:0060079)3.39910377
62neurotransmitter-gated ion channel clustering (GO:0072578)3.38752164
63G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.37921912
64membrane hyperpolarization (GO:0060081)3.35086500
65regulation of guanylate cyclase activity (GO:0031282)3.33617448
66positive regulation of synapse maturation (GO:0090129)3.32879428
67regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.32295624
68dendritic spine morphogenesis (GO:0060997)3.27202879
69response to pheromone (GO:0019236)3.26399200
70regulation of postsynaptic membrane potential (GO:0060078)3.22497584
71regulation of neurotransmitter levels (GO:0001505)3.21874265
72potassium ion homeostasis (GO:0055075)3.21131582
73positive regulation of potassium ion transmembrane transport (GO:1901381)3.19507294
74regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.19136281
75sodium ion homeostasis (GO:0055078)3.17463943
76ventricular cardiac muscle cell action potential (GO:0086005)3.17114903
77proline transport (GO:0015824)3.16461155
78membrane repolarization (GO:0086009)3.16381173
79regulation of synaptic plasticity (GO:0048167)3.12623100
80auditory behavior (GO:0031223)3.12290896
81neuron cell-cell adhesion (GO:0007158)3.12040161
82transmission of nerve impulse (GO:0019226)3.11724328
83receptor recycling (GO:0001881)3.10401586
84regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)3.05353021
85myelin maintenance (GO:0043217)3.04424064
86proline biosynthetic process (GO:0006561)3.04116614
87prepulse inhibition (GO:0060134)3.03825592
88protein retention in ER lumen (GO:0006621)3.03681208
89behavioral response to cocaine (GO:0048148)3.03220120
90membrane depolarization (GO:0051899)3.02396756
91gamma-aminobutyric acid signaling pathway (GO:0007214)3.00271571
92membrane repolarization during cardiac muscle cell action potential (GO:0086013)3.00260777
93regulation of dendritic spine morphogenesis (GO:0061001)2.99884420
94regulation of neurotransmitter secretion (GO:0046928)2.97490217
95long-term synaptic potentiation (GO:0060291)2.96345374
96sulfur compound transport (GO:0072348)2.95672533
97neuronal ion channel clustering (GO:0045161)2.95190215
98regulation of apoptotic process involved in morphogenesis (GO:1902337)2.93478248
99regulation of ARF protein signal transduction (GO:0032012)2.93387043
100chemosensory behavior (GO:0007635)2.93077227
101response to auditory stimulus (GO:0010996)2.89357888
102regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.88283151
103cell differentiation in hindbrain (GO:0021533)2.87796064
104regulation of membrane repolarization (GO:0060306)2.87654608
105regulation of synaptic transmission, glutamatergic (GO:0051966)2.87409976
106response to hepatocyte growth factor (GO:0035728)2.87350312
107cellular response to hepatocyte growth factor stimulus (GO:0035729)2.87350312
108positive regulation of potassium ion transport (GO:0043268)2.86329982
109dendrite morphogenesis (GO:0048813)2.86169201
110adult walking behavior (GO:0007628)2.85982088
111synaptic vesicle endocytosis (GO:0048488)2.84748648
112negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.81873104
113neuromuscular process (GO:0050905)2.81476319
114regulation of neurotransmitter transport (GO:0051588)2.80771884
115regulation of calcium ion transmembrane transport (GO:1903169)2.80493115
116regulation of calcium ion transmembrane transporter activity (GO:1901019)2.80493115
117positive regulation of sodium ion transport (GO:0010765)2.80203638
118positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.79996681
119detection of calcium ion (GO:0005513)2.79617159
120long term synaptic depression (GO:0060292)2.79406235
121negative regulation of synaptic transmission, GABAergic (GO:0032229)2.78697368
122maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.78429373
123receptor guanylyl cyclase signaling pathway (GO:0007168)2.77788604
124regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.76561959
125regulation of vesicle fusion (GO:0031338)2.76357791
126negative regulation of hormone biosynthetic process (GO:0032353)2.75986966
127regulation of synapse maturation (GO:0090128)2.73198925
128relaxation of cardiac muscle (GO:0055119)2.71414824
129negative regulation of hormone metabolic process (GO:0032351)2.67391411
130bundle of His cell to Purkinje myocyte communication (GO:0086069)2.66915347
131trivalent inorganic anion homeostasis (GO:0072506)2.66043500
132phosphate ion homeostasis (GO:0055062)2.66043500
133phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)2.62970372
134cardiac conduction (GO:0061337)2.61568946
135actin filament depolymerization (GO:0030042)2.60127587
136epithelial cell-cell adhesion (GO:0090136)2.60003507
137glutamine family amino acid biosynthetic process (GO:0009084)2.59487540
138cardiac muscle contraction (GO:0060048)2.58344002
139cellular response to gonadotropin stimulus (GO:0071371)2.54286558
140dendritic spine organization (GO:0097061)2.54089995
141regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)2.54079041
142endocrine process (GO:0050886)2.54079041
143regulation of systemic arterial blood pressure by hormone (GO:0001990)2.54079041
144proline metabolic process (GO:0006560)2.53627156
145oxaloacetate metabolic process (GO:0006107)2.53158927
