ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	omega-hydroxylase P450 pathway (GO:0097267)	7.22834844
2	exogenous drug catabolic process (GO:0042738)	6.59074149
3	epoxygenase P450 pathway (GO:0019373)	6.50015866
4	complement activation, alternative pathway (GO:0006957)	6.42294467
5	drug catabolic process (GO:0042737)	6.35948350
6	regulation of protein activation cascade (GO:2000257)	6.00581684
7	erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)	5.90019222
8	L-phenylalanine catabolic process (GO:0006559)	5.90019222
9	regulation of fibrinolysis (GO:0051917)	5.82099843
10	regulation of complement activation (GO:0030449)	5.82037685
11	positive regulation of glycolytic process (GO:0045821)	5.53644292
12	protein carboxylation (GO:0018214)	5.38135841
13	peptidyl-glutamic acid carboxylation (GO:0017187)	5.38135841
14	fatty acid homeostasis (GO:0055089)	5.32990852
15	L-phenylalanine metabolic process (GO:0006558)	5.22666006
16	erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)	5.22666006
17	glyoxylate metabolic process (GO:0046487)	5.06290420
18	negative regulation of fibrinolysis (GO:0051918)	4.95148158
19	cellular ketone body metabolic process (GO:0046950)	4.77972435
20	negative regulation of gluconeogenesis (GO:0045721)	4.74532948
21	negative regulation of acute inflammatory response (GO:0002674)	4.67597366
22	ethanol oxidation (GO:0006069)	4.64053680
23	positive regulation of respiratory burst (GO:0060267)	4.63533904
24	oxidative demethylation (GO:0070989)	4.63519777
25	imidazole-containing compound metabolic process (GO:0052803)	4.54108406
26	blood coagulation, intrinsic pathway (GO:0007597)	4.51651814
27	regulation of glucokinase activity (GO:0033131)	4.49066713
28	regulation of hexokinase activity (GO:1903299)	4.49066713
29	endocrine pancreas development (GO:0031018)	4.45638930
30	phenylpropanoid metabolic process (GO:0009698)	4.39685672
31	aromatic amino acid family catabolic process (GO:0009074)	4.38195057
32	acute-phase response (GO:0006953)	4.34772571
33	drug metabolic process (GO:0017144)	4.31637565
34	fibrinolysis (GO:0042730)	4.28956613
35	ketone body metabolic process (GO:1902224)	4.18610813
36	regulation of type B pancreatic cell apoptotic process (GO:2000674)	4.15879450
37	protein activation cascade (GO:0072376)	4.14299620
38	urea metabolic process (GO:0019627)	4.12166648
39	serine family amino acid catabolic process (GO:0009071)	4.04675532
40	complement activation, classical pathway (GO:0006958)	4.03435113
41	nitric oxide mediated signal transduction (GO:0007263)	4.01232220
42	bile acid biosynthetic process (GO:0006699)	4.00895240
43	positive regulation of glycogen biosynthetic process (GO:0045725)	3.98011238
44	triglyceride-rich lipoprotein particle remodeling (GO:0034370)	3.95251250
45	acylglycerol homeostasis (GO:0055090)	3.94007291
46	triglyceride homeostasis (GO:0070328)	3.94007291
47	complement activation (GO:0006956)	3.89897667
48	negative regulation of protein oligomerization (GO:0032460)	3.88826647
49	positive regulation of insulin receptor signaling pathway (GO:0046628)	3.81840431
50	negative regulation of cholesterol transport (GO:0032375)	3.81006448
51	negative regulation of sterol transport (GO:0032372)	3.81006448
52	nitrogen cycle metabolic process (GO:0071941)	3.76392919
53	negative regulation of glycogen metabolic process (GO:0070874)	3.72005414
54	regulation of triglyceride catabolic process (GO:0010896)	3.69652896
55	negative regulation of protein activation cascade (GO:2000258)	3.68459268
56	regulation of plasminogen activation (GO:0010755)	3.66889525
57	opsonization (GO:0008228)	3.65102175
58	S-adenosylmethionine metabolic process (GO:0046500)	3.61819368
59	ethanol metabolic process (GO:0006067)	3.61000940
60	high-density lipoprotein particle remodeling (GO:0034375)	3.60540598
