INSC

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: In Drosophila, neuroblasts divide asymmetrically into another neuroblast at the apical side and a smaller ganglion mother cell on the basal side. Cell polarization is precisely regulated by 2 apically localized multiprotein signaling complexes that are tethered by Inscuteable, which regulates their apical localization (Izaki et al., 2006 [PubMed 16458856]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1central nervous system myelination (GO:0022010)8.93891713
2axon ensheathment in central nervous system (GO:0032291)8.93891713
3fatty acid elongation (GO:0030497)7.84587022
4behavioral response to nicotine (GO:0035095)6.65553498
5erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)6.21640437
6L-phenylalanine catabolic process (GO:0006559)6.21640437
7erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)5.58636452
8L-phenylalanine metabolic process (GO:0006558)5.58636452
9ensheathment of neurons (GO:0007272)5.36107103
10axon ensheathment (GO:0008366)5.36107103
11myelination (GO:0042552)5.31448507
12cholesterol biosynthetic process (GO:0006695)5.17553212
13mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.71167817
14long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)4.59028315
15aromatic amino acid family catabolic process (GO:0009074)4.58635860
16tyrosine metabolic process (GO:0006570)4.58462158
17sterol biosynthetic process (GO:0016126)4.56085154
18energy coupled proton transport, down electrochemical gradient (GO:0015985)4.43760427
19ATP synthesis coupled proton transport (GO:0015986)4.43760427
20myelin maintenance (GO:0043217)4.39401680
21very long-chain fatty acid metabolic process (GO:0000038)4.38756173
22fatty-acyl-CoA biosynthetic process (GO:0046949)4.36331002
23sequestering of actin monomers (GO:0042989)4.24754516
24response to methylmercury (GO:0051597)4.22155107
25long-chain fatty acid biosynthetic process (GO:0042759)4.21747736
26heme transport (GO:0015886)4.09758022
27establishment of protein localization to mitochondrial membrane (GO:0090151)4.04997157
28platelet dense granule organization (GO:0060155)4.01633302
29nephron tubule morphogenesis (GO:0072078)3.99076198
30nephron epithelium morphogenesis (GO:0072088)3.99076198
31bile acid biosynthetic process (GO:0006699)3.98642858
32long-chain fatty-acyl-CoA metabolic process (GO:0035336)3.96751633
33fatty-acyl-CoA metabolic process (GO:0035337)3.94830101
34regulation of lipoprotein metabolic process (GO:0050746)3.94520976
35amyloid precursor protein metabolic process (GO:0042982)3.81701046
36coenzyme catabolic process (GO:0009109)3.76725513
37creatine metabolic process (GO:0006600)3.74327243
38glyoxylate metabolic process (GO:0046487)3.72624542
39thioester biosynthetic process (GO:0035384)3.69574808
40acyl-CoA biosynthetic process (GO:0071616)3.69574808
41alpha-linolenic acid metabolic process (GO:0036109)3.67974425
42melanin biosynthetic process (GO:0042438)3.62893726
43positive regulation of gastrulation (GO:2000543)3.58921701
44kidney morphogenesis (GO:0060993)3.58028766
45aromatic amino acid family metabolic process (GO:0009072)3.57921840
46isoprenoid biosynthetic process (GO:0008299)3.57382062
47glycerophospholipid catabolic process (GO:0046475)3.49977280
48epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.47454196
49G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.45692707
50sulfation (GO:0051923)3.41715829
51iron coordination entity transport (GO:1901678)3.40894581
52mitochondrial respiratory chain complex I assembly (GO:0032981)3.39897426
53NADH dehydrogenase complex assembly (GO:0010257)3.39897426
54mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.39897426
55ketone body metabolic process (GO:1902224)3.37840025
56epithelial cilium movement (GO:0003351)3.35523191
57negative regulation of neurotransmitter secretion (GO:0046929)3.35163048
58negative regulation of protein localization to cell surface (GO:2000009)3.35128461
59bile acid metabolic process (GO:0008206)3.34473768
60protein complex biogenesis (GO:0070271)3.33376669
61neuronal action potential (GO:0019228)3.32617760
62triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.31413365
63short-chain fatty acid metabolic process (GO:0046459)3.30431270
64cofactor catabolic process (GO:0051187)3.29344754
65oligodendrocyte differentiation (GO:0048709)3.27631657
66secondary metabolite biosynthetic process (GO:0044550)3.26154068
67acyl-CoA metabolic process (GO:0006637)3.25701861
68thioester metabolic process (GO:0035383)3.25701861
69fucose catabolic process (GO:0019317)3.22242326
70L-fucose metabolic process (GO:0042354)3.22242326
71L-fucose catabolic process (GO:0042355)3.22242326
72neuron fate determination (GO:0048664)3.21139133
73postsynaptic membrane organization (GO:0001941)3.20869080
74negative regulation of neurotransmitter transport (GO:0051589)3.18365941
75cholesterol metabolic process (GO:0008203)3.17760840
76melanin metabolic process (GO:0006582)3.17635316
77response to pheromone (GO:0019236)3.17008776
78peptidyl-glutamic acid carboxylation (GO:0017187)3.15517987
79protein carboxylation (GO:0018214)3.15517987
80regulation of fibrinolysis (GO:0051917)3.14069754
81acetyl-CoA metabolic process (GO:0006084)3.13937518
82tryptophan catabolic process (GO:0006569)3.13734250
83indole-containing compound catabolic process (GO:0042436)3.13734250
84indolalkylamine catabolic process (GO:0046218)3.13734250
85cysteine metabolic process (GO:0006534)3.13680898
86establishment of mitochondrion localization (GO:0051654)3.13667155
87viral transcription (GO:0019083)3.13113674
88negative regulation of fibrinolysis (GO:0051918)3.12043918
89mitochondrial respiratory chain complex assembly (GO:0033108)3.11885691
90detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.11841562
91primitive streak formation (GO:0090009)3.11697770
92amyloid precursor protein catabolic process (GO:0042987)3.09936122
93plasma lipoprotein particle clearance (GO:0034381)3.09541262
94somite rostral/caudal axis specification (GO:0032525)3.08631453
95mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.06961167
96opsonization (GO:0008228)3.06830023
97translational termination (GO:0006415)3.05836069
98serotonin metabolic process (GO:0042428)3.03203130