146Golgi transport vesicle coating (GO:0048200)2.51477075
147COPI coating of Golgi vesicle (GO:0048205)2.51477075
148retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.51339897
149urea cycle (GO:0000050)2.51316647
150regulation of cholesterol metabolic process (GO:0090181)2.51074858
151renal system process involved in regulation of blood volume (GO:0001977)2.50814445
152dopamine receptor signaling pathway (GO:0007212)2.50561754
153positive regulation of glucose import (GO:0046326)2.49574980
154positive regulation of glycogen biosynthetic process (GO:0045725)2.48796764
155hydrogen peroxide catabolic process (GO:0042744)2.47682796
156regulation of heart rate by cardiac conduction (GO:0086091)2.44264643
157regulation of bile acid biosynthetic process (GO:0070857)2.43844006
158negative regulation of cell size (GO:0045792)2.43510377
159positive regulation of hormone metabolic process (GO:0032352)2.42548357
160regulation of systemic arterial blood pressure (GO:0003073)2.41989418
161metanephric tubule development (GO:0072170)2.41855044
162metanephric nephron tubule development (GO:0072234)2.41855044
163response to lead ion (GO:0010288)2.41732950
164adenine nucleotide transport (GO:0051503)2.41483770
165regulation of glucose import in response to insulin stimulus (GO:2001273)2.41084667
166desmosome organization (GO:0002934)2.40894489
167peptidyl-tyrosine autophosphorylation (GO:0038083)2.40607237
168gluconeogenesis (GO:0006094)2.40604545
169cell-cell junction maintenance (GO:0045217)2.39303091
170metanephric nephron epithelium development (GO:0072243)2.39147322
171thyroid hormone generation (GO:0006590)11.5343899

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.38592639
2SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.09235573
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.93535426
4DROSHA_22980978_ChIP-Seq_HELA_Human2.89636632
5JARID2_20064375_ChIP-Seq_MESCs_Mouse2.80439664
6TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.72567486
7RNF2_18974828_ChIP-Seq_MESCs_Mouse2.72316988
8EZH2_18974828_ChIP-Seq_MESCs_Mouse2.72316988
9RARB_27405468_Chip-Seq_BRAIN_Mouse2.66154163
10MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.59852323
11JARID2_20075857_ChIP-Seq_MESCs_Mouse2.59785802
12GBX2_23144817_ChIP-Seq_PC3_Human2.56508903
13MTF2_20144788_ChIP-Seq_MESCs_Mouse2.56477040
14* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.51137123
15REST_21632747_ChIP-Seq_MESCs_Mouse2.50685057
16RACK7_27058665_Chip-Seq_MCF-7_Human2.46249561
17SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.44585263
18SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.41407605
19IKZF1_21737484_ChIP-ChIP_HCT116_Human2.35458251
20EZH2_27294783_Chip-Seq_ESCs_Mouse2.32632159
21SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.31210412
22EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.28243470
23* SUZ12_27294783_Chip-Seq_ESCs_Mouse2.24612179
24EZH2_27304074_Chip-Seq_ESCs_Mouse2.17295425
25REST_18959480_ChIP-ChIP_MESCs_Mouse2.13235225
26ZNF263_19887448_ChIP-Seq_K562_Human2.12222894
27RNF2_27304074_Chip-Seq_ESCs_Mouse2.10278446
28ESR1_21235772_ChIP-Seq_MCF-7_Human2.09117589
29PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.06340559
30EED_16625203_ChIP-ChIP_MESCs_Mouse2.05181424
31CREB1_26743006_Chip-Seq_LNCaP_Human1.88039180
32* TET1_21451524_ChIP-Seq_MESCs_Mouse1.83713500
33ERG_21242973_ChIP-ChIP_JURKAT_Human1.81886138
34ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.81653652
35NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.78208580
36P68_20966046_ChIP-Seq_HELA_Human1.76571576
37CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.69745758
38CDX2_20551321_ChIP-Seq_CACO-2_Human1.68175841
39CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.64147109
40RARG_19884340_ChIP-ChIP_MEFs_Mouse1.56661094
41* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.56452157
42SRY_22984422_ChIP-ChIP_TESTIS_Rat1.52257844
43RUNX1_27514584_Chip-Seq_MCF-7_Human1.51169167
44ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.50060120
45TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.48716992
46DNAJC2_21179169_ChIP-ChIP_NT2_Human1.48091095
47KDM2B_26808549_Chip-Seq_K562_Human1.42375360
48ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.38766027
49CLOCK_20551151_ChIP-Seq_293T_Human1.37544705
50KDM2B_26808549_Chip-Seq_DND41_Human1.37522967
51UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.36365896
52ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.35689980
53KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.35191357
54AR_21572438_ChIP-Seq_LNCaP_Human1.34465025
55NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.33013786
56SA1_27219007_Chip-Seq_ERYTHROID_Human1.31756221
57SMAD4_21799915_ChIP-Seq_A2780_Human1.31744324
58RING1B_27294783_Chip-Seq_ESCs_Mouse1.30538862
59ZNF274_21170338_ChIP-Seq_K562_Hela1.30265673
60RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.29980474
61SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.29933108
62TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.29444071
63SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.28343145
64WT1_25993318_ChIP-Seq_PODOCYTE_Human1.28119163
65EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.27487139
66CTCF_27219007_Chip-Seq_ERYTHROID_Human1.25916939
67* SOX2_27498859_Chip-Seq_STOMACH_Mouse1.25738685
68THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.24953825
69KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.23886026
70GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.22441832
71GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.21965091
72TCF7_22412390_ChIP-Seq_EML_Mouse1.19844984
73NR3C1_23031785_ChIP-Seq_PC12_Mouse1.18568450
74AR_19668381_ChIP-Seq_PC3_Human1.18521323
75CDX2_19796622_ChIP-Seq_MESCs_Mouse1.18470407
76ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.16867321
77SOX2_21211035_ChIP-Seq_LN229_Gbm1.16812217
78CTBP2_25329375_ChIP-Seq_LNCAP_Human1.16782177
79CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.15708250
80ESR1_15608294_ChIP-ChIP_MCF-7_Human1.13986771
81ZFP281_18757296_ChIP-ChIP_E14_Mouse1.13335887
82JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse1.12851787
83ELK3_25401928_ChIP-Seq_HUVEC_Human1.12657907
84WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.12488085
85* TP63_22573176_ChIP-Seq_HFKS_Human1.12475091
86ZNF217_24962896_ChIP-Seq_MCF-7_Human1.11516841
87* PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.10953929
88SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.10877127
89OCT4_19829295_ChIP-Seq_ESCs_Human1.10390960
90PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.09437816
91SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.08272343
92PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.07243701
93AHR_22903824_ChIP-Seq_MCF-7_Human1.06556286
94PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.06277091
95FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.06179946
96BCOR_27268052_Chip-Seq_Bcells_Human1.06113198
97MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.05769889
98RXR_22158963_ChIP-Seq_LIVER_Mouse1.04552718
99SA1_27219007_Chip-Seq_Bcells_Human1.03597473
100CTCF_27219007_Chip-Seq_Bcells_Human1.03213796
101KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.02759962
102EP300_21415370_ChIP-Seq_HL-1_Mouse1.02563323
103ESR2_21235772_ChIP-Seq_MCF-7_Human1.02111706
104P300_27058665_Chip-Seq_ZR-75-30cells_Human1.01824247
105PPARA_22158963_ChIP-Seq_LIVER_Mouse1.01325694
106TET1_21490601_ChIP-Seq_MESCs_Mouse1.00887225
107ARNT_22903824_ChIP-Seq_MCF-7_Human1.00142658
108TP63_17297297_ChIP-ChIP_HaCaT_Human1.00034209
109RING1B_27294783_Chip-Seq_NPCs_Mouse0.99875720
110CTBP1_25329375_ChIP-Seq_LNCAP_Human0.99440476
111SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.99325201
112STAT3_23295773_ChIP-Seq_U87_Human0.99302855
113VDR_21846776_ChIP-Seq_THP-1_Human0.98812574
114PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.98706535
115RARA_24833708_ChIP-Seq_LIVER_Mouse0.98319299
116CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.96686906
117P53_22127205_ChIP-Seq_FIBROBLAST_Human0.96589145
118AR_25329375_ChIP-Seq_VCAP_Human0.95338189
119SMAD3_21741376_ChIP-Seq_HESCs_Human0.95072203
120SMAD4_21741376_ChIP-Seq_HESCs_Human0.94609178
121TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.93746813
122SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.92898758
123RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.92499960
124KDM2B_26808549_Chip-Seq_SUP-B15_Human0.92422488
125SMAD3_21741376_ChIP-Seq_EPCs_Human0.91420572
126LXR_22292898_ChIP-Seq_THP-1_Human0.88555477
127PIAS1_25552417_ChIP-Seq_VCAP_Human0.88090292
128RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.87886653
129ESR1_20079471_ChIP-ChIP_T-47D_Human0.87323374
130ZFP281_27345836_Chip-Seq_ESCs_Mouse0.87248196
131RXR_22108803_ChIP-Seq_LS180_Human0.86699000
132YAP1_20516196_ChIP-Seq_MESCs_Mouse0.86511881
133TCF4_23295773_ChIP-Seq_U87_Human0.86199146
134TOP2B_26459242_ChIP-Seq_MCF-7_Human0.85230172
135ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.84735641
136KLF4_19829295_ChIP-Seq_ESCs_Human0.84361628
137MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.84194538
138SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.84104786
139CTNNB1_20460455_ChIP-Seq_HCT116_Human0.83545724
140SMAD3_21741376_ChIP-Seq_ESCs_Human0.83380057
141VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.83326350
142BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.82910939
143TAF15_26573619_Chip-Seq_HEK293_Human0.82688867
144OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.81779604
145SMC4_20622854_ChIP-Seq_HELA_Human0.81588436
146SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.80981655
147NR3C1_21868756_ChIP-Seq_MCF10A_Human0.80823318
148TP53_16413492_ChIP-PET_HCT116_Human0.80142108
149SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.77548611
150DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.76921832

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000678_abnormal_parathyroid_gland6.25019852
2MP0004859_abnormal_synaptic_plasticity6.22226730
3MP0000681_abnormal_thyroid_gland5.34178131
4MP0003635_abnormal_synaptic_transmissio3.88223440
5MP0003880_abnormal_central_pattern3.62807997
6MP0004270_analgesia3.47002772
7MP0009046_muscle_twitch3.43339071
8MP0005360_urolithiasis3.37545983
9MP0002876_abnormal_thyroid_physiology3.37498189
10MP0009745_abnormal_behavioral_response3.20617166