61	regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:1902235	3.58762081
62	urea cycle (GO:0000050)	3.49297844
63	regulation of humoral immune response (GO:0002920)	3.47270743
64	positive regulation of glycogen metabolic process (GO:0070875)	3.45813075
65	glutamate metabolic process (GO:0006536)	3.45106185
66	exocrine pancreas development (GO:0031017)	3.43217353
67	cellular glucuronidation (GO:0052695)	3.37342995
68	positive regulation of peptide hormone secretion (GO:0090277)	3.34619115
69	protein-lipid complex remodeling (GO:0034368)	3.34564419
70	macromolecular complex remodeling (GO:0034367)	3.34564419
71	plasma lipoprotein particle remodeling (GO:0034369)	3.34564419
72	lactate metabolic process (GO:0006089)	3.34021516
73	bile acid metabolic process (GO:0008206)	3.30712569
74	negative regulation of hemostasis (GO:1900047)	3.30667318
75	negative regulation of blood coagulation (GO:0030195)	3.30667318
76	cholesterol efflux (GO:0033344)	3.26244147
77	uronic acid metabolic process (GO:0006063)	3.24869779
78	glucuronate metabolic process (GO:0019585)	3.24869779
79	regulation of acute inflammatory response (GO:0002673)	3.23622567
80	positive regulation of peptide secretion (GO:0002793)	3.21177048
81	reverse cholesterol transport (GO:0043691)	3.19391632
82	negative regulation of complement activation (GO:0045916)	3.18526111
83	xenobiotic catabolic process (GO:0042178)	3.18069016
84	tyrosine metabolic process (GO:0006570)	3.14967182
85	acute inflammatory response (GO:0002526)	3.13954149
86	negative regulation of wound healing (GO:0061045)	3.09245966
87	regulation of cholesterol esterification (GO:0010872)	3.07106331
88	alpha-amino acid catabolic process (GO:1901606)	3.06612815
89	negative regulation of coagulation (GO:0050819)	3.06378217
90	positive regulation of protein autophosphorylation (GO:0031954)	3.05555896
91	intestinal cholesterol absorption (GO:0030299)	3.04584001
92	indolalkylamine catabolic process (GO:0046218)	3.03240243
93	tryptophan catabolic process (GO:0006569)	3.03240243
94	indole-containing compound catabolic process (GO:0042436)	3.03240243
95	L-alpha-amino acid transmembrane transport (GO:1902475)	3.01695394
96	cytolysis (GO:0019835)	2.99505578
97	fructose metabolic process (GO:0006000)	2.99284447
98	negative regulation of hormone biosynthetic process (GO:0032353)	2.97942654
99	regulation of glycolytic process (GO:0006110)	2.96763793
100	positive regulation of cellular response to insulin stimulus (GO:1900078)	2.95287906

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	4.85610124
2	ESR1_17901129_ChIP-ChIP_LIVER_Mouse	4.77104087
3	EGR1_23403033_ChIP-Seq_LIVER_Mouse	3.86392752
4	RXR_22158963_ChIP-Seq_LIVER_Mouse	3.68758282
5	LXR_22158963_ChIP-Seq_LIVER_Mouse	3.33610124
6	FOXO1_23066095_ChIP-Seq_LIVER_Mouse	3.30816691
7	PPARA_22158963_ChIP-Seq_LIVER_Mouse	2.95932364
8	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	2.71364895
9	NR1I2_20693526_ChIP-Seq_LIVER_Mouse	2.62016588
10	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	2.50702733
11	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	2.37352399
12	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	2.22199209
13	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.08649356
14	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.91803939
15	HTT_18923047_ChIP-ChIP_STHdh_Human	1.91537791
16	GBX2_23144817_ChIP-Seq_PC3_Human	1.88368831
17	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.86641779
18	BCAT_22108803_ChIP-Seq_LS180_Human	1.69317722
19	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.64621511
20	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.61147342
21	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.52995282
22	CDX2_19796622_ChIP-Seq_MESCs_Mouse	1.51709091
23	FOXA2_19822575_ChIP-Seq_HepG2_Human	1.45473114
24	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.38527578