99import into cell (GO:0098657)3.03051012
100negative regulation of telomere maintenance (GO:0032205)3.00452625
101primary amino compound metabolic process (GO:1901160)3.00114617
102positive regulation of cellular amine metabolic process (GO:0033240)2.99134492
103tryptophan metabolic process (GO:0006568)2.98840217
104high-density lipoprotein particle remodeling (GO:0034375)2.98762255
105regulation of protein activation cascade (GO:2000257)2.98631411
106electron transport chain (GO:0022900)2.98515880
107kynurenine metabolic process (GO:0070189)2.98434608
108renal tubule morphogenesis (GO:0061333)2.97496552
109synaptic transmission, cholinergic (GO:0007271)2.96603815
110steroid biosynthetic process (GO:0006694)2.95808198
111sterol metabolic process (GO:0016125)2.95544209
112cellular ketone body metabolic process (GO:0046950)2.94936258
113nonmotile primary cilium assembly (GO:0035058)2.94718590
114complement activation, alternative pathway (GO:0006957)2.94681653
115L-serine metabolic process (GO:0006563)2.93899656
116aldehyde catabolic process (GO:0046185)2.92841646
117respiratory electron transport chain (GO:0022904)2.92569034
118apical protein localization (GO:0045176)2.91535990
119regulation of collateral sprouting (GO:0048670)2.91411279
120response to lipoprotein particle (GO:0055094)2.90626064
121retinal cone cell development (GO:0046549)2.88954902
122positive regulation of triglyceride lipase activity (GO:0061365)2.88419811
123positive regulation of lipoprotein lipase activity (GO:0051006)2.88419811
124protein-cofactor linkage (GO:0018065)2.88053809
125presynaptic membrane assembly (GO:0097105)2.87765637
126regulation of triglyceride catabolic process (GO:0010896)2.87674937
127lymphangiogenesis (GO:0001946)2.87269471
128cholesterol efflux (GO:0033344)2.86619164
129regulation of cholesterol esterification (GO:0010872)2.84698120
130asymmetric protein localization (GO:0008105)2.84486257
131water-soluble vitamin biosynthetic process (GO:0042364)2.83459387
132nucleotide transmembrane transport (GO:1901679)2.82928435
133regulation of cholesterol metabolic process (GO:0090181)2.81455434
134somite development (GO:0061053)2.80303359
135hydrogen ion transmembrane transport (GO:1902600)2.79157959
136aspartate family amino acid catabolic process (GO:0009068)2.78350532
137dopaminergic neuron differentiation (GO:0071542)2.77467780
138dicarboxylic acid catabolic process (GO:0043649)2.77113907
139glutathione derivative biosynthetic process (GO:1901687)2.77072575
140glutathione derivative metabolic process (GO:1901685)2.77072575
141regulation of complement activation (GO:0030449)2.76015924
142positive regulation of oligodendrocyte differentiation (GO:0048714)2.75725495
143sulfur amino acid catabolic process (GO:0000098)2.75182431
144glutamate metabolic process (GO:0006536)2.75180031
145proton transport (GO:0015992)2.74386470
146astrocyte development (GO:0014002)2.73937024
147eye photoreceptor cell differentiation (GO:0001754)2.73746335
148photoreceptor cell differentiation (GO:0046530)2.73746335
149behavioral response to ethanol (GO:0048149)2.73682035
150ethanol oxidation (GO:0006069)2.73099623
151regulation of cholesterol biosynthetic process (GO:0045540)2.72913435
152detection of light stimulus involved in visual perception (GO:0050908)2.72373387
153detection of light stimulus involved in sensory perception (GO:0050962)2.72373387
154peristalsis (GO:0030432)2.71194119
155hydrogen transport (GO:0006818)2.67887696
156auditory behavior (GO:0031223)2.67171630
157spinal cord motor neuron differentiation (GO:0021522)2.66418943
158cilium movement (GO:0003341)2.64801003
159cotranslational protein targeting to membrane (GO:0006613)2.63788143
160mannosylation (GO:0097502)2.62978256
161SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.59399618
162regulation of mesoderm development (GO:2000380)2.59057571
163protein targeting to ER (GO:0045047)2.58125292
164cell differentiation in spinal cord (GO:0021515)2.58114133
165axonemal dynein complex assembly (GO:0070286)2.58020722
166centriole replication (GO:0007099)2.57881344
167N-acetylglucosamine metabolic process (GO:0006044)2.57790564
168inner ear receptor stereocilium organization (GO:0060122)2.57211958
169gamma-aminobutyric acid transport (GO:0015812)2.56133524
170pyrimidine nucleobase catabolic process (GO:0006208)2.55439514
171multicellular organism reproduction (GO:0032504)2.55138353
172ATP biosynthetic process (GO:0006754)2.54306895
173intracellular protein transmembrane import (GO:0044743)2.51901687
174glomerulus development (GO:0032835)2.50782957
175protein neddylation (GO:0045116)2.50254627
176piRNA metabolic process (GO:0034587)2.47886216
177negative regulation of axon guidance (GO:1902668)2.47880163
178smoothened signaling pathway (GO:0007224)2.46928181
179cellular response to ATP (GO:0071318)2.46380393
180neuron cell-cell adhesion (GO:0007158)2.44757351
181establishment of protein localization to endoplasmic reticulum (GO:0072599)2.44138682
182nucleobase catabolic process (GO:0046113)2.43442660
183regulation of posttranscriptional gene silencing (GO:0060147)2.43099364
184regulation of gene silencing by miRNA (GO:0060964)2.43099364
185regulation of gene silencing by RNA (GO:0060966)2.43099364
186purine ribonucleoside bisphosphate metabolic process (GO:0034035)2.42985493
1873-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.42985493
188phasic smooth muscle contraction (GO:0014821)2.42900375
189translational elongation (GO:0006414)2.42403854
190cilium morphogenesis (GO:0060271)2.41979972
191presynaptic membrane organization (GO:0097090)2.40752082
192regulation of hippo signaling (GO:0035330)2.40139883
193regulation of action potential (GO:0098900)2.39509454
194reflex (GO:0060004)2.39039340
195respiratory chain complex IV assembly (GO:0008535)2.38449087
196cochlea development (GO:0090102)2.37775357
197neuronal stem cell maintenance (GO:0097150)2.37490002
198DNA deamination (GO:0045006)2.36430655

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse5.28860097
2EZH2_22144423_ChIP-Seq_EOC_Human4.61705151
3RXR_22158963_ChIP-Seq_LIVER_Mouse3.70802697
4ZNF274_21170338_ChIP-Seq_K562_Hela3.41516133
5EGR1_23403033_ChIP-Seq_LIVER_Mouse3.41319598
6* LXR_22158963_ChIP-Seq_LIVER_Mouse3.21672705
