INSL5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene contains a classical signature of the insulin superfamily and is highly similar to relaxin 3 (RLN3/INSL7). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1sulfate transmembrane transport (GO:1902358)8.84101195
2transcytosis (GO:0045056)8.00134919
3regulation of systemic arterial blood pressure by hormone (GO:0001990)7.72797564
4regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)7.72797564
5endocrine process (GO:0050886)7.72797564
6interferon-gamma secretion (GO:0072643)7.34328821
7sulfate transport (GO:0008272)7.28523684
8regulation of neuron projection regeneration (GO:0070570)7.27820475
9regulation of axon regeneration (GO:0048679)7.27820475
10positive regulation of respiratory burst (GO:0060267)7.19978817
11keratinocyte proliferation (GO:0043616)7.10028162
12microtubule depolymerization (GO:0007019)6.66170531
13bicarbonate transport (GO:0015701)6.09085708
14regulation of systemic arterial blood pressure (GO:0003073)6.00260489
15cGMP biosynthetic process (GO:0006182)6.00055122
16negative regulation of neurological system process (GO:0031645)5.99803705
17calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)5.56208694
18bundle of His cell to Purkinje myocyte communication (GO:0086069)5.41684131
19glomerular filtration (GO:0003094)5.34516878
20sperm capacitation (GO:0048240)5.01006066
21cGMP-mediated signaling (GO:0019934)4.95640657
22microtubule polymerization or depolymerization (GO:0031109)4.91693986
23regulation of respiratory burst (GO:0060263)4.88666916
24renal filtration (GO:0097205)4.82584821
25cGMP metabolic process (GO:0046068)4.76459925
26keratinocyte development (GO:0003334)4.74535223
27oligosaccharide biosynthetic process (GO:0009312)4.52193994
28forebrain neuron differentiation (GO:0021879)4.50741194
29presynaptic membrane assembly (GO:0097105)4.50170723
30protein localization to synapse (GO:0035418)4.46876864
31regulation of transforming growth factor beta1 production (GO:0032908)4.39577138
32vocalization behavior (GO:0071625)4.36270753
33regulation of intracellular pH (GO:0051453)4.34887831
34neuron cell-cell adhesion (GO:0007158)4.32335681
35oligosaccharide catabolic process (GO:0009313)4.32324475
36positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.27760189
37retina homeostasis (GO:0001895)4.23645876
38locomotory exploration behavior (GO:0035641)4.17855614
39cellular response to pH (GO:0071467)4.16409854
40postsynaptic membrane organization (GO:0001941)4.15283039
41ethanol oxidation (GO:0006069)4.09347387
42exploration behavior (GO:0035640)4.06592847
43mitochondrion transport along microtubule (GO:0047497)4.03233919
44establishment of mitochondrion localization, microtubule-mediated (GO:0034643)4.03233919
45intestinal absorption (GO:0050892)4.02460800
46positive regulation of synaptic transmission, GABAergic (GO:0032230)3.99982450
47regulation of cellular pH (GO:0030641)3.98067077
48chondrocyte proliferation (GO:0035988)3.97673443
49pyrimidine-containing compound transmembrane transport (GO:0072531)3.92136813
50positive T cell selection (GO:0043368)3.91801625
51presynaptic membrane organization (GO:0097090)3.91306400
52regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.90989935
53regulation of glutamate receptor signaling pathway (GO:1900449)3.89392794
54negative regulation of viral entry into host cell (GO:0046597)3.83877170
55sensory perception of smell (GO:0007608)3.82941562
56negative regulation of cell killing (GO:0031342)3.81998967
57negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.81998967
58establishment of mitochondrion localization (GO:0051654)3.80574505
59protein depolymerization (GO:0051261)3.77387898
60regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.74973682
613-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)3.74123321
62purine ribonucleoside bisphosphate metabolic process (GO:0034035)3.74123321
63behavioral fear response (GO:0001662)3.73903224
64behavioral defense response (GO:0002209)3.73903224
65one-carbon metabolic process (GO:0006730)3.67442076
66cellular glucuronidation (GO:0052695)3.66723477
67cyclic purine nucleotide metabolic process (GO:0052652)3.65397413
68response to interferon-beta (GO:0035456)3.62734833
69regulation of viral entry into host cell (GO:0046596)3.61388015
70endothelial cell morphogenesis (GO:0001886)3.55775934
71negative regulation of metanephros development (GO:0072217)3.52831108
72O-glycan processing (GO:0016266)3.48463308
73branching involved in labyrinthine layer morphogenesis (GO:0060670)3.48080260
74cyclic nucleotide biosynthetic process (GO:0009190)3.46202603
75sulfur compound transport (GO:0072348)3.44385359
76glutamate receptor signaling pathway (GO:0007215)3.40953418
77substrate-independent telencephalic tangential interneuron migration (GO:0021843)3.40283047
78substrate-independent telencephalic tangential migration (GO:0021826)3.40283047
79serotonin metabolic process (GO:0042428)3.40204027
80primary alcohol catabolic process (GO:0034310)3.40055391
81transmission of nerve impulse (GO:0019226)3.39557689
82synaptonemal complex assembly (GO:0007130)3.39000211
83protein localization to cilium (GO:0061512)3.38898644
84uronic acid metabolic process (GO:0006063)3.38885501
85glucuronate metabolic process (GO:0019585)3.38885501
86regulation of protein kinase A signaling (GO:0010738)3.38205065
87response to interferon-alpha (GO:0035455)3.38199894
88positive regulation of dendritic spine morphogenesis (GO:0061003)3.38182194
89fear response (GO:0042596)3.36070700
90V(D)J recombination (GO:0033151)3.35019665
91response to protozoan (GO:0001562)3.34990596
92response to acidic pH (GO:0010447)3.33692736
93regulation of apoptotic process involved in morphogenesis (GO:1902337)3.33445026
94UDP-N-acetylglucosamine metabolic process (GO:0006047)3.32525460
95regulation of short-term neuronal synaptic plasticity (GO:0048172)3.32513899
96respiratory tube development (GO:0030323)3.31820687
97ear development (GO:0043583)3.30120191
98viral protein processing (GO:0019082)3.30064839
99regulation of dendritic spine morphogenesis (GO:0061001)3.27304129
100G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.25236878
101regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)3.24920570
102response to histamine (GO:0034776)3.24711734
103sialylation (GO:0097503)3.24194457
104membrane hyperpolarization (GO:0060081)3.23734141
105regulation of nephron tubule epithelial cell differentiation (GO:0072182)3.22517116
106regulation of synaptic vesicle exocytosis (GO:2000300)3.21450264
107cellular monovalent inorganic cation homeostasis (GO:0030004)3.19831283
108negative regulation of myotube differentiation (GO:0010832)3.19275262
109behavioral response to cocaine (GO:0048148)3.18165415
110ionotropic glutamate receptor signaling pathway (GO:0035235)3.16999323
111nephron tubule formation (GO:0072079)3.16348016
112detection of calcium ion (GO:0005513)3.16120452
113respiratory burst (GO:0045730)3.16003774
114positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.14467687
115chromosome organization involved in meiosis (GO:0070192)3.14049761
116mating behavior (GO:0007617)3.13939148
117gamma-aminobutyric acid signaling pathway (GO:0007214)3.12627354
118ethanol metabolic process (GO:0006067)3.12383593
119regulation of guanylate cyclase activity (GO:0031282)3.11601090
120glycogen biosynthetic process (GO:0005978)3.08125650
121glucan biosynthetic process (GO:0009250)3.08125650
122synapsis (GO:0007129)3.05419554
123gap junction assembly (GO:0016264)3.05307916
124superoxide anion generation (GO:0042554)3.05041797
125metanephric nephron tubule development (GO:0072234)3.04627483
126metanephric tubule development (GO:0072170)3.04627483
127antibacterial humoral response (GO:0019731)3.04493954
128detection of chemical stimulus involved in sensory perception of taste (GO:0050912)3.02958185
129G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.01914317
130ventricular cardiac muscle cell action potential (GO:0086005)2.99957960
131righting reflex (GO:0060013)2.99882919
132detection of chemical stimulus involved in sensory perception of bitter taste (GO:0001580)2.98889509
133regulation of female receptivity (GO:0045924)2.98327130
134regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.98305612
135desmosome organization (GO:0002934)2.98293402
136synaptonemal complex organization (GO:0070193)2.97841609
137positive regulation of response to oxidative stress (GO:1902884)2.97096745
138positive regulation of cellular response to oxidative stress (GO:1900409)2.97096745
139purine nucleoside bisphosphate biosynthetic process (GO:0034033)2.95887259
140ribonucleoside bisphosphate biosynthetic process (GO:0034030)2.95887259
141nucleoside bisphosphate biosynthetic process (GO:0033866)2.95887259
142positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.95308968
143synaptic transmission, glutamatergic (GO:0035249)2.92938738
144synaptic vesicle exocytosis (GO:0016079)2.92287693
145regulation of excitatory postsynaptic membrane potential (GO:0060079)2.91735301
146negative regulation of keratinocyte proliferation (GO:0010839)2.91567451
147long-term memory (GO:0007616)2.91177644
148cerebellar granule cell differentiation (GO:0021707)2.90228814
149positive regulation of synapse assembly (GO:0051965)2.89433004
150mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)2.88395113
151positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021102.88395113
152antimicrobial humoral response (GO:0019730)2.87235325
153primary amino compound metabolic process (GO:1901160)2.83772332
154auditory receptor cell differentiation (GO:0042491)2.82972166
155response to pH (GO:0009268)2.82733911
156neuron-neuron synaptic transmission (GO:0007270)2.82455690
157lipid translocation (GO:0034204)2.82088617
158phospholipid translocation (GO:0045332)2.82088617
159activation of protein kinase A activity (GO:0034199)2.80727604
160metanephric epithelium development (GO:0072207)2.80152034
161N-acetylneuraminate metabolic process (GO:0006054)2.79340456
162female mating behavior (GO:0060180)2.79001138
163regulation of pH (GO:0006885)2.78544103
164complement activation, classical pathway (GO:0006958)2.78320774
165regulation of synaptic transmission, GABAergic (GO:0032228)2.77970314
166membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.77865591
167metanephric nephron epithelium development (GO:0072243)2.77831314
168neuronal action potential propagation (GO:0019227)2.76928286
169male meiosis I (GO:0007141)2.76561427
170neurotransmitter secretion (GO:0007269)2.74616047
171regulation of postsynaptic membrane potential (GO:0060078)2.74145467
172regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.73729548
173excretion (GO:0007588)2.72460052
174regulation of synaptic vesicle transport (GO:1902803)2.71537044
175signal transduction involved in regulation of gene expression (GO:0023019)2.70749845
176regulation of long-term neuronal synaptic plasticity (GO:0048169)2.69347120
177cellular potassium ion homeostasis (GO:0030007)2.69042547
178regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.68548065
179diterpenoid biosynthetic process (GO:0016102)2.68272770
180neurotransmitter biosynthetic process (GO:0042136)2.68209529
181organelle transport along microtubule (GO:0072384)2.68179266
182centriole replication (GO:0007099)2.66374429
183membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.66210227
184regulation of glutamate secretion (GO:0014048)2.65680688
185regulation of epithelial cell differentiation involved in kidney development (GO:2000696)2.65396587
186lung epithelium development (GO:0060428)2.64760174
187glycosylceramide metabolic process (GO:0006677)2.64634802
188positive regulation of dendritic spine development (GO:0060999)2.64025804
189cellular response to ethanol (GO:0071361)2.63909736
190negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.63887067
191lung-associated mesenchyme development (GO:0060484)2.63505943
192regulation of myelination (GO:0031641)2.63432991
193drug transmembrane transport (GO:0006855)2.63389241
194flavonoid metabolic process (GO:0009812)2.62959158
195regulation of pigment cell differentiation (GO:0050932)2.57635545
196regulation of mesenchymal cell apoptotic process (GO:2001053)2.56653502

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.05779960
2FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse5.03069294
3HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse4.82758354
4KLF2_18264089_ChIP-ChIP_MESCs_Mouse3.81779611
5KLF5_18264089_ChIP-ChIP_MESCs_Mouse3.81779611
6KLF4_18264089_ChIP-ChIP_MESCs_Mouse3.81779611
7FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human3.46271094
8GBX2_23144817_ChIP-Seq_PC3_Human3.16195540
9AR_21572438_ChIP-Seq_LNCaP_Human3.00873777
10TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.90622936
11JARID2_20064375_ChIP-Seq_MESCs_Mouse2.82302993
12FOXO3_23340844_ChIP-Seq_DLD1_Human2.81036369
13SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.76936527
14EZH2_18974828_ChIP-Seq_MESCs_Mouse2.71941566
15RNF2_18974828_ChIP-Seq_MESCs_Mouse2.71941566
16SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.70244857
17SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.61090025
18EZH2_27304074_Chip-Seq_ESCs_Mouse2.53728166
19TAF15_26573619_Chip-Seq_HEK293_Human2.43225768
20SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.41280910
21SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.40704225
22DROSHA_22980978_ChIP-Seq_HELA_Human2.39817191
23JARID2_20075857_ChIP-Seq_MESCs_Mouse2.39127126
24SRY_22984422_ChIP-ChIP_TESTIS_Rat2.25306858
25ESR1_21235772_ChIP-Seq_MCF-7_Human2.24418823
26SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.24362799
27SUZ12_27294783_Chip-Seq_ESCs_Mouse2.23564600
28RNF2_27304074_Chip-Seq_ESCs_Mouse2.22261784
29MTF2_20144788_ChIP-Seq_MESCs_Mouse2.21385676
30SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.17040140
31SOX2_27498859_Chip-Seq_STOMACH_Mouse2.16660114
32GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.12473982
33TP63_17297297_ChIP-ChIP_HaCaT_Human2.05087814
34STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.04266175
35* EED_16625203_ChIP-ChIP_MESCs_Mouse1.97467794
36REST_21632747_ChIP-Seq_MESCs_Mouse1.96196002
37ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.86082519
38EZH2_27294783_Chip-Seq_ESCs_Mouse1.83459428
39RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.80715050
40GATA4_25053715_ChIP-Seq_YYC3_Human1.80055564
41RARB_27405468_Chip-Seq_BRAIN_Mouse1.79737234
42ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.79623336
43SOX2_20726797_ChIP-Seq_SW620_Human1.77837767
44CTBP1_25329375_ChIP-Seq_LNCAP_Human1.68197934
45TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.67820975
46ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.67573575
47BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.60883734
48EGR1_19032775_ChIP-ChIP_M12_Human1.59892109
49REST_18959480_ChIP-ChIP_MESCs_Mouse1.58528895
50RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.58296587
51CBX2_27304074_Chip-Seq_ESCs_Mouse1.57527218
52TRIM28_21343339_ChIP-Seq_HEK293_Human1.55262436
53BMI1_23680149_ChIP-Seq_NPCS_Mouse1.49227353
54SMAD_19615063_ChIP-ChIP_OVARY_Human1.48425062
55BCAT_22108803_ChIP-Seq_LS180_Human1.48340888
56EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.47024235
57TCF4_18268006_ChIP-ChIP_LS174T_Human1.44630139
58RING1B_27294783_Chip-Seq_ESCs_Mouse1.43723206
59IKZF1_21737484_ChIP-ChIP_HCT116_Human1.43028551
60ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.41024112
61CDX2_22108803_ChIP-Seq_LS180_Human1.40385083
62GATA1_26923725_Chip-Seq_HPCs_Mouse1.39576801
63ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.39152095
64FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.36814830
65PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.35905345
66GATA6_25053715_ChIP-Seq_YYC3_Human1.35027831
67EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.34913280
68MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.34495579
69RNF2_27304074_Chip-Seq_NSC_Mouse1.31832403
70NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.31737596
71VDR_22108803_ChIP-Seq_LS180_Human1.31248095
72CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.30460222
73SMAD3_21741376_ChIP-Seq_EPCs_Human1.30388169
74PCGF2_27294783_Chip-Seq_NPCs_Mouse1.29917538
75WT1_19549856_ChIP-ChIP_CCG9911_Human1.29634414
76P300_19829295_ChIP-Seq_ESCs_Human1.29373714
77ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.28445562
78TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.27720715
79CDX2_20551321_ChIP-Seq_CACO-2_Human1.26150735
80GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.25210415
81CTBP2_25329375_ChIP-Seq_LNCAP_Human1.24703910
82KLF5_25053715_ChIP-Seq_YYC3_Human1.23210181
83AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.20710089
84GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.20560139
85PIAS1_25552417_ChIP-Seq_VCAP_Human1.19909648
86LXR_22158963_ChIP-Seq_LIVER_Mouse1.18448234
87SMAD4_21799915_ChIP-Seq_A2780_Human1.18189715
88NR3C1_23031785_ChIP-Seq_PC12_Mouse1.17926189
89CDX2_19796622_ChIP-Seq_MESCs_Mouse1.17754795
90RXR_22158963_ChIP-Seq_LIVER_Mouse1.15131897
91IRF8_22096565_ChIP-ChIP_GC-B_Human1.14659205
92POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.13017810
93PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.11723326
94THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.11230056
95FOXM1_26456572_ChIP-Seq_MCF-7_Human1.11086460
96CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.11086137
97BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.10747646
98SMAD4_21741376_ChIP-Seq_HESCs_Human1.08366104
99FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.08321812
100STAT1_20625510_ChIP-Seq_HELA_Human1.07470171
101CTCF_27219007_Chip-Seq_Bcells_Human1.07157976
102TOP2B_26459242_ChIP-Seq_MCF-7_Human1.06733970
103* RING1B_27294783_Chip-Seq_NPCs_Mouse1.06586488
104ERG_21242973_ChIP-ChIP_JURKAT_Human1.05592982
105SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.04329265
106ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.04287246
107NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.03894273
108P53_22127205_ChIP-Seq_FIBROBLAST_Human1.03000809
109PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.02421880
110NR3C1_21868756_ChIP-Seq_MCF10A_Human1.01695312
111SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.01415920
112RUNX1_27514584_Chip-Seq_MCF-7_Human1.00962534
113SMAD3_21741376_ChIP-Seq_HESCs_Human1.00814945
114AR_25329375_ChIP-Seq_VCAP_Human1.00208265
115KDM2B_26808549_Chip-Seq_K562_Human0.99767666
116AHR_22903824_ChIP-Seq_MCF-7_Human0.98839187
117FOXA1_25552417_ChIP-Seq_VCAP_Human0.98606669
118OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.98594335
119ZNF263_19887448_ChIP-Seq_K562_Human0.98370531
120CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.96446826
121SOX2_21211035_ChIP-Seq_LN229_Gbm0.96393168
122ESR2_21235772_ChIP-Seq_MCF-7_Human0.95785465
123ZFP57_27257070_Chip-Seq_ESCs_Mouse0.95288347
124GATA3_24758297_ChIP-Seq_MCF-7_Human0.95078076
125STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.94684051
126PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.93764072
127SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.93571679
128CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.92807239
129WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.92606396
130GATA1_19941826_ChIP-Seq_K562_Human0.92275352
131EGR1_23403033_ChIP-Seq_LIVER_Mouse0.91893230
132CEBPB_22108803_ChIP-Seq_LS180_Human0.91753765
133SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.91727557
134BP1_19119308_ChIP-ChIP_Hs578T_Human0.90288403
135RXR_22108803_ChIP-Seq_LS180_Human0.90220602
136KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.90202420
137POU3F2_20337985_ChIP-ChIP_501MEL_Human0.90032977
138RUNX2_22187159_ChIP-Seq_PCA_Human0.89703800
139* RBPJ_21746931_ChIP-Seq_IB4_Human0.89239460
140FUS_26573619_Chip-Seq_HEK293_Human0.89031208
141KDM2B_26808549_Chip-Seq_REH_Human0.88957904
142TP53_20018659_ChIP-ChIP_R1E_Mouse0.87679488
143DNAJC2_21179169_ChIP-ChIP_NT2_Human0.87268856
144PPARA_22158963_ChIP-Seq_LIVER_Mouse0.86200728
145P53_22387025_ChIP-Seq_ESCs_Mouse0.85502132
146ARNT_22903824_ChIP-Seq_MCF-7_Human0.85255967
147TCF4_22108803_ChIP-Seq_LS180_Human0.84677818
148NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.84394979
149CREB1_26743006_Chip-Seq_LNCaP_Human0.84305516
150KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.84004772
151STAT6_21828071_ChIP-Seq_BEAS2B_Human0.83780986
152ESRRB_18555785_Chip-Seq_ESCs_Mouse0.83009480
153SMAD4_21741376_ChIP-Seq_EPCs_Human0.82841566
154ZNF217_24962896_ChIP-Seq_MCF-7_Human0.82750308
155AR_19668381_ChIP-Seq_PC3_Human0.82227861
156CSB_26484114_Chip-Seq_FIBROBLAST_Human0.81385681
157CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.80962620
158NANOG_18555785_Chip-Seq_ESCs_Mouse0.80525262
159SUZ12_18555785_Chip-Seq_ESCs_Mouse0.80265628
160YAP1_20516196_ChIP-Seq_MESCs_Mouse0.79126591
161STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.78395697
162STAT3_18555785_Chip-Seq_ESCs_Mouse0.77183619
163IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.77160382
164TCF3_18692474_ChIP-Seq_MEFs_Mouse0.77077237
165ZNF274_21170338_ChIP-Seq_K562_Hela0.76753398
166JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.76247556
167ESR1_20079471_ChIP-ChIP_T-47D_Human0.74913185
168PPAR_26484153_Chip-Seq_NCI-H1993_Human0.74317432
169GATA2_19941826_ChIP-Seq_K562_Human0.74085053
170P53_21459846_ChIP-Seq_SAOS-2_Human0.72859659
171AR_21909140_ChIP-Seq_LNCAP_Human0.72802931
172STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.72726997

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system6.22417511
2MP0003136_yellow_coat_color4.71634179
3MP0002653_abnormal_ependyma_morphology4.58202411
4MP0002138_abnormal_hepatobiliary_system4.22946159
5MP0004133_heterotaxia4.22299420
6MP0009379_abnormal_foot_pigmentation3.99476700
7MP0004859_abnormal_synaptic_plasticity3.84755653
8MP0003880_abnormal_central_pattern3.80542305
9MP0003183_abnormal_peptide_metabolism3.28703412
10MP0003635_abnormal_synaptic_transmissio3.18949306
11MP0001984_abnormal_olfaction3.18331876
12MP0002822_catalepsy3.11563342
13MP0004264_abnormal_extraembryonic_tissu2.83130578
14MP0009745_abnormal_behavioral_response2.80923827
15MP0004270_analgesia2.73071133
16MP0002132_abnormal_respiratory_system2.72724979
17MP0005085_abnormal_gallbladder_physiolo2.71115764
18MP0002063_abnormal_learning/memory/cond2.68813055
19MP0002064_seizures2.62543099
20MP0002837_dystrophic_cardiac_calcinosis2.52638065
21MP0005670_abnormal_white_adipose2.44188706
22MP0009780_abnormal_chondrocyte_physiolo2.42184159
23MP0005365_abnormal_bile_salt2.40612637
24MP0009046_muscle_twitch2.40553509
25MP0001440_abnormal_grooming_behavior2.38276863
26MP0004147_increased_porphyrin_level2.34372320
27MP0002572_abnormal_emotion/affect_behav2.33669841
28MP0005187_abnormal_penis_morphology2.12340765
29MP0000566_synostosis2.11947716
30MP0002272_abnormal_nervous_system2.11041050
31MP0001486_abnormal_startle_reflex2.04726392
32MP0001663_abnormal_digestive_system1.98414317
33MP0002876_abnormal_thyroid_physiology1.98326237
34MP0001968_abnormal_touch/_nociception1.97562712
35MP0003303_peritoneal_inflammation1.96084529
36MP0004272_abnormal_basement_membrane1.95437259
37MP0003866_abnormal_defecation1.91974964
38MP0010234_abnormal_vibrissa_follicle1.91124010
39MP0001485_abnormal_pinna_reflex1.88859432
40MP0002736_abnormal_nociception_after1.88484069
41MP0010386_abnormal_urinary_bladder1.86241075
42MP0009785_altered_susceptibility_to1.80051258
43MP0002184_abnormal_innervation1.79077115
44MP0001873_stomach_inflammation1.76454127
45MP0000013_abnormal_adipose_tissue1.74629790
46MP0001501_abnormal_sleep_pattern1.74609363
47MP0000465_gastrointestinal_hemorrhage1.74137111
48MP0000490_abnormal_crypts_of1.73240250
49MP0010155_abnormal_intestine_physiology1.71566754
50MP0002557_abnormal_social/conspecific_i1.69517589
51MP0000778_abnormal_nervous_system1.61964061
52MP0000681_abnormal_thyroid_gland1.57771197
53MP0004142_abnormal_muscle_tone1.56330492
54MP0004484_altered_response_of1.54766594
55MP0005645_abnormal_hypothalamus_physiol1.53593183
56MP0002734_abnormal_mechanical_nocicepti1.52852445
57MP0002163_abnormal_gland_morphology1.51307227
58MP0000678_abnormal_parathyroid_gland1.50864864
59MP0005381_digestive/alimentary_phenotyp1.50415807
60MP0004043_abnormal_pH_regulation1.48661994
61MP0003329_amyloid_beta_deposits1.47211222
62MP0005023_abnormal_wound_healing1.45685982
63MP0005551_abnormal_eye_electrophysiolog1.41990718
64MP0003252_abnormal_bile_duct1.41526222
65MP0002067_abnormal_sensory_capabilities1.40696842
66MP0002909_abnormal_adrenal_gland1.39581546
67MP0003283_abnormal_digestive_organ1.39502446
68MP0005084_abnormal_gallbladder_morpholo1.36693060
69MP0002009_preneoplasia1.36671393
70MP0001188_hyperpigmentation1.35571210
71MP0001970_abnormal_pain_threshold1.33430092
72MP0010352_gastrointestinal_tract_polyps1.31846941
73MP0002735_abnormal_chemical_nociception1.30919143
74MP0005025_abnormal_response_to1.29183843
75MP0005409_darkened_coat_color1.29108732
76MP0006276_abnormal_autonomic_nervous1.28921487
77MP0001664_abnormal_digestion1.27805415
78MP0002733_abnormal_thermal_nociception1.27287935
79MP0001765_abnormal_ion_homeostasis1.24516239
80MP0000537_abnormal_urethra_morphology1.23487000
81MP0005076_abnormal_cell_differentiation1.23053887
82MP0003633_abnormal_nervous_system1.22387854
83MP0002796_impaired_skin_barrier1.21903187
84MP0000639_abnormal_adrenal_gland1.17951391
85MP0003950_abnormal_plasma_membrane1.17366636
86MP0004858_abnormal_nervous_system1.16340043
87MP0001790_abnormal_immune_system1.16206719
88MP0005387_immune_system_phenotype1.16206719
89MP0008004_abnormal_stomach_pH1.14873353
90MP0000372_irregular_coat_pigmentation1.14544139
91MP0009765_abnormal_xenobiotic_induced1.14168853
92MP0000751_myopathy1.13933289
93MP0005451_abnormal_body_composition1.12944200
94MP0001764_abnormal_homeostasis1.12269327
95MP0008569_lethality_at_weaning1.11654465
96MP0003724_increased_susceptibility_to1.10450603
97MP0003879_abnormal_hair_cell1.09645206
98MP0001529_abnormal_vocalization1.08644752
99MP0008875_abnormal_xenobiotic_pharmacok1.07326750
100MP0005423_abnormal_somatic_nervous1.07162173
101MP0001851_eye_inflammation1.06679983
102MP0002229_neurodegeneration1.06218042
103MP0002882_abnormal_neuron_morphology1.06161468
104MP0001905_abnormal_dopamine_level1.05298320
105MP0005257_abnormal_intraocular_pressure1.04285407
106MP0004924_abnormal_behavior1.02638751
107MP0005386_behavior/neurological_phenoty1.02638751
108MP0002998_abnormal_bone_remodeling1.00399992
109MP0004130_abnormal_muscle_cell0.97013636
110MP0003868_abnormal_feces_composition0.96772363
111MP0004145_abnormal_muscle_electrophysio0.96680165
112MP0005310_abnormal_salivary_gland0.95843274
113MP0005058_abnormal_lysosome_morphology0.95768020
114MP0003122_maternal_imprinting0.95753541
115MP0002136_abnormal_kidney_physiology0.95221456
116MP0002277_abnormal_respiratory_mucosa0.94595690
117MP0000955_abnormal_spinal_cord0.92731732
118MP0004811_abnormal_neuron_physiology0.90077123
119MP0002896_abnormal_bone_mineralization0.89293879
120MP0002066_abnormal_motor_capabilities/c0.89134900
121MP0003631_nervous_system_phenotype0.89091346
122MP0001849_ear_inflammation0.85622077
123MP0006072_abnormal_retinal_apoptosis0.85452822
124MP0004782_abnormal_surfactant_physiolog0.85397820
125MP0003632_abnormal_nervous_system0.82169643
126MP0000230_abnormal_systemic_arterial0.80888367
127MP0008872_abnormal_physiological_respon0.79106479
128MP0005595_abnormal_vascular_smooth0.77251597
129MP0002282_abnormal_trachea_morphology0.76298725
130MP0005379_endocrine/exocrine_gland_phen0.76261732
131MP0001919_abnormal_reproductive_system0.74081463
132MP0002152_abnormal_brain_morphology0.72997842
133MP0005166_decreased_susceptibility_to0.72878744
134MP0001502_abnormal_circadian_rhythm0.71325368
135MP0005167_abnormal_blood-brain_barrier0.70842680
136MP0002069_abnormal_eating/drinking_beha0.70287441
137MP0004885_abnormal_endolymph0.69843637
138MP0001963_abnormal_hearing_physiology0.69233844
139MP0000604_amyloidosis0.68972254
140MP0003137_abnormal_impulse_conducting0.68714258
141MP0004947_skin_inflammation0.68709313
142MP0002166_altered_tumor_susceptibility0.68436365
143MP0003938_abnormal_ear_development0.68160046
144MP0005623_abnormal_meninges_morphology0.68003505
145MP0001800_abnormal_humoral_immune0.67060098
146MP0003045_fibrosis0.67041188
147MP0006054_spinal_hemorrhage0.66408919
148MP0002098_abnormal_vibrissa_morphology0.65883007
149MP0000631_abnormal_neuroendocrine_gland0.64944238
150MP0005636_abnormal_mineral_homeostasis0.64886642
151MP0000467_abnormal_esophagus_morphology0.64415792
152MP0001845_abnormal_inflammatory_respons0.64393818
153MP0003795_abnormal_bone_structure0.63582107
154MP0001666_abnormal_nutrient_absorption0.63189875
155MP0003943_abnormal_hepatobiliary_system0.62959381
156MP0009643_abnormal_urine_homeostasis0.62863172
157MP0000477_abnormal_intestine_morphology0.62533750
158MP0001944_abnormal_pancreas_morphology0.62305034
159MP0000538_abnormal_urinary_bladder0.61878036
160MP0001533_abnormal_skeleton_physiology0.58602950
161MP0005389_reproductive_system_phenotype0.58269673
162MP0003300_gastrointestinal_ulcer0.56207602
163MP0002452_abnormal_antigen_presenting0.56033460
164MP0004019_abnormal_vitamin_homeostasis0.55167178
165MP0003953_abnormal_hormone_level0.53856594
166MP0000049_abnormal_middle_ear0.53837808
167MP0004510_myositis0.53480380
168MP0005464_abnormal_platelet_physiology0.51449154
169MP0001756_abnormal_urination0.49130939

Predicted human phenotypes

RankGene SetZ-score
1Flat acetabular roof (HP:0003180)6.65416794
2Neonatal short-limb short stature (HP:0008921)6.19988136
3Abnormality of chloride homeostasis (HP:0011422)5.18141832
4Focal motor seizures (HP:0011153)5.02080866
5Flat capital femoral epiphysis (HP:0003370)4.88560271
6Hyperactive renin-angiotensin system (HP:0000841)4.79431388
7Abnormality of the lower motor neuron (HP:0002366)4.65849358
8Hyperthyroidism (HP:0000836)4.63104889
9Intellectual disability, moderate (HP:0002342)4.61328489
10Flattened epiphyses (HP:0003071)4.52514080
11Abdominal distention (HP:0003270)4.42316391
12Visceral angiomatosis (HP:0100761)4.35219333
13Breech presentation (HP:0001623)4.28827260
14Metabolic alkalosis (HP:0200114)4.12759881
15Hoarse voice (HP:0001609)4.01903483
16Atonic seizures (HP:0010819)3.94046433
17Hyponatremia (HP:0002902)3.93762891
18Irregular epiphyses (HP:0010582)3.91837859
19Abnormality of the distal phalanx of the thumb (HP:0009617)3.88489768
20Abnormal ciliary motility (HP:0012262)3.88465935
21Hemangiomatosis (HP:0007461)3.87651036
22Right ventricular cardiomyopathy (HP:0011663)3.86268625
23Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.81121306
24Ankle contracture (HP:0006466)3.78526473
25Abnormal hair whorl (HP:0010721)3.73169084
26Spinal cord compression (HP:0002176)3.68388958
27Abnormal respiratory motile cilium morphology (HP:0005938)3.65027190
28Abnormal respiratory epithelium morphology (HP:0012253)3.65027190
29Focal seizures (HP:0007359)3.57484746
30Visual hallucinations (HP:0002367)3.57304950
31Symphalangism affecting the phalanges of the hand (HP:0009773)3.45843283
32Abnormal cartilage morphology (HP:0002763)3.43312289
33Conjugated hyperbilirubinemia (HP:0002908)3.39622787
34Impulsivity (HP:0100710)3.29212813
35Esophageal atresia (HP:0002032)3.27318284
36Abnormality of monocarboxylic acid metabolism (HP:0010996)3.23778868
37Abnormal vertebral ossification (HP:0100569)3.17413766
38Amyotrophic lateral sclerosis (HP:0007354)3.16419015
39Aplasia/Hypoplasia of the vertebrae (HP:0008515)3.06539412
40Vertebral hypoplasia (HP:0008417)3.06539412
41Intrahepatic cholestasis (HP:0001406)3.04049234
42Broad-based gait (HP:0002136)3.03482347
43Testicular atrophy (HP:0000029)3.03231043
44Rhinitis (HP:0012384)3.02952813
45Occipital encephalocele (HP:0002085)3.02677184
46Abnormality of renin-angiotensin system (HP:0000847)3.02529779
47Abnormality of sodium homeostasis (HP:0010931)3.02486416
48True hermaphroditism (HP:0010459)3.01578449
49Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)2.99227700
50Abnormal respiratory motile cilium physiology (HP:0012261)2.97043249
51Vertebral clefting (HP:0008428)2.96295450
52Hip contracture (HP:0003273)2.94676486
53Large earlobe (HP:0009748)2.92875975
54Epileptic encephalopathy (HP:0200134)2.88132054
55Hypokalemia (HP:0002900)2.85173837
56Cerebral inclusion bodies (HP:0100314)2.83758183
57Hyperventilation (HP:0002883)2.82115920
58Spontaneous abortion (HP:0005268)2.81727581
59Seborrheic dermatitis (HP:0001051)2.81090543
60Adrenal overactivity (HP:0002717)2.78817275