11MP0002822_catalepsy3.11008794
12MP0002064_seizures3.00400002
13MP0002063_abnormal_learning/memory/cond2.94405910
14MP0002272_abnormal_nervous_system2.72542560
15MP0002572_abnormal_emotion/affect_behav2.48959562
16MP0001486_abnormal_startle_reflex2.47340258
17MP0001968_abnormal_touch/_nociception2.46737971
18MP0002734_abnormal_mechanical_nocicepti2.46105192
19MP0008569_lethality_at_weaning2.45012470
20MP0004264_abnormal_extraembryonic_tissu2.43506306
21MP0005423_abnormal_somatic_nervous2.39832488
22MP0003183_abnormal_peptide_metabolism2.30048796
23MP0003879_abnormal_hair_cell2.20918997
24MP0005409_darkened_coat_color2.19455143
25MP0002735_abnormal_chemical_nociception2.14620525
26MP0001501_abnormal_sleep_pattern2.11629297
27MP0002909_abnormal_adrenal_gland2.10307111
28MP0001666_abnormal_nutrient_absorption2.01089504
29MP0001440_abnormal_grooming_behavior1.99726918
30MP0002067_abnormal_sensory_capabilities1.97097230
31MP0003329_amyloid_beta_deposits1.91382280
32MP0002736_abnormal_nociception_after1.91002747
33MP0009780_abnormal_chondrocyte_physiolo1.90590903
34MP0004885_abnormal_endolymph1.85447498
35MP0000751_myopathy1.85238855
36MP0001970_abnormal_pain_threshold1.83619809
37MP0002837_dystrophic_cardiac_calcinosis1.80836805
38MP0002733_abnormal_thermal_nociception1.80820408
39MP0004858_abnormal_nervous_system1.80638757
40MP0000383_abnormal_hair_follicle1.76208349
41MP0004043_abnormal_pH_regulation1.72467188
42MP0002249_abnormal_larynx_morphology1.71089257
43MP0001188_hyperpigmentation1.69899695
44MP0004019_abnormal_vitamin_homeostasis1.69197395
45MP0002184_abnormal_innervation1.68647399
46MP0010678_abnormal_skin_adnexa1.68467927
47MP0004145_abnormal_muscle_electrophysio1.67653828
48MP0002796_impaired_skin_barrier1.62516662
49MP0004215_abnormal_myocardial_fiber1.62133180
50MP0004924_abnormal_behavior1.59995272
51MP0005386_behavior/neurological_phenoty1.59995272
52MP0004811_abnormal_neuron_physiology1.53788688
53MP0002557_abnormal_social/conspecific_i1.52906577
54MP0001485_abnormal_pinna_reflex1.40179262
55MP0002066_abnormal_motor_capabilities/c1.39327661
56MP0000955_abnormal_spinal_cord1.39159083
57MP0003633_abnormal_nervous_system1.38430745
58MP0009643_abnormal_urine_homeostasis1.37997500
59MP0000566_synostosis1.36435359
60MP0000537_abnormal_urethra_morphology1.36399821
61MP0001984_abnormal_olfaction1.34972828
62MP0003705_abnormal_hypodermis_morpholog1.34836533
63MP0003646_muscle_fatigue1.33028147
64MP0004142_abnormal_muscle_tone1.32184340
65MP0005365_abnormal_bile_salt1.30898968
66MP0000462_abnormal_digestive_system1.26920270
67MP0000778_abnormal_nervous_system1.26878564
68MP0002882_abnormal_neuron_morphology1.26752626
69MP0003283_abnormal_digestive_organ1.26666760
70MP0003137_abnormal_impulse_conducting1.26360173
71MP0009379_abnormal_foot_pigmentation1.26198438
72MP0005646_abnormal_pituitary_gland1.26082294
73MP0002098_abnormal_vibrissa_morphology1.23564420
74MP0005501_abnormal_skin_physiology1.21625199
75MP0009840_abnormal_foam_cell1.20560262
76MP0004085_abnormal_heartbeat1.19618216
77MP0005670_abnormal_white_adipose1.14231858
78MP0003631_nervous_system_phenotype1.13215919
79MP0006276_abnormal_autonomic_nervous1.11517774
80MP0002229_neurodegeneration1.10939424
81MP0003868_abnormal_feces_composition1.10434093
82MP0003938_abnormal_ear_development1.09698742
83MP0001502_abnormal_circadian_rhythm1.09596000
84MP0008872_abnormal_physiological_respon1.07395783
85MP0004484_altered_response_of1.07223671
86MP0000013_abnormal_adipose_tissue1.05083711
87MP0001849_ear_inflammation1.04755917
88MP0008004_abnormal_stomach_pH1.04047224
89MP0004036_abnormal_muscle_relaxation1.03132513
90MP0001963_abnormal_hearing_physiology1.02574506
91MP0000920_abnormal_myelination1.02177334
92MP0004742_abnormal_vestibular_system1.01382157
93MP0004782_abnormal_surfactant_physiolog1.00578306
94MP0001346_abnormal_lacrimal_gland0.99982089
95MP0005666_abnormal_adipose_tissue0.98903094
96MP0004084_abnormal_cardiac_muscle0.98527502
97MP0003690_abnormal_glial_cell0.98221393
98MP0001756_abnormal_urination0.97226529
99MP0002896_abnormal_bone_mineralization0.96554448
100MP0008961_abnormal_basal_metabolism0.95326304
101MP0005636_abnormal_mineral_homeostasis0.95087985
102MP0005367_renal/urinary_system_phenotyp0.93333470
103MP0000516_abnormal_urinary_system0.93333470
104MP0004510_myositis0.93001677
105MP0003787_abnormal_imprinting0.91865551
106MP0003075_altered_response_to0.91797747
107MP0010234_abnormal_vibrissa_follicle0.90406071
108MP0008874_decreased_physiological_sensi0.90404113
109MP0002152_abnormal_brain_morphology0.89733761
110MP0002069_abnormal_eating/drinking_beha0.89645999
111MP0005645_abnormal_hypothalamus_physiol0.89350496
112MP0005167_abnormal_blood-brain_barrier0.89075664
113MP0003878_abnormal_ear_physiology0.86421842
114MP0005377_hearing/vestibular/ear_phenot0.86421842
115MP0005535_abnormal_body_temperature0.85514377
116MP0001765_abnormal_ion_homeostasis0.85395561
117MP0003632_abnormal_nervous_system0.85186849
118MP0004233_abnormal_muscle_weight0.85165459
119MP0001905_abnormal_dopamine_level0.82737197
120MP0000747_muscle_weakness0.82235782
121MP0005076_abnormal_cell_differentiation0.81635186
122MP0003634_abnormal_glial_cell0.81337158