7PPARA_22158963_ChIP-Seq_LIVER_Mouse2.79156402
8FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.52399174
9* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse2.34054217
10BMI1_23680149_ChIP-Seq_NPCS_Mouse2.31872850
11GBX2_23144817_ChIP-Seq_PC3_Human2.28072406
12SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.12524760
13CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.02525036
14FUS_26573619_Chip-Seq_HEK293_Human1.99001744
15TAF15_26573619_Chip-Seq_HEK293_Human1.97134726
16EWS_26573619_Chip-Seq_HEK293_Human1.94980274
17NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.90250208
18NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.88472114
19HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.84537823
20PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.81584920
21MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.77892694
22FLI1_27457419_Chip-Seq_LIVER_Mouse1.77482850
23OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.69237239
24HTT_18923047_ChIP-ChIP_STHdh_Human1.68818929
25HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.68227809
26TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.65604625
27POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.65604625
28CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.65447235
29AR_21572438_ChIP-Seq_LNCaP_Human1.63044407
30MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.56848786
31EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.56375496
32RNF2_27304074_Chip-Seq_NSC_Mouse1.56013179
33SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.53918770
34REST_21632747_ChIP-Seq_MESCs_Mouse1.53160790
35PCGF2_27294783_Chip-Seq_ESCs_Mouse1.51504843
36NRF2_20460467_ChIP-Seq_MEFs_Mouse1.50015822
37NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.50015822
38PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.49305963
39TP63_19390658_ChIP-ChIP_HaCaT_Human1.48855358
40BCAT_22108803_ChIP-Seq_LS180_Human1.48737871
41SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.45811375
42VDR_22108803_ChIP-Seq_LS180_Human1.45710158
43E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.45705086
44ZFP57_27257070_Chip-Seq_ESCs_Mouse1.43469428
45CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.43007899
46* MYC_18940864_ChIP-ChIP_HL60_Human1.41445250
47MTF2_20144788_ChIP-Seq_MESCs_Mouse1.40338536
48CDX2_19796622_ChIP-Seq_MESCs_Mouse1.39593831
49* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.38674225
50FOXA1_25329375_ChIP-Seq_VCAP_Human1.36841600
51FOXA1_27270436_Chip-Seq_PROSTATE_Human1.36841600
52VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.35332872
53GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.35303666
54* ER_23166858_ChIP-Seq_MCF-7_Human1.34345858
55SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.34199752
56FOXA2_19822575_ChIP-Seq_HepG2_Human1.33165238
57GABP_17652178_ChIP-ChIP_JURKAT_Human1.32715195
58TRIM28_21343339_ChIP-Seq_HEK293_Human1.32496947
59PCGF2_27294783_Chip-Seq_NPCs_Mouse1.31039079
60* AR_25329375_ChIP-Seq_VCAP_Human1.30106817
61FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.28496686
62RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.26948868
63JARID2_20064375_ChIP-Seq_MESCs_Mouse1.25659385
64EST1_17652178_ChIP-ChIP_JURKAT_Human1.25497812
65* PIAS1_25552417_ChIP-Seq_VCAP_Human1.25132696
66EED_16625203_ChIP-ChIP_MESCs_Mouse1.24541516
67TP53_22573176_ChIP-Seq_HFKS_Human1.24436618
68SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.22731772
69RNF2_18974828_ChIP-Seq_MESCs_Mouse1.22638215
70EZH2_18974828_ChIP-Seq_MESCs_Mouse1.22638215
71STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.22385669
72SMAD4_21799915_ChIP-Seq_A2780_Human1.21683474
73SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.21329043
74ETV2_25802403_ChIP-Seq_MESCs_Mouse1.21213875
75TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.19794273
76BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.18850257
77NOTCH1_21737748_ChIP-Seq_TLL_Human1.17546816
78EZH2_27294783_Chip-Seq_ESCs_Mouse1.17229023
79ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.17006429
80GATA3_21878914_ChIP-Seq_MCF-7_Human1.16691216
81IGF1R_20145208_ChIP-Seq_DFB_Human1.15944641
82RBPJ_22232070_ChIP-Seq_NCS_Mouse1.15817117
83EZH2_27304074_Chip-Seq_ESCs_Mouse1.15257869
84SUZ12_27294783_Chip-Seq_ESCs_Mouse1.14467284
85SALL1_21062744_ChIP-ChIP_HESCs_Human1.14286321
86* TCF4_23295773_ChIP-Seq_U87_Human1.13552954
87POU3F2_20337985_ChIP-ChIP_501MEL_Human1.13379086
88* SMAD3_21741376_ChIP-Seq_EPCs_Human1.12621445
89WT1_19549856_ChIP-ChIP_CCG9911_Human1.12313551
90ESR2_21235772_ChIP-Seq_MCF-7_Human1.12308272
91SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.11741653
92RUNX2_22187159_ChIP-Seq_PCA_Human1.10848051
93CBP_20019798_ChIP-Seq_JUKART_Human1.09737844
94IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.09737844
95EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.08251627
96POU5F1_16153702_ChIP-ChIP_HESCs_Human1.08002294
97CTBP1_25329375_ChIP-Seq_LNCAP_Human1.07961747
98RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.07815884
99ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.07569609
100* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.05426677
101TCF4_22108803_ChIP-Seq_LS180_Human1.05202655
102FOXA1_21572438_ChIP-Seq_LNCaP_Human1.05075474
103* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.04889994
104PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.04728132
105SUZ12_27294783_Chip-Seq_NPCs_Mouse1.04639240
106AR_20517297_ChIP-Seq_VCAP_Human1.03787686
107TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03713256
108PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.02814078
109NFE2_27457419_Chip-Seq_LIVER_Mouse1.01843469
110TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.01203483
111TP53_16413492_ChIP-PET_HCT116_Human1.00837418
112JARID2_20075857_ChIP-Seq_MESCs_Mouse1.00577340
113CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.99185723
114* P300_19829295_ChIP-Seq_ESCs_Human0.98277612
115CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97144037
116FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.96670782
117EP300_21415370_ChIP-Seq_HL-1_Mouse0.96550456
118NANOG_20526341_ChIP-Seq_ESCs_Human0.96519234
119SOX2_27498859_Chip-Seq_STOMACH_Mouse0.95571239
