INPP5K

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein with 5-phosphatase activity toward polyphosphate inositol. The protein localizes to the cytosol in regions lacking actin stress fibers. It is thought that this protein may negatively regulate the actin cytoskeleton. Alternatively spliced transcript variants encoding different isoforms have been identified. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of gamma-delta T cell activation (GO:0046645)7.24912407
2antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.99029543
3antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.99029543
4antigen processing and presentation of endogenous antigen (GO:0019883)5.76116470
5regulation of gamma-delta T cell differentiation (GO:0045586)5.74936607
6regulation of gamma-delta T cell activation (GO:0046643)5.33069276
7positive regulation of B cell differentiation (GO:0045579)4.95133656
8antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.87985303
9negative regulation of erythrocyte differentiation (GO:0045647)4.34739475
10positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.29931883
11mast cell activation (GO:0045576)4.29066091
12regulation of B cell differentiation (GO:0045577)4.24474377
13antigen processing and presentation via MHC class Ib (GO:0002475)4.22313806
14regulation of B cell receptor signaling pathway (GO:0050855)4.20618616
15negative thymic T cell selection (GO:0045060)4.10354625
16leukocyte aggregation (GO:0070486)4.07643159
17negative T cell selection (GO:0043383)4.05898094
18positive thymic T cell selection (GO:0045059)4.00183873
19B cell receptor signaling pathway (GO:0050853)3.98770610
20endosome to melanosome transport (GO:0035646)3.85782246
21endosome to pigment granule transport (GO:0043485)3.85782246
22regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.75752094
23megakaryocyte development (GO:0035855)3.75053729
24response to interleukin-15 (GO:0070672)3.73260684
25definitive hemopoiesis (GO:0060216)3.71216061
26negative regulation of lymphocyte mediated immunity (GO:0002707)3.70122148
27tolerance induction (GO:0002507)3.68567354
28mast cell degranulation (GO:0043303)3.61426116
29mast cell activation involved in immune response (GO:0002279)3.61426116
30mature B cell differentiation involved in immune response (GO:0002313)3.60900662
31neutrophil activation (GO:0042119)3.59283785
32detection of other organism (GO:0098543)3.57213497
33cellular extravasation (GO:0045123)3.56891232
34T cell homeostasis (GO:0043029)3.54795314
35detection of bacterium (GO:0016045)3.54415146
36positive regulation of tolerance induction (GO:0002645)3.52088206
37myeloid dendritic cell activation (GO:0001773)3.44476725
38modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.41002754
39positive regulation by organism of defense response of other organism involved in symbiotic interact3.41002754
40modulation by symbiont of host immune response (GO:0052553)3.41002754
41positive regulation by symbiont of host defense response (GO:0052509)3.41002754
42modulation by symbiont of host defense response (GO:0052031)3.41002754
43modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.41002754
44positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)3.40759631
45positive regulation of natural killer cell mediated immunity (GO:0002717)3.40759631
46negative regulation of leukocyte mediated immunity (GO:0002704)3.39471287
47regulation of T cell mediated cytotoxicity (GO:0001914)3.39240967
48positive T cell selection (GO:0043368)3.38562347
49neutrophil activation involved in immune response (GO:0002283)3.38019193
50NIK/NF-kappaB signaling (GO:0038061)3.34799052
51positive regulation of granulocyte differentiation (GO:0030854)3.34646960
52positive regulation of T cell mediated cytotoxicity (GO:0001916)3.32062418
53granulocyte activation (GO:0036230)3.30374648
54regulation of natural killer cell mediated immunity (GO:0002715)3.28955709
55regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.28955709
56cellular response to interleukin-15 (GO:0071350)3.25901642
57negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)3.25646170
58mature B cell differentiation (GO:0002335)3.22860019
59myeloid cell activation involved in immune response (GO:0002275)3.21666756
60fibroblast migration (GO:0010761)3.21377258
61interferon-gamma production (GO:0032609)3.21093575
62Arp2/3 complex-mediated actin nucleation (GO:0034314)3.20962070
63platelet dense granule organization (GO:0060155)3.19671607
64negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.18310276
65regulation of mast cell degranulation (GO:0043304)3.16833146
66thymic T cell selection (GO:0045061)3.15772535
67cellular response to type I interferon (GO:0071357)3.14609706
68type I interferon signaling pathway (GO:0060337)3.14609706
69response to type I interferon (GO:0034340)3.14475017
70T cell migration (GO:0072678)3.13293142
71T cell selection (GO:0045058)3.12630617
72regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.12540300
73positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)3.10121749
74mucosal-associated lymphoid tissue development (GO:0048537)3.07217013
75Peyers patch development (GO:0048541)3.07217013
76response to protozoan (GO:0001562)3.06645427
77regulation of interleukin-12 biosynthetic process (GO:0045075)3.05889858
78response to muramyl dipeptide (GO:0032495)3.05858022
79germinal center formation (GO:0002467)3.05234607
80regulation of T cell tolerance induction (GO:0002664)3.04059186
81regulation of tolerance induction (GO:0002643)3.02867686
82leukocyte degranulation (GO:0043299)3.02576224
83regulation of interferon-beta biosynthetic process (GO:0045357)3.01602065
84macrophage activation involved in immune response (GO:0002281)3.00784471
85negative regulation of interleukin-12 production (GO:0032695)3.00167263
86L-fucose catabolic process (GO:0042355)2.99789152
87fucose catabolic process (GO:0019317)2.99789152
88L-fucose metabolic process (GO:0042354)2.99789152
89immunoglobulin mediated immune response (GO:0016064)2.99161038
90embryonic hemopoiesis (GO:0035162)2.97814687
91defense response to protozoan (GO:0042832)2.97708507
92lymphocyte homeostasis (GO:0002260)2.96824717
93positive regulation of natural killer cell differentiation (GO:0032825)2.94332017
94ribosomal small subunit assembly (GO:0000028)2.93545812
95regulation of regulatory T cell differentiation (GO:0045589)2.92443815
96antigen receptor-mediated signaling pathway (GO:0050851)2.91832133
97regulation of T cell receptor signaling pathway (GO:0050856)2.91508097
98negative regulation of T cell mediated immunity (GO:0002710)2.90699447
99leukocyte homeostasis (GO:0001776)2.89215872
100negative regulation of nitric oxide biosynthetic process (GO:0045019)2.88715853
101respiratory burst (GO:0045730)2.87241051
102positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.86813556
103positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)2.86233082
104regulation of erythrocyte differentiation (GO:0045646)2.84944034
105regulation of mast cell activation involved in immune response (GO:0033006)2.84344359
106negative regulation of glycoprotein biosynthetic process (GO:0010561)2.83711272
107negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.82451883
108negative regulation of T-helper cell differentiation (GO:0045623)2.82451883
109regulation of myeloid leukocyte mediated immunity (GO:0002886)2.82409651
110regulation of necroptotic process (GO:0060544)2.82345876
111cellular response to exogenous dsRNA (GO:0071360)2.81749117
112negative regulation of phagocytosis (GO:0050765)2.79652004
113negative regulation of interleukin-6 production (GO:0032715)2.79488187
114detection of external biotic stimulus (GO:0098581)2.78942857
115positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.77459036
116regulation of leukocyte degranulation (GO:0043300)2.76826400
117lymph node development (GO:0048535)2.76633090
118hepatocyte apoptotic process (GO:0097284)2.75985230
119negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)2.75572118
120interferon-gamma-mediated signaling pathway (GO:0060333)2.75210728
121regulation of alpha-beta T cell proliferation (GO:0046640)2.74491796
122myeloid dendritic cell differentiation (GO:0043011)2.73759912
123regulation of leukocyte mediated cytotoxicity (GO:0001910)2.73292887
124positive regulation of mast cell activation (GO:0033005)2.72318330
125positive regulation of leukocyte mediated cytotoxicity (GO:0001912)2.69969364
126angiogenesis involved in wound healing (GO:0060055)2.68739450
127fucosylation (GO:0036065)2.67911751
128regulation of platelet aggregation (GO:0090330)2.65665388
129regulation of defense response to virus by virus (GO:0050690)2.65188940
130leukocyte cell-cell adhesion (GO:0007159)2.64935538
131negative regulation of innate immune response (GO:0045824)2.64836028
132B cell mediated immunity (GO:0019724)2.62767558
133negative regulation of type 2 immune response (GO:0002829)2.62026298
134regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)2.61754055
135regulation of mast cell activation (GO:0033003)2.61283864
136negative regulation of cell killing (GO:0031342)2.61215377
137negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.61215377
138positive regulation of cell killing (GO:0031343)2.60053412
139dendritic cell chemotaxis (GO:0002407)2.59333087
140response to peptidoglycan (GO:0032494)2.58642019
141regulation of granulocyte differentiation (GO:0030852)2.58571521
142regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.57276101
143negative regulation of T cell receptor signaling pathway (GO:0050860)2.56137713
144actin nucleation (GO:0045010)2.56018663
145regulation of cell killing (GO:0031341)2.55739959
146regulation of T-helper 2 cell differentiation (GO:0045628)2.53719116
147positive regulation of macrophage differentiation (GO:0045651)2.50769469
148activated T cell proliferation (GO:0050798)2.49800101
