INPPL1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is an SH2-containing 5'-inositol phosphatase that is involved in the regulation of insulin function. The encoded protein also plays a role in the regulation of epidermal growth factor receptor turnover and actin remodelling. Additionally, this gene supports metastatic growth in breast cancer and is a valuable biomarker for breast cancer. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1plasma membrane repair (GO:0001778)5.64098418
2sarcomere organization (GO:0045214)5.11996505
3cardiac myofibril assembly (GO:0055003)4.78554150
4negative regulation of potassium ion transmembrane transporter activity (GO:1901017)4.59496337
5actin-myosin filament sliding (GO:0033275)4.47980188
6muscle filament sliding (GO:0030049)4.47980188
7negative regulation of erythrocyte differentiation (GO:0045647)4.26204748
8myofibril assembly (GO:0030239)4.22012952
9mannose metabolic process (GO:0006013)4.16438566
10negative regulation of potassium ion transmembrane transport (GO:1901380)4.11990449
11Golgi transport vesicle coating (GO:0048200)4.07491180
12COPI coating of Golgi vesicle (GO:0048205)4.07491180
13actin-mediated cell contraction (GO:0070252)3.80580098
14regulation of skeletal muscle contraction (GO:0014819)3.74941761
15actomyosin structure organization (GO:0031032)3.72341052
16negative regulation of cell size (GO:0045792)3.67286410
17carnitine shuttle (GO:0006853)3.55550149
18planar cell polarity pathway involved in neural tube closure (GO:0090179)3.52352935
19regulation of p38MAPK cascade (GO:1900744)3.47831437
20apoptotic cell clearance (GO:0043277)3.46906966
21epithelial cell-cell adhesion (GO:0090136)3.38978603
22cardiac muscle cell development (GO:0055013)3.37992325
23actin filament-based movement (GO:0030048)3.36747183
24positive regulation of p38MAPK cascade (GO:1900745)3.32814538
25bundle of His cell to Purkinje myocyte communication (GO:0086069)3.28188997
26fatty acid transmembrane transport (GO:1902001)3.27107606
27cardiac cell development (GO:0055006)3.24371939
28regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.21330997
29embryonic process involved in female pregnancy (GO:0060136)3.17612605
30positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr3.15615660
31basement membrane organization (GO:0071711)3.13885901
32regulation of early endosome to late endosome transport (GO:2000641)3.13243896
33low-density lipoprotein particle clearance (GO:0034383)3.11317644
34cell-substrate junction assembly (GO:0007044)3.11064831
35activation of Rac GTPase activity (GO:0032863)3.10965126
36positive regulation of myotube differentiation (GO:0010831)3.08785589
37regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.07984980
38regulation of fatty acid beta-oxidation (GO:0031998)3.07951767
39retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.07748327
40positive regulation of blood vessel endothelial cell migration (GO:0043536)3.06981871
41cardiac muscle contraction (GO:0060048)3.06370387
42protein retention in ER lumen (GO:0006621)3.04881650
43regulation of histone H3-K27 methylation (GO:0061085)3.04616385
44positive regulation of fatty acid beta-oxidation (GO:0032000)3.04575261
45adherens junction assembly (GO:0034333)3.03782158
46regulation of glucose import in response to insulin stimulus (GO:2001273)3.03590457
47regulation of hippo signaling (GO:0035330)3.02666276
48vascular endothelial growth factor signaling pathway (GO:0038084)3.01002472
49apoptotic process involved in morphogenesis (GO:0060561)3.00640665
50striated muscle atrophy (GO:0014891)3.00320619
51protein localization to endosome (GO:0036010)2.99409501
52maternal placenta development (GO:0001893)2.99167249
53regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.99160601
54cell adhesion mediated by integrin (GO:0033627)2.98274752
55positive regulation of histone deacetylation (GO:0031065)2.97942844
56positive regulation of Cdc42 GTPase activity (GO:0043089)2.97288905
57response to laminar fluid shear stress (GO:0034616)2.97266048
58barbed-end actin filament capping (GO:0051016)2.96540633
59heart trabecula formation (GO:0060347)2.95163581
60maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.94757750
61regulation of fatty acid oxidation (GO:0046320)2.93469944
62pinocytosis (GO:0006907)2.90785482
63paraxial mesoderm development (GO:0048339)2.90106687
64hippo signaling (GO:0035329)2.89756979
65positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.89505567
66positive regulation of receptor recycling (GO:0001921)2.88787851
67tricarboxylic acid cycle (GO:0006099)2.87760144
68endothelial cell chemotaxis (GO:0035767)2.86600872
69regulation of tight junction assembly (GO:2000810)2.82472853
70regulation of sequestering of triglyceride (GO:0010889)2.82345473
71positive regulation of SMAD protein import into nucleus (GO:0060391)2.81967485
72regulation of cardioblast differentiation (GO:0051890)2.80814781
73focal adhesion assembly (GO:0048041)2.79691664
74cell-substrate adherens junction assembly (GO:0007045)2.79691664
75endodermal cell differentiation (GO:0035987)2.79549358
76cytoskeletal anchoring at plasma membrane (GO:0007016)2.79097580
77insulin-like growth factor receptor signaling pathway (GO:0048009)2.76417681
78regulation of SMAD protein import into nucleus (GO:0060390)2.76395675
79negative regulation of heart growth (GO:0061117)2.76164949
80negative regulation of cardiac muscle tissue growth (GO:0055022)2.76164949
81polarized epithelial cell differentiation (GO:0030859)2.76072951
82atrioventricular valve morphogenesis (GO:0003181)2.76016199
83negative regulation of fatty acid transport (GO:2000192)2.75955964
