INSL6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene contains a classical signature of the insulin superfamily and is significantly similar to relaxin and relaxin-like factor. This gene is preferentially expressed in testis. Its expression in testis is restricted to interstitial cells surrounding seminiferous tubules, which suggests a role in sperm development and fertilization. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G6.68816095
2neutrophil activation involved in immune response (GO:0002283)4.75998788
3cellular response to interferon-beta (GO:0035458)4.75588505
4regulation of T-helper 1 cell differentiation (GO:0045625)4.66876999
5response to interferon-beta (GO:0035456)4.43016802
6regulation of activation of Janus kinase activity (GO:0010533)4.42440325
7cellular response to type I interferon (GO:0071357)4.42255434
8type I interferon signaling pathway (GO:0060337)4.42255434
9response to type I interferon (GO:0034340)4.37305966
10negative regulation of cytosolic calcium ion concentration (GO:0051481)4.11867206
11antigen processing and presentation of endogenous antigen (GO:0019883)4.06770201
12indolalkylamine metabolic process (GO:0006586)4.03148552
13response to peptidoglycan (GO:0032494)4.02745881
14granulocyte activation (GO:0036230)3.98136627
15negative regulation of viral genome replication (GO:0045071)3.97862982
16positive regulation of interferon-alpha production (GO:0032727)3.96880049
17tryptophan catabolic process (GO:0006569)3.95496650
18indole-containing compound catabolic process (GO:0042436)3.95496650
19indolalkylamine catabolic process (GO:0046218)3.95496650
20natural killer cell mediated immunity (GO:0002228)3.91142567
21natural killer cell mediated cytotoxicity (GO:0042267)3.91142567
22immunoglobulin mediated immune response (GO:0016064)3.90192727
23regulation of RIG-I signaling pathway (GO:0039535)3.88369974
24positive regulation of natural killer cell differentiation (GO:0032825)3.84604989
25detection of light stimulus involved in sensory perception (GO:0050962)3.84224411
26detection of light stimulus involved in visual perception (GO:0050908)3.84224411
27detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.84011502
28neutrophil activation (GO:0042119)3.80903897
29piRNA metabolic process (GO:0034587)3.80782037
30antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.78331577
31antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.78331577
32defense response to protozoan (GO:0042832)3.77811589
33regulation of interferon-alpha production (GO:0032647)3.73517694
34sequestering of actin monomers (GO:0042989)3.72379754
35cellular ketone body metabolic process (GO:0046950)3.68619960
36monocyte chemotaxis (GO:0002548)3.66244812
37positive regulation of alpha-beta T cell proliferation (GO:0046641)3.65936040
38positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.64383621
39cellular response to zinc ion (GO:0071294)3.62192646
40positive regulation of gamma-delta T cell activation (GO:0046645)3.61135577
41regulation of interleukin-12 biosynthetic process (GO:0045075)3.60496395
42photoreceptor cell maintenance (GO:0045494)3.60062106
43myeloid dendritic cell differentiation (GO:0043011)3.59805382
44axoneme assembly (GO:0035082)3.59657488
45myeloid dendritic cell activation (GO:0001773)3.59050733
46tryptophan metabolic process (GO:0006568)3.58575801
47cellular response to exogenous dsRNA (GO:0071360)3.58129029
48regulation of alpha-beta T cell proliferation (GO:0046640)3.57676882
49interferon-gamma-mediated signaling pathway (GO:0060333)3.56913012
50behavioral response to ethanol (GO:0048149)3.56513597
51positive regulation of interleukin-12 production (GO:0032735)3.55228725
52L-fucose catabolic process (GO:0042355)3.54199446
53fucose catabolic process (GO:0019317)3.54199446
54L-fucose metabolic process (GO:0042354)3.54199446
55ketone body metabolic process (GO:1902224)3.53772538
56epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.52261052
57positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)3.50067619
58platelet dense granule organization (GO:0060155)3.50033253
59positive regulation of type 2 immune response (GO:0002830)3.49250522
60regulation of cilium movement (GO:0003352)3.48814885
61eosinophil chemotaxis (GO:0048245)3.46964766
62replication fork processing (GO:0031297)3.44299573
63response to pheromone (GO:0019236)3.44169151
64DNA deamination (GO:0045006)3.43840370
65behavioral response to nicotine (GO:0035095)3.42127603
66T cell migration (GO:0072678)3.41541762
67positive regulation of T-helper cell differentiation (GO:0045624)3.40045168
68positive regulation of isotype switching (GO:0045830)3.39499889
69positive regulation of monocyte chemotaxis (GO:0090026)3.39165488
70centriole replication (GO:0007099)3.39040611
71lipopolysaccharide-mediated signaling pathway (GO:0031663)3.38159257
72response to protozoan (GO:0001562)3.37287823
73positive regulation of antigen processing and presentation (GO:0002579)3.37095296
74positive regulation of lymphocyte migration (GO:2000403)3.33075756
75response to interferon-alpha (GO:0035455)3.33055706
76amine catabolic process (GO:0009310)3.30561453
77cellular biogenic amine catabolic process (GO:0042402)3.30561453
78epithelial cilium movement (GO:0003351)3.27633845
79antigen processing and presentation via MHC class Ib (GO:0002475)3.27404406
80NIK/NF-kappaB signaling (GO:0038061)3.26848828
81protein polyglutamylation (GO:0018095)3.25216047
82negative regulation of interleukin-17 production (GO:0032700)3.25197670
83regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)3.22965620
84respiratory chain complex IV assembly (GO:0008535)3.21445142
85retinal cone cell development (GO:0046549)3.20858847
86positive regulation of T cell cytokine production (GO:0002726)3.18078077
87positive regulation of inflammatory response to antigenic stimulus (GO:0002863)3.17687512
88regulation of immunoglobulin secretion (GO:0051023)3.17439135
89B cell mediated immunity (GO:0019724)3.16726250
90regulation of glucokinase activity (GO:0033131)3.16606084
91regulation of hexokinase activity (GO:1903299)3.16606084
92positive regulation of T cell migration (GO:2000406)3.15971335
93regulation of chronic inflammatory response (GO:0002676)3.15868076
94preassembly of GPI anchor in ER membrane (GO:0016254)3.13343224
95respiratory burst (GO:0045730)3.13108612
96kynurenine metabolic process (GO:0070189)3.12581696
97neural tube formation (GO:0001841)3.10816153
98positive regulation of humoral immune response (GO:0002922)3.10203286
99eosinophil migration (GO:0072677)3.09563065
100regulation of T-helper cell differentiation (GO:0045622)3.09128225
101mannosylation (GO:0097502)3.09055998
102regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)3.08852008
103positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.08727282
104hydrogen peroxide biosynthetic process (GO:0050665)3.07200815
105positive regulation of B cell mediated immunity (GO:0002714)3.06249749