149regulation of T cell mediated immunity (GO:0002709)2.48393245

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human5.01288822
2BP1_19119308_ChIP-ChIP_Hs578T_Human4.73093499
3FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.44745858
4STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.26681512
5MECOM_23826213_ChIP-Seq_KASUMI_Mouse4.07185275
6SCL_19346495_ChIP-Seq_HPC-7_Human4.04483649
7IRF8_22096565_ChIP-ChIP_GC-B_Mouse4.00747333
8IRF8_21731497_ChIP-ChIP_J774_Mouse3.53807236
9RUNX1_20887958_ChIP-Seq_HPC-7_Mouse3.47546582
10SPI1_22096565_ChIP-ChIP_GC-B_Mouse3.20692317
11RUNX_20019798_ChIP-Seq_JUKART_Human3.00872828
12IRF8_27001747_Chip-Seq_BMDM_Mouse2.73838064
13MYB_21317192_ChIP-Seq_ERMYB_Mouse2.70280540
14STAT4_19710469_ChIP-ChIP_TH1__Mouse2.58793290
15LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.58782730
16IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.58198791
17* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.55824026
18SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.47010026
19STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.46004642
20MYB_26560356_Chip-Seq_TH2_Human2.44447032
21NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.43919416
22FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.38620946
23VDR_21846776_ChIP-Seq_THP-1_Human2.38155803
24LMO2_20887958_ChIP-Seq_HPC-7_Mouse2.36364047
25MEIS1_20887958_ChIP-Seq_HPC-7_Mouse2.31643488
26GATA1_22025678_ChIP-Seq_K562_Human2.31229722
27MAF_26560356_Chip-Seq_TH1_Human2.30278758
28SPI1_23547873_ChIP-Seq_NB4_Human2.29218054
29MYC_22102868_ChIP-Seq_BL_Human2.25414336
30* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.20349457
31RUNX1_22412390_ChIP-Seq_EML_Mouse2.17608277
32MYB_26560356_Chip-Seq_TH1_Human2.08837033
33VDR_24763502_ChIP-Seq_THP-1_Human2.07819990
34E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.03090211
35UTX_26944678_Chip-Seq_JUKART_Human2.00765528
36LXR_22292898_ChIP-Seq_THP-1_Human1.94746068
37GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.94376028
38GATA3_27048872_Chip-Seq_THYMUS_Human1.88826139
39NOTCH1_21737748_ChIP-Seq_TLL_Human1.87974254
40EGR1_19374776_ChIP-ChIP_THP-1_Human1.86295176
41TCF7_22412390_ChIP-Seq_EML_Mouse1.85665976
42GATA1_19941827_ChIP-Seq_MEL_Mouse1.82972662
43GATA2_21666600_ChIP-Seq_HMVEC_Human1.79590774
44SPI1_23127762_ChIP-Seq_K562_Human1.79119448
45BRD4_27068464_Chip-Seq_AML-cells_Mouse1.71380800
46NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.66049905
47RARG_19884340_ChIP-ChIP_MEFs_Mouse1.64945807
48ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.64444415
49VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.59707013
50GATA1_22383799_ChIP-Seq_G1ME_Mouse1.53435049
51NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.52736087
52TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.51923474
53* GATA2_22383799_ChIP-Seq_G1ME_Mouse1.47823039
54TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.47505515
55* CTCF_27219007_Chip-Seq_ERYTHROID_Human1.47407712
56STAT6_21828071_ChIP-Seq_BEAS2B_Human1.45591594
57P68_20966046_ChIP-Seq_HELA_Human1.44682472
58ELF1_20517297_ChIP-Seq_JURKAT_Human1.43619433
59SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.33407860
60SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.31503447
61GATA1_19941826_ChIP-Seq_K562_Human1.31400051
62MAF_26560356_Chip-Seq_TH2_Human1.31252319
63SA1_27219007_Chip-Seq_ERYTHROID_Human1.30775720
64TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.29859775
65PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.29835823
66KDM2B_26808549_Chip-Seq_JURKAT_Human1.29203681
67TET1_21451524_ChIP-Seq_MESCs_Mouse1.28508479
68GATA3_26560356_Chip-Seq_TH2_Human1.28312631
69STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.26518556
70PU_27001747_Chip-Seq_BMDM_Mouse1.25656572
71PU.1_20513432_ChIP-Seq_Bcells_Mouse1.25407958
72Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.24749867
73ELF1_17652178_ChIP-ChIP_JURKAT_Human1.22091371
74CIITA_25753668_ChIP-Seq_RAJI_Human1.20899669
75PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.20425824
76STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.19334057
77* CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.17314324
78* CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.17026516
79RACK7_27058665_Chip-Seq_MCF-7_Human1.16927271
80GATA2_19941826_ChIP-Seq_K562_Human1.16797709
81KDM2B_26808549_Chip-Seq_SUP-B15_Human1.16499457
82NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.16052269
83RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.15581553
84KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.13570301
85GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.13525741
86ERG_20887958_ChIP-Seq_HPC-7_Mouse1.12130717
87* CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.11290864
88TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.10645027
89HOXB4_20404135_ChIP-ChIP_EML_Mouse1.09778450
90* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.09358082
91TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.07871922
92THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.07073658
93SPI1_20517297_ChIP-Seq_HL60_Human1.06467382
94SA1_27219007_Chip-Seq_Bcells_Human1.05832766
95SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.05399315
96SMC4_20622854_ChIP-Seq_HELA_Human1.05395815
97IKZF1_21737484_ChIP-ChIP_HCT116_Human1.04687828
98PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.03724802
99* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.03142609
100ELK3_25401928_ChIP-Seq_HUVEC_Human1.02966622
101SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.01978595
102KDM2B_26808549_Chip-Seq_DND41_Human1.01526826
103GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.01501404
104* CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.01145049
105PPARA_22158963_ChIP-Seq_LIVER_Mouse1.00835527
106* CTCF_21964334_ChIP-Seq_BJAB-B_Human1.00756319
107E2F1_20622854_ChIP-Seq_HELA_Human1.00409497
108SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.00331182
109PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.99670543
110* CTCF_26484167_Chip-Seq_Bcells_Mouse0.98916957
111* PHF8_20622854_ChIP-Seq_HELA_Human0.98821313
112DNAJC2_21179169_ChIP-ChIP_NT2_Human0.98762734
113CTCF_21964334_Chip-Seq_Bcells_Human0.98427970
114* BCL6_27268052_Chip-Seq_Bcells_Human0.96547092
115NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.92394041
116ETS1_22383799_ChIP-Seq_G1ME_Mouse0.92240285
117VDR_24787735_ChIP-Seq_THP-1_Human0.90681787
118TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.86854065
119GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.78528615
120P300_27268052_Chip-Seq_Bcells_Human0.76663309
121RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.76103962
122GATA1_19941827_ChIP-Seq_MEL86_Mouse0.75167048
123FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.73887482
124RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.73372755
125SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human0.72665809
126* BCOR_27268052_Chip-Seq_Bcells_Human0.72200440
127CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.71832413

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation3.94489489
2MP0005671_abnormal_response_to3.82962098
3MP0000685_abnormal_immune_system3.60231208
4MP0002396_abnormal_hematopoietic_system3.04755949
5MP0009785_altered_susceptibility_to2.85384957
6MP0003763_abnormal_thymus_physiology2.81281032
7MP0001800_abnormal_humoral_immune2.75738541
8MP0005000_abnormal_immune_tolerance2.65067527
9MP0005387_immune_system_phenotype2.61256003
10MP0001790_abnormal_immune_system2.61256003
11MP0002420_abnormal_adaptive_immunity2.56339170
12MP0003724_increased_susceptibility_to2.53679933
13MP0003436_decreased_susceptibility_to2.53664499
14MP0002452_abnormal_antigen_presenting2.53410723
15MP0001819_abnormal_immune_cell2.51889881
16MP0002148_abnormal_hypersensitivity_rea2.51108785
17MP0002723_abnormal_immune_serum2.50483825
18MP0005464_abnormal_platelet_physiology2.44609856
19MP0005025_abnormal_response_to2.41542090
20MP0002398_abnormal_bone_marrow2.38386833
21MP0003183_abnormal_peptide_metabolism2.36899988
22MP0002419_abnormal_innate_immunity2.36734999
23MP0000465_gastrointestinal_hemorrhage2.29151237
24MP0002166_altered_tumor_susceptibility2.19017546
25MP0000716_abnormal_immune_system2.14446033
26MP0004808_abnormal_hematopoietic_stem2.11817117
27MP0005075_abnormal_melanosome_morpholog2.00045600
28MP0002405_respiratory_system_inflammati1.96762630
29MP0000689_abnormal_spleen_morphology1.90945368
30MP0002722_abnormal_immune_system1.88854071
31MP0005174_abnormal_tail_pigmentation1.86773745
32MP0010155_abnormal_intestine_physiology1.85229073
33MP0001873_stomach_inflammation1.83642962
34MP0002429_abnormal_blood_cell1.80991415
35MP0004510_myositis1.80980067
36MP0004947_skin_inflammation1.77186944
37MP0001545_abnormal_hematopoietic_system1.75907471
38MP0005397_hematopoietic_system_phenotyp1.75907471
39MP0004147_increased_porphyrin_level1.75540989
40MP0009333_abnormal_splenocyte_physiolog1.75046587
41MP0006082_CNS_inflammation1.72763179
42* MP0004130_abnormal_muscle_cell1.68475427
43MP0009278_abnormal_bone_marrow1.68285021
44MP0001845_abnormal_inflammatory_respons1.67146310
45MP0003866_abnormal_defecation1.62299783
46MP0009840_abnormal_foam_cell1.61155091
47MP0002006_tumorigenesis1.57930470
48MP0000703_abnormal_thymus_morphology1.49957767
49MP0001853_heart_inflammation1.46844279
50MP0005670_abnormal_white_adipose1.46543181
51MP0004381_abnormal_hair_follicle1.44981383
52MP0005451_abnormal_body_composition1.44176033
53MP0002933_joint_inflammation1.41994913
54MP0005410_abnormal_fertilization1.37803217
55MP0003300_gastrointestinal_ulcer1.30305760
56MP0003656_abnormal_erythrocyte_physiolo1.27949086
57MP0001984_abnormal_olfaction1.27757939
58MP0001533_abnormal_skeleton_physiology1.27564738
59MP0008469_abnormal_protein_level1.23929989
60MP0009764_decreased_sensitivity_to1.22214380
61MP0000343_altered_response_to1.17413983
62MP0005310_abnormal_salivary_gland1.16546013
63MP0005666_abnormal_adipose_tissue1.16234825
64MP0002132_abnormal_respiratory_system1.12742465
65MP0003303_peritoneal_inflammation1.09175739
66MP0002009_preneoplasia1.08923272
67MP0003191_abnormal_cellular_cholesterol1.07372851
68MP0005058_abnormal_lysosome_morphology1.05549948
69MP0002877_abnormal_melanocyte_morpholog1.04119646
70MP0003172_abnormal_lysosome_physiology1.01241909
71MP0005390_skeleton_phenotype1.00617898
72MP0002095_abnormal_skin_pigmentation1.00265518
73MP0001879_abnormal_lymphatic_vessel0.98578358
74MP0008004_abnormal_stomach_pH0.96194790
75MP0000490_abnormal_crypts_of0.95602008
76MP0003943_abnormal_hepatobiliary_system0.90479783
77MP0000015_abnormal_ear_pigmentation0.89513970
78MP0001851_eye_inflammation0.88488572
79MP0002971_abnormal_brown_adipose0.87747159
80MP0005083_abnormal_biliary_tract0.86612230
81MP0002332_abnormal_exercise_endurance0.85850355
82MP0001986_abnormal_taste_sensitivity0.85771071
83MP0004883_abnormal_blood_vessel0.84303766
84MP0005535_abnormal_body_temperature0.83752193
85MP0002277_abnormal_respiratory_mucosa0.82350921
86MP0005375_adipose_tissue_phenotype0.82090059
87MP0008874_decreased_physiological_sensi0.81998449
88MP0003690_abnormal_glial_cell0.81937547
89MP0004185_abnormal_adipocyte_glucose0.81770522
90MP0000604_amyloidosis0.81297954
91MP0005164_abnormal_response_to0.79949909
92MP0009115_abnormal_fat_cell0.75687154
93MP0003279_aneurysm0.75381516
94MP0008260_abnormal_autophagy0.73804616
95MP0001958_emphysema0.72003512
96MP0003448_altered_tumor_morphology0.70996441
97MP0003828_pulmonary_edema0.69370869
98MP0003075_altered_response_to0.68827403
99MP0000750_abnormal_muscle_regeneration0.66369926
100MP0000249_abnormal_blood_vessel0.66021453
101MP0003329_amyloid_beta_deposits0.65536590
102MP0009763_increased_sensitivity_to0.65449706
103MP0005334_abnormal_fat_pad0.65108583
104MP0009765_abnormal_xenobiotic_induced0.63552096
105MP0002019_abnormal_tumor_incidence0.62753712
106MP0004264_abnormal_extraembryonic_tissu0.61629079
107MP0002909_abnormal_adrenal_gland0.61273228
108MP0003795_abnormal_bone_structure0.60273292
109MP0002998_abnormal_bone_remodeling0.59900721
110MP0005167_abnormal_blood-brain_barrier0.58736647
111MP0002136_abnormal_kidney_physiology0.58146847
112MP0003011_delayed_dark_adaptation0.58064118
113MP0003091_abnormal_cell_migration0.57851706
114MP0005584_abnormal_enzyme/coenzyme_acti0.57380092
115MP0000858_altered_metastatic_potential0.56968062
116MP0001765_abnormal_ion_homeostasis0.56179247
117MP0002254_reproductive_system_inflammat0.56130481
118MP0005166_decreased_susceptibility_to0.55924150
119MP0010368_abnormal_lymphatic_system0.55657347
120MP0005409_darkened_coat_color0.55652576
121MP0001663_abnormal_digestive_system0.54779698
122MP0003638_abnormal_response/metabolism_0.53618237
123MP0000371_diluted_coat_color0.53026962
124MP0004484_altered_response_of0.52151396
125MP0001191_abnormal_skin_condition0.51694705
126MP0000920_abnormal_myelination0.49369375
127MP0004036_abnormal_muscle_relaxation0.49259787

Predicted human phenotypes

RankGene SetZ-score
1Agammaglobulinemia (HP:0004432)5.12742706
2Recurrent bronchitis (HP:0002837)5.07658436
3Chronic otitis media (HP:0000389)4.69222771
4Abnormality of the nasal mucosa (HP:0000433)4.17812904
5Myositis (HP:0100614)4.12371977
6Petechiae (HP:0000967)4.10251205
7Elevated erythrocyte sedimentation rate (HP:0003565)4.09116655
8Panhypogammaglobulinemia (HP:0003139)4.06616148
9IgM deficiency (HP:0002850)4.06529331
10Recurrent abscess formation (HP:0002722)4.02826106
11Nasal polyposis (HP:0100582)3.96620781
12Abnormal delayed hypersensitivity skin test (HP:0002963)3.96356895
13Chronic mucocutaneous candidiasis (HP:0002728)3.91224897
14Recurrent cutaneous fungal infections (HP:0011370)3.91224897
15Interstitial pulmonary disease (HP:0006530)3.85028105
16Recurrent fungal infections (HP:0002841)3.80937100
17Colitis (HP:0002583)3.80334586
18Bronchitis (HP:0012387)3.65742613
19Inflammation of the large intestine (HP:0002037)3.62753039
20Chronic sinusitis (HP:0011109)3.59096748
21Gastrointestinal infarctions (HP:0005244)3.47403550
22Gastrointestinal inflammation (HP:0004386)3.46255339
23Thrombocytosis (HP:0001894)3.37990624
24Recurrent viral infections (HP:0004429)3.37736068
25Meningitis (HP:0001287)3.35591710
26Recurrent bacterial skin infections (HP:0005406)3.34445155
27Prolonged bleeding time (HP:0003010)3.25467597
28Increased IgE level (HP:0003212)3.23145183
29Recurrent skin infections (HP:0001581)3.19669346
30Gastrointestinal stroma tumor (HP:0100723)3.16468459
31Eczematoid dermatitis (HP:0000976)3.16249497
32Thyroiditis (HP:0100646)3.14119436
33Retrobulbar optic neuritis (HP:0100654)3.08780283
34Optic neuritis (HP:0100653)3.08780283
35Cellulitis (HP:0100658)3.06353187
36Orchitis (HP:0100796)3.05131025