25	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.35628667
26	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.32694948
27	SMAD4_21799915_ChIP-Seq_A2780_Human	1.31136961
28	ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.31008604
29	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	1.27988388
30	CDX2_22108803_ChIP-Seq_LS180_Human	1.27224547
31	AR_25329375_ChIP-Seq_VCAP_Human	1.27166493
32	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.24039292
33	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.21472910
34	TCF7L2_21901280_ChIP-Seq_H4IIE_Rat	1.20988917
35	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.18662012
36	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.17794263
37	PPARG_19300518_ChIP-PET_3T3-L1_Mouse	1.17661913
38	ER_23166858_ChIP-Seq_MCF-7_Human	1.17312767
39	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.16547337
40	CBP_20019798_ChIP-Seq_JUKART_Human	1.16212093
41	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.16212093
42	HNF4A_19822575_ChIP-Seq_HepG2_Human	1.16204023
43	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	1.15775757
44	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.15434169
45	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.14676086
46	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.13978959
47	STAT3_23295773_ChIP-Seq_U87_Human	1.13704199
48	AR_20517297_ChIP-Seq_VCAP_Human	1.11964124
49	CBP_21632823_ChIP-Seq_H3396_Human	1.11562067
50	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.09493825
51	AR_21915096_ChIP-Seq_LNCaP-1F5_Human	1.09244014
52	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.09143401
53	ZNF217_24962896_ChIP-Seq_MCF-7_Human	1.08913796
54	FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human	1.08678869
55	TCF4_23295773_ChIP-Seq_U87_Human	1.08546754
56	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.08199833
57	P300_19829295_ChIP-Seq_ESCs_Human	1.07903371
58	ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse	1.07634826
59	IGF1R_20145208_ChIP-Seq_DFB_Human	1.07519302
60	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.06892273
61	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.06786373
62	NR3C1_23031785_ChIP-Seq_PC12_Mouse	1.05839562
63	P53_22387025_ChIP-Seq_ESCs_Mouse	1.05198994
64	CMYC_18555785_Chip-Seq_ESCs_Mouse	1.04394320
65	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.04226409
66	ZNF274_21170338_ChIP-Seq_K562_Hela	1.04011268
67	STAT3_18555785_Chip-Seq_ESCs_Mouse	1.02177946
68	BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human	1.01569121
69	SUZ12_20075857_ChIP-Seq_MESCs_Mouse	1.00949935
70	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.00873571
71	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.00074325
72	RUNX2_22187159_ChIP-Seq_PCA_Human	0.99988625
73	EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse	0.99769337
74	FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	0.99619549
75	TCF4_22108803_ChIP-Seq_LS180_Human	0.99066355
76	REST_21632747_ChIP-Seq_MESCs_Mouse	0.98600472
77	SMAD4_21741376_ChIP-Seq_EPCs_Human	0.98076046
78	CTCF_18555785_Chip-Seq_ESCs_Mouse	0.97492889
79	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	0.97253731
80	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	0.96955107
81	FLI1_27457419_Chip-Seq_LIVER_Mouse	0.96735638
82	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.96714135
83	NR3C1_21868756_ChIP-Seq_MCF10A_Human	0.96640572
84	BMI1_23680149_ChIP-Seq_NPCS_Mouse	0.95286501
85	NANOG_19829295_ChIP-Seq_ESCs_Human	0.94779189
86	SOX2_19829295_ChIP-Seq_ESCs_Human	0.94779189
87	PU1_27457419_Chip-Seq_LIVER_Mouse	0.94753552
88	OCT4_21477851_ChIP-Seq_ESCs_Mouse	0.94740561
89	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	0.94409701
90	E2F1_18555785_Chip-Seq_ESCs_Mouse	0.94389267
