INSIG2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is highly similar to the protein product encoded by gene INSIG1. Both INSIG1 protein and this protein are endoplasmic reticulum proteins that block the processing of sterol regulatory element binding proteins (SREBPs) by binding to SREBP cleavage-activating protein (SCAP), and thus prevent SCAP from escorting SREBPs to the Golgi. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.26664125
2L-phenylalanine catabolic process (GO:0006559)7.26664125
3erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.94300635
4L-phenylalanine metabolic process (GO:0006558)6.94300635
5aromatic amino acid family catabolic process (GO:0009074)6.60954498
6tryptophan catabolic process (GO:0006569)6.03251897
7indole-containing compound catabolic process (GO:0042436)6.03251897
8indolalkylamine catabolic process (GO:0046218)6.03251897
9triglyceride-rich lipoprotein particle remodeling (GO:0034370)6.01645763
10bile acid biosynthetic process (GO:0006699)5.77889756
11kynurenine metabolic process (GO:0070189)5.73869532
12tryptophan metabolic process (GO:0006568)5.68396724
13alpha-linolenic acid metabolic process (GO:0036109)5.49091372
14glyoxylate metabolic process (GO:0046487)5.47970038
154-hydroxyproline metabolic process (GO:0019471)5.41487104
16urea metabolic process (GO:0019627)5.29117430
17urea cycle (GO:0000050)5.29117430
18complement activation, alternative pathway (GO:0006957)5.26575106
19negative regulation of fibrinolysis (GO:0051918)5.22544354
20regulation of protein activation cascade (GO:2000257)5.20549637
21high-density lipoprotein particle remodeling (GO:0034375)5.19650850
22cysteine metabolic process (GO:0006534)5.14474554
23protein carboxylation (GO:0018214)5.12084959
24peptidyl-glutamic acid carboxylation (GO:0017187)5.12084959
25peptidyl-proline hydroxylation (GO:0019511)5.10952277
26regulation of fibrinolysis (GO:0051917)5.07544091
27sulfur amino acid catabolic process (GO:0000098)5.07149180
28fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.89936314
29bile acid metabolic process (GO:0008206)4.86888611
30regulation of complement activation (GO:0030449)4.86365954
31nitrogen cycle metabolic process (GO:0071941)4.84424094
32aromatic amino acid family metabolic process (GO:0009072)4.81963182
33regulation of triglyceride catabolic process (GO:0010896)4.76874029
34tyrosine metabolic process (GO:0006570)4.73990108
35serine family amino acid catabolic process (GO:0009071)4.67147915
36reverse cholesterol transport (GO:0043691)4.57629925
37cellular ketone body metabolic process (GO:0046950)4.54117260
38acylglycerol homeostasis (GO:0055090)4.54059514
39triglyceride homeostasis (GO:0070328)4.54059514
40homocysteine metabolic process (GO:0050667)4.52551273
41regulation of cholesterol esterification (GO:0010872)4.48190011
42plasma lipoprotein particle remodeling (GO:0034369)4.47677812
43protein-lipid complex remodeling (GO:0034368)4.47677812
44macromolecular complex remodeling (GO:0034367)4.47677812
45phospholipid efflux (GO:0033700)4.45295318
46positive regulation of mitochondrial fission (GO:0090141)4.44491995
47alpha-amino acid catabolic process (GO:1901606)4.42643940
48lysine catabolic process (GO:0006554)4.40447514
49lysine metabolic process (GO:0006553)4.40447514
50coenzyme catabolic process (GO:0009109)4.38792356
51amino-acid betaine metabolic process (GO:0006577)4.37143286
52indolalkylamine metabolic process (GO:0006586)4.31419250
53bile acid and bile salt transport (GO:0015721)4.31144530
54protein hydroxylation (GO:0018126)4.12702785
55intestinal cholesterol absorption (GO:0030299)4.12415112
56plasma lipoprotein particle clearance (GO:0034381)4.11863131
57negative regulation of cholesterol transport (GO:0032375)4.11517038
58negative regulation of sterol transport (GO:0032372)4.11517038
59glutamate metabolic process (GO:0006536)4.09914351
60cellular biogenic amine catabolic process (GO:0042402)4.09536696
61amine catabolic process (GO:0009310)4.09536696
62cellular amino acid catabolic process (GO:0009063)4.08198941
63cellular glucuronidation (GO:0052695)4.05166421
64mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)4.04369494
65positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021104.04369494
66ketone body metabolic process (GO:1902224)3.98886818
67cholesterol efflux (GO:0033344)3.98718910
68imidazole-containing compound metabolic process (GO:0052803)3.95690189
69dicarboxylic acid biosynthetic process (GO:0043650)3.95251002
70benzene-containing compound metabolic process (GO:0042537)3.94037479
71ethanol oxidation (GO:0006069)3.83244885
72fibrinolysis (GO:0042730)3.81886700
73cellular modified amino acid catabolic process (GO:0042219)3.81537721
74protein-lipid complex assembly (GO:0065005)3.78517358
75positive regulation of dendritic spine morphogenesis (GO:0061003)3.76955475
76arginine metabolic process (GO:0006525)3.76173727
77glycine metabolic process (GO:0006544)3.75155076
78aldehyde catabolic process (GO:0046185)3.74916196
79serine family amino acid metabolic process (GO:0009069)3.74513951
80cytolysis (GO:0019835)3.71104538
81carboxylic acid catabolic process (GO:0046395)3.70544022
82organic acid catabolic process (GO:0016054)3.70544022
83complement activation, classical pathway (GO:0006958)3.69275604
84cofactor catabolic process (GO:0051187)3.68295105
85low-density lipoprotein particle remodeling (GO:0034374)3.68165853
86negative regulation of lipase activity (GO:0060192)3.67580754
87plasma lipoprotein particle assembly (GO:0034377)3.66601254
88uronic acid metabolic process (GO:0006063)3.65818490
89glucuronate metabolic process (GO:0019585)3.65818490
90positive regulation of lipid catabolic process (GO:0050996)3.64078703
91monocarboxylic acid catabolic process (GO:0072329)3.63974672
92complement activation (GO:0006956)3.63322805
93opsonization (GO:0008228)3.62508070
94very-low-density lipoprotein particle assembly (GO:0034379)3.59398989
95acetyl-CoA metabolic process (GO:0006084)3.56789068
96protein activation cascade (GO:0072376)3.56197741
97phospholipid homeostasis (GO:0055091)3.56007052
98short-chain fatty acid metabolic process (GO:0046459)3.55441525
99COPII vesicle coating (GO:0048208)3.54565212
100positive regulation of lipoprotein lipase activity (GO:0051006)3.54524517
101positive regulation of triglyceride lipase activity (GO:0061365)3.54524517
102short-term memory (GO:0007614)3.53789283
103drug catabolic process (GO:0042737)3.52767257
104plasma lipoprotein particle organization (GO:0071827)3.52638172
105negative regulation of protein activation cascade (GO:2000258)3.51482170
106blood coagulation, intrinsic pathway (GO:0007597)3.50804267
107serine family amino acid biosynthetic process (GO:0009070)3.47487779
108cholesterol homeostasis (GO:0042632)3.45880375
109fructose metabolic process (GO:0006000)3.45164904
110fatty acid beta-oxidation (GO:0006635)3.44817172
111glycolytic process (GO:0006096)3.43968532
112fatty acid oxidation (GO:0019395)3.43058975
113sterol homeostasis (GO:0055092)3.40605122
114fatty acid catabolic process (GO:0009062)3.38603580
115neurofilament cytoskeleton organization (GO:0060052)3.36316306
116glucose 6-phosphate metabolic process (GO:0051156)3.35888557
117pyrimidine nucleobase catabolic process (GO:0006208)3.32076393
118C4-dicarboxylate transport (GO:0015740)3.31432019
119neurotransmitter-gated ion channel clustering (GO:0072578)3.28854689
120negative regulation of complement activation (GO:0045916)3.26647114
121regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)3.25621344
122L-ascorbic acid metabolic process (GO:0019852)3.15855256
123regulation of non-canonical Wnt signaling pathway (GO:2000050)3.15263581
124protein-lipid complex subunit organization (GO:0071825)3.14946467
125regulation of apoptotic cell clearance (GO:2000425)3.13412319
126regulation of plasminogen activation (GO:0010755)3.10670303
127positive regulation of heterotypic cell-cell adhesion (GO:0034116)3.09940586
128* cholesterol biosynthetic process (GO:0006695)3.00300440
129embryonic retina morphogenesis in camera-type eye (GO:0060059)2.88114942
130artery smooth muscle contraction (GO:0014824)2.87281194
131photoreceptor cell differentiation (GO:0046530)2.80751521
132eye photoreceptor cell differentiation (GO:0001754)2.80751521
133membrane budding (GO:0006900)2.80221654
134pyruvate metabolic process (GO:0006090)2.78749633
135nucleobase catabolic process (GO:0046113)2.76860577
136nephron epithelium morphogenesis (GO:0072088)2.76584564
137nephron tubule morphogenesis (GO:0072078)2.76584564
138regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.75711440
139presynaptic membrane assembly (GO:0097105)2.74162569
140* sterol biosynthetic process (GO:0016126)2.73604519
141water-soluble vitamin biosynthetic process (GO:0042364)2.70857578
142cholesterol transport (GO:0030301)2.65717235
143sterol transport (GO:0015918)2.65717235
144nonmotile primary cilium assembly (GO:0035058)2.64585455
145regulation of dendritic spine morphogenesis (GO:0061001)2.63686889
146vascular smooth muscle contraction (GO:0014829)2.63510378
147regulation of mitochondrial fission (GO:0090140)2.61931246
148positive regulation of blood coagulation (GO:0030194)2.61119549
149positive regulation of hemostasis (GO:1900048)2.61119549
150peptidyl-glutamic acid modification (GO:0018200)2.54273431
151regulation of bile acid biosynthetic process (GO:0070857)2.50475055
152retinal ganglion cell axon guidance (GO:0031290)2.47936772
153regulation of branching involved in ureteric bud morphogenesis (GO:0090189)2.47088525
154regulation of hexokinase activity (GO:1903299)2.46273758
155regulation of glucokinase activity (GO:0033131)2.46273758
156intestinal absorption (GO:0050892)2.45879807
157presynaptic membrane organization (GO:0097090)2.45488998
158positive regulation of extracellular matrix organization (GO:1903055)2.44459812
159cellular sodium ion homeostasis (GO:0006883)2.41859465
160acute-phase response (GO:0006953)2.40414598
161response to pheromone (GO:0019236)2.39695607
162protein localization to cilium (GO:0061512)2.38400885
163negative regulation of coagulation (GO:0050819)2.37549992
164positive regulation of transforming growth factor beta production (GO:0071636)2.35674349
165positive regulation of coagulation (GO:0050820)2.35375890
166maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.35329342

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* RXR_22158963_ChIP-Seq_LIVER_Mouse7.37147467
2* PPARA_22158963_ChIP-Seq_LIVER_Mouse6.27523938
3* EGR1_23403033_ChIP-Seq_LIVER_Mouse6.12249277
4* LXR_22158963_ChIP-Seq_LIVER_Mouse5.77442560
5FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.79172800
6* CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.26539478
7PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.22701914
8* HIF1A_21447827_ChIP-Seq_MCF-7_Human4.04236513
9* NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.83491059
10RBPJ_22232070_ChIP-Seq_NCS_Mouse3.65301960
11* CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.31879348
12HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.06782118
13POU3F2_20337985_ChIP-ChIP_501MEL_Human2.63231175
14ZFP57_27257070_Chip-Seq_ESCs_Mouse2.39934312
15ZNF274_21170338_ChIP-Seq_K562_Hela2.27048349
16CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.18974501
17IGF1R_20145208_ChIP-Seq_DFB_Human2.09569621
18* PCGF2_27294783_Chip-Seq_ESCs_Mouse2.04238021
19* ESR1_17901129_ChIP-ChIP_LIVER_Mouse10.3673255
20FLI1_27457419_Chip-Seq_LIVER_Mouse1.98841854
21SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.96444741
22ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.90394724