84positive regulation of glycogen biosynthetic process (GO:0045725)2.75923697
85creatine metabolic process (GO:0006600)2.75078405
86positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.73390515
87regulation of extracellular matrix disassembly (GO:0010715)2.73017495
88ventricular cardiac muscle cell action potential (GO:0086005)2.72700841
89cell migration involved in sprouting angiogenesis (GO:0002042)2.72189934
904-hydroxyproline metabolic process (GO:0019471)2.70986842
91striated muscle contraction (GO:0006941)2.68927136
92endocardial cushion development (GO:0003197)2.66561047
93lysine catabolic process (GO:0006554)2.66415996
94lysine metabolic process (GO:0006553)2.66415996
95protein heterotrimerization (GO:0070208)2.65672971
96coronary vasculature morphogenesis (GO:0060977)2.65066324
97protein hydroxylation (GO:0018126)2.64401701
98regulation of cholesterol storage (GO:0010885)2.64254695
99vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.62989947
100hemidesmosome assembly (GO:0031581)2.62744060
101muscle cell fate commitment (GO:0042693)2.61955578
102stress fiber assembly (GO:0043149)2.61479379
103skin morphogenesis (GO:0043589)2.60499984
104positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.60077211
105regulation of mammary gland epithelial cell proliferation (GO:0033599)2.59812497
106positive regulation of fatty acid oxidation (GO:0046321)2.58535914
107dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.58191592
108carnitine transmembrane transport (GO:1902603)2.56811683
109NLS-bearing protein import into nucleus (GO:0006607)2.56154270
110glomerular basement membrane development (GO:0032836)2.56131384
1112-oxoglutarate metabolic process (GO:0006103)2.55432633
112regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.55100148
113modulation by symbiont of host cellular process (GO:0044068)2.54506865
114cardiac muscle hypertrophy (GO:0003300)2.54136685
115adult heart development (GO:0007512)2.53630103
116activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.53601981
117regulation of NFAT protein import into nucleus (GO:0051532)2.52626668
118fibroblast migration (GO:0010761)2.52177122
119intracellular estrogen receptor signaling pathway (GO:0030520)2.51366730
120branching involved in salivary gland morphogenesis (GO:0060445)2.50168781
121regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.49272188
122skeletal muscle adaptation (GO:0043501)2.48655901
123heart morphogenesis (GO:0003007)2.48591435
124epithelial cell differentiation involved in prostate gland development (GO:0060742)2.47943820
125cell-cell junction maintenance (GO:0045217)2.47607291
126cardiac muscle tissue morphogenesis (GO:0055008)2.46773668
127positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.46382015
128skeletal muscle contraction (GO:0003009)2.45751679
129renal filtration (GO:0097205)2.45612819
130semaphorin-plexin signaling pathway (GO:0071526)2.44178733
131macroautophagy (GO:0016236)2.43721939
132striated muscle adaptation (GO:0014888)2.43179029
133carnitine transport (GO:0015879)2.42440920
134amino-acid betaine transport (GO:0015838)2.42440920
135striated muscle hypertrophy (GO:0014897)2.41517993
136regulation of ARF GTPase activity (GO:0032312)2.41515461
137retina vasculature morphogenesis in camera-type eye (GO:0061299)2.40617482
138positive regulation of nuclease activity (GO:0032075)2.40405067
139embryonic eye morphogenesis (GO:0048048)2.37411468
1403-UTR-mediated mRNA stabilization (GO:0070935)2.37038814
141negative regulation of myotube differentiation (GO:0010832)2.36275127
142desmosome organization (GO:0002934)2.35890239
143branching involved in mammary gland duct morphogenesis (GO:0060444)2.34374462
144pentose-phosphate shunt (GO:0006098)2.32298961
145response to muramyl dipeptide (GO:0032495)2.31992713
146modulation by virus of host morphology or physiology (GO:0019048)2.30722847
147response to fluid shear stress (GO:0034405)2.30535693
148cortical actin cytoskeleton organization (GO:0030866)2.28242242
149modulation by virus of host process (GO:0019054)2.26732509
150cellular response to epidermal growth factor stimulus (GO:0071364)2.25556292
151cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.25055706
152activation of JUN kinase activity (GO:0007257)2.24170932
153regulation of nucleobase-containing compound transport (GO:0032239)2.23560233
154regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.23346647
155membrane protein ectodomain proteolysis (GO:0006509)2.18294589
156response to peptidoglycan (GO:0032494)2.17498683
157endoplasmic reticulum unfolded protein response (GO:0030968)2.16888959
158regulation of integrin activation (GO:0033623)2.16492769
159embryo implantation (GO:0007566)2.16049086
160regulation of nuclease activity (GO:0032069)2.14920795
161negative regulation of viral release from host cell (GO:1902187)2.12888662
162eye morphogenesis (GO:0048592)2.12697457
163positive regulation of protein dephosphorylation (GO:0035307)2.11354589
164protein targeting to plasma membrane (GO:0072661)2.11178287
165negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)2.10857932
166Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.10518935
167embryonic camera-type eye morphogenesis (GO:0048596)2.09349451
168glucose catabolic process (GO:0006007)2.09038585
169ER-nucleus signaling pathway (GO:0006984)2.08529273
170positive regulation of extracellular matrix organization (GO:1903055)2.08335985
171glucose 6-phosphate metabolic process (GO:0051156)2.06889728
172negative regulation of skeletal muscle tissue development (GO:0048642)2.06235912
173actin filament bundle organization (GO:0061572)2.05642947