91	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	0.94034714
92	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	0.93876381
93	SMAD3_21741376_ChIP-Seq_EPCs_Human	0.93719053
94	P300_18555785_Chip-Seq_ESCs_Mouse	0.93717369
95	FOXA1_25552417_ChIP-Seq_VCAP_Human	0.93054224
96	ESR1_22446102_ChIP-Seq_UTERUS_Mouse	0.92318435
97	AHR_22903824_ChIP-Seq_MCF-7_Human	0.92287905
98	SUZ12_18555785_Chip-Seq_ESCs_Mouse	0.91314760
99	PHF8_20622853_ChIP-Seq_HELA_Human	0.91247035
100	VDR_22108803_ChIP-Seq_LS180_Human	0.90966761

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003195_calcinosis	7.78463349
2	MP0002139_abnormal_hepatobiliary_system	5.97734133
3	MP0005365_abnormal_bile_salt	3.92291336
4	MP0003283_abnormal_digestive_organ	3.82816116
5	MP0005085_abnormal_gallbladder_physiolo	3.64167626
6	MP0008875_abnormal_xenobiotic_pharmacok	3.44620386
7	MP0005360_urolithiasis	3.17928615
8	MP0003252_abnormal_bile_duct	2.97415493
9	MP0002909_abnormal_adrenal_gland	2.96617176
10	MP0002138_abnormal_hepatobiliary_system	2.88255307
11	MP0003122_maternal_imprinting	2.76474509
12	MP0003787_abnormal_imprinting	2.53454127
13	MP0010329_abnormal_lipoprotein_level	2.51642772
14	MP0003123_paternal_imprinting	2.32949121
15	MP0010234_abnormal_vibrissa_follicle	2.29004467
16	MP0005332_abnormal_amino_acid	2.24332630
17	MP0003868_abnormal_feces_composition	2.13647953
18	MP0001944_abnormal_pancreas_morphology	2.09296448
19	MP0002876_abnormal_thyroid_physiology	2.06388480
20	MP0001666_abnormal_nutrient_absorption	2.05074641
21	MP0009780_abnormal_chondrocyte_physiolo	1.98823985
22	MP0005379_endocrine/exocrine_gland_phen	1.88132038
23	MP0002693_abnormal_pancreas_physiology	1.81802431
24	MP0005220_abnormal_exocrine_pancreas	1.80063637
25	MP0001661_extended_life_span	1.77321125
26	MP0002837_dystrophic_cardiac_calcinosis	1.66948427
27	MP0002928_abnormal_bile_duct	1.64525221
28	MP0002118_abnormal_lipid_homeostasis	1.64371549
29	MP0002078_abnormal_glucose_homeostasis	1.62114617
30	MP0000013_abnormal_adipose_tissue	1.59338846
31	MP0009840_abnormal_foam_cell	1.58458534
32	MP0002163_abnormal_gland_morphology	1.55760561
33	MP0010368_abnormal_lymphatic_system	1.45829597
34	MP0009697_abnormal_copulation	1.32323247
35	MP0000609_abnormal_liver_physiology	1.31736229
36	MP0002638_abnormal_pupillary_reflex	1.29743495
37	MP0009643_abnormal_urine_homeostasis	1.23686149
38	MP0005645_abnormal_hypothalamus_physiol	1.20449044
39	MP0004510_myositis	1.18592041
40	MP0004019_abnormal_vitamin_homeostasis	1.18498483
41	MP0005448_abnormal_energy_balance	1.15535060
42	MP0002822_catalepsy	1.14053757
43	MP0000462_abnormal_digestive_system	1.12424264
44	MP0003011_delayed_dark_adaptation	1.12093617
45	MP0005636_abnormal_mineral_homeostasis	1.11192948
46	MP0002168_other_aberrant_phenotype	1.08994525
47	MP0001756_abnormal_urination	1.07454173
48	MP0000003_abnormal_adipose_tissue	1.03651890
49	MP0008872_abnormal_physiological_respon	0.98057550
50	MP0003121_genomic_imprinting	0.98011224
51	MP0008877_abnormal_DNA_methylation	0.96503137
52	MP0002971_abnormal_brown_adipose	0.95169279
53	MP0010386_abnormal_urinary_bladder	0.94970596
54	MP0003879_abnormal_hair_cell	0.94769591
55	MP0005535_abnormal_body_temperature	0.93908856
56	MP0001986_abnormal_taste_sensitivity	0.93711253
57	MP0003172_abnormal_lysosome_physiology	0.93282332
58	MP0001764_abnormal_homeostasis	0.93161469
59	MP0005319_abnormal_enzyme/_coenzyme	0.93053746
60	MP0003953_abnormal_hormone_level	0.90488441
61	MP0000639_abnormal_adrenal_gland	0.90423859
62	MP0005167_abnormal_blood-brain_barrier	0.89040579
63	MP0009642_abnormal_blood_homeostasis	0.87426643
64	MP0001984_abnormal_olfaction	0.86579731
65	MP0003075_altered_response_to	0.86540492
66	MP0003656_abnormal_erythrocyte_physiolo	0.85612713
67	MP0005646_abnormal_pituitary_gland	0.85163668
68	MP0003045_fibrosis	0.82715537
