INSRR

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1COPI coating of Golgi vesicle (GO:0048205)8.57036723
2Golgi transport vesicle coating (GO:0048200)8.57036723
3endocrine pancreas development (GO:0031018)7.60696282
4protein maturation by protein folding (GO:0022417)6.68300204
5peptide hormone processing (GO:0016486)6.33223289
6regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022355.84866111
7glandular epithelial cell differentiation (GO:0002067)5.83357506
8regulation of type B pancreatic cell apoptotic process (GO:2000674)5.66592506
9maintenance of protein localization in endoplasmic reticulum (GO:0035437)5.52400188
10insulin secretion (GO:0030073)5.42867004
11type B pancreatic cell development (GO:0003323)5.42607012
12behavioral response to nicotine (GO:0035095)5.41704679
13retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)5.32537150
14multicellular organismal movement (GO:0050879)5.27858180
15musculoskeletal movement (GO:0050881)5.27858180
16COPII vesicle coating (GO:0048208)5.26741717
17glandular epithelial cell development (GO:0002068)5.08833596
18sperm motility (GO:0030317)4.94975259
19signal peptide processing (GO:0006465)4.90942201
20positive regulation of insulin secretion (GO:0032024)4.86176213
21exocrine pancreas development (GO:0031017)4.82058962
22protein retention in ER lumen (GO:0006621)4.81603491
23neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)4.81590083
24response to pheromone (GO:0019236)4.80223887
25microtubule depolymerization (GO:0007019)4.71573809
26sequestering of metal ion (GO:0051238)4.69762036
27cilium or flagellum-dependent cell motility (GO:0001539)4.64767987
28positive regulation of CREB transcription factor activity (GO:0032793)4.57567131
29regulation of insulin secretion (GO:0050796)4.56162433
30detection of calcium ion (GO:0005513)4.55102373
31regulation of somitogenesis (GO:0014807)4.52181555
32enteric nervous system development (GO:0048484)4.47124898
33activation of signaling protein activity involved in unfolded protein response (GO:0006987)4.41283162
34viral protein processing (GO:0019082)4.41243893
35nitric oxide mediated signal transduction (GO:0007263)4.22375238
36regulation of peptide hormone secretion (GO:0090276)4.18570397
37gamma-aminobutyric acid transport (GO:0015812)4.16385279
38acrosome reaction (GO:0007340)4.15358204
39cellular response to vitamin D (GO:0071305)4.14734431
40positive regulation of nuclease activity (GO:0032075)4.14344060
41regulation of peptide secretion (GO:0002791)4.11453525
42microtubule polymerization or depolymerization (GO:0031109)4.07996127
43response to hepatocyte growth factor (GO:0035728)4.04991475
44cellular response to hepatocyte growth factor stimulus (GO:0035729)4.04991475
45ER overload response (GO:0006983)4.04723915
46NAD biosynthetic process (GO:0009435)4.03665457
47positive regulation of synapse maturation (GO:0090129)4.03426986
48negative regulation of translation involved in gene silencing by miRNA (GO:0035278)4.01302523
49negative regulation of translation, ncRNA-mediated (GO:0040033)4.01302523
50regulation of translation, ncRNA-mediated (GO:0045974)4.01302523
51columnar/cuboidal epithelial cell development (GO:0002066)4.00249933
52fusion of sperm to egg plasma membrane (GO:0007342)3.96787084
53positive regulation of peptide hormone secretion (GO:0090277)3.94229666
54negative regulation of glycoprotein biosynthetic process (GO:0010561)3.91385306
55vesicle coating (GO:0006901)3.90849125
56cranial nerve morphogenesis (GO:0021602)3.87860314
57peptide hormone secretion (GO:0030072)3.86060060
58positive regulation of peptide secretion (GO:0002793)3.82537333
59peptide secretion (GO:0002790)3.77744768
60regulation of nuclease activity (GO:0032069)3.76130088
61nephron tubule morphogenesis (GO:0072078)3.75240514
62nephron epithelium morphogenesis (GO:0072088)3.75240514
63spinal cord motor neuron differentiation (GO:0021522)3.74682728
64negative regulation of insulin secretion (GO:0046676)3.74061255
65behavioral response to ethanol (GO:0048149)3.72961820
66negative regulation of norepinephrine secretion (GO:0010700)3.68653266
67axonemal dynein complex assembly (GO:0070286)3.68321834
68regulation of hormone secretion (GO:0046883)3.68118104
69endoplasmic reticulum unfolded protein response (GO:0030968)3.63602591
70neuromuscular synaptic transmission (GO:0007274)3.59717473
71cellular response to unfolded protein (GO:0034620)3.57707302
72calcium ion-dependent exocytosis (GO:0017156)3.53611590
73protein polyglutamylation (GO:0018095)3.53136381
74intra-Golgi vesicle-mediated transport (GO:0006891)3.47590700
75cellular response to topologically incorrect protein (GO:0035967)3.47313031
76ER-nucleus signaling pathway (GO:0006984)3.43492679
77negative regulation of catecholamine secretion (GO:0033604)3.41645008
78postsynaptic membrane organization (GO:0001941)3.41101764
79somite development (GO:0061053)3.40328469
80peristalsis (GO:0030432)3.38303644
81regulation of synapse maturation (GO:0090128)3.37711643
82inner ear receptor cell development (GO:0060119)3.36599607
83regulation of peptide transport (GO:0090087)3.36457974
84toxin metabolic process (GO:0009404)3.35011413
85vocalization behavior (GO:0071625)3.34896704
86astrocyte differentiation (GO:0048708)3.31140193
87protein localization to Golgi apparatus (GO:0034067)3.29156585
88negative regulation of peptide hormone secretion (GO:0090278)3.27328255
89regulation of glucokinase activity (GO:0033131)3.26471207
90regulation of hexokinase activity (GO:1903299)3.26471207
91positive regulation of sodium ion transmembrane transporter activity (GO:2000651)3.25728499
92multicellular organism reproduction (GO:0032504)3.25430354
93ER-associated ubiquitin-dependent protein catabolic process (GO:0030433)3.25310649
94regulation of glucocorticoid secretion (GO:2000849)3.24839736
95negative regulation of adenylate cyclase activity (GO:0007194)3.22993471
96chemosensory behavior (GO:0007635)3.21563069
97virion assembly (GO:0019068)3.21274173
98positive regulation of hormone secretion (GO:0046887)3.20740618
99membrane depolarization during action potential (GO:0086010)3.17991602
100negative regulation of peptide secretion (GO:0002792)3.15219311