23SALL1_21062744_ChIP-ChIP_HESCs_Human1.86995454
24FUS_26573619_Chip-Seq_HEK293_Human1.83960734
25TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.82977988
26* TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.81594002
27HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.71430962
28OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.67675957
29WT1_19549856_ChIP-ChIP_CCG9911_Human1.60471886
30HTT_18923047_ChIP-ChIP_STHdh_Human1.59090822
31MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.57696972
32EWS_26573619_Chip-Seq_HEK293_Human1.56329360
33PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.55633019
34* FOXA2_19822575_ChIP-Seq_HepG2_Human1.51194124
35TCF4_18268006_ChIP-ChIP_LS174T_Human1.49244397
36SMAD3_21741376_ChIP-Seq_EPCs_Human1.49207880
37* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.47332770
38* PCGF2_27294783_Chip-Seq_NPCs_Mouse1.46256473
39CLOCK_20551151_ChIP-Seq_293T_Human1.44190615
40UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.43053365
41STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.42742308
42* NANOG_18555785_Chip-Seq_ESCs_Mouse1.42554843
43E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.40633459
44* SUZ12_27294783_Chip-Seq_NPCs_Mouse1.40443500
45* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.39981368
46ELK1_19687146_ChIP-ChIP_HELA_Human1.38467778
47* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.38415223
48* TP53_18474530_ChIP-ChIP_U2OS_Human1.38144764
49* TP53_16413492_ChIP-PET_HCT116_Human1.37810048
50GATA1_22025678_ChIP-Seq_K562_Human1.37102372
51SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.36718717
52TOP2B_26459242_ChIP-Seq_MCF-7_Human1.35590716
53STAT3_23295773_ChIP-Seq_U87_Human1.35423250
54PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.30036127
55* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.28702215
56AR_21572438_ChIP-Seq_LNCaP_Human1.28645512
57* RNF2_27304074_Chip-Seq_NSC_Mouse1.26004955
58NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.25684155
59EP300_21415370_ChIP-Seq_HL-1_Mouse1.25272607
60* HNF4A_19822575_ChIP-Seq_HepG2_Human1.25251693
61ER_23166858_ChIP-Seq_MCF-7_Human1.25176096
62CJUN_26792858_Chip-Seq_BT549_Human1.23960019
63TAF15_26573619_Chip-Seq_HEK293_Human1.22743221
64KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.22297795
65* RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.21617134
66* NFE2_27457419_Chip-Seq_LIVER_Mouse1.20359620
67* FOXM1_26456572_ChIP-Seq_MCF-7_Human1.19634086
68* NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.18351314
69* NRF2_20460467_ChIP-Seq_MEFs_Mouse1.18351314
70* KLF5_20875108_ChIP-Seq_MESCs_Mouse1.18301459
71* SUZ12_18555785_Chip-Seq_ESCs_Mouse1.15699353
72* P53_22387025_ChIP-Seq_ESCs_Mouse1.14234705
73TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.13984592
74* CMYC_18555785_Chip-Seq_ESCs_Mouse1.13708235
75TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.13580686
76* E2F1_18555785_Chip-Seq_ESCs_Mouse1.12273700
77* RUNX2_22187159_ChIP-Seq_PCA_Human1.10861776
78FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.10489922
79NR3C1_21868756_ChIP-Seq_MCF10A_Human1.08792715
80* EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.08602335
81STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.08140087
82KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.05857440
83PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.05020881
84CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04809344
85* STAT3_18555785_Chip-Seq_ESCs_Mouse1.04332317
86THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.04082700
87* P300_18555785_Chip-Seq_ESCs_Mouse1.03116187
88FLI1_21867929_ChIP-Seq_TH2_Mouse1.01851001
89TCF4_23295773_ChIP-Seq_U87_Human1.01385050
90PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.01305053
91* OCT4_18555785_Chip-Seq_ESCs_Mouse0.99666581
92SMAD_19615063_ChIP-ChIP_OVARY_Human0.99107750
93BCAT_22108803_ChIP-Seq_LS180_Human0.97740342
94RXRA_24833708_ChIP-Seq_LIVER_Mouse0.95471349
95BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.94693855
96PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.93276299
97IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.92779776
98ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.91034496
99Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.87704825
100PIAS1_25552417_ChIP-Seq_VCAP_Human0.86377994
101RARG_19884340_ChIP-ChIP_MEFs_Mouse0.83271861
102NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.82548251
103AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.81186899
104ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.80465509
105* SOX2_27498859_Chip-Seq_STOMACH_Mouse0.78784829
106ESR1_15608294_ChIP-ChIP_MCF-7_Human0.76774158
107ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.76379315
108* ESR2_21235772_ChIP-Seq_MCF-7_Human0.76039472
109GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.73859933
110AUTS2_25519132_ChIP-Seq_293T-REX_Human0.73019309
111VDR_22108803_ChIP-Seq_LS180_Human0.71701659
112ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.71376868
113* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.70022904
114ESR1_21235772_ChIP-Seq_MCF-7_Human0.69456181
115CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.68625921
116* GATA4_25053715_ChIP-Seq_YYC3_Human0.68423109
117ESR1_20079471_ChIP-ChIP_T-47D_Human0.67609741
118PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.65709255
119ERG_21242973_ChIP-ChIP_JURKAT_Human0.65137500
120RAD21_21589869_ChIP-Seq_MESCs_Mouse0.64630551
121* FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.62321459
122EGR1_19032775_ChIP-ChIP_M12_Human0.61290662
123* ZNF217_24962896_ChIP-Seq_MCF-7_Human0.60475281
124* SALL4_18804426_ChIP-ChIP_XEN_Mouse0.59902510
125SOX2_20726797_ChIP-Seq_SW620_Human0.59537314
126SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.59150043
127GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.59087029
128TRIM28_21343339_ChIP-Seq_HEK293_Human0.58968861
129* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.58036588
130GBX2_23144817_ChIP-Seq_PC3_Human0.57795687
131MYC_19915707_ChIP-ChIP_AK7_Human0.56432917
132KAP1_22055183_ChIP-Seq_ESCs_Mouse0.55684848
133* SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.55658757
134AR_25329375_ChIP-Seq_VCAP_Human0.55212707
135PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.54752233
136IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.54300716
137CBP_20019798_ChIP-Seq_JUKART_Human0.54300716
138CTBP2_25329375_ChIP-Seq_LNCAP_Human0.54289772
139* P300_19829295_ChIP-Seq_ESCs_Human0.54178256
140* FOXA1_25552417_ChIP-Seq_VCAP_Human0.53805479
141* CRX_20693478_ChIP-Seq_RETINA_Mouse0.53395738
142CEBPB_22108803_ChIP-Seq_LS180_Human0.53304087
143* TCF4_22108803_ChIP-Seq_LS180_Human0.52458780
144EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.51862593
145RARA_24833708_ChIP-Seq_LIVER_Mouse0.51724577
146STAT1_17558387_ChIP-Seq_HELA_Human0.51406029
147* TP63_23658742_ChIP-Seq_EP156T_Human0.51231154
148PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.50703979
149FOXH1_21741376_ChIP-Seq_EPCs_Human0.50581212
150CBP_21632823_ChIP-Seq_H3396_Human0.50432167
151* NCOR_22424771_ChIP-Seq_293T_Human0.50322914
152CDX2_19796622_ChIP-Seq_MESCs_Mouse0.50165728
153ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.50057453
154FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.50022701
155CDX2_22108803_ChIP-Seq_LS180_Human0.49973725
156AR_20517297_ChIP-Seq_VCAP_Human0.49831441
157CTBP1_25329375_ChIP-Seq_LNCAP_Human0.49824488
158* EZH2_27294783_Chip-Seq_NPCs_Mouse0.49774115
159CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.49709455
160ESET_19884257_ChIP-Seq_ESCs_Mouse0.49375884
161* SMAD4_21799915_ChIP-Seq_A2780_Human0.49263825
162PPAR_26484153_Chip-Seq_NCI-H1993_Human0.48203460
163FOXO3_23340844_ChIP-Seq_DLD1_Human0.46877714
164NANOG_19829295_ChIP-Seq_ESCs_Human0.46677085
165SOX2_19829295_ChIP-Seq_ESCs_Human0.46677085
166BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.46527772

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system8.27341863
2MP0005360_urolithiasis7.06468042
3MP0005085_abnormal_gallbladder_physiolo6.37007134
4MP0005365_abnormal_bile_salt6.16905126
5MP0003122_maternal_imprinting5.92553442
6MP0008875_abnormal_xenobiotic_pharmacok4.76554883
7MP0003806_abnormal_nucleotide_metabolis4.02837372
8MP0003252_abnormal_bile_duct3.93322229
9MP0010329_abnormal_lipoprotein_level3.55942876
10MP0003195_calcinosis3.19695204
11MP0005083_abnormal_biliary_tract2.93443574
12MP0009840_abnormal_foam_cell2.78417238
13MP0003121_genomic_imprinting2.78128172
14MP0004272_abnormal_basement_membrane2.75466535
15MP0006054_spinal_hemorrhage2.74235861
16MP0003950_abnormal_plasma_membrane2.65578145
17MP0005332_abnormal_amino_acid2.65432772
18MP0001984_abnormal_olfaction2.63630856
19MP0001666_abnormal_nutrient_absorption2.57727105
20MP0003191_abnormal_cellular_cholesterol2.26736539
21MP0002118_abnormal_lipid_homeostasis2.11411658
22MP0004019_abnormal_vitamin_homeostasis2.06407438
23MP0000609_abnormal_liver_physiology2.05916629
24MP0003880_abnormal_central_pattern1.98763339
25MP0002138_abnormal_hepatobiliary_system1.90861169
26MP0003868_abnormal_feces_composition1.90147767
27MP0005319_abnormal_enzyme/_coenzyme1.74479051
28MP0003123_paternal_imprinting1.73023242
29MP0001529_abnormal_vocalization1.63645553
30MP0008438_abnormal_cutaneous_collagen1.58603033
31MP0005584_abnormal_enzyme/coenzyme_acti1.57822382
32MP0009697_abnormal_copulation1.57588131
33MP0001764_abnormal_homeostasis1.51227310
34MP0003136_yellow_coat_color1.49169055
35MP0002938_white_spotting1.47782234
36MP0004270_analgesia1.42904158
37MP0002638_abnormal_pupillary_reflex1.40053211
38MP0002282_abnormal_trachea_morphology1.39145138
39MP0002233_abnormal_nose_morphology1.38862928
40MP0003890_abnormal_embryonic-extraembry1.35502249
41MP0000516_abnormal_urinary_system1.35493120
42MP0005367_renal/urinary_system_phenotyp1.35493120
43MP0005451_abnormal_body_composition1.32907942
44MP0005551_abnormal_eye_electrophysiolog1.26402506
45MP0003011_delayed_dark_adaptation1.26396272
46MP0005499_abnormal_olfactory_system1.24475104
47MP0005394_taste/olfaction_phenotype1.24475104
48MP0000372_irregular_coat_pigmentation1.24382262
49MP0002254_reproductive_system_inflammat1.24092624
50MP0003183_abnormal_peptide_metabolism1.22923376
51MP0003705_abnormal_hypodermis_morpholog1.21760865
52MP0000778_abnormal_nervous_system1.21557137
53MP0004142_abnormal_muscle_tone1.19529655
54MP0005257_abnormal_intraocular_pressure1.18619474
55MP0001915_intracranial_hemorrhage1.17184460
56MP0000604_amyloidosis1.14861162
57MP0009643_abnormal_urine_homeostasis1.14708283
58MP0005647_abnormal_sex_gland1.14314566
59MP0002837_dystrophic_cardiac_calcinosis1.13608185
60MP0004484_altered_response_of1.12730643
61MP0010386_abnormal_urinary_bladder1.10722543
62MP0002909_abnormal_adrenal_gland1.09628083
63MP0009780_abnormal_chondrocyte_physiolo1.08889147
64MP0003656_abnormal_erythrocyte_physiolo1.08760493
65MP0002876_abnormal_thyroid_physiology1.05228865
66MP0002557_abnormal_social/conspecific_i1.04422054
67MP0010368_abnormal_lymphatic_system1.03795034
68MP0003186_abnormal_redox_activity1.02392184
69MP0000598_abnormal_liver_morphology1.01496680
70MP0009046_muscle_twitch1.01452143
71MP0006072_abnormal_retinal_apoptosis1.00916134
72MP0001879_abnormal_lymphatic_vessel1.00058318
73MP0001286_abnormal_eye_development0.99740582
74MP0001324_abnormal_eye_pigmentation0.99697720
75MP0009764_decreased_sensitivity_to0.99398058
76MP0005410_abnormal_fertilization0.98397595
77MP0005636_abnormal_mineral_homeostasis0.98220499