123MP0000749_muscle_degeneration0.79362708
124MP0000604_amyloidosis0.79191765
125MP0005330_cardiomyopathy0.78520210
126MP0005085_abnormal_gallbladder_physiolo0.78208794
127MP0001529_abnormal_vocalization0.77358540
128MP0002972_abnormal_cardiac_muscle0.77079531
129MP0006138_congestive_heart_failure0.77000164
130MP0000026_abnormal_inner_ear0.76391789
131MP0005620_abnormal_muscle_contractility0.76235846
132MP0005332_abnormal_amino_acid0.75102996
133MP0002234_abnormal_pharynx_morphology0.74448204
134MP0005375_adipose_tissue_phenotype0.73089714
135MP0001348_abnormal_lacrimal_gland0.72487513
136MP0005551_abnormal_eye_electrophysiolog0.71976590
137MP0004147_increased_porphyrin_level0.71591042
138MP0001664_abnormal_digestion0.71411107
139MP0002089_abnormal_postnatal_growth/wei0.69874822
140MP0003953_abnormal_hormone_level0.68867472
141MP0005451_abnormal_body_composition0.68580912
142MP0001177_atelectasis0.67216628
143MP0002752_abnormal_somatic_nervous0.65563008
144MP0000579_abnormal_nail_morphology0.65398810
145MP0004130_abnormal_muscle_cell0.64549089
146MP0000003_abnormal_adipose_tissue0.64183198
147MP0005166_decreased_susceptibility_to0.63471168
148MP0005584_abnormal_enzyme/coenzyme_acti0.63383924
149MP0005187_abnormal_penis_morphology0.61810039
150MP0005058_abnormal_lysosome_morphology0.61384461
151MP0004087_abnormal_muscle_fiber0.61018441
152MP0001299_abnormal_eye_distance/0.60930480
153MP0004185_abnormal_adipocyte_glucose0.60103805
154MP0003045_fibrosis0.59897411
155MP0000534_abnormal_ureter_morphology0.55487577
156MP0003123_paternal_imprinting0.55052905
157MP0010352_gastrointestinal_tract_polyps0.55017397
158MP0000538_abnormal_urinary_bladder0.54109951

Predicted human phenotypes

RankGene SetZ-score
1Goiter (HP:0000853)7.38046713
2Myokymia (HP:0002411)6.66875957
3Focal motor seizures (HP:0011153)6.45295779
4Hyperphosphatemia (HP:0002905)6.17601026
5Thyroid-stimulating hormone excess (HP:0002925)5.98434414
6Pili torti (HP:0003777)5.63740615
7Tetany (HP:0001281)5.29919454
8Visual hallucinations (HP:0002367)5.16078546
9Focal seizures (HP:0007359)5.14734554
10Hyperparathyroidism (HP:0000843)5.02366012
11Action tremor (HP:0002345)4.92905556
12Progressive cerebellar ataxia (HP:0002073)4.67945677
13Hyperthyroidism (HP:0000836)4.55358363
14Aplasia/Hypoplasia of the abdominal wall musculature (HP:0010318)4.47527571
15Congenital sensorineural hearing impairment (HP:0008527)4.26312212
16Delayed epiphyseal ossification (HP:0002663)4.10709932
17Atonic seizures (HP:0010819)4.08413540
18Febrile seizures (HP:0002373)3.94685904
19Ventricular fibrillation (HP:0001663)3.94588650
20Epileptic encephalopathy (HP:0200134)3.86899750
21Abnormality of glutamine family amino acid metabolism (HP:0010902)3.80341013
22Abnormality of cochlea (HP:0000375)3.69992641
23Gaze-evoked nystagmus (HP:0000640)3.58182646
24Absence seizures (HP:0002121)3.57212439
25Bundle branch block (HP:0011710)3.43993729
26Dysmetric saccades (HP:0000641)3.43875271
27Dysdiadochokinesis (HP:0002075)3.43199539
28Supranuclear gaze palsy (HP:0000605)3.41984670
29Abnormal hair laboratory examination (HP:0003328)3.39207524
30Generalized tonic-clonic seizures (HP:0002069)3.38086874
31Dysmetria (HP:0001310)3.31420829
32Hypoparathyroidism (HP:0000829)3.21997440
33Dialeptic seizures (HP:0011146)3.14359417
34Depression (HP:0000716)3.12695837
35Abnormality of calcium-phosphate metabolism (HP:0100530)3.10594454
36Broad-based gait (HP:0002136)3.10241837
37Morphological abnormality of the inner ear (HP:0011390)3.07035645
38Scanning speech (HP:0002168)3.06884464
39Poor eye contact (HP:0000817)3.06157195
40Anxiety (HP:0000739)3.01567093
41Ankle clonus (HP:0011448)3.01220666
42Abnormal social behavior (HP:0012433)2.99478017
43Impaired social interactions (HP:0000735)2.99478017
44Genetic anticipation (HP:0003743)2.99374817
45Hemiplegia (HP:0002301)2.99153445
46Small epiphyses (HP:0010585)2.97631227
47Impaired vibration sensation in the lower limbs (HP:0002166)2.97057960
48Prolonged QT interval (HP:0001657)2.90944812
49Impaired smooth pursuit (HP:0007772)2.86101920
50Truncal ataxia (HP:0002078)2.85997793
51Postural instability (HP:0002172)2.85319239
52Abnormality of the lower motor neuron (HP:0002366)2.85286403
53Intention tremor (HP:0002080)2.83206265
54Abnormal eating behavior (HP:0100738)2.80380376
55Hypocalcemia (HP:0002901)2.80282327
56Sudden death (HP:0001699)2.79635886
57Alacrima (HP:0000522)2.77815179
58Thin bony cortex (HP:0002753)2.76398369
59Syncope (HP:0001279)2.75200891
60Hydroxyprolinuria (HP:0003080)2.70715428
61Abnormality of proline metabolism (HP:0010907)2.70715428
62Pheochromocytoma (HP:0002666)2.61201337
63Urinary bladder sphincter dysfunction (HP:0002839)2.61198918
64Abnormal EKG (HP:0003115)2.60573222
65J-shaped sella turcica (HP:0002680)2.60525799
66Malnutrition (HP:0004395)2.57899306
67Metabolic alkalosis (HP:0200114)2.52312090
68Annular pancreas (HP:0001734)2.52286965
69Right ventricular cardiomyopathy (HP:0011663)2.52108908
70Abnormality of binocular vision (HP:0011514)2.49556464
71Diplopia (HP:0000651)2.49556464
72Obstructive sleep apnea (HP:0002870)2.46596374
73Thyroid carcinoma (HP:0002890)2.46410652
74Abnormality of ocular smooth pursuit (HP:0000617)2.45721026