174actin filament bundle assembly (GO:0051017)2.05642947
175RNA stabilization (GO:0043489)2.04985329
176mRNA stabilization (GO:0048255)2.04985329
177regulation of chromatin binding (GO:0035561)2.04958180

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.82146082
2TP63_17297297_ChIP-ChIP_HaCaT_Human3.74849923
3NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.53473802
4* RARG_19884340_ChIP-ChIP_MEFs_Mouse3.12056913
5CLOCK_20551151_ChIP-Seq_293T_Human2.95714965
6ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.60535479
7TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.53095685
8TRIM28_21343339_ChIP-Seq_HEK293_Human2.50130510
9ZNF263_19887448_ChIP-Seq_K562_Human2.23413644
10TBX20_22080862_ChIP-Seq_HEART_Mouse2.16567050
11TBX20_22328084_ChIP-Seq_HEART_Mouse2.16567050
12ESR2_21235772_ChIP-Seq_MCF-7_Human2.15077787
13TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.14784654
14RUNX2_24764292_ChIP-Seq_MC3T3_Mouse2.12710581
15* ELK3_25401928_ChIP-Seq_HUVEC_Human2.11514317
16PPARA_22158963_ChIP-Seq_LIVER_Mouse2.11005058
17STAT6_21828071_ChIP-Seq_BEAS2B_Human2.09268380
18HIF1A_21447827_ChIP-Seq_MCF-7_Human2.08845259
19* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human2.02695307
20RXR_22158963_ChIP-Seq_LIVER_Mouse1.94598759
21LXR_22158963_ChIP-Seq_LIVER_Mouse1.94303542
22* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.89163758
23EGR1_19374776_ChIP-ChIP_THP-1_Human1.85428666
24* KDM2B_26808549_Chip-Seq_DND41_Human1.85002433
25ESR1_21235772_ChIP-Seq_MCF-7_Human1.83979700
26* SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.82825381
27* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.82751320
28* RACK7_27058665_Chip-Seq_MCF-7_Human1.82400102
29EP300_21415370_ChIP-Seq_HL-1_Mouse1.80834568
30TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.79338852
31* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.78306644
32NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.77561288
33STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.75746843
34ESR1_20079471_ChIP-ChIP_T-47D_Human1.73655362
35ATF3_27146783_Chip-Seq_COLON_Human1.68854663
36VDR_24763502_ChIP-Seq_THP-1_Human1.66947565
37* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.65375749
38FOXM1_23109430_ChIP-Seq_U2OS_Human1.63634365
39LXR_22292898_ChIP-Seq_THP-1_Human1.63177838
40* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.59323745
41ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.56529641
42PPAR_26484153_Chip-Seq_NCI-H1993_Human1.55890062
43* FOXO3_23340844_ChIP-Seq_DLD1_Human1.55853375
44* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.53994469
45* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.53992490
46TCF7_22412390_ChIP-Seq_EML_Mouse1.51872003
47TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.51471102
48SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.47351956
49ERG_21242973_ChIP-ChIP_JURKAT_Human1.44970997
50* CTCF_27219007_Chip-Seq_ERYTHROID_Human1.43623137
51THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.39809528
52CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.39501031
53MYC_22102868_ChIP-Seq_BL_Human1.39021315
54NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.37867432
55* MAF_26560356_Chip-Seq_TH1_Human1.37458498
56SMC4_20622854_ChIP-Seq_HELA_Human1.37192399
57DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.36466036
58DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.35994813
59* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.35535393
60VDR_21846776_ChIP-Seq_THP-1_Human1.35315861
61STAT3_1855785_ChIP-Seq_MESCs_Mouse1.33568517
62* ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.33272558
63TP53_22127205_ChIP-Seq_IMR90_Human1.33034377
64P68_20966046_ChIP-Seq_HELA_Human1.32670688
65* CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.32504791
66BRD4_27068464_Chip-Seq_AML-cells_Mouse1.32437212
67RUNX1_27514584_Chip-Seq_MCF-7_Human1.31787350
68ZFP281_27345836_Chip-Seq_ESCs_Mouse1.31172111
69TET1_21451524_ChIP-Seq_MESCs_Mouse1.31142378
70* KDM2B_26808549_Chip-Seq_K562_Human1.30644832
71* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.30582685
72NFIB_24661679_ChIP-Seq_LUNG_Mouse1.30363828
73* SA1_27219007_Chip-Seq_ERYTHROID_Human1.30254675
74SOX9_24532713_ChIP-Seq_HFSC_Mouse1.28697796
75RUNX1_22412390_ChIP-Seq_EML_Mouse1.28575386
76ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.28036635
77SOX2_27498859_Chip-Seq_STOMACH_Mouse1.25965386
78TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.24951928
79KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.24723745
80NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.23970311
81FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.23521333
82MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.22660374
83ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.22227685
84FOXA2_19822575_ChIP-Seq_HepG2_Human1.21927680
85E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.21126038
86* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.21112675
87NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.21052576
88UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.20318301
89UTX_26944678_Chip-Seq_JUKART_Human1.19974290
90* CREB1_26743006_Chip-Seq_LNCaP_Human1.19268503
91* GATA6_25053715_ChIP-Seq_YYC3_Human1.18943407
92VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.18211229
93TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.17818051
94TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.17203279
95* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.17002910
96* MAF_26560356_Chip-Seq_TH2_Human1.16750417
97EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.15822639
98UBF1/2_26484160_Chip-Seq_HMECs_Human1.15720885
99TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.14456052
100POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.12604349
101SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.12576447
102* KDM2B_26808549_Chip-Seq_JURKAT_Human1.12328332
103GATA1_19941827_ChIP-Seq_MEL_Mouse1.11660066
104GATA1_22383799_ChIP-Seq_G1ME_Mouse1.10862475
105SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.10221272
106SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.10221272
107NCOR1_26117541_ChIP-Seq_K562_Human1.08789363
108SALL4_18804426_ChIP-ChIP_XEN_Mouse1.08699524
109RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.08626714
110CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.08368987
111CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.07521467
112SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.06377488
113CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.06253975
114* ISL1_27105846_Chip-Seq_CPCs_Mouse1.05378127
115SPI1_23127762_ChIP-Seq_K562_Human1.04683853
116BRD4_25478319_ChIP-Seq_HGPS_Human1.03116671
117* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.02821722
118SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.02761825
119PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.02503342
120MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.02273787
121DNAJC2_21179169_ChIP-ChIP_NT2_Human1.02234632
122SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.01988906
123MYB_21317192_ChIP-Seq_ERMYB_Mouse1.01092837
124* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.00799846
125TCF3_18692474_ChIP-Seq_MEFs_Mouse0.99871720
126NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.99083514
127SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.98703920
128KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.98008356
129KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.98008356
130KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.98008356
131MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.97498512
132FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.97037080
133* CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.96800140
134* SMC1_22415368_ChIP-Seq_MEFs_Mouse0.96404815
135ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.96018176
136RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.95910417
137PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.95788035
138SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.95500726

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003705_abnormal_hypodermis_morpholog3.83173455
2MP0004084_abnormal_cardiac_muscle3.34458601
3MP0000751_myopathy3.32774599
4MP0008438_abnormal_cutaneous_collagen3.27259349
5MP0002837_dystrophic_cardiac_calcinosis3.20983218
6MP0005451_abnormal_body_composition2.67178291
7MP0000750_abnormal_muscle_regeneration2.59192716
8MP0000749_muscle_degeneration2.54511172
9MP0004087_abnormal_muscle_fiber2.47993464
10MP0004036_abnormal_muscle_relaxation2.30770937
11MP0000733_abnormal_muscle_development2.29779919
12MP0004858_abnormal_nervous_system2.24871309
13MP0003566_abnormal_cell_adhesion2.20597101
14MP0005623_abnormal_meninges_morphology2.20206613
15MP0005330_cardiomyopathy2.18984538
16MP0003646_muscle_fatigue2.15941936
17MP0005409_darkened_coat_color2.08040879
18MP0010630_abnormal_cardiac_muscle2.06547554
19MP0004130_abnormal_muscle_cell2.05490218
20MP0008260_abnormal_autophagy2.05006082
21MP0003172_abnormal_lysosome_physiology1.93714016
22MP0004185_abnormal_adipocyte_glucose1.92986935
23MP0002269_muscular_atrophy1.92319383
24MP0004272_abnormal_basement_membrane1.90376780
25MP0000747_muscle_weakness1.90189998
26MP0004233_abnormal_muscle_weight1.87897568
27MP0005666_abnormal_adipose_tissue1.82876255
28MP0002106_abnormal_muscle_physiology1.79046938
29MP0004215_abnormal_myocardial_fiber1.76880019
30MP0001348_abnormal_lacrimal_gland1.75268436
31MP0000759_abnormal_skeletal_muscle1.73810965
32MP0005275_abnormal_skin_tensile1.72513339
33MP0003279_aneurysm1.68772833
34MP0003191_abnormal_cellular_cholesterol1.64516526
35MP0003436_decreased_susceptibility_to1.64222426
36MP0005076_abnormal_cell_differentiation1.60755638
37MP0002972_abnormal_cardiac_muscle1.60419596
38MP0006138_congestive_heart_failure1.56244753
39MP0003453_abnormal_keratinocyte_physiol1.55384677
40MP0008775_abnormal_heart_ventricle1.54266138
41MP0010352_gastrointestinal_tract_polyps1.53846100
42MP0005670_abnormal_white_adipose1.52711618
43MP0005385_cardiovascular_system_phenoty1.50949133
44MP0001544_abnormal_cardiovascular_syste1.50949133
45MP0005369_muscle_phenotype1.50852676
46MP0002249_abnormal_larynx_morphology1.49628490
47MP0005620_abnormal_muscle_contractility1.49207838
48MP0005375_adipose_tissue_phenotype1.48003313
49MP0003283_abnormal_digestive_organ1.47589600
50MP0003300_gastrointestinal_ulcer1.42124028
51MP0001958_emphysema1.39416746
52MP0004145_abnormal_muscle_electrophysio1.39050884
53MP0000858_altered_metastatic_potential1.31743979
54MP0003091_abnormal_cell_migration1.31279627
55MP0003950_abnormal_plasma_membrane1.28341065
56MP0002108_abnormal_muscle_morphology1.25809469
57MP0004947_skin_inflammation1.23148798
58MP0000678_abnormal_parathyroid_gland1.22898771
59MP0004264_abnormal_extraembryonic_tissu1.22076457
60MP0000003_abnormal_adipose_tissue1.22031320
61MP0010030_abnormal_orbit_morphology1.21996821
62MP0002998_abnormal_bone_remodeling1.21671135
63MP0010234_abnormal_vibrissa_follicle1.21039642
64MP0003567_abnormal_fetal_cardiomyocyte1.21032699
65MP0003828_pulmonary_edema1.18017402