78MP0000955_abnormal_spinal_cord0.92461471
79MP0003567_abnormal_fetal_cardiomyocyte0.90998751
80MP0000566_synostosis0.90857085
81MP0002078_abnormal_glucose_homeostasis0.88569596
82MP0002184_abnormal_innervation0.87997905
83MP0003221_abnormal_cardiomyocyte_apopto0.87463477
84MP0009763_increased_sensitivity_to0.86056624
85MP0005253_abnormal_eye_physiology0.85906407
86MP0009642_abnormal_blood_homeostasis0.84356001
87MP0001486_abnormal_startle_reflex0.84014962
88MP0004130_abnormal_muscle_cell0.83655818
89MP0008789_abnormal_olfactory_epithelium0.83472288
90MP0006036_abnormal_mitochondrial_physio0.82823266
91MP0005535_abnormal_body_temperature0.82625080
92MP0003942_abnormal_urinary_system0.82517969
93MP0005408_hypopigmentation0.82172430
94MP0004859_abnormal_synaptic_plasticity0.80610545
95MP0003329_amyloid_beta_deposits0.80267108
96MP0002822_catalepsy0.79013974
97MP0008469_abnormal_protein_level0.78490409
98MP0005084_abnormal_gallbladder_morpholo0.78331195
99MP0002971_abnormal_brown_adipose0.78160636
100MP0002132_abnormal_respiratory_system0.77947470
101MP0008995_early_reproductive_senescence0.77310119
102MP0001299_abnormal_eye_distance/0.76659652
103MP0003315_abnormal_perineum_morphology0.76499508
104MP0005670_abnormal_white_adipose0.74739334
105MP0006035_abnormal_mitochondrial_morpho0.74287524
106MP0002102_abnormal_ear_morphology0.74185508
107MP0004742_abnormal_vestibular_system0.73300289
108MP0005376_homeostasis/metabolism_phenot0.73222132
109MP0001270_distended_abdomen0.72293401
110MP0005195_abnormal_posterior_eye0.71844995
111MP0005334_abnormal_fat_pad0.69917411
112MP0002067_abnormal_sensory_capabilities0.69010940
113MP0001293_anophthalmia0.68757454
114MP0000534_abnormal_ureter_morphology0.67400989
115MP0005386_behavior/neurological_phenoty0.67308074
116MP0004924_abnormal_behavior0.67308074
117MP0002736_abnormal_nociception_after0.67109500
118MP0005187_abnormal_penis_morphology0.66388789
119MP0002796_impaired_skin_barrier0.66265924
120MP0003937_abnormal_limbs/digits/tail_de0.65798715
121MP0005448_abnormal_energy_balance0.65631659
122MP0005167_abnormal_blood-brain_barrier0.64895326
123MP0005220_abnormal_exocrine_pancreas0.64565710
124MP0003690_abnormal_glial_cell0.64442797
125MP0003633_abnormal_nervous_system0.64044592
126MP0003755_abnormal_palate_morphology0.63165121
127MP0002734_abnormal_mechanical_nocicepti0.62356395
128MP0002697_abnormal_eye_size0.61798071
129MP0000639_abnormal_adrenal_gland0.59765759
130MP0009765_abnormal_xenobiotic_induced0.59736886
131MP0001756_abnormal_urination0.58019632
132MP0005266_abnormal_metabolism0.57181052
133MP0004782_abnormal_surfactant_physiolog0.54487047
134MP0001661_extended_life_span0.53193602
135MP0000579_abnormal_nail_morphology0.53039757
136MP0004381_abnormal_hair_follicle0.51446022
137MP0000427_abnormal_hair_cycle0.49592711
138MP0005395_other_phenotype0.47876089
139MP0009384_cardiac_valve_regurgitation0.47742194
140MP0002060_abnormal_skin_morphology0.47282168
141MP0002168_other_aberrant_phenotype0.45898838
142MP0005666_abnormal_adipose_tissue0.45647079
143MP0003953_abnormal_hormone_level0.45341721
144MP0008874_decreased_physiological_sensi0.44254733
145MP0000230_abnormal_systemic_arterial0.42560947
146MP0003724_increased_susceptibility_to0.41420603
147MP0004043_abnormal_pH_regulation0.41133074
148MP0003638_abnormal_response/metabolism_0.40545764
149MP0009053_abnormal_anal_canal0.40538629
150MP0003075_altered_response_to0.40039567
151MP0005166_decreased_susceptibility_to0.39913870
152MP0010234_abnormal_vibrissa_follicle0.38232847
153MP0005248_abnormal_Harderian_gland0.37062706
154MP0002136_abnormal_kidney_physiology0.36775727
155MP0002090_abnormal_vision0.33407304
156MP0002928_abnormal_bile_duct0.33279510
157MP0004883_abnormal_blood_vessel0.33065919
158MP0008873_increased_physiological_sensi0.31560624
159MP0000249_abnormal_blood_vessel0.31175048
160MP0005595_abnormal_vascular_smooth0.30994478
161MP0006276_abnormal_autonomic_nervous0.30672832
162MP0001243_abnormal_dermal_layer0.29934030
163MP0005164_abnormal_response_to0.29219915
164MP0002295_abnormal_pulmonary_circulatio0.28438818
165MP0005464_abnormal_platelet_physiology0.28324506
166MP0001881_abnormal_mammary_gland0.28280582
167MP0001944_abnormal_pancreas_morphology0.28211684
168MP0005646_abnormal_pituitary_gland0.28028352
169MP0002970_abnormal_white_adipose0.27038554
170MP0004185_abnormal_adipocyte_glucose0.26969779

Predicted human phenotypes

RankGene SetZ-score
1Intrahepatic cholestasis (HP:0001406)7.03237439
2Abnormality of aromatic amino acid family metabolism (HP:0004338)6.98359812
3Deep venous thrombosis (HP:0002625)6.85409885
4Prolonged partial thromboplastin time (HP:0003645)6.49365377
5Abnormality of monocarboxylic acid metabolism (HP:0010996)6.16299311
6Hypobetalipoproteinemia (HP:0003563)6.06667276
7Xanthomatosis (HP:0000991)6.02840330
8Abnormality of glycolysis (HP:0004366)5.58024149
9Hyperlipoproteinemia (HP:0010980)5.51751789
10Increased serum pyruvate (HP:0003542)5.38263613
11Complement deficiency (HP:0004431)5.36995400
12Hypolipoproteinemia (HP:0010981)4.55757087
13Hyperammonemia (HP:0001987)4.51894416
14Epidermoid cyst (HP:0200040)4.51427773
15Conjugated hyperbilirubinemia (HP:0002908)4.40906609
16Joint hemorrhage (HP:0005261)4.36025492
17Abnormality of the common coagulation pathway (HP:0010990)4.34703111
18Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.25424822
19Ketosis (HP:0001946)4.15546400
20Hypoglycemic coma (HP:0001325)4.10774660
21Fat malabsorption (HP:0002630)4.06329957
22Hyperglycinemia (HP:0002154)4.02424938
23Hypoalphalipoproteinemia (HP:0003233)4.00563815
24Abnormality of the intrinsic pathway (HP:0010989)3.95411236
25Abnormality of sulfur amino acid metabolism (HP:0004339)3.91393728
26Abnormality of methionine metabolism (HP:0010901)3.89887117
27Abnormality of complement system (HP:0005339)3.84436702