69	MP0003690_abnormal_glial_cell	0.82253632
70	MP0003633_abnormal_nervous_system	0.80476990
71	MP0002295_abnormal_pulmonary_circulatio	0.80439695
72	MP0003191_abnormal_cellular_cholesterol	0.80303089
73	MP0002102_abnormal_ear_morphology	0.79332286
74	MP0000598_abnormal_liver_morphology	0.76044047
75	MP0009046_muscle_twitch	0.75306179
76	MP0002090_abnormal_vision	0.75219735
77	MP0004133_heterotaxia	0.74622792
78	MP0000678_abnormal_parathyroid_gland	0.73520276
79	MP0005395_other_phenotype	0.72560239
80	MP0005266_abnormal_metabolism	0.65441499
81	MP0010678_abnormal_skin_adnexa	0.63311477
82	MP0004043_abnormal_pH_regulation	0.62300107
83	MP0005376_homeostasis/metabolism_phenot	0.58354937
84	MP0005084_abnormal_gallbladder_morpholo	0.57479673
85	MP0005551_abnormal_eye_electrophysiolog	0.56872422
86	MP0008775_abnormal_heart_ventricle	0.55321349
87	MP0003943_abnormal_hepatobiliary_system	0.55106300
88	MP0005670_abnormal_white_adipose	0.53346147
89	MP0006036_abnormal_mitochondrial_physio	0.52366775
90	MP0006072_abnormal_retinal_apoptosis	0.51771206
91	MP0002108_abnormal_muscle_morphology	0.50896688
92	MP0001765_abnormal_ion_homeostasis	0.49418243
93	MP0000230_abnormal_systemic_arterial	0.49173933
94	MP0001440_abnormal_grooming_behavior	0.47480619
95	MP0005367_renal/urinary_system_phenotyp	0.47146628
96	MP0000516_abnormal_urinary_system	0.47146628
97	MP0005334_abnormal_fat_pad	0.46463521
98	MP0001727_abnormal_embryo_implantation	0.46426240
99	MP0002136_abnormal_kidney_physiology	0.46078220
100	MP0002132_abnormal_respiratory_system	0.45752679

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Hypoglycemic seizures (HP:0002173)	7.93606892
2	Hyperinsulinemic hypoglycemia (HP:0000825)	6.99619307
3	Hypoglycemic coma (HP:0001325)	6.74241669
4	Complement deficiency (HP:0004431)	6.51799927
5	Ketoacidosis (HP:0001993)	6.18942156
6	Prolonged partial thromboplastin time (HP:0003645)	6.00411326
7	Abnormality of aromatic amino acid family metabolism (HP:0004338)	5.86795535
8	Abnormality of the pancreatic islet cells (HP:0006476)	5.66657708
9	Abnormality of endocrine pancreas physiology (HP:0012093)	5.66657708
10	Hyperglycemia (HP:0003074)	5.41813971
11	Deep venous thrombosis (HP:0002625)	5.18081297
12	Abnormality of monocarboxylic acid metabolism (HP:0010996)	5.14077163
13	Hypobetalipoproteinemia (HP:0003563)	5.12494438
14	Symptomatic seizures (HP:0011145)	5.11386359
15	Abnormality of complement system (HP:0005339)	4.87061907
16	Joint hemorrhage (HP:0005261)	4.59035497
17	Ketosis (HP:0001946)	4.53528869
18	Late onset (HP:0003584)	4.33252794
19	Hyperlipoproteinemia (HP:0010980)	4.13007275
20	Systemic lupus erythematosus (HP:0002725)	4.10207268
21	Glomerulonephritis (HP:0000099)	3.96349623
22	Conjugated hyperbilirubinemia (HP:0002908)	3.80059106
23	Large for gestational age (HP:0001520)	3.71028753
24	Xanthomatosis (HP:0000991)	3.69196163
25	Prominent metopic ridge (HP:0005487)	3.67946837
26	Insulin-resistant diabetes mellitus (HP:0000831)	3.55193734
27	Pancreatic islet-cell hyperplasia (HP:0004510)	3.53010981
28	EEG with generalized epileptiform discharges (HP:0011198)	3.28777098
29	Hypothermia (HP:0002045)	3.27441549
30	Epileptiform EEG discharges (HP:0011182)	3.24173355
31	Abnormality of the metopic suture (HP:0005556)	3.22688801
32	Abnormality of the intrinsic pathway (HP:0010989)	3.20982482
33	Hypsarrhythmia (HP:0002521)	3.20168188
34	Intrahepatic cholestasis (HP:0001406)	3.12483737
35	Elevated circulating parathyroid hormone (PTH) level (HP:0003165)	2.94487074
36	Abnormality of methionine metabolism (HP:0010901)	2.90339775
37	Hypolipoproteinemia (HP:0010981)	2.86022011
38	Type I diabetes mellitus (HP:0100651)	2.79915171
39	Hypomagnesemia (HP:0002917)	2.74532710
40	Recurrent gram-negative bacterial infections (HP:0005420)	2.59640837