37Recurrent sinusitis (HP:0011108)3.03091302
38Abnormality of T cell number (HP:0011839)2.94382408
39Abnormality of T cells (HP:0002843)2.86991614
40Epistaxis (HP:0000421)2.86032855
41Spontaneous hematomas (HP:0007420)2.85868198
42T lymphocytopenia (HP:0005403)2.84985886
43Hypoplasia of the thymus (HP:0000778)2.81262729
44Increased IgM level (HP:0003496)2.80646560
45Chest pain (HP:0100749)2.78922311
46Abnormality of T cell physiology (HP:0011840)2.78366097
47Recurrent gram-negative bacterial infections (HP:0005420)2.78255657
48Vasculitis (HP:0002633)2.77824318
49Abnormality of macrophages (HP:0004311)2.77037085
50Gingival bleeding (HP:0000225)2.72189807
51Stomatitis (HP:0010280)2.71641375
52Chronic diarrhea (HP:0002028)2.69927512
53IgG deficiency (HP:0004315)2.67225717
54Lymphopenia (HP:0001888)2.64980242
55Autoimmune thrombocytopenia (HP:0001973)2.58762481
56Loss of speech (HP:0002371)2.55235396
57Urticaria (HP:0001025)2.54451367
58Abnormality of cells of the lymphoid lineage (HP:0012140)2.54438690
59Abnormality of eosinophils (HP:0001879)2.53863210
60Dysostosis multiplex (HP:0000943)2.51382934
61Leukocytosis (HP:0001974)2.49054681
62Hypertriglyceridemia (HP:0002155)2.47478197
63Hemoptysis (HP:0002105)2.44753279
64Severe combined immunodeficiency (HP:0004430)2.42423385
65Hematochezia (HP:0002573)2.41455533
66Bronchiectasis (HP:0002110)2.37001250
67Vacuolated lymphocytes (HP:0001922)2.36901676
68Episodic fever (HP:0001954)2.36317482
69Gingivitis (HP:0000230)2.35704911
70Hypochromic microcytic anemia (HP:0004840)2.34859381
71Increased serum ferritin (HP:0003281)2.34688048
72Growth hormone excess (HP:0000845)2.32782261
73Encephalitis (HP:0002383)2.32448248
74Amyloidosis (HP:0011034)2.30458320
75Hypochromic anemia (HP:0001931)2.30184811
76Microcytic anemia (HP:0001935)2.28411967
77Constricted visual fields (HP:0001133)2.27276763
78Mediastinal lymphadenopathy (HP:0100721)2.27269465
79Hyperlipoproteinemia (HP:0010980)2.26757513
80Purpura (HP:0000979)2.25688246
81Abnormality of glycolipid metabolism (HP:0010969)2.23289542
82Abnormality of liposaccharide metabolism (HP:0010968)2.23289542
83Abnormality of glycosphingolipid metabolism (HP:0004343)2.23289542
84Recurrent otitis media (HP:0000403)2.21673185
85Hemorrhage of the eye (HP:0011885)2.19172928
86Osteomyelitis (HP:0002754)2.18658429
87Granulocytopenia (HP:0001913)2.18227685
88Hepatosplenomegaly (HP:0001433)2.17690967
89Slow saccadic eye movements (HP:0000514)2.17006315
90Aplastic anemia (HP:0001915)2.16310163
91Anorexia (HP:0002039)2.15737472
92Impaired platelet aggregation (HP:0003540)2.13534981
93Abnormal platelet function (HP:0011869)2.13534981
94Abnormality of B cell number (HP:0010975)2.12761390
95B lymphocytopenia (HP:0010976)2.12761390
96Abnormality of iron homeostasis (HP:0011031)2.11418342
97Abnormal platelet volume (HP:0011876)2.11133346
98Pulmonary infiltrates (HP:0002113)2.10381234
99Increased cerebral lipofuscin (HP:0011813)2.09950438
100Papilloma (HP:0012740)2.09566454
101Verrucae (HP:0200043)2.09566454
102Increased neuronal autofluorescent lipopigment (HP:0002074)2.09550541
103Asymmetric septal hypertrophy (HP:0001670)2.09099942
104Keratoconjunctivitis sicca (HP:0001097)2.08321811
105Combined immunodeficiency (HP:0005387)2.07113534
106Lymphoma (HP:0002665)2.06974593
107Sepsis (HP:0100806)2.06249383
108Arterial thrombosis (HP:0004420)2.05413085
109Vertebral compression fractures (HP:0002953)2.04990345
110Eosinophilia (HP:0001880)2.03613637
111Joint swelling (HP:0001386)2.01807918
112Pustule (HP:0200039)2.01028339
113Keratoconjunctivitis (HP:0001096)1.99240954
114Glomerulopathy (HP:0100820)1.98865336
115Rhinitis (HP:0012384)1.96245279
116Erythema (HP:0010783)1.95883213
117Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.95651683
118Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.95192136
119Emphysema (HP:0002097)1.94923576
120Obstructive lung disease (HP:0006536)1.93456023
121Chronic obstructive pulmonary disease (HP:0006510)1.93456023
122Easy fatigability (HP:0003388)1.93016699
123Hypoproteinemia (HP:0003075)1.92109656
124Acne (HP:0001061)1.91097089
125Amaurosis fugax (HP:0100576)1.90464365
126Vertigo (HP:0002321)1.90032367
127Hypergammaglobulinemia (HP:0010702)1.89103350
128Restrictive lung disease (HP:0002091)1.88645722
129IgA deficiency (HP:0002720)1.87648031
130Acute hepatic failure (HP:0006554)1.87617094
131Nonprogressive disorder (HP:0003680)1.86900453
132Pulmonary embolism (HP:0002204)1.86663855
133Abnormality of the heme biosynthetic pathway (HP:0010472)1.85874506
134Dynein arm defect of respiratory motile cilia (HP:0012255)1.85743470
135Absent/shortened dynein arms (HP:0200106)1.85743470
136Neutropenia (HP:0001875)1.83872040
137Hypothermia (HP:0002045)1.82951274
138Segmental peripheral demyelination/remyelination (HP:0003481)1.81996753
139Abnormality of glycosaminoglycan metabolism (HP:0004371)1.79245735
140Abnormality of mucopolysaccharide metabolism (HP:0011020)1.79245735