101sperm capacitation (GO:0048240)3.14438244
102epithelial cell fate commitment (GO:0072148)3.13270692
103ventricular system development (GO:0021591)3.12742288
104L-alpha-amino acid transmembrane transport (GO:1902475)3.12625320
105sympathetic nervous system development (GO:0048485)3.12603709
106metanephric nephron tubule development (GO:0072234)3.11958545
107metanephric tubule development (GO:0072170)3.11958545
108negative regulation of bone resorption (GO:0045779)3.11277145
109auditory behavior (GO:0031223)3.10824204
110regulation of histone phosphorylation (GO:0033127)3.10230191
111alanine transport (GO:0032328)3.09945459
112regulation of energy homeostasis (GO:2000505)3.09640359
113hormone secretion (GO:0046879)3.09360095
114pyridine nucleotide biosynthetic process (GO:0019363)3.09089133
115nicotinamide nucleotide biosynthetic process (GO:0019359)3.09089133
116cellular zinc ion homeostasis (GO:0006882)3.07915486
117negative regulation of cyclase activity (GO:0031280)3.06873822
118behavioral response to pain (GO:0048266)3.05576801
119response to hexose (GO:0009746)3.03615529
120peptide transport (GO:0015833)3.03584514
121epithelial cell maturation (GO:0002070)3.03366427
122hindbrain development (GO:0030902)3.03127525
123tRNA methylation (GO:0030488)3.02446734
124phenol-containing compound catabolic process (GO:0019336)3.02408939
125protein N-linked glycosylation via asparagine (GO:0018279)3.01712473
126nucleoside diphosphate catabolic process (GO:0009134)3.01554938
127protein localization to synapse (GO:0035418)3.00995832
128transmission of nerve impulse (GO:0019226)2.99786968
129chromatin silencing (GO:0006342)2.99710771
130response to glucose (GO:0009749)2.99222224
131peptidyl-asparagine modification (GO:0018196)2.98139253
132neuron cell-cell adhesion (GO:0007158)2.97710480
133reflex (GO:0060004)2.96020817
134cell differentiation in hindbrain (GO:0021533)2.93268372
135negative regulation of glycoprotein metabolic process (GO:1903019)2.93138975
136microtubule severing (GO:0051013)2.93112622
137hormone transport (GO:0009914)2.91023021
138interleukin-1-mediated signaling pathway (GO:0070498)2.89377939
139response to endoplasmic reticulum stress (GO:0034976)2.89209490
140tongue development (GO:0043586)2.89019086
141spinal cord development (GO:0021510)2.89018208
142positive regulation of fatty acid beta-oxidation (GO:0032000)2.88538009
143response to monosaccharide (GO:0034284)2.87635835
144catecholamine biosynthetic process (GO:0042423)2.86110206
145catechol-containing compound biosynthetic process (GO:0009713)2.86110206
146regulation of transcription involved in cell fate commitment (GO:0060850)2.86037540
147glucose homeostasis (GO:0042593)2.85606944
148carbohydrate homeostasis (GO:0033500)2.85606944
149renal tubule morphogenesis (GO:0061333)2.84772015
150lung epithelium development (GO:0060428)2.82818633
151negative regulation of lyase activity (GO:0051350)2.81392916
152collecting duct development (GO:0072044)2.80382121
153negative regulation of calcium ion-dependent exocytosis (GO:0045955)2.79624104
154plasma membrane fusion (GO:0045026)2.78916499
155ER to Golgi vesicle-mediated transport (GO:0006888)2.78346830
156negative regulation of cytosolic calcium ion concentration (GO:0051481)2.76566872
157cellular response to glucagon stimulus (GO:0071377)2.76116068
158face development (GO:0060324)2.75930061
159protein N-linked glycosylation (GO:0006487)2.75743037
160response to auditory stimulus (GO:0010996)2.75429311
161eosinophil chemotaxis (GO:0048245)2.75202305
162pancreas development (GO:0031016)2.74517827
163gonadal mesoderm development (GO:0007506)2.73247220
164retina layer formation (GO:0010842)2.72972778
165cell differentiation in spinal cord (GO:0021515)2.72143025
166regulation of insulin secretion involved in cellular response to glucose stimulus (GO:0061178)2.71310151
167regulation of cardioblast proliferation (GO:0003264)2.70612403
168regulation of secondary heart field cardioblast proliferation (GO:0003266)2.70612403
169regulation of corticosteroid hormone secretion (GO:2000846)2.70562601
170regulation of female gonad development (GO:2000194)2.70204222
171definitive hemopoiesis (GO:0060216)2.70126602
1723-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.69565734
173purine ribonucleoside bisphosphate metabolic process (GO:0034035)2.69565734
174calcium ion import (GO:0070509)2.69455830
175macroautophagy (GO:0016236)2.69148387
176intestinal epithelial cell development (GO:0060576)2.69141536
177negative regulation of cAMP biosynthetic process (GO:0030818)2.68900591
178metanephric nephron epithelium development (GO:0072243)2.68217695
179neurotransmitter-gated ion channel clustering (GO:0072578)2.67935537
180urinary tract smooth muscle contraction (GO:0014848)2.66802139
181cerebellar Purkinje cell differentiation (GO:0021702)2.66532688
182chromosome condensation (GO:0030261)2.64947731
183protein K48-linked deubiquitination (GO:0071108)2.61856491
184detection of mechanical stimulus (GO:0050982)2.60928275
185sperm-egg recognition (GO:0035036)2.60926109
186spermatid development (GO:0007286)2.59543793
187negative regulation of cyclic nucleotide biosynthetic process (GO:0030803)2.58501256
188negative regulation of smooth muscle cell differentiation (GO:0051151)2.54601533
189male gamete generation (GO:0048232)2.54189358
190spermatogenesis (GO:0007283)2.54053507
191cerebellar granule cell differentiation (GO:0021707)2.53139956
192reproduction (GO:0000003)2.52702608
193establishment of protein localization to Golgi (GO:0072600)2.52694198
194positive regulation of fatty acid oxidation (GO:0046321)2.51352468
195regulation of dopamine uptake involved in synaptic transmission (GO:0051584)2.51169129
196regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)2.51169129
197neural tube development (GO:0021915)2.51165370
198proline transport (GO:0015824)2.51063913
199cranial nerve development (GO:0021545)2.50819989

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse7.15495168
2EZH2_22144423_ChIP-Seq_EOC_Human4.04039756
3TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.35784020
4GBX2_23144817_ChIP-Seq_PC3_Human2.91144973