41	Neonatal hypoglycemia (HP:0001998)	2.59158427
42	Abnormality of the level of lipoprotein cholesterol (HP:0010979)	2.54314325
43	Nephritis (HP:0000123)	2.48084095
44	Increased circulating renin level (HP:0000848)	2.47878132
45	Asymmetry of the thorax (HP:0001555)	2.47721013
46	Abnormal pancreas size (HP:0012094)	2.42585493
47	Mitral stenosis (HP:0001718)	2.41254826
48	Fair hair (HP:0002286)	2.40487403
49	Enlarged penis (HP:0000040)	2.40268418
50	Insulin resistance (HP:0000855)	2.34193894
51	Fat malabsorption (HP:0002630)	2.31973154
52	Abnormality of the common coagulation pathway (HP:0010990)	2.30838404
53	Abnormality of glutamine family amino acid metabolism (HP:0010902)	2.25967751
54	Abnormality of aspartate family amino acid metabolism (HP:0010899)	2.24293912
55	Hypoalphalipoproteinemia (HP:0003233)	2.17382764
56	Abnormality of magnesium homeostasis (HP:0004921)	2.08419700
57	Hyperphosphaturia (HP:0003109)	2.07010284
58	Spontaneous abortion (HP:0005268)	2.06523246
59	Vascular calcification (HP:0004934)	2.05936866
60	Steatorrhea (HP:0002570)	2.01957811
61	Hyperphosphatemia (HP:0002905)	2.00272962
62	Abnormality of pyrimidine metabolism (HP:0004353)	1.99659528
63	Enlarged kidneys (HP:0000105)	1.96699336
64	Lymphangioma (HP:0100764)	1.93799081
65	Abnormality of sulfur amino acid metabolism (HP:0004339)	1.87430309
66	Neoplasm of the adrenal cortex (HP:0100641)	1.86268383
67	Hypokinesia (HP:0002375)	1.82747814
68	Hepatoblastoma (HP:0002884)	1.82339563
69	Abnormality of vitamin metabolism (HP:0100508)	1.80399869
70	Cardiovascular calcification (HP:0011915)	1.79760338
71	Epidermoid cyst (HP:0200040)	1.78349689
72	Generalized aminoaciduria (HP:0002909)	1.77402694
73	Abnormality of calcium-phosphate metabolism (HP:0100530)	1.76755804
74	Downturned corners of mouth (HP:0002714)	1.76528447
75	Hyperthyroidism (HP:0000836)	1.73858781
76	Abnormality of urine glucose concentration (HP:0011016)	1.73000766
77	Glycosuria (HP:0003076)	1.73000766
78	Delayed CNS myelination (HP:0002188)	1.72472878
79	Muscular hypotonia of the trunk (HP:0008936)	1.71988002
80	Hypercholesterolemia (HP:0003124)	1.71806566
81	Blue irides (HP:0000635)	1.71632434
82	Hyperglycinemia (HP:0002154)	1.69542538
83	Hematochezia (HP:0002573)	1.69254214
84	Hydroxyprolinuria (HP:0003080)	1.69247149
85	Abnormality of proline metabolism (HP:0010907)	1.69247149
86	Hepatic necrosis (HP:0002605)	1.68653875
87	Lower limb hyperreflexia (HP:0002395)	1.66763748
88	Metaphyseal dysplasia (HP:0100255)	1.64848470
89	Gout (HP:0001997)	1.64031254
90	Megaloblastic anemia (HP:0001889)	1.63435645
91	Polydipsia (HP:0001959)	1.62399745
92	Abnormal drinking behavior (HP:0030082)	1.62399745
93	Conjunctival hamartoma (HP:0100780)	1.60909851
94	Generalized hypopigmentation of hair (HP:0011358)	1.59658191
95	Hamartoma of the eye (HP:0010568)	1.59149978
96	Gingival bleeding (HP:0000225)	1.55441693
97	Hyperammonemia (HP:0001987)	1.54652512
98	Abnormal urine phosphate concentration (HP:0012599)	1.53062054
99	Abnormality of serine family amino acid metabolism (HP:0010894)	1.52187273
100	Abnormality of glycine metabolism (HP:0010895)	1.52187273

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	8.11226025
2	PASK	4.84218574
3	FGFR2	4.68178979
4	NTRK3	2.75166021
5	MAP3K2	2.73576578
6	TIE1	2.62209417
7	FGFR3	2.62203987
8	DAPK2	2.35038803
9	NLK	2.16061863
10	BMPR1B	1.88750927
11	PRKAA2	1.82556027
12	FGFR4	1.81414504
13	HIPK2	1.79491466
14	PHKG2	1.75746890
15	PHKG1	1.75746890
16	FER	1.64871250
17	EPHA3	1.54432909
18	GRK1	1.48591702
19	TRPM7	1.43559576
20	INSRR	1.37046236
21	ADRBK2	1.34933309
22	PRKAA1	1.28500158
23	MAP3K1	1.28285532
24	PTK2B	1.21601625
25	ERN1	1.18304618
26	MAP4K2	1.14778442
27	PRKCG	1.07150144
28	AKT3	1.05356208
29	MAP2K6	1.04702253
30	STK39	1.00942089
31	IRAK1	1.00803705
32	PAK3	0.97569189
33	KIT	0.87258415
34	TNIK	0.86873440