61Hypoplasia of the thymus (HP:0000778)2.72701362
62Septate vagina (HP:0001153)2.71894829
63Decreased circulating renin level (HP:0003351)2.68686626
64Short middle phalanx of finger (HP:0005819)2.67737086
65Stillbirth (HP:0003826)2.67058817
66Abnormal biliary tract morphology (HP:0012440)2.66596280
67Choroideremia (HP:0001139)2.66029537
68Cerebral hypomyelination (HP:0006808)2.64492204
69Abnormality of potassium homeostasis (HP:0011042)2.61492775
70Dynein arm defect of respiratory motile cilia (HP:0012255)2.60552190
71Absent/shortened dynein arms (HP:0200106)2.60552190
72Absence seizures (HP:0002121)2.60444050
73Dialeptic seizures (HP:0011146)2.52586472
74Cone-rod dystrophy (HP:0000548)2.45478102
75Overfolded helix (HP:0000396)2.41794768
76Myokymia (HP:0002411)2.40619910
77Delusions (HP:0000746)2.40322498
78Aplasia/hypoplasia of the femur (HP:0005613)2.38947801
79Submucous cleft hard palate (HP:0000176)2.36884147
80Pancreatic fibrosis (HP:0100732)2.36633389
81Spastic diplegia (HP:0001264)2.35687140
82Prominent nose (HP:0000448)2.35105791
83Cerebral palsy (HP:0100021)2.33945520
84Oligodactyly (hands) (HP:0001180)2.31990802
85Sclerocornea (HP:0000647)2.31476816
86Pointed chin (HP:0000307)2.31009043
87Hip dysplasia (HP:0001385)2.30049651
88Hyperkalemia (HP:0002153)2.29595508
89Progressive visual loss (HP:0000529)2.28320311
90Lip pit (HP:0100267)2.27364056
91Broad face (HP:0000283)2.27124034
92Abnormal foot bone ossification (HP:0010675)2.26986706
93Limited elbow extension (HP:0001377)2.25734488
94Thyroid-stimulating hormone excess (HP:0002925)2.23720106
95Hyperaldosteronism (HP:0000859)2.22898790
96Abnormality of the dental root (HP:0006486)2.22853603
97Taurodontia (HP:0000679)2.22853603
98Abnormality of permanent molar morphology (HP:0011071)2.22853603
99Calf muscle hypertrophy (HP:0008981)2.21795342
100Short tibia (HP:0005736)2.21307180
101Abnormal delivery (HP:0001787)2.18991838
102Atelectasis (HP:0100750)2.18889304
103Limited hip movement (HP:0008800)2.18706884
104Abnormally folded helix (HP:0008544)2.17890191
105Congenital stationary night blindness (HP:0007642)2.17869233
106Abnormal tarsal ossification (HP:0008369)2.17565505
107Neurofibrillary tangles (HP:0002185)2.17231610
108Abnormality of molar (HP:0011077)2.13478516
109Abnormality of molar morphology (HP:0011070)2.13478516
110Syncope (HP:0001279)2.13359472
111Progressive sensorineural hearing impairment (HP:0000408)2.12899909
112Alkalosis (HP:0001948)2.12467382
113Febrile seizures (HP:0002373)2.11440198
114Generalized tonic-clonic seizures (HP:0002069)2.10057306
115Proximal placement of thumb (HP:0009623)2.09848460
116Abnormality of the nasal septum (HP:0000419)2.09657015
117Vacuolated lymphocytes (HP:0001922)2.08029246
118Protuberant abdomen (HP:0001538)2.05814622
119Aplasia/Hypoplasia of the earlobes (HP:0009906)2.04074492
120Abnormality of the dental pulp (HP:0006479)2.03992481
121Focal segmental glomerulosclerosis (HP:0000097)2.03931523
122Intention tremor (HP:0002080)2.03752250
123Diplopia (HP:0000651)2.02688902
124Abnormality of binocular vision (HP:0011514)2.02688902
125Hyperphosphatemia (HP:0002905)2.02181857
126Abnormality of magnesium homeostasis (HP:0004921)1.98899912
127Ileus (HP:0002595)1.98298246
128Renal dysplasia (HP:0000110)1.97532510
129Abnormal social behavior (HP:0012433)1.97268140
130Impaired social interactions (HP:0000735)1.97268140
131Excessive salivation (HP:0003781)1.97069346
132Drooling (HP:0002307)1.97069346
133Epileptiform EEG discharges (HP:0011182)1.96513846
134Craniofacial dystonia (HP:0012179)1.96508661
135Sensorimotor neuropathy (HP:0007141)1.95733517
136Premature loss of primary teeth (HP:0006323)1.93993413
137Hypertensive crisis (HP:0100735)1.92752495
138Truncus arteriosus (HP:0001660)1.92252633
139Azoospermia (HP:0000027)1.91596387
140Partial duplication of thumb phalanx (HP:0009944)1.91406708
141Hemiparesis (HP:0001269)1.91200317
142Deviation of the thumb (HP:0009603)1.90899013
143Abnormality of aromatic amino acid family metabolism (HP:0004338)1.89649269
144Oligodontia (HP:0000677)1.89589651
145Congenital sensorineural hearing impairment (HP:0008527)1.89397382
146Abnormality of the nasal mucosa (HP:0000433)1.88927042
147Medulloblastoma (HP:0002885)1.87497810
148Conjunctival telangiectasia (HP:0000524)1.87368003
149Muscle hypertrophy of the lower extremities (HP:0008968)1.87128781
150Villous atrophy (HP:0011473)1.85983976
151Abnormality of small intestinal villus morphology (HP:0011472)1.85983976
152Oculomotor apraxia (HP:0000657)1.85805681
153Patellar aplasia (HP:0006443)1.85170707
154Abnormal eating behavior (HP:0100738)1.84623037
155Aplasia/Hypoplasia of the patella (HP:0006498)1.84348709
156Bony spicule pigmentary retinopathy (HP:0007737)1.84147700
157Horizontal nystagmus (HP:0000666)1.83989136
158Chorioretinal atrophy (HP:0000533)1.83792571
159Abnormality of the intervertebral disk (HP:0005108)1.83695578
160Abnormality of the tricuspid valve (HP:0001702)1.83434325
161Anxiety (HP:0000739)1.83356864
162Cystic hygroma (HP:0000476)1.82605724
163Hypothermia (HP:0002045)1.82341860
164Decreased central vision (HP:0007663)1.81607729
165Short philtrum (HP:0000322)1.81056777
166EEG with generalized epileptiform discharges (HP:0011198)1.80545105
167Focal dystonia (HP:0004373)1.79845197
168Short thorax (HP:0010306)1.79759887
169Nasal polyposis (HP:0100582)1.79102044
1703-Methylglutaconic aciduria (HP:0003535)1.77958365
171Hypoplasia of the uterus (HP:0000013)1.77843813
172Spontaneous hematomas (HP:0007420)1.77133691
173Severe visual impairment (HP:0001141)1.76351360
174Slow-growing hair (HP:0002217)1.76088080
175Abnormality of hair growth rate (HP:0011363)1.76088080
176Poor eye contact (HP:0000817)1.75633100
177Abnormality of carpal bone ossification (HP:0006257)1.75416477
178Fair hair (HP:0002286)1.74806105
179Long face (HP:0000276)1.74654962
180Aplasia/Hypoplasia of the middle phalanges of the hand (HP:0009843)1.74357815
181Dehydration (HP:0001944)1.74230515
182Scanning speech (HP:0002168)1.73935140
183Spastic tetraparesis (HP:0001285)1.73161403
184Interstitial pulmonary disease (HP:0006530)1.71115292
185Abnormality of the acetabulum (HP:0003170)1.69610461
186Osteoarthritis (HP:0002758)1.67926752
187Conical tooth (HP:0000698)1.67402841
188Biliary tract neoplasm (HP:0100574)1.66783991
189Hypoplastic ilia (HP:0000946)1.65323593

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA25.89631298
2CAMKK24.37693323
3ACVR1B4.28037616
4TYRO33.70726604
5PLK23.63451025
6BRSK23.44684544
7STK393.36331149
8PHKG12.89506640