5IGF1R_20145208_ChIP-Seq_DFB_Human2.77376443
6GATA1_22025678_ChIP-Seq_K562_Human2.36802722
7GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.35755493
8DMRT1_21621532_ChIP-ChIP_FETAL_Ovary2.28949234
9EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.23252167
10REST_21632747_ChIP-Seq_MESCs_Mouse2.21370699
11ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.19278033
12CBX2_27304074_Chip-Seq_ESCs_Mouse2.09497432
13PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.05873911
14AR_21572438_ChIP-Seq_LNCaP_Human2.01730786
15MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.00104284
16STAT6_21828071_ChIP-Seq_BEAS2B_Human1.97795091
17* BMI1_23680149_ChIP-Seq_NPCS_Mouse1.91288339
18EZH2_27304074_Chip-Seq_ESCs_Mouse1.86950988
19* SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.85505732
20* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.83821363
21* SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.82249497
22CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.78886223
23MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.77562214
24CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.72306867
25POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.68921587
26TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.68921587
27* JARID2_20075857_ChIP-Seq_MESCs_Mouse1.64492162
28GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.64078912
29NR3C1_23031785_ChIP-Seq_PC12_Mouse1.63602658
30* EZH2_27294783_Chip-Seq_ESCs_Mouse1.61795448
31ZNF274_21170338_ChIP-Seq_K562_Hela1.61590904
32TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.61492626
33PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.57213369
34* JARID2_20064375_ChIP-Seq_MESCs_Mouse1.57200528
35REST_18959480_ChIP-ChIP_MESCs_Mouse1.54286787
36* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.53229147
37SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.52396355
38OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.50916508
39EED_16625203_ChIP-ChIP_MESCs_Mouse1.50730199
40SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.50041096
41PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.49835282
42PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.49150836
43STAT3_23295773_ChIP-Seq_U87_Human1.48904336
44* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.48334049
45VDR_22108803_ChIP-Seq_LS180_Human1.47272031
46PIAS1_25552417_ChIP-Seq_VCAP_Human1.46739603
47RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.46053460
48POU3F2_20337985_ChIP-ChIP_501MEL_Human1.45437712
49* SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.44652071
50WDR5_24793694_ChIP-Seq_LNCAP_Human1.44129467
51ZFP57_27257070_Chip-Seq_ESCs_Mouse1.43809034
52SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.38460732
53CTBP2_25329375_ChIP-Seq_LNCAP_Human1.35802044
54ERG_21242973_ChIP-ChIP_JURKAT_Human1.33884631
55SMAD4_21799915_ChIP-Seq_A2780_Human1.31945262
56ZNF217_24962896_ChIP-Seq_MCF-7_Human1.29608616
57FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.28453336
58VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.28351075
59NANOG_18555785_Chip-Seq_ESCs_Mouse1.26183683
60RNF2_27304074_Chip-Seq_ESCs_Mouse1.24327577
61RNF2_18974828_ChIP-Seq_MESCs_Mouse1.23611579
62EZH2_18974828_ChIP-Seq_MESCs_Mouse1.23611579
63DROSHA_22980978_ChIP-Seq_HELA_Human1.22843816
64BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.22326755
65SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.21777798
66NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.21347972
67BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.20976748
68* CTCF_27219007_Chip-Seq_Bcells_Human1.20165341
69ER_23166858_ChIP-Seq_MCF-7_Human1.19453656
70OCT1_27270436_Chip-Seq_PROSTATE_Human1.18393432
71CDX2_19796622_ChIP-Seq_MESCs_Mouse1.16292422
72AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.15965945
73LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.15257754
74TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.15142053
75STAT3_18555785_Chip-Seq_ESCs_Mouse1.13769377
76* FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.13324658
77EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.13272526
78SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.13073346
79NR3C1_21868756_ChIP-Seq_MCF10A_Human1.13048064
80EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.12816129
81ERA_21632823_ChIP-Seq_H3396_Human1.11934987
82TP63_19390658_ChIP-ChIP_HaCaT_Human1.11429300
83OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.10999278
84OCT4_20526341_ChIP-Seq_ESCs_Human1.10984102
85TP53_20018659_ChIP-ChIP_R1E_Mouse1.10391536
86BCAT_22108803_ChIP-Seq_LS180_Human1.10084733
87GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.08925193
88RING1B_27294783_Chip-Seq_NPCs_Mouse1.08255738
89P300_19829295_ChIP-Seq_ESCs_Human1.07570232
90YAP1_20516196_ChIP-Seq_MESCs_Mouse1.07376846
91TOP2B_26459242_ChIP-Seq_MCF-7_Human1.07016137
92SMAD4_21741376_ChIP-Seq_HESCs_Human1.06876120
93OCT4_19829295_ChIP-Seq_ESCs_Human1.06674485
94CBP_20019798_ChIP-Seq_JUKART_Human1.06531952
95IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.06531952
96IKZF1_21737484_ChIP-ChIP_HCT116_Human1.06041049
97RARB_27405468_Chip-Seq_BRAIN_Mouse1.05659170
98P53_22387025_ChIP-Seq_ESCs_Mouse1.05517338
99UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.05515781
100REST_19997604_ChIP-ChIP_NEURONS_Mouse1.05223835
101KDM2B_26808549_Chip-Seq_REH_Human1.05011222
102ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.04994040
103EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.04405461
104* GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.01410456
105SOX2_21211035_ChIP-Seq_LN229_Gbm1.01252760
106RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.01175383
107TCF4_23295773_ChIP-Seq_U87_Human1.00354981
108NMYC_18555785_Chip-Seq_ESCs_Mouse1.00199317
109SMAD3_21741376_ChIP-Seq_ESCs_Human1.00119926
110MYC_19829295_ChIP-Seq_ESCs_Human0.99675367
111ARNT_22903824_ChIP-Seq_MCF-7_Human0.99341378
112SMAD3_21741376_ChIP-Seq_EPCs_Human0.99091748
113SMC4_20622854_ChIP-Seq_HELA_Human0.99043830
114SMAD4_21741376_ChIP-Seq_EPCs_Human0.98526929
115ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.98321512
116E2F1_20622854_ChIP-Seq_HELA_Human0.98152741
117AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.97986891
118SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.97637182
119TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.97512436
120AR_25329375_ChIP-Seq_VCAP_Human0.97059963
121RUNX2_22187159_ChIP-Seq_PCA_Human0.96698001
122RING1B_27294783_Chip-Seq_ESCs_Mouse0.96444160
123ESR1_21235772_ChIP-Seq_MCF-7_Human0.95375286
124TBL1_22424771_ChIP-Seq_293T_Human0.95262569
125FUS_26573619_Chip-Seq_HEK293_Human0.95059124
126SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.94049844
127ELK4_26923725_Chip-Seq_MESODERM_Mouse0.93741775
128TAF2_19829295_ChIP-Seq_ESCs_Human0.93077633
129CTCF_20526341_ChIP-Seq_ESCs_Human0.92945471
130WT1_25993318_ChIP-Seq_PODOCYTE_Human0.92778481
131SOX2_27498859_Chip-Seq_STOMACH_Mouse0.92731581
132MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.92029056
133TP53_22573176_ChIP-Seq_HFKS_Human0.91895709
134WT1_19549856_ChIP-ChIP_CCG9911_Human0.91884032
135RUNX1_26923725_Chip-Seq_HPCs_Mouse0.91577086
136PHF8_20622854_ChIP-Seq_HELA_Human0.91493851
137GF1_26923725_Chip-Seq_HPCs_Mouse0.91263410
138RAC3_21632823_ChIP-Seq_H3396_Human0.91099844
139CTBP1_25329375_ChIP-Seq_LNCAP_Human0.91020636
140FOXA1_25552417_ChIP-Seq_VCAP_Human0.90830077
141CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.90769313
142RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.90552909
143TAL1_26923725_Chip-Seq_HPCs_Mouse0.90227779
144RNF2_27304074_Chip-Seq_NSC_Mouse0.90135896
145AR_19668381_ChIP-Seq_PC3_Human0.89684020
146ESRRB_18555785_Chip-Seq_ESCs_Mouse0.89620030
147PCGF2_27294783_Chip-Seq_NPCs_Mouse0.88771083
148VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.88724839
149CMYC_18555785_Chip-Seq_ESCs_Mouse0.88622829
150SOX2_18555785_Chip-Seq_ESCs_Mouse0.88500949
151FLI1_21867929_ChIP-Seq_TH2_Mouse0.88126183
152TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.87860866
153SUZ12_18555785_Chip-Seq_ESCs_Mouse0.87812466
154SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.86116456
155* GF1B_26923725_Chip-Seq_HPCs_Mouse0.85363663
156PCGF2_27294783_Chip-Seq_ESCs_Mouse0.85145449

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003878_abnormal_ear_physiology5.76208970
2MP0005377_hearing/vestibular/ear_phenot5.76208970
3MP0003283_abnormal_digestive_organ5.28375090
4MP0002877_abnormal_melanocyte_morpholog5.08662917
5MP0002822_catalepsy4.81570877
6MP0002693_abnormal_pancreas_physiology4.52382961
7MP0004043_abnormal_pH_regulation4.49863169
8MP0001944_abnormal_pancreas_morphology3.81958949
9MP0003195_calcinosis3.81755451
10MP0009780_abnormal_chondrocyte_physiolo3.70135004
11MP0002909_abnormal_adrenal_gland3.64940045
12MP0006292_abnormal_olfactory_placode3.59412946
13MP0010386_abnormal_urinary_bladder3.54008145
14MP0000678_abnormal_parathyroid_gland3.52982170
15MP0005379_endocrine/exocrine_gland_phen3.52612927
16MP0000013_abnormal_adipose_tissue3.07547041
17MP0005410_abnormal_fertilization2.98665178
18MP0001485_abnormal_pinna_reflex2.61327069
19MP0003183_abnormal_peptide_metabolism2.57135344
20MP0002249_abnormal_larynx_morphology2.53196886
21MP0005220_abnormal_exocrine_pancreas2.45133908
22MP0005646_abnormal_pituitary_gland2.43538241
23MP0006072_abnormal_retinal_apoptosis2.42564717
24MP0002078_abnormal_glucose_homeostasis2.30602259
25MP0002837_dystrophic_cardiac_calcinosis2.27924780
26MP0002735_abnormal_chemical_nociception2.23595478
27MP0001986_abnormal_taste_sensitivity2.13297334
28MP0002638_abnormal_pupillary_reflex2.12646748
29MP0001968_abnormal_touch/_nociception2.06086242
30MP0005645_abnormal_hypothalamus_physiol2.02222172
31MP0003646_muscle_fatigue2.01187332
32MP0001486_abnormal_startle_reflex2.00267085
33MP0002653_abnormal_ependyma_morphology1.84888815
34MP0005167_abnormal_blood-brain_barrier1.80685903
35MP0000462_abnormal_digestive_system1.79098402
36MP0005503_abnormal_tendon_morphology1.77401980
37MP0005257_abnormal_intraocular_pressure1.65550535
38MP0000003_abnormal_adipose_tissue1.65057325
39MP0009046_muscle_twitch1.61486380
40MP0008995_early_reproductive_senescence1.60213707
41MP0003698_abnormal_male_reproductive1.58974475
42MP0004270_analgesia1.55861188
43MP0004264_abnormal_extraembryonic_tissu1.55561789
44MP0001765_abnormal_ion_homeostasis1.54888715
45MP0003122_maternal_imprinting1.52222064
46MP0002928_abnormal_bile_duct1.51143292
47MP0002896_abnormal_bone_mineralization1.50942827
48MP0002234_abnormal_pharynx_morphology1.50840365
49MP0008872_abnormal_physiological_respon1.49064902
50MP0002876_abnormal_thyroid_physiology1.48988498
51MP0003136_yellow_coat_color1.47837636
52MP0003953_abnormal_hormone_level1.41725677
53MP0009745_abnormal_behavioral_response1.41374725
54MP0003868_abnormal_feces_composition1.40596196
55MP0000631_abnormal_neuroendocrine_gland1.39586390
56MP0003300_gastrointestinal_ulcer1.37253334
57MP0000613_abnormal_salivary_gland1.34315309
58MP0002163_abnormal_gland_morphology1.30774566
59MP0003172_abnormal_lysosome_physiology1.30174363
60MP0002063_abnormal_learning/memory/cond1.30033600
61MP0001270_distended_abdomen1.29390693
62MP0005310_abnormal_salivary_gland1.27341507
63MP0005083_abnormal_biliary_tract1.25361869
64MP0004859_abnormal_synaptic_plasticity1.23839633
65MP0001929_abnormal_gametogenesis1.23256802
66MP0009278_abnormal_bone_marrow1.20983790
67MP0001963_abnormal_hearing_physiology1.20228800
68MP0002067_abnormal_sensory_capabilities1.19088680
69MP0005253_abnormal_eye_physiology1.19027980
70MP0003119_abnormal_digestive_system1.16376342
71MP0000026_abnormal_inner_ear1.13602228
72MP0008961_abnormal_basal_metabolism1.11525575
73MP0002064_seizures1.10287703
74MP0005535_abnormal_body_temperature1.09621015
75MP0004142_abnormal_muscle_tone1.08222686
76MP0001661_extended_life_span1.02708781
77MP0000427_abnormal_hair_cycle1.00449863
78MP0009643_abnormal_urine_homeostasis0.99480567
79MP0001502_abnormal_circadian_rhythm0.96929608
80MP0002138_abnormal_hepatobiliary_system0.96791662
81MP0004145_abnormal_muscle_electrophysio0.96706189
82MP0003787_abnormal_imprinting0.95703350
83MP0002736_abnormal_nociception_after0.95668810
84MP0001905_abnormal_dopamine_level0.94266413
85MP0001299_abnormal_eye_distance/0.94160208
86MP0005386_behavior/neurological_phenoty0.92359984
87MP0004924_abnormal_behavior0.92359984
88MP0002882_abnormal_neuron_morphology0.90706516
89MP0000681_abnormal_thyroid_gland0.89200689
90MP0002184_abnormal_innervation0.88640215
91MP0000733_abnormal_muscle_development0.87958593
92MP0000534_abnormal_ureter_morphology0.86646792
93MP0005423_abnormal_somatic_nervous0.86402277
94MP0003115_abnormal_respiratory_system0.86284236
95MP0004130_abnormal_muscle_cell0.84389805
96MP0000470_abnormal_stomach_morphology0.83186657
97MP0003252_abnormal_bile_duct0.82914901
98MP0005076_abnormal_cell_differentiation0.82356750
99MP0002932_abnormal_joint_morphology0.81768854
100MP0002161_abnormal_fertility/fecundity0.81651377
101MP0003632_abnormal_nervous_system0.81479100
102MP0003045_fibrosis0.80776535
103MP0000230_abnormal_systemic_arterial0.80059350
104MP0003959_abnormal_lean_body0.79030301
105MP0005636_abnormal_mineral_homeostasis0.78787560
106MP0002733_abnormal_thermal_nociception0.77528909
107MP0002210_abnormal_sex_determination0.77302486
108MP0002752_abnormal_somatic_nervous0.77182371
109MP0001756_abnormal_urination0.76412565
110MP0000049_abnormal_middle_ear0.75935122
111MP0005448_abnormal_energy_balance0.75421633
112MP0005670_abnormal_white_adipose0.74938417
113MP0000955_abnormal_spinal_cord0.74133194
114MP0002734_abnormal_mechanical_nocicepti0.73971912
115MP0002108_abnormal_muscle_morphology0.72516031
116MP0003879_abnormal_hair_cell0.72314857
117MP0004742_abnormal_vestibular_system0.71567106
118MP0000538_abnormal_urinary_bladder0.71339286
119MP0008057_abnormal_DNA_replication0.71302759
120MP0003890_abnormal_embryonic-extraembry0.71200666
121MP0001188_hyperpigmentation0.70744264
122MP0002177_abnormal_outer_ear0.68937717
123MP0000428_abnormal_craniofacial_morphol0.68820679
124MP0005266_abnormal_metabolism0.68315466
125MP0003635_abnormal_synaptic_transmissio0.67746059
126MP0005375_adipose_tissue_phenotype0.67676440
127MP0002102_abnormal_ear_morphology0.67278307
128MP0003866_abnormal_defecation0.67164838
129MP0006138_congestive_heart_failure0.66756903
130MP0003861_abnormal_nervous_system0.66626981
131MP0001664_abnormal_digestion0.65624537
132MP0002938_white_spotting0.64962867
133MP0001440_abnormal_grooming_behavior0.64446291
134MP0002751_abnormal_autonomic_nervous0.62692715
135MP0002557_abnormal_social/conspecific_i0.62066147
136MP0009672_abnormal_birth_weight0.61080730
137MP0000566_synostosis0.60945535
138MP0001348_abnormal_lacrimal_gland0.60938192
139MP0002069_abnormal_eating/drinking_beha0.60882877
140MP0000639_abnormal_adrenal_gland0.60343914
141MP0006276_abnormal_autonomic_nervous0.59598104
142MP0005187_abnormal_penis_morphology0.58938273
143MP0005365_abnormal_bile_salt0.58852136
144MP0002572_abnormal_emotion/affect_behav0.58426080
145MP0001970_abnormal_pain_threshold0.57442462
146MP0001984_abnormal_olfaction0.56700995
147MP0002272_abnormal_nervous_system0.53357489
148MP0005058_abnormal_lysosome_morphology0.53181581
149MP0002229_neurodegeneration0.52930028
150MP0009703_decreased_birth_body0.52121477
151MP0000163_abnormal_cartilage_morphology0.51471068
152MP0001731_abnormal_postnatal_growth0.49102870
153MP0005334_abnormal_fat_pad0.47870283
154MP0004185_abnormal_adipocyte_glucose0.47683997
155MP0001501_abnormal_sleep_pattern0.45600683
156MP0005551_abnormal_eye_electrophysiolog0.45403367
157MP0002168_other_aberrant_phenotype0.44950582

Predicted human phenotypes

RankGene SetZ-score
1Hyperinsulinemic hypoglycemia (HP:0000825)8.97174219
2Hypoglycemic seizures (HP:0002173)7.78737027
3Symptomatic seizures (HP:0011145)7.62372841
4Elevated circulating parathyroid hormone (PTH) level (HP:0003165)7.47387641
5Hypoglycemic coma (HP:0001325)6.40120963
6Genetic anticipation (HP:0003743)6.19117958
7Insulin-resistant diabetes mellitus (HP:0000831)5.72180787
8Hyperglycemia (HP:0003074)5.10698019
9Abnormality of calcium-phosphate metabolism (HP:0100530)4.92898950
10Pancreatic islet-cell hyperplasia (HP:0004510)4.86989329
11Abnormality of the pancreatic islet cells (HP:0006476)4.62573429
12Abnormality of endocrine pancreas physiology (HP:0012093)4.62573429
13Large for gestational age (HP:0001520)4.62496775
14Aplasia/Hypoplasia of the pubic bone (HP:0009104)4.61372775
15Decreased circulating renin level (HP:0003351)4.50726678
16Protruding tongue (HP:0010808)4.33244116
17Progressive cerebellar ataxia (HP:0002073)4.30899701
18Ketoacidosis (HP:0001993)4.28278872
19Hypoplastic ischia (HP:0003175)4.20525223
20Birth length less than 3rd percentile (HP:0003561)4.16477777
21Abnormal pancreas size (HP:0012094)4.05184220
22Osteomalacia (HP:0002749)3.89410667
23Late onset (HP:0003584)3.88947106
24Hyperventilation (HP:0002883)3.84582094
25Generalized aminoaciduria (HP:0002909)3.81566532
26Abnormality of the ischium (HP:0003174)3.66786029
27Hypokalemia (HP:0002900)3.61297567
28Abnormality of the pubic bones (HP:0003172)3.56775670
29Attenuation of retinal blood vessels (HP:0007843)3.54149841
30Bell-shaped thorax (HP:0001591)3.53805257
31Chronic hepatic failure (HP:0100626)3.44418851
32Breast hypoplasia (HP:0003187)3.37009415
33Abnormality of renin-angiotensin system (HP:0000847)3.27066357
34Hypothermia (HP:0002045)3.26750591
35Mucopolysacchariduria (HP:0008155)3.19378172
36Urinary glycosaminoglycan excretion (HP:0003541)3.19378172
37Abnormality of binocular vision (HP:0011514)3.08888900
38Diplopia (HP:0000651)3.08888900
39Prominent metopic ridge (HP:0005487)3.03189733
40Hypoplasia of the fovea (HP:0007750)3.00231762
41Aplasia/Hypoplasia of the fovea (HP:0008060)3.00231762
42Abnormality of mucopolysaccharide metabolism (HP:0011020)3.00148287
43Abnormality of polysaccharide metabolism (HP:0011012)3.00148287
44Abnormality of glycosaminoglycan metabolism (HP:0004371)3.00148287
45Insulin resistance (HP:0000855)2.94327189
46Abnormality of potassium homeostasis (HP:0011042)2.94259010
47Retinal dysplasia (HP:0007973)2.92555503
48Patellar aplasia (HP:0006443)2.91664964
49Clumsiness (HP:0002312)2.91657214
50Hyperactive renin-angiotensin system (HP:0000841)2.90424385
51Unilateral renal agenesis (HP:0000122)2.89862618
52Dysostosis multiplex (HP:0000943)2.88273417
53Hyperparathyroidism (HP:0000843)2.80128333
54Conjugated hyperbilirubinemia (HP:0002908)2.75531050
55Agitation (HP:0000713)2.75265467
56Cystic liver disease (HP:0006706)2.73756740
57Tracheomalacia (HP:0002779)2.73504744
58Abnormality of the metopic suture (HP:0005556)2.70269363
59Hyperkalemia (HP:0002153)2.70129104
60Nephronophthisis (HP:0000090)2.63406798
61Aplasia/Hypoplasia of the patella (HP:0006498)2.58979582
62Abnormality of the fovea (HP:0000493)2.55870502
63Abnormal respiratory motile cilium morphology (HP:0005938)2.51654171
64Abnormal respiratory epithelium morphology (HP:0012253)2.51654171
65Increased circulating renin level (HP:0000848)2.47510436
66Renovascular hypertension (HP:0100817)2.46904456
67EEG with generalized epileptiform discharges (HP:0011198)2.46520350
68Abnormality of the columella (HP:0009929)2.45333903
69Gaze-evoked nystagmus (HP:0000640)2.43746472
70Abnormality of the intrinsic pathway (HP:0010989)2.41694551
71Hypophosphatemia (HP:0002148)2.40397924
72Epileptiform EEG discharges (HP:0011182)2.39498766
73Impaired smooth pursuit (HP:0007772)2.39042853
74Bronchomalacia (HP:0002780)2.38770701
75Long eyelashes (HP:0000527)2.38402540
76Hypsarrhythmia (HP:0002521)2.35857810
77Visual hallucinations (HP:0002367)2.29358902
78Morphological abnormality of the middle ear (HP:0008609)2.27592506
79Ketosis (HP:0001946)2.27580309
80Abnormality of the fingertips (HP:0001211)2.26414347
81Bony spicule pigmentary retinopathy (HP:0007737)2.25208672
82Limb hypertonia (HP:0002509)2.25136735
83Retinal atrophy (HP:0001105)2.22503400
84Absent/shortened dynein arms (HP:0200106)2.21793435
85Dynein arm defect of respiratory motile cilia (HP:0012255)2.21793435
86Exotropia (HP:0000577)2.21752761
87Bilateral microphthalmos (HP:0007633)2.20214201
88Thoracolumbar scoliosis (HP:0002944)2.19989397
89Tubulointerstitial nephritis (HP:0001970)2.18143625
90Congenital stationary night blindness (HP:0007642)2.18031266
91Hypoplastic labia majora (HP:0000059)2.17757130
92Midline defect of the nose (HP:0004122)2.17657414
93Abnormality of the renal medulla (HP:0100957)2.17396296
94Cerebral aneurysm (HP:0004944)2.16395255
95Tented upper lip vermilion (HP:0010804)2.15230575
96Urethral obstruction (HP:0000796)2.13847310
97Recurrent corneal erosions (HP:0000495)2.12092802
98Cutaneous finger syndactyly (HP:0010554)2.10397811
99Abdominal distention (HP:0003270)2.08696179
100Neoplasm of the heart (HP:0100544)2.07759401
101Cortical visual impairment (HP:0100704)2.07461653
102Chronic bronchitis (HP:0004469)2.06368195
103Intestinal atresia (HP:0011100)2.05889896
104Severe visual impairment (HP:0001141)2.05261686
105Molar tooth sign on MRI (HP:0002419)2.02466164
106Abnormality of midbrain morphology (HP:0002418)2.02466164
107Polydipsia (HP:0001959)2.02362864
108Abnormal drinking behavior (HP:0030082)2.02362864
109Cerebellar dysplasia (HP:0007033)2.01341039
110Hyperphosphatemia (HP:0002905)2.01325651
111Truncal obesity (HP:0001956)2.00799110
112Abnormality of chloride homeostasis (HP:0011422)1.99809087
113Facial shape deformation (HP:0011334)1.99433853
114Potter facies (HP:0002009)1.99433853
115Skin nodule (HP:0200036)1.98722053
116Abnormality of the labia majora (HP:0012881)1.98557918
117Confusion (HP:0001289)1.98344698
118Exocrine pancreatic insufficiency (HP:0001738)1.97425304
119Metaphyseal irregularity (HP:0003025)1.95612607
120Hypokalemic alkalosis (HP:0001949)1.94927835
121Abnormality of the parietal bone (HP:0002696)1.94633101
122Abnormality of aromatic amino acid family metabolism (HP:0004338)1.93857109
123Self-mutilation (HP:0000742)1.92912000
124Progressive neurologic deterioration (HP:0002344)1.92535199
125Hyperphosphaturia (HP:0003109)1.90004611
126Abnormality of alanine metabolism (HP:0010916)1.89371467
127Hyperalaninemia (HP:0003348)1.89371467
128Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.89371467
129Protuberant abdomen (HP:0001538)1.88773886
130Keratoconus (HP:0000563)1.88451413
131Increased corneal curvature (HP:0100692)1.88451413
132Hypoventilation (HP:0002791)1.88232042
133Bicornuate uterus (HP:0000813)1.87978314
134Dysautonomia (HP:0002459)1.86618417
135Elevated alkaline phosphatase (HP:0003155)1.84851247
136Papilledema (HP:0001085)1.84612027
137Submucous cleft hard palate (HP:0000176)1.84285229
138Sclerocornea (HP:0000647)1.83921368
139Stereotypic behavior (HP:0000733)1.83665339
140Hypotension (HP:0002615)1.83492059
141Depressed nasal tip (HP:0000437)1.83329257
142Congenital glaucoma (HP:0001087)1.83118321
143Underdeveloped nasal alae (HP:0000430)1.82448211
144Broad-based gait (HP:0002136)1.82362464
145Epileptic encephalopathy (HP:0200134)1.81491842
146Abnormality of the aortic arch (HP:0012303)1.80781202
147Tubulointerstitial abnormality (HP:0001969)1.80487940
148Hypocalcemia (HP:0002901)1.80157731
149Gout (HP:0001997)1.78739471
150Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.78575541
151Postural instability (HP:0002172)1.78028639
152Aplasia/Hypoplasia of the macula (HP:0008059)1.77870616
153Trigonocephaly (HP:0000243)1.76854244
154Villous atrophy (HP:0011473)1.75726175
155Abnormality of small intestinal villus morphology (HP:0011472)1.75726175
156Abnormal ciliary motility (HP:0012262)1.75567292
157Thin bony cortex (HP:0002753)1.74782594
158Abnormal urine phosphate concentration (HP:0012599)1.74420052
159Hypomagnesemia (HP:0002917)1.74043253
160Pancreatic fibrosis (HP:0100732)1.72766082
161Pancreatic cysts (HP:0001737)1.72592414
162Fair hair (HP:0002286)1.72203897
163Abnormal protein glycosylation (HP:0012346)1.70883112
164Abnormal glycosylation (HP:0012345)1.70883112
165Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.70883112
166Abnormal protein N-linked glycosylation (HP:0012347)1.70883112
167Abnormality of alkaline phosphatase activity (HP:0004379)1.69815865
168Impulsivity (HP:0100710)1.69688962
169Aplasia/hypoplasia of the uterus (HP:0008684)1.69062906
170Esophageal atresia (HP:0002032)1.68975422
171Widely patent fontanelles and sutures (HP:0004492)1.68925537
172Hyperaldosteronism (HP:0000859)1.67649310
173Shawl scrotum (HP:0000049)1.67610171
174Postural tremor (HP:0002174)1.67337873
175Hemiparesis (HP:0001269)1.66970991
176Shallow orbits (HP:0000586)1.66550004
177Aplasia/Hypoplasia affecting the retina (HP:0008061)1.65582230
178Abnormality of dental color (HP:0011073)1.64616656
179Tubular atrophy (HP:0000092)1.63947634
180Tetany (HP:0001281)1.63761858
181Hemiplegia (HP:0002301)1.63752986
182Type I transferrin isoform profile (HP:0003642)1.63612533
183Cutaneous syndactyly (HP:0012725)1.63143769
184Flat occiput (HP:0005469)1.63107164
185Anteriorly placed anus (HP:0001545)1.61639236
186Hepatoblastoma (HP:0002884)1.61209689
187Focal seizures (HP:0007359)1.61012060
188Intellectual disability, moderate (HP:0002342)1.60681606
189Aplasia/Hypoplasia of the earlobes (HP:0009906)1.60661785
190Congenital sensorineural hearing impairment (HP:0008527)1.60025480
191Type II diabetes mellitus (HP:0005978)1.59809878
192Facial hemangioma (HP:0000329)1.59778367
193Restlessness (HP:0000711)1.59605172

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PASK5.93246600
2MAPK155.04373146
3PLK44.20611401
4LATS14.03547245
5TAOK33.96685835
6HIPK23.53792573
7CAMKK12.82875296
8PRKD32.77470190
9PRKD22.76014496
10PNCK2.73217229
11MAP3K22.65709078
12CAMK1D2.56135263
13FRK2.49080188
14CAMK1G2.41074007
15IRAK12.32576457
16DDR22.25587576
17DYRK1B2.18739813
18IRAK32.15364071
19MUSK2.13755663
20NTRK32.10044749
21WNK41.99097131
22NTRK11.96832066
23ICK1.95660017
24FLT31.94960117
25EPHA31.89697742
26IRAK21.82864853
27GRK11.81381365
28CDC42BPA1.78266196
29MAP3K11.74039211
30MARK21.63289638
31TYRO31.63248008
32IRAK41.57435839
33ERN11.54487570
34PTK2B1.52371525
35TNK21.42528153
36WNK31.41401329
37UHMK11.40897434
38NEK21.40580505
39CDK121.37951289
40PRKCH1.34483512
41SIK21.32090476
42PDGFRA1.26243130
43DAPK21.25150885
44ADRBK21.23482687
45MAP4K21.21297708
46STK381.19597509
47PTK21.19553455
48CAMKK21.15965264
49CASK1.13514172
50MAP2K61.10009512
51RPS6KA61.09909293
52NME11.06485787
53MATK1.03415443
54AKT31.01128758
55NTRK20.99760009
56MET0.98373010
57PKN10.98032540
58PRKCE0.93429264
59MAP2K20.92738649
60ERBB20.92413553
61TNIK0.89927985
62FER0.89726575
63EIF2AK30.89521109
64* INSRR0.88323289
65FGFR20.86987232
66RPS6KA20.85578158
67WNK10.84440602
68TLK10.84273712
69NUAK10.84068129
70PAK30.83799387
71PRKCI0.83227169
72PRKAA10.82965155
73PRKAA20.81885209
74MTOR0.81746325
75NLK0.80838495
76STK160.80640795
77CHUK0.78693170
78BMX0.76788614
79KIT0.75526870
80PTK60.73269057
81ACVR1B0.73197353
82PRKD10.72927614
83SCYL20.72118588
84CAMK2D0.71950068
85DYRK30.70452800
86PLK20.70416147
87MAPK130.69947727
88CHEK20.64483583
89NEK60.59424570
90PIK3CG0.59388827
91CAMK2B0.59158328
92BRD40.58694838
93BLK0.58530339
94SIK10.58119165
95MAP3K70.58072904
96RET0.57085102
97BMPR20.56121768
98RPS6KA50.54632223
99EPHB10.54512101
100RPS6KC10.54132760
101RPS6KL10.54132760
102STK30.52964407
103OXSR10.52557664
104MAP2K10.51983106
105MAPK10.51329947
106MAP3K40.50775283
107GRK50.50639803
108JAK20.48813987
109AKT10.48718247
110BRSK20.48679092
111PDGFRB0.48208440
112ITK0.47912691
113PRKACA0.47065198
114KSR20.47048043
115JAK10.46955716
116PKN20.46342448
117DYRK1A0.45972848
118BCR0.44773259
119SIK30.44056827
120PDK10.43976495
121GSK3B0.43068151
122CAMK40.42986732
123TGFBR10.41735807
124CDK50.41615431
125PRKACG0.40634868
126CDK40.40394561
127PDPK10.40174242
128SGK4940.39905357
129SGK2230.39905357
130PRKCZ0.39241098
131CSNK1A10.39155656
132BMPR1B0.38918853
133TEC0.38530382
134CDK20.38457640
135MST1R0.38221166
136IGF1R0.37867697
137MAPK80.37732354
138MARK10.37368542
139STK38L0.37164539
140SGK20.37126838
141CDK10.36983094
142PRKDC0.36162493
143TRIB30.35934568
144CAMK10.34889102
145GSK3A0.34132156
146LIMK10.33793600
147JAK30.32542128
148DYRK20.32019007
149SGK10.28914247
150MARK30.28820016
151MAPK140.28280223
152PRKG10.28033527
153PRKCA0.27448575
154GRK70.27321549
155PRKCG0.27208088
156BTK0.27198202
157ADRBK10.26008918
158BRAF0.25571815
159CAMK2A0.23881206
160RPS6KB10.22904343

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049509.43185453
2Protein export_Homo sapiens_hsa030604.83575080
3Taurine and hypotaurine metabolism_Homo sapiens_hsa004304.40409716
4Insulin secretion_Homo sapiens_hsa049113.43281864
5Sulfur metabolism_Homo sapiens_hsa009202.79669299
6Type II diabetes mellitus_Homo sapiens_hsa049302.72789130
7Protein processing in endoplasmic reticulum_Homo sapiens_hsa041412.67970439
8Type I diabetes mellitus_Homo sapiens_hsa049402.29175081
9Carbohydrate digestion and absorption_Homo sapiens_hsa049732.02231397
10Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.87031133
11Fatty acid biosynthesis_Homo sapiens_hsa000611.83959425
12Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.79942350
13Vibrio cholerae infection_Homo sapiens_hsa051101.72148109
14Cocaine addiction_Homo sapiens_hsa050301.71207849
15Taste transduction_Homo sapiens_hsa047421.51958781
16Selenocompound metabolism_Homo sapiens_hsa004501.47437123
17Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.45313568
18Pancreatic secretion_Homo sapiens_hsa049721.34080183
19Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.34031215
20Phototransduction_Homo sapiens_hsa047441.31374475
21N-Glycan biosynthesis_Homo sapiens_hsa005101.30441803
22Amphetamine addiction_Homo sapiens_hsa050311.30345135
23Glycosaminoglycan degradation_Homo sapiens_hsa005311.26654936
24Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.25005302
25Lysosome_Homo sapiens_hsa041421.23363922
26Circadian rhythm_Homo sapiens_hsa047101.15459825
27Other glycan degradation_Homo sapiens_hsa005111.14501009
28Notch signaling pathway_Homo sapiens_hsa043301.13093394
29Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.12554502
30Glycerophospholipid metabolism_Homo sapiens_hsa005641.11105662
31Serotonergic synapse_Homo sapiens_hsa047261.05954555
32Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.03883641
33Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.00808073
34Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.97856543
35Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.96834679
36Circadian entrainment_Homo sapiens_hsa047130.96480580
37Regulation of autophagy_Homo sapiens_hsa041400.93396342
38Collecting duct acid secretion_Homo sapiens_hsa049660.93393285
39Bile secretion_Homo sapiens_hsa049760.92588024