35	CSNK1G1	0.86819075
36	SGK2	0.86435240
37	MAP3K7	0.86393010
38	STK11	0.83979248
39	MAPK11	0.81721654
40	SGK223	0.80006921
41	SGK494	0.80006921
42	STK38L	0.79607160
43	WNK4	0.76691193
44	LIMK1	0.76354827
45	NUAK1	0.72880248
46	ACVR1B	0.72190977
47	KDR	0.67448748
48	PRKCE	0.63333731
49	TAOK3	0.61482307
50	WNK3	0.60761424
51	CAMK2D	0.60191344
52	PTK2	0.59596901
53	TYK2	0.59522798
54	PIK3CG	0.59415021
55	MAP3K4	0.59327451
56	PINK1	0.58683859
57	PRKACG	0.58402351
58	ABL2	0.57989485
59	OXSR1	0.56362682
60	JAK1	0.56194722
61	ADRBK1	0.54415249
62	STK3	0.53488213
63	EPHB1	0.53037125
64	PRKACA	0.52835376
65	SGK3	0.51470188
66	PRKCZ	0.50991542
67	LMTK2	0.50823096
68	CASK	0.49877098
69	BCKDK	0.49223036
70	CAMK1G	0.47661269
71	PRKG1	0.45403994
72	CSNK1G3	0.45049643
73	SGK1	0.44320891
74	GSK3A	0.41683659
75	PRKCA	0.39507424
76	CDK3	0.38050621
77	PLK2	0.37078573
78	MAP2K4	0.36020673
79	TAOK1	0.35386745
80	CSNK1G2	0.34829673
81	STK38	0.33769836
82	PNCK	0.33621330
83	OBSCN	0.33514799
84	CSNK1D	0.29694896
85	ROCK1	0.29046882
86	TRIM28	0.28521562
87	MAPK7	0.28042930
88	PIK3CA	0.26834844
89	PRKG2	0.26467493
90	CHUK	0.25899715
91	PRKACB	0.25862479
92	IGF1R	0.25452775
93	RPS6KA3	0.24704737
94	PDGFRA	0.22079002
95	TEC	0.21791474
96	PDGFRB	0.21698887
97	MAP2K7	0.21107798
98	DAPK1	0.21081533
99	MAPK1	0.20891113
100	CSNK1A1	0.20534056

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Maturity onset diabetes of the young_Homo sapiens_hsa04950	6.02014751
2	Complement and coagulation cascades_Homo sapiens_hsa04610	3.51832652
3	Caffeine metabolism_Homo sapiens_hsa00232	3.22056576
4	Butanoate metabolism_Homo sapiens_hsa00650	3.09470520
5	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	3.00050206
6	Primary bile acid biosynthesis_Homo sapiens_hsa00120	2.90614459
7	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	2.61258719
8	Retinol metabolism_Homo sapiens_hsa00830	2.60853697
9	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	2.48993879
10	Fatty acid degradation_Homo sapiens_hsa00071	2.48252330
11	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	2.15614143
12	Tryptophan metabolism_Homo sapiens_hsa00380	2.11811383
13	Chemical carcinogenesis_Homo sapiens_hsa05204	2.10992096
14	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	2.06351318
15	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	2.05842786
16	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.86751454
17	Arginine biosynthesis_Homo sapiens_hsa00220	1.80388606
18	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.77725041
19	Histidine metabolism_Homo sapiens_hsa00340	1.74160903
20	Vitamin B6 metabolism_Homo sapiens_hsa00750	1.73246010
21	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	1.73105380
22	Tyrosine metabolism_Homo sapiens_hsa00350	1.72262245
23	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.68358074
24	Bile secretion_Homo sapiens_hsa04976	1.63421264
25	Insulin secretion_Homo sapiens_hsa04911	1.62078767
26	Type II diabetes mellitus_Homo sapiens_hsa04930	1.56832778
27	Phenylalanine metabolism_Homo sapiens_hsa00360	1.52173364
28	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	1.50773944
29	Linoleic acid metabolism_Homo sapiens_hsa00591	1.50025666
30	Drug metabolism - other enzymes_Homo sapiens_hsa00983	1.45184036
31	beta-Alanine metabolism_Homo sapiens_hsa00410	1.37424275
32	Peroxisome_Homo sapiens_hsa04146	1.28336759
33	Starch and sucrose metabolism_Homo sapiens_hsa00500	1.27633407
34	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	1.27120169
35	ABC transporters_Homo sapiens_hsa02010	1.25926001
36	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.18246094
37	Protein export_Homo sapiens_hsa03060	1.14411261
38	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.10959628
39	Fatty acid metabolism_Homo sapiens_hsa01212	1.08054849
