INTS1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: INTS1 is a subunit of the Integrator complex, which associates with the C-terminal domain of RNA polymerase II large subunit (POLR2A; MIM 180660) and mediates 3-prime end processing of small nuclear RNAs U1 (RNU1; MIM 180680) and U2 (RNU2; MIM 180690) (Baillat et al., 2005 [PubMed 16239144]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1pre-miRNA processing (GO:0031054)4.91339109
2regulation of translational fidelity (GO:0006450)4.57953226
3heterochromatin organization (GO:0070828)4.44568587
4nuclear pore complex assembly (GO:0051292)4.41412229
5activation of Rac GTPase activity (GO:0032863)4.26453354
6nuclear pore organization (GO:0006999)4.20032641
7negative regulation of histone methylation (GO:0031061)4.17671115
8DNA unwinding involved in DNA replication (GO:0006268)4.15117803
9peptidyl-lysine dimethylation (GO:0018027)4.14847921
10COPI coating of Golgi vesicle (GO:0048205)4.14436332
11Golgi transport vesicle coating (GO:0048200)4.14436332
12regulation of translational termination (GO:0006449)3.95451278
13semaphorin-plexin signaling pathway (GO:0071526)3.94395147
14positive regulation of histone deacetylation (GO:0031065)3.92059675
15mannose metabolic process (GO:0006013)3.83917621
16planar cell polarity pathway involved in neural tube closure (GO:0090179)3.81159834
17proline biosynthetic process (GO:0006561)3.75717820
18regulation of glucose import in response to insulin stimulus (GO:2001273)3.73385925
19regulation of histone H3-K9 methylation (GO:0051570)3.72471822
20regulation of NFAT protein import into nucleus (GO:0051532)3.71024957
21cell-substrate junction assembly (GO:0007044)3.69196720
22protein localization to kinetochore (GO:0034501)3.60664554
23chromatin assembly (GO:0031497)3.56662084
24negative regulation of cell size (GO:0045792)3.54697860
25intracellular estrogen receptor signaling pathway (GO:0030520)3.52746746
26chromatin silencing (GO:0006342)3.50594325
27protein retention in ER lumen (GO:0006621)3.47606196
28retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.46731556
29regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.46089660
30regulation of mammary gland epithelial cell proliferation (GO:0033599)3.44295096
31desmosome organization (GO:0002934)3.39426832
32protein localization to endosome (GO:0036010)3.39190513
33negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.38703671
34dosage compensation (GO:0007549)3.38133618
35gene silencing (GO:0016458)3.33932674
36regulation of early endosome to late endosome transport (GO:2000641)3.33814699
37spliceosomal tri-snRNP complex assembly (GO:0000244)3.33508525
38mitotic nuclear envelope disassembly (GO:0007077)3.32489204
39positive regulation of RNA splicing (GO:0033120)3.31597718
40cytoskeletal anchoring at plasma membrane (GO:0007016)3.30970611
41histone H4-K12 acetylation (GO:0043983)3.30875253
42epithelial cell-cell adhesion (GO:0090136)3.30447212
43maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.30127754
44glucocorticoid receptor signaling pathway (GO:0042921)3.29871122
45hemidesmosome assembly (GO:0031581)3.26225041
46mitotic G1 DNA damage checkpoint (GO:0031571)3.24944657
47basement membrane organization (GO:0071711)3.22792673
48nucleosome disassembly (GO:0006337)3.20437165
49protein-DNA complex disassembly (GO:0032986)3.20437165
50membrane disassembly (GO:0030397)3.19271187
51nuclear envelope disassembly (GO:0051081)3.19271187
52peptidyl-arginine omega-N-methylation (GO:0035247)3.18289958
53regulation of RNA export from nucleus (GO:0046831)3.17067762
54NLS-bearing protein import into nucleus (GO:0006607)3.16241814
55epithelial cell differentiation involved in prostate gland development (GO:0060742)3.15585207
56DNA duplex unwinding (GO:0032508)3.14339542
57RNA stabilization (GO:0043489)3.13730031
58mRNA stabilization (GO:0048255)3.13730031
59regulation of histone H3-K27 methylation (GO:0061085)3.13533674
