ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	regulation of type B pancreatic cell apoptotic process (GO:2000674)	7.93250238
2	regulation of glucokinase activity (GO:0033131)	7.02678204
3	regulation of hexokinase activity (GO:1903299)	7.02678204
4	regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:1902235	6.53773722
5	negative regulation of hormone biosynthetic process (GO:0032353)	6.12432394
6	lactate metabolic process (GO:0006089)	5.85805816
7	nitric oxide mediated signal transduction (GO:0007263)	5.72555271
8	* endocrine pancreas development (GO:0031018)	5.53523061
9	negative regulation of hormone metabolic process (GO:0032351)	5.31136853
10	type B pancreatic cell development (GO:0003323)	5.24532766
11	insulin secretion (GO:0030073)	5.11978192
12	chemosensory behavior (GO:0007635)	4.99405830
13	positive regulation of insulin secretion (GO:0032024)	4.75627423
14	positive regulation of growth hormone secretion (GO:0060124)	4.75521304
15	negative regulation of Ras GTPase activity (GO:0034261)	4.72142039
16	nucleoside diphosphate catabolic process (GO:0009134)	4.67830614
17	inositol phosphate catabolic process (GO:0071545)	4.57883441
18	cellular ketone body metabolic process (GO:0046950)	4.55177510
19	detection of calcium ion (GO:0005513)	4.52083871
20	* positive regulation of peptide hormone secretion (GO:0090277)	4.43152061
21	negative regulation of inflammatory response to antigenic stimulus (GO:0002862)	4.41714367
22	histamine secretion (GO:0001821)	4.40002327
23	* positive regulation of glycolytic process (GO:0045821)	4.35282325
24	glandular epithelial cell differentiation (GO:0002067)	4.33911792
25	* positive regulation of peptide secretion (GO:0002793)	4.26350192
26	negative regulation of neurological system process (GO:0031645)	4.23667648
27	inositol phosphate dephosphorylation (GO:0046855)	4.19204991
28	phosphorylated carbohydrate dephosphorylation (GO:0046838)	4.19204991
29	positive regulation of calcium ion-dependent exocytosis (GO:0045956)	4.13995061
30	signal peptide processing (GO:0006465)	4.09311888
31	ketone body metabolic process (GO:1902224)	4.02206422
32	dendritic spine morphogenesis (GO:0060997)	3.95460012
33	negative regulation of glial cell proliferation (GO:0060253)	3.91969515
34	regulation of glucocorticoid metabolic process (GO:0031943)	3.90553573
35	regulation of energy homeostasis (GO:2000505)	3.85088522
36	glandular epithelial cell development (GO:0002068)	3.79241328
37	* regulation of insulin secretion (GO:0050796)	3.78520548
38	response to lipoprotein particle (GO:0055094)	3.77942997
39	regulation of steroid hormone biosynthetic process (GO:0090030)	3.64364556
40	positive regulation of macroautophagy (GO:0016239)	3.60045113
41	* regulation of peptide hormone secretion (GO:0090276)	3.59621703
42	response to glucose (GO:0009749)	3.57973001
43	exocrine pancreas development (GO:0031017)	3.55731906
44	polyol catabolic process (GO:0046174)	3.54594232
45	righting reflex (GO:0060013)	3.53516660
46	peptide hormone processing (GO:0016486)	3.52580031
47	peptide hormone secretion (GO:0030072)	3.52380258
48	* regulation of peptide secretion (GO:0002791)	3.51644732
49	water-soluble vitamin biosynthetic process (GO:0042364)	3.50939656
50	histamine transport (GO:0051608)	3.40183463
51	regulation of acute inflammatory response to antigenic stimulus (GO:0002864)	3.39632181
52	response to hexose (GO:0009746)	3.39455462
53	negative regulation of cytosolic calcium ion concentration (GO:0051481)	3.38602309
54	* positive regulation of hormone secretion (GO:0046887)	3.37833063
55	peptide secretion (GO:0002790)	3.37301407
56	cellular response to vitamin D (GO:0071305)	3.33909423
57	protein targeting to Golgi (GO:0000042)	3.33595844
58	response to hepatocyte growth factor (GO:0035728)	3.32883336
59	cellular response to hepatocyte growth factor stimulus (GO:0035729)	3.32883336
