INSL4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: INSL4 encodes the insulin-like 4 protein, a member of the insulin superfamily. INSL4 encodes a precursor that undergoes post-translational cleavage to produce 3 polypeptide chains, A-C, that form tertiary structures composed of either all three chains, or just the A and B chains. Expression of INSL4 products occurs within the early placental cytotrophoblast and syncytiotrophoblast. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ncRNA 3-end processing (GO:0043628)5.95812976
2neuronal action potential propagation (GO:0019227)5.65427751
3polyketide metabolic process (GO:0030638)5.03784996
4doxorubicin metabolic process (GO:0044598)5.03784996
5daunorubicin metabolic process (GO:0044597)5.03784996
6folic acid metabolic process (GO:0046655)4.69930317
7gamma-aminobutyric acid transport (GO:0015812)4.68937841
8aminoglycoside antibiotic metabolic process (GO:0030647)4.48441119
9positive regulation of mitochondrial fission (GO:0090141)4.38050868
10cellular ketone body metabolic process (GO:0046950)4.13853172
11ubiquinone biosynthetic process (GO:0006744)4.08093236
12DNA replication checkpoint (GO:0000076)3.95055027
13replication fork processing (GO:0031297)3.94928734
14protein K6-linked ubiquitination (GO:0085020)3.70842102
15pyrimidine dimer repair (GO:0006290)3.68909319
16rRNA methylation (GO:0031167)3.68383685
17ketone body metabolic process (GO:1902224)3.67415772
18ubiquinone metabolic process (GO:0006743)3.62110746
19pseudouridine synthesis (GO:0001522)3.61081858
20response to nitrosative stress (GO:0051409)3.59291303
21mitochondrial fission (GO:0000266)3.57499383
22L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.55840056
23quinone metabolic process (GO:1901661)3.52701389
24homocysteine metabolic process (GO:0050667)3.51780279
25folic acid transport (GO:0015884)3.49055532
26respiratory chain complex IV assembly (GO:0008535)3.48298099
27rRNA modification (GO:0000154)3.36299977
28cornea development in camera-type eye (GO:0061303)3.32454089
29quinone biosynthetic process (GO:1901663)3.31558465
30cytochrome complex assembly (GO:0017004)3.29281006
31protein-cofactor linkage (GO:0018065)3.27518968
32water-soluble vitamin biosynthetic process (GO:0042364)3.24621149
33base-excision repair, AP site formation (GO:0006285)3.19779916
34epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.16578809
35organelle disassembly (GO:1903008)3.12078176
36maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.10990980
37ribosomal small subunit biogenesis (GO:0042274)3.10602264
38GPI anchor metabolic process (GO:0006505)3.02755576
39regulation of mitochondrial fission (GO:0090140)3.00734383
40positive regulation of inositol phosphate biosynthetic process (GO:0060732)2.98947745
41negative regulation of complement activation (GO:0045916)2.98747708
42glycoside metabolic process (GO:0016137)2.93075892
43DNA synthesis involved in DNA repair (GO:0000731)2.92131205
44DNA double-strand break processing (GO:0000729)2.91906425
45amino acid salvage (GO:0043102)2.91654359
46L-methionine salvage (GO:0071267)2.91654359
47L-methionine biosynthetic process (GO:0071265)2.91654359
48dopamine transport (GO:0015872)2.91073602
49regulation of centrosome cycle (GO:0046605)2.87058376
50cyclic nucleotide catabolic process (GO:0009214)2.85777690
51cAMP catabolic process (GO:0006198)2.84394215
52methionine biosynthetic process (GO:0009086)2.83707472
53folic acid-containing compound biosynthetic process (GO:0009396)2.83482815
54aspartate family amino acid biosynthetic process (GO:0009067)2.82904802
55preassembly of GPI anchor in ER membrane (GO:0016254)2.78173670
56regulation of centrosome duplication (GO:0010824)2.77015104
57negative regulation of protein activation cascade (GO:2000258)2.76050486
58estrogen biosynthetic process (GO:0006703)2.75572293
59regulation of glucokinase activity (GO:0033131)2.74586157
60regulation of hexokinase activity (GO:1903299)2.74586157
61photoreceptor cell maintenance (GO:0045494)2.73912131
62negative regulation of transcription by competitive promoter binding (GO:0010944)2.73178034
63C-terminal protein amino acid modification (GO:0018410)2.73104329
64detection of light stimulus involved in visual perception (GO:0050908)2.70142975
65detection of light stimulus involved in sensory perception (GO:0050962)2.70142975
66mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.67455831
67calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)2.66097157
68GPI anchor biosynthetic process (GO:0006506)2.66032334
69mitochondrial RNA metabolic process (GO:0000959)2.66013082
70sulfur amino acid biosynthetic process (GO:0000097)2.65563300
71C-terminal protein lipidation (GO:0006501)2.64049480
72methionine metabolic process (GO:0006555)2.59450689
73CENP-A containing nucleosome assembly (GO:0034080)2.57704948
74folic acid-containing compound metabolic process (GO:0006760)2.55523496
75dolichol-linked oligosaccharide biosynthetic process (GO:0006488)2.54788009
76signal peptide processing (GO:0006465)2.53095990
77S-adenosylmethionine metabolic process (GO:0046500)2.52593570
78centriole replication (GO:0007099)2.51303714
79protein localization to kinetochore (GO:0034501)2.50101500
80cellular ketone metabolic process (GO:0042180)2.48352768
81axoneme assembly (GO:0035082)2.47482123
82ribonucleoprotein complex disassembly (GO:0032988)2.47305346
83exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.45607103
84protein complex biogenesis (GO:0070271)2.45443199
85female gamete generation (GO:0007292)2.45014141
86peptidyl-histidine modification (GO:0018202)2.45002751
87chromatin remodeling at centromere (GO:0031055)2.44951620
88anterograde synaptic vesicle transport (GO:0048490)2.44760644
89behavioral response to ethanol (GO:0048149)2.42187288
90intra-S DNA damage checkpoint (GO:0031573)2.41555329
91mannosylation (GO:0097502)2.41248995
92nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.40309924
93UDP-N-acetylglucosamine metabolic process (GO:0006047)2.39735051
94oxidative phosphorylation (GO:0006119)2.39688085
95keratinocyte development (GO:0003334)2.39447385
96double-strand break repair via homologous recombination (GO:0000724)2.39347381
97midgut development (GO:0007494)2.38612260
98recombinational repair (GO:0000725)2.37062846
99snRNA transcription (GO:0009301)2.35008335
100pteridine-containing compound metabolic process (GO:0042558)2.34550472

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse7.55561932
2E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse7.54480345
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.57359062
4GABP_17652178_ChIP-ChIP_JURKAT_Human2.70127652
5EST1_17652178_ChIP-ChIP_JURKAT_Human2.60485896
6POU3F2_20337985_ChIP-ChIP_501MEL_Human2.47282289
7FUS_26573619_Chip-Seq_HEK293_Human2.43590168
8IGF1R_20145208_ChIP-Seq_DFB_Human2.40507735
9EWS_26573619_Chip-Seq_HEK293_Human2.35610949
10ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.31123244
11HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.28715629
12SALL1_21062744_ChIP-ChIP_HESCs_Human2.25600975
13VDR_22108803_ChIP-Seq_LS180_Human2.21814827
14ZFP57_27257070_Chip-Seq_ESCs_Mouse2.19110648
15MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.10196471
16ZNF274_21170338_ChIP-Seq_K562_Hela2.04806135
17NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.01928729
18BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.93509619
19ELK1_19687146_ChIP-ChIP_HELA_Human1.92750795
20GBX2_23144817_ChIP-Seq_PC3_Human1.83347004
21CTBP2_25329375_ChIP-Seq_LNCAP_Human1.78053349
22PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.78000746
23E2F7_22180533_ChIP-Seq_HELA_Human1.77687937
24JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.74582685
25MYC_18940864_ChIP-ChIP_HL60_Human1.74328232
26E2F4_17652178_ChIP-ChIP_JURKAT_Human1.74116406
27CREB1_15753290_ChIP-ChIP_HEK293T_Human1.66672368
28P300_19829295_ChIP-Seq_ESCs_Human1.66532340
29TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.64927786
30ETS1_20019798_ChIP-Seq_JURKAT_Human1.64662119
31CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.62196478
32TAF15_26573619_Chip-Seq_HEK293_Human1.62178030
33FLI1_27457419_Chip-Seq_LIVER_Mouse1.56150088
34PADI4_21655091_ChIP-ChIP_MCF-7_Human1.49819820
35DCP1A_22483619_ChIP-Seq_HELA_Human1.48360279
36PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.48065035
37ZNF263_19887448_ChIP-Seq_K562_Human1.42210856
38CTBP1_25329375_ChIP-Seq_LNCAP_Human1.37235513
39VDR_23849224_ChIP-Seq_CD4+_Human1.36004850
40MYC_18555785_ChIP-Seq_MESCs_Mouse1.33476154
41GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.29237041
42RBPJ_22232070_ChIP-Seq_NCS_Mouse1.28542353
43TP53_22573176_ChIP-Seq_HFKS_Human1.27886103
44FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.27060933
45EZH2_27294783_Chip-Seq_NPCs_Mouse1.25124412
46AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.21138964
47MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.20050901
48* STAT3_23295773_ChIP-Seq_U87_Human1.19768928
49SUZ12_27294783_Chip-Seq_NPCs_Mouse1.17065081
50ER_23166858_ChIP-Seq_MCF-7_Human1.16610049
51PCGF2_27294783_Chip-Seq_ESCs_Mouse1.13130758
52CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.13024726
53UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.10188774
54TCF4_22108803_ChIP-Seq_LS180_Human1.09257773
55YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.07783481
56HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.06846212
57NANOG_19829295_ChIP-Seq_ESCs_Human1.05973276
58SOX2_19829295_ChIP-Seq_ESCs_Human1.05973276
59NFE2_27457419_Chip-Seq_LIVER_Mouse1.04854050
60FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.02876614
61KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.02369768
62SRF_21415370_ChIP-Seq_HL-1_Mouse1.01765109
63RNF2_27304074_Chip-Seq_NSC_Mouse1.01188249
64CRX_20693478_ChIP-Seq_RETINA_Mouse1.01118578
65SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.00802705
66PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.99435273
67FOXP3_21729870_ChIP-Seq_TREG_Human0.99309052
68CBP_20019798_ChIP-Seq_JUKART_Human0.99023081
69IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.99023081
70TP63_19390658_ChIP-ChIP_HaCaT_Human0.98375340
71AR_25329375_ChIP-Seq_VCAP_Human0.98110527
72SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.96983482
73BMI1_23680149_ChIP-Seq_NPCS_Mouse0.96402462
74PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.95494045
75OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.94362132
76CBX2_27304074_Chip-Seq_ESCs_Mouse0.94009038
77PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.92864786
78MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.91168576
79RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.90635546
80RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.90576347
81EGR1_23403033_ChIP-Seq_LIVER_Mouse0.90422916
82NRF2_20460467_ChIP-Seq_MEFs_Mouse0.89888172
83NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.89888172
84TCF4_23295773_ChIP-Seq_U87_Human0.89850547
85TTF2_22483619_ChIP-Seq_HELA_Human0.89401258
86NOTCH1_21737748_ChIP-Seq_TLL_Human0.88883369
87FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.88739405
88FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.88299436
89CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.88227710
90CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.88219829
91JUN_21703547_ChIP-Seq_K562_Human0.87080068
92KLF5_20875108_ChIP-Seq_MESCs_Mouse0.86470369
93FOXM1_23109430_ChIP-Seq_U2OS_Human0.86432744
94EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.86429544
95E2F1_21310950_ChIP-Seq_MCF-7_Human0.86160750
96FLI1_21867929_ChIP-Seq_TH2_Mouse0.85487624
97THAP11_20581084_ChIP-Seq_MESCs_Mouse0.85240381
98CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.85201712
99SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.84631462
100HTT_18923047_ChIP-ChIP_STHdh_Human0.83400844

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005645_abnormal_hypothalamus_physiol4.51814701
2MP0008058_abnormal_DNA_repair3.88379211
3MP0008057_abnormal_DNA_replication3.48293607
4MP0000013_abnormal_adipose_tissue3.43314544
5MP0000569_abnormal_digit_pigmentation3.00525686
6MP0000015_abnormal_ear_pigmentation2.78933384
7MP0005670_abnormal_white_adipose2.28825811
8MP0002139_abnormal_hepatobiliary_system2.28307600
9MP0004133_heterotaxia2.20972424
10MP0010094_abnormal_chromosome_stability2.05387891
11MP0003718_maternal_effect2.03119493
12MP0003186_abnormal_redox_activity2.02810918
13MP0002138_abnormal_hepatobiliary_system1.95364453
14MP0005084_abnormal_gallbladder_morpholo1.85918105
15MP0002160_abnormal_reproductive_system1.84069067
16MP0002876_abnormal_thyroid_physiology1.75076486
17MP0008995_early_reproductive_senescence1.71522579
18MP0000003_abnormal_adipose_tissue1.70449934
19MP0005551_abnormal_eye_electrophysiolog1.67729791
20MP0008932_abnormal_embryonic_tissue1.67058455
21MP0008875_abnormal_xenobiotic_pharmacok1.64895278
22MP0000372_irregular_coat_pigmentation1.61010506
23MP0006035_abnormal_mitochondrial_morpho1.58665411
24MP0002938_white_spotting1.58045263
25MP0009046_muscle_twitch1.53667569
26MP0000631_abnormal_neuroendocrine_gland1.50850379
27MP0005389_reproductive_system_phenotype1.50332890
28MP0002837_dystrophic_cardiac_calcinosis1.50178263
29MP0005647_abnormal_sex_gland1.49509811
30MP0008877_abnormal_DNA_methylation1.49007130
31MP0003195_calcinosis1.48193498
32MP0003880_abnormal_central_pattern1.42643960
33MP0000383_abnormal_hair_follicle1.41122821
34MP0005174_abnormal_tail_pigmentation1.41028809
35MP0002234_abnormal_pharynx_morphology1.40801389
36MP0005623_abnormal_meninges_morphology1.40765845
37MP0002928_abnormal_bile_duct1.39903940
38MP0003950_abnormal_plasma_membrane1.38430456
39MP0003786_premature_aging1.36918898
40MP0006276_abnormal_autonomic_nervous1.35663959
41MP0004233_abnormal_muscle_weight1.31653081
42MP0009697_abnormal_copulation1.30164874
43MP0001919_abnormal_reproductive_system1.26731966
44MP0008789_abnormal_olfactory_epithelium1.25428001
45MP0000427_abnormal_hair_cycle1.24874754
46MP0002095_abnormal_skin_pigmentation1.23176797
47MP0001929_abnormal_gametogenesis1.22759286
48MP0003938_abnormal_ear_development1.21792819
49MP0003077_abnormal_cell_cycle1.21688543
50MP0006036_abnormal_mitochondrial_physio1.21535339
51MP0005410_abnormal_fertilization1.17442624
52MP0008872_abnormal_physiological_respon1.17398252
53MP0004957_abnormal_blastocyst_morpholog1.16805115
54MP0004145_abnormal_muscle_electrophysio1.15032109
55MP0001119_abnormal_female_reproductive1.13516481
56MP0002210_abnormal_sex_determination1.12077317
57MP0000647_abnormal_sebaceous_gland1.11770669
58MP0005332_abnormal_amino_acid1.11078961
59MP0001502_abnormal_circadian_rhythm1.10777285
60MP0005408_hypopigmentation1.09480192
61MP0003698_abnormal_male_reproductive1.09062984
62MP0004147_increased_porphyrin_level1.07930048
63MP0005187_abnormal_penis_morphology1.07842933
64MP0003045_fibrosis1.07338014
65MP0003806_abnormal_nucleotide_metabolis1.06837483
66MP0008775_abnormal_heart_ventricle1.06707815
67MP0003879_abnormal_hair_cell1.05856735
68MP0000653_abnormal_sex_gland1.05805996
69MP0005220_abnormal_exocrine_pancreas1.05261969
70MP0000538_abnormal_urinary_bladder1.02556354
71MP0005395_other_phenotype1.00870833
72MP0002102_abnormal_ear_morphology0.97040806
73MP0000358_abnormal_cell_content/0.96908521
74MP0000049_abnormal_middle_ear0.95779567
75MP0010678_abnormal_skin_adnexa0.94936439
76MP0002971_abnormal_brown_adipose0.94794441
77MP0001881_abnormal_mammary_gland0.94237679
78MP0006072_abnormal_retinal_apoptosis0.93288944
79MP0003937_abnormal_limbs/digits/tail_de0.91598094
80MP0002090_abnormal_vision0.88014086
81MP0002736_abnormal_nociception_after0.87281241
82MP0002272_abnormal_nervous_system0.86646140
83MP0001145_abnormal_male_reproductive0.84520335
84MP0005334_abnormal_fat_pad0.83844797
85MP0001270_distended_abdomen0.83828359
86MP0009745_abnormal_behavioral_response0.82967130
87MP0001764_abnormal_homeostasis0.81546113
88MP0002184_abnormal_innervation0.81492269
89MP0005375_adipose_tissue_phenotype0.81176128
90MP0004043_abnormal_pH_regulation0.80856456
91MP0004019_abnormal_vitamin_homeostasis0.80118710
92MP0005379_endocrine/exocrine_gland_phen0.77814763
93MP0005253_abnormal_eye_physiology0.77575748
94MP0002697_abnormal_eye_size0.76822027
95MP0003137_abnormal_impulse_conducting0.74989963
96MP0001529_abnormal_vocalization0.74096585
97MP0002233_abnormal_nose_morphology0.72743389
98MP0003119_abnormal_digestive_system0.71620772
99MP0002277_abnormal_respiratory_mucosa0.70190886
100MP0003943_abnormal_hepatobiliary_system0.69360334

Predicted human phenotypes

RankGene SetZ-score
1Pancreatic cysts (HP:0001737)3.91472027
2Pancreatic fibrosis (HP:0100732)3.83189818
3Abnormality of the renal cortex (HP:0011035)3.20220258
4Albinism (HP:0001022)3.20154001
5Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.18612810
6Abnormality of alanine metabolism (HP:0010916)3.18612810
7Hyperalaninemia (HP:0003348)3.18612810
83-Methylglutaconic aciduria (HP:0003535)3.17811773
9Oligodactyly (hands) (HP:0001180)3.11558419
10Methylmalonic acidemia (HP:0002912)2.89093160
11Fair hair (HP:0002286)2.83997917
12Hyperventilation (HP:0002883)2.78727522
13Cystic liver disease (HP:0006706)2.75074695
14Aplasia/Hypoplasia of the uvula (HP:0010293)2.74038835
15Polydipsia (HP:0001959)2.73533306
16Abnormal drinking behavior (HP:0030082)2.73533306
17Type II lissencephaly (HP:0007260)2.71219749
18True hermaphroditism (HP:0010459)2.68268492
19Birth length less than 3rd percentile (HP:0003561)2.66486277
20Increased CSF lactate (HP:0002490)2.66112768
21Cerebral edema (HP:0002181)2.59898480
22Abnormality of serum amino acid levels (HP:0003112)2.56527808
23Abnormality of the pons (HP:0007361)2.56204424
24Absent speech (HP:0001344)2.54876803
25Metaphyseal dysplasia (HP:0100255)2.54370892
26Tubular atrophy (HP:0000092)2.47994961
27Increased hepatocellular lipid droplets (HP:0006565)2.44861313
28Abnormality of chromosome stability (HP:0003220)2.44112533
29Muscle hypertrophy of the lower extremities (HP:0008968)2.43861966
30Hypoplasia of the pons (HP:0012110)2.42605443
31Gaze-evoked nystagmus (HP:0000640)2.41524942
32Abnormal mitochondria in muscle tissue (HP:0008316)2.39466500
33Acute necrotizing encephalopathy (HP:0006965)2.38660045
34Increased serum pyruvate (HP:0003542)2.34226885
35Polyuria (HP:0000103)2.33185813
36Cutaneous melanoma (HP:0012056)2.32979851
37Split foot (HP:0001839)2.31430663
38Methylmalonic aciduria (HP:0012120)2.31214991
39Hyperglycinemia (HP:0002154)2.29032402
40Abnormality of glycolysis (HP:0004366)2.28151076
41Small hand (HP:0200055)2.24985243
42Lipid accumulation in hepatocytes (HP:0006561)2.23403160
43Supernumerary spleens (HP:0009799)2.22481996
44Congenital sensorineural hearing impairment (HP:0008527)2.21199294
45Abnormality of methionine metabolism (HP:0010901)2.21069068
46Abnormality of the preputium (HP:0100587)2.19890354
47Increased serum lactate (HP:0002151)2.19797045
48Acute encephalopathy (HP:0006846)2.19395782
49Abnormality of vitamin B metabolism (HP:0004340)2.17383045
50Abnormality of the vitamin B12 metabolism (HP:0004341)2.16577865
51Reduced antithrombin III activity (HP:0001976)2.16513110
52Abnormality of the ileum (HP:0001549)2.14795259
53Progressive macrocephaly (HP:0004481)2.14167965
54Hypokinesia (HP:0002375)2.13813576
55Abnormal biliary tract physiology (HP:0012439)2.13764143
56Bile duct proliferation (HP:0001408)2.13764143
57Tubulointerstitial fibrosis (HP:0005576)2.13299285
58Microvesicular hepatic steatosis (HP:0001414)2.13050103
59Renal cortical cysts (HP:0000803)2.12753435
60Mitochondrial inheritance (HP:0001427)2.12481590
61Meckel diverticulum (HP:0002245)2.12215336
62Renal Fanconi syndrome (HP:0001994)2.10504202
63Chromosomal breakage induced by crosslinking agents (HP:0003221)2.09913493
64Retinal dysplasia (HP:0007973)2.09715377
65Abnormal rod and cone electroretinograms (HP:0008323)2.08248968
66Duodenal stenosis (HP:0100867)2.06442001
67Small intestinal stenosis (HP:0012848)2.06442001
68Aplasia/Hypoplasia of the tibia (HP:0005772)2.04981262
69Abnormality of the renal medulla (HP:0100957)2.02110540
70Cerebellar dysplasia (HP:0007033)1.98095631
71Attenuation of retinal blood vessels (HP:0007843)1.96831003
72Intestinal atresia (HP:0011100)1.96770647
73Dyskinesia (HP:0100660)1.96564541
74Chromsome breakage (HP:0040012)1.95844368
75Type I transferrin isoform profile (HP:0003642)1.95057431
76Lactic acidosis (HP:0003128)1.91661243
77Tubulointerstitial abnormality (HP:0001969)1.90980446
78Absent rod-and cone-mediated responses on ERG (HP:0007688)1.89981562
79Stomach cancer (HP:0012126)1.89649529
80Medial flaring of the eyebrow (HP:0010747)1.89325718
81Molar tooth sign on MRI (HP:0002419)1.89303673
82Abnormality of midbrain morphology (HP:0002418)1.89303673
83Hypomagnesemia (HP:0002917)1.87967723
84Neoplasm of the oral cavity (HP:0100649)1.87101420
85Tetany (HP:0001281)1.86529861
86Squamous cell carcinoma (HP:0002860)1.86315245
87Progressive inability to walk (HP:0002505)1.86196722
88Homocystinuria (HP:0002156)1.84710213
89Abnormality of homocysteine metabolism (HP:0010919)1.84710213
90Ketosis (HP:0001946)1.81945922
91Bony spicule pigmentary retinopathy (HP:0007737)1.81466535
92Generalized hypopigmentation of hair (HP:0011358)1.81461720
93Volvulus (HP:0002580)1.81371032
94Abnormality of the duodenum (HP:0002246)1.81145100
95Proximal tubulopathy (HP:0000114)1.80835151
96Inability to walk (HP:0002540)1.80309325
97Abnormal protein glycosylation (HP:0012346)1.80277096
98Abnormal glycosylation (HP:0012345)1.80277096
99Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.80277096
100Abnormal protein N-linked glycosylation (HP:0012347)1.80277096

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK24.91520203
2FRK3.86685863
3MKNK13.25649544
4EIF2AK12.69634868
5PINK12.61484571
6CASK2.43915563
7NEK12.30001428
8MKNK22.29530525
9DYRK32.29271423
10MAPKAPK32.23971930
11ACVR1B2.17838262
12ZAK2.00481697
13RPS6KB21.97554976
14TLK11.85962373
15OXSR11.84335572
16BMPR1B1.77889578
17BRSK21.77289845
18STK391.73963370
19PLK41.73947930
20CCNB11.73376889
21PBK1.71787384
