INSIG1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes an endoplasmic reticulum membrane protein that regulates cholesterol metabolism, lipogenesis, and glucose homeostasis. The encoded protein has six transmembrane helices which contain an effector protein binding site. It binds the sterol-sensing domains of sterol regulatory element-binding protein (SREBP) cleavage-activating protein (SCAP) and 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMG-CoA reductase), and is essential for the sterol-mediated trafficking of these two proteins. It promotes the endoplasmic reticulum retention of SCAP and the ubiquitin-mediated degradation of HMG-CoA reductase. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)6.78549550
2L-phenylalanine catabolic process (GO:0006559)6.78549550
3L-phenylalanine metabolic process (GO:0006558)6.40816066
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.40816066
5regulation of vitamin D biosynthetic process (GO:0060556)6.36777262
6alpha-linolenic acid metabolic process (GO:0036109)6.06707415
7aromatic amino acid family catabolic process (GO:0009074)5.89639276
8triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.84489771
9regulation of fever generation (GO:0031620)5.31085708
10bile acid biosynthetic process (GO:0006699)5.20816188
11regulation of vitamin metabolic process (GO:0030656)5.19518827
12sulfur amino acid catabolic process (GO:0000098)5.14168358
13indole-containing compound catabolic process (GO:0042436)5.13801318
14indolalkylamine catabolic process (GO:0046218)5.13801318
15tryptophan catabolic process (GO:0006569)5.13801318
16glyoxylate metabolic process (GO:0046487)5.02340290
17cysteine metabolic process (GO:0006534)5.01544876
18urea metabolic process (GO:0019627)5.00534707
19urea cycle (GO:0000050)5.00534707
20positive regulation of heat generation (GO:0031652)4.97769506
21high-density lipoprotein particle remodeling (GO:0034375)4.96275365
22protein carboxylation (GO:0018214)4.95555081
23peptidyl-glutamic acid carboxylation (GO:0017187)4.95555081
24kynurenine metabolic process (GO:0070189)4.92460359
25tryptophan metabolic process (GO:0006568)4.89585889
26negative regulation of fibrinolysis (GO:0051918)4.75691966
27complement activation, alternative pathway (GO:0006957)4.74668621
28tyrosine metabolic process (GO:0006570)4.72912608
29positive regulation of chemokine biosynthetic process (GO:0045080)4.69976462
30plasma lipoprotein particle clearance (GO:0034381)4.66219842
31lipopolysaccharide-mediated signaling pathway (GO:0031663)4.65345567
32nitrogen cycle metabolic process (GO:0071941)4.56830083
33bile acid metabolic process (GO:0008206)4.56618708
34regulation of fibrinolysis (GO:0051917)4.53188592
35oligosaccharide catabolic process (GO:0009313)4.50335488
36regulation of protein activation cascade (GO:2000257)4.48763333
37reverse cholesterol transport (GO:0043691)4.47442889
38regulation of triglyceride catabolic process (GO:0010896)4.46211589
39fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.44165190
40response to peptidoglycan (GO:0032494)4.43932265
41homocysteine metabolic process (GO:0050667)4.43444611
42aromatic amino acid family metabolic process (GO:0009072)4.40671910
43regulation of cytokine secretion involved in immune response (GO:0002739)4.38331199
44serine family amino acid catabolic process (GO:0009071)4.37395413
45regulation of cholesterol esterification (GO:0010872)4.36830879
46plasma lipoprotein particle remodeling (GO:0034369)4.35975994
47protein-lipid complex remodeling (GO:0034368)4.35975994
48macromolecular complex remodeling (GO:0034367)4.35975994
49triglyceride homeostasis (GO:0070328)4.32379942
50acylglycerol homeostasis (GO:0055090)4.32379942
51cellular glucuronidation (GO:0052695)4.26635534
52positive regulation of heterotypic cell-cell adhesion (GO:0034116)4.25029276
53positive regulation of membrane protein ectodomain proteolysis (GO:0051044)4.22109583
54regulation of complement activation (GO:0030449)4.18052135
55negative regulation of interleukin-12 production (GO:0032695)4.18005901
56regulation of chemokine biosynthetic process (GO:0045073)4.17917016
57regulation of mononuclear cell migration (GO:0071675)4.15220805
58regulation of chronic inflammatory response (GO:0002676)4.13174177
59very-low-density lipoprotein particle assembly (GO:0034379)4.12399525
60coenzyme catabolic process (GO:0009109)4.09774897
61regulation of cholesterol homeostasis (GO:2000188)4.08794396
62phospholipid efflux (GO:0033700)4.06365755
63alpha-amino acid catabolic process (GO:1901606)4.03808818
64glycosphingolipid catabolic process (GO:0046479)4.02658626
65acetyl-CoA metabolic process (GO:0006084)4.01591181
66negative regulation of cholesterol transport (GO:0032375)4.01467832
67negative regulation of sterol transport (GO:0032372)4.01467832
68amino-acid betaine metabolic process (GO:0006577)4.01147825
69cholesterol efflux (GO:0033344)3.99556535
70ethanol oxidation (GO:0006069)3.97234146
71regulation of podosome assembly (GO:0071801)3.97107529
72regulation of cholesterol biosynthetic process (GO:0045540)3.96134997
73intestinal cholesterol absorption (GO:0030299)3.95424878
74serine family amino acid biosynthetic process (GO:0009070)3.91261913
75plasma lipoprotein particle assembly (GO:0034377)3.90792431
76regulation of membrane protein ectodomain proteolysis (GO:0051043)3.84728352
77cellular modified amino acid catabolic process (GO:0042219)3.84500671
78glycine metabolic process (GO:0006544)3.83508533
79regulation of heat generation (GO:0031650)3.81484545
80glucuronate metabolic process (GO:0019585)3.81374263
81uronic acid metabolic process (GO:0006063)3.81374263
82bile acid and bile salt transport (GO:0015721)3.81232402
83serine family amino acid metabolic process (GO:0009069)3.80359367
84positive regulation of lipid catabolic process (GO:0050996)3.80299749
85cellular amino acid catabolic process (GO:0009063)3.79072523
86low-density lipoprotein particle clearance (GO:0034383)3.78909842
87lysine metabolic process (GO:0006553)3.78776751
88lysine catabolic process (GO:0006554)3.78776751
89cellular ketone body metabolic process (GO:0046950)3.75693676
90phospholipid homeostasis (GO:0055091)3.75414778
91low-density lipoprotein particle remodeling (GO:0034374)3.74660180
92indolalkylamine metabolic process (GO:0006586)3.73643051
93activation of MAPKKK activity (GO:0000185)3.72321076
94amine catabolic process (GO:0009310)3.69692927
95cellular biogenic amine catabolic process (GO:0042402)3.69692927