106positive regulation of immunoglobulin mediated immune response (GO:0002891)3.06249749
107positive regulation of DNA recombination (GO:0045911)3.05192697
108regulation of syncytium formation by plasma membrane fusion (GO:0060142)3.03065043
109positive regulation of interleukin-2 production (GO:0032743)3.02178380
110regulation of acrosome reaction (GO:0060046)3.01882732
111T-helper 1 type immune response (GO:0042088)3.01642500
112regulation of mononuclear cell migration (GO:0071675)3.00519565
113cytochrome complex assembly (GO:0017004)3.00255604
114response to muramyl dipeptide (GO:0032495)2.99784855
115negative thymic T cell selection (GO:0045060)2.99491713
116positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)2.98907483
117negative regulation by host of viral transcription (GO:0043922)2.97215347
118DNA double-strand break processing (GO:0000729)2.97144518
119cilium morphogenesis (GO:0060271)2.96815158
120dopamine transport (GO:0015872)2.96619959
121regulation of dendritic cell antigen processing and presentation (GO:0002604)2.96465966
122positive regulation of interferon-beta production (GO:0032728)2.94293264
123regulation of chemokine biosynthetic process (GO:0045073)2.93246423
124positive regulation of chemokine biosynthetic process (GO:0045080)2.92792226
125regulation of interleukin-17 production (GO:0032660)2.92774808
126C4-dicarboxylate transport (GO:0015740)2.92652820
127fusion of sperm to egg plasma membrane (GO:0007342)2.92384823
128lymphocyte chemotaxis (GO:0048247)2.91167619
129negative T cell selection (GO:0043383)2.91070306
130positive regulation of interleukin-17 production (GO:0032740)2.89976880
131indole-containing compound metabolic process (GO:0042430)2.89322653
132dendritic cell chemotaxis (GO:0002407)2.89302891
133regulation of antigen processing and presentation (GO:0002577)2.89203106
134natural killer cell activation (GO:0030101)2.88405364
135positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)2.88328192
136cellular response to interferon-gamma (GO:0071346)2.87086472
137regulation of hypersensitivity (GO:0002883)2.86820550
138dendritic cell differentiation (GO:0097028)2.86771135
139negative regulation of cAMP-mediated signaling (GO:0043951)2.86237480
140protein complex biogenesis (GO:0070271)2.85772672
141leukocyte mediated cytotoxicity (GO:0001909)2.85610022
142cornea development in camera-type eye (GO:0061303)2.85505961
143male meiosis (GO:0007140)2.84688165
144L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.83660093
145multicellular organism reproduction (GO:0032504)2.82845433
146superoxide anion generation (GO:0042554)2.82576631
147regulation of T cell chemotaxis (GO:0010819)2.81771238
148positive regulation of T cell chemotaxis (GO:0010820)2.81771238
149regulation of interleukin-12 production (GO:0032655)2.81178280
150regulation of T-helper 2 cell differentiation (GO:0045628)2.80873890
151regulation of meiosis I (GO:0060631)2.77851030
152adaptation of signaling pathway (GO:0023058)2.77126480
153cilium organization (GO:0044782)2.76992258
154auditory receptor cell stereocilium organization (GO:0060088)2.76904086
155gamma-aminobutyric acid transport (GO:0015812)2.74957752
156cilium movement (GO:0003341)2.74162554
157regulation of rhodopsin mediated signaling pathway (GO:0022400)2.73352823
158photoreceptor cell development (GO:0042461)2.73008561
159protein K11-linked deubiquitination (GO:0035871)2.72481750
160RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.71221439
161negative regulation of mast cell activation (GO:0033004)2.70654934
162G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.69355141
163cilium assembly (GO:0042384)2.68613054
164inositol phosphate catabolic process (GO:0071545)2.67590154
165rhodopsin mediated signaling pathway (GO:0016056)2.67305206
166recombinational repair (GO:0000725)2.66977788
167double-strand break repair via homologous recombination (GO:0000724)2.66844183
168cilium or flagellum-dependent cell motility (GO:0001539)2.66318592
169establishment of protein localization to Golgi (GO:0072600)2.65697596
170prenylation (GO:0097354)2.63916156
171protein prenylation (GO:0018342)2.63916156
172branched-chain amino acid catabolic process (GO:0009083)2.63692021
173DNA methylation involved in gamete generation (GO:0043046)2.63485113
174mitochondrial respiratory chain complex I assembly (GO:0032981)2.61785138
175NADH dehydrogenase complex assembly (GO:0010257)2.61785138
176mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.61785138
177reflex (GO:0060004)2.61717461
178mitochondrial respiratory chain complex assembly (GO:0033108)2.59167064
179peptidyl-histidine modification (GO:0018202)2.57438620
180C-terminal protein lipidation (GO:0006501)2.56574456
181L-methionine salvage (GO:0071267)2.56482912
182L-methionine biosynthetic process (GO:0071265)2.56482912
183amino acid salvage (GO:0043102)2.56482912
184anterograde synaptic vesicle transport (GO:0048490)2.56425500
185polyol catabolic process (GO:0046174)2.55620230
186maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.55184184
187intraciliary transport (GO:0042073)2.54625975
188neuronal action potential (GO:0019228)2.54220549
189seminiferous tubule development (GO:0072520)2.53585893
190signal peptide processing (GO:0006465)2.52357327
191protein localization to cilium (GO:0061512)2.51645846
192sulfation (GO:0051923)2.50091411
193tachykinin receptor signaling pathway (GO:0007217)2.50029473
194RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.49789682
195tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.49789682
196DNA demethylation (GO:0080111)2.49591380
197ubiquinone biosynthetic process (GO:0006744)2.46892235
198pyrimidine nucleobase catabolic process (GO:0006208)2.46762862
199water-soluble vitamin biosynthetic process (GO:0042364)2.46709619

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human7.28104293
2IRF8_21731497_ChIP-ChIP_J774_Mouse6.21764028
3BP1_19119308_ChIP-ChIP_Hs578T_Human5.53989451
4IRF8_22096565_ChIP-ChIP_GC-B_Mouse5.41325885
5IRF1_21803131_ChIP-Seq_MONOCYTES_Human4.68041179
6FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.63745270
7IRF8_27001747_Chip-Seq_BMDM_Mouse3.63885563
8ZNF274_21170338_ChIP-Seq_K562_Hela3.61945193
9STAT4_19710469_ChIP-ChIP_TH1__Mouse3.37685627
10STAT3_20064451_ChIP-Seq_CD4+T_Mouse3.25148441
11SPI1_22096565_ChIP-ChIP_GC-B_Mouse3.19746816
12GBX2_23144817_ChIP-Seq_PC3_Human3.19137244
13VDR_22108803_ChIP-Seq_LS180_Human3.09294616
14STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.04471251
15SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.03577397
16NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.97181977
17* MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.93810604
18GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.79038064
19RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.78564089
20MYB_21317192_ChIP-Seq_ERMYB_Mouse2.66923809
21IGF1R_20145208_ChIP-Seq_DFB_Human2.62811659
22Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.59226813
23ZFP57_27257070_Chip-Seq_ESCs_Mouse2.55707818
24* POU3F2_20337985_ChIP-ChIP_501MEL_Human2.51174030
25MYB_26560356_Chip-Seq_TH2_Human2.24885747
26CTBP2_25329375_ChIP-Seq_LNCAP_Human2.20531030
27EGR1_19374776_ChIP-ChIP_THP-1_Human2.17764056
28P300_19829295_ChIP-Seq_ESCs_Human2.14615551
29SPI1_23547873_ChIP-Seq_NB4_Human2.13478957
30FUS_26573619_Chip-Seq_HEK293_Human2.12994420
31EZH2_22144423_ChIP-Seq_EOC_Human2.07048608
32FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.04952474
33CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.03090403
34RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.99246703
35CTBP1_25329375_ChIP-Seq_LNCAP_Human1.97485321
36EWS_26573619_Chip-Seq_HEK293_Human1.94464960
37TAF15_26573619_Chip-Seq_HEK293_Human1.90711555
38ER_23166858_ChIP-Seq_MCF-7_Human1.86116487
39FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.85901769
40* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.85406300
41MYB_26560356_Chip-Seq_TH1_Human1.82667068
42SALL1_21062744_ChIP-ChIP_HESCs_Human1.79042457
43CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.77810538
44FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.75638273
45RUNX_20019798_ChIP-Seq_JUKART_Human1.75330108
46SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.72593572
47STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.72012308
48CBP_20019798_ChIP-Seq_JUKART_Human1.71949246
49IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.71949246
50SCL_19346495_ChIP-Seq_HPC-7_Human1.71645254
51HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.70956334
52CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.70624763
53MAF_26560356_Chip-Seq_TH1_Human1.70266106
54HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.69492510
55BRD4_27068464_Chip-Seq_AML-cells_Mouse1.66953325
56PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.66181646
57BCAT_22108803_ChIP-Seq_LS180_Human1.66095640
58SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.64703358
59PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.64193798
60* SMAD4_21799915_ChIP-Seq_A2780_Human1.63470533
61STAT3_23295773_ChIP-Seq_U87_Human1.62482249
62RUNX1_22412390_ChIP-Seq_EML_Mouse1.59993796
63ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.59721650
64UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.58931957
65LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.57745745
66EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.57344197
67MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.56066476
68TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.55627567
69NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.54826769
70TP53_22573176_ChIP-Seq_HFKS_Human1.54603395
71PIAS1_25552417_ChIP-Seq_VCAP_Human1.53910265
72TCF4_23295773_ChIP-Seq_U87_Human1.53312192
73MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.53267946
74SUZ12_27294783_Chip-Seq_NPCs_Mouse1.52500586
75E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.51901728
76VDR_24763502_ChIP-Seq_THP-1_Human1.50577341
77TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.49896833
78POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.49896833
79IRF1_19129219_ChIP-ChIP_H3396_Human1.49819014
80PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.49778843
81PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.48929431
82VDR_24787735_ChIP-Seq_THP-1_Human1.48304090
83AR_25329375_ChIP-Seq_VCAP_Human1.48200323
84RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.47788623
85PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.47595064
86EZH2_27294783_Chip-Seq_NPCs_Mouse1.47440941
87SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.46272950
88CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.46210093
89SOX2_19829295_ChIP-Seq_ESCs_Human1.45856025
90NANOG_19829295_ChIP-Seq_ESCs_Human1.45856025
91PU_27001747_Chip-Seq_BMDM_Mouse1.44831866
92MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.43468497
93NFE2_27457419_Chip-Seq_LIVER_Mouse1.42042383
94CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.40891351
95LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.40343368
96* GATA3_27048872_Chip-Seq_THYMUS_Human1.39937185
97* GATA3_26560356_Chip-Seq_TH2_Human1.38572145
98BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.38398876
99MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.37934149
100NR3C1_21868756_ChIP-Seq_MCF10A_Human1.37803930
101PCGF2_27294783_Chip-Seq_NPCs_Mouse1.37440996
102KLF5_20875108_ChIP-Seq_MESCs_Mouse1.37418783
103SMAD3_21741376_ChIP-Seq_EPCs_Human1.34898516
104MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.34495340
105SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.34239876
106STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.33480848
107GATA2_22383799_ChIP-Seq_G1ME_Mouse1.32258705
108TCF4_22108803_ChIP-Seq_LS180_Human1.32065274
109SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.30970921
110EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.28905594
111GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.28827528
112RUNX2_22187159_ChIP-Seq_PCA_Human1.28808442
113TOP2B_26459242_ChIP-Seq_MCF-7_Human1.28608276
114FOXA1_27270436_Chip-Seq_PROSTATE_Human1.26313606
115FOXA1_25329375_ChIP-Seq_VCAP_Human1.26313606
116CRX_20693478_ChIP-Seq_RETINA_Mouse1.23929580
117GABP_17652178_ChIP-ChIP_JURKAT_Human1.23440202
118* FOXA1_21572438_ChIP-Seq_LNCaP_Human1.23206409
119FLI1_21867929_ChIP-Seq_TH2_Mouse1.19952160
120PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.19852365
121PRDM14_20953172_ChIP-Seq_ESCs_Human1.19450832
122OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.18316888
123CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.18077610
124NANOG_18555785_Chip-Seq_ESCs_Mouse1.17563211
125TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.17545833
126GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.16362475
127EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.15330994
128SMAD4_21741376_ChIP-Seq_EPCs_Human1.14774652
129AR_20517297_ChIP-Seq_VCAP_Human1.13660275
130P53_22387025_ChIP-Seq_ESCs_Mouse1.11450651
131CDX2_22108803_ChIP-Seq_LS180_Human1.08539668
132* GATA3_21878914_ChIP-Seq_MCF-7_Human1.08061645
133PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.08025485
134ELF1_17652178_ChIP-ChIP_JURKAT_Human1.07843714
135NCOR_22424771_ChIP-Seq_293T_Human1.07556789
136STAT3_18555785_Chip-Seq_ESCs_Mouse1.05566954
137ETV2_25802403_ChIP-Seq_MESCs_Mouse1.04932353
138OCT4_21477851_ChIP-Seq_ESCs_Mouse1.04630940
139MAF_26560356_Chip-Seq_TH2_Human1.04327402
140E2F1_18555785_Chip-Seq_ESCs_Mouse1.04086397
141EST1_17652178_ChIP-ChIP_JURKAT_Human1.04050405
142AR_21572438_ChIP-Seq_LNCaP_Human1.03752259
143TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.02013144
144RNF2_27304074_Chip-Seq_NSC_Mouse1.01911328
145TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.01272861
146CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01155511
147* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.00724143
148MYC_18940864_ChIP-ChIP_HL60_Human1.00637070
149PU.1_20513432_ChIP-Seq_Bcells_Mouse1.00527303
150UTX_26944678_Chip-Seq_JUKART_Human1.00130032
151SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.99922061
152AUTS2_25519132_ChIP-Seq_293T-REX_Human0.99043768
153P300_18555785_Chip-Seq_ESCs_Mouse0.99026465
154SUZ12_18555785_Chip-Seq_ESCs_Mouse0.98362591
155SPI1_23127762_ChIP-Seq_K562_Human0.97633345
156NOTCH1_21737748_ChIP-Seq_TLL_Human0.95135011
157VDR_21846776_ChIP-Seq_THP-1_Human0.93581563
158HOXB4_20404135_ChIP-ChIP_EML_Mouse0.92621773
159ERG_20887958_ChIP-Seq_HPC-7_Mouse0.87811650
160FLI1_27457419_Chip-Seq_LIVER_Mouse0.87337112
161E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.86380760
162TP63_17297297_ChIP-ChIP_HaCaT_Human0.85120359
163CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.84708477
164CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.83724217
165THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.83432922
166GATA2_21666600_ChIP-Seq_HMVEC_Human0.81358695
167SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.80892056
168* EGR1_23403033_ChIP-Seq_LIVER_Mouse0.80166154
169GATA1_22383799_ChIP-Seq_G1ME_Mouse0.79740651
170SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.79289131
171PCGF2_27294783_Chip-Seq_ESCs_Mouse0.77207685
172NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.72604502
173GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.72572675
174P300_27268052_Chip-Seq_Bcells_Human0.72148928
175KAP1_22055183_ChIP-Seq_ESCs_Mouse0.71297604
176ELK1_19687146_ChIP-ChIP_HELA_Human0.69376413
177KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.69045074
178STAT1_20625510_ChIP-Seq_HELA_Human0.66165283
179GATA3_21867929_ChIP-Seq_TH1_Mouse0.66123018
180CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.65358371
181NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.65092849
182CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.65019083
183TCF7_22412390_ChIP-Seq_EML_Mouse0.64959024
184GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.64756159
185EGR1_19032775_ChIP-ChIP_M12_Human0.64538965
186CTCF_26484167_Chip-Seq_Bcells_Mouse0.63776457
187SMRT_27268052_Chip-Seq_Bcells_Human0.63407178
188GATA1_22025678_ChIP-Seq_K562_Human0.61971596
189* ETS1_22383799_ChIP-Seq_G1ME_Mouse0.61965345
190SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.61836416
191SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.61836416
192STAT1_17558387_ChIP-Seq_HELA_Human0.60408067
193TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.60362530
194* RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.59496488

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation5.34366585
2MP0009785_altered_susceptibility_to4.24237393
3MP0002148_abnormal_hypersensitivity_rea4.01977553
4MP0005671_abnormal_response_to3.92549762
5MP0000685_abnormal_immune_system3.67468695
6MP0003436_decreased_susceptibility_to3.51332071
7MP0005000_abnormal_immune_tolerance3.35580190
8MP0006082_CNS_inflammation3.25617295
9MP0005025_abnormal_response_to3.17267727
10MP0005387_immune_system_phenotype2.97138436
11MP0001790_abnormal_immune_system2.97138436
12MP0008877_abnormal_DNA_methylation2.94413066
13MP0005551_abnormal_eye_electrophysiolog2.86504476
14MP0001800_abnormal_humoral_immune2.82506062
15MP0001968_abnormal_touch/_nociception2.79165921
16MP0002723_abnormal_immune_serum2.75966470
17MP0002419_abnormal_innate_immunity2.75339652
18MP0002452_abnormal_antigen_presenting2.75250177
19MP0005410_abnormal_fertilization2.73818846
20MP0005645_abnormal_hypothalamus_physiol2.64990536
21MP0001819_abnormal_immune_cell2.50680574
22MP0003195_calcinosis2.49517874
23MP0002420_abnormal_adaptive_immunity2.48017389
24MP0003724_increased_susceptibility_to2.46799614
25MP0002736_abnormal_nociception_after2.27311865
26MP0003880_abnormal_central_pattern2.23089106
27MP0001501_abnormal_sleep_pattern2.21359174
28MP0003763_abnormal_thymus_physiology2.20234330
29MP0002006_tumorigenesis2.17904564
30MP0002102_abnormal_ear_morphology2.16414785
31MP0005646_abnormal_pituitary_gland2.11657491
32MP0003646_muscle_fatigue2.09663040
33MP0002405_respiratory_system_inflammati2.09157766
34MP0001853_heart_inflammation2.07404951
35MP0009046_muscle_twitch2.05431909
36MP0003787_abnormal_imprinting2.02844036
37MP0002398_abnormal_bone_marrow1.97363281
38MP0002166_altered_tumor_susceptibility1.94512968
39MP0000716_abnormal_immune_system1.94382445
40MP0010155_abnormal_intestine_physiology1.92081639
41MP0004947_skin_inflammation1.91300946
42MP0005075_abnormal_melanosome_morpholog1.89731637
43MP0008872_abnormal_physiological_respon1.88871830
44MP0005253_abnormal_eye_physiology1.87767507
45MP0005464_abnormal_platelet_physiology1.87325103
46MP0001845_abnormal_inflammatory_respons1.86467383
47MP0004510_myositis1.85031073
48MP0006072_abnormal_retinal_apoptosis1.80543673
49MP0003448_altered_tumor_morphology1.80051354
50MP0004147_increased_porphyrin_level1.77690694
51MP0009764_decreased_sensitivity_to1.77191439
52MP0005310_abnormal_salivary_gland1.75975337
53MP0003718_maternal_effect1.75038132
54MP0001986_abnormal_taste_sensitivity1.74850716
55MP0002837_dystrophic_cardiac_calcinosis1.72344749
56MP0006276_abnormal_autonomic_nervous1.71598151
57MP0001545_abnormal_hematopoietic_system1.66242700
58MP0005397_hematopoietic_system_phenotyp1.66242700
59MP0009333_abnormal_splenocyte_physiolog1.62356015
60MP0003186_abnormal_redox_activity1.61221981
61MP0001984_abnormal_olfaction1.60897872
62MP0008469_abnormal_protein_level1.58485131
63MP0009745_abnormal_behavioral_response1.58402724
64MP0001486_abnormal_startle_reflex1.57605267
65MP0001533_abnormal_skeleton_physiology1.57548815
66MP0003303_peritoneal_inflammation1.57510969
67MP0002429_abnormal_blood_cell1.54043341
68MP0000858_altered_metastatic_potential1.52499395
69MP0002272_abnormal_nervous_system1.52383392
70MP0004142_abnormal_muscle_tone1.51865614
71MP0002722_abnormal_immune_system1.50207431
72MP0000689_abnormal_spleen_morphology1.49637135
73MP0009780_abnormal_chondrocyte_physiolo1.47695681
74MP0001348_abnormal_lacrimal_gland1.46144307
75MP0002735_abnormal_chemical_nociception1.43969305
76MP0001873_stomach_inflammation1.39286234
77MP0003136_yellow_coat_color1.37549377
78MP0008875_abnormal_xenobiotic_pharmacok1.35649728
79MP0001764_abnormal_homeostasis1.34638068
80MP0000427_abnormal_hair_cycle1.34327716
81MP0002163_abnormal_gland_morphology1.31547799
82MP0006292_abnormal_olfactory_placode1.29623527
83MP0002095_abnormal_skin_pigmentation1.27816064
84MP0002733_abnormal_thermal_nociception1.26467665
85MP0002638_abnormal_pupillary_reflex1.25088829
86MP0004808_abnormal_hematopoietic_stem1.24645605
87MP0002277_abnormal_respiratory_mucosa1.21596836
88MP0004782_abnormal_surfactant_physiolog1.21182992
89MP0000631_abnormal_neuroendocrine_gland1.19839568
90MP0002254_reproductive_system_inflammat1.17355181
91MP0002938_white_spotting1.15585800
92MP0004885_abnormal_endolymph1.15355545