66MP0009840_abnormal_foam_cell1.17859954
67MP0009384_cardiac_valve_regurgitation1.17688145
68MP0002396_abnormal_hematopoietic_system1.17465905
69MP0009278_abnormal_bone_marrow1.17447888
70MP0004808_abnormal_hematopoietic_stem1.16868983
71MP0000767_abnormal_smooth_muscle1.15950384
72MP0003303_peritoneal_inflammation1.15776014
73MP0003137_abnormal_impulse_conducting1.13097967
74MP0001849_ear_inflammation1.13038583
75MP0002089_abnormal_postnatal_growth/wei1.12534610
76MP0005023_abnormal_wound_healing1.10370459
77MP0005503_abnormal_tendon_morphology1.10143790
78MP0000266_abnormal_heart_morphology1.08463276
79MP0003221_abnormal_cardiomyocyte_apopto1.06461552
80MP0003045_fibrosis1.05517242
81MP0002796_impaired_skin_barrier1.04068016
82MP0000537_abnormal_urethra_morphology1.03572686
83MP0005058_abnormal_lysosome_morphology1.02944825
84MP0005083_abnormal_biliary_tract1.01479380
85MP0002877_abnormal_melanocyte_morpholog0.97853770
86MP0002234_abnormal_pharynx_morphology0.96578086
87MP0002128_abnormal_blood_circulation0.95996932
88MP0004197_abnormal_fetal_growth/weight/0.94594559
89MP0003115_abnormal_respiratory_system0.94110681
90MP0005621_abnormal_cell_physiology0.93778766
91MP0010368_abnormal_lymphatic_system0.92417388
92MP0002925_abnormal_cardiovascular_devel0.90685419
93MP0004484_altered_response_of0.89995121
94MP0002896_abnormal_bone_mineralization0.89467807
95MP0001533_abnormal_skeleton_physiology0.88456011
96MP0000428_abnormal_craniofacial_morphol0.87596883
97MP0005257_abnormal_intraocular_pressure0.86054170
98MP0010307_abnormal_tumor_latency0.85927468
99MP0009780_abnormal_chondrocyte_physiolo0.84920759
100MP0002088_abnormal_embryonic_growth/wei0.84399376
101MP0003984_embryonic_growth_retardation0.84324215
102MP0005501_abnormal_skin_physiology0.83843532
103MP0008961_abnormal_basal_metabolism0.83185123
104MP0009053_abnormal_anal_canal0.82940808
105MP0002971_abnormal_brown_adipose0.81611038
106MP0004381_abnormal_hair_follicle0.81570841
107MP0003252_abnormal_bile_duct0.81410297
108MP0003183_abnormal_peptide_metabolism0.81392446
109MP0006054_spinal_hemorrhage0.80518525
110MP0001614_abnormal_blood_vessel0.79190519
111MP0005390_skeleton_phenotype0.78920696
112MP0009672_abnormal_birth_weight0.78581452
113MP0001915_intracranial_hemorrhage0.78411380
114MP0001299_abnormal_eye_distance/0.77694642
115MP0002933_joint_inflammation0.76784467
116MP0003385_abnormal_body_wall0.76166119
117MP0002332_abnormal_exercise_endurance0.75691632
118MP0009931_abnormal_skin_appearance0.75372471
119MP0002060_abnormal_skin_morphology0.73842451
120MP0004510_myositis0.73564850
121MP0003942_abnormal_urinary_system0.73387758
122MP0000467_abnormal_esophagus_morphology0.73115609
123MP0000569_abnormal_digit_pigmentation0.72668099
124MP0001672_abnormal_embryogenesis/_devel0.72473817
125MP0005380_embryogenesis_phenotype0.72473817
126MP0001730_embryonic_growth_arrest0.72329241
127MP0002419_abnormal_innate_immunity0.71806704
128MP0003329_amyloid_beta_deposits0.71632060
129MP0002086_abnormal_extraembryonic_tissu0.70019604
130MP0005508_abnormal_skeleton_morphology0.69221630
131MP0003795_abnormal_bone_structure0.68659335
132MP0002168_other_aberrant_phenotype0.68308031
133MP0001243_abnormal_dermal_layer0.68106555
134MP0000534_abnormal_ureter_morphology0.67980572
135MP0004085_abnormal_heartbeat0.67878916
136MP0002113_abnormal_skeleton_development0.67464586
137MP0002127_abnormal_cardiovascular_syste0.66939866
138MP0000013_abnormal_adipose_tissue0.66699942
139MP0000685_abnormal_immune_system0.66107812
140MP0005397_hematopoietic_system_phenotyp0.65713248
141MP0001545_abnormal_hematopoietic_system0.65713248
142MP0001873_stomach_inflammation0.64502141
143MP0001216_abnormal_epidermal_layer0.63451379
144MP0001175_abnormal_lung_morphology0.61268648

Predicted human phenotypes

RankGene SetZ-score
1Increased connective tissue (HP:0009025)4.59235172
2Muscle fiber splitting (HP:0003555)4.47861969
3Hyporeflexia of lower limbs (HP:0002600)4.40655940
4Difficulty running (HP:0009046)4.23543465
5Type 1 muscle fiber predominance (HP:0003803)4.05351748
6Sudden death (HP:0001699)4.02851079
7Exercise-induced muscle cramps (HP:0003710)3.97841677
8Right ventricular cardiomyopathy (HP:0011663)3.85570513
9Difficulty climbing stairs (HP:0003551)3.67718853
10Ventricular tachycardia (HP:0004756)3.53916553
11Exercise-induced myalgia (HP:0003738)3.51693471
12Protrusio acetabuli (HP:0003179)3.50742252
13Cerebral aneurysm (HP:0004944)3.36616724
14Calf muscle hypertrophy (HP:0008981)3.35379920
15Broad face (HP:0000283)3.33745820
16Premature rupture of membranes (HP:0001788)3.32618879
17Abnormality of the calf musculature (HP:0001430)3.31038396
18Myoglobinuria (HP:0002913)3.18181633
19Ankle contracture (HP:0006466)3.13048610
20Round ear (HP:0100830)3.11697621
21Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)3.07941096
22EMG: myopathic abnormalities (HP:0003458)3.07726688
23Muscle hypertrophy of the lower extremities (HP:0008968)3.01606579
24Muscle fiber inclusion bodies (HP:0100299)2.99825660
25Shallow orbits (HP:0000586)2.98781758
26Mildly elevated creatine phosphokinase (HP:0008180)2.97822040
27Asymmetric septal hypertrophy (HP:0001670)2.95578254
28Broad metatarsal (HP:0001783)2.91634715
29Increased variability in muscle fiber diameter (HP:0003557)2.83861558
30Scapular winging (HP:0003691)2.83605035
31Lipoatrophy (HP:0100578)2.81974538
32Abnormality of the left ventricular outflow tract (HP:0011103)2.81064466
33Subaortic stenosis (HP:0001682)2.81064466
34Obstructive sleep apnea (HP:0002870)2.76362058
35Vertebral compression fractures (HP:0002953)2.74732751
36Abnormality of skeletal muscle fiber size (HP:0012084)2.70019462