96fatty-acyl-CoA biosynthetic process (GO:0046949)3.68122031
97positive regulation of fatty acid beta-oxidation (GO:0032000)3.67541884
98regulation of T-helper 1 cell differentiation (GO:0045625)3.64987315
99positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.64145592
100regulation of cholesterol metabolic process (GO:0090181)3.63592887
101glycolipid catabolic process (GO:0019377)3.63456434
102linoleic acid metabolic process (GO:0043651)3.63104844
103glutamate metabolic process (GO:0006536)3.59627077
104short-chain fatty acid metabolic process (GO:0046459)3.56033759
105cholesterol homeostasis (GO:0042632)3.55653210
106plasma lipoprotein particle organization (GO:0071827)3.55466431
107NIK/NF-kappaB signaling (GO:0038061)3.55356817
108imidazole-containing compound metabolic process (GO:0052803)3.55195355
109protein-lipid complex assembly (GO:0065005)3.55102533
110benzene-containing compound metabolic process (GO:0042537)3.54280901
111response to nitrosative stress (GO:0051409)3.53568674
112sterol homeostasis (GO:0055092)3.51399318
113fibrinolysis (GO:0042730)3.48903033
114regulation of cholesterol storage (GO:0010885)3.48426729
115long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)3.48132718
116negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)3.48126492
117lipoprotein metabolic process (GO:0042157)3.48051100
118cofactor catabolic process (GO:0051187)3.47825245
119positive regulation of lipoprotein lipase activity (GO:0051006)3.47289482
120positive regulation of triglyceride lipase activity (GO:0061365)3.47289482
121ketone body metabolic process (GO:1902224)3.46154752
122positive regulation of triglyceride metabolic process (GO:0090208)3.45666898
123cellular response to thyroid hormone stimulus (GO:0097067)3.45463789
124organic acid catabolic process (GO:0016054)3.42039614
125carboxylic acid catabolic process (GO:0046395)3.42039614
126very long-chain fatty acid metabolic process (GO:0000038)3.40761396
127* cholesterol biosynthetic process (GO:0006695)3.39474489
128positive regulation of nitric oxide biosynthetic process (GO:0045429)3.37316976
129monocyte chemotaxis (GO:0002548)3.33132196
130cellular response to arsenic-containing substance (GO:0071243)3.33085442
131regulation of heterotypic cell-cell adhesion (GO:0034114)3.28721127
132regulation of interferon-alpha production (GO:0032647)3.27756345
133regulation of nitric oxide biosynthetic process (GO:0045428)3.27120176
134negative regulation of lipid storage (GO:0010888)3.26674064
135myeloid dendritic cell differentiation (GO:0043011)3.23946550
136cellular response to lipopolysaccharide (GO:0071222)3.22521144
137regulation of immunoglobulin secretion (GO:0051023)3.21082744
138branching involved in labyrinthine layer morphogenesis (GO:0060670)3.15024138
139negative regulation of erythrocyte differentiation (GO:0045647)3.13975543
140T-helper 1 type immune response (GO:0042088)3.12178726
141macrophage activation involved in immune response (GO:0002281)3.11053508
142ceramide catabolic process (GO:0046514)3.10601288
143negative regulation of cytokine production involved in immune response (GO:0002719)3.07368336
144germinal center formation (GO:0002467)3.06375062
145negative regulation of myeloid cell apoptotic process (GO:0033033)3.05990879
146cellular response to molecule of bacterial origin (GO:0071219)3.05723545
147cellular response to nicotine (GO:0071316)3.05150147
148positive regulation of NF-kappaB import into nucleus (GO:0042346)3.04942966
149response to thyroid hormone (GO:0097066)3.04795591
150positive regulation of lipid storage (GO:0010884)3.01969671
151negative regulation of nitric oxide biosynthetic process (GO:0045019)2.97280149
152membrane lipid catabolic process (GO:0046466)2.95734963
153positive regulation of acute inflammatory response (GO:0002675)2.95146254
154positive regulation of interleukin-6 production (GO:0032755)2.93736297
155adhesion of symbiont to host (GO:0044406)2.92313540
156virion attachment to host cell (GO:0019062)2.92207666
157adhesion of symbiont to host cell (GO:0044650)2.92207666
158positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.90474034
159lipid storage (GO:0019915)2.89642853
160cellular response to type I interferon (GO:0071357)2.79015007
161type I interferon signaling pathway (GO:0060337)2.79015007
162sphingolipid catabolic process (GO:0030149)2.78273702
163fat-soluble vitamin biosynthetic process (GO:0042362)2.77428709
164positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)2.77117342
165response to protozoan (GO:0001562)2.75369022
166response to type I interferon (GO:0034340)2.74751451
167regulation of T-helper 2 cell differentiation (GO:0045628)2.73331339
168response to muramyl dipeptide (GO:0032495)2.73181154
169cellular response to biotic stimulus (GO:0071216)2.68027293
170positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.68016847
171regulation of NF-kappaB import into nucleus (GO:0042345)2.67119168
172myeloid dendritic cell activation (GO:0001773)2.66016742
173regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.63568210
174regulation of NFAT protein import into nucleus (GO:0051532)2.63355756
175acute-phase response (GO:0006953)2.63210721
176positive regulation of extracellular matrix organization (GO:1903055)2.62310677
177regulation of toll-like receptor 4 signaling pathway (GO:0034143)2.62009476
178positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.61600308
179positive regulation of p38MAPK cascade (GO:1900745)2.59600715
180modulation of growth of symbiont involved in interaction with host (GO:0044144)2.59521247
181regulation of growth of symbiont in host (GO:0044126)2.59521247
182negative regulation of growth of symbiont in host (GO:0044130)2.59521247
183negative regulation of growth of symbiont involved in interaction with host (GO:0044146)2.59521247
184regulation of lipid storage (GO:0010883)2.57848296
185positive regulation of interferon-alpha production (GO:0032727)2.56738823
186regulation of interleukin-2 biosynthetic process (GO:0045076)2.56483607
187regulation of interleukin-8 biosynthetic process (GO:0045414)2.56184491
188positive regulation of cellular amide metabolic process (GO:0034250)2.55306304
189protein localization to endosome (GO:0036010)2.54601508
190neutrophil activation involved in immune response (GO:0002283)2.53520794
191detection of molecule of bacterial origin (GO:0032490)2.51031474
192positive regulation of gamma-delta T cell activation (GO:0046645)2.48648773
193JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.48425250

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* RXR_22158963_ChIP-Seq_LIVER_Mouse7.71267740
2PPARA_22158963_ChIP-Seq_LIVER_Mouse6.51750940
3EGR1_23403033_ChIP-Seq_LIVER_Mouse6.19216936
4* LXR_22158963_ChIP-Seq_LIVER_Mouse6.18906576
5PPARG_19300518_ChIP-PET_3T3-L1_Mouse5.81855277
6FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.99784066
7CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.66659159
8EGR1_19374776_ChIP-ChIP_THP-1_Human4.34816436
9NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.72629251
10CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.59580671
11IRF8_21731497_ChIP-ChIP_J774_Mouse3.58838247
12BP1_19119308_ChIP-ChIP_Hs578T_Human3.07052861
13MYB_21317192_ChIP-Seq_ERMYB_Mouse2.75201439
14TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.72459789
15CLOCK_20551151_ChIP-Seq_293T_Human2.67129446
16STAT4_19710469_ChIP-ChIP_TH1__Mouse2.36094667
17MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.29114985
18IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.13319532
19STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.09991006
20* VDR_21846776_ChIP-Seq_THP-1_Human2.09258633
21ESR1_17901129_ChIP-ChIP_LIVER_Mouse10.6886361
22TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.93820235
23HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.86795242
24* VDR_24763502_ChIP-Seq_THP-1_Human1.85651814
25FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.84862073
26STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.81285745
27STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.75023838
28* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.71572206
29SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.70760036
30ELK3_25401928_ChIP-Seq_HUVEC_Human1.67495569
31MYC_22102868_ChIP-Seq_BL_Human1.67367296
32* TFEB_21752829_ChIP-Seq_HELA_Human1.60285688
33FOXA2_19822575_ChIP-Seq_HepG2_Human1.59871092
34* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.59355181
35SCL_19346495_ChIP-Seq_HPC-7_Human1.59210556
36SPI1_23127762_ChIP-Seq_K562_Human1.49102042
37KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.47444252
38ZNF263_19887448_ChIP-Seq_K562_Human1.46804909
39STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.46188404
40* VDR_24787735_ChIP-Seq_THP-1_Human1.42526739
41Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.42108146
42* NCOR1_26117541_ChIP-Seq_K562_Human1.39513331
43MAF_26560356_Chip-Seq_TH1_Human1.39498188
44NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.38817969
45PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.37405363
46SALL4_18804426_ChIP-ChIP_XEN_Mouse1.36097960
47* PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.35831541
48* LXR_22292898_ChIP-Seq_THP-1_Human1.35534002
49TCF7_22412390_ChIP-Seq_EML_Mouse1.34666400
50* SPI1_23547873_ChIP-Seq_NB4_Human1.34011204
51RUNX1_22412390_ChIP-Seq_EML_Mouse1.33967991
52CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.33830198
53KDM2B_26808549_Chip-Seq_SUP-B15_Human1.33201899
54HNF4A_19822575_ChIP-Seq_HepG2_Human1.31537163
55E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.29742037
56SOX2_27498859_Chip-Seq_STOMACH_Mouse1.28767762
57CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.27997615
58RARG_19884340_ChIP-ChIP_MEFs_Mouse1.27744183
59* MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.24744222
60NRF2_20460467_ChIP-Seq_MEFs_Mouse1.24438454
61NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.24438454
62PU_27001747_Chip-Seq_BMDM_Mouse1.23597468
63CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.23132757
64KDM2B_26808549_Chip-Seq_DND41_Human1.22060157
65FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.19097685
66STAT3_1855785_ChIP-Seq_MESCs_Mouse1.18642043
67* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.17678681
68IRF8_22096565_ChIP-ChIP_GC-B_Human1.16933028
69GATA2_22383799_ChIP-Seq_G1ME_Mouse1.14372226
70HTT_18923047_ChIP-ChIP_STHdh_Human1.14089430
71VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.13999237
72KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.12319946
73KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.12319946
74KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.12319946
75SMAD_19615063_ChIP-ChIP_OVARY_Human1.12285677
76KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.11854337
77SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.10222303
78GATA1_22383799_ChIP-Seq_G1ME_Mouse1.06472156
79SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.05787294
80RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.04036343
81BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.02861806
82* GATA4_25053715_ChIP-Seq_YYC3_Human1.02018827
83HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.01746849
84NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.00998381
85TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.99787169
86UBF1/2_26484160_Chip-Seq_HMECs_Human0.98835723
87LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.98770818
88AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.98562657
89* KDM2B_26808549_Chip-Seq_K562_Human0.98558167
90TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.98454136
91ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.96680901
92* CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.96651700
93* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.96631633
94* SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.96024613
95ESR2_21235772_ChIP-Seq_MCF-7_Human0.95967549
96SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.95268730
97* RACK7_27058665_Chip-Seq_MCF-7_Human0.94970424
98* CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.94906291
99ESR1_21235772_ChIP-Seq_MCF-7_Human0.94608685
100GATA1_22025678_ChIP-Seq_K562_Human0.94600442
101* PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.92736891
102ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.91966252
103* PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.91906636
104* UTX_26944678_Chip-Seq_JUKART_Human0.91311377
105MAF_26560356_Chip-Seq_TH2_Human0.91024518
106MYB_26560356_Chip-Seq_TH1_Human0.90237784
107* GATA1_19941827_ChIP-Seq_MEL_Mouse0.89825498
108* FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.89494849
109RXRA_24833708_ChIP-Seq_LIVER_Mouse0.86550742
110PPAR_26484153_Chip-Seq_NCI-H1993_Human0.83934810
111FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.83665184
112* TRIM28_21343339_ChIP-Seq_HEK293_Human0.83472572