93MP0001970_abnormal_pain_threshold1.13922587
94MP0001346_abnormal_lacrimal_gland1.13837596
95MP0002234_abnormal_pharynx_morphology1.09746089
96MP0005174_abnormal_tail_pigmentation1.08043748
97MP0010307_abnormal_tumor_latency1.07765145
98MP0002557_abnormal_social/conspecific_i1.07759891
99MP0002998_abnormal_bone_remodeling1.07501929
100MP0008995_early_reproductive_senescence1.06871330
101MP0000703_abnormal_thymus_morphology1.05241611
102MP0002572_abnormal_emotion/affect_behav1.03023380
103MP0003121_genomic_imprinting1.02574282
104MP0005084_abnormal_gallbladder_morpholo1.02296948
105MP0004924_abnormal_behavior1.02033466
106MP0005386_behavior/neurological_phenoty1.02033466
107MP0003866_abnormal_defecation0.99172077
108MP0003252_abnormal_bile_duct0.98821039
109MP0001485_abnormal_pinna_reflex0.98332714
110MP0002067_abnormal_sensory_capabilities0.98071178
111MP0009278_abnormal_bone_marrow0.97899608
112MP0005367_renal/urinary_system_phenotyp0.97332824
113MP0000516_abnormal_urinary_system0.97332824
114MP0001905_abnormal_dopamine_level0.96706585
115MP0004043_abnormal_pH_regulation0.96292863
116MP0001529_abnormal_vocalization0.96118024
117MP0000230_abnormal_systemic_arterial0.96090188
118MP0003075_altered_response_to0.95597569
119MP0009763_increased_sensitivity_to0.95130483
120MP0005389_reproductive_system_phenotype0.94696337
121MP0002653_abnormal_ependyma_morphology0.94495181
122MP0002064_seizures0.93305392
123MP0003011_delayed_dark_adaptation0.92561672
124MP0000490_abnormal_crypts_of0.92459875
125MP0002138_abnormal_hepatobiliary_system0.91760888
126MP0008775_abnormal_heart_ventricle0.89738332
127MP0005085_abnormal_gallbladder_physiolo0.89482601
128MP0002229_neurodegeneration0.89074401
129MP0002933_joint_inflammation0.88575129
130MP0005670_abnormal_white_adipose0.88506004
131MP0005195_abnormal_posterior_eye0.88444991
132MP0005058_abnormal_lysosome_morphology0.86787623
133MP0002160_abnormal_reproductive_system0.86470734
134MP0003635_abnormal_synaptic_transmissio0.85196700
135MP0001664_abnormal_digestion0.84912659
136MP0008057_abnormal_DNA_replication0.84649186
137MP0000343_altered_response_to0.84592614
138MP0004133_heterotaxia0.84202352
139MP0005171_absent_coat_pigmentation0.84029752
140MP0002928_abnormal_bile_duct0.82271424
141MP0009697_abnormal_copulation0.81814709
142MP0005166_decreased_susceptibility_to0.81801127
143MP0003453_abnormal_keratinocyte_physiol0.81789759
144MP0008789_abnormal_olfactory_epithelium0.81694652
145MP0001324_abnormal_eye_pigmentation0.81081694
146MP0005395_other_phenotype0.80399557
147MP0001963_abnormal_hearing_physiology0.79846065
148MP0010329_abnormal_lipoprotein_level0.79561482
149MP0002396_abnormal_hematopoietic_system0.79480358
150MP0004742_abnormal_vestibular_system0.79238284
151MP0000383_abnormal_hair_follicle0.79214863
152MP0006035_abnormal_mitochondrial_morpho0.79085609
153MP0005332_abnormal_amino_acid0.79016400
154MP0002751_abnormal_autonomic_nervous0.78981687
155MP0002752_abnormal_somatic_nervous0.78060230
156MP0002019_abnormal_tumor_incidence0.77799126
157MP0002909_abnormal_adrenal_gland0.77174240
158MP0003191_abnormal_cellular_cholesterol0.76385052
159MP0002136_abnormal_kidney_physiology0.70090029
160MP0010386_abnormal_urinary_bladder0.69889187
161MP0005390_skeleton_phenotype0.66596503
162MP0001851_eye_inflammation0.65870069
163MP0010352_gastrointestinal_tract_polyps0.65048379
164MP0003172_abnormal_lysosome_physiology0.64732312
165MP0002009_preneoplasia0.63386971
166MP0002877_abnormal_melanocyte_morpholog0.62625051
167MP0002132_abnormal_respiratory_system0.60490233
168MP0001663_abnormal_digestive_system0.59215310
169MP0002693_abnormal_pancreas_physiology0.57753990
170MP0005379_endocrine/exocrine_gland_phen0.57590721
171MP0003300_gastrointestinal_ulcer0.56486107
172* MP0001929_abnormal_gametogenesis0.56085763
173MP0000569_abnormal_digit_pigmentation0.55847856
174MP0009765_abnormal_xenobiotic_induced0.55816769
175MP0000371_diluted_coat_color0.55519224
176MP0003941_abnormal_skin_development0.55240424
177MP0008058_abnormal_DNA_repair0.53995595
178MP0002876_abnormal_thyroid_physiology0.53412060
179MP0000465_gastrointestinal_hemorrhage0.52548322
180MP0000015_abnormal_ear_pigmentation0.50948309
181MP0000249_abnormal_blood_vessel0.50730894
182MP0005164_abnormal_response_to0.50289891
183MP0008007_abnormal_cellular_replicative0.50251464
184* MP0003698_abnormal_male_reproductive0.49651320
185MP0000372_irregular_coat_pigmentation0.49247638
186MP0001881_abnormal_mammary_gland0.48882516

Predicted human phenotypes

RankGene SetZ-score
1Recurrent abscess formation (HP:0002722)5.69842068
2Eczematoid dermatitis (HP:0000976)5.68702560
3Elevated erythrocyte sedimentation rate (HP:0003565)5.46630945
4Recurrent bacterial skin infections (HP:0005406)5.21569240
5Increased IgM level (HP:0003496)5.17146266
6Myositis (HP:0100614)4.95303384
7Autoimmune thrombocytopenia (HP:0001973)4.64288646
8Optic neuritis (HP:0100653)4.57712006
9Retrobulbar optic neuritis (HP:0100654)4.57712006
10Pancreatic cysts (HP:0001737)4.47352970
11Orchitis (HP:0100796)4.33148567
12Nasal polyposis (HP:0100582)4.22216406
13Recurrent gram-negative bacterial infections (HP:0005420)4.20632355
14Mediastinal lymphadenopathy (HP:0100721)4.12521679
15Molar tooth sign on MRI (HP:0002419)3.89518123
16Abnormality of midbrain morphology (HP:0002418)3.89518123
17Recurrent bronchitis (HP:0002837)3.88337247
18Pancreatic fibrosis (HP:0100732)3.84794526
19Vasculitis (HP:0002633)3.79028448
20Abnormality of macrophages (HP:0004311)3.75932502
21True hermaphroditism (HP:0010459)3.75328980
22Recurrent fungal infections (HP:0002841)3.68935156
23Abnormality of T cell number (HP:0011839)3.65747679
24Congenital stationary night blindness (HP:0007642)3.63662751
25Abnormality of the nasal mucosa (HP:0000433)3.50267990
26Basal ganglia calcification (HP:0002135)3.45103171
27Absent/shortened dynein arms (HP:0200106)3.44309041
28Dynein arm defect of respiratory motile cilia (HP:0012255)3.44309041
29Recurrent skin infections (HP:0001581)3.40512196
30Nephronophthisis (HP:0000090)3.36051155
31Autoimmune hemolytic anemia (HP:0001890)3.36017825
32Stomatitis (HP:0010280)3.35107876
33Recurrent viral infections (HP:0004429)3.34380330
34Hypergammaglobulinemia (HP:0010702)3.34068778
35Attenuation of retinal blood vessels (HP:0007843)3.29810071
36Chronic otitis media (HP:0000389)3.26074016
37T lymphocytopenia (HP:0005403)3.25738081
38Intestinal atresia (HP:0011100)3.18194483
39Medial flaring of the eyebrow (HP:0010747)3.18026017
40Abnormality of the renal cortex (HP:0011035)3.17348354
41Hyperventilation (HP:0002883)3.14447541
42Gaze-evoked nystagmus (HP:0000640)3.12462882
43Abnormality of the renal medulla (HP:0100957)3.07821144
44Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.04097042
45Interstitial pulmonary disease (HP:0006530)3.02114907
46Gingivitis (HP:0000230)2.98773802
47Type II lissencephaly (HP:0007260)2.97362515
48Bronchitis (HP:0012387)2.96933736