28Abnormality of aspartate family amino acid metabolism (HP:0010899)3.82384131
29Abnormality of glutamine family amino acid metabolism (HP:0010902)3.80934800
30Small epiphyses (HP:0010585)3.71292319
31Abnormal tarsal ossification (HP:0008369)3.64068988
32Hyperglycinuria (HP:0003108)3.45152258
33Abnormality of serine family amino acid metabolism (HP:0010894)3.43054173
34Abnormality of glycine metabolism (HP:0010895)3.43054173
35Abnormality of fatty-acid metabolism (HP:0004359)3.30813606
36Ketoacidosis (HP:0001993)3.24560435
37Hyperbilirubinemia (HP:0002904)3.23231828
38Hypercholesterolemia (HP:0003124)3.22917137
39Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.22886681
40Abnormality of pyrimidine metabolism (HP:0004353)3.22243109
41Hypothermia (HP:0002045)3.18581967
42Exercise-induced muscle cramps (HP:0003710)3.14892069
43Spontaneous abortion (HP:0005268)3.09045735
44Systemic lupus erythematosus (HP:0002725)3.05356464
45Steatorrhea (HP:0002570)3.03816445
46Hypoglycemic seizures (HP:0002173)3.02948669
47Skin nodule (HP:0200036)2.90002351
48Broad alveolar ridges (HP:0000187)2.88518682
49Hepatocellular carcinoma (HP:0001402)2.87585880
50Abnormality of nucleobase metabolism (HP:0010932)2.85295165
51Epiphyseal dysplasia (HP:0002656)2.81279850
52Myocardial infarction (HP:0001658)2.80539688
53Delayed CNS myelination (HP:0002188)2.79973110
54Abnormality of serum amino acid levels (HP:0003112)2.77944397
55Vascular calcification (HP:0004934)2.74773696
56Medial flaring of the eyebrow (HP:0010747)2.73911014
57Abnormality of carpal bone ossification (HP:0006257)2.69390663
58Metabolic acidosis (HP:0001942)2.67572222
59Abnormality of purine metabolism (HP:0004352)2.66821193
60Action tremor (HP:0002345)2.66468825
61Congenital primary aphakia (HP:0007707)2.61926568
62Gait imbalance (HP:0002141)2.61812254
63Gout (HP:0001997)2.61348133
64Abnormal gallbladder morphology (HP:0012437)2.59468983
65Abnormal gallbladder physiology (HP:0012438)2.56113559
66Cholecystitis (HP:0001082)2.56113559
67Papillary thyroid carcinoma (HP:0002895)2.54083278
68Cholelithiasis (HP:0001081)2.53763993
69Pancreatic islet-cell hyperplasia (HP:0004510)2.53738670
70Cardiovascular calcification (HP:0011915)2.47956949
71Lethargy (HP:0001254)2.47710055
72Irregular epiphyses (HP:0010582)2.46623297
73Mitral stenosis (HP:0001718)2.45665780
74Abnormality of the wing of the ilium (HP:0011867)2.45154362
75Dicarboxylic aciduria (HP:0003215)2.44553435
76Abnormality of dicarboxylic acid metabolism (HP:0010995)2.44553435
77Nephrogenic diabetes insipidus (HP:0009806)2.44194457
78True hermaphroditism (HP:0010459)2.42861753
79Supernumerary spleens (HP:0009799)2.42686388
80Hyperinsulinemic hypoglycemia (HP:0000825)2.42076590
81Cerebral edema (HP:0002181)2.41680014
82Hypochromic microcytic anemia (HP:0004840)2.39635499
83Vaginal atresia (HP:0000148)2.39523248
84Genital tract atresia (HP:0001827)2.38040877
85Enlarged kidneys (HP:0000105)2.32428305
86Arterial tortuosity (HP:0005116)2.30950991
87Arthropathy (HP:0003040)2.28397505
88Sensorimotor neuropathy (HP:0007141)2.24102311
89Acanthocytosis (HP:0001927)2.23728448
90Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.23495403
91Abnormal hand bone ossification (HP:0010660)2.22071260
92Irritability (HP:0000737)2.21145185
93Neonatal onset (HP:0003623)2.20622839
94Postural tremor (HP:0002174)2.19342419
95Amyloidosis (HP:0011034)2.17173673
96Hepatoblastoma (HP:0002884)2.17069919
97Recurrent gram-negative bacterial infections (HP:0005420)2.16621475
98Broad palm (HP:0001169)2.16221934
99Glomerulonephritis (HP:0000099)2.16069474
100Hyperventilation (HP:0002883)2.12782398
101Late onset (HP:0003584)2.12407681
102Spastic diplegia (HP:0001264)2.12116377
103Hypoplasia of the capital femoral epiphysis (HP:0003090)2.12012687
104Malnutrition (HP:0004395)2.11906895
105Abnormality of the gallbladder (HP:0005264)2.09556607
106Abnormal foot bone ossification (HP:0010675)2.09373474
107Symptomatic seizures (HP:0011145)2.09226656
108Proximal tubulopathy (HP:0000114)2.08929675
109Hypoplastic pelvis (HP:0008839)2.08275875
110Vomiting (HP:0002013)2.07895909
111Abnormality of the pubic bones (HP:0003172)2.07862967
112Pancreatitis (HP:0001733)2.07685853
113Brushfield spots (HP:0001088)2.06939185
114Gingival bleeding (HP:0000225)2.06872220
115Abnormality of proline metabolism (HP:0010907)2.06501162
116Vascular tortuosity (HP:0004948)2.04346778
117Atonic seizures (HP:0010819)2.02805098
118Generalized aminoaciduria (HP:0002909)2.02700633
119Rickets (HP:0002748)2.01907634
120Abnormality of endocrine pancreas physiology (HP:0012093)2.01819739
121Abnormality of the pancreatic islet cells (HP:0006476)2.01819739
122Opisthotonus (HP:0002179)1.99112382
123Esophageal varix (HP:0002040)1.97778732
124Hyperglycemia (HP:0003074)1.97141623
125Back pain (HP:0003418)1.95473778
126Exotropia (HP:0000577)1.95472072
127Neuroendocrine neoplasm (HP:0100634)1.94120659
128Abnormality of the nasal septum (HP:0000419)1.93515320
129Broad foot (HP:0001769)1.93402323
130Metaphyseal irregularity (HP:0003025)1.91666445
131Focal motor seizures (HP:0011153)1.91169786
132Neonatal short-limb short stature (HP:0008921)1.90312503
133Fair hair (HP:0002286)1.90101787
134Thrombophlebitis (HP:0004418)1.90005116
135Renal cortical cysts (HP:0000803)1.89604242
136Hypophosphatemic rickets (HP:0004912)1.89517217
137Osteomalacia (HP:0002749)1.89004385
138Menorrhagia (HP:0000132)1.88817693
139Abnormality of urine glucose concentration (HP:0011016)1.87091547
140Glycosuria (HP:0003076)1.87091547
141Poor coordination (HP:0002370)1.85017524
142Thyroid carcinoma (HP:0002890)1.82975018
143Scrotal hypoplasia (HP:0000046)1.82768911
144Disproportionate short-trunk short stature (HP:0003521)1.81057866
145Status epilepticus (HP:0002133)1.81002268