113FOXO3_23340844_ChIP-Seq_DLD1_Human0.82194661
114FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.81155625
115SOX2_20726797_ChIP-Seq_SW620_Human0.80578868
116FOXA1_25552417_ChIP-Seq_VCAP_Human0.79915017
117IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.78352627
118PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.76971061
119TP63_17297297_ChIP-ChIP_HaCaT_Human0.75813089
120NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.74888499
121THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.73744624
122AUTS2_25519132_ChIP-Seq_293T-REX_Human0.73203038
123ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.73168430
124NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.72533166
125* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.71225001
126ESR1_15608294_ChIP-ChIP_MCF-7_Human0.71191655
127ESR1_20079471_ChIP-ChIP_T-47D_Human0.70160488
128FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.68535836
129ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.67347137
130EGR1_19032775_ChIP-ChIP_M12_Human0.66171234
131FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.64986130
132GATA6_25053715_ChIP-Seq_YYC3_Human0.62873245
133* GATA3_24758297_ChIP-Seq_MCF-7_Human0.62154476
134* PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.61847521
135* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.61845617
136HIF1A_21447827_ChIP-Seq_MCF-7_Human0.61188362
137SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.60504690
138SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.57408892
139SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.57068118
140CJUN_26792858_Chip-Seq_BT549_Human0.56424401
141KAP1_22055183_ChIP-Seq_ESCs_Mouse0.55571880
142PIAS1_25552417_ChIP-Seq_VCAP_Human0.54904076
143ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.53133287
144CDX2_20551321_ChIP-Seq_CACO-2_Human0.53090087
145CBP_21632823_ChIP-Seq_H3396_Human0.52938596
146AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.51557957
147RARA_24833708_ChIP-Seq_LIVER_Mouse0.51294866
148* TP63_23658742_ChIP-Seq_EP156T_Human0.50339993
149ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.49088743
150GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.46805987
151* ZNF217_24962896_ChIP-Seq_MCF-7_Human0.45567320
152CEBPB_22108803_ChIP-Seq_LS180_Human0.45363214
153CDX2_19796622_ChIP-Seq_MESCs_Mouse0.44685199
154CDX2_22108803_ChIP-Seq_LS180_Human0.44628905
155GATA2_19941826_ChIP-Seq_K562_Human0.44023588
156* GATA1_19941826_ChIP-Seq_K562_Human0.42916018
157IRF8_27001747_Chip-Seq_BMDM_Mouse0.42144201
158PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.41889077
159BRD4_27068464_Chip-Seq_AML-cells_Mouse0.41873756
160KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.41859720
161BCAT_22108803_ChIP-Seq_LS180_Human0.41692206
162ESET_19884257_ChIP-Seq_ESCs_Mouse0.40859682
163AR_20517297_ChIP-Seq_VCAP_Human0.40088282
164RARB_24833708_ChIP-Seq_LIVER_Mouse0.39944520
165CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.39814637
166* GATA2_21666600_ChIP-Seq_HMVEC_Human0.39531331

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1* MP0002139_abnormal_hepatobiliary_system7.41309515
2MP0005360_urolithiasis6.72361551
3MP0005085_abnormal_gallbladder_physiolo5.74982130
4MP0005365_abnormal_bile_salt5.72584509
5MP0003303_peritoneal_inflammation5.53203517
6MP0008875_abnormal_xenobiotic_pharmacok4.30498025
7MP0003806_abnormal_nucleotide_metabolis3.88858355
8MP0009840_abnormal_foam_cell3.74402697
9MP0010329_abnormal_lipoprotein_level3.64140319
10MP0003252_abnormal_bile_duct3.41358347
11MP0005083_abnormal_biliary_tract3.38289229
12MP0006082_CNS_inflammation3.07218066
13MP0002148_abnormal_hypersensitivity_rea2.95360118
14MP0004510_myositis2.89180676
15MP0009785_altered_susceptibility_to2.85555266
16MP0003195_calcinosis2.85321685
17MP0005332_abnormal_amino_acid2.49498947
18MP0001666_abnormal_nutrient_absorption2.47183745
19MP0000343_altered_response_to2.34459391
20* MP0002118_abnormal_lipid_homeostasis2.31052099
21MP0005000_abnormal_immune_tolerance2.24311319
22* MP0000609_abnormal_liver_physiology2.21551651
23MP0003191_abnormal_cellular_cholesterol2.20144243
24MP0004947_skin_inflammation2.14566870
25MP0002419_abnormal_innate_immunity2.09699340
26MP0003868_abnormal_feces_composition1.96158252
27MP0001790_abnormal_immune_system1.93746011
28MP0005387_immune_system_phenotype1.93746011
29MP0001835_abnormal_antigen_presentation1.86934263
30MP0003172_abnormal_lysosome_physiology1.86360705
31MP0005025_abnormal_response_to1.85386082
32MP0008004_abnormal_stomach_pH1.85025126
33MP0001853_heart_inflammation1.78452410
34MP0003705_abnormal_hypodermis_morpholog1.78140800
35MP0009278_abnormal_bone_marrow1.76833732
36MP0001545_abnormal_hematopoietic_system1.72782349
37MP0005397_hematopoietic_system_phenotyp1.72782349
38MP0004019_abnormal_vitamin_homeostasis1.72729597
39MP0005671_abnormal_response_to1.70576980
40MP0002452_abnormal_antigen_presenting1.64562972
41MP0002332_abnormal_exercise_endurance1.64100126
42MP0002723_abnormal_immune_serum1.61655111
43MP0005319_abnormal_enzyme/_coenzyme1.61570665
44MP0003186_abnormal_redox_activity1.55255104
45MP0003011_delayed_dark_adaptation1.52977912
46MP0001845_abnormal_inflammatory_respons1.49847641
47MP0005408_hypopigmentation1.48710802
48MP0005670_abnormal_white_adipose1.47341404
49MP0005167_abnormal_blood-brain_barrier1.47171694
50MP0001764_abnormal_homeostasis1.46571228
51MP0001800_abnormal_humoral_immune1.45218908
52MP0002138_abnormal_hepatobiliary_system1.45079874
53MP0003448_altered_tumor_morphology1.44297510
54MP0000858_altered_metastatic_potential1.42442123
55MP0005584_abnormal_enzyme/coenzyme_acti1.42023379
56MP0002998_abnormal_bone_remodeling1.39912785
57MP0009333_abnormal_splenocyte_physiolog1.38038293
58MP0009697_abnormal_copulation1.35727298
59MP0010155_abnormal_intestine_physiology1.35289239
60MP0005166_decreased_susceptibility_to1.29703370
61MP0008438_abnormal_cutaneous_collagen1.28863721
62MP0006054_spinal_hemorrhage1.25801602
63MP0002420_abnormal_adaptive_immunity1.23214592
64MP0001819_abnormal_immune_cell1.23013178
65MP0002405_respiratory_system_inflammati1.20178122
66MP0004130_abnormal_muscle_cell1.19622012
67MP0005310_abnormal_salivary_gland1.18367579
68MP0000604_amyloidosis1.17969992
69MP0005220_abnormal_exocrine_pancreas1.17222063
70* MP0000598_abnormal_liver_morphology1.16702707
71MP0002971_abnormal_brown_adipose1.16371661
72MP0000685_abnormal_immune_system1.16095394
73MP0005666_abnormal_adipose_tissue1.15342486