60	positive regulation of response to nutrient levels (GO:0032109)	3.32269790
61	positive regulation of response to extracellular stimulus (GO:0032106)	3.32269790
62	regulation of growth hormone secretion (GO:0060123)	3.32148287
63	epithelial cell fate commitment (GO:0072148)	3.28879703
64	* negative regulation of acute inflammatory response (GO:0002674)	3.28779413
65	L-alpha-amino acid transmembrane transport (GO:1902475)	3.22624417
66	kidney morphogenesis (GO:0060993)	3.21515403
67	response to monosaccharide (GO:0034284)	3.20614869
68	* regulation of hormone secretion (GO:0046883)	3.16797326
69	establishment of protein localization to Golgi (GO:0072600)	3.15866934
70	macroautophagy (GO:0016236)	3.15710614
71	negative regulation of bone resorption (GO:0045779)	3.15182365
72	zinc ion homeostasis (GO:0055069)	3.14052788
73	fructose metabolic process (GO:0006000)	3.10226633
74	keratinocyte development (GO:0003334)	3.09779693
75	retrograde transport, vesicle recycling within Golgi (GO:0000301)	3.06732254
76	positive regulation of TOR signaling (GO:0032008)	3.05566161
77	cellular zinc ion homeostasis (GO:0006882)	3.01240438
78	protein localization to Golgi apparatus (GO:0034067)	2.98158553
79	calcium ion import (GO:0070509)	2.97720350
80	prostate gland growth (GO:0060736)	2.97353495
81	positive regulation of Rap GTPase activity (GO:0032854)	2.97329584
82	glycerophospholipid catabolic process (GO:0046475)	2.94904649
83	mesenchymal cell differentiation involved in renal system development (GO:2001012)	2.94613443
84	mesenchymal cell differentiation involved in kidney development (GO:0072161)	2.94613443
85	startle response (GO:0001964)	2.93141342
86	regulation of calcium ion-dependent exocytosis (GO:0017158)	2.89495667
87	negative regulation of catecholamine secretion (GO:0033604)	2.86072802
88	negative regulation of insulin secretion (GO:0046676)	2.85384785
89	* regulation of peptide transport (GO:0090087)	2.84870989
90	hormone secretion (GO:0046879)	2.83995242
91	regulation of protein glycosylation (GO:0060049)	2.82560958
92	respiratory chain complex IV assembly (GO:0008535)	2.79350457
93	positive regulation of neurotransmitter transport (GO:0051590)	2.76520824
94	zinc ion transmembrane transport (GO:0071577)	2.76376378
95	intra-Golgi vesicle-mediated transport (GO:0006891)	2.75376038
96	regulation of transmission of nerve impulse (GO:0051969)	2.74163804
97	positive regulation of meiosis (GO:0045836)	2.72800875
98	peptide transport (GO:0015833)	2.72142995
99	columnar/cuboidal epithelial cell development (GO:0002066)	2.69197717
100	zinc ion transport (GO:0006829)	2.69028541

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	7.67586972
2	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	3.70911153
3	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	2.94636372
4	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.61003336
5	ZNF274_21170338_ChIP-Seq_K562_Hela	2.17701572
6	GBX2_23144817_ChIP-Seq_PC3_Human	2.16799139
7	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.99297368
8	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	1.90600706
9	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.89866755
10	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.87502488
11	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.85783644
12	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.74646739
13	SMAD4_21799915_ChIP-Seq_A2780_Human	1.66991254
14	AR_25329375_ChIP-Seq_VCAP_Human	1.60897399
15	HTT_18923047_ChIP-ChIP_STHdh_Human	1.60018750
16	IGF1R_20145208_ChIP-Seq_DFB_Human	1.59757263
17	P300_19829295_ChIP-Seq_ESCs_Human	1.59541124
18	CDX2_19796622_ChIP-Seq_MESCs_Mouse	1.57038953
19	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.55068343
20	REST_21632747_ChIP-Seq_MESCs_Mouse	1.52366552
21	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.52352839