22SRPK11.66401881
23TRIM281.62402621
24CDC71.58632826
25MAP4K21.57026576
26WNK31.56963555
27MELK1.56697489
28TAOK31.54572555
29ADRBK21.46412547
30ERBB31.46372374
31AKT31.42879916
32STK161.41724200
33MAPKAPK51.40240018
34INSRR1.35379947
35MAPK131.33061508
36NEK21.18400587
37CDK81.17865626
38EIF2AK31.17384300
39TTK1.15929330
40BUB11.14791096
41STK381.13492536
42MAP3K41.13331834
43ABL21.08797832
44BCR1.02494084
45WEE11.01277692
46PLK31.00765629
47MST41.00012834
48NTRK20.98733329
49NME20.94605540
50MAP2K70.94587616
51STK30.94514325
52MST1R0.93902596
53CSNK1G10.92655430
54GRK10.89859983
55TGFBR10.89094967
56PLK10.84367756
57MUSK0.82794865
58PRKCE0.74330974
59RPS6KA50.73424228
60MARK10.70959401
61CSNK1A1L0.70515567
62CSNK1G30.69973135
63FER0.69537007
64PLK20.67406805
65BRSK10.64365209
66NUAK10.61289083
67CAMKK20.61038899
68ERBB40.57910341
69PAK30.55062458
70ATR0.53327137
71CSNK1G20.53266882
72CAMK2A0.49064709
73ATM0.48259709
74PRKCG0.48142413
75WNK40.47182788
76STK40.45923182
77MAP2K60.44199580
78RPS6KA40.43998604
79AURKB0.42930787
80ADRBK10.42590151
81PIK3CG0.39878196
82CHEK20.39379813
83PRKCI0.38932509
84NME10.38575741
85MAP3K120.37404851
86SIK30.34945239
87CSNK2A10.34565848
88TSSK60.34543709
89MARK30.33721158
90ABL10.33285171
91PIM20.30137382
92PRKACB0.30079055
93PKN10.29862649
94DYRK1A0.29703926
95TGFBR20.27967126
96CAMK2D0.27565103
97CSNK1E0.24906045
98PRKACA0.24431970
99CDK10.24132366
100PRKCA0.21765806

Predicted pathways (KEGG)

RankGene SetZ-score
1Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001304.41534591
2Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.92232931
3Nitrogen metabolism_Homo sapiens_hsa009102.48963870
4Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.45933012
5Fanconi anemia pathway_Homo sapiens_hsa034602.36871147
6Oxidative phosphorylation_Homo sapiens_hsa001902.26703379
7Protein export_Homo sapiens_hsa030602.19646423
8Vitamin B6 metabolism_Homo sapiens_hsa007502.15882108
9Homologous recombination_Homo sapiens_hsa034402.07565593
10One carbon pool by folate_Homo sapiens_hsa006702.06880363
11Folate biosynthesis_Homo sapiens_hsa007901.92337785
12Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.89001748
13Mismatch repair_Homo sapiens_hsa034301.84536469
14Steroid hormone biosynthesis_Homo sapiens_hsa001401.64784683
15Sulfur relay system_Homo sapiens_hsa041221.64125430
16Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.61023053
17Parkinsons disease_Homo sapiens_hsa050121.60593439
18Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.59679515
19Ether lipid metabolism_Homo sapiens_hsa005651.58959748
20Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.56386805
21Butanoate metabolism_Homo sapiens_hsa006501.51187342
22Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.51059711
23Fatty acid elongation_Homo sapiens_hsa000621.50859078
24Cysteine and methionine metabolism_Homo sapiens_hsa002701.50219736
25Non-homologous end-joining_Homo sapiens_hsa034501.47067107
26Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.45852023
27Ribosome_Homo sapiens_hsa030101.45534665
28Nucleotide excision repair_Homo sapiens_hsa034201.45287368
29DNA replication_Homo sapiens_hsa030301.45253291
30Propanoate metabolism_Homo sapiens_hsa006401.42401458
31Ovarian steroidogenesis_Homo sapiens_hsa049131.39704031
32Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.38679243
33Linoleic acid metabolism_Homo sapiens_hsa005911.35611254
34Proteasome_Homo sapiens_hsa030501.34628755
35alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.31122623
36Basal transcription factors_Homo sapiens_hsa030221.30499060
37Selenocompound metabolism_Homo sapiens_hsa004501.30195159
38RNA degradation_Homo sapiens_hsa030181.26699793