60negative regulation of gene expression, epigenetic (GO:0045814)3.11679897
61mitotic chromosome condensation (GO:0007076)3.11387734
62insulin-like growth factor receptor signaling pathway (GO:0048009)3.10150809
63pore complex assembly (GO:0046931)3.09713010
64DNA geometric change (GO:0032392)3.09207126
65atrioventricular valve morphogenesis (GO:0003181)3.08912740
66histone H4-K16 acetylation (GO:0043984)3.08186683
67cytoplasmic mRNA processing body assembly (GO:0033962)3.06468808
68gene silencing by RNA (GO:0031047)3.05029920
69negative regulation of histone modification (GO:0031057)3.04671554
70positive regulation of gene expression, epigenetic (GO:0045815)3.02176096
71histone H4-K8 acetylation (GO:0043982)3.02150628
72histone H4-K5 acetylation (GO:0043981)3.02150628
73sister chromatid segregation (GO:0000819)3.01984594
74mitotic sister chromatid cohesion (GO:0007064)2.99886744
75negative regulation of fatty acid transport (GO:2000192)2.96569236
76negative regulation of RNA splicing (GO:0033119)2.94894222
77regulation of chromatin binding (GO:0035561)2.91867413
78negative regulation of mRNA metabolic process (GO:1903312)2.91676741
79peptidyl-arginine N-methylation (GO:0035246)2.90223224
80peptidyl-arginine methylation (GO:0018216)2.90223224
81protein localization to chromosome, centromeric region (GO:0071459)2.90142345
82embryonic process involved in female pregnancy (GO:0060136)2.88496425
83negative regulation of erythrocyte differentiation (GO:0045647)2.87369988
84regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.87354032
85positive regulation of Cdc42 GTPase activity (GO:0043089)2.85135309
86adherens junction assembly (GO:0034333)2.84647745
87positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.83949387
88mitotic sister chromatid segregation (GO:0000070)2.83823369
89apoptotic process involved in development (GO:1902742)2.81329148
90natural killer cell differentiation (GO:0001779)2.80013618
91negative regulation of mRNA processing (GO:0050686)2.78666815
92G1 DNA damage checkpoint (GO:0044783)2.78196735
93regulation of gene silencing by RNA (GO:0060966)2.78092631
94regulation of posttranscriptional gene silencing (GO:0060147)2.78092631
95regulation of gene silencing by miRNA (GO:0060964)2.78092631
96establishment of apical/basal cell polarity (GO:0035089)2.77568013
97positive regulation of protein deacetylation (GO:0090312)2.76761809
98maternal placenta development (GO:0001893)2.75174736
99positive regulation of blood vessel endothelial cell migration (GO:0043536)2.75053164
100mitotic G1/S transition checkpoint (GO:0044819)2.74731618
101folic acid-containing compound biosynthetic process (GO:0009396)2.73811661
102nuclear envelope organization (GO:0006998)2.73692944
103positive regulation of receptor recycling (GO:0001921)2.73522919
104regulation of gamma-delta T cell differentiation (GO:0045586)2.72917707
105cell-cell junction maintenance (GO:0045217)2.72240347
106negative regulation of chromatin modification (GO:1903309)2.72121736
107positive regulation of chromosome segregation (GO:0051984)2.72012905
108endothelial cell chemotaxis (GO:0035767)2.71295686
109regulation of nucleobase-containing compound transport (GO:0032239)2.70985510
110histone H3-K36 demethylation (GO:0070544)2.70593714
111response to laminar fluid shear stress (GO:0034616)2.70223776
112glucose catabolic process (GO:0006007)2.69169087
113negative regulation of viral release from host cell (GO:1902187)2.67981964
114pentose-phosphate shunt (GO:0006098)2.67246392
115regulation of ARF GTPase activity (GO:0032312)2.66763704
116histone H4 acetylation (GO:0043967)2.66109676
117negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)2.65483085
118histone H2A monoubiquitination (GO:0035518)2.64875018
119branching involved in mammary gland duct morphogenesis (GO:0060444)2.64656965
120regulation of extracellular matrix disassembly (GO:0010715)2.64074544
121stress granule assembly (GO:0034063)2.62992446