74MP0002254_reproductive_system_inflammat1.13130344
75MP0005647_abnormal_sex_gland1.13029079
76MP0003690_abnormal_glial_cell1.12855202
77MP0009643_abnormal_urine_homeostasis1.08242712
78MP0010307_abnormal_tumor_latency1.07518845
79MP0003656_abnormal_erythrocyte_physiolo1.06506887
80MP0005334_abnormal_fat_pad1.05478771
81MP0005451_abnormal_body_composition1.02154188
82MP0002876_abnormal_thyroid_physiology1.01878669
83MP0005076_abnormal_cell_differentiation1.01267574
84MP0009763_increased_sensitivity_to1.00456527
85MP0002078_abnormal_glucose_homeostasis0.98573131
86MP0003091_abnormal_cell_migration0.97753560
87MP0002877_abnormal_melanocyte_morpholog0.95982403
88MP0010352_gastrointestinal_tract_polyps0.93637056
89MP0004185_abnormal_adipocyte_glucose0.93630506
90MP0000920_abnormal_myelination0.93024565
91MP0003221_abnormal_cardiomyocyte_apopto0.90602832
92MP0000716_abnormal_immune_system0.89938720
93MP0009764_decreased_sensitivity_to0.85969926
94MP0003950_abnormal_plasma_membrane0.85732904
95MP0001661_extended_life_span0.84017585
96MP0004808_abnormal_hematopoietic_stem0.81213690
97MP0005248_abnormal_Harderian_gland0.80843075
98MP0003329_amyloid_beta_deposits0.80189943
99MP0005535_abnormal_body_temperature0.80000534
100* MP0009642_abnormal_blood_homeostasis0.79860875
101MP0008874_decreased_physiological_sensi0.77764548
102MP0002398_abnormal_bone_marrow0.77649686
103MP0009765_abnormal_xenobiotic_induced0.77229970
104MP0005448_abnormal_energy_balance0.76971155
105MP0003724_increased_susceptibility_to0.76792192
106MP0005165_increased_susceptibility_to0.76466518
107MP0008260_abnormal_autophagy0.75772616
108MP0008469_abnormal_protein_level0.75725993
109MP0001727_abnormal_embryo_implantation0.75558813
110MP0004782_abnormal_surfactant_physiolog0.75537505
111MP0001881_abnormal_mammary_gland0.75146732
112MP0002429_abnormal_blood_cell0.72846254
113MP0003718_maternal_effect0.72842531
114MP0005058_abnormal_lysosome_morphology0.71517868
115MP0005023_abnormal_wound_healing0.71206822
116MP0000689_abnormal_spleen_morphology0.70549294
117MP0005395_other_phenotype0.69794788
118MP0005376_homeostasis/metabolism_phenot0.68987707
119MP0000639_abnormal_adrenal_gland0.68342954
120MP0002722_abnormal_immune_system0.67113597
121MP0001542_abnormal_bone_strength0.66892821
122MP0005084_abnormal_gallbladder_morpholo0.66082115
123MP0009115_abnormal_fat_cell0.62365308
124MP0003436_decreased_susceptibility_to0.61459770
125MP0009384_cardiac_valve_regurgitation0.60119365
126MP0002970_abnormal_white_adipose0.60072417
127MP0005375_adipose_tissue_phenotype0.58732179
128MP0005636_abnormal_mineral_homeostasis0.56607750
129MP0001243_abnormal_dermal_layer0.54888084
130MP0010368_abnormal_lymphatic_system0.53495224
131MP0003953_abnormal_hormone_level0.52585821
132MP0009053_abnormal_anal_canal0.51829310
133MP0002168_other_aberrant_phenotype0.51239120
134MP0000647_abnormal_sebaceous_gland0.51069170
135MP0004381_abnormal_hair_follicle0.50945082
136MP0003959_abnormal_lean_body0.50490038
137MP0009672_abnormal_birth_weight0.50443667
138MP0001177_atelectasis0.50127633
139MP0002060_abnormal_skin_morphology0.49752977
140MP0000427_abnormal_hair_cycle0.48728010
141MP0003300_gastrointestinal_ulcer0.48684070
142MP0001756_abnormal_urination0.48169263
143MP0001944_abnormal_pancreas_morphology0.47699688
144MP0005164_abnormal_response_to0.47493654
145MP0002090_abnormal_vision0.45715780
146MP0009780_abnormal_chondrocyte_physiolo0.44774807
147MP0005266_abnormal_metabolism0.44525355
148MP0000371_diluted_coat_color0.44419005
149MP0001324_abnormal_eye_pigmentation0.44193161
150MP0003453_abnormal_keratinocyte_physiol0.42790833
151MP0006036_abnormal_mitochondrial_physio0.41659109
152MP0003075_altered_response_to0.39956268
153MP0001533_abnormal_skeleton_physiology0.39298536
154MP0005464_abnormal_platelet_physiology0.39269076
155MP0000372_irregular_coat_pigmentation0.38962053
156MP0002295_abnormal_pulmonary_circulatio0.36774501
157MP0008873_increased_physiological_sensi0.35332707

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of glycolipid metabolism (HP:0010969)7.06804354
2Abnormality of liposaccharide metabolism (HP:0010968)7.06804354
3Abnormality of glycosphingolipid metabolism (HP:0004343)7.06804354
4Intrahepatic cholestasis (HP:0001406)7.02440585
5Abnormality of aromatic amino acid family metabolism (HP:0004338)6.69190406
6Deep venous thrombosis (HP:0002625)6.55687291
7Xanthomatosis (HP:0000991)6.44244491
8Abnormality of monocarboxylic acid metabolism (HP:0010996)5.84242650
9Prolonged partial thromboplastin time (HP:0003645)5.69748029
10Hypobetalipoproteinemia (HP:0003563)5.62936745
11Vacuolated lymphocytes (HP:0001922)5.49941531
12Hyperlipoproteinemia (HP:0010980)5.20043207
13Epidermoid cyst (HP:0200040)5.15192177
14Complement deficiency (HP:0004431)4.66057290
15Hypolipoproteinemia (HP:0010981)4.63079696
16Dysostosis multiplex (HP:0000943)4.48519314
17Loss of speech (HP:0002371)4.46411034
18Increased cerebral lipofuscin (HP:0011813)4.38097178
19Hypoalphalipoproteinemia (HP:0003233)4.35343054
20Hyperglycinemia (HP:0002154)4.29263900
21Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.29164819
22Disinhibition (HP:0000734)4.20225695
23Abnormality of glutamine family amino acid metabolism (HP:0010902)4.15277899
24Joint hemorrhage (HP:0005261)4.15135307
25Hyperammonemia (HP:0001987)4.11661408
26Abnormality of the common coagulation pathway (HP:0010990)4.10643359
27Hyperglycinuria (HP:0003108)4.08534143
28Abnormality of serine family amino acid metabolism (HP:0010894)4.07130656
29Abnormality of glycine metabolism (HP:0010895)4.07130656
30Abnormality of macrophages (HP:0004311)4.04750195
31Hypoglycemic coma (HP:0001325)4.04064136
32Fat malabsorption (HP:0002630)4.01989046
33Abnormality of methionine metabolism (HP:0010901)3.91531237
34Abnormality of sulfur amino acid metabolism (HP:0004339)3.89534635
35Ketosis (HP:0001946)3.89141048
36Nuclear cataract (HP:0100018)3.84240892
37Myocardial infarction (HP:0001658)3.76739951
38Abnormality of the intrinsic pathway (HP:0010989)3.70186513
39Neurofibrillary tangles (HP:0002185)3.68507218
40Abnormality of aspartate family amino acid metabolism (HP:0010899)3.68123627
41Hypercholesterolemia (HP:0003124)3.60843158
42Abnormality of complement system (HP:0005339)3.55571569
43Mutism (HP:0002300)3.53451266
44Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.43560178
45Conjugated hyperbilirubinemia (HP:0002908)3.41903805
46Increased neuronal autofluorescent lipopigment (HP:0002074)3.34066360