49Chronic mucocutaneous candidiasis (HP:0002728)2.95452812
50Recurrent cutaneous fungal infections (HP:0011370)2.95452812
51Keratoconjunctivitis sicca (HP:0001097)2.93739714
52Recurrent sinusitis (HP:0011108)2.93508631
53Thrombocytosis (HP:0001894)2.92809036
54Chronic hepatic failure (HP:0100626)2.92653114
55Thyroid-stimulating hormone excess (HP:0002925)2.92002185
56Abnormality of T cells (HP:0002843)2.84809493
57Pulmonary infiltrates (HP:0002113)2.83396183
58Petechiae (HP:0000967)2.83315145
59Meningitis (HP:0001287)2.82304015
60Pustule (HP:0200039)2.81108033
61IgG deficiency (HP:0004315)2.80661574
62Cystic liver disease (HP:0006706)2.79360226
63Recurrent pneumonia (HP:0006532)2.77966963
64Obstructive lung disease (HP:0006536)2.76167722
65Chronic obstructive pulmonary disease (HP:0006510)2.76167722
66Thyroiditis (HP:0100646)2.75163758
67Vacuolated lymphocytes (HP:0001922)2.73896201
68Keratoconjunctivitis (HP:0001096)2.73364387
69Abolished electroretinogram (ERG) (HP:0000550)2.72875375
70Gastrointestinal infarctions (HP:0005244)2.72029384
71Systemic lupus erythematosus (HP:0002725)2.71556304
72Arterial thrombosis (HP:0004420)2.65192290
73Tubular atrophy (HP:0000092)2.63593303
74Leukocytosis (HP:0001974)2.61119719
75Focal motor seizures (HP:0011153)2.60832740
76Abnormal rod and cone electroretinograms (HP:0008323)2.59452477
77Inability to walk (HP:0002540)2.56251001
78Abnormal respiratory motile cilium morphology (HP:0005938)2.56249673
79Abnormal respiratory epithelium morphology (HP:0012253)2.56249673
80Combined immunodeficiency (HP:0005387)2.55350067
81Hypoplasia of the thymus (HP:0000778)2.54581163
82Severe combined immunodeficiency (HP:0004430)2.53946102
83Cellulitis (HP:0100658)2.52682129
84Eosinophilia (HP:0001880)2.52260540
85Abnormality of eosinophils (HP:0001879)2.49259662
86Pendular nystagmus (HP:0012043)2.47882505
87Bronchiectasis (HP:0002110)2.46387945
88Hemoptysis (HP:0002105)2.46216443
89Decreased central vision (HP:0007663)2.46065395
90Prostate neoplasm (HP:0100787)2.45909152
91Periodontitis (HP:0000704)2.43627496
92Renal cortical cysts (HP:0000803)2.43231407
93IgA deficiency (HP:0002720)2.42910076
94Abnormality of macular pigmentation (HP:0008002)2.42041276
95Tetraparesis (HP:0002273)2.41644777
96Aplasia/Hypoplasia of the tibia (HP:0005772)2.41457623
97Joint swelling (HP:0001386)2.41404878
98Tubulointerstitial nephritis (HP:0001970)2.40057803
99Keratoconus (HP:0000563)2.38087103
100Increased corneal curvature (HP:0100692)2.38087103
101Abnormality of T cell physiology (HP:0011840)2.37367127
102Congenital primary aphakia (HP:0007707)2.36599091
103Abnormality of cells of the lymphoid lineage (HP:0012140)2.35748367
104Gait imbalance (HP:0002141)2.35697313
105Exertional dyspnea (HP:0002875)2.35538570
106Recurrent lower respiratory tract infections (HP:0002783)2.35470612
107Chronic sinusitis (HP:0011109)2.34951310
108Abnormal respiratory motile cilium physiology (HP:0012261)2.32337731
109Poor head control (HP:0002421)2.31144968
110Fair hair (HP:0002286)2.30822301
111Aplasia/Hypoplasia of the tongue (HP:0010295)2.30222407
112Agammaglobulinemia (HP:0004432)2.29705437
113Bony spicule pigmentary retinopathy (HP:0007737)2.27566213
114Increased CSF lactate (HP:0002490)2.27023571
115Cleft eyelid (HP:0000625)2.26888777
116Volvulus (HP:0002580)2.25949712
117Lissencephaly (HP:0001339)2.25900172
118Porencephaly (HP:0002132)2.25671818
119Encephalitis (HP:0002383)2.24712949
120Abnormality of the labia minora (HP:0012880)2.24605334
121Cerebellar dysplasia (HP:0007033)2.24490299
122Sclerocornea (HP:0000647)2.24331901
123IgM deficiency (HP:0002850)2.24171332
124Rhinitis (HP:0012384)2.23548889
125Lymphopenia (HP:0001888)2.23482803
126Progressive inability to walk (HP:0002505)2.23027192
1273-Methylglutaconic aciduria (HP:0003535)2.22823640
128Urticaria (HP:0001025)2.22273648
129Absent rod-and cone-mediated responses on ERG (HP:0007688)2.21632770
130Large for gestational age (HP:0001520)2.21257755
131Granulocytopenia (HP:0001913)2.20743398
132Nephrogenic diabetes insipidus (HP:0009806)2.17560843
133Prolonged neonatal jaundice (HP:0006579)2.16537452
134Abnormal delayed hypersensitivity skin test (HP:0002963)2.15531287
135Absent speech (HP:0001344)2.15470596
136B lymphocytopenia (HP:0010976)2.15029005
137Abnormality of B cell number (HP:0010975)2.15029005
138Decreased electroretinogram (ERG) amplitude (HP:0000654)2.14397855
139Abnormality of the prostate (HP:0008775)2.14286781
140Chronic diarrhea (HP:0002028)2.14056591
141Severe visual impairment (HP:0001141)2.13532144
142Gangrene (HP:0100758)2.13113770
143Methylmalonic aciduria (HP:0012120)2.12870994
144Abnormality of the pericardium (HP:0001697)2.11523734
145Acute necrotizing encephalopathy (HP:0006965)2.11119500
146Anorexia (HP:0002039)2.10967033
147Optic nerve hypoplasia (HP:0000609)2.10641665
148Congenital hepatic fibrosis (HP:0002612)2.09007020
149Purpura (HP:0000979)2.08922786
150Thick nail (HP:0001805)2.08755589
151Polydipsia (HP:0001959)2.07063843
152Abnormal drinking behavior (HP:0030082)2.07063843
153Hypoproteinemia (HP:0003075)2.05612383
154Hypothermia (HP:0002045)2.05554205
155Acute encephalopathy (HP:0006846)2.04605980
156Gingival bleeding (HP:0000225)2.04464000
157Sepsis (HP:0100806)2.03748525
158Anencephaly (HP:0002323)2.03536918
159Mitochondrial inheritance (HP:0001427)2.03512662
160Osteomyelitis (HP:0002754)2.02657653
161Broad-based gait (HP:0002136)2.00933008
162Focal seizures (HP:0007359)1.99576942
163Postaxial foot polydactyly (HP:0001830)1.98915157
164Abnormal ciliary motility (HP:0012262)1.98893671
165Male pseudohermaphroditism (HP:0000037)1.98061565
166Progressive macrocephaly (HP:0004481)1.97502401
167Ketoacidosis (HP:0001993)1.96676553
168Methylmalonic acidemia (HP:0002912)1.93833982
169Retinal dysplasia (HP:0007973)1.93621352
170Ketosis (HP:0001946)1.93442211
171Occipital encephalocele (HP:0002085)1.92927277
172Febrile seizures (HP:0002373)1.92642655
173Genital tract atresia (HP:0001827)1.92586704
174Tubulointerstitial abnormality (HP:0001969)1.92344629
175Progressive cerebellar ataxia (HP:0002073)1.91453506
176Hemiparesis (HP:0001269)1.90835475
177Optic disc pallor (HP:0000543)1.89599008
178Retinitis pigmentosa (HP:0000510)1.89302077
179Generalized hypopigmentation of hair (HP:0011358)1.83449747
180Aplasia/Hypoplasia of the fovea (HP:0008060)1.82748222
181Hypoplasia of the fovea (HP:0007750)1.82748222
182Hepatocellular necrosis (HP:0001404)1.81830675
183Bile duct proliferation (HP:0001408)1.81470919
184Abnormal biliary tract physiology (HP:0012439)1.81470919
185Congenital sensorineural hearing impairment (HP:0008527)1.81381825
186Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.81108446
187Albinism (HP:0001022)1.81098653
188Abnormality of the ileum (HP:0001549)1.80995958
189Vaginal atresia (HP:0000148)1.80379597
190Furrowed tongue (HP:0000221)1.78250176
191Hyperglycinemia (HP:0002154)1.77746380
192Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.76930192