22	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.51706589
23	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.51278131
24	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.48776977
25	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.48202358
26	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.48125912
27	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.47384294
28	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.46517326
29	ER_23166858_ChIP-Seq_MCF-7_Human	1.45609431
30	TP53_22573176_ChIP-Seq_HFKS_Human	1.42921757
31	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.41546992
32	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.38354703
33	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.37160039
34	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.35601205
35	CBP_20019798_ChIP-Seq_JUKART_Human	1.35601205
36	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.33929409
37	* CDX2_22108803_ChIP-Seq_LS180_Human	1.33826994
38	STAT3_23295773_ChIP-Seq_U87_Human	1.33050509
39	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.32964873
40	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.32842865
41	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.32280159
42	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.31394956
43	CMYC_18555785_Chip-Seq_ESCs_Mouse	1.30882851
44	P53_22387025_ChIP-Seq_ESCs_Mouse	1.30301339
45	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.28497723
46	FUS_26573619_Chip-Seq_HEK293_Human	1.28297922
47	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.27145801
48	VDR_22108803_ChIP-Seq_LS180_Human	1.26398670
49	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.25866403
50	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.24091245
51	TCF4_23295773_ChIP-Seq_U87_Human	1.24066150
52	NR3C1_23031785_ChIP-Seq_PC12_Mouse	1.23107579
53	ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.22584827
54	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.20530443
55	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.19612601
56	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.18986700
57	SOX2_19829295_ChIP-Seq_ESCs_Human	1.17420894
58	NANOG_19829295_ChIP-Seq_ESCs_Human	1.17420894
59	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.17315875
60	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.17017322
61	STAT3_18555785_Chip-Seq_ESCs_Mouse	1.16812629
62	EWS_26573619_Chip-Seq_HEK293_Human	1.16627147
63	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.14955090
64	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.14584714
65	TAF15_26573619_Chip-Seq_HEK293_Human	1.14329051
66	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.13741091
67	SUZ12_18555785_Chip-Seq_ESCs_Mouse	1.13511830
68	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.13408261
69	* BCAT_22108803_ChIP-Seq_LS180_Human	1.13307204
70	TFEB_21752829_ChIP-Seq_HELA_Human	1.12275556
71	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.12042280
72	FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human	1.11962338
73	P300_18555785_Chip-Seq_ESCs_Mouse	1.11830763
74	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.11678478
75	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.11678478
76	CTCF_18555785_Chip-Seq_ESCs_Mouse	1.10580925
77	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.09758704
78	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	1.09421289
79	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.09277268
80	E2F1_18555785_Chip-Seq_ESCs_Mouse	1.08875170
81	HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse	1.06112756
82	EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse	1.05563137
83	SUZ12_20075857_ChIP-Seq_MESCs_Mouse	1.05324726
84	AR_20517297_ChIP-Seq_VCAP_Human	1.05315654
85	SOX2_18555785_Chip-Seq_ESCs_Mouse	1.05284520