75Urinary urgency (HP:0000012)2.43332043
76Bronchomalacia (HP:0002780)2.42125406
77Increased circulating renin level (HP:0000848)2.41143779
78Hypothyroidism (HP:0000821)2.39713242
79Torticollis (HP:0000473)2.37985421
80Hemiparesis (HP:0001269)2.37971408
81Spastic gait (HP:0002064)2.34077476
82Hyperpituitarism (HP:0010514)2.32847846
83Status epilepticus (HP:0002133)2.31129584
84Widely patent fontanelles and sutures (HP:0004492)2.26940592
85Mutism (HP:0002300)2.26637393
86Atrial fibrillation (HP:0005110)2.25927248
87Abnormality of saccadic eye movements (HP:0000570)2.25895916
88Microretrognathia (HP:0000308)2.25530744
89Exercise-induced myalgia (HP:0003738)2.24536662
90Abdominal distention (HP:0003270)2.23825952
91Stereotypic behavior (HP:0000733)2.22574591
92Heart block (HP:0012722)2.22207657
93Athetosis (HP:0002305)2.20599940
94Primary atrial arrhythmia (HP:0001692)2.18243145
95Focal dystonia (HP:0004373)2.17703156
96Ventricular arrhythmia (HP:0004308)2.17335582
97Hypercortisolism (HP:0001578)2.17237717
98Neuroendocrine neoplasm (HP:0100634)2.15995563
99Preauricular pit (HP:0004467)2.14512642
100Periauricular skin pits (HP:0100277)2.14512642
101Myotonia (HP:0002486)2.11747153
102Bradykinesia (HP:0002067)2.07579353
103Hyperglycinuria (HP:0003108)2.06440329
104Lower limb asymmetry (HP:0100559)2.05825250
105Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.04510286
106Hyperventilation (HP:0002883)2.04402002
107Decreased circulating renin level (HP:0003351)2.04127471
108Supraventricular tachycardia (HP:0004755)2.03165962
109Epileptiform EEG discharges (HP:0011182)2.02862800
110Abnormality of the corticospinal tract (HP:0002492)2.02817795
111Growth hormone excess (HP:0000845)2.00335110
112Abnormal atrioventricular conduction (HP:0005150)1.99808809
113Impaired vibratory sensation (HP:0002495)1.99142975
114Pointed chin (HP:0000307)1.98945788
115Distal lower limb muscle weakness (HP:0009053)1.98380202
116EEG with generalized epileptiform discharges (HP:0011198)1.98294518
117Abnormality of magnesium homeostasis (HP:0004921)1.97000557
118Decreased lacrimation (HP:0000633)1.96525423
119Hyperacusis (HP:0010780)1.96510312
120Supraventricular arrhythmia (HP:0005115)1.95791347
121Agitation (HP:0000713)1.95592769
122Amblyopia (HP:0000646)1.95363562
123Neuronal loss in central nervous system (HP:0002529)1.94824113
124Confusion (HP:0001289)1.94199232
125Termporal pattern (HP:0011008)1.94135272
126Insidious onset (HP:0003587)1.94135272
127Hypsarrhythmia (HP:0002521)1.92898703
128Gout (HP:0001997)1.92263122
129Craniofacial dystonia (HP:0012179)1.91736342
130Wide cranial sutures (HP:0010537)1.91303627
131Postural tremor (HP:0002174)1.90693077
132Lower limb muscle weakness (HP:0007340)1.90578560
133Distal upper limb amyotrophy (HP:0007149)1.90174519
134Upper limb amyotrophy (HP:0009129)1.90174519
135Adrenal overactivity (HP:0002717)1.89653889
136Insomnia (HP:0100785)1.89526719
137Tetraplegia (HP:0002445)1.89066161
138Irregular epiphyses (HP:0010582)1.88982606
139Neurofibrillary tangles (HP:0002185)1.88898478
140Abnormality of renin-angiotensin system (HP:0000847)1.88860204
141Megalencephaly (HP:0001355)1.88620565
142Akinesia (HP:0002304)1.88523761
143Gait ataxia (HP:0002066)1.88292605
144Sparse lateral eyebrow (HP:0005338)1.87479544
145Papilledema (HP:0001085)1.87351356
146Abnormality of the dental root (HP:0006486)1.86299872
147Taurodontia (HP:0000679)1.86299872
148Abnormality of permanent molar morphology (HP:0011071)1.86299872
149Psychosis (HP:0000709)1.85068524
150Spinal canal stenosis (HP:0003416)1.84624145
151Constipation (HP:0002019)1.84425586
152Rapidly progressive (HP:0003678)1.83318052
153Progressive inability to walk (HP:0002505)1.82494913
154Hyperactive renin-angiotensin system (HP:0000841)1.81627871
155Hypophosphatemia (HP:0002148)1.80676009
156Hand muscle atrophy (HP:0009130)1.78643631
157Hypotension (HP:0002615)1.77982150
158Skin pits (HP:0100276)1.77599669
159Coarse facial features (HP:0000280)1.76215352
160Stridor (HP:0010307)1.72607333
161Mild short stature (HP:0003502)1.71413672
162Germ cell neoplasia (HP:0100728)1.70358208
163Cholecystitis (HP:0001082)1.70073729
164Abnormal gallbladder physiology (HP:0012438)1.70073729
165Atrioventricular block (HP:0001678)1.68956761
166Tracheal stenosis (HP:0002777)1.68265540
167Myopathic facies (HP:0002058)1.68040705
168Bradycardia (HP:0001662)1.66940147
169Abnormality of molar morphology (HP:0011070)1.65778064
170Abnormality of molar (HP:0011077)1.65778064
171Nephrolithiasis (HP:0000787)1.65482088
172Hypercalciuria (HP:0002150)1.65127531
173Proximal tubulopathy (HP:0000114)1.64402492
174Hyperaldosteronism (HP:0000859)1.62070061
175Centrally nucleated skeletal muscle fibers (HP:0003687)1.62065396
176Truncus arteriosus (HP:0001660)1.60852192
177Hypothermia (HP:0002045)1.60835770

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK34.29425434
2EPHA23.64864589
3MAP3K93.44768758
4EPHA43.27542009
5SMG12.84310486
6CAMKK22.63241888
7LMTK22.48424008
8CAMKK12.44388130
9EEF2K2.42819937
10MAP3K42.41971403
11MINK12.35116728
12DAPK22.29819037
13KSR22.28716100
14ERN12.22024962
15SIK12.21660648
16PAK62.19025620
17AKT31.99803124
18PRKD31.99489985
19ICK1.95264283
20PKN21.91602846