47Skin nodule (HP:0200036)3.20090289
48Abnormality of glycosaminoglycan metabolism (HP:0004371)3.19760916
49Abnormality of mucopolysaccharide metabolism (HP:0011020)3.19760916
50Abnormality of polysaccharide metabolism (HP:0011012)3.19760916
51Abnormality of fatty-acid metabolism (HP:0004359)3.15416901
52Autoimmune thrombocytopenia (HP:0001973)3.14899859
53Optic neuritis (HP:0100653)3.09890797
54Retrobulbar optic neuritis (HP:0100654)3.09890797
55Urinary glycosaminoglycan excretion (HP:0003541)3.09068772
56Mucopolysacchariduria (HP:0008155)3.09068772
57Increased serum ferritin (HP:0003281)3.07883769
58Steatorrhea (HP:0002570)3.07759445
59Axonal loss (HP:0003447)3.04165466
60Abnormality of pyrimidine metabolism (HP:0004353)3.03183532
61Cerebral inclusion bodies (HP:0100314)3.00932739
62Orchitis (HP:0100796)3.00658218
63Ketoacidosis (HP:0001993)3.00229675
64Cholecystitis (HP:0001082)2.99483066
65Abnormal gallbladder physiology (HP:0012438)2.99483066
66Hypoglycemic seizures (HP:0002173)2.95357211
67Hyperbilirubinemia (HP:0002904)2.88040769
68Abnormality of serum amino acid levels (HP:0003112)2.86240076
69Hepatocellular carcinoma (HP:0001402)2.83867371
70Nausea (HP:0002018)2.83549909
71Apathy (HP:0000741)2.79608658
72Neuronal loss in central nervous system (HP:0002529)2.77401509
73Diminished motivation (HP:0000745)2.72382754
74Abnormality of proline metabolism (HP:0010907)2.69704917
75Hydroxyprolinuria (HP:0003080)2.69704917
76Recurrent bacterial skin infections (HP:0005406)2.68344194
77Acanthocytosis (HP:0001927)2.67558823
78Abnormality of nucleobase metabolism (HP:0010932)2.64724745
79Mediastinal lymphadenopathy (HP:0100721)2.60303886
80Recurrent abscess formation (HP:0002722)2.56506105
81Purpura (HP:0000979)2.54287315
82Delayed CNS myelination (HP:0002188)2.50579260
83Stomatitis (HP:0010280)2.46488598
84Abnormality of purine metabolism (HP:0004352)2.45495352
85Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.42768020
86Tetraparesis (HP:0002273)2.42718705
87Spontaneous abortion (HP:0005268)2.41953979
88Hepatosplenomegaly (HP:0001433)2.41001678
89Upper motor neuron abnormality (HP:0002127)2.40769725
90Eczematoid dermatitis (HP:0000976)2.39566744
91Abnormality of the vasculature of the conjunctiva (HP:0008054)2.39548618
92Mitral stenosis (HP:0001718)2.38379662
93Progressive neurologic deterioration (HP:0002344)2.37166362
94Abnormality of iron homeostasis (HP:0011031)2.36146392
95Abnormal cartilage morphology (HP:0002763)2.33626344
96Prolonged neonatal jaundice (HP:0006579)2.33294217
97Vascular calcification (HP:0004934)2.33188548
98Irritability (HP:0000737)2.33180305
99Myositis (HP:0100614)2.31674467
100Pancreatitis (HP:0001733)2.31472066
101Hyperinsulinemic hypoglycemia (HP:0000825)2.27365629
102Keratoconjunctivitis sicca (HP:0001097)2.26439811
103Gangrene (HP:0100758)2.26074625
104Recurrent gram-negative bacterial infections (HP:0005420)2.24570385
105Parakeratosis (HP:0001036)2.23328239
106Systemic lupus erythematosus (HP:0002725)2.21651326
107Vertebral compression fractures (HP:0002953)2.20529134
108Metabolic acidosis (HP:0001942)2.19316427
109Dicarboxylic aciduria (HP:0003215)2.18930352
110Abnormality of dicarboxylic acid metabolism (HP:0010995)2.18930352
111Esophageal varix (HP:0002040)2.18538175
112Hypochromic microcytic anemia (HP:0004840)2.18073313
113Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.18035815
114Spastic diplegia (HP:0001264)2.17695672
115Hyperglycemia (HP:0003074)2.17640139
116Abnormal gallbladder morphology (HP:0012437)2.15943381
117Protuberant abdomen (HP:0001538)2.14824761
118Cardiovascular calcification (HP:0011915)2.14446143
119Turricephaly (HP:0000262)2.12273180
120Amyloidosis (HP:0011034)2.12248512
121Lethargy (HP:0001254)2.09735367
122Inappropriate behavior (HP:0000719)2.09227118
123Metaphyseal irregularity (HP:0003025)2.08153615
124Cortical dysplasia (HP:0002539)2.07844059
125Late onset (HP:0003584)2.07029217
126Brushfield spots (HP:0001088)2.06556785
127Personality changes (HP:0000751)2.05038037
128Generalized aminoaciduria (HP:0002909)2.03535754
129Peripheral demyelination (HP:0011096)2.03533475
130Hemorrhage of the eye (HP:0011885)2.02155157
131Symptomatic seizures (HP:0011145)2.00657635
132Bone pain (HP:0002653)2.00640641
133Gingival bleeding (HP:0000225)2.00481383
134Cardiomegaly (HP:0001640)1.99608974
135Hypophosphatemic rickets (HP:0004912)1.99064262
136Glomerulonephritis (HP:0000099)1.98213773
137Interstitial pulmonary disease (HP:0006530)1.98072140
138Abnormal enzyme/coenzyme activity (HP:0012379)1.97547159
139Rickets (HP:0002748)1.97351606
140Polycythemia (HP:0001901)1.96852806
141Agnosia (HP:0010524)1.96148399
142Sensorimotor neuropathy (HP:0007141)1.96039671
143Segmental peripheral demyelination/remyelination (HP:0003481)1.95185197
144Keratoconjunctivitis (HP:0001096)1.94759663
145Hypertriglyceridemia (HP:0002155)1.94593181
146Autoimmune hemolytic anemia (HP:0001890)1.89570892
147Abnormal tarsal ossification (HP:0008369)1.87992349
148Pathologic fracture (HP:0002756)1.86311781
149Petechiae (HP:0000967)1.86281822
150Epiphyseal stippling (HP:0010655)1.86225996
151Recurrent viral infections (HP:0004429)1.86143238
152Thoracic kyphosis (HP:0002942)1.86108894
153J-shaped sella turcica (HP:0002680)1.86044745
154Abnormality of transition element cation homeostasis (HP:0011030)1.85220232
155Elevated alkaline phosphatase (HP:0003155)1.84928382
156Supranuclear gaze palsy (HP:0000605)1.84466472
157Dementia (HP:0000726)1.83825192
158Polyneuropathy (HP:0001271)1.82803052
159Cholelithiasis (HP:0001081)1.81612926
160Abnormality of the gallbladder (HP:0005264)1.81257892
161Abnormality of the lumbar spine (HP:0100712)1.80819402
162Increased mean platelet volume (HP:0011877)1.79657098
163Thrombophlebitis (HP:0004418)1.79084689
164Hypertensive crisis (HP:0100735)1.78699113
165Pulmonary infiltrates (HP:0002113)1.78587053
166Enlarged kidneys (HP:0000105)1.78276342
167Abnormality of the periventricular white matter (HP:0002518)1.78110887
168Abnormality of the Achilles tendon (HP:0005109)1.77752087
169Back pain (HP:0003418)1.77730849
170Menorrhagia (HP:0000132)1.76808734
171Renal cortical cysts (HP:0000803)1.75714154
172Opisthotonus (HP:0002179)1.75333362
173Malnutrition (HP:0004395)1.73700979
174Abnormality of alkaline phosphatase activity (HP:0004379)1.73407647
175Hyperparathyroidism (HP:0000843)1.72461726
176Pseudobulbar signs (HP:0002200)1.72228456
177Gout (HP:0001997)1.71770536
178Achilles tendon contracture (HP:0001771)1.70736371