86	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.05212551
87	ZNF217_24962896_ChIP-Seq_MCF-7_Human	1.04748678
88	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.04279520
89	TBL1_22424771_ChIP-Seq_293T_Human	1.04239851
90	OCT4_21477851_ChIP-Seq_ESCs_Mouse	1.02854067
91	SOX2_21211035_ChIP-Seq_LN229_Gbm	1.02447182
92	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.00808718
93	PRDM14_20953172_ChIP-Seq_ESCs_Human	0.99585357
94	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	0.98908273
95	TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse	0.98873329
96	NFYB_21822215_ChIP-Seq_K562_Human	0.98181032
97	RUNX2_22187159_ChIP-Seq_PCA_Human	0.97872519
98	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	0.97732175
99	NOTCH1_21737748_ChIP-Seq_TLL_Human	0.97330565
100	* TCF4_22108803_ChIP-Seq_LS180_Human	0.97007561

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003195_calcinosis	6.02412395
2	MP0003283_abnormal_digestive_organ	5.39979418
3	MP0003787_abnormal_imprinting	4.89660141
4	MP0010234_abnormal_vibrissa_follicle	4.57959233
5	MP0003123_paternal_imprinting	3.82222929
6	MP0002909_abnormal_adrenal_gland	3.39678258
7	MP0003122_maternal_imprinting	3.37837002
8	MP0009780_abnormal_chondrocyte_physiolo	3.23414011
9	MP0002837_dystrophic_cardiac_calcinosis	3.02887841
10	MP0002693_abnormal_pancreas_physiology	2.94714566
11	MP0002163_abnormal_gland_morphology	2.94339637
12	MP0001944_abnormal_pancreas_morphology	2.88766806
13	MP0005379_endocrine/exocrine_gland_phen	2.58182146
14	MP0008877_abnormal_DNA_methylation	2.56105850
15	MP0005220_abnormal_exocrine_pancreas	2.17313848
16	MP0002822_catalepsy	2.14006811
17	MP0003121_genomic_imprinting	2.12739067
18	MP0002928_abnormal_bile_duct	1.95754389
19	MP0005645_abnormal_hypothalamus_physiol	1.94874009
20	MP0002078_abnormal_glucose_homeostasis	1.84959132
21	MP0002102_abnormal_ear_morphology	1.83745496
22	MP0002876_abnormal_thyroid_physiology	1.80668401
23	MP0009046_muscle_twitch	1.77857282
24	MP0000462_abnormal_digestive_system	1.77521309
25	MP0000013_abnormal_adipose_tissue	1.75417825
26	MP0001984_abnormal_olfaction	1.72745807
27	MP0003172_abnormal_lysosome_physiology	1.59499461
28	MP0000516_abnormal_urinary_system	1.59463838
29	MP0005367_renal/urinary_system_phenotyp	1.59463838
30	MP0005646_abnormal_pituitary_gland	1.55775637
31	MP0006072_abnormal_retinal_apoptosis	1.54676363
32	MP0010352_gastrointestinal_tract_polyps	1.54485881
33	MP0010678_abnormal_skin_adnexa	1.49347721
34	MP0002090_abnormal_vision	1.42756407
35	MP0002638_abnormal_pupillary_reflex	1.36030926
36	MP0004043_abnormal_pH_regulation	1.34350177
37	MP0001756_abnormal_urination	1.28156943
38	MP0000427_abnormal_hair_cycle	1.22606600
39	MP0002277_abnormal_respiratory_mucosa	1.21536821
40	MP0010386_abnormal_urinary_bladder	1.21009697
41	MP0001986_abnormal_taste_sensitivity	1.19770603
42	MP0004510_myositis	1.16204983
43	MP0003953_abnormal_hormone_level	1.14205976
44	MP0005448_abnormal_energy_balance	1.12549719
45	MP0003011_delayed_dark_adaptation	1.10740623
46	MP0000569_abnormal_digit_pigmentation	1.08676769
47	MP0001727_abnormal_embryo_implantation	1.06253348
48	MP0001765_abnormal_ion_homeostasis	1.05866673
49	MP0010329_abnormal_lipoprotein_level	1.05302677
50	MP0005332_abnormal_amino_acid	1.04741261
51	MP0005636_abnormal_mineral_homeostasis	1.00106144
52	MP0000003_abnormal_adipose_tissue	1.00008015
53	MP0004270_analgesia	0.98713486
54	MP0005535_abnormal_body_temperature	0.95659161
55	MP0003633_abnormal_nervous_system	0.95477198
56	MP0005551_abnormal_eye_electrophysiolog	0.94651620
57	MP0002160_abnormal_reproductive_system	0.94638512
58	MP0009745_abnormal_behavioral_response	0.93760252
59	MP0002118_abnormal_lipid_homeostasis	0.93315311
60	MP0009643_abnormal_urine_homeostasis	0.93229536
61	MP0004885_abnormal_endolymph	0.91177605
62	MP0003045_fibrosis	0.90846726