146Decreased muscle mass (HP:0003199)1.80484952
147Hyperphosphaturia (HP:0003109)1.79671988
148Death in childhood (HP:0003819)1.77809913
149Pheochromocytoma (HP:0002666)1.76831218
150Bifid tongue (HP:0010297)1.76129498
151Anophthalmia (HP:0000528)1.76055735
152Abnormality of transition element cation homeostasis (HP:0011030)1.76005640
153Increased purine levels (HP:0004368)1.75559265
154Hyperuricemia (HP:0002149)1.75559265
155Febrile seizures (HP:0002373)1.74501441
156Hydroxyprolinuria (HP:0003080)1.74138315
157Barrel-shaped chest (HP:0001552)1.72743631
158Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.70731809
159Absent epiphyses (HP:0010577)1.70731809
160Abnormal ossification of hand bones (HP:0005921)1.68595878
161Aplasia/Hypoplasia of the tongue (HP:0010295)1.68006055
162Increased hepatocellular lipid droplets (HP:0006565)1.67004983
163Methylmalonic acidemia (HP:0002912)1.63831745
164Alacrima (HP:0000522)1.63049559
165Postaxial hand polydactyly (HP:0001162)1.62399180
166Hemiparesis (HP:0001269)1.59341986
167Pancreatic cysts (HP:0001737)1.57769887

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK5.92668050
2INSRR4.09953205
3FGFR43.68569621
4MAP4K23.48712586
5ERN13.46165086
6TNIK3.45094631
7SIK13.25586755
8EIF2AK32.98509440
9ERBB42.78737039
10TRIM282.64481797
11MAP2K42.57171455
12NEK12.56565896
13TAOK32.30536025
14MAPK112.24340964
15MST1R2.22331326
16MAP3K122.19505067
17PIK3CG2.18094287
18WNK42.13902970
19DAPK22.09427968
20ERBB32.07741452
21TYK22.07160676
22FGFR12.06706936
23STK391.94739606
24EPHA31.84070083
25FRK1.81396759
26WNK31.81105693
27MST41.61743370
28FLT31.61137018
29NEK91.59045738
30MAP3K91.58215439
31PLK21.54036807
32MARK11.53022545
33EIF2AK11.50599609
34PKN21.48171456
35PINK11.46310836
36LATS11.43499670
37STK241.41689476
38ARAF1.39887779
39NTRK21.30430124
40BMPR1B1.25380888
41FGFR21.19935938
42MAP3K21.19311529
43FER1.19108578
44EPHA41.14357312
45PDK31.11957114
46PDK41.11957114
47DYRK1B1.11501563
48SGK31.10438042
49MAP3K31.09972106
50MOS1.07630150
51MAP3K71.05404757
52SGK21.02268080
53DDR21.01684298
54PLK31.00180359
55MAP2K30.99493941
56JAK10.96280822
57JAK20.94799815
58ABL20.94238106
59YES10.93899186
60MAPK130.92368004
61PDK20.91155544
62STK38L0.90918733
63PTK60.89135036
64BRSK20.89053772
65CAMK2G0.87576941
66MAP3K140.87305134
67MINK10.87133965
68NTRK10.87012227
69SIK30.85429708
70OBSCN0.85022318
71PRKAA20.84235395
72RPS6KA40.83851696
73MAPK120.83173011
74NUAK10.82234884
75PRKCZ0.81357639
76SGK2230.79695855
77SGK4940.79695855
78IRAK30.79553165
79MAP2K70.77478990
80TRIB30.76840641
81MET0.75876803
82PRKACG0.75754939
83PAK30.74565285
84MAP2K10.74525286
85CASK0.71870287
86STK160.71011145
87ERBB20.68718357
88STK30.68667749
89MAPK150.68269092
90PRKCG0.65244991
91MAPK40.62303757
92MAP3K40.61344161
93PRKCQ0.60738194
94TBK10.60701908
95PIK3CA0.59717126
96KDR0.57423949
97MAPK70.56694626
98NLK0.56148499
99EPHB20.55880079
100FGFR30.55230416
101MYLK0.55102327
102MKNK20.54956175
103PDPK10.54647824
104GSK3A0.53036542
105AKT30.52167339
106WNK10.52119557
107MAP3K10.52057629
108KSR10.50799416
109CDK50.50792993
110TGFBR20.50187395
111LIMK10.50173067
112PRKAA10.49718600
113SRPK10.49665970
114TIE10.49556589
115ROCK20.49525499
116IGF1R0.49407627
117MAP2K60.48556068
118CSNK1G20.47885710
119CSNK1G10.47507259
120SIK20.47283588
121PTK20.47121350
122FGR0.46076727
123BRD40.45695562
124DYRK1A0.43951640
125MKNK10.42455298
126NEK20.42167894
127RET0.41512475
128PRKCH0.41004632
129GRK10.40450009
130CAMKK20.39476436
131VRK10.39413547
132OXSR10.38199440
133PKN10.37989555
134PRKG10.37429138
135CAMK1D0.36517726
136CSNK1G30.36311837
137CSNK1E0.35586556
138CAMK2A0.35331629
139LATS20.34981215
140TYRO30.34415740
141PRKCA0.33384414
142EPHB10.33038478
143CAMK40.32630716
144NTRK30.32169287
145DYRK20.32143131
146TAF10.31916491
147PRKCE0.31797366
148PRKACA0.31623908
149CDK180.31178663
150GRK60.30894963
151PDK10.30437677
152PTK2B0.29875479
153IRAK10.29686552
154PDGFRA0.29588904
155CDK60.29280695
156BCR0.28161214
157CSNK1A1L0.26416328

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.50567635
2Protein export_Homo sapiens_hsa030603.83288042
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.46635165
4Nitrogen metabolism_Homo sapiens_hsa009103.35122576
5Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.11487686
6Arginine biosynthesis_Homo sapiens_hsa002202.97593086
7Complement and coagulation cascades_Homo sapiens_hsa046102.71486957
8Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.69817120
9Tryptophan metabolism_Homo sapiens_hsa003802.68750370
10Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.55436837
11Fatty acid degradation_Homo sapiens_hsa000712.53686354
12Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.43985626
13Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.36132299
14Butanoate metabolism_Homo sapiens_hsa006502.24510284
15Peroxisome_Homo sapiens_hsa041462.17183619
16Propanoate metabolism_Homo sapiens_hsa006402.08456459
17Pentose and glucuronate interconversions_Homo sapiens_hsa000402.07128356
18Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.06750861
19Fatty acid metabolism_Homo sapiens_hsa012121.91046336
20PPAR signaling pathway_Homo sapiens_hsa033201.89953479
21Retinol metabolism_Homo sapiens_hsa008301.89321721
22Histidine metabolism_Homo sapiens_hsa003401.87195363
23Chemical carcinogenesis_Homo sapiens_hsa052041.85045631
24Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.83037497
25Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.77006111
26Steroid hormone biosynthesis_Homo sapiens_hsa001401.76216145
27beta-Alanine metabolism_Homo sapiens_hsa004101.76048941
28Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.74662289
29Phenylalanine metabolism_Homo sapiens_hsa003601.70312121
30Staphylococcus aureus infection_Homo sapiens_hsa051501.66492037