120EOMES_21245162_ChIP-Seq_HESCs_Human0.94981724
121TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.94173469
122DROSHA_22980978_ChIP-Seq_HELA_Human0.93868806
123* SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.93313157
124RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.92811559
125NR3C1_21868756_ChIP-Seq_MCF10A_Human0.92397077
126UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.89318360
127IRF1_19129219_ChIP-ChIP_H3396_Human0.89136312
128PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.89038624
129CTBP2_25329375_ChIP-Seq_LNCAP_Human0.88181276
130GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.88101972
131PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.87851610
132* TAL1_26923725_Chip-Seq_HPCs_Mouse0.87364663
133CBX2_27304074_Chip-Seq_ESCs_Mouse0.87116178
134* PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.86948338
135* STAT3_23295773_ChIP-Seq_U87_Human0.86852338
136CBP_21632823_ChIP-Seq_H3396_Human0.86834266
137AUTS2_25519132_ChIP-Seq_293T-REX_Human0.86805161
138ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.86751666
139RNF2_27304074_Chip-Seq_ESCs_Mouse0.86323658
140BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.86094845
141AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.85841141
142NANOG_19829295_ChIP-Seq_ESCs_Human0.85029367
143SOX2_19829295_ChIP-Seq_ESCs_Human0.85029367
144GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.82784266
145MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.81199867
146FOXO3_23340844_ChIP-Seq_DLD1_Human0.81130585
147ZNF217_24962896_ChIP-Seq_MCF-7_Human0.80816606
148FOXA1_25552417_ChIP-Seq_VCAP_Human0.78892750
149PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.78687437
150SMAD4_21741376_ChIP-Seq_EPCs_Human0.78286946
151CMYC_18555785_Chip-Seq_ESCs_Mouse0.78226900
152SOX9_26525672_Chip-Seq_Limbbuds_Mouse0.77440857
153LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.74980482

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system4.78097790
2MP0000920_abnormal_myelination4.45524150
3MP0005360_urolithiasis4.06922843
4MP0003806_abnormal_nucleotide_metabolis3.96915229
5MP0005171_absent_coat_pigmentation3.63242995
6MP0005085_abnormal_gallbladder_physiolo3.47839547
7MP0003136_yellow_coat_color3.30925479
8MP0010030_abnormal_orbit_morphology3.16608817
9MP0003690_abnormal_glial_cell3.00926837
10MP0005365_abnormal_bile_salt2.95634199
11MP0006292_abnormal_olfactory_placode2.86391685
12MP0008875_abnormal_xenobiotic_pharmacok2.79169190
13MP0003950_abnormal_plasma_membrane2.75617826
14MP0000372_irregular_coat_pigmentation2.67141373
15MP0004381_abnormal_hair_follicle2.66439114
16MP0003195_calcinosis2.64888751
17MP0005408_hypopigmentation2.56521391
18MP0009840_abnormal_foam_cell2.50620772
19MP0009379_abnormal_foot_pigmentation2.49811343
20MP0003329_amyloid_beta_deposits2.35749950
21MP0004885_abnormal_endolymph2.19236264
22MP0004133_heterotaxia2.11484447
23MP0000569_abnormal_digit_pigmentation2.11478757
24MP0002102_abnormal_ear_morphology2.08558588
25MP0001968_abnormal_touch/_nociception1.99678823
26MP0003283_abnormal_digestive_organ1.99056886
27MP0002736_abnormal_nociception_after1.94365589
28MP0005083_abnormal_biliary_tract1.93789679
29MP0003890_abnormal_embryonic-extraembry1.90097863
30MP0004270_analgesia1.88502251
31MP0003252_abnormal_bile_duct1.88498124
32MP0005084_abnormal_gallbladder_morpholo1.84045798
33MP0005332_abnormal_amino_acid1.77952730
34MP0005451_abnormal_body_composition1.73927741
35MP0003634_abnormal_glial_cell1.69446462
36MP0004142_abnormal_muscle_tone1.65623960
37MP0002735_abnormal_chemical_nociception1.64036619
38MP0001529_abnormal_vocalization1.63924264
39MP0000604_amyloidosis1.63795797
40MP0003718_maternal_effect1.63594369
41MP0005409_darkened_coat_color1.63417727
42MP0002928_abnormal_bile_duct1.62129195
43MP0010329_abnormal_lipoprotein_level1.61726018
44MP0004742_abnormal_vestibular_system1.60392708
45MP0003880_abnormal_central_pattern1.59863812
46MP0003632_abnormal_nervous_system1.58641003
47MP0002118_abnormal_lipid_homeostasis1.57258115
48MP0006072_abnormal_retinal_apoptosis1.56404377
49MP0001485_abnormal_pinna_reflex1.50096009
50MP0002638_abnormal_pupillary_reflex1.47405876
51MP0002277_abnormal_respiratory_mucosa1.47118415
52MP0010678_abnormal_skin_adnexa1.40477926
53MP0001986_abnormal_taste_sensitivity1.40074612
54MP0001666_abnormal_nutrient_absorption1.39150182
55MP0008438_abnormal_cutaneous_collagen1.38972152
56MP0002272_abnormal_nervous_system1.37180490
57MP0001905_abnormal_dopamine_level1.36875699
58MP0002229_neurodegeneration1.36585812
59MP0002572_abnormal_emotion/affect_behav1.35824250
60MP0005253_abnormal_eye_physiology1.33018091
61MP0001486_abnormal_startle_reflex1.32680075
62MP0008877_abnormal_DNA_methylation1.32254205
63MP0000631_abnormal_neuroendocrine_gland1.30824760
64MP0005174_abnormal_tail_pigmentation1.28451361
65MP0002733_abnormal_thermal_nociception1.27156035
66MP0002282_abnormal_trachea_morphology1.26665362
67MP0001970_abnormal_pain_threshold1.26617436
68MP0006276_abnormal_autonomic_nervous1.25143921
69MP0003011_delayed_dark_adaptation1.23749961
70MP0002067_abnormal_sensory_capabilities1.23163046
71MP0002557_abnormal_social/conspecific_i1.19192543
72MP0010386_abnormal_urinary_bladder1.18069850
73MP0003656_abnormal_erythrocyte_physiolo1.17884960
74MP0001293_anophthalmia1.17576721
75MP0000462_abnormal_digestive_system1.16664651
76MP0003191_abnormal_cellular_cholesterol1.16542888
77MP0000049_abnormal_middle_ear1.15896643
78MP0002876_abnormal_thyroid_physiology1.15816669
79MP0005410_abnormal_fertilization1.15270187
80MP0002751_abnormal_autonomic_nervous1.15234940
81MP0003631_nervous_system_phenotype1.14758780
82MP0008872_abnormal_physiological_respon1.14676232
83MP0002653_abnormal_ependyma_morphology1.13269737
84MP0003119_abnormal_digestive_system1.13242558
85MP0000566_synostosis1.12440434
86MP0002063_abnormal_learning/memory/cond1.10600567
87MP0000026_abnormal_inner_ear1.10478978
88MP0000778_abnormal_nervous_system1.09220096
89MP0005584_abnormal_enzyme/coenzyme_acti1.09011897
90MP0002160_abnormal_reproductive_system1.08348274
91MP0004043_abnormal_pH_regulation1.07961202
92MP0005058_abnormal_lysosome_morphology1.07860813
93MP0001661_extended_life_span1.06928728