40	PPAR signaling pathway_Homo sapiens_hsa03320	1.01147707
41	Propanoate metabolism_Homo sapiens_hsa00640	0.99953863
42	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.98671214
43	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.98518160
44	Fatty acid elongation_Homo sapiens_hsa00062	0.97709379
45	One carbon pool by folate_Homo sapiens_hsa00670	0.94422494
46	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.91741490
47	Regulation of autophagy_Homo sapiens_hsa04140	0.90819358
48	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.90580782
49	Sulfur metabolism_Homo sapiens_hsa00920	0.87928644
50	Prion diseases_Homo sapiens_hsa05020	0.82038019
51	Insulin resistance_Homo sapiens_hsa04931	0.77042910
52	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.68076514
53	Type I diabetes mellitus_Homo sapiens_hsa04940	0.67869302
54	Arginine and proline metabolism_Homo sapiens_hsa00330	0.66827579
55	Lysine degradation_Homo sapiens_hsa00310	0.65803981
56	Pyruvate metabolism_Homo sapiens_hsa00620	0.63525222
57	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.62253466
58	Glucagon signaling pathway_Homo sapiens_hsa04922	0.59933727
59	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.57799164
60	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.57558560
61	Collecting duct acid secretion_Homo sapiens_hsa04966	0.57349560
62	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	0.57225891
63	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.54786414
64	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.53229905
65	Circadian rhythm_Homo sapiens_hsa04710	0.51959922
66	AMPK signaling pathway_Homo sapiens_hsa04152	0.51909048
67	Fat digestion and absorption_Homo sapiens_hsa04975	0.51063735
68	mTOR signaling pathway_Homo sapiens_hsa04150	0.49313004
69	Carbon metabolism_Homo sapiens_hsa01200	0.48264888
70	Metabolic pathways_Homo sapiens_hsa01100	0.43371591
71	Selenocompound metabolism_Homo sapiens_hsa00450	0.42473462
72	Fructose and mannose metabolism_Homo sapiens_hsa00051	0.36706058
73	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.36413322
74	Renin secretion_Homo sapiens_hsa04924	0.35393104
75	Glycosaminoglycan degradation_Homo sapiens_hsa00531	0.33341653
76	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.32861575
77	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.30853543
78	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	0.29601827
79	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.29057365
80	Mineral absorption_Homo sapiens_hsa04978	0.27954951
81	Adipocytokine signaling pathway_Homo sapiens_hsa04920	0.27789601
82	Galactose metabolism_Homo sapiens_hsa00052	0.22947784
83	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.22381076
84	Vibrio cholerae infection_Homo sapiens_hsa05110	0.21650844
85	Thyroid hormone synthesis_Homo sapiens_hsa04918	0.21443445
86	Folate biosynthesis_Homo sapiens_hsa00790	0.21230678
87	Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524	0.19457406
88	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.19407937
89	Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923	0.15666398
90	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.15582177
91	Insulin signaling pathway_Homo sapiens_hsa04910	0.15159477
92	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.14542809
93	Nitrogen metabolism_Homo sapiens_hsa00910	0.12940762
94	Sphingolipid metabolism_Homo sapiens_hsa00600	0.12328925
95	Serotonergic synapse_Homo sapiens_hsa04726	0.12008080
96	Glycerolipid metabolism_Homo sapiens_hsa00561	0.10857332
97	Pertussis_Homo sapiens_hsa05133	0.10794799
98	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.09346312
99	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.08948632
100	Pancreatic secretion_Homo sapiens_hsa04972	0.07004062

INS-IGF2

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »