INSM1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Insulinoma-associated 1 (INSM1) gene is intronless and encodes a protein containing both a zinc finger DNA-binding domain and a putative prohormone domain. This gene is a sensitive marker for neuroendocrine differentiation of human lung tumors. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1COPI coating of Golgi vesicle (GO:0048205)8.02970163
2Golgi transport vesicle coating (GO:0048200)8.02970163
3* endocrine pancreas development (GO:0031018)6.11785808
4behavioral response to nicotine (GO:0035095)5.83707129
5pyrimidine nucleobase catabolic process (GO:0006208)5.75083936
6protein maturation by protein folding (GO:0022417)5.19901718
7regulation of type B pancreatic cell apoptotic process (GO:2000674)5.06944853
8peptide hormone processing (GO:0016486)4.99098827
9* glandular epithelial cell differentiation (GO:0002067)4.93538328
10insulin secretion (GO:0030073)4.91454327
11maintenance of protein localization in endoplasmic reticulum (GO:0035437)4.81040398
12axonal fasciculation (GO:0007413)4.77525937
13nucleobase catabolic process (GO:0046113)4.73814105
14retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)4.70642185
15COPII vesicle coating (GO:0048208)4.66934574
16astrocyte differentiation (GO:0048708)4.63735528
17regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022354.60030952
18neuron recognition (GO:0008038)4.54877655
19substrate-independent telencephalic tangential interneuron migration (GO:0021843)4.53440522
20substrate-independent telencephalic tangential migration (GO:0021826)4.53440522
21exocrine pancreas development (GO:0031017)4.50958494
22activation of signaling protein activity involved in unfolded protein response (GO:0006987)4.44739631
23* type B pancreatic cell development (GO:0003323)4.40245166
24response to dietary excess (GO:0002021)4.30621219
25positive regulation of nuclease activity (GO:0032075)4.25909314
26* glandular epithelial cell development (GO:0002068)4.24573700
27ER overload response (GO:0006983)4.23439734
28epithelial cell fate commitment (GO:0072148)4.21670331
29cell migration in hindbrain (GO:0021535)4.21584197
30nitric oxide mediated signal transduction (GO:0007263)4.20884744
31positive regulation of growth hormone secretion (GO:0060124)4.18289746
32positive regulation of gastrulation (GO:2000543)4.16256634
33regulation of inhibitory postsynaptic membrane potential (GO:0060080)4.13305819
34postsynaptic membrane organization (GO:0001941)4.05786780
35positive regulation of synaptic transmission, dopaminergic (GO:0032226)4.03581881
36protein retention in ER lumen (GO:0006621)4.02728230
37positive regulation of insulin secretion (GO:0032024)4.00589020
38dendritic spine morphogenesis (GO:0060997)3.98209638
39forebrain neuron differentiation (GO:0021879)3.97086900
40embryonic retina morphogenesis in camera-type eye (GO:0060059)3.92917003
41regulation of nuclease activity (GO:0032069)3.89296654
42auditory behavior (GO:0031223)3.88354077
43cerebellar Purkinje cell layer development (GO:0021680)3.87924472
44spinal cord association neuron differentiation (GO:0021527)3.86771851
45neuron fate determination (GO:0048664)3.86339376
46negative regulation of norepinephrine secretion (GO:0010700)3.84464684
47regulation of insulin secretion (GO:0050796)3.83802692
48vesicle coating (GO:0006901)3.78070975
49presynaptic membrane organization (GO:0097090)3.75477662
50regulation of growth hormone secretion (GO:0060123)3.73821391
51chemosensory behavior (GO:0007635)3.70252565
52regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.70237806
53membrane repolarization during cardiac muscle cell action potential (GO:0086013)3.67150562
54endoplasmic reticulum unfolded protein response (GO:0030968)3.62485158
55negative regulation of cytosolic calcium ion concentration (GO:0051481)3.62419733
56cellular response to vitamin D (GO:0071305)3.60713510
57positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.56758162
58cellular response to unfolded protein (GO:0034620)3.54462596
59spinal cord development (GO:0021510)3.51052588
60* columnar/cuboidal epithelial cell development (GO:0002066)3.50989224
61mechanosensory behavior (GO:0007638)3.50735313
62peptide hormone secretion (GO:0030072)3.49694417
63ER-nucleus signaling pathway (GO:0006984)3.49157341
64regulation of peptide hormone secretion (GO:0090276)3.47882028
65cerebellar Purkinje cell differentiation (GO:0021702)3.47086572
66retinal ganglion cell axon guidance (GO:0031290)3.45374724
67regulation of synapse structural plasticity (GO:0051823)3.43008999
68regulation of peptide secretion (GO:0002791)3.42733288
69positive regulation of hormone biosynthetic process (GO:0046886)3.42526190
70cell differentiation in hindbrain (GO:0021533)3.42345538
71peptide secretion (GO:0002790)3.41635443
72synapse assembly (GO:0007416)3.39921588
73cellular response to topologically incorrect protein (GO:0035967)3.39095473
74detection of calcium ion (GO:0005513)3.38369588
75presynaptic membrane assembly (GO:0097105)3.38050077
76membrane repolarization during action potential (GO:0086011)3.34736730
77adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)3.34043162
78dentate gyrus development (GO:0021542)3.33865711
79transmission of nerve impulse (GO:0019226)3.31552388
80negative regulation of catecholamine secretion (GO:0033604)3.30190133
81neuron cell-cell adhesion (GO:0007158)3.27844978
82L-alpha-amino acid transmembrane transport (GO:1902475)3.27133960
83macroautophagy (GO:0016236)3.23470990
84olfactory bulb development (GO:0021772)3.23086211
85synaptic vesicle maturation (GO:0016188)3.20966657
86neuron fate specification (GO:0048665)3.18989354
87positive regulation of peptide hormone secretion (GO:0090277)3.15057576
88ER-associated ubiquitin-dependent protein catabolic process (GO:0030433)3.15035100
89regulation of short-term neuronal synaptic plasticity (GO:0048172)3.14273291
90negative regulation of glycogen biosynthetic process (GO:0045719)3.13704596
91cell differentiation in spinal cord (GO:0021515)3.13208477
92nonmotile primary cilium assembly (GO:0035058)3.12881895
93establishment of mitochondrion localization (GO:0051654)3.11856093
94positive regulation of oligodendrocyte differentiation (GO:0048714)3.10347370
95glycerophospholipid catabolic process (GO:0046475)3.08950386
96synaptic transmission, cholinergic (GO:0007271)3.08648320
97body morphogenesis (GO:0010171)3.08207472
98calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)3.06267298
99intra-Golgi vesicle-mediated transport (GO:0006891)3.06107946
100neuron maturation (GO:0042551)3.04599930
101cellular response to glucagon stimulus (GO:0071377)3.03917144
102cell proliferation in forebrain (GO:0021846)3.03906908
103photoreceptor cell differentiation (GO:0046530)3.03104744
104eye photoreceptor cell differentiation (GO:0001754)3.03104744
105positive regulation of peptide secretion (GO:0002793)3.03077389
106central nervous system projection neuron axonogenesis (GO:0021952)3.02280613
107regulation of hormone secretion (GO:0046883)3.02119987
108cerebral cortex radially oriented cell migration (GO:0021799)3.00299763
109locomotory exploration behavior (GO:0035641)2.99560459
110inner ear receptor cell development (GO:0060119)2.97914576
111synaptic transmission, glutamatergic (GO:0035249)2.96787109
112negative regulation of insulin secretion (GO:0046676)2.96461320
113negative regulation of calcium ion-dependent exocytosis (GO:0045955)2.96155217
114establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.95913934
115mitochondrion transport along microtubule (GO:0047497)2.95913934
116negative regulation of gluconeogenesis (GO:0045721)2.95803826
117axon extension (GO:0048675)2.95704527
118regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.95608715
119response to auditory stimulus (GO:0010996)2.93375867
120sequestering of metal ion (GO:0051238)2.93360715
121regulation of transcription involved in cell fate commitment (GO:0060850)2.92921366
122protein targeting to Golgi (GO:0000042)2.92562809
123response to endoplasmic reticulum stress (GO:0034976)2.91672689
124pancreas development (GO:0031016)2.90874828
125epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.89889404
126dendrite morphogenesis (GO:0048813)2.89309774
127regulation of Golgi to plasma membrane protein transport (GO:0042996)2.89216577
128regulation of neuron migration (GO:2001222)2.88865002
129cornea development in camera-type eye (GO:0061303)2.88584735
130protein localization to synapse (GO:0035418)2.88426751
131intestinal epithelial cell development (GO:0060576)2.87094958
132regulation of beta-amyloid formation (GO:1902003)2.85932486
133cerebellar granule cell differentiation (GO:0021707)2.85722676
134neurofilament cytoskeleton organization (GO:0060052)2.84640159
135regulation of calcium ion-dependent exocytosis (GO:0017158)2.84371508
136regulation of peptide transport (GO:0090087)2.81810519
137regulation of glucocorticoid secretion (GO:2000849)2.80545487
138negative regulation of bone resorption (GO:0045779)2.78536594
139response to hepatocyte growth factor (GO:0035728)2.78141085
140cellular response to hepatocyte growth factor stimulus (GO:0035729)2.78141085
141hindbrain development (GO:0030902)2.77983603
142ionotropic glutamate receptor signaling pathway (GO:0035235)2.77748974
143negative regulation of glycoprotein biosynthetic process (GO:0010561)2.77346386
144exploration behavior (GO:0035640)2.76801583
145genetic imprinting (GO:0071514)2.76058437
146neuronal ion channel clustering (GO:0045161)2.75215280
147hormone secretion (GO:0046879)2.75013899
148protein localization to Golgi apparatus (GO:0034067)2.74371588
149dopaminergic neuron differentiation (GO:0071542)2.73324207
150Golgi organization (GO:0007030)2.72140882
151adult walking behavior (GO:0007628)2.71873680
152cerebellum development (GO:0021549)2.71185656
153neuromuscular synaptic transmission (GO:0007274)2.71124157
154epithelial cell maturation (GO:0002070)2.70797811
155suckling behavior (GO:0001967)2.70239596
156neuron migration (GO:0001764)2.69867045
157membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.68578314
158dorsal/ventral axis specification (GO:0009950)2.67738702
159ER to Golgi vesicle-mediated transport (GO:0006888)2.67718169
160regulation of respiratory system process (GO:0044065)2.66575124
161neurotransmitter-gated ion channel clustering (GO:0072578)2.64625656
162peptide transport (GO:0015833)2.64089779
163central nervous system neuron differentiation (GO:0021953)2.63181586
164negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.62530674
165epithelial cilium movement (GO:0003351)2.62374075
166dendrite development (GO:0016358)2.61796464
167peptidyl-asparagine modification (GO:0018196)2.60999851
168regulation of glutamate receptor signaling pathway (GO:1900449)2.60521019
169positive regulation of hormone secretion (GO:0046887)2.60126030
170protein N-linked glycosylation via asparagine (GO:0018279)2.60039355
171stress granule assembly (GO:0034063)2.59884446
172histone H3-K9 demethylation (GO:0033169)2.59809429
173smoothened signaling pathway (GO:0007224)2.59771132
174negative regulation of glycogen metabolic process (GO:0070874)2.58976981
175retrograde transport, vesicle recycling within Golgi (GO:0000301)2.58794607
176ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:0043162.58402794
177response to unfolded protein (GO:0006986)2.57988970
178interleukin-1-mediated signaling pathway (GO:0070498)2.57359045
179hippocampus development (GO:0021766)2.56129764
180hormone transport (GO:0009914)2.55446164
181regulation of norepinephrine secretion (GO:0014061)2.55223942
182camera-type eye morphogenesis (GO:0048593)2.55077685
183positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.53781272
184head development (GO:0060322)2.52853594
185neuron-neuron synaptic transmission (GO:0007270)2.52317148
186somite rostral/caudal axis specification (GO:0032525)2.51905829
187limb development (GO:0060173)2.51538912
188appendage development (GO:0048736)2.51538912
189positive regulation of synapse assembly (GO:0051965)2.51045712

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse5.88468837
2EZH2_22144423_ChIP-Seq_EOC_Human3.67849981
3RBPJ_22232070_ChIP-Seq_NCS_Mouse2.93635048
4DMRT1_21621532_ChIP-ChIP_FETAL_Ovary2.70766858
5IGF1R_20145208_ChIP-Seq_DFB_Human2.67164812
6* REST_21632747_ChIP-Seq_MESCs_Mouse2.45248490
7STAT6_21828071_ChIP-Seq_BEAS2B_Human2.43730393
8* EZH2_27304074_Chip-Seq_ESCs_Mouse2.18969550
9* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.99280772
10* OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.97342634
11RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.96897256
12GATA1_22025678_ChIP-Seq_K562_Human1.94761390
13TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.91004948
14REST_18959480_ChIP-ChIP_MESCs_Mouse1.90327850
15* RNF2_27304074_Chip-Seq_ESCs_Mouse1.89910572
16* EZH2_27294783_Chip-Seq_ESCs_Mouse1.86225912
17PKCTHETA_26484144_Chip-Seq_BREAST_Human1.85857301
18* SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.85672256
19* JARID2_20075857_ChIP-Seq_MESCs_Mouse1.84179512
20ERG_21242973_ChIP-ChIP_JURKAT_Human1.80390284
21* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.80311572
22HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.77508382
23* TP53_20018659_ChIP-ChIP_R1E_Mouse1.77030867
24* JARID2_20064375_ChIP-Seq_MESCs_Mouse1.75400814
25NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.74345109
26SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.71829012
27* SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.69867622
28* TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.69280467
29* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.68321860
30GBX2_23144817_ChIP-Seq_PC3_Human1.66180679
31* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.65499587
32CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.60666095
33* RNF2_18974828_ChIP-Seq_MESCs_Mouse1.60329069
34* EZH2_18974828_ChIP-Seq_MESCs_Mouse1.60329069
35PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.59853303
36GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.59588970
37NR3C1_23031785_ChIP-Seq_PC12_Mouse1.59100923
38DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.58484679
39* EED_16625203_ChIP-ChIP_MESCs_Mouse1.58213515
40ZNF274_21170338_ChIP-Seq_K562_Hela1.57032634
41ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.56186064
42BMI1_23680149_ChIP-Seq_NPCS_Mouse1.55131566
43* TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.53654345
44* POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.53654345
45PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.50772940
46RARB_27405468_Chip-Seq_BRAIN_Mouse1.50627432
47NFIB_24661679_ChIP-Seq_LUNG_Mouse1.49883282
48ZFP57_27257070_Chip-Seq_ESCs_Mouse1.48014277
49CTBP1_25329375_ChIP-Seq_LNCAP_Human1.45619122
50ZNF217_24962896_ChIP-Seq_MCF-7_Human1.45370118
51KDM2B_26808549_Chip-Seq_K562_Human1.44408807
52EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.42117977
53STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.41964619
54ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.41839488
55STAT3_23295773_ChIP-Seq_U87_Human1.41024954
56* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.40634957
57FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.37721350
58TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.37242962
59YAP1_20516196_ChIP-Seq_MESCs_Mouse1.36714948
60* RING1B_27294783_Chip-Seq_NPCs_Mouse1.36081727
61* SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.35140619
62IKZF1_21737484_ChIP-ChIP_HCT116_Human1.31850872
63BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.31743198
64POU3F2_20337985_ChIP-ChIP_501MEL_Human1.31313565
65GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.31230338
66DROSHA_22980978_ChIP-Seq_HELA_Human1.29874910
67CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.28725671
68AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.26140032
69ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.25743673
70* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.20713342
71REST_19997604_ChIP-ChIP_NEURONS_Mouse1.18126923
72PIAS1_25552417_ChIP-Seq_VCAP_Human1.18057372
73SMAD3_21741376_ChIP-Seq_ESCs_Human1.17492356
74WT1_25993318_ChIP-Seq_PODOCYTE_Human1.16696152
75SMAD4_21799915_ChIP-Seq_A2780_Human1.15913068
76CTCF_27219007_Chip-Seq_Bcells_Human1.15856615
77OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.15797787
78TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.15090813
79SOX2_21211035_ChIP-Seq_LN229_Gbm1.14956960
80* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.13275754
81SOX2_27498859_Chip-Seq_STOMACH_Mouse1.11872463
82* STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.11426071
83AR_19668381_ChIP-Seq_PC3_Human1.10880521
84SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.09703896
85* LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08548824
86* PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.08201914
87ISL1_27105846_Chip-Seq_CPCs_Mouse1.08183164
88CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.06908118
89FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.06719835
90CTBP2_25329375_ChIP-Seq_LNCAP_Human1.06484267
91* TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.05298441
92SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.05253789
93PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.05247833
94TCF4_23295773_ChIP-Seq_U87_Human1.05184601
95* RNF2_27304074_Chip-Seq_NSC_Mouse1.02738747
96* RING1B_27294783_Chip-Seq_ESCs_Mouse1.02556010
97KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.02320644
98AHR_22903824_ChIP-Seq_MCF-7_Human1.02199430
99* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.02012703
100VDR_22108803_ChIP-Seq_LS180_Human1.01720326
101BCAT_22108803_ChIP-Seq_LS180_Human1.00933937
102* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.00697447
103HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.00031515
104TAF15_26573619_Chip-Seq_HEK293_Human0.98792220
105BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.97971778
106* SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.97724454
107RUNX1_26923725_Chip-Seq_HPCs_Mouse0.97370126
108* CBX2_27304074_Chip-Seq_ESCs_Mouse0.97211052
109* POU5F1_16153702_ChIP-ChIP_HESCs_Human0.97092426
110SMAD3_21741376_ChIP-Seq_EPCs_Human0.96195883
111SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.96127723
112FOXA1_25552417_ChIP-Seq_VCAP_Human0.95433020
113CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.95214952
114TDRD3_21172665_ChIP-Seq_MCF-7_Human0.94861121
115SMAD4_21741376_ChIP-Seq_HESCs_Human0.93863237
116ARNT_22903824_ChIP-Seq_MCF-7_Human0.93439965
117RUNX2_22187159_ChIP-Seq_PCA_Human0.91581786
118* AR_25329375_ChIP-Seq_VCAP_Human0.91498664
119P53_22127205_ChIP-Seq_FIBROBLAST_Human0.91230416
120FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.91201497
121GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.90501261
122* FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.89698855
123CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.89271890
124TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.89259239
125* GF1B_26923725_Chip-Seq_HPCs_Mouse0.89124245
126P300_19829295_ChIP-Seq_ESCs_Human0.87624121
127ZFP281_27345836_Chip-Seq_ESCs_Mouse0.87461238
128MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.87398228
129CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.87025599
130* TP63_19390658_ChIP-ChIP_HaCaT_Human0.86548841
131IRF1_19129219_ChIP-ChIP_H3396_Human0.86343609
132SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.84544051
133SETDB1_19884257_ChIP-Seq_MESCs_Mouse0.82254702
134* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.80563990
135* ZFP281_18757296_ChIP-ChIP_E14_Mouse0.79641153

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002877_abnormal_melanocyte_morpholog4.78753966
2MP0003283_abnormal_digestive_organ4.13929391
3MP0002909_abnormal_adrenal_gland3.81549608
4MP0002693_abnormal_pancreas_physiology3.78316341
5MP0003123_paternal_imprinting3.62607671
6MP0009780_abnormal_chondrocyte_physiolo3.53708575
7* MP0001944_abnormal_pancreas_morphology3.29385661
8MP0000678_abnormal_parathyroid_gland3.22700564
9MP0005379_endocrine/exocrine_gland_phen3.03352635
10MP0006072_abnormal_retinal_apoptosis2.87852758
11MP0003183_abnormal_peptide_metabolism2.86007814
12MP0002822_catalepsy2.84409094
13MP0004043_abnormal_pH_regulation2.59077047
14MP0010386_abnormal_urinary_bladder2.48656747
15MP0002638_abnormal_pupillary_reflex2.43721243
16MP0000013_abnormal_adipose_tissue2.42975345
17MP0003880_abnormal_central_pattern2.41509929
18MP0005645_abnormal_hypothalamus_physiol2.36477875
19MP0002234_abnormal_pharynx_morphology2.35034718
20MP0006292_abnormal_olfactory_placode2.26679758
21MP0005187_abnormal_penis_morphology2.25752184
22MP0005423_abnormal_somatic_nervous2.24625436
23MP0001188_hyperpigmentation2.24230045
24MP0005220_abnormal_exocrine_pancreas2.17290912
25MP0003195_calcinosis2.11490670
26MP0001346_abnormal_lacrimal_gland2.09433842
27MP0003787_abnormal_imprinting2.04754432
28MP0004859_abnormal_synaptic_plasticity2.02595126
29MP0000631_abnormal_neuroendocrine_gland1.92206455
30MP0001986_abnormal_taste_sensitivity1.87266002
31MP0008789_abnormal_olfactory_epithelium1.85310216
32MP0002272_abnormal_nervous_system1.76850605
33MP0002078_abnormal_glucose_homeostasis1.76242811
34MP0002163_abnormal_gland_morphology1.71486968
35MP0005646_abnormal_pituitary_gland1.67580856
36MP0008961_abnormal_basal_metabolism1.65610642
37MP0002063_abnormal_learning/memory/cond1.64920856
38MP0009745_abnormal_behavioral_response1.64659686
39MP0002572_abnormal_emotion/affect_behav1.63439599
40MP0002876_abnormal_thyroid_physiology1.62258967
41MP0000613_abnormal_salivary_gland1.60400282
42MP0004133_heterotaxia1.58786265
43MP0004270_analgesia1.57296204
44MP0000003_abnormal_adipose_tissue1.55624418
45MP0005253_abnormal_eye_physiology1.55389731
46MP0001529_abnormal_vocalization1.52010411
47MP0009379_abnormal_foot_pigmentation1.51799284
48MP0001440_abnormal_grooming_behavior1.49359963
49MP0008004_abnormal_stomach_pH1.47947350
50MP0003890_abnormal_embryonic-extraembry1.47272782
51MP0002896_abnormal_bone_mineralization1.46063149
52MP0009046_muscle_twitch1.44375679
53MP0004145_abnormal_muscle_electrophysio1.43600162
54MP0002653_abnormal_ependyma_morphology1.42940659
55MP0004142_abnormal_muscle_tone1.42568896
56MP0008877_abnormal_DNA_methylation1.42408701
57MP0005499_abnormal_olfactory_system1.41771348
58MP0005394_taste/olfaction_phenotype1.41771348
59MP0004742_abnormal_vestibular_system1.40981865
60MP0001348_abnormal_lacrimal_gland1.38031852
61MP0003300_gastrointestinal_ulcer1.36887146
62MP0001970_abnormal_pain_threshold1.35944984
63MP0001502_abnormal_circadian_rhythm1.34766923
64MP0002067_abnormal_sensory_capabilities1.33167896
65MP0005310_abnormal_salivary_gland1.32293485
66MP0002064_seizures1.32035490
67MP0003119_abnormal_digestive_system1.29486379
68MP0002928_abnormal_bile_duct1.29273618
69MP0002138_abnormal_hepatobiliary_system1.29224692
70MP0003122_maternal_imprinting1.29136840
71MP0004264_abnormal_extraembryonic_tissu1.28679788
72MP0001905_abnormal_dopamine_level1.26741732
73MP0002837_dystrophic_cardiac_calcinosis1.26724378
74MP0001299_abnormal_eye_distance/1.24067943
75MP0001486_abnormal_startle_reflex1.22664729
76MP0000462_abnormal_digestive_system1.22163931
77MP0005386_behavior/neurological_phenoty1.22009232
78MP0004924_abnormal_behavior1.22009232
79MP0002735_abnormal_chemical_nociception1.21946109
80MP0001270_distended_abdomen1.21452584
81MP0005551_abnormal_eye_electrophysiolog1.20873920
82MP0002752_abnormal_somatic_nervous1.19090415
83MP0002152_abnormal_brain_morphology1.17734422
84MP0002009_preneoplasia1.17371296
85MP0000566_synostosis1.16266502
86MP0003861_abnormal_nervous_system1.13562561
87MP0003953_abnormal_hormone_level1.12643679
88MP0000681_abnormal_thyroid_gland1.10721452
89MP0005257_abnormal_intraocular_pressure1.08389292
90MP0001984_abnormal_olfaction1.08119744
91MP0005076_abnormal_cell_differentiation1.04593783
92MP0000778_abnormal_nervous_system1.02848174
93MP0002938_white_spotting1.02572889
94MP0002751_abnormal_autonomic_nervous1.00456645
95MP0001968_abnormal_touch/_nociception0.99918949
96MP0003868_abnormal_feces_composition0.99633834
97MP0000955_abnormal_spinal_cord0.97942140
98MP0005248_abnormal_Harderian_gland0.94178426
99MP0002734_abnormal_mechanical_nocicepti0.92735426
100MP0001765_abnormal_ion_homeostasis0.91380584
101MP0003942_abnormal_urinary_system0.90085730
102MP0005409_darkened_coat_color0.89708737
103MP0003172_abnormal_lysosome_physiology0.89169621
104MP0002254_reproductive_system_inflammat0.88892577
105MP0003045_fibrosis0.88403219
106MP0002184_abnormal_innervation0.88160350
107MP0000026_abnormal_inner_ear0.87508294
108MP0002066_abnormal_motor_capabilities/c0.86955292
109MP0000049_abnormal_middle_ear0.86694251
110MP0005391_vision/eye_phenotype0.86374335
111MP0006276_abnormal_autonomic_nervous0.86283002
112MP0000428_abnormal_craniofacial_morphol0.84774671
113MP0002882_abnormal_neuron_morphology0.84699529
114MP0002557_abnormal_social/conspecific_i0.83644674
115MP0002733_abnormal_thermal_nociception0.83346101
116MP0004858_abnormal_nervous_system0.82116085
117MP0003938_abnormal_ear_development0.81909481
118MP0003011_delayed_dark_adaptation0.81443319
119MP0001501_abnormal_sleep_pattern0.81109451
120MP0003879_abnormal_hair_cell0.80511481
121MP0003959_abnormal_lean_body0.79375516
122MP0002069_abnormal_eating/drinking_beha0.78800175
123MP0009703_decreased_birth_body0.78060486
124MP0005195_abnormal_posterior_eye0.76607345
125MP0009672_abnormal_birth_weight0.76109132
126MP0005448_abnormal_energy_balance0.76006236
127MP0002229_neurodegeneration0.75920240
128MP0004811_abnormal_neuron_physiology0.74936040
129MP0003635_abnormal_synaptic_transmissio0.74494312
130MP0003121_genomic_imprinting0.73704368
131MP0001485_abnormal_pinna_reflex0.73527652
132MP0002177_abnormal_outer_ear0.72404076
133MP0001963_abnormal_hearing_physiology0.70688025
134MP0002102_abnormal_ear_morphology0.69337461
135MP0004885_abnormal_endolymph0.69144322
136MP0008995_early_reproductive_senescence0.67908454
137MP0005535_abnormal_body_temperature0.67830935
138MP0002160_abnormal_reproductive_system0.66364189
139MP0002116_abnormal_craniofacial_bone0.64827637
140MP0003935_abnormal_craniofacial_develop0.64175249
141MP0001286_abnormal_eye_development0.64089749
142MP0000538_abnormal_urinary_bladder0.61785051
143MP0002233_abnormal_nose_morphology0.60710966
144MP0003634_abnormal_glial_cell0.60442742
145MP0000569_abnormal_digit_pigmentation0.60251205
146MP0000639_abnormal_adrenal_gland0.60095807
147MP0005375_adipose_tissue_phenotype0.59976563
148MP0001324_abnormal_eye_pigmentation0.59428144

Predicted human phenotypes

RankGene SetZ-score
1Elevated circulating parathyroid hormone (PTH) level (HP:0003165)6.69491017
2Hyperinsulinemic hypoglycemia (HP:0000825)6.66832768
3Hypoglycemic seizures (HP:0002173)5.80833815
4Symptomatic seizures (HP:0011145)5.38222341
5Insulin-resistant diabetes mellitus (HP:0000831)5.04388920
6Abnormality of calcium-phosphate metabolism (HP:0100530)4.87924040
7Abnormality of endocrine pancreas physiology (HP:0012093)4.48363403
8Abnormality of the pancreatic islet cells (HP:0006476)4.48363403
9Hyperglycemia (HP:0003074)4.39965171
10Pancreatic islet-cell hyperplasia (HP:0004510)4.38681462
11Large for gestational age (HP:0001520)4.19326142
12Myokymia (HP:0002411)3.98153747
13Hypoglycemic coma (HP:0001325)3.91148002
14Unilateral renal agenesis (HP:0000122)3.72307004
15Agitation (HP:0000713)3.68999955
16Ketoacidosis (HP:0001993)3.51975601
17Abnormal pancreas size (HP:0012094)3.42975545
18Neoplasm of the adrenal cortex (HP:0100641)3.26785741
19Late onset (HP:0003584)3.26574181
20Decreased circulating renin level (HP:0003351)3.25445602
21Hypercortisolism (HP:0001578)3.11731313
22Polyphagia (HP:0002591)3.06368180
23Hyperparathyroidism (HP:0000843)3.05879416
24Limb dystonia (HP:0002451)3.02980997
25Papilledema (HP:0001085)2.96881099
26Prominent metopic ridge (HP:0005487)2.93138524
27Progressive cerebellar ataxia (HP:0002073)2.87287836
28Neonatal hypoglycemia (HP:0001998)2.86722424
29Genetic anticipation (HP:0003743)2.86577909
30Hypokalemia (HP:0002900)2.85054025
31Nephronophthisis (HP:0000090)2.83686690
32Abnormality of the metopic suture (HP:0005556)2.77561421
33Hyperthyroidism (HP:0000836)2.75882952
34Hypsarrhythmia (HP:0002521)2.71265217
35EEG with generalized epileptiform discharges (HP:0011198)2.69927972
36Type II diabetes mellitus (HP:0005978)2.68268829
37Mucopolysacchariduria (HP:0008155)2.64468020
38Urinary glycosaminoglycan excretion (HP:0003541)2.64468020
39Diastasis recti (HP:0001540)2.62207687
40Osteomalacia (HP:0002749)2.61712153
41Epileptiform EEG discharges (HP:0011182)2.60524993
42Absent rod-and cone-mediated responses on ERG (HP:0007688)2.58432156
43Epileptic encephalopathy (HP:0200134)2.57350562
44Insulin resistance (HP:0000855)2.57293561
45Metaphyseal dysplasia (HP:0100255)2.56719535
46Retinal atrophy (HP:0001105)2.55128168
47Congenital malformation of the right heart (HP:0011723)2.52949467
48Double outlet right ventricle (HP:0001719)2.52949467
49Abnormality of midbrain morphology (HP:0002418)2.49821248
50Molar tooth sign on MRI (HP:0002419)2.49821248
51Enlarged penis (HP:0000040)2.48482229
52Exocrine pancreatic insufficiency (HP:0001738)2.47535642
53Intestinal atresia (HP:0011100)2.47052619
54Abnormality of polysaccharide metabolism (HP:0011012)2.45272319
55Abnormality of glycosaminoglycan metabolism (HP:0004371)2.45272319
56Abnormality of mucopolysaccharide metabolism (HP:0011020)2.45272319
57Macroorchidism (HP:0000053)2.44089589
58Amblyopia (HP:0000646)2.42596047
59Congenital stationary night blindness (HP:0007642)2.39669315
60Congenital glaucoma (HP:0001087)2.39210553
61Abnormality of potassium homeostasis (HP:0011042)2.38556609
62Abnormality of the renal medulla (HP:0100957)2.37543171
63Abnormal rod and cone electroretinograms (HP:0008323)2.34326417
64Hyperphosphatemia (HP:0002905)2.33901994
65Abnormality of the labia minora (HP:0012880)2.33354338
66Pachygyria (HP:0001302)2.32755409
67Absent eyebrow (HP:0002223)2.32703311
68Adrenal hypoplasia (HP:0000835)2.29964110
69Drooling (HP:0002307)2.29884450
70Focal seizures (HP:0007359)2.27263994
71Medial flaring of the eyebrow (HP:0010747)2.26440261
72Oligodactyly (hands) (HP:0001180)2.25247462
73Hypoplasia of the fovea (HP:0007750)2.23269747
74Aplasia/Hypoplasia of the fovea (HP:0008060)2.23269747
75Abnormality of the gastric mucosa (HP:0004295)2.22732699
76Growth hormone deficiency (HP:0000824)2.22524360
77Abnormality of renin-angiotensin system (HP:0000847)2.22508298
78Posterior subcapsular cataract (HP:0007787)2.22414676
79Poor suck (HP:0002033)2.20440802
80Sleep apnea (HP:0010535)2.19512597
81Insomnia (HP:0100785)2.19348220
82Gait imbalance (HP:0002141)2.18458216
83Menstrual irregularities (HP:0000858)2.18363890
84Shawl scrotum (HP:0000049)2.15959578
85Bony spicule pigmentary retinopathy (HP:0007737)2.15904466
86Papillary thyroid carcinoma (HP:0002895)2.15252143
87Broad-based gait (HP:0002136)2.14160823
88Dysostosis multiplex (HP:0000943)2.13279984
89Fetal akinesia sequence (HP:0001989)2.12427414
90Hyperkalemia (HP:0002153)2.12366437
91Abnormal eating behavior (HP:0100738)2.11878823
92Sex reversal (HP:0012245)2.11327608
93Abnormal sex determination (HP:0012244)2.11327608
94Thoracolumbar scoliosis (HP:0002944)2.10165998
95Abnormality of the fovea (HP:0000493)2.08939809
96Volvulus (HP:0002580)2.08019873
97Restlessness (HP:0000711)2.07459093
98Pancreatic fibrosis (HP:0100732)2.06812720
99Hyperventilation (HP:0002883)2.06154993
100Excessive salivation (HP:0003781)2.05904127
101Hypercalciuria (HP:0002150)2.04080032
102Lissencephaly (HP:0001339)2.03381351
103Rib fusion (HP:0000902)2.02682950
104Failure to thrive in infancy (HP:0001531)2.01387061
105Cystic liver disease (HP:0006706)1.99164818
106Abnormality of the aortic arch (HP:0012303)1.98999887
107Central scotoma (HP:0000603)1.96497634
108Elfin facies (HP:0004428)1.96222244
109Adrenal overactivity (HP:0002717)1.94906245
110Hypogonadotrophic hypogonadism (HP:0000044)1.94141420
111Hypothermia (HP:0002045)1.94114883
112Pheochromocytoma (HP:0002666)1.88045168
113Abnormality of the intervertebral disk (HP:0005108)1.86113448
114Visual hallucinations (HP:0002367)1.85993976
115Febrile seizures (HP:0002373)1.84561912
116Bifid tongue (HP:0010297)1.83836204
117Deep palmar crease (HP:0006191)1.83591792
118Enlarged kidneys (HP:0000105)1.83134238
119Chronic hepatic failure (HP:0100626)1.83111036
120Hemiparesis (HP:0001269)1.82992185
121Type II lissencephaly (HP:0007260)1.82825588
122Spastic tetraplegia (HP:0002510)1.80643290
123Retinal dysplasia (HP:0007973)1.80040003
124Abnormality of the parathyroid morphology (HP:0011766)1.79669208
125Impaired vibration sensation in the lower limbs (HP:0002166)1.78839696
126Conjugated hyperbilirubinemia (HP:0002908)1.77975317
127Congenital primary aphakia (HP:0007707)1.77639065
128Abnormal drinking behavior (HP:0030082)1.77006367
129Polydipsia (HP:0001959)1.77006367
130Increased circulating renin level (HP:0000848)1.76661668
131Abolished electroretinogram (ERG) (HP:0000550)1.75521360
132Narrow forehead (HP:0000341)1.75195985
133Anomalous pulmonary venous return (HP:0010772)1.72973769
134Aplasia/Hypoplasia of the brainstem (HP:0007362)1.72607805
135Hypoplasia of the brainstem (HP:0002365)1.72607805
136Dysautonomia (HP:0002459)1.72190065
137Germ cell neoplasia (HP:0100728)1.71937347
138Hyperacusis (HP:0010780)1.71247701
139Pancreatic cysts (HP:0001737)1.69555849
140Neoplasm of the heart (HP:0100544)1.69113614
141Exotropia (HP:0000577)1.67369993
142Overgrowth (HP:0001548)1.67115528
143Optic nerve hypoplasia (HP:0000609)1.66820781
144Focal motor seizures (HP:0011153)1.66693327
145Nephrogenic diabetes insipidus (HP:0009806)1.66062128
146Hypocalcemia (HP:0002901)1.66059504
147Lip pit (HP:0100267)1.65533403
148Tubular atrophy (HP:0000092)1.65186104
149Esotropia (HP:0000565)1.65088627
150Abnormal hair whorl (HP:0010721)1.65024240
151Abdominal situs inversus (HP:0003363)1.64193856
152Abnormality of abdominal situs (HP:0011620)1.64193856
153Anxiety (HP:0000739)1.62967700
154Hypoplastic female external genitalia (HP:0012815)1.62875103
155Megalencephaly (HP:0001355)1.62618509
156Absent speech (HP:0001344)1.62403452
157Hypotension (HP:0002615)1.59864910
158Truncal obesity (HP:0001956)1.57517813
159Missing ribs (HP:0000921)1.57450123
160Limb hypertonia (HP:0002509)1.55231439
161Postural tremor (HP:0002174)1.54593695
162Abnormality of macular pigmentation (HP:0008002)1.53328533
163Aplasia/Hypoplasia affecting the retina (HP:0008061)1.52248780
164Hepatoblastoma (HP:0002884)1.52239493
165Vertebral arch anomaly (HP:0008438)1.50872039
166Growth hormone excess (HP:0000845)1.49273753
167Hypercalcemia (HP:0003072)1.48359963
168Renal duplication (HP:0000075)1.47857020
169Neuroendocrine neoplasm (HP:0100634)1.47802238
170Testicular neoplasm (HP:0010788)1.47475296
171Obsessive-compulsive behavior (HP:0000722)1.47342127
172Labial hypoplasia (HP:0000066)1.47246224
173Abdominal distention (HP:0003270)1.46986188
174Abnormality of the intrinsic pathway (HP:0010989)1.45963623

Predicted kinase interactions (KEA)

RankGene SetZ-score
1INSRR6.53103693
2PASK4.55771774
3TAOK34.45955312
4HIPK23.61168407
5MAPK152.93686836
6NTRK22.71391823
7MAP3K22.63731881
8PRKD32.52196624
9UHMK12.30921875
10STK162.30291292
11EPHA32.26191085
12NTRK32.02973017
13FRK2.01884619
14IRAK21.95594099
15MAP3K11.83646011
16IRAK11.78668118
17MAP2K71.74099705
18MINK11.62696031
19CDC42BPA1.62330413
20DYRK1B1.62213808
21GRK11.53382190
22TRIB31.51536284
23PRKCG1.50981746
24FGFR21.48454094
25TYRO31.41270514
26ADRBK21.37011712
27CAMK1D1.36465358
28PTK61.33433865
29PDGFRA1.31975622
30MAP3K91.31551743
31PINK11.30972012
32DAPK21.28808826
33SCYL21.25773434
34ERBB31.25217375
35WNK41.23380587
36MAP3K101.20102254
37PRKCH1.18279202
38TNIK1.14113605
39PHKG21.13107466
40PHKG11.13107466
41EPHA41.12872762
42CAMKK21.12465576
43RET1.10208154
44BRD41.08815050
45BCR1.08210825
46NTRK11.02411127
47MARK10.98938884
48BMPR20.97654828
49SGK2230.96097675
50SGK4940.96097675
51MAP2K20.94514246
52CDK190.89509612
53PTK20.88811106
54PAK30.88227850
55MKNK20.87882496
56MAP2K40.87608816
57PRKD20.81274198
58LATS10.79285060
59CAMK40.79259536
60CAMK10.78959872
61AKT30.78506302
62PRKCZ0.77985585
63DYRK30.76530700
64PRKAA10.75925162
65FGFR30.75398156
66CHUK0.72886051
67ERBB20.72600386
68FER0.71477179
69IRAK30.71365903
70TLK10.69714478
71BRSK20.69626342
72WNK30.69383093
73BMPR1B0.69094185
74SIK10.67088984
75MAPK130.65246882
76CAMK1G0.64515889
77ALK0.64233645
78SGK20.63425504
79RPS6KA20.62366125
80CDK30.62191145
81ICK0.61877255
82CSNK1E0.61426098
83JAK20.61063696
84FLT30.60559148
85WNK10.59862248
86SIK20.59231240
87KSR20.58576439
88NLK0.56355139
89DYRK20.55891050
90PRKACA0.54950042
91TAOK10.54475083
92CSNK1A1L0.53550182
93PKN10.53154061
94BRSK10.51622633
95MARK20.49473640
96CSNK1G20.48619616
97CAMK2D0.48410975
98CDK50.47218824
99CAMK2A0.45968675
100SGK30.45683781
101GSK3A0.45642130
102STK110.45534430
103CAMKK10.44284503
104STK390.43756230
105PNCK0.43415153
106MAP3K40.43293830
107MAPK140.43226975
108PRKCE0.43097992
109CSNK1A10.42755699
110PRKDC0.42515354
111CDK140.42388867
112DYRK1A0.42065176
113TESK10.42063985
114RPS6KA60.41254936
115ERN10.40650716
116CASK0.40094244
117KSR10.39805822
118PRKD10.39777138
119ADRBK10.39284429
120RPS6KA30.38885812
121MTOR0.38141194
122FGFR40.37789597
123JAK10.37574228
124CSNK1D0.37403407
125CDK120.37222805
126CAMK2B0.36971737
127PRKG10.36766926
128CDK11A0.36719395
129SGK10.36180555
130GSK3B0.35964448
131CDK150.35895590
132EPHB20.35651508
133PAK60.34964506
134MET0.34652512
135CSNK1G30.34369656
136RPS6KC10.33823492
137RPS6KL10.33823492
138BRAF0.33795895
139GRK50.33116651
140MAPK80.32975726
141AKT10.32850599
142CDK90.32620911
143CDK180.31827626
144MELK0.31573662
145CSNK1G10.30570577
146TAF10.29359338
147MAP3K60.29317481

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049508.27308828
2Nicotine addiction_Homo sapiens_hsa050333.38265365
3Protein export_Homo sapiens_hsa030603.07820630
4Insulin secretion_Homo sapiens_hsa049113.07558383
5Type II diabetes mellitus_Homo sapiens_hsa049303.05810501
6Type I diabetes mellitus_Homo sapiens_hsa049402.41713948
7Protein processing in endoplasmic reticulum_Homo sapiens_hsa041412.38365067
8Sulfur metabolism_Homo sapiens_hsa009202.03952714
9Carbohydrate digestion and absorption_Homo sapiens_hsa049731.89511434
10Cardiac muscle contraction_Homo sapiens_hsa042601.88212383
11Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.85774486
12Cocaine addiction_Homo sapiens_hsa050301.72646512
13Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.66617025
14Oxidative phosphorylation_Homo sapiens_hsa001901.64660005
15Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.63062242
16Butanoate metabolism_Homo sapiens_hsa006501.51646114
17Taste transduction_Homo sapiens_hsa047421.45547576
18Parkinsons disease_Homo sapiens_hsa050121.44010638
19Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.40710529
20Amphetamine addiction_Homo sapiens_hsa050311.36941197
21Phototransduction_Homo sapiens_hsa047441.35381407
22Vibrio cholerae infection_Homo sapiens_hsa051101.34220118
23Dopaminergic synapse_Homo sapiens_hsa047281.32014543
24Cholinergic synapse_Homo sapiens_hsa047251.31925435
25Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.27364075
26Prolactin signaling pathway_Homo sapiens_hsa049171.25068569
27Pancreatic secretion_Homo sapiens_hsa049721.23944263
28N-Glycan biosynthesis_Homo sapiens_hsa005101.21646418
29Basal cell carcinoma_Homo sapiens_hsa052171.16058925
30GABAergic synapse_Homo sapiens_hsa047271.15931941
31Circadian entrainment_Homo sapiens_hsa047131.14921932
32Serotonergic synapse_Homo sapiens_hsa047261.10117846
33Circadian rhythm_Homo sapiens_hsa047101.09709275
34Alzheimers disease_Homo sapiens_hsa050101.05880153
35Synaptic vesicle cycle_Homo sapiens_hsa047211.04738306
36Dorso-ventral axis formation_Homo sapiens_hsa043201.03401581
37Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.00627998
38Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.00206807
39Insulin resistance_Homo sapiens_hsa049310.99834122