40Phospholipase D signaling pathway_Homo sapiens_hsa040720.91822425
41Fanconi anemia pathway_Homo sapiens_hsa034600.91529055
42Glucagon signaling pathway_Homo sapiens_hsa049220.91497335
43Insulin resistance_Homo sapiens_hsa049310.91030475
44ABC transporters_Homo sapiens_hsa020100.90685449
45Cholinergic synapse_Homo sapiens_hsa047250.89712457
46Dopaminergic synapse_Homo sapiens_hsa047280.89375609
47Sphingolipid metabolism_Homo sapiens_hsa006000.89161630
48Aldosterone synthesis and secretion_Homo sapiens_hsa049250.87975371
49Long-term potentiation_Homo sapiens_hsa047200.87949339
50GABAergic synapse_Homo sapiens_hsa047270.87050388
51Hedgehog signaling pathway_Homo sapiens_hsa043400.85174178
52Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.81847127
53Prolactin signaling pathway_Homo sapiens_hsa049170.81136617
54Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.80498126
55Tryptophan metabolism_Homo sapiens_hsa003800.79843197
56Synaptic vesicle cycle_Homo sapiens_hsa047210.79457526
57SNARE interactions in vesicular transport_Homo sapiens_hsa041300.78703540
58Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.78273923
59Thyroid hormone synthesis_Homo sapiens_hsa049180.77613403
60Melanoma_Homo sapiens_hsa052180.77560142
61MAPK signaling pathway_Homo sapiens_hsa040100.74544791
62Linoleic acid metabolism_Homo sapiens_hsa005910.74405167
63Morphine addiction_Homo sapiens_hsa050320.73720313
64Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.71451214
65Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.71430966
66Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.71152031
67Vascular smooth muscle contraction_Homo sapiens_hsa042700.71043635
68Adipocytokine signaling pathway_Homo sapiens_hsa049200.70460821
69cGMP-PKG signaling pathway_Homo sapiens_hsa040220.69288570
70Glutamatergic synapse_Homo sapiens_hsa047240.68891888
71Basal cell carcinoma_Homo sapiens_hsa052170.68723127
72Glioma_Homo sapiens_hsa052140.67739875
73Folate biosynthesis_Homo sapiens_hsa007900.66859952
74VEGF signaling pathway_Homo sapiens_hsa043700.66520042
75Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.65195223
76Butanoate metabolism_Homo sapiens_hsa006500.64328696
77Renin secretion_Homo sapiens_hsa049240.63618495
78Homologous recombination_Homo sapiens_hsa034400.62362055
79Sulfur relay system_Homo sapiens_hsa041220.61368691
80Thyroid hormone signaling pathway_Homo sapiens_hsa049190.60736449
81alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.60698360
82Steroid hormone biosynthesis_Homo sapiens_hsa001400.59933529
83Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.58068027
84Axon guidance_Homo sapiens_hsa043600.57845569
85Prion diseases_Homo sapiens_hsa050200.56689563
86MicroRNAs in cancer_Homo sapiens_hsa052060.56236632
87Choline metabolism in cancer_Homo sapiens_hsa052310.55624761
88Chemical carcinogenesis_Homo sapiens_hsa052040.55468414
89Phenylalanine metabolism_Homo sapiens_hsa003600.55192487
90Estrogen signaling pathway_Homo sapiens_hsa049150.55032596
91Phosphatidylinositol signaling system_Homo sapiens_hsa040700.54395515
92Longevity regulating pathway - mammal_Homo sapiens_hsa042110.54337751
93ECM-receptor interaction_Homo sapiens_hsa045120.54061725
94Alcoholism_Homo sapiens_hsa050340.54060663
95cAMP signaling pathway_Homo sapiens_hsa040240.53939579
96Bladder cancer_Homo sapiens_hsa052190.53657612
97RNA polymerase_Homo sapiens_hsa030200.51914546
98Lysine degradation_Homo sapiens_hsa003100.50963076
99Nitrogen metabolism_Homo sapiens_hsa009100.50581109
100Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.49375072
101Retinol metabolism_Homo sapiens_hsa008300.49250410
102Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.49228948
103ErbB signaling pathway_Homo sapiens_hsa040120.48048574
104Starch and sucrose metabolism_Homo sapiens_hsa005000.46410712
105Histidine metabolism_Homo sapiens_hsa003400.44479729
106Arachidonic acid metabolism_Homo sapiens_hsa005900.43617164
107Galactose metabolism_Homo sapiens_hsa000520.43611320
108Insulin signaling pathway_Homo sapiens_hsa049100.43000194
109Dorso-ventral axis formation_Homo sapiens_hsa043200.42922357
110Ether lipid metabolism_Homo sapiens_hsa005650.42733541
111mTOR signaling pathway_Homo sapiens_hsa041500.41026875
112Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.40950967
113Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.40667976
114Protein digestion and absorption_Homo sapiens_hsa049740.40185398
115Glycerolipid metabolism_Homo sapiens_hsa005610.39833130
116Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.38678386
117Ovarian steroidogenesis_Homo sapiens_hsa049130.34453852
118Inositol phosphate metabolism_Homo sapiens_hsa005620.34420182
119TGF-beta signaling pathway_Homo sapiens_hsa043500.33891571
120Fatty acid elongation_Homo sapiens_hsa000620.33044723
121Tyrosine metabolism_Homo sapiens_hsa003500.32944667
122Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.32600329
123Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.31154163
124Long-term depression_Homo sapiens_hsa047300.27017901
125AMPK signaling pathway_Homo sapiens_hsa041520.26046744
126Phagosome_Homo sapiens_hsa041450.25921290
127Mineral absorption_Homo sapiens_hsa049780.25297162
128Salivary secretion_Homo sapiens_hsa049700.24517976
129Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.23288005
130Melanogenesis_Homo sapiens_hsa049160.23107474
131Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.22610157
132Fat digestion and absorption_Homo sapiens_hsa049750.22605181
133Calcium signaling pathway_Homo sapiens_hsa040200.22577779
134Oxytocin signaling pathway_Homo sapiens_hsa049210.22099937
135Gap junction_Homo sapiens_hsa045400.21337351
136Gastric acid secretion_Homo sapiens_hsa049710.20309681
137Rheumatoid arthritis_Homo sapiens_hsa053230.19861360
138GnRH signaling pathway_Homo sapiens_hsa049120.16279039
139Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.16177653
140Olfactory transduction_Homo sapiens_hsa047400.15316891
141Ras signaling pathway_Homo sapiens_hsa040140.15245135
142Nicotine addiction_Homo sapiens_hsa050330.14188829
143Dilated cardiomyopathy_Homo sapiens_hsa054140.12357562

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