21MST1R1.84483896
22TESK11.81891569
23MARK11.79506239
24STK381.79226501
25NTRK11.76428426
26MAP2K71.75801838
27PDK21.75267097
28NTRK21.70065126
29RIPK41.68920000
30RIPK11.61669605
31MAP2K41.57897255
32WNK11.53175551
33CDK121.52327261
34PHKG11.47195528
35PHKG21.47195528
36CDK51.42596616
37PRPF4B1.36491778
38ARAF1.33700893
39MAP3K21.30335358
40WNK41.25809031
41KSR11.22468780
42MAP3K31.21662404
43UHMK11.20837387
44CAMK1G1.20661229
45OXSR11.19901762
46SGK4941.15842194
47SGK2231.15842194
48TAOK11.13708130
49MAP3K131.13603674
50CAMK11.13485614
51RPS6KA21.13407004
52PINK11.13273389
53DDR21.13244892
54TESK21.11245255
55CDK191.10415532
56PRKCH1.07537947
57PRKCG1.06790623
58DAPK11.06725207
59TNIK1.06368658
60GRK51.04368441
61MAP3K121.01642158
62PRKG21.01282995
63SIK21.00707506
64TYRO30.99102331
65STK110.97582851
66SGK30.94954427
67FES0.93432046
68PAK30.93180806
69SGK20.90510425
70CAMK2B0.90218816
71FGFR40.88632522
72CDC42BPA0.88409316
73CAMK2A0.88019286
74LATS20.87251751
75MAPK130.87011479
76PDPK10.84736114
77ERBB20.84538882
78MAPK120.84238354
79CAMK2D0.83973734
80MAP3K70.83210538
81PTK60.81892013
82PDK10.80680413
83MAPKAPK30.80180383
84RET0.78683815
85CAMK40.77653382
86MAP3K100.76318187
87DMPK0.76007409
88ALK0.75778426
89CAMK2G0.74245105
90MTOR0.73468343
91CDK150.73391162
92PNCK0.73069887
93MAP2K20.72526289
94CDK180.71833038
95STK390.71543337
96MAP3K10.71207245
97SGK10.70522584
98CAMK1D0.69448339
99NEK10.69206181
100SCYL20.68828535
101MARK20.67880401
102CDK140.67477858
103PRKD20.67260088
104PLK20.66987428
105PTK2B0.66633668
106MAP3K110.66256247
107MET0.63893977
108MAPK40.63784119
109TRIB30.63715552
110CDK11A0.62738744
111ACVR1B0.58031647
112RAF10.57912766
113EPHB10.57552822
114WNK30.54365232
115DYRK1A0.53221424
116AKT20.52198133
117RPS6KA30.51981090
118PTK20.51256007
119FER0.49035402
120NME10.48983697
121RPS6KL10.48680893
122RPS6KC10.48680893
123PRKCE0.48471208
124ILK0.48178726
125MAP2K10.47822135
126ROCK20.47503735
127DAPK30.47014948
128PRKCI0.46496987
129FYN0.45950732
130MAPK80.45711420
131DYRK1B0.45696729
132CSNK1A10.45512688
133MAPK100.44861628
134TNK20.44812288
135NEK60.43149909
136BMPR20.43007388
137PRKCZ0.42712224
138PDK30.42538757
139PDK40.42538757
140PAK40.41989865
141HIPK20.40955216
142MAP2K60.40895541
143PRKD10.40665522
144MUSK0.40653530
145PRKAA10.38095119
146MYLK0.37180153

Predicted pathways (KEGG)

RankGene SetZ-score
1Cyanoamino acid metabolism_Homo sapiens_hsa004604.20342458
2Nicotine addiction_Homo sapiens_hsa050333.18765118
3Synaptic vesicle cycle_Homo sapiens_hsa047212.95340939
4Circadian entrainment_Homo sapiens_hsa047132.54944483
5Long-term potentiation_Homo sapiens_hsa047202.47505218
6Olfactory transduction_Homo sapiens_hsa047402.45788668
7GABAergic synapse_Homo sapiens_hsa047272.44405004
8Glutamatergic synapse_Homo sapiens_hsa047242.42727379
9Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.38915344
10Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.38572180
11Morphine addiction_Homo sapiens_hsa050322.18739735
12Amphetamine addiction_Homo sapiens_hsa050312.15677908
13Salivary secretion_Homo sapiens_hsa049702.12958911
14Insulin secretion_Homo sapiens_hsa049112.04937215
15Vitamin digestion and absorption_Homo sapiens_hsa049772.04179917
16Fructose and mannose metabolism_Homo sapiens_hsa000512.03038276
17Renin-angiotensin system_Homo sapiens_hsa046142.00212721
18Gastric acid secretion_Homo sapiens_hsa049712.00097149
19Fat digestion and absorption_Homo sapiens_hsa049751.99795652
20Dopaminergic synapse_Homo sapiens_hsa047281.89442081
21Taste transduction_Homo sapiens_hsa047421.87706067
22Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.83747574
23Aldosterone synthesis and secretion_Homo sapiens_hsa049251.82795740
24Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.79079902
25Cholinergic synapse_Homo sapiens_hsa047251.77504623
26Arginine and proline metabolism_Homo sapiens_hsa003301.74029311
27Long-term depression_Homo sapiens_hsa047301.67564344
28Histidine metabolism_Homo sapiens_hsa003401.63175262
29Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.62130145
30Calcium signaling pathway_Homo sapiens_hsa040201.51819727
31Oxytocin signaling pathway_Homo sapiens_hsa049211.50282666
32Cardiac muscle contraction_Homo sapiens_hsa042601.49139630
33Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.48889040
34Cocaine addiction_Homo sapiens_hsa050301.48664411
35Type II diabetes mellitus_Homo sapiens_hsa049301.41367078
36Renin secretion_Homo sapiens_hsa049241.41008584
37Pancreatic secretion_Homo sapiens_hsa049721.40505642
38Phenylalanine metabolism_Homo sapiens_hsa003601.38863940
39GnRH signaling pathway_Homo sapiens_hsa049121.32551930
40Galactose metabolism_Homo sapiens_hsa000521.31863698
41Nitrogen metabolism_Homo sapiens_hsa009101.31519540
42Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.28660193
43Serotonergic synapse_Homo sapiens_hsa047261.28464386
44cAMP signaling pathway_Homo sapiens_hsa040241.26194311
45Gap junction_Homo sapiens_hsa045401.20063578
46Collecting duct acid secretion_Homo sapiens_hsa049661.18885293
47Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.13802455
48* Phosphatidylinositol signaling system_Homo sapiens_hsa040701.13622690