179Obstructive lung disease (HP:0006536)1.70272549
180Chronic obstructive pulmonary disease (HP:0006510)1.70272549
181Vomiting (HP:0002013)1.70121450
182Vasculitis (HP:0002633)1.69047326
183Peritonitis (HP:0002586)1.65984869

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK5.52040580
2SIK15.48665216
3NME23.61726936
4TAOK23.54113302
5ERBB43.25184776
6TRIB33.15194754
7FGFR43.03464217
8PRPF4B2.99081629
9INSRR2.80114237
10PKN22.79317915
11FLT32.68832224
12ERN12.65431029
13MST1R2.56394046
14GRK72.54697633
15LATS12.53339129
16PIM22.52897525
17FRK2.29138883
18MATK2.14843570
19BMPR22.14375331
20TAOK32.12556415
21MET2.11677319
22CAMK1D2.10456683
23TAOK11.98207683
24RIPK41.97891600
25FGFR21.96278390
26MOS1.91865544
27NEK91.87507761
28IRAK41.78471698
29MAP3K111.74227509
30IRAK31.54001588
31LATS21.50445971
32BLK1.48231430
33MAP2K31.47164081
34CLK11.33968406
35MAP3K141.33828783
36MAPK111.32140797
37ARAF1.31999657
38STK38L1.31119181
39PBK1.31029671
40ICK1.30214239
41FGR1.29561364
42EPHB11.28758368
43FGFR31.28099267
44PRKAA21.24936487
45MAP3K131.17489515
46PTK61.16993229
47EPHA21.12717262
48MAP3K11.12696020
49ABL21.12614594
50BMX1.09456296
51EPHA31.08068069
52MAP3K51.05944417
53JAK11.03262861
54JAK21.02968980
55DDR21.02781728
56TYRO31.02237535
57GSK3A0.97284836
58PDGFRA0.96238011
59CAMK1G0.93856743
60STK30.93313242
61CDC42BPA0.92672180
62TBK10.89636112
63DYRK1B0.89291549
64MAP4K10.88682806
65EIF2AK30.86092730
66CDK60.84185268
67MAP3K30.83445671
68SGK4940.81641684
69SGK2230.81641684
70PRKAA10.81627116
71SGK30.81598302
72TYK20.81391107
73CSNK1G10.80784220
74CHUK0.79657337
75PINK10.78838763
76SGK20.76362461
77ERBB20.75854075
78RET0.75320749
79LMTK20.73916750
80CSK0.73862446
81RIPK10.73650100
82ZAP700.73487402
83SIK30.73090525
84DYRK30.72074628
85MAP2K40.70018217
86MAP3K20.69615135
87TGFBR20.69609007
88KSR10.68918427
89IRAK10.66944042
90BRAF0.64961730
91SCYL20.63994692
92MAP2K10.61737230
93FER0.60279578
94PRKACG0.59985429
95MAP3K80.58327813
96CSF1R0.57649682
97ADRBK20.57409853
98PRKCZ0.57226485
99PIK3CG0.56872523
100IGF1R0.56160520
101IRAK20.55989725
102EEF2K0.54942600
103CAMKK20.52677679
104MARK30.52481744
105PTK20.52440163
106STK100.50825892
107STK240.50296602
108PRKG20.49556601
109TESK10.48042441
110MAPK40.47445848
111PDGFRB0.47444137
112CDK140.47432967
113TXK0.46747641
114LYN0.46470912
115RAF10.46304310
116TRPM70.45870160
117JAK30.45692658
118TESK20.45260907
119IKBKB0.43680133
120CDK150.43276690
121IKBKE0.42994340
122MAP3K90.42842543
123EIF2AK20.42354157
124MAPK150.42250870
125SYK0.42129038
126RPS6KB10.41579832
127PAK40.40751682
128CSNK1A1L0.40705453
129FGFR10.40394348
130CDK11A0.39924646
131ABL10.39885247
132CDK180.39737644
133CDK40.39606739
134BCR0.38700599
135CSNK1G30.38654913
136NLK0.37564178
137PDPK10.37169087
138MTOR0.37163520
139PAK30.36367680
140PRKCH0.33986579
141ACVR1B0.33579819
142PKN10.32196668
143CSNK1G20.31811742
144MAP2K20.31317598
145RPS6KL10.30923961
146RPS6KC10.30923961
147PIM10.30800628
148MAPKAPK50.29222924
149EPHB20.27107718
150PDK20.25391684
151DAPK30.25250675
152EGFR0.24890433
153LCK0.24766857
154KSR20.22973649
155MAPK30.22965340
156HIPK20.22755460
157PDK10.22464430
158CDK120.22292347
159PRKCQ0.21628346
160HCK0.21378924
161DYRK20.20986025

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.97665851
2Nitrogen metabolism_Homo sapiens_hsa009103.63252846
3Other glycan degradation_Homo sapiens_hsa005113.31238787
4Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.17369775
5Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010403.07539093
6Toll-like receptor signaling pathway_Homo sapiens_hsa046202.95135155
7Steroid biosynthesis_Homo sapiens_hsa001002.64277409
8Arginine biosynthesis_Homo sapiens_hsa002202.57056659
9Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.55204986
10Fatty acid degradation_Homo sapiens_hsa000712.52925006
11Tryptophan metabolism_Homo sapiens_hsa003802.49793296
12NF-kappa B signaling pathway_Homo sapiens_hsa040642.48944448
13Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.47525211
14Rheumatoid arthritis_Homo sapiens_hsa053232.47429729
15Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.45367174
16Complement and coagulation cascades_Homo sapiens_hsa046102.39393501
17TNF signaling pathway_Homo sapiens_hsa046682.35250231
18Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.33804008
19Osteoclast differentiation_Homo sapiens_hsa043802.27333781
20Fatty acid metabolism_Homo sapiens_hsa012122.23630665
21NOD-like receptor signaling pathway_Homo sapiens_hsa046212.19777001
22Butanoate metabolism_Homo sapiens_hsa006502.19097304
23Pentose and glucuronate interconversions_Homo sapiens_hsa000402.18768869
24Propanoate metabolism_Homo sapiens_hsa006402.12498149
25Pertussis_Homo sapiens_hsa051332.12188878
26Peroxisome_Homo sapiens_hsa041462.08557647
27PPAR signaling pathway_Homo sapiens_hsa033202.06664191
28Leishmaniasis_Homo sapiens_hsa051401.99769022
29Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.95944707
30Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.94991545
31RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.89647746
32Salmonella infection_Homo sapiens_hsa051321.80966102
33Caffeine metabolism_Homo sapiens_hsa002321.79348922
34Chemical carcinogenesis_Homo sapiens_hsa052041.75720985
35Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.75508720
36Steroid hormone biosynthesis_Homo sapiens_hsa001401.75108388
37Histidine metabolism_Homo sapiens_hsa003401.74005563
38Selenocompound metabolism_Homo sapiens_hsa004501.71573037
39Sulfur metabolism_Homo sapiens_hsa009201.66676130
40Fatty acid elongation_Homo sapiens_hsa000621.63914059
41Tuberculosis_Homo sapiens_hsa051521.61773134
42African trypanosomiasis_Homo sapiens_hsa051431.60873236
43Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.59853684
44beta-Alanine metabolism_Homo sapiens_hsa004101.59209475
45Fatty acid biosynthesis_Homo sapiens_hsa000611.57978488
46Staphylococcus aureus infection_Homo sapiens_hsa051501.57857973
47Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.56290289
48Retinol metabolism_Homo sapiens_hsa008301.55790414
49Influenza A_Homo sapiens_hsa051641.55374049
50Drug metabolism - other enzymes_Homo sapiens_hsa009831.54373779
51Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.53287521
52Asthma_Homo sapiens_hsa053101.49932466
53Allograft rejection_Homo sapiens_hsa053301.39639563
54Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.38217171
55Fat digestion and absorption_Homo sapiens_hsa049751.37987150
56Tyrosine metabolism_Homo sapiens_hsa003501.35281773
57Pyruvate metabolism_Homo sapiens_hsa006201.32292119
58Toxoplasmosis_Homo sapiens_hsa051451.32191992
59Starch and sucrose metabolism_Homo sapiens_hsa005001.31898408
60Maturity onset diabetes of the young_Homo sapiens_hsa049501.31729987
61Bile secretion_Homo sapiens_hsa049761.31602637
622-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.29806547
63Phenylalanine metabolism_Homo sapiens_hsa003601.29670472
64Graft-versus-host disease_Homo sapiens_hsa053321.25780810
65Folate biosynthesis_Homo sapiens_hsa007901.24781167
66Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.22833728
67Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.22075363
68Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.16766807
69Intestinal immune network for IgA production_Homo sapiens_hsa046721.16053396
70Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.14568305
71Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.12678685
72B cell receptor signaling pathway_Homo sapiens_hsa046621.11588458
73Hepatitis B_Homo sapiens_hsa051611.09888364
74Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.08998596
75ABC transporters_Homo sapiens_hsa020101.06573445
76Shigellosis_Homo sapiens_hsa051311.04680762
77Measles_Homo sapiens_hsa051621.03950125
78Carbon metabolism_Homo sapiens_hsa012001.03665184
79Acute myeloid leukemia_Homo sapiens_hsa052211.03632502
80AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.03252712
81Biosynthesis of amino acids_Homo sapiens_hsa012301.03230324
82Herpes simplex infection_Homo sapiens_hsa051681.01856950
83Cysteine and methionine metabolism_Homo sapiens_hsa002701.00262507
84Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.94944171
85Phagosome_Homo sapiens_hsa041450.94322594
86Sphingolipid metabolism_Homo sapiens_hsa006000.92704848
87Sulfur relay system_Homo sapiens_hsa041220.89547975
88Vitamin B6 metabolism_Homo sapiens_hsa007500.89395610
89Arginine and proline metabolism_Homo sapiens_hsa003300.88436616
90Glycerolipid metabolism_Homo sapiens_hsa005610.88377226
91Apoptosis_Homo sapiens_hsa042100.88041329
92Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.87667670
93Jak-STAT signaling pathway_Homo sapiens_hsa046300.84610781
94One carbon pool by folate_Homo sapiens_hsa006700.84384841
95Amoebiasis_Homo sapiens_hsa051460.84374384
96Type II diabetes mellitus_Homo sapiens_hsa049300.82669964
97Vitamin digestion and absorption_Homo sapiens_hsa049770.81982246
98Hematopoietic cell lineage_Homo sapiens_hsa046400.81281270
99Type I diabetes mellitus_Homo sapiens_hsa049400.80636352
100Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.77824598
101Lysine degradation_Homo sapiens_hsa003100.75999160
102Antigen processing and presentation_Homo sapiens_hsa046120.73489346
103Autoimmune thyroid disease_Homo sapiens_hsa053200.73450194
104Chemokine signaling pathway_Homo sapiens_hsa040620.69081729
105VEGF signaling pathway_Homo sapiens_hsa043700.68443022
106Glutathione metabolism_Homo sapiens_hsa004800.65777111
107Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.64533173
108Vibrio cholerae infection_Homo sapiens_hsa051100.64064095
109Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.61971921
110Cyanoamino acid metabolism_Homo sapiens_hsa004600.61918849
111Chronic myeloid leukemia_Homo sapiens_hsa052200.59771365
112Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.58537016
113Epstein-Barr virus infection_Homo sapiens_hsa051690.56484402
114T cell receptor signaling pathway_Homo sapiens_hsa046600.56289807
115Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.55862084
116Collecting duct acid secretion_Homo sapiens_hsa049660.55006125
117Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.53766123
118Pentose phosphate pathway_Homo sapiens_hsa000300.53447142
119Sphingolipid signaling pathway_Homo sapiens_hsa040710.48470148
120Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.45295130
121Prion diseases_Homo sapiens_hsa050200.44887017
122Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.44615543
123HIF-1 signaling pathway_Homo sapiens_hsa040660.44539662
124Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.44170227
125Adipocytokine signaling pathway_Homo sapiens_hsa049200.42601792
126Neurotrophin signaling pathway_Homo sapiens_hsa047220.42188057
127Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.41572537
128Metabolic pathways_Homo sapiens_hsa011000.40974727
129Viral carcinogenesis_Homo sapiens_hsa052030.39257789
130Renal cell carcinoma_Homo sapiens_hsa052110.39199021
131Galactose metabolism_Homo sapiens_hsa000520.38302037
132Viral myocarditis_Homo sapiens_hsa054160.37674989
133Pancreatic cancer_Homo sapiens_hsa052120.37143460
134alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.36654801
135Insulin resistance_Homo sapiens_hsa049310.35863695
136Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.24813898
137AMPK signaling pathway_Homo sapiens_hsa041520.23853666
138Glycerophospholipid metabolism_Homo sapiens_hsa005640.22202815
139Linoleic acid metabolism_Homo sapiens_hsa005910.20298282
140Fructose and mannose metabolism_Homo sapiens_hsa000510.17274337
141Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.14785754
142Ovarian steroidogenesis_Homo sapiens_hsa049130.09803086
143Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.08830900
144Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.06532118
145Glucagon signaling pathway_Homo sapiens_hsa049220.04674475
146Central carbon metabolism in cancer_Homo sapiens_hsa052300.04164995
147Lysosome_Homo sapiens_hsa041420.03129210
148Insulin signaling pathway_Homo sapiens_hsa049100.01536723
149Longevity regulating pathway - multiple species_Homo sapiens_hsa04213-0.1531892
150Systemic lupus erythematosus_Homo sapiens_hsa05322-0.1505834
151Arachidonic acid metabolism_Homo sapiens_hsa00590-0.1383330
152Prolactin signaling pathway_Homo sapiens_hsa04917-0.1311176
153Longevity regulating pathway - mammal_Homo sapiens_hsa04211-0.1255184
154Renin-angiotensin system_Homo sapiens_hsa04614-0.1242539
155Bladder cancer_Homo sapiens_hsa05219-0.1092771
156Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.0859784
157Protein export_Homo sapiens_hsa03060-0.0676236
158Ether lipid metabolism_Homo sapiens_hsa00565-0.0620453
159Legionellosis_Homo sapiens_hsa05134-0.0567936
160Protein digestion and absorption_Homo sapiens_hsa04974-0.0565809
161Hepatitis C_Homo sapiens_hsa05160-0.0533905
162Malaria_Homo sapiens_hsa05144-0.0273341

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