9PHKG22.89506640
10MAPK152.87834861
11CASK2.86068149
12NTRK32.73704499
13PLK42.70177923
14TLK12.51228955
15CAMKK12.47382003
16MINK12.43952128
17PDK22.37611464
18NTRK12.09541549
19RIPK12.04398882
20PIK3CA2.00987475
21RIPK41.79579175
22EPHA41.74169863
23TRIB31.73730033
24CAMK2B1.73219834
25MST41.70677468
26MET1.68714493
27TESK11.54794971
28FGFR31.53566656
29MKNK21.52438899
30ABL21.47431064
31PTK61.46233370
32EPHB21.46090812
33MST1R1.43933660
34MATK1.42862057
35TAOK31.40272756
36STK38L1.39098869
37FER1.38467022
38BRSK11.36377380
39GRK61.35152244
40MYLK1.33900637
41PNCK1.33456962
42DAPK21.32317206
43STK161.29023584
44DAPK11.22441244
45MAP3K141.22261674
46PKN21.20596243
47FGR1.14898555
48EPHB11.14625178
49LMTK21.14257315
50GRK11.12905288
51CAMK2A1.10400611
52MAP3K21.08810599
53LIMK11.07779757
54WNK41.05227408
55LATS11.04016218
56SIK20.97576095
57CDK50.96776823
58TESK20.96204797
59PRKG20.96106396
60CSNK1A1L0.95535821
61PRKCG0.94988015
62GRK50.94586706
63NEK60.92741578
64ALK0.91014832
65FES0.90663654
66CSK0.89316191
67CAMK2D0.83025864
68PTK2B0.82568370
69CSNK1G30.81474479
70PRKCQ0.80955259
71STK240.77461940
72NLK0.77304191
73PTK20.76996867
74MAP3K100.76597977
75CSNK1G20.76424143
76FGFR40.76031163
77BMX0.75452442
78MAP2K60.75157134
79UHMK10.74084111
80MARK10.72775377
81NME10.72661776
82IRAK20.72427948
83LRRK20.71120324
84MAPK130.69363702
85EEF2K0.68312952
86MAPKAPK30.68192429
87ZAP700.67284381
88BCR0.66193664
89CSNK1E0.64102466
90CAMK2G0.64044074
91JAK10.63271803
92CAMK40.62456069
93CDK190.61500618
94PRKCH0.60521410
95PRKCI0.59895702
96CSNK1G10.58901984
97PDGFRA0.58715397
98MAP3K90.58370407
99MAP3K40.57295899
100PKN10.55717006
101NEK10.55407397
102INSRR0.54443178
103PDPK10.53784585
104STK380.51362873
105PDGFRB0.51330350
106MAPKAPK20.51230221
107SGK2230.51082826
108SGK4940.51082826
109BMPR20.50692510
110MAP2K40.49789009
111ERBB20.49373888
112MAP3K120.49309818
113FRK0.49222451
114MKNK10.48959057
115SGK20.46413632
116PDK10.46339669
117PDK40.45978399
118PDK30.45978399
119RPS6KB20.42969181
120IRAK10.42030338
121YES10.41467055
122MAP2K70.41080608
123EPHA30.40729808
124DMPK0.40507454
125PRKCA0.40458335
126ADRBK20.40441117
127PRKCD0.39086578
128DDR20.38693782
129TTK0.38426265
130ADRBK10.38278037
131CDK140.38175288
132MAP3K60.37194049
133FGFR20.37186857
134KSR20.37106615
135TRPM70.36905592
136ERBB30.36772830
137BMPR1B0.36544353
138PRKAA20.35798763
139PRKACB0.35207326
140TGFBR20.34542331
141IGF1R0.34295416
142SRC0.34242053
143PRKCB0.33788153
144OXSR10.33293167
145MAP3K130.33193109
146PRKCZ0.32925752
147NTRK20.32613948
148PRKAA10.31935414
149AKT30.31928260
150FGFR10.31831061
151INSR0.31507008
152PRKCE0.31506272
153TXK0.30992311
154CLK10.30909479
155ERN10.30748492
156TBK10.30437643
157JAK20.29466522
158PRKD20.27350154
159MAP2K20.27241710
160PRKACG0.25669748
161PRKD10.23908921
162MAPK40.23855397
163PRKACA0.22819803
164CDC42BPA0.21253032
165IRAK30.19355202
166PRKG10.18680660
167MAP3K10.17529984
168LYN0.17296471
169VRK10.16916553

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009106.55000343
2Taurine and hypotaurine metabolism_Homo sapiens_hsa004303.78186129
3Cyanoamino acid metabolism_Homo sapiens_hsa004603.30449126
4Olfactory transduction_Homo sapiens_hsa047403.20188845
5Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.76074572
6Nicotine addiction_Homo sapiens_hsa050332.63798611
7Phototransduction_Homo sapiens_hsa047442.58893099
8Histidine metabolism_Homo sapiens_hsa003402.36982323
9Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005122.32825643
10Long-term potentiation_Homo sapiens_hsa047202.32252935
11Glutamatergic synapse_Homo sapiens_hsa047242.26167019
12Renin secretion_Homo sapiens_hsa049242.20196238
13Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.17207362
14Caffeine metabolism_Homo sapiens_hsa002322.14156660
15GABAergic synapse_Homo sapiens_hsa047272.13582294
16Pentose and glucuronate interconversions_Homo sapiens_hsa000402.05118046
17Morphine addiction_Homo sapiens_hsa050322.00707617
18Circadian entrainment_Homo sapiens_hsa047131.97383901
19Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.91029445
20Taste transduction_Homo sapiens_hsa047421.87585039
21Salivary secretion_Homo sapiens_hsa049701.79357737
22Synaptic vesicle cycle_Homo sapiens_hsa047211.78156881
23Amphetamine addiction_Homo sapiens_hsa050311.73120549
24Intestinal immune network for IgA production_Homo sapiens_hsa046721.70931823
25Dopaminergic synapse_Homo sapiens_hsa047281.60753986
26Sphingolipid metabolism_Homo sapiens_hsa006001.60559444
27Other glycan degradation_Homo sapiens_hsa005111.60477976
28Melanogenesis_Homo sapiens_hsa049161.59945289
29Gastric acid secretion_Homo sapiens_hsa049711.56772840
30Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.56666766
31Insulin secretion_Homo sapiens_hsa049111.54733158
32Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.53289853
33Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.52801499
34Collecting duct acid secretion_Homo sapiens_hsa049661.49019257
35Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.47540736
36Retinol metabolism_Homo sapiens_hsa008301.45834694
37Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.40939941
38Cholinergic synapse_Homo sapiens_hsa047251.40466045
39Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.39751034
40Oxytocin signaling pathway_Homo sapiens_hsa049211.38603998
41Long-term depression_Homo sapiens_hsa047301.37478958
42Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.37359196
43Fatty acid degradation_Homo sapiens_hsa000711.35623202
44Serotonergic synapse_Homo sapiens_hsa047261.33617599
45Aldosterone synthesis and secretion_Homo sapiens_hsa049251.32869511
46Calcium signaling pathway_Homo sapiens_hsa040201.29132422
47Leukocyte transendothelial migration_Homo sapiens_hsa046701.28237863
48Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.28178043
49Glycerolipid metabolism_Homo sapiens_hsa005611.27492431
50Sulfur metabolism_Homo sapiens_hsa009201.24236797
51Pancreatic secretion_Homo sapiens_hsa049721.13612964
52Gap junction_Homo sapiens_hsa045401.13104512
53Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.12696132
54Vibrio cholerae infection_Homo sapiens_hsa051101.11596618
55Glucagon signaling pathway_Homo sapiens_hsa049221.11140624
56Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.10798001
57Tryptophan metabolism_Homo sapiens_hsa003801.09670553
58Drug metabolism - other enzymes_Homo sapiens_hsa009831.08563780
59Primary bile acid biosynthesis_Homo sapiens_hsa001201.06583384
60Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.02655494