31Drug metabolism - other enzymes_Homo sapiens_hsa009831.60386865
32Tyrosine metabolism_Homo sapiens_hsa003501.55563842
332-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.55235791
34Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.54944859
35Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.53686171
36Fatty acid elongation_Homo sapiens_hsa000621.50949683
37Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.49397819
38Pyruvate metabolism_Homo sapiens_hsa006201.46543202
39Sulfur metabolism_Homo sapiens_hsa009201.46371677
40Bile secretion_Homo sapiens_hsa049761.43694784
41Caffeine metabolism_Homo sapiens_hsa002321.42172931
42Selenocompound metabolism_Homo sapiens_hsa004501.36641848
43Starch and sucrose metabolism_Homo sapiens_hsa005001.33607547
44Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.23104897
45Cysteine and methionine metabolism_Homo sapiens_hsa002701.22085662
46Fat digestion and absorption_Homo sapiens_hsa049751.19640218
47Folate biosynthesis_Homo sapiens_hsa007901.16647874
48Maturity onset diabetes of the young_Homo sapiens_hsa049501.15300986
49ABC transporters_Homo sapiens_hsa020101.15189958
50Carbon metabolism_Homo sapiens_hsa012001.14288606
51Mineral absorption_Homo sapiens_hsa049781.10791540
52Biosynthesis of amino acids_Homo sapiens_hsa012301.09194511
53Proteasome_Homo sapiens_hsa030500.99677070
54Phototransduction_Homo sapiens_hsa047440.93186136
55Steroid biosynthesis_Homo sapiens_hsa001000.93070517
56HIF-1 signaling pathway_Homo sapiens_hsa040660.89799486
57Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.87864849
58Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.86646956
59Arginine and proline metabolism_Homo sapiens_hsa003300.86389604
60Cyanoamino acid metabolism_Homo sapiens_hsa004600.82203322
61Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.81880065
62Vitamin digestion and absorption_Homo sapiens_hsa049770.80782078
63Vitamin B6 metabolism_Homo sapiens_hsa007500.80485909
64Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.77857509
65Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.74824702
66Sulfur relay system_Homo sapiens_hsa041220.71699590
67Lysine degradation_Homo sapiens_hsa003100.69774726
68Glycerolipid metabolism_Homo sapiens_hsa005610.69242876
69Sphingolipid metabolism_Homo sapiens_hsa006000.68118296
70Nicotine addiction_Homo sapiens_hsa050330.62663866
71Fatty acid biosynthesis_Homo sapiens_hsa000610.60652614
72RNA degradation_Homo sapiens_hsa030180.59119430
73Glutathione metabolism_Homo sapiens_hsa004800.58154866
74Basal transcription factors_Homo sapiens_hsa030220.56443553
75Protein digestion and absorption_Homo sapiens_hsa049740.54533397
76GABAergic synapse_Homo sapiens_hsa047270.48438191
77Parkinsons disease_Homo sapiens_hsa050120.47037053
78N-Glycan biosynthesis_Homo sapiens_hsa005100.46651450
79Metabolic pathways_Homo sapiens_hsa011000.46419835
80Prion diseases_Homo sapiens_hsa050200.45340815
81Vibrio cholerae infection_Homo sapiens_hsa051100.44362017
82Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.42306537
83Pentose phosphate pathway_Homo sapiens_hsa000300.41990234
84Ether lipid metabolism_Homo sapiens_hsa005650.41084509
85Glutamatergic synapse_Homo sapiens_hsa047240.37759790
86Fructose and mannose metabolism_Homo sapiens_hsa000510.32222349
87Galactose metabolism_Homo sapiens_hsa000520.30554809
88Hedgehog signaling pathway_Homo sapiens_hsa043400.30171829
89One carbon pool by folate_Homo sapiens_hsa006700.29845717
90alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.27605004
91ECM-receptor interaction_Homo sapiens_hsa045120.26256934
92Adipocytokine signaling pathway_Homo sapiens_hsa049200.24215091
93Insulin resistance_Homo sapiens_hsa049310.24186333
94TGF-beta signaling pathway_Homo sapiens_hsa043500.24180504
95Axon guidance_Homo sapiens_hsa043600.23853783
96Glucagon signaling pathway_Homo sapiens_hsa049220.22772619
97Alzheimers disease_Homo sapiens_hsa050100.21843211
98Dopaminergic synapse_Homo sapiens_hsa047280.21839042
99Linoleic acid metabolism_Homo sapiens_hsa005910.18651738
100Glycerophospholipid metabolism_Homo sapiens_hsa005640.16279531
101Taste transduction_Homo sapiens_hsa047420.14850456
102Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.13832274
103Adherens junction_Homo sapiens_hsa045200.13409421
104Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.12432370
105Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.11738490
106Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.08256513
107Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.01882486
108AMPK signaling pathway_Homo sapiens_hsa041520.01700241
109Longevity regulating pathway - multiple species_Homo sapiens_hsa04213-0.2120208
110Oxidative phosphorylation_Homo sapiens_hsa00190-0.2025298
111Amoebiasis_Homo sapiens_hsa05146-0.2009647
112Lysosome_Homo sapiens_hsa04142-0.1956704
113Hepatitis C_Homo sapiens_hsa05160-0.1866566
114Type II diabetes mellitus_Homo sapiens_hsa04930-0.1838343
115Circadian rhythm_Homo sapiens_hsa04710-0.1777673
116Renin-angiotensin system_Homo sapiens_hsa04614-0.1566616
117Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.1470104
118African trypanosomiasis_Homo sapiens_hsa05143-0.1375092
119Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.1325289
120Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141-0.1325147
121Arachidonic acid metabolism_Homo sapiens_hsa00590-0.1263336
122Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604-0.1157387
123Regulation of autophagy_Homo sapiens_hsa04140-0.1148231
124Thyroid hormone synthesis_Homo sapiens_hsa04918-0.0838714
125Ovarian steroidogenesis_Homo sapiens_hsa04913-0.0784832
126Insulin signaling pathway_Homo sapiens_hsa04910-0.0331600
127Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.0185741

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