193Abnormal protein N-linked glycosylation (HP:0012347)1.76930192
194Abnormal protein glycosylation (HP:0012346)1.76930192
195Abnormal glycosylation (HP:0012345)1.76930192
196Short tibia (HP:0005736)1.76055706
197Abnormal mitochondria in muscle tissue (HP:0008316)1.75895746
198Aplasia/Hypoplasia of the uvula (HP:0010293)1.75579886

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK6.50017436
2MAP4K24.48826947
3MAP3K144.47389478
4PBK3.69665548
5TBK13.60328558
6TXK3.15471282
7MAP4K13.09152969
8JAK33.04704166
9PIM22.97849548
10RIPK42.87655371
11IKBKE2.85973702
12IRAK42.85779107
13TYK22.80817834
14IKBKB2.78966476
15PINK12.72676249
16BLK2.44266540
17TESK12.32365099
18NME22.27501822
19KIT2.13161924
20MAPK132.10941248
21TRIM282.08456022
22WNK32.03932175
23INSRR1.99741034
24GRK11.95329524
25JAK11.80984732
26IRAK31.79965753
27MAP3K41.79720449
28CHUK1.71977116
29ZAP701.67482021
30TEC1.63463236
31BMPR21.61309980
32BTK1.60958267
33CASK1.60951467
34MST41.59382178
35SYK1.58517992
36PIM11.48046026
37PLK21.43245953
38ADRBK11.33975878
39BCKDK1.33626768
40NEK91.32840028
41MAP3K131.32474117
42MAP2K71.23458281
43FGFR41.22809274
44STK38L1.20984514
45STK41.18262433
46PDK21.18057245
47LCK1.17236455
48CSF1R1.16911011
49IRAK11.16764721
50NLK1.14951891
51STK391.13267577
52CSNK1G31.12300388
53CSNK1G21.12110558
54PTK2B1.11546709
55OXSR11.11303408
56PRKCE1.10390205
57CSNK1G11.10149777
58BMPR1B1.09174128
59WNK41.07419992
60BCR1.07149057
61PAK31.06501451
62MARK11.05554588
63SIK31.04548360
64RPS6KA41.04034042
65PLK41.02786367
66PDK41.01875417
67PDK31.01875417
68CSNK1A1L1.00162503
69LYN0.98155234
70DAPK20.96341755
71HCK0.93470445
72EIF2AK20.93189744
73ADRBK20.92404713
74FGFR30.91203077
75ABL20.90441252
76EPHA40.89284398
77ITK0.87743964
78EIF2AK30.86863838
79PIK3CG0.86393475
80TNK20.85346054
81BMX0.84343453
82TLK10.84177203
83MKNK20.84046576
84CSK0.83252786
85FER0.80097442
86MAP2K60.80057074
87NUAK10.79750949
88PRKCG0.79385590
89DYRK20.76432729
90ERN10.75869311
91FLT30.75829730
92EPHB10.74673831
93CCNB10.74618952
94MAP3K120.74491686
95ACVR1B0.71375816
96JAK20.70995280
97ZAK0.70125304
98PKN10.69456407
99EPHA30.68960322
100MST1R0.68794078
101TGFBR10.66848810
102PRKCD0.66699196
103MAPKAPK30.66676447
104MATK0.66658377
105MKNK10.65525542
106IRAK20.65442634
107NTRK30.64935100
108MAP2K30.64688529
109ARAF0.63488931
110MAPKAPK50.62311967
111OBSCN0.60338219
112VRK20.58817382
113ABL10.57674383
114PRKCQ0.56220746
115PHKG20.56163591
116PHKG10.56163591
117GRK50.55952422
118STK100.55566800
119MAP3K50.55006777
120CAMK2A0.54887316
121YES10.54690018
122PLK30.53713942
123LRRK20.53261429
124TAOK30.52736150
125TNIK0.52719215
126BRSK20.51121025
127MAPKAPK20.50068399
128KDR0.49078057
129LATS10.49061573
130MAP3K110.47735570
131PRKCI0.46834603
132CSNK1A10.45851179
133CSNK1D0.45694080
134TRPM70.45280501
135DYRK1B0.44810463
136AKT30.43681577
137ATR0.43356403
138MARK30.43209094
139ERBB30.42870114
140PRKACA0.40907361
141PDK10.38161649
142PRKD30.37447831
143CAMK10.36863198
144FGFR20.36429080
145ATM0.36064143
146TGFBR20.33529958
147TIE10.33419583
148MUSK0.32848254
149PIK3CA0.32485243
150RPS6KA50.32465336
151FES0.31994398
152DAPK10.31993273
153PRKAA10.31661528
154IGF1R0.31162358
155DYRK1A0.30917194
156PRKCA0.30468563
157CDK80.30251975
158CLK10.30023967
159MAP3K30.29063401
160RPS6KA10.28793151
161RPS6KA60.28214978
162PLK10.27979081
163EIF2AK10.27966789
164DYRK30.27551677
165ILK0.26110730
166GRK70.25150047
167STK30.24025374
168RIPK10.22531919
169GRK60.20990771
170EGFR0.20909831
171MAP3K10.20596763
172MAP3K100.20016459
173VRK10.18827836
174PRKG20.17915152

Predicted pathways (KEGG)

RankGene SetZ-score
1Graft-versus-host disease_Homo sapiens_hsa053324.57553899
2Allograft rejection_Homo sapiens_hsa053304.22938158
3Cytosolic DNA-sensing pathway_Homo sapiens_hsa046233.47436519
4Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.97967529
5Butanoate metabolism_Homo sapiens_hsa006502.94887316
6Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.93786104
7Phototransduction_Homo sapiens_hsa047442.92103204
8Intestinal immune network for IgA production_Homo sapiens_hsa046722.91226843
9Leishmaniasis_Homo sapiens_hsa051402.84700706
10Toll-like receptor signaling pathway_Homo sapiens_hsa046202.58362099
11NF-kappa B signaling pathway_Homo sapiens_hsa040642.57537894
12Type I diabetes mellitus_Homo sapiens_hsa049402.52610764
13NOD-like receptor signaling pathway_Homo sapiens_hsa046212.44409167
14Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.40546992
15Measles_Homo sapiens_hsa051622.36983544
16Autoimmune thyroid disease_Homo sapiens_hsa053202.31367033
17RIG-I-like receptor signaling pathway_Homo sapiens_hsa046222.31237025
18Nitrogen metabolism_Homo sapiens_hsa009102.30344931
19alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.29627555
20Linoleic acid metabolism_Homo sapiens_hsa005912.26807173
21Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.23478195
22Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.23044901
23Legionellosis_Homo sapiens_hsa051342.21608584
24Primary immunodeficiency_Homo sapiens_hsa053402.20547267
25Rheumatoid arthritis_Homo sapiens_hsa053232.14208651
26Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.11170598
27Propanoate metabolism_Homo sapiens_hsa006402.03251123
28Fanconi anemia pathway_Homo sapiens_hsa034602.00732830
29Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.00725453
30Antigen processing and presentation_Homo sapiens_hsa046121.97580164
31Tryptophan metabolism_Homo sapiens_hsa003801.96252588
32Asthma_Homo sapiens_hsa053101.91092924
33Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.87202408
34Influenza A_Homo sapiens_hsa051641.82777431
35Malaria_Homo sapiens_hsa051441.82492196
36Osteoclast differentiation_Homo sapiens_hsa043801.81950311
37Olfactory transduction_Homo sapiens_hsa047401.80475618
38TNF signaling pathway_Homo sapiens_hsa046681.78152892
39Herpes simplex infection_Homo sapiens_hsa051681.76435198
40Pertussis_Homo sapiens_hsa051331.72831045
41Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.67949724
42Ether lipid metabolism_Homo sapiens_hsa005651.67942810
43Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.62792490
44Maturity onset diabetes of the young_Homo sapiens_hsa049501.61668159
45Tuberculosis_Homo sapiens_hsa051521.55824061
46Jak-STAT signaling pathway_Homo sapiens_hsa046301.55396748
47Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.54630865
48African trypanosomiasis_Homo sapiens_hsa051431.54161843
49Nicotine addiction_Homo sapiens_hsa050331.53527752
50Primary bile acid biosynthesis_Homo sapiens_hsa001201.53462340
51Peroxisome_Homo sapiens_hsa041461.53339394
52Steroid hormone biosynthesis_Homo sapiens_hsa001401.52823561
53Toxoplasmosis_Homo sapiens_hsa051451.52325775
54Salmonella infection_Homo sapiens_hsa051321.43454962
55Hematopoietic cell lineage_Homo sapiens_hsa046401.42325677
56ABC transporters_Homo sapiens_hsa020101.41346947
57Taste transduction_Homo sapiens_hsa047421.37550799
58Oxidative phosphorylation_Homo sapiens_hsa001901.36373904
59B cell receptor signaling pathway_Homo sapiens_hsa046621.35705120
60Viral myocarditis_Homo sapiens_hsa054161.34540773
61Staphylococcus aureus infection_Homo sapiens_hsa051501.28970960
62Non-homologous end-joining_Homo sapiens_hsa034501.28415535
63Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.23917454
64Proteasome_Homo sapiens_hsa030501.23501577
65Apoptosis_Homo sapiens_hsa042101.22646156
66Chemokine signaling pathway_Homo sapiens_hsa040621.17997391
67beta-Alanine metabolism_Homo sapiens_hsa004101.12009180
68T cell receptor signaling pathway_Homo sapiens_hsa046601.10968236
69Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.08540592
70Shigellosis_Homo sapiens_hsa051311.05414093
71Morphine addiction_Homo sapiens_hsa050321.04202105
72Selenocompound metabolism_Homo sapiens_hsa004501.00035739
73Parkinsons disease_Homo sapiens_hsa050120.98301928
74Purine metabolism_Homo sapiens_hsa002300.95968901
75Fatty acid degradation_Homo sapiens_hsa000710.95035798
76Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.94566840
77Retinol metabolism_Homo sapiens_hsa008300.94483601
78Glycerolipid metabolism_Homo sapiens_hsa005610.93448113
79Hepatitis B_Homo sapiens_hsa051610.92614957
80Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.91056035
81Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.90691388
82Pentose and glucuronate interconversions_Homo sapiens_hsa000400.90659147
83Salivary secretion_Homo sapiens_hsa049700.90336008
84Cyanoamino acid metabolism_Homo sapiens_hsa004600.90160257
85Ovarian steroidogenesis_Homo sapiens_hsa049130.87029355
86One carbon pool by folate_Homo sapiens_hsa006700.86965188
87Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.86197592
88Circadian entrainment_Homo sapiens_hsa047130.85975701
89Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.85496699
90Phagosome_Homo sapiens_hsa041450.85274682
91Dorso-ventral axis formation_Homo sapiens_hsa043200.83163933
92Regulation of autophagy_Homo sapiens_hsa041400.83002987
93Hepatitis C_Homo sapiens_hsa051600.79618966
94Fatty acid metabolism_Homo sapiens_hsa012120.78432830
95Serotonergic synapse_Homo sapiens_hsa047260.76700435
96Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.76374240
97Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.75209326
98Cysteine and methionine metabolism_Homo sapiens_hsa002700.73591487
99Metabolic pathways_Homo sapiens_hsa011000.72885303
100Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.71261377
101Calcium signaling pathway_Homo sapiens_hsa040200.70185427
102Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.69932462
103AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.69834660
104Glutamatergic synapse_Homo sapiens_hsa047240.69807868
105Other glycan degradation_Homo sapiens_hsa005110.69780581
106Ribosome_Homo sapiens_hsa030100.68421912
107Epstein-Barr virus infection_Homo sapiens_hsa051690.68035266
108Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.67475963
109Lysosome_Homo sapiens_hsa041420.66125806
110Acute myeloid leukemia_Homo sapiens_hsa052210.64654246
111Fatty acid elongation_Homo sapiens_hsa000620.64621487
112Sphingolipid metabolism_Homo sapiens_hsa006000.63701363
113GABAergic synapse_Homo sapiens_hsa047270.63289786
114Insulin secretion_Homo sapiens_hsa049110.62763588
115Circadian rhythm_Homo sapiens_hsa047100.60484915
116Leukocyte transendothelial migration_Homo sapiens_hsa046700.60373139
117Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.59196771
118Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.59192039
119Transcriptional misregulation in cancer_Homo sapiens_hsa052020.57183384
120Huntingtons disease_Homo sapiens_hsa050160.56771085
121Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.53496519
122Glycerophospholipid metabolism_Homo sapiens_hsa005640.53298516
123Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.51884027
124Prolactin signaling pathway_Homo sapiens_hsa049170.51589228
125Alzheimers disease_Homo sapiens_hsa050100.51368611
126SNARE interactions in vesicular transport_Homo sapiens_hsa041300.48782054
127Histidine metabolism_Homo sapiens_hsa003400.48289242
128Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.47017169
129Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.45836732
130Fat digestion and absorption_Homo sapiens_hsa049750.45818080
131Long-term depression_Homo sapiens_hsa047300.43365560
132p53 signaling pathway_Homo sapiens_hsa041150.42698415
133Glutathione metabolism_Homo sapiens_hsa004800.39696014
134Caffeine metabolism_Homo sapiens_hsa002320.39422517
135Chemical carcinogenesis_Homo sapiens_hsa052040.39037497
136Systemic lupus erythematosus_Homo sapiens_hsa053220.37504455
137Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.36320503
138Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.36049662
139HTLV-I infection_Homo sapiens_hsa051660.35909058
140Collecting duct acid secretion_Homo sapiens_hsa049660.35861833
141Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.35306947
142Steroid biosynthesis_Homo sapiens_hsa001000.35305398
143Vascular smooth muscle contraction_Homo sapiens_hsa042700.35191486
144Amoebiasis_Homo sapiens_hsa051460.33411241
145Viral carcinogenesis_Homo sapiens_hsa052030.33033440
146Adipocytokine signaling pathway_Homo sapiens_hsa049200.32943072
147Renin secretion_Homo sapiens_hsa049240.32168888
148Sulfur metabolism_Homo sapiens_hsa009200.31960989
149Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.30794951
150Platelet activation_Homo sapiens_hsa046110.30263284
151Pyrimidine metabolism_Homo sapiens_hsa002400.29163660
152Pentose phosphate pathway_Homo sapiens_hsa000300.28519799
153Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.27086933
154Carbohydrate digestion and absorption_Homo sapiens_hsa049730.25860964
155Chronic myeloid leukemia_Homo sapiens_hsa052200.25821839
156Small cell lung cancer_Homo sapiens_hsa052220.24985323
157Prion diseases_Homo sapiens_hsa050200.23252213
158Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.23040198
159Pancreatic cancer_Homo sapiens_hsa052120.22783188
160DNA replication_Homo sapiens_hsa030300.22606116
161Mineral absorption_Homo sapiens_hsa049780.20714545
162Glycosaminoglycan degradation_Homo sapiens_hsa005310.19209587
163Base excision repair_Homo sapiens_hsa034100.18675599
164Galactose metabolism_Homo sapiens_hsa000520.17491457
165Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.16652160
166Homologous recombination_Homo sapiens_hsa034400.15803822
167Arachidonic acid metabolism_Homo sapiens_hsa005900.15139083
168HIF-1 signaling pathway_Homo sapiens_hsa040660.15039519
169Basal transcription factors_Homo sapiens_hsa030220.14547905
170RNA degradation_Homo sapiens_hsa030180.13565224
171Protein export_Homo sapiens_hsa030600.12949685
172RNA polymerase_Homo sapiens_hsa030200.12138551
173Neurotrophin signaling pathway_Homo sapiens_hsa047220.11757107

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