49Biosynthesis of amino acids_Homo sapiens_hsa012301.13105224
50Dilated cardiomyopathy_Homo sapiens_hsa054141.10109827
51Tyrosine metabolism_Homo sapiens_hsa003501.07442466
52Sulfur relay system_Homo sapiens_hsa041221.07238539
53cGMP-PKG signaling pathway_Homo sapiens_hsa040221.06731218
54Estrogen signaling pathway_Homo sapiens_hsa049151.05578662
55Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.03930782
56AMPK signaling pathway_Homo sapiens_hsa041520.96610634
57Thyroid hormone synthesis_Homo sapiens_hsa049180.95644685
58Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.93683323
59Vascular smooth muscle contraction_Homo sapiens_hsa042700.93507919
60Fatty acid biosynthesis_Homo sapiens_hsa000610.92469460
61Carbohydrate digestion and absorption_Homo sapiens_hsa049730.92386242
62Dorso-ventral axis formation_Homo sapiens_hsa043200.89305881
63Bile secretion_Homo sapiens_hsa049760.87867381
64Carbon metabolism_Homo sapiens_hsa012000.87425216
65Glioma_Homo sapiens_hsa052140.85967458
66Pentose phosphate pathway_Homo sapiens_hsa000300.85779814
67Thyroid cancer_Homo sapiens_hsa052160.83848381
68Phospholipase D signaling pathway_Homo sapiens_hsa040720.83556939
69PPAR signaling pathway_Homo sapiens_hsa033200.83073575
70Melanogenesis_Homo sapiens_hsa049160.81833812
71Starch and sucrose metabolism_Homo sapiens_hsa005000.81073818
72Vibrio cholerae infection_Homo sapiens_hsa051100.80355305
73Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.80237574
74ErbB signaling pathway_Homo sapiens_hsa040120.79795800
75Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.78985427
76Pentose and glucuronate interconversions_Homo sapiens_hsa000400.72632896
77Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.69663002
78Autoimmune thyroid disease_Homo sapiens_hsa053200.69569883
79Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.68955400
80Axon guidance_Homo sapiens_hsa043600.68891351
81Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.68750456
82Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.68200831
83Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.67194598
84Vitamin B6 metabolism_Homo sapiens_hsa007500.66555598
85Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.65795125
86Choline metabolism in cancer_Homo sapiens_hsa052310.65652316
87Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.64625058
88Fatty acid metabolism_Homo sapiens_hsa012120.63480518
89Glucagon signaling pathway_Homo sapiens_hsa049220.61870432
90Mineral absorption_Homo sapiens_hsa049780.61054385
912-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.60125985
92Pyruvate metabolism_Homo sapiens_hsa006200.59507920
93Circadian rhythm_Homo sapiens_hsa047100.57094952
94Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.56911683
95Thyroid hormone signaling pathway_Homo sapiens_hsa049190.55732555
96MAPK signaling pathway_Homo sapiens_hsa040100.55195154
97Alzheimers disease_Homo sapiens_hsa050100.54804711
98Oocyte meiosis_Homo sapiens_hsa041140.54490614
99VEGF signaling pathway_Homo sapiens_hsa043700.53780081
100* Inositol phosphate metabolism_Homo sapiens_hsa005620.52554605
101Neurotrophin signaling pathway_Homo sapiens_hsa047220.52431785
102Sphingolipid metabolism_Homo sapiens_hsa006000.52222080
103Fatty acid degradation_Homo sapiens_hsa000710.50755817
104Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.50376179
105Insulin resistance_Homo sapiens_hsa049310.50065286
106Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.49245490
107Butanoate metabolism_Homo sapiens_hsa006500.46797843
108Endocytosis_Homo sapiens_hsa041440.46151473
109Central carbon metabolism in cancer_Homo sapiens_hsa052300.45768989
110mTOR signaling pathway_Homo sapiens_hsa041500.45510485
111Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.44789202
112Longevity regulating pathway - mammal_Homo sapiens_hsa042110.44574893
113Rap1 signaling pathway_Homo sapiens_hsa040150.44532867
114Glycerolipid metabolism_Homo sapiens_hsa005610.44185102
115Insulin signaling pathway_Homo sapiens_hsa049100.42483700
116Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.41831607
117Notch signaling pathway_Homo sapiens_hsa043300.41425982
118Adipocytokine signaling pathway_Homo sapiens_hsa049200.41288806
119Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.40577118
120Sphingolipid signaling pathway_Homo sapiens_hsa040710.38264658
121Ras signaling pathway_Homo sapiens_hsa040140.37041200
122Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.36497054
123Glycerophospholipid metabolism_Homo sapiens_hsa005640.33585353
124Tight junction_Homo sapiens_hsa045300.33209297
125Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.30899470
126Phototransduction_Homo sapiens_hsa047440.30805733
127Arginine biosynthesis_Homo sapiens_hsa002200.30704743
128Lysine degradation_Homo sapiens_hsa003100.29435302
129Protein digestion and absorption_Homo sapiens_hsa049740.29033565
130Non-small cell lung cancer_Homo sapiens_hsa052230.28733605
131Oxidative phosphorylation_Homo sapiens_hsa001900.28578241
132Parkinsons disease_Homo sapiens_hsa050120.28255736
133Endometrial cancer_Homo sapiens_hsa052130.28159071
134Ovarian steroidogenesis_Homo sapiens_hsa049130.27048590

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