63	MP0005075_abnormal_melanosome_morpholog	0.90376959
64	MP0002064_seizures	0.90314118
65	MP0005253_abnormal_eye_physiology	0.87829118
66	MP0001440_abnormal_grooming_behavior	0.86547568
67	MP0005386_behavior/neurological_phenoty	0.81953319
68	MP0004924_abnormal_behavior	0.81953319
69	MP0001661_extended_life_span	0.81121106
70	MP0004134_abnormal_chest_morphology	0.79853332
71	MP0002557_abnormal_social/conspecific_i	0.79673937
72	MP0006036_abnormal_mitochondrial_physio	0.79331451
73	MP0002938_white_spotting	0.78665067
74	MP0005389_reproductive_system_phenotype	0.78411846
75	MP0000639_abnormal_adrenal_gland	0.75312302
76	MP0000678_abnormal_parathyroid_gland	0.75092753
77	MP0002229_neurodegeneration	0.74383965
78	MP0001905_abnormal_dopamine_level	0.73913218
79	MP0002572_abnormal_emotion/affect_behav	0.73411252
80	MP0002168_other_aberrant_phenotype	0.72068050
81	MP0004142_abnormal_muscle_tone	0.70370339
82	MP0002272_abnormal_nervous_system	0.70333344
83	MP0005452_abnormal_adipose_tissue	0.69436073
84	MP0000631_abnormal_neuroendocrine_gland	0.69270857
85	MP0002166_altered_tumor_susceptibility	0.67593585
86	MP0003868_abnormal_feces_composition	0.63277999
87	MP0000538_abnormal_urinary_bladder	0.62225912
88	MP0003252_abnormal_bile_duct	0.62213998
89	MP0008872_abnormal_physiological_respon	0.60814902
90	MP0002069_abnormal_eating/drinking_beha	0.59715140
91	MP0004859_abnormal_synaptic_plasticity	0.58520243
92	MP0002295_abnormal_pulmonary_circulatio	0.58061359
93	MP0000383_abnormal_hair_follicle	0.56777948
94	MP0003943_abnormal_hepatobiliary_system	0.56722864
95	MP0009642_abnormal_blood_homeostasis	0.56342223
96	MP0005365_abnormal_bile_salt	0.56311091
97	MP0002971_abnormal_brown_adipose	0.55613180
98	MP0010307_abnormal_tumor_latency	0.55449710
99	MP0003119_abnormal_digestive_system	0.53365715
100	MP0003635_abnormal_synaptic_transmissio	0.49886962

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Hypoglycemic coma (HP:0001325)	9.19706194
2	Symptomatic seizures (HP:0011145)	7.75504661
3	* Ketoacidosis (HP:0001993)	5.14478785
4	Large for gestational age (HP:0001520)	4.90131165
5	Hypomagnesemia (HP:0002917)	4.86062213
6	Insulin-resistant diabetes mellitus (HP:0000831)	4.66981408
7	Late onset (HP:0003584)	4.63491564
8	Elevated circulating parathyroid hormone (PTH) level (HP:0003165)	4.56651637
9	Pancreatic islet-cell hyperplasia (HP:0004510)	4.27657632
10	* Abnormality of endocrine pancreas physiology (HP:0012093)	4.20198463
11	* Abnormality of the pancreatic islet cells (HP:0006476)	4.20198463
12	Hypothermia (HP:0002045)	4.10130375
13	* Hyperglycemia (HP:0003074)	4.00728370
14	Increased circulating renin level (HP:0000848)	3.92713144
15	Abnormality of magnesium homeostasis (HP:0004921)	3.87174163
16	Enlarged penis (HP:0000040)	3.79692224
17	Neoplasm of the adrenal cortex (HP:0100641)	3.71558837
18	Abnormal pancreas size (HP:0012094)	3.60317896
19	* Prominent metopic ridge (HP:0005487)	3.16546344
20	* Ketosis (HP:0001946)	3.14907337
21	Hyperphosphatemia (HP:0002905)	3.06249885
22	Hypokinesia (HP:0002375)	3.04104444
23	Hyperthyroidism (HP:0000836)	3.00472065
24	* EEG with generalized epileptiform discharges (HP:0011198)	2.83154544
25	* Abnormality of the metopic suture (HP:0005556)	2.80033176
26	* Epileptiform EEG discharges (HP:0011182)	2.80002964
27	Tongue fasciculations (HP:0001308)	2.71975296
28	Hamartoma of the eye (HP:0010568)	2.71474945
29	Hematochezia (HP:0002573)	2.71120136
30	Insulin resistance (HP:0000855)	2.68081668
31	Metaphyseal dysplasia (HP:0100255)	2.60873440
32	* Hypsarrhythmia (HP:0002521)	2.60307431
33	Polydipsia (HP:0001959)	2.59642076
34	Abnormal drinking behavior (HP:0030082)	2.59642076
35	Conjunctival hamartoma (HP:0100780)	2.59229704
36	Tetany (HP:0001281)	2.56193015
37	Testicular neoplasm (HP:0010788)	2.46072766
38	Abnormal sex determination (HP:0012244)	2.35704158