37Distal lower limb amyotrophy (HP:0008944)2.59352202
38Atrial fibrillation (HP:0005110)2.53039597
39Distal upper limb amyotrophy (HP:0007149)2.51001093
40Upper limb amyotrophy (HP:0009129)2.51001093
41Ulnar deviation of the wrist (HP:0003049)2.49463551
42Asymmetry of the thorax (HP:0001555)2.47927326
43Disproportionate tall stature (HP:0001519)2.46884922
44Spinal rigidity (HP:0003306)2.45562284
45Distal arthrogryposis (HP:0005684)2.44279043
46Aneurysm (HP:0002617)2.43259910
47Biconcave vertebral bodies (HP:0004586)2.41869648
48Lymphangioma (HP:0100764)2.37557775
49Primary atrial arrhythmia (HP:0001692)2.32580188
50Rhabdomyolysis (HP:0003201)2.32174451
51J-shaped sella turcica (HP:0002680)2.29703515
52Nemaline bodies (HP:0003798)2.28345493
53Bundle branch block (HP:0011710)2.28049718
54Hip contracture (HP:0003273)2.27798402
55Dilated cardiomyopathy (HP:0001644)2.27795890
56Supraventricular arrhythmia (HP:0005115)2.23063028
57Mitral regurgitation (HP:0001653)2.21487532
58Aortic aneurysm (HP:0004942)2.19459057
59Supraventricular tachycardia (HP:0004755)2.17371948
60Frequent falls (HP:0002359)2.16463567
61Arterial tortuosity (HP:0005116)2.15595622
62Aortic dissection (HP:0002647)2.14340650
63Wormian bones (HP:0002645)2.12781032
64Mitral valve prolapse (HP:0001634)2.11603370
65Ulnar bowing (HP:0003031)2.11460791
66Bladder diverticulum (HP:0000015)2.10856618
67Gowers sign (HP:0003391)2.09515439
68Atrioventricular block (HP:0001678)2.07911113
69Vascular tortuosity (HP:0004948)2.06706227
70Ventricular arrhythmia (HP:0004308)2.04529276
71Osteolytic defects of the phalanges of the hand (HP:0009771)2.04077849
72Osteolytic defects of the hand bones (HP:0009699)2.04077849
73* Blue sclerae (HP:0000592)2.02540714
74Limb-girdle muscle atrophy (HP:0003797)2.02320376
75Spinal cord lesions (HP:0100561)2.01236930
76Syringomyelia (HP:0003396)2.01236930
77Abnormality of the fingertips (HP:0001211)2.00584695
78Myopathic facies (HP:0002058)1.99633276
79Myotonia (HP:0002486)1.98932768
80Dysostosis multiplex (HP:0000943)1.98173243
81Abnormality of the calcaneus (HP:0008364)1.96371806
82Turricephaly (HP:0000262)1.96319529
83Distal lower limb muscle weakness (HP:0009053)1.95886705
84Atrophic scars (HP:0001075)1.95273977
85Limb-girdle muscle weakness (HP:0003325)1.94393510
86Abnormal atrioventricular conduction (HP:0005150)1.93770256
87Generalized muscle weakness (HP:0003324)1.92532385
88EMG: neuropathic changes (HP:0003445)1.92204866
89Long palpebral fissure (HP:0000637)1.91902487
90Facial diplegia (HP:0001349)1.89347378
91Heart block (HP:0012722)1.88709965
92Spondylolisthesis (HP:0003302)1.88362824
93Achilles tendon contracture (HP:0001771)1.88292866
94Genu recurvatum (HP:0002816)1.88211929
95Short nail (HP:0001799)1.87867475
96Syncope (HP:0001279)1.87498092
97Lower limb amyotrophy (HP:0007210)1.87458464
98Advanced eruption of teeth (HP:0006288)1.85958100
99Rectal prolapse (HP:0002035)1.85404654
100Wrist flexion contracture (HP:0001239)1.84244800
101Dislocated radial head (HP:0003083)1.84179767
102Long toe (HP:0010511)1.82634500
103Stridor (HP:0010307)1.82596334
104Fragile skin (HP:0001030)1.82228236
105Abnormality of the distal phalanx of the thumb (HP:0009617)1.81986578
106Increased density of long bones (HP:0006392)1.81000770
107Hemorrhage of the eye (HP:0011885)1.80929167
108Abnormality of the thoracic spine (HP:0100711)1.80461507
109Malignant hyperthermia (HP:0002047)1.78858337
110Urinary glycosaminoglycan excretion (HP:0003541)1.78569378
111Mucopolysacchariduria (HP:0008155)1.78569378
112Abnormality of the Achilles tendon (HP:0005109)1.78142904
113Palpitations (HP:0001962)1.77527389
114Calcaneovalgus deformity (HP:0001848)1.75573448
115Elbow flexion contracture (HP:0002987)1.75428573
116Nuclear cataract (HP:0100018)1.75362666
117Joint stiffness (HP:0001387)1.75160322
118Cellulitis (HP:0100658)1.74315556
119Natal tooth (HP:0000695)1.73938744
120Joint laxity (HP:0001388)1.73882440
121Abnormality of the radial head (HP:0003995)1.73062076
122Thin ribs (HP:0000883)1.71488594
123Deformed sella turcica (HP:0002681)1.70082874
124Slender build (HP:0001533)1.70019857
125Ankyloglossia (HP:0010296)1.70002149
126Dilatation of the ascending aorta (HP:0005111)1.69885138
127Hand muscle atrophy (HP:0009130)1.69818169
128Prolonged QT interval (HP:0001657)1.69369874
129Hyperacusis (HP:0010780)1.68919729
130Knee flexion contracture (HP:0006380)1.68757900
131Neck muscle weakness (HP:0000467)1.68116560
132Insomnia (HP:0100785)1.67854814
133Cervical subluxation (HP:0003308)1.67384379
134Colitis (HP:0002583)1.67277652
135Long eyelashes (HP:0000527)1.67255113
136Thin bony cortex (HP:0002753)1.67181135
137Peritonitis (HP:0002586)1.66943041
138Abnormality of the 4th metacarpal (HP:0010012)1.66162910
139Persistence of primary teeth (HP:0006335)1.66121326
140Centrally nucleated skeletal muscle fibers (HP:0003687)1.66118744
141Back pain (HP:0003418)1.66110986
142Absent phalangeal crease (HP:0006109)1.65954937
143Abnormality of oral frenula (HP:0000190)1.65681205
144Abnormality of polysaccharide metabolism (HP:0011012)1.65356105
145Abnormality of glycosaminoglycan metabolism (HP:0004371)1.65356105
146Abnormality of mucopolysaccharide metabolism (HP:0011020)1.65356105
147Proximal amyotrophy (HP:0007126)1.65180281
148Abnormality of the distal phalanges of the toes (HP:0010182)1.64688361
149Patellar dislocation (HP:0002999)1.64677135
150Interstitial pulmonary disease (HP:0006530)1.61341303
151Abnormality of dentin (HP:0010299)1.61059897
152Easy fatigability (HP:0003388)1.61039319
153Sparse lateral eyebrow (HP:0005338)1.60320920
154Bowel diverticulosis (HP:0005222)1.60032445