94MP0002837_dystrophic_cardiac_calcinosis1.06478604
95MP0000383_abnormal_hair_follicle1.05539508
96MP0008260_abnormal_autophagy1.05274164
97MP0003938_abnormal_ear_development1.04387974
98MP0000427_abnormal_hair_cycle1.02426930
99MP0001501_abnormal_sleep_pattern1.01850389
100MP0005551_abnormal_eye_electrophysiolog1.00336367
101MP0002064_seizures1.00238295
102MP0000230_abnormal_systemic_arterial1.00228881
103MP0001502_abnormal_circadian_rhythm0.98280375
104MP0004147_increased_porphyrin_level0.97974626
105MP0003635_abnormal_synaptic_transmissio0.97329813
106MP0003633_abnormal_nervous_system0.95495619
107MP0005389_reproductive_system_phenotype0.93398424
108MP0000647_abnormal_sebaceous_gland0.92177347
109MP0004134_abnormal_chest_morphology0.91161465
110MP0001984_abnormal_olfaction0.90545145
111MP0001346_abnormal_lacrimal_gland0.90315650
112MP0005075_abnormal_melanosome_morpholog0.89743642
113MP0000747_muscle_weakness0.88868020
114MP0002295_abnormal_pulmonary_circulatio0.87884066
115MP0005391_vision/eye_phenotype0.86853378
116MP0001286_abnormal_eye_development0.85416168
117MP0005187_abnormal_penis_morphology0.85361156
118MP0000538_abnormal_urinary_bladder0.84579260
119MP0003868_abnormal_feces_composition0.84287997
120MP0000579_abnormal_nail_morphology0.83730404
121MP0000609_abnormal_liver_physiology0.82497721
122MP0009250_abnormal_appendicular_skeleto0.82035196
123MP0000955_abnormal_spinal_cord0.80802471
124MP0005645_abnormal_hypothalamus_physiol0.80304835
125MP0008789_abnormal_olfactory_epithelium0.79609117
126MP0002095_abnormal_skin_pigmentation0.78363228
127MP0005595_abnormal_vascular_smooth0.78086683
128MP0001299_abnormal_eye_distance/0.77529089
129MP0005646_abnormal_pituitary_gland0.77040915
130MP0003937_abnormal_limbs/digits/tail_de0.76931735
131MP0001664_abnormal_digestion0.74502798
132MP0002909_abnormal_adrenal_gland0.73567953
133MP0005423_abnormal_somatic_nervous0.73523373
134MP0000762_abnormal_tongue_morphology0.72524775
135MP0001324_abnormal_eye_pigmentation0.70298569
136MP0001963_abnormal_hearing_physiology0.70193517
137MP0009384_cardiac_valve_regurgitation0.69510833
138MP0002938_white_spotting0.69222701
139MP0004185_abnormal_adipocyte_glucose0.69212694
140MP0002822_catalepsy0.68551328
141MP0002090_abnormal_vision0.67451273
142MP0000639_abnormal_adrenal_gland0.65986706
143MP0000467_abnormal_esophagus_morphology0.65936654
144MP0005195_abnormal_posterior_eye0.64946931
145MP0004019_abnormal_vitamin_homeostasis0.64630432
146MP0009697_abnormal_copulation0.64249254
147MP0002066_abnormal_motor_capabilities/c0.63920921
148MP0003186_abnormal_redox_activity0.62919728
149MP0001177_atelectasis0.62737213
150MP0002734_abnormal_mechanical_nocicepti0.62154528
151MP0004272_abnormal_basement_membrane0.61589960
152MP0009765_abnormal_xenobiotic_induced0.59384338
153MP0002882_abnormal_neuron_morphology0.59333664
154MP0004924_abnormal_behavior0.57728432
155MP0005386_behavior/neurological_phenoty0.57728432
156MP0006082_CNS_inflammation0.57510987
157MP0001340_abnormal_eyelid_morphology0.56431384
158MP0001851_eye_inflammation0.56125637
159MP0002752_abnormal_somatic_nervous0.56108358
160MP0009046_muscle_twitch0.54049212
161MP0009745_abnormal_behavioral_response0.53796978
162MP0001542_abnormal_bone_strength0.52408677

Predicted human phenotypes

RankGene SetZ-score
1Neurofibrillary tangles (HP:0002185)5.38246995
2Degeneration of the lateral corticospinal tracts (HP:0002314)5.30491230
3Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)5.30491230
4Intrahepatic cholestasis (HP:0001406)5.25883387
5Abnormality of aromatic amino acid family metabolism (HP:0004338)5.22989359
6Deep venous thrombosis (HP:0002625)4.44153240
7Hyperlipoproteinemia (HP:0010980)4.11995058
8Abnormality of the corticospinal tract (HP:0002492)4.10486346
9Molar tooth sign on MRI (HP:0002419)4.09461477
10Abnormality of midbrain morphology (HP:0002418)4.09461477
11Parakeratosis (HP:0001036)4.08210603
12Xanthomatosis (HP:0000991)4.03131461
13Type II lissencephaly (HP:0007260)4.02273470
14Cerebral inclusion bodies (HP:0100314)3.95901147
15Pancreatic cysts (HP:0001737)3.84424551
16Congenital, generalized hypertrichosis (HP:0004540)3.84347284
17Prolonged partial thromboplastin time (HP:0003645)3.64752910
18Peripheral hypomyelination (HP:0007182)3.61511321
19Pancreatic fibrosis (HP:0100732)3.58764804
20Onion bulb formation (HP:0003383)3.55990657
21Sensory axonal neuropathy (HP:0003390)3.46866082
22Nephronophthisis (HP:0000090)3.39918953
23Insidious onset (HP:0003587)3.38891511
24Termporal pattern (HP:0011008)3.38891511
25True hermaphroditism (HP:0010459)3.33093485
26Birth length less than 3rd percentile (HP:0003561)3.29020346
27Congenital stationary night blindness (HP:0007642)3.24615401
28Abnormality of monocarboxylic acid metabolism (HP:0010996)3.16480329
29Large for gestational age (HP:0001520)3.11128725
30Abnormality of methionine metabolism (HP:0010901)3.06091104
31Abnormal auditory evoked potentials (HP:0006958)3.05247863
32Spastic paraparesis (HP:0002313)3.02525408
33Hypobetalipoproteinemia (HP:0003563)2.97096868
34Anterior segment dysgenesis (HP:0007700)2.96758764
35Abnormality of the renal medulla (HP:0100957)2.92561164
36Concave nail (HP:0001598)2.92438861
37Spastic gait (HP:0002064)2.90252532
38Hypophosphatemic rickets (HP:0004912)2.88362991
39Segmental peripheral demyelination/remyelination (HP:0003481)2.86693641
40Congenital sensorineural hearing impairment (HP:0008527)2.84694169
41Complement deficiency (HP:0004431)2.80859470
42Abnormality of aspartate family amino acid metabolism (HP:0010899)2.76629596
43Blue irides (HP:0000635)2.76240711
44Fat malabsorption (HP:0002630)2.70730621
45Abnormal number of erythroid precursors (HP:0012131)2.69764048
46Abnormality of the renal cortex (HP:0011035)2.69636870
47Hyperventilation (HP:0002883)2.67977249
48Epidermoid cyst (HP:0200040)2.67915654
49Tubular atrophy (HP:0000092)2.67700686
50Abnormality of the pons (HP:0007361)2.64654440
51Increased serum pyruvate (HP:0003542)2.63529538
52Abnormality of glycolysis (HP:0004366)2.63529538
53Intention tremor (HP:0002080)2.63467036
54Abnormality of alanine metabolism (HP:0010916)2.62541824
55Hyperalaninemia (HP:0003348)2.62541824
56Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.62541824