39	Sex reversal (HP:0012245)	2.35704158
40	Hepatoblastoma (HP:0002884)	2.35497499
41	Abnormality of calcium-phosphate metabolism (HP:0100530)	2.34727137
42	Hepatic necrosis (HP:0002605)	2.33224126
43	Muscle fibrillation (HP:0010546)	2.31397531
44	Hemiparesis (HP:0001269)	2.30055507
45	Calf muscle hypertrophy (HP:0008981)	2.24773670
46	Agitation (HP:0000713)	2.24594625
47	Neoplasm of the adrenal gland (HP:0100631)	2.18443902
48	Villous atrophy (HP:0011473)	2.16710804
49	Abnormality of small intestinal villus morphology (HP:0011472)	2.16710804
50	Asymmetry of the thorax (HP:0001555)	2.15833048
51	Diminished movement (HP:0002374)	2.13534732
52	Macroorchidism (HP:0000053)	2.13227957
53	Methylmalonic acidemia (HP:0002912)	2.12559763
54	Lower limb hyperreflexia (HP:0002395)	2.04551199
55	Cutaneous melanoma (HP:0012056)	2.01729217
56	Abnormality of renin-angiotensin system (HP:0000847)	2.01538858
57	Hypoglycemic seizures (HP:0002173)	11.3675411
58	Hyperinsulinemic hypoglycemia (HP:0000825)	10.0334186
59	Basal ganglia calcification (HP:0002135)	1.98359637
60	Thyroiditis (HP:0100646)	1.98298805
61	Muscle hypertrophy of the lower extremities (HP:0008968)	1.93739276
62	Progressive macrocephaly (HP:0004481)	1.90916696
63	Unilateral renal agenesis (HP:0000122)	1.89566235
64	* Muscular hypotonia of the trunk (HP:0008936)	1.84995878
65	Ventricular fibrillation (HP:0001663)	1.83959534
66	* Downturned corners of mouth (HP:0002714)	1.83846865
67	Febrile seizures (HP:0002373)	1.83173934
68	Abnormality of the basal ganglia (HP:0002134)	1.80514503
69	Abnormality of aromatic amino acid family metabolism (HP:0004338)	1.77405001
70	Tachypnea (HP:0002789)	1.76687124
71	Increased density of long bones (HP:0006392)	1.75623901
72	Aqueductal stenosis (HP:0002410)	1.74828419
73	Acute hepatic failure (HP:0006554)	1.73844658
74	Epileptic encephalopathy (HP:0200134)	1.73731781
75	Stridor (HP:0010307)	1.68018458
76	Furrowed tongue (HP:0000221)	1.68005662
77	Dicarboxylic aciduria (HP:0003215)	1.67097030
78	Abnormality of dicarboxylic acid metabolism (HP:0010995)	1.67097030
79	Lymphangioma (HP:0100764)	1.65444329
80	Polyuria (HP:0000103)	1.64043894
81	Thyroid carcinoma (HP:0002890)	1.63339752
82	Abnormality of vitamin B metabolism (HP:0004340)	1.59023639
83	Neonatal hypoglycemia (HP:0001998)	1.58219422
84	Myoglobinuria (HP:0002913)	1.53012304
85	Hyperphosphaturia (HP:0003109)	1.52923822
86	Abnormal albumin level (HP:0012116)	1.52382847
87	Hypoalbuminemia (HP:0003073)	1.52382847
88	Malnutrition (HP:0004395)	1.51232201
89	Hyperparathyroidism (HP:0000843)	1.50410339
90	Methylmalonic aciduria (HP:0012120)	1.50306749
91	Adrenal hypoplasia (HP:0000835)	1.49663110
92	Menstrual irregularities (HP:0000858)	1.49130167
93	Intention tremor (HP:0002080)	1.48953040
94	Septate vagina (HP:0001153)	1.48610631
95	Hypobetalipoproteinemia (HP:0003563)	1.47672463
96	Disproportionate short-trunk short stature (HP:0003521)	1.47487295
97	Abnormality of methionine metabolism (HP:0010901)	1.45726299
98	Aplasia/hypoplasia of the uterus (HP:0008684)	1.45566324
99	Exocrine pancreatic insufficiency (HP:0001738)	1.44238527
100	Delayed gross motor development (HP:0002194)	1.43672036

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	9.54919268
2	PASK	5.21662252
3	FGFR2	5.08175295
4	MAP3K2	2.88517898
5	NTRK3	2.57108478
6	FGFR3	2.51646649
7	PHKG2	2.14864250
8	PHKG1	2.14864250
9	DAPK2	2.12421596
10	NLK	1.84800169
11	HIPK2	1.72914644
12	TRIM28	1.61363062
13	TNIK	1.46855002
14	MAP4K2	1.37632150
15	PAK3	1.36659899
16	BMPR1B	1.34031314
17	MAP3K1	1.29135611
18	PRKAA2	1.27558898
19	PNCK	1.22882226
20	STK38L	1.21184597
21	ADRBK2	1.20562012
22	AKT3	1.18581130
23	FER	1.12310703
24	MAP3K4	1.09214363
25	INSRR	1.08113506
26	GRK1	1.06534009
27	CSNK1G1	1.04877020
28	TRPM7	1.04863041
29	PRKAA1	1.03486534
30	MST4	1.00117689
31	CASK	0.95684008