155Generalized amyotrophy (HP:0003700)1.58123985
156Renal duplication (HP:0000075)1.56985884
157Emphysema (HP:0002097)1.56881782
158Dysmetric saccades (HP:0000641)1.55970831

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB34.95592276
2TTN4.87669391
3PKN23.98145558
4SMG12.89381514
5PRPF4B2.84548761
6SIK12.23096804
7LATS12.20501246
8PDGFRA2.18932799
9CDK122.16617253
10ERN12.15749660
11RIPK12.13497044
12PTK62.13199721
13MAP3K102.11857973
14DMPK1.96796678
15IRAK31.93594142
16EEF2K1.92742745
17ICK1.90064225
18LMTK21.79364348
19OBSCN1.64425572
20DDR21.59144230
21EPHB11.58185788
22CAMK1D1.53159264
23MST1R1.41725295
24PAK41.40639934
25MTOR1.39286027
26PDK41.37361867
27PDK31.37361867
28PHKG11.35176287
29PHKG21.35176287
30CAMK1G1.30042102
31MAP3K131.28592961
32BMX1.28032756
33PRKD21.27230169
34NEK11.26811192
35BCKDK1.25466037
36PTK21.22490611
37EPHA21.20650515
38MARK21.19683415
39LRRK21.16522795
40MET1.16241116
41PAK21.13275761
42NME21.08070570
43EPHB21.07361437
44RPS6KA21.04597823
45RIPK41.00840990
46LATS20.99640016
47FLT30.99274275
48FGFR40.97825441
49ILK0.93445837
50ZAP700.93227444
51PDGFRB0.92463942
52CDK60.92079203
53TYK20.92019086
54TYRO30.90549707
55TESK10.89958237
56PIK3CA0.89888066
57MAP3K60.88946746
58TGFBR20.87662059
59MYLK0.86983283
60PAK30.86941814
61PRKD10.85490123
62MAP3K70.85429933
63STK30.85137023
64TAOK10.83441232
65MAP2K30.83086051
66MAP4K10.82617537
67TAOK20.81914441
68SIK20.81901633
69TBK10.81466238
70PRKD30.78796992
71PDK20.78258013
72FGFR10.76893082
73TRPM70.74281282
74DYRK1B0.74140727
75FER0.73500825
76MOS0.73398684
77NTRK10.72797352
78ROCK10.72766898
79MAP3K10.72062075
80MAP3K140.71140624
81MAP2K20.69948496
82SIK30.66151520
83RET0.64036356
84WNK40.63660969
85WNK10.63491849
86STK100.63203710
87TNK20.63086420
88BLK0.61582589
89NEK90.61454086
90CDC42BPA0.60345036
91DAPK30.59896166
92AKT20.59539766
93RPS6KA60.59516593
94MAP3K30.59276512
95PIK3CG0.58826090
96MAPK70.57897044
97JAK30.56502387
98IRAK40.56460132
99RPS6KB20.56354136
100HIPK20.56173489
101STK40.56117927
102MAPKAPK30.54545445
103MAP2K10.54368498
104PRKAA20.54269278
105MAP3K80.54073699
106CSF1R0.51289904
107CDK40.51286350
108SCYL20.50802902
109PRKAA10.50167128
110ALK0.48945820
111PDK10.48831596
112CDK70.47223273
113CSK0.45733118
114MAP3K110.45639665
115ROCK20.45361454
116TESK20.44541047
117IRAK20.44237683
118KSR20.44207909
119NEK20.43727052
120CAMKK10.43343705
121MAPKAPK20.42948999
122STK38L0.42597444
123JAK10.42315421
124PRKG20.41804722
125PTK2B0.40684364
126FGFR20.40266589
127TIE10.39817340
128ERBB20.39789430
129CHUK0.38107688
130BTK0.37392580
131GSK3A0.37208124
132BRD40.36499538
133PDPK10.36242767
134SGK30.36056476
135MAPK110.33444831
136FGFR30.33158033
137TGFBR10.31597264
138STK380.30946780
139PRKCH0.30172912
140MAPK120.29729807
141RPS6KC10.29036210
142RPS6KL10.29036210
143KDR0.28822780
144EGFR0.28317793

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000203.19053843
22-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.96993448
3Other glycan degradation_Homo sapiens_hsa005112.90972546
4Dilated cardiomyopathy_Homo sapiens_hsa054142.49234138
5Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054102.45747816
6Fatty acid degradation_Homo sapiens_hsa000712.38805071
7Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.25518954
8Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.16622846
9Fatty acid metabolism_Homo sapiens_hsa012122.02599755
10Propanoate metabolism_Homo sapiens_hsa006401.99806665
11ECM-receptor interaction_Homo sapiens_hsa045121.94517541
12Focal adhesion_Homo sapiens_hsa045101.93225947
13Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.90280374
14Lysine degradation_Homo sapiens_hsa003101.86114397
15Carbon metabolism_Homo sapiens_hsa012001.77119519
16Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.74559271
17PPAR signaling pathway_Homo sapiens_hsa033201.62321105
18Viral myocarditis_Homo sapiens_hsa054161.61529420
19Adherens junction_Homo sapiens_hsa045201.60093575
20Nitrogen metabolism_Homo sapiens_hsa009101.54910807
21Insulin resistance_Homo sapiens_hsa049311.54500069
22Proteoglycans in cancer_Homo sapiens_hsa052051.54047491
23Small cell lung cancer_Homo sapiens_hsa052221.39130992
24Adipocytokine signaling pathway_Homo sapiens_hsa049201.33461967
25Amoebiasis_Homo sapiens_hsa051461.33444924
26Central carbon metabolism in cancer_Homo sapiens_hsa052301.30097201
27* Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.28077867
28Tight junction_Homo sapiens_hsa045301.27225682
29Thyroid cancer_Homo sapiens_hsa052161.27126394
30* B cell receptor signaling pathway_Homo sapiens_hsa046621.26379352
31Pyruvate metabolism_Homo sapiens_hsa006201.26024594
32Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.24025005
33Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.23902919
34Bladder cancer_Homo sapiens_hsa052191.23178116
35Chronic myeloid leukemia_Homo sapiens_hsa052201.22935203
36Osteoclast differentiation_Homo sapiens_hsa043801.22796273
37Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.22502144
38Arginine biosynthesis_Homo sapiens_hsa002201.21963553
39Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.20178350
40Biosynthesis of amino acids_Homo sapiens_hsa012301.19204183
41mTOR signaling pathway_Homo sapiens_hsa041501.18536390
42Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.18531496
43AMPK signaling pathway_Homo sapiens_hsa041521.18434911
44Fatty acid biosynthesis_Homo sapiens_hsa000611.18407962
45Prion diseases_Homo sapiens_hsa050201.18373576
46Pentose phosphate pathway_Homo sapiens_hsa000301.15006134
47Phospholipase D signaling pathway_Homo sapiens_hsa040721.13976622