61Mineral absorption_Homo sapiens_hsa049781.00339789
62Bile secretion_Homo sapiens_hsa049760.98510993
63N-Glycan biosynthesis_Homo sapiens_hsa005100.97771429
64Vascular smooth muscle contraction_Homo sapiens_hsa042700.97486334
65Tight junction_Homo sapiens_hsa045300.97056914
66Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.94153082
67cGMP-PKG signaling pathway_Homo sapiens_hsa040220.94067192
68Starch and sucrose metabolism_Homo sapiens_hsa005000.93042937
69Cocaine addiction_Homo sapiens_hsa050300.89136201
70Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.88229258
71Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.87061835
72Basal cell carcinoma_Homo sapiens_hsa052170.85885798
73GnRH signaling pathway_Homo sapiens_hsa049120.84209530
74Alzheimers disease_Homo sapiens_hsa050100.83824349
75Oxidative phosphorylation_Homo sapiens_hsa001900.83647213
76Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.82071516
77cAMP signaling pathway_Homo sapiens_hsa040240.81956781
78Chemical carcinogenesis_Homo sapiens_hsa052040.81941659
79Peroxisome_Homo sapiens_hsa041460.81309547
80Arginine biosynthesis_Homo sapiens_hsa002200.79071840
81Galactose metabolism_Homo sapiens_hsa000520.78891668
82Propanoate metabolism_Homo sapiens_hsa006400.78793486
83Fatty acid elongation_Homo sapiens_hsa000620.78011444
84Steroid hormone biosynthesis_Homo sapiens_hsa001400.76338318
85PPAR signaling pathway_Homo sapiens_hsa033200.74005246
86Estrogen signaling pathway_Homo sapiens_hsa049150.73985784
87Thyroid hormone synthesis_Homo sapiens_hsa049180.73699672
88Phenylalanine metabolism_Homo sapiens_hsa003600.73589388
89Fat digestion and absorption_Homo sapiens_hsa049750.72239409
90Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.71892565
91TGF-beta signaling pathway_Homo sapiens_hsa043500.70321077
92Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.69102559
93Malaria_Homo sapiens_hsa051440.68108716
94African trypanosomiasis_Homo sapiens_hsa051430.66643929
95Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.66485942
96Butanoate metabolism_Homo sapiens_hsa006500.65623240
97Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.64081960
98Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.64080446
99Thyroid cancer_Homo sapiens_hsa052160.62594218
100Oocyte meiosis_Homo sapiens_hsa041140.62415055
101Cardiac muscle contraction_Homo sapiens_hsa042600.58571694
102Wnt signaling pathway_Homo sapiens_hsa043100.58410047
103Hepatitis C_Homo sapiens_hsa051600.57764388
104Dilated cardiomyopathy_Homo sapiens_hsa054140.56176574
105Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.52366081
106Axon guidance_Homo sapiens_hsa043600.52168232
107Ovarian steroidogenesis_Homo sapiens_hsa049130.50483323
108Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.49913417
109Amoebiasis_Homo sapiens_hsa051460.49683108
110Alcoholism_Homo sapiens_hsa050340.49276186
111Salmonella infection_Homo sapiens_hsa051320.48838392
112beta-Alanine metabolism_Homo sapiens_hsa004100.48811629
113Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.48396018
114Arachidonic acid metabolism_Homo sapiens_hsa005900.47047898
115Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.47025824
116Circadian rhythm_Homo sapiens_hsa047100.47007020
117Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.45850948
118Notch signaling pathway_Homo sapiens_hsa043300.45827611
119Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.43266034
120Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.43172922
121Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.43112988
122Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.41587468
123Adipocytokine signaling pathway_Homo sapiens_hsa049200.41046513
124Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.39973792
125Pyruvate metabolism_Homo sapiens_hsa006200.39211737
126Phosphatidylinositol signaling system_Homo sapiens_hsa040700.38956056
127Protein digestion and absorption_Homo sapiens_hsa049740.38050045
128Maturity onset diabetes of the young_Homo sapiens_hsa049500.37830225
129Tyrosine metabolism_Homo sapiens_hsa003500.36751275
130Glycosaminoglycan degradation_Homo sapiens_hsa005310.35272980
131AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.34558827
132TNF signaling pathway_Homo sapiens_hsa046680.34442871
133Type II diabetes mellitus_Homo sapiens_hsa049300.34442202
1342-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.32881380
135Glutathione metabolism_Homo sapiens_hsa004800.31437580
136Phospholipase D signaling pathway_Homo sapiens_hsa040720.31319623
137Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.30566780
138Type I diabetes mellitus_Homo sapiens_hsa049400.30521325
139Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.30129358
140Arginine and proline metabolism_Homo sapiens_hsa003300.29903422
141Osteoclast differentiation_Homo sapiens_hsa043800.29857859
142Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.29561314
143Fatty acid biosynthesis_Homo sapiens_hsa000610.29234567
144Parkinsons disease_Homo sapiens_hsa050120.28038610
145Longevity regulating pathway - mammal_Homo sapiens_hsa042110.27362519
146VEGF signaling pathway_Homo sapiens_hsa043700.27221065
147Insulin resistance_Homo sapiens_hsa049310.27009108
148Leishmaniasis_Homo sapiens_hsa051400.26685619
149Insulin signaling pathway_Homo sapiens_hsa049100.26410202
150Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.25071628
151Ether lipid metabolism_Homo sapiens_hsa005650.24959044
152MAPK signaling pathway_Homo sapiens_hsa040100.23616966
153Glioma_Homo sapiens_hsa052140.23333806
154Transcriptional misregulation in cancer_Homo sapiens_hsa052020.22834220
155Hematopoietic cell lineage_Homo sapiens_hsa046400.22401243
156Pertussis_Homo sapiens_hsa051330.21343653
157Metabolic pathways_Homo sapiens_hsa011000.18830643
158Adherens junction_Homo sapiens_hsa045200.18478005
159Endocytosis_Homo sapiens_hsa041440.18405068
160Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.18332257
161Toxoplasmosis_Homo sapiens_hsa051450.16788877
162NOD-like receptor signaling pathway_Homo sapiens_hsa046210.16556471
163Lysosome_Homo sapiens_hsa041420.14042299
164Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.13574999
165Sulfur relay system_Homo sapiens_hsa041220.13415053
166Chemokine signaling pathway_Homo sapiens_hsa040620.11659431
167Renin-angiotensin system_Homo sapiens_hsa046140.11529117
168Fatty acid metabolism_Homo sapiens_hsa012120.11142274
169Graft-versus-host disease_Homo sapiens_hsa053320.11015893

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