32	PRKCG	0.91837218
33	WNK3	0.90198754
34	PINK1	0.88430620
35	STK24	0.87858580
36	STK3	0.87215377
37	MAP2K6	0.84383959
38	STK11	0.82720324
39	STK39	0.82533910
40	PLK3	0.81790225
41	CSNK1G3	0.81471406
42	LIMK1	0.81180625
43	TAOK1	0.81048261
44	NUAK1	0.79267928
45	EPHA3	0.79037997
46	ACVR1B	0.78134471
47	SGK2	0.76732737
48	OXSR1	0.75171530
49	CSNK1G2	0.73627166
50	IRAK1	0.73484506
51	MAP3K7	0.72991682
52	PLK2	0.72705017
53	STK16	0.72209256
54	EIF2AK3	0.70041260
55	PRKCE	0.67597451
56	CAMK1G	0.64291909
57	ERBB3	0.63180293
58	PTK2B	0.62195190
59	CAMK2D	0.61306929
60	MAP2K7	0.59443245
61	WNK4	0.55544418
62	CDK3	0.53280730
63	SGK494	0.49968296
64	SGK223	0.49968296
65	YES1	0.48386295
66	IRAK2	0.44853335
67	SGK3	0.44616871
68	TSSK6	0.44203241
69	MAP3K9	0.43094036
70	PRKCZ	0.39147149
71	CAMK1	0.36125295
72	PRKACA	0.35736598
73	EIF2AK1	0.34658514
74	DAPK1	0.33586653
75	PTK2	0.33333882
76	SGK1	0.33302855
77	ADRBK1	0.32785794
78	TESK1	0.29924834
79	PRKCA	0.29679654
80	ZAK	0.28998003
81	JAK1	0.27740257
82	STK4	0.27612655
83	CSNK1A1	0.27129021
84	PRKG1	0.26137065
85	PRKCH	0.25721395
86	ROCK1	0.25408016
87	CSNK1D	0.23328744
88	IKBKB	0.23167608
89	PRKD2	0.22563548
90	CAMK2A	0.21976842
91	GSK3A	0.21453174
92	ATM	0.20800016
93	CDC42BPA	0.19790789
94	IRAK4	0.19291478
95	CHUK	0.18823875
96	CSNK1A1L	0.18356996
97	UHMK1	0.17140462
98	CSNK1E	0.17006118
99	CDK5	0.16573051
100	OBSCN	0.15695619

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	* Maturity onset diabetes of the young_Homo sapiens_hsa04950	8.78232820
2	Butanoate metabolism_Homo sapiens_hsa00650	3.51544407
3	Protein export_Homo sapiens_hsa03060	3.47739736
4	* Insulin secretion_Homo sapiens_hsa04911	3.31670262
5	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.49278164
6	Collecting duct acid secretion_Homo sapiens_hsa04966	2.44790579
7	Fatty acid elongation_Homo sapiens_hsa00062	2.42994873
8	* Type II diabetes mellitus_Homo sapiens_hsa04930	2.39467188
9	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	2.29522225
10	Vitamin B6 metabolism_Homo sapiens_hsa00750	2.15856758
11	Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524	1.97268435
12	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.74999024
13	Synaptic vesicle cycle_Homo sapiens_hsa04721	1.63264967
14	Fatty acid metabolism_Homo sapiens_hsa01212	1.60822727
15	Sulfur metabolism_Homo sapiens_hsa00920	1.59922346
16	Tryptophan metabolism_Homo sapiens_hsa00380	1.55583678
17	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	1.49883791
18	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	1.41397671
19	Vibrio cholerae infection_Homo sapiens_hsa05110	1.38246437
20	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.26192758
21	Fatty acid degradation_Homo sapiens_hsa00071	1.25912382
22	Circadian rhythm_Homo sapiens_hsa04710	1.22774229
23	* Type I diabetes mellitus_Homo sapiens_hsa04940	1.20548012
24	Renin secretion_Homo sapiens_hsa04924	1.19819148
25	Oxidative phosphorylation_Homo sapiens_hsa00190	1.15476180
26	Selenocompound metabolism_Homo sapiens_hsa00450	1.13390166
27	ABC transporters_Homo sapiens_hsa02010	1.09720481
28	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	1.06096237
29	Propanoate metabolism_Homo sapiens_hsa00640	1.05252056
30	Mineral absorption_Homo sapiens_hsa04978	1.02343802
31	Peroxisome_Homo sapiens_hsa04146	1.01117134
32	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.95995527
33	* mTOR signaling pathway_Homo sapiens_hsa04150	0.93724990
34	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.91085847
35	* Regulation of autophagy_Homo sapiens_hsa04140	0.88664402
36	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.87741691
37	beta-Alanine metabolism_Homo sapiens_hsa00410	0.84863031
38	Amphetamine addiction_Homo sapiens_hsa05031	0.84220606
39	Glucagon signaling pathway_Homo sapiens_hsa04922	0.83316742