39Peroxisome_Homo sapiens_hsa041461.25128799
40Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.20941600
41Chemical carcinogenesis_Homo sapiens_hsa052041.16002077
42Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.14649192
43Glutathione metabolism_Homo sapiens_hsa004801.12416251
44Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.11266076
45RNA polymerase_Homo sapiens_hsa030201.11220649
46Maturity onset diabetes of the young_Homo sapiens_hsa049501.10182105
47RNA transport_Homo sapiens_hsa030131.07404815
48Huntingtons disease_Homo sapiens_hsa050161.06899341
49Base excision repair_Homo sapiens_hsa034101.04064976
50Collecting duct acid secretion_Homo sapiens_hsa049661.03537525
51Purine metabolism_Homo sapiens_hsa002300.99150523
52Pyruvate metabolism_Homo sapiens_hsa006200.98392840
53Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.98367298
54Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.94964536
55N-Glycan biosynthesis_Homo sapiens_hsa005100.91934351
56Metabolic pathways_Homo sapiens_hsa011000.91784259
57Alzheimers disease_Homo sapiens_hsa050100.90366715
58Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.84949424
59Pentose and glucuronate interconversions_Homo sapiens_hsa000400.84445259
60Retinol metabolism_Homo sapiens_hsa008300.83897141
61Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.83210213
62Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.81532034
63Arginine biosynthesis_Homo sapiens_hsa002200.81060724
64Arachidonic acid metabolism_Homo sapiens_hsa005900.79848780
65Caffeine metabolism_Homo sapiens_hsa002320.77988226
66Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.77446519
67Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.77174596
68Regulation of autophagy_Homo sapiens_hsa041400.76925721
69Phototransduction_Homo sapiens_hsa047440.75010458
70Circadian rhythm_Homo sapiens_hsa047100.74197274
71Olfactory transduction_Homo sapiens_hsa047400.73359755
72Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.72980959
73Nicotine addiction_Homo sapiens_hsa050330.72549712
74Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.71207711
75Sulfur metabolism_Homo sapiens_hsa009200.71098644
76beta-Alanine metabolism_Homo sapiens_hsa004100.70986884
77Tryptophan metabolism_Homo sapiens_hsa003800.70427255
78Pyrimidine metabolism_Homo sapiens_hsa002400.70213569
79Starch and sucrose metabolism_Homo sapiens_hsa005000.69696030
80Primary bile acid biosynthesis_Homo sapiens_hsa001200.67328062
81ABC transporters_Homo sapiens_hsa020100.65761782
82Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.62701605
83Steroid biosynthesis_Homo sapiens_hsa001000.60189014
84Morphine addiction_Homo sapiens_hsa050320.60020416
85Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.59447975
86Histidine metabolism_Homo sapiens_hsa003400.55652877
87Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.55094746
88Spliceosome_Homo sapiens_hsa030400.52974562
89Taste transduction_Homo sapiens_hsa047420.52128757
90Biosynthesis of amino acids_Homo sapiens_hsa012300.49347203
91TGF-beta signaling pathway_Homo sapiens_hsa043500.48831878
92Cell cycle_Homo sapiens_hsa041100.46272548
93GABAergic synapse_Homo sapiens_hsa047270.46045134
94Pentose phosphate pathway_Homo sapiens_hsa000300.37863666
95Galactose metabolism_Homo sapiens_hsa000520.37740741
96Fatty acid metabolism_Homo sapiens_hsa012120.37117874
97Glutamatergic synapse_Homo sapiens_hsa047240.35912869
98Fatty acid biosynthesis_Homo sapiens_hsa000610.34478620
99Cardiac muscle contraction_Homo sapiens_hsa042600.33951929
100Cyanoamino acid metabolism_Homo sapiens_hsa004600.33147869

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