57Pendular nystagmus (HP:0012043)2.61725072
58Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.61651533
59Medial flaring of the eyebrow (HP:0010747)2.60712378
60Cerebral hypomyelination (HP:0006808)2.59582082
61Optic nerve hypoplasia (HP:0000609)2.59319239
62Inability to walk (HP:0002540)2.57999981
63Prominent supraorbital ridges (HP:0000336)2.55627912
64Supranuclear gaze palsy (HP:0000605)2.54230924
65Leukodystrophy (HP:0002415)2.52379355
66Polydipsia (HP:0001959)2.50445980
67Abnormal drinking behavior (HP:0030082)2.50445980
68Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.48524004
69Paraparesis (HP:0002385)2.48287083
70Alacrima (HP:0000522)2.46752918
71Septo-optic dysplasia (HP:0100842)2.45869518
72Cerebral hemorrhage (HP:0001342)2.44072911
73Abnormality of serine family amino acid metabolism (HP:0010894)2.42604682
74Abnormality of glycine metabolism (HP:0010895)2.42604682
75Abnormality of cells of the erythroid lineage (HP:0012130)2.42468185
76Conjugated hyperbilirubinemia (HP:0002908)2.42155065
77Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.42030849
78Scanning speech (HP:0002168)2.41038208
79Patellar aplasia (HP:0006443)2.40633844
80Hypoplasia of the pons (HP:0012110)2.39560622
81Autoamputation (HP:0001218)2.39134692
82Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.38635949
83Cerebellar dysplasia (HP:0007033)2.37387473
84Increased corneal curvature (HP:0100692)2.36143276
85Keratoconus (HP:0000563)2.36143276
86White forelock (HP:0002211)2.35193795
87Cholecystitis (HP:0001082)2.34248602
88Abnormal gallbladder physiology (HP:0012438)2.34248602
89Attenuation of retinal blood vessels (HP:0007843)2.34042657
90Cystic liver disease (HP:0006706)2.33949801
91Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.33378856
92Bilateral microphthalmos (HP:0007633)2.33315545
93Abnormal respiratory epithelium morphology (HP:0012253)2.33170225
94Abnormal respiratory motile cilium morphology (HP:0005938)2.33170225
95Steatorrhea (HP:0002570)2.32485285
96Lissencephaly (HP:0001339)2.32210565
97Axonal loss (HP:0003447)2.31391524
98Amyloidosis (HP:0011034)2.31283057
99Progressive cerebellar ataxia (HP:0002073)2.30857767
100Peripheral demyelination (HP:0011096)2.30375325
101Joint hemorrhage (HP:0005261)2.29588432
102Dysmetria (HP:0001310)2.27786444
103Aplasia/Hypoplasia of the patella (HP:0006498)2.26022180
104Premature skin wrinkling (HP:0100678)2.25509356
105Sclerocornea (HP:0000647)2.25485701
106Congenital ichthyosiform erythroderma (HP:0007431)2.25361334
107Hyperammonemia (HP:0001987)2.25247410
108Abnormal respiratory motile cilium physiology (HP:0012261)2.25108086
109Abnormality of sulfur amino acid metabolism (HP:0004339)2.24645134
110Patchy hypopigmentation of hair (HP:0011365)2.24368824
111Slow saccadic eye movements (HP:0000514)2.23932226
112Microretrognathia (HP:0000308)2.21814392
113Stridor (HP:0010307)2.21488007
114Abnormality of the common coagulation pathway (HP:0010990)2.21395945
115Decreased circulating renin level (HP:0003351)2.20634835
116Mitochondrial inheritance (HP:0001427)2.20156744
117Anencephaly (HP:0002323)2.18899186
118Reticulocytopenia (HP:0001896)2.18081812
119Hyperglycinemia (HP:0002154)2.17715859
120Ketosis (HP:0001946)2.17622449
121Hypoplastic pelvis (HP:0008839)2.17528147
122Acute necrotizing encephalopathy (HP:0006965)2.17478096
123Hypoplasia of the iris (HP:0007676)2.16701507
124Hypolipoproteinemia (HP:0010981)2.16148561
125Polyuria (HP:0000103)2.15730456
126Coronal craniosynostosis (HP:0004440)2.14856125
127Abnormal ciliary motility (HP:0012262)2.12145291
128Prolonged neonatal jaundice (HP:0006579)2.12089602
129Rickets (HP:0002748)2.11877588
130Gait imbalance (HP:0002141)2.10934870
131Optic disc pallor (HP:0000543)2.09460831
132Infantile muscular hypotonia (HP:0008947)2.08839655
133Aplasia/Hypoplasia of the tongue (HP:0010295)2.08426466
134Spastic tetraparesis (HP:0001285)2.08375339
135Decreased central vision (HP:0007663)2.07064894
136Anophthalmia (HP:0000528)2.06837011
137Breast hypoplasia (HP:0003187)2.06812030
138Dynein arm defect of respiratory motile cilia (HP:0012255)2.06245059
139Absent/shortened dynein arms (HP:0200106)2.06245059
140Oligodactyly (hands) (HP:0001180)2.06202505
141Furrowed tongue (HP:0000221)2.05611524
142Chronic hepatic failure (HP:0100626)2.04486350
143Hypothermia (HP:0002045)2.03631736
144Abnormal pancreas size (HP:0012094)2.03326841
145Anteriorly placed anus (HP:0001545)2.02420540
146Abnormal rod and cone electroretinograms (HP:0008323)2.01554560
147Aplasia/Hypoplasia of the fovea (HP:0008060)2.00798918
148Hypoplasia of the fovea (HP:0007750)2.00798918
149Methylmalonic acidemia (HP:0002912)1.99062771
150Hammertoe (HP:0001765)1.97855863
151Congenital primary aphakia (HP:0007707)1.96615929
152Cerebral edema (HP:0002181)1.96600731
153Retinal dysplasia (HP:0007973)1.94173565
154Pheochromocytoma (HP:0002666)1.94086062
155Rhinitis (HP:0012384)1.93454182
156Decreased lacrimation (HP:0000633)1.93358801
157Ankle clonus (HP:0011448)1.91364688
158Turricephaly (HP:0000262)1.89583551
159Ulnar claw (HP:0001178)1.89325346
160Vascular calcification (HP:0004934)1.88864936
161Hypoalphalipoproteinemia (HP:0003233)1.88851001
162Confusion (HP:0001289)1.88816144
163Foot dorsiflexor weakness (HP:0009027)1.88808791
164Congenital hepatic fibrosis (HP:0002612)1.88557203
165Abnormal gallbladder morphology (HP:0012437)1.88426051
166Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.88150956
167Acute encephalopathy (HP:0006846)1.87674361
168Decreased motor nerve conduction velocity (HP:0003431)1.87539707
169Morphological abnormality of the pyramidal tract (HP:0002062)1.87229309
170Abolished electroretinogram (ERG) (HP:0000550)1.87212649
171Limb dystonia (HP:0002451)1.84477739
172Hepatosplenomegaly (HP:0001433)1.83820627
173Abnormal mitochondria in muscle tissue (HP:0008316)1.83472763
174Progressive macrocephaly (HP:0004481)1.82108737
175Rib fusion (HP:0000902)1.80457773
176Bile duct proliferation (HP:0001408)1.79978987
177Abnormal biliary tract physiology (HP:0012439)1.79978987
178Pachygyria (HP:0001302)1.79741448
179Increased hepatocellular lipid droplets (HP:0006565)1.79688464
180Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.79433312
181Genital tract atresia (HP:0001827)1.78432880