40	Pancreatic secretion_Homo sapiens_hsa04972	0.77887094
41	Sphingolipid metabolism_Homo sapiens_hsa00600	0.76315311
42	Thyroid hormone synthesis_Homo sapiens_hsa04918	0.75013118
43	Phototransduction_Homo sapiens_hsa04744	0.74936937
44	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.71201360
45	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	0.69625515
46	Galactose metabolism_Homo sapiens_hsa00052	0.68310913
47	Salivary secretion_Homo sapiens_hsa04970	0.68027578
48	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.67557906
49	Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961	0.66634660
50	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.66608491
51	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.66581865
52	Folate biosynthesis_Homo sapiens_hsa00790	0.66136949
53	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.64550438
54	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.64209312
55	Ether lipid metabolism_Homo sapiens_hsa00565	0.64174665
56	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.62070461
57	Lysine degradation_Homo sapiens_hsa00310	0.61964136
58	* Insulin resistance_Homo sapiens_hsa04931	0.61019303
59	Circadian entrainment_Homo sapiens_hsa04713	0.58721902
60	Dopaminergic synapse_Homo sapiens_hsa04728	0.57335139
61	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.53827344
62	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.52563741
63	* AMPK signaling pathway_Homo sapiens_hsa04152	0.49160887
64	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.47987105
65	Bile secretion_Homo sapiens_hsa04976	0.47379983
66	* Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.47086027
67	Cocaine addiction_Homo sapiens_hsa05030	0.47051386
68	Steroid biosynthesis_Homo sapiens_hsa00100	0.46841227
69	Lysosome_Homo sapiens_hsa04142	0.44985385
70	Cardiac muscle contraction_Homo sapiens_hsa04260	0.44828190
71	Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120	0.43638000
72	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.43059689
73	Linoleic acid metabolism_Homo sapiens_hsa00591	0.42955522
74	Fructose and mannose metabolism_Homo sapiens_hsa00051	0.42871182
75	Serotonergic synapse_Homo sapiens_hsa04726	0.41941837
76	Long-term depression_Homo sapiens_hsa04730	0.40390172
77	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.40143354
78	Metabolic pathways_Homo sapiens_hsa01100	0.37333046
79	Rheumatoid arthritis_Homo sapiens_hsa05323	0.34536768
80	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.34237318
81	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	0.33666682
82	* Ovarian steroidogenesis_Homo sapiens_hsa04913	0.33497549
83	Taste transduction_Homo sapiens_hsa04742	0.33188819
84	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.32702581
85	Glutamatergic synapse_Homo sapiens_hsa04724	0.30338216
86	Inositol phosphate metabolism_Homo sapiens_hsa00562	0.30026253
87	GABAergic synapse_Homo sapiens_hsa04727	0.29940166
88	Caffeine metabolism_Homo sapiens_hsa00232	0.29850599
89	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.29785726
90	Retinol metabolism_Homo sapiens_hsa00830	0.28423965
91	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.28274704
92	RNA degradation_Homo sapiens_hsa03018	0.27627023
93	Glycosaminoglycan degradation_Homo sapiens_hsa00531	0.27541929
94	Nicotine addiction_Homo sapiens_hsa05033	0.26845537
95	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.26153028
96	Adipocytokine signaling pathway_Homo sapiens_hsa04920	0.25571678
97	* cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.25250363
98	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.23544509
99	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.23431095
100	Alzheimers disease_Homo sapiens_hsa05010	0.23353835

INS

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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