40Steroid biosynthesis_Homo sapiens_hsa001000.99748884
41Morphine addiction_Homo sapiens_hsa050320.99703659
42mTOR signaling pathway_Homo sapiens_hsa041500.97332419
43Long-term potentiation_Homo sapiens_hsa047200.95040660
44Estrogen signaling pathway_Homo sapiens_hsa049150.93133675
45Thyroid hormone synthesis_Homo sapiens_hsa049180.92912988
46Aldosterone synthesis and secretion_Homo sapiens_hsa049250.91755390
47Glycosaminoglycan degradation_Homo sapiens_hsa005310.90805894
48Alcoholism_Homo sapiens_hsa050340.88846766
49Olfactory transduction_Homo sapiens_hsa047400.87318958
50Glucagon signaling pathway_Homo sapiens_hsa049220.85168191
51Lysosome_Homo sapiens_hsa041420.84040976
52Glutamatergic synapse_Homo sapiens_hsa047240.83912361
53Longevity regulating pathway - mammal_Homo sapiens_hsa042110.83802929
54Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.83612913
55cGMP-PKG signaling pathway_Homo sapiens_hsa040220.81833711
56Huntingtons disease_Homo sapiens_hsa050160.81147156
57Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.80440638
58Ether lipid metabolism_Homo sapiens_hsa005650.79219581
59Endometrial cancer_Homo sapiens_hsa052130.78915337
60Phosphatidylinositol signaling system_Homo sapiens_hsa040700.77093455
61Selenocompound metabolism_Homo sapiens_hsa004500.76660894
62Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.71962688
63Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.71615249
64Insulin signaling pathway_Homo sapiens_hsa049100.70622632
65Calcium signaling pathway_Homo sapiens_hsa040200.69789673
66Prostate cancer_Homo sapiens_hsa052150.67651412
67Salivary secretion_Homo sapiens_hsa049700.67641623
68Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.67318907
69Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.66982414
70Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.66742585
71Renin secretion_Homo sapiens_hsa049240.66609417
72Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.65900277
73Regulation of autophagy_Homo sapiens_hsa041400.65382191
74Prion diseases_Homo sapiens_hsa050200.65228004
75Ovarian steroidogenesis_Homo sapiens_hsa049130.65069109
76Hippo signaling pathway_Homo sapiens_hsa043900.64329822
77Thyroid hormone signaling pathway_Homo sapiens_hsa049190.63686964
78Hedgehog signaling pathway_Homo sapiens_hsa043400.63329808
79Chronic myeloid leukemia_Homo sapiens_hsa052200.63229760
80Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.63194031
81Dilated cardiomyopathy_Homo sapiens_hsa054140.62523565
82GnRH signaling pathway_Homo sapiens_hsa049120.62397855
83FoxO signaling pathway_Homo sapiens_hsa040680.61749802
84cAMP signaling pathway_Homo sapiens_hsa040240.60973569
85Glioma_Homo sapiens_hsa052140.59945958
86Neurotrophin signaling pathway_Homo sapiens_hsa047220.58795810
87Melanogenesis_Homo sapiens_hsa049160.58406424
88Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.58329350
89ABC transporters_Homo sapiens_hsa020100.58206922
90Notch signaling pathway_Homo sapiens_hsa043300.57095659
91SNARE interactions in vesicular transport_Homo sapiens_hsa041300.56935953
92Renal cell carcinoma_Homo sapiens_hsa052110.55847625
93Tryptophan metabolism_Homo sapiens_hsa003800.55222660
94Inositol phosphate metabolism_Homo sapiens_hsa005620.54392033
95Vascular smooth muscle contraction_Homo sapiens_hsa042700.52729633
96Bile secretion_Homo sapiens_hsa049760.51572914
97Phospholipase D signaling pathway_Homo sapiens_hsa040720.51195687
98Linoleic acid metabolism_Homo sapiens_hsa005910.50355989
99Bladder cancer_Homo sapiens_hsa052190.50305787
100AMPK signaling pathway_Homo sapiens_hsa041520.49324445
101Long-term depression_Homo sapiens_hsa047300.49141362
102alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.47898453
103Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.47502063
104Gap junction_Homo sapiens_hsa045400.47376518
105Ribosome_Homo sapiens_hsa030100.46667073
106Wnt signaling pathway_Homo sapiens_hsa043100.46389886
107Rap1 signaling pathway_Homo sapiens_hsa040150.46165188
108Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.46122791
109VEGF signaling pathway_Homo sapiens_hsa043700.44934574
110MAPK signaling pathway_Homo sapiens_hsa040100.43823545
111Gastric acid secretion_Homo sapiens_hsa049710.43681798
112Sphingolipid metabolism_Homo sapiens_hsa006000.43031239
113Pancreatic cancer_Homo sapiens_hsa052120.42927474
114Collecting duct acid secretion_Homo sapiens_hsa049660.42782284
115ErbB signaling pathway_Homo sapiens_hsa040120.42724437
116Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.42303299
117Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.41526338
118Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.40420031
119Chemokine signaling pathway_Homo sapiens_hsa040620.39570487
120Ras signaling pathway_Homo sapiens_hsa040140.39524073
121Axon guidance_Homo sapiens_hsa043600.39519575
122Colorectal cancer_Homo sapiens_hsa052100.37767870
123Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.37728926
124Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.36595250
125Fatty acid metabolism_Homo sapiens_hsa012120.36449271
126Thyroid cancer_Homo sapiens_hsa052160.36090271
127Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.35431023
128Lysine degradation_Homo sapiens_hsa003100.35419735
129Peroxisome_Homo sapiens_hsa041460.35326060
130Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.35034845
131Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.34968979
132Non-small cell lung cancer_Homo sapiens_hsa052230.34695770
133Oxytocin signaling pathway_Homo sapiens_hsa049210.33293807
134Glycerophospholipid metabolism_Homo sapiens_hsa005640.32307451
135Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.30885310

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