141Abnormality of polysaccharide metabolism (HP:0011012)1.79245735
142Difficulty running (HP:0009046)1.78817395
143Keratitis (HP:0000491)1.75394195

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K13.90285215
2KIT3.25192094
3TESK23.15350054
4MAP2K33.07851594
5MAP3K132.68700558
6TXK2.66880973
7ZAP702.64139477
8TGFBR22.35751097
9TYK22.33093372
10SYK2.26508142
11BTK2.25992703
12MAP3K112.12178402
13TEC2.07544231
14MAP3K142.06961203
15IKBKE2.04780742
16TBK11.97573433
17CSF1R1.97061920
18JAK31.94594502
19TIE11.89879049
20TESK11.87782297
21STK101.81443679
22TAOK11.75835688
23EEF2K1.70387395
24KDR1.70130968
25BLK1.62652505
26IKBKB1.61179416
27SIK31.60409223
28TGFBR11.58329011
29CDK191.56885280
30RIPK41.56497348
31STK161.56125113
32ITK1.55548279
33MAP3K121.49277886
34MAP3K71.45313645
35FLT31.42353092
36MATK1.41232911
37IRAK41.40840402
38LRRK21.36531582
39TAOK21.35534009
40PIM21.34843210
41FES1.32283931
42LCK1.28908817
43MAP3K61.28901790
44HCK1.23625944
45MAP2K61.23327499
46TNK21.19806804
47PRKD21.18178901
48TNIK1.18029517
49SIK11.16648000
50MARK31.12564899
51JAK11.11309293
52CCNB11.08897269
53MAP2K21.08716473
54ERN11.08688764
55MAPKAPK51.08030701
56ADRBK21.04766248
57IRAK31.03818199
58PDK31.02945196
59PDK41.02945196
60CAMKK10.99933882
61PDK20.99842224
62PIM10.92603033
63MAP3K10.91285582
64LYN0.90657336
65NLK0.89368186
66CLK10.87861952
67GRK60.87819394
68RAF10.84718841
69STK240.83222717
70PDK10.82596913
71MAPK70.79116742
72TAOK30.77754344
73SIK20.76851517
74PIK3CG0.76696748
75TRPM70.74562332
76MYLK0.72476851
77ARAF0.71806710
78MAPKAPK30.70961255
79CAMKK20.70815731
80MARK20.70785490
81CHUK0.69473805
82DYRK1B0.68651400
83RPS6KB20.66506548
84CAMK10.66214590
85PTK60.65300568
86EPHB10.64932036
87STK380.64476696
88MAPK40.64199896
89SMG10.63893934
90RIPK10.63868905
91MAP3K30.63394008
92FGR0.63305504
93MAPK120.62976385
94JAK20.60439265
95EPHA30.59708002
96BMX0.59454399
97KSR20.58645453
98GRK50.57920934
99CSK0.57310382
100RPS6KC10.54043321
101RPS6KL10.54043321
102PRKCQ0.52689152
103RPS6KA20.51430160
104DAPK20.51350943
105PRKD10.50784169
106TTN0.50653931
107NEK90.49284057
108RPS6KA60.47952039
109IRAK10.44377539
110RPS6KA40.43986747
111MST40.43731437
112PTK2B0.42402960
113CDC42BPA0.42294031
114MAP3K50.41753858
115FGFR40.40693430
116LIMK10.38235887
117GRK70.37762977
118BCKDK0.36515033
119FGFR30.35783264
120PDPK10.35235847
121HIPK20.35067428
122PRKAA20.34720166
123MAPK110.33980554
124PRPF4B0.32967119
125BMPR1B0.32460317
126MUSK0.31054851
127RET0.29468196
128GRK10.29188639
129DAPK10.29085364
130FYN0.28770577
131TRIB30.28263616
132PRKCD0.28075794
133MAPKAPK20.26169276
134ILK0.25652988
135MAPK30.22341383

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053404.22078807
2B cell receptor signaling pathway_Homo sapiens_hsa046622.83094144
3Leishmaniasis_Homo sapiens_hsa051402.51195737
4Hematopoietic cell lineage_Homo sapiens_hsa046402.39623122
5Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.37956740
6Osteoclast differentiation_Homo sapiens_hsa043802.23426517
7Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.19295268
8NF-kappa B signaling pathway_Homo sapiens_hsa040642.05362051
9Measles_Homo sapiens_hsa051621.97475914
10Autoimmune thyroid disease_Homo sapiens_hsa053201.96184215
11Other glycan degradation_Homo sapiens_hsa005111.96074062
12T cell receptor signaling pathway_Homo sapiens_hsa046601.92159101
13Olfactory transduction_Homo sapiens_hsa047401.85112507
14Shigellosis_Homo sapiens_hsa051311.80672995
15Staphylococcus aureus infection_Homo sapiens_hsa051501.79401306
16NOD-like receptor signaling pathway_Homo sapiens_hsa046211.72778438
17Intestinal immune network for IgA production_Homo sapiens_hsa046721.72616953
18Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.72347559
19Platelet activation_Homo sapiens_hsa046111.71889666
20Antigen processing and presentation_Homo sapiens_hsa046121.71083506
21SNARE interactions in vesicular transport_Homo sapiens_hsa041301.70604000
22RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.68389706
23Jak-STAT signaling pathway_Homo sapiens_hsa046301.64971615
24Toll-like receptor signaling pathway_Homo sapiens_hsa046201.63741742
25Acute myeloid leukemia_Homo sapiens_hsa052211.62318928
26Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.55200649
27Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.50391885
28Chemokine signaling pathway_Homo sapiens_hsa040621.45932495
29Toxoplasmosis_Homo sapiens_hsa051451.43097225
30Caffeine metabolism_Homo sapiens_hsa002321.38392606
31Salmonella infection_Homo sapiens_hsa051321.34085303
32Influenza A_Homo sapiens_hsa051641.28564923
33Tuberculosis_Homo sapiens_hsa051521.25943853
34Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.25618969
35Pertussis_Homo sapiens_hsa051331.25509691
36Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.25429627
37Herpes simplex infection_Homo sapiens_hsa051681.24723288
38Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.20058987
39Leukocyte transendothelial migration_Homo sapiens_hsa046701.16389909
40Legionellosis_Homo sapiens_hsa051341.15741998
41Type I diabetes mellitus_Homo sapiens_hsa049401.14946749
42TNF signaling pathway_Homo sapiens_hsa046681.12150503
43Rheumatoid arthritis_Homo sapiens_hsa053231.10989874
44Hepatitis B_Homo sapiens_hsa051611.10539846
45Malaria_Homo sapiens_hsa051441.10422232
46Allograft rejection_Homo sapiens_hsa053301.09254139
47Neurotrophin signaling pathway_Homo sapiens_hsa047221.08393295
48Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.07438569
49Apoptosis_Homo sapiens_hsa042101.06973630
50Graft-versus-host disease_Homo sapiens_hsa053321.02916949
51Chronic myeloid leukemia_Homo sapiens_hsa052200.93992774
52VEGF signaling pathway_Homo sapiens_hsa043700.93146503
53Lysosome_Homo sapiens_hsa041420.92508030
54Transcriptional misregulation in cancer_Homo sapiens_hsa052020.92209556
55AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.85726914
56Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.81425435
57Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.80240026
58Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.79787645
59Prolactin signaling pathway_Homo sapiens_hsa049170.79400930
60Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.75975270
61Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.75006462
62Sulfur relay system_Homo sapiens_hsa041220.74557715
63Pancreatic cancer_Homo sapiens_hsa052120.71791186
64Hepatitis C_Homo sapiens_hsa051600.71237144
65Adipocytokine signaling pathway_Homo sapiens_hsa049200.68338743
66Glycerophospholipid metabolism_Homo sapiens_hsa005640.67392345
67* Phosphatidylinositol signaling system_Homo sapiens_hsa040700.64683305
68Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.61559190
69Epstein-Barr virus infection_Homo sapiens_hsa051690.61025921
70HTLV-I infection_Homo sapiens_hsa051660.60565347
71Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.59416056
72FoxO signaling pathway_Homo sapiens_hsa040680.59244409
73Endocytosis_Homo sapiens_hsa041440.58383226
74Carbohydrate digestion and absorption_Homo sapiens_hsa049730.58207891
75Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.57981272
76Asthma_Homo sapiens_hsa053100.55787628
77mTOR signaling pathway_Homo sapiens_hsa041500.55613596
78Colorectal cancer_Homo sapiens_hsa052100.55537963
79Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.55135303
80Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.54866572
81Sphingolipid signaling pathway_Homo sapiens_hsa040710.53328557
82Non-small cell lung cancer_Homo sapiens_hsa052230.52481377
83Longevity regulating pathway - mammal_Homo sapiens_hsa042110.52251315
84Endometrial cancer_Homo sapiens_hsa052130.52134276
85GnRH signaling pathway_Homo sapiens_hsa049120.51370594
86Glycerolipid metabolism_Homo sapiens_hsa005610.50323151
87Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.49753027
88Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.48495979
89Viral myocarditis_Homo sapiens_hsa054160.47915190
90PPAR signaling pathway_Homo sapiens_hsa033200.47567244
91ABC transporters_Homo sapiens_hsa020100.47415574
92Renal cell carcinoma_Homo sapiens_hsa052110.47087362
93N-Glycan biosynthesis_Homo sapiens_hsa005100.47024069
94Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.46781745
95* Insulin signaling pathway_Homo sapiens_hsa049100.45572269
96Glycosaminoglycan degradation_Homo sapiens_hsa005310.45056030
97Phagosome_Homo sapiens_hsa041450.43693266
98African trypanosomiasis_Homo sapiens_hsa051430.43650747
99Fructose and mannose metabolism_Homo sapiens_hsa000510.42922648
100MAPK signaling pathway_Homo sapiens_hsa040100.42572114
101Notch signaling pathway_Homo sapiens_hsa043300.41412663
102Sphingolipid metabolism_Homo sapiens_hsa006000.39341619
103Regulation of autophagy_Homo sapiens_hsa041400.39331540
104Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.36775685
105Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.36544128
106AMPK signaling pathway_Homo sapiens_hsa041520.36387202
107HIF-1 signaling pathway_Homo sapiens_hsa040660.36130218
108cAMP signaling pathway_Homo sapiens_hsa040240.36051958
109Viral carcinogenesis_Homo sapiens_hsa052030.35910047
110Choline metabolism in cancer_Homo sapiens_hsa052310.35640669
111Vascular smooth muscle contraction_Homo sapiens_hsa042700.35325406
112Insulin resistance_Homo sapiens_hsa049310.35232733
113Phospholipase D signaling pathway_Homo sapiens_hsa040720.32580228
114* Inositol phosphate metabolism_Homo sapiens_hsa005620.31161845
115Phototransduction_Homo sapiens_hsa047440.30649944
116Collecting duct acid secretion_Homo sapiens_hsa049660.30056045
117Renin secretion_Homo sapiens_hsa049240.29820835
118Pentose phosphate pathway_Homo sapiens_hsa000300.29414919
119Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.28351709
120Small cell lung cancer_Homo sapiens_hsa052220.27388603

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