182Thickened helices (HP:0000391)1.77921754
183Increased CSF lactate (HP:0002490)1.77555831
184Absent rod-and cone-mediated responses on ERG (HP:0007688)1.76409467
185Hemiparesis (HP:0001269)1.75845978
186Fair hair (HP:0002286)1.75491224
187Broad-based gait (HP:0002136)1.75107914
188Hepatocellular necrosis (HP:0001404)1.75016200
189Clumsiness (HP:0002312)1.73940454
190Vaginal atresia (HP:0000148)1.73711471
191Aplasia/Hypoplasia affecting the retina (HP:0008061)1.73627586
192Distal sensory impairment (HP:0002936)1.73509199
193Abnormal urine output (HP:0012590)1.73291063
194Abnormality of glutamine family amino acid metabolism (HP:0010902)1.72966823
195Abnormality of fatty-acid metabolism (HP:0004359)1.72568834
196Abnormality of complement system (HP:0005339)1.72350070
197Spastic paraplegia (HP:0001258)1.72268879
198Macrocytic anemia (HP:0001972)1.71816447

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK396.24171218
2OXSR14.29590451
3EPHB13.96035900
4MET3.55997637
5FGFR22.99977465
6PBK2.94791888
7PKN12.74873578
8ZAK2.74816033
9WNK42.58843798
10BCR2.57725563
11FRK2.50369854
12ACVR1B2.42836819
13TSSK62.40490458
14MST1R2.37478566
15GRK12.32284846
16TLK12.27696021
17MAPKAPK52.26250434
18WNK32.25113348
19EPHB22.12913319
20CDK192.04365275
21ICK1.76929253
22TGFBR11.75709820
23CSNK1G31.71610015
24LIMK11.67346566
25BCKDK1.66948258
26NEK21.66852785
27MAPK131.63104664
28WNK11.62359179
29CSNK1A1L1.62039329
30NTRK11.57987580
31CAMKK21.54087495
32NEK61.52327701
33ADRBK11.52277261
34CAMK2B1.52085273
35TESK21.50658832
36UHMK11.45451552
37CSNK1G11.45194309
38NTRK21.40217156
39TAOK31.39176934
40NME11.28854807
41ERBB41.28162959
42ROCK21.27064505
43SGK2231.26902238
44SGK4941.26902238
45CAMK2D1.25924252
46CSNK1G21.24809034
47PRPF4B1.24329467
48VRK11.22959151
49PRKCG1.21394568
50FGR1.20768453
51CAMK2G1.19716686
52NUAK11.17774119
53MAP3K41.16496724
54MAP3K91.15303440
55MKNK21.14221049
56PNCK1.13963346
57CLK11.13862427
58WEE11.13439435
59TNIK1.10712055
60NTRK31.07903844
61PAK61.04980548
62MAPK151.03124774
63PAK31.02690760
64BMX1.01756850
65VRK21.00752161
66CASK1.00483550
67BRSK20.98790782
68PRKCQ0.94325324
69DYRK30.92844217
70PRKD10.83591028
71CAMKK10.80811653
72MARK20.80706707
73GSK3A0.80705402
74DYRK20.80537044
75EPHA30.80083902
76MAP4K20.75152221
77PASK0.73091169
78CAMK2A0.73066716
79IRAK20.72638290
80DDR20.71164143
81FGFR40.70928664
82PTK2B0.69708421
83PRKCE0.68530973
84SIK10.68081440
85PLK30.67335219
86BMPR1B0.67184711
87MKNK10.63555007
88PRKCI0.63077438
89PLK40.62545809
90PDPK10.61500596
91PIK3CA0.61386102
92EPHA40.61360012
93MAPKAPK30.60606593
94MAP2K70.58759132
95IRAK40.58449568
96CDK50.57214171
97CDK140.56297285
98TYRO30.54579414
99MAP2K20.54262296
100MAPK70.54124464
101NLK0.53748829
102CAMK10.53363450
103STK38L0.52966737
104MAP3K130.52367713
105MST40.52231571
106CSNK1D0.51057589
107CAMK1G0.50451540
108GRK70.50291039
109FYN0.49759135
110PHKG20.48802427
111PHKG10.48802427
112ABL20.48594681
113CDK150.48486598
114RPS6KA50.48443545
115MAP2K10.47332233
116IRAK10.46232680
117PRKACB0.45970233
118CAMK1D0.44362009
119CDK30.43992719
120TRPM70.43798505
121PRKG10.43398965
122KSR20.43107459
123CDK180.42667081
124CHUK0.40502947
125CDK11A0.40476800
126PINK10.39072120
127MARK10.37887169
128CDC70.37863478
129CSNK1A10.37586682
130PRKCH0.35880648
131INSRR0.35576076
132STK110.35060395
133PIK3CG0.34858858
134PRKCA0.32414234
135INSR0.32165582
136PRKCZ0.31959518
137TIE10.31953246
138ARAF0.31451246
139STK240.31395326
140MAPK120.29274224
141MAP2K60.28415025
142RPS6KA60.27766159
143ERBB20.27557859
144MUSK0.27272133
145CDK80.26815027
146DAPK20.26248949
147FLT30.26163528
148CAMK40.25972103
149DAPK30.25802195
150ABL10.25536375
151ADRBK20.24773249
152MAP2K40.24632124
153PRKACA0.24215467
154PDK10.23554651
155PRKAA20.22940032
156RET0.22935715

Predicted pathways (KEGG)

RankGene SetZ-score
1Steroid biosynthesis_Homo sapiens_hsa001003.81604849
2Fatty acid elongation_Homo sapiens_hsa000623.78540044
3Terpenoid backbone biosynthesis_Homo sapiens_hsa009003.53443151
4Nitrogen metabolism_Homo sapiens_hsa009103.53215768
5Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010403.46845688
6Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.32556493
7Primary bile acid biosynthesis_Homo sapiens_hsa001203.26199459
8Ribosome_Homo sapiens_hsa030103.02769913
9Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.57275978
10Nicotine addiction_Homo sapiens_hsa050332.50138062
11Phototransduction_Homo sapiens_hsa047442.49171520
12Histidine metabolism_Homo sapiens_hsa003402.41679475
13Butanoate metabolism_Homo sapiens_hsa006502.39324693
14Cardiac muscle contraction_Homo sapiens_hsa042602.26132306
15Sulfur metabolism_Homo sapiens_hsa009202.22749122
16Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.21465279
17Huntingtons disease_Homo sapiens_hsa050162.05781285
18Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.03684816
19Neuroactive ligand-receptor interaction_Homo sapiens_hsa040802.02710003
20Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.00180896
21Basal transcription factors_Homo sapiens_hsa030221.97163723
22Vitamin B6 metabolism_Homo sapiens_hsa007501.91835824
23Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.87756258
24Complement and coagulation cascades_Homo sapiens_hsa046101.83192533
25Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.82456351
26Arginine biosynthesis_Homo sapiens_hsa002201.82001378
27Propanoate metabolism_Homo sapiens_hsa006401.81661646
28Peroxisome_Homo sapiens_hsa041461.73633506
29Tryptophan metabolism_Homo sapiens_hsa003801.71854509
30Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.70197478
31Fatty acid metabolism_Homo sapiens_hsa012121.69711925
32Tyrosine metabolism_Homo sapiens_hsa003501.65888632
33Ether lipid metabolism_Homo sapiens_hsa005651.65855866
34Steroid hormone biosynthesis_Homo sapiens_hsa001401.63306661
35Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.59610519
36Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.57103877
37Chemical carcinogenesis_Homo sapiens_hsa052041.54320420
38RNA polymerase_Homo sapiens_hsa030201.53997868
39Fatty acid degradation_Homo sapiens_hsa000711.52606928
40Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.52524267
41Taste transduction_Homo sapiens_hsa047421.52292541
42Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.50865251
43Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.44009502
44Morphine addiction_Homo sapiens_hsa050321.37119803
45Arginine and proline metabolism_Homo sapiens_hsa003301.35264330
46Retinol metabolism_Homo sapiens_hsa008301.31320966
47Homologous recombination_Homo sapiens_hsa034401.29960940
48Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.29727492
49Folate biosynthesis_Homo sapiens_hsa007901.28265965
50beta-Alanine metabolism_Homo sapiens_hsa004101.26382562
51PPAR signaling pathway_Homo sapiens_hsa033201.25300645
52Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.23817253
53Basal cell carcinoma_Homo sapiens_hsa052171.16961483
54Pentose and glucuronate interconversions_Homo sapiens_hsa000401.09798770
55Linoleic acid metabolism_Homo sapiens_hsa005911.09705609
56Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.06606259
57Pyruvate metabolism_Homo sapiens_hsa006201.05743703
58Bile secretion_Homo sapiens_hsa049761.05260890
59alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.04863555
60Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.03956255
61Hedgehog signaling pathway_Homo sapiens_hsa043401.03536125
62Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.01859440
63Olfactory transduction_Homo sapiens_hsa047400.99270992
64Circadian entrainment_Homo sapiens_hsa047130.96779955
65Glutathione metabolism_Homo sapiens_hsa004800.96670372
66Phenylalanine metabolism_Homo sapiens_hsa003600.93843466
67Staphylococcus aureus infection_Homo sapiens_hsa051500.92055109
68Vitamin digestion and absorption_Homo sapiens_hsa049770.91503535
69Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.88505468
70Insulin secretion_Homo sapiens_hsa049110.86837687
71RNA degradation_Homo sapiens_hsa030180.86817960
72Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.86426932
73ABC transporters_Homo sapiens_hsa020100.84812854
74Protein export_Homo sapiens_hsa030600.84696042
75Fat digestion and absorption_Homo sapiens_hsa049750.84463911
76Regulation of autophagy_Homo sapiens_hsa041400.84267473
77Sphingolipid metabolism_Homo sapiens_hsa006000.81970158
78Proteasome_Homo sapiens_hsa030500.78298766
79Cysteine and methionine metabolism_Homo sapiens_hsa002700.73596800
80Fanconi anemia pathway_Homo sapiens_hsa034600.72900676
81Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.71492634
82Oxidative phosphorylation_Homo sapiens_hsa001900.70562267
83Purine metabolism_Homo sapiens_hsa002300.67615538
84Calcium signaling pathway_Homo sapiens_hsa040200.67382708
85Collecting duct acid secretion_Homo sapiens_hsa049660.66974982
86Axon guidance_Homo sapiens_hsa043600.61367391
87Caffeine metabolism_Homo sapiens_hsa002320.60490123
88Nucleotide excision repair_Homo sapiens_hsa034200.60324771
89Metabolic pathways_Homo sapiens_hsa011000.58133797
90Fatty acid biosynthesis_Homo sapiens_hsa000610.57635740
91Dopaminergic synapse_Homo sapiens_hsa047280.55528563
92Drug metabolism - other enzymes_Homo sapiens_hsa009830.54207394
93Long-term depression_Homo sapiens_hsa047300.53236353
94Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.52995592
95One carbon pool by folate_Homo sapiens_hsa006700.52898062
96Glycerophospholipid metabolism_Homo sapiens_hsa005640.52271167
97Selenocompound metabolism_Homo sapiens_hsa004500.51995056
98Sulfur relay system_Homo sapiens_hsa041220.51645166
99Starch and sucrose metabolism_Homo sapiens_hsa005000.51047358
100TGF-beta signaling pathway_Homo sapiens_hsa043500.50489871
101Biosynthesis of amino acids_Homo sapiens_hsa012300.49697316
102Maturity onset diabetes of the young_Homo sapiens_hsa049500.49047358
103Prion diseases_Homo sapiens_hsa050200.47793929
104Glycerolipid metabolism_Homo sapiens_hsa005610.47719140
105Cholinergic synapse_Homo sapiens_hsa047250.46891824
106Carbon metabolism_Homo sapiens_hsa012000.44895648
107Parkinsons disease_Homo sapiens_hsa050120.40274854
108Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.40096983
109Cyanoamino acid metabolism_Homo sapiens_hsa004600.39407404
110Hippo signaling pathway_Homo sapiens_hsa043900.38432437
111Circadian rhythm_Homo sapiens_hsa047100.38151142
112Protein digestion and absorption_Homo sapiens_hsa049740.37878031
113Alzheimers disease_Homo sapiens_hsa050100.37548699
114Arachidonic acid metabolism_Homo sapiens_hsa005900.37443656
115Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.37017921
116Pyrimidine metabolism_Homo sapiens_hsa002400.36894212
117Amphetamine addiction_Homo sapiens_hsa050310.36366998
118Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.35896815
119Salivary secretion_Homo sapiens_hsa049700.34380492
120Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.34082733
121Renal cell carcinoma_Homo sapiens_hsa052110.33722981
122Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.32199319
123GABAergic synapse_Homo sapiens_hsa047270.30258032
124SNARE interactions in vesicular transport_Homo sapiens_hsa041300.25307571
1252-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.23164257
126Lysosome_Homo sapiens_hsa041420.21839398
127Lysine degradation_Homo sapiens_hsa003100.19932358
128Tight junction_Homo sapiens_hsa045300.19428105
129Ovarian steroidogenesis_Homo sapiens_hsa049130.18782626
130ECM-receptor interaction_Homo sapiens_hsa045120.15595467
131Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.15097852
132Pentose phosphate pathway_Homo sapiens_hsa000300.12757420
133Dorso-ventral axis formation_Homo sapiens_hsa043200.11938100
134Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.11320653
135Serotonergic synapse_Homo sapiens_hsa047260.10663903
136Glutamatergic synapse_Homo sapiens_hsa047240.10531774
137Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.09517125
138Sphingolipid signaling pathway_Homo sapiens_hsa040710.09486783
139Ras signaling pathway_Homo sapiens_hsa040140.09293350
140Vibrio cholerae infection_Homo sapiens_hsa051100.09002154
141Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.08397723
142Mineral absorption_Homo sapiens_hsa049780.08230887
143Cocaine addiction_Homo sapiens_hsa050300.07100560
144Malaria_Homo sapiens_hsa051440.05983112
145Vascular smooth muscle contraction_Homo sapiens_hsa042700.03585181

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