48Notch signaling pathway_Homo sapiens_hsa043301.12163442
49ErbB signaling pathway_Homo sapiens_hsa040121.11712276
50GnRH signaling pathway_Homo sapiens_hsa049121.10746799
51Estrogen signaling pathway_Homo sapiens_hsa049151.05391943
52MicroRNAs in cancer_Homo sapiens_hsa052061.05054586
53Protein digestion and absorption_Homo sapiens_hsa049741.03498755
54Fat digestion and absorption_Homo sapiens_hsa049751.01674262
55Prolactin signaling pathway_Homo sapiens_hsa049171.01394444
56Hepatitis B_Homo sapiens_hsa051610.99698939
57Choline metabolism in cancer_Homo sapiens_hsa052310.99375567
58Starch and sucrose metabolism_Homo sapiens_hsa005000.99074042
59Tryptophan metabolism_Homo sapiens_hsa003800.98839602
60Leukocyte transendothelial migration_Homo sapiens_hsa046700.98162097
61Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.97898921
62* Insulin signaling pathway_Homo sapiens_hsa049100.96921990
63Hepatitis C_Homo sapiens_hsa051600.96596817
64Hippo signaling pathway_Homo sapiens_hsa043900.96169201
65Toll-like receptor signaling pathway_Homo sapiens_hsa046200.95864942
66Leishmaniasis_Homo sapiens_hsa051400.95529148
67Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.93373311
68HIF-1 signaling pathway_Homo sapiens_hsa040660.91569064
69Cardiac muscle contraction_Homo sapiens_hsa042600.91089189
70Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.90754419
71Glucagon signaling pathway_Homo sapiens_hsa049220.89935131
72AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.88546729
73Regulation of actin cytoskeleton_Homo sapiens_hsa048100.88526672
74Basal cell carcinoma_Homo sapiens_hsa052170.88045439
75Influenza A_Homo sapiens_hsa051640.87062386
76Caffeine metabolism_Homo sapiens_hsa002320.86455835
77Colorectal cancer_Homo sapiens_hsa052100.84830022
78TNF signaling pathway_Homo sapiens_hsa046680.84398290
79Longevity regulating pathway - mammal_Homo sapiens_hsa042110.83897020
80Butanoate metabolism_Homo sapiens_hsa006500.83511067
81Renal cell carcinoma_Homo sapiens_hsa052110.83358235
82Apoptosis_Homo sapiens_hsa042100.80663099
83Bile secretion_Homo sapiens_hsa049760.80472097
84Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.80254954
85Endocytosis_Homo sapiens_hsa041440.79922911
86Thyroid hormone signaling pathway_Homo sapiens_hsa049190.79491331
87Type II diabetes mellitus_Homo sapiens_hsa049300.74136442
88* Phosphatidylinositol signaling system_Homo sapiens_hsa040700.73860717
89Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.71538768
90Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.70587314
91Dorso-ventral axis formation_Homo sapiens_hsa043200.70258046
92Cyanoamino acid metabolism_Homo sapiens_hsa004600.70206024
93Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.69484612
94Tuberculosis_Homo sapiens_hsa051520.67961438
95Pancreatic cancer_Homo sapiens_hsa052120.67807835
96Sphingolipid signaling pathway_Homo sapiens_hsa040710.67726529
97Shigellosis_Homo sapiens_hsa051310.67378892
98Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.67182450
99Toxoplasmosis_Homo sapiens_hsa051450.66584907
100Selenocompound metabolism_Homo sapiens_hsa004500.66200801
101* Inositol phosphate metabolism_Homo sapiens_hsa005620.65367698
102Melanogenesis_Homo sapiens_hsa049160.65238823
103Salmonella infection_Homo sapiens_hsa051320.62944579
104VEGF signaling pathway_Homo sapiens_hsa043700.62812338
105Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.62179884
106T cell receptor signaling pathway_Homo sapiens_hsa046600.62041029
107Endometrial cancer_Homo sapiens_hsa052130.61803802
108Malaria_Homo sapiens_hsa051440.60649159
109TGF-beta signaling pathway_Homo sapiens_hsa043500.60471686
110Glioma_Homo sapiens_hsa052140.60061845
111PI3K-Akt signaling pathway_Homo sapiens_hsa041510.59328089
112Measles_Homo sapiens_hsa051620.57768533
113Arginine and proline metabolism_Homo sapiens_hsa003300.56160446
114Galactose metabolism_Homo sapiens_hsa000520.55930551
115NF-kappa B signaling pathway_Homo sapiens_hsa040640.54728181
116Hedgehog signaling pathway_Homo sapiens_hsa043400.54265520
117Chemokine signaling pathway_Homo sapiens_hsa040620.53020917
118Prostate cancer_Homo sapiens_hsa052150.52851453
119Non-small cell lung cancer_Homo sapiens_hsa052230.52068859
120Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.51839347
121Glycerolipid metabolism_Homo sapiens_hsa005610.51331905
122Lysosome_Homo sapiens_hsa041420.50659705
123Melanoma_Homo sapiens_hsa052180.49909223
124MAPK signaling pathway_Homo sapiens_hsa040100.49545939
125Pathways in cancer_Homo sapiens_hsa052000.49490166
126Acute myeloid leukemia_Homo sapiens_hsa052210.49404377
127Pertussis_Homo sapiens_hsa051330.48866683
128Glycosaminoglycan degradation_Homo sapiens_hsa005310.48033156
129cGMP-PKG signaling pathway_Homo sapiens_hsa040220.47653386
130Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.46299524
131Platelet activation_Homo sapiens_hsa046110.45921715
132beta-Alanine metabolism_Homo sapiens_hsa004100.44544775
133Fructose and mannose metabolism_Homo sapiens_hsa000510.43692767
134Complement and coagulation cascades_Homo sapiens_hsa046100.42508496
135FoxO signaling pathway_Homo sapiens_hsa040680.40986556
136Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.40536309
137Neurotrophin signaling pathway_Homo sapiens_hsa047220.38687050
138Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.37881663
139Viral carcinogenesis_Homo sapiens_hsa052030.36619098
140Rap1 signaling pathway_Homo sapiens_hsa040150.36271847
141HTLV-I infection_Homo sapiens_hsa051660.35405902
142Carbohydrate digestion and absorption_Homo sapiens_hsa049730.34772284

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