122DNA replication-dependent nucleosome assembly (GO:0006335)2.62566503
123DNA replication-dependent nucleosome organization (GO:0034723)2.62566503
124IMP biosynthetic process (GO:0006188)2.61599978
125vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.61361103
126alternative mRNA splicing, via spliceosome (GO:0000380)2.61257868
127neural tube development (GO:0021915)2.61219730
128corticosteroid receptor signaling pathway (GO:0031958)2.61076956
129positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.61059250
130regulation of sister chromatid cohesion (GO:0007063)2.60567515
131regulation of hippo signaling (GO:0035330)2.59220320
132activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.58823492
133barbed-end actin filament capping (GO:0051016)2.58693135
134regulation of fatty acid beta-oxidation (GO:0031998)2.58546967
135histone H3-K4 methylation (GO:0051568)2.58412154
136regulation of cholesterol biosynthetic process (GO:0045540)2.57940069
137trophectodermal cell differentiation (GO:0001829)2.57845554
138negative regulation of myotube differentiation (GO:0010832)2.57780503
139cell-substrate adherens junction assembly (GO:0007045)2.57716409
140focal adhesion assembly (GO:0048041)2.57716409
141glucose 6-phosphate metabolic process (GO:0051156)2.57398025
142regulation of cholesterol homeostasis (GO:2000188)2.55882082
143proline metabolic process (GO:0006560)2.55792482
1443-UTR-mediated mRNA stabilization (GO:0070935)2.55748754
145positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.55566752
146activation of MAPKKK activity (GO:0000185)2.54961155
147stress fiber assembly (GO:0043149)2.54231086
148embryonic eye morphogenesis (GO:0048048)2.54119731
149regulation of histone H3-K4 methylation (GO:0051569)2.53914018
150cellular response to epidermal growth factor stimulus (GO:0071364)2.53710814
151activation of JUN kinase activity (GO:0007257)2.53335690
152apoptotic process involved in morphogenesis (GO:0060561)2.50693485
153positive regulation of SMAD protein import into nucleus (GO:0060391)2.49725809
154translesion synthesis (GO:0019985)2.49227360
155positive regulation of nuclease activity (GO:0032075)2.48431745
156histone lysine demethylation (GO:0070076)2.47239940
157dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.45726006
158peptidyl-tyrosine autophosphorylation (GO:0038083)2.44358429
159histone lysine methylation (GO:0034968)2.44344527
160convergent extension (GO:0060026)2.43936325
161regulation of translational elongation (GO:0006448)2.43077556
162protein targeting to plasma membrane (GO:0072661)2.42779694
163regulation of ARF protein signal transduction (GO:0032012)2.41599724
164DNA conformation change (GO:0071103)2.40865686
165developmental programmed cell death (GO:0010623)2.36316575
166positive regulation of protein dephosphorylation (GO:0035307)2.35030759
167regulation of endothelial cell chemotaxis (GO:2001026)2.33988692
168histone H4 deacetylation (GO:0070933)2.31083965
169cell volume homeostasis (GO:0006884)2.30982351
170Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.30912430
171cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.30878592
172osteoblast development (GO:0002076)2.30146489
173thymic T cell selection (GO:0045061)2.29736886
174G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.28233587

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.58601778
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.54264880
3MYC_22102868_ChIP-Seq_BL_Human4.18180294
4TP63_17297297_ChIP-ChIP_HaCaT_Human3.68290080
5NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.19484780
6EGR1_19374776_ChIP-ChIP_THP-1_Human3.14211548
7VDR_21846776_ChIP-Seq_THP-1_Human2.85522506
8KDM2B_26808549_Chip-Seq_DND41_Human2.69310973
9STAT6_21828071_ChIP-Seq_BEAS2B_Human2.63930224
10THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.62255246
11* TCF7_22412390_ChIP-Seq_EML_Mouse2.55694406
12RARG_19884340_ChIP-ChIP_MEFs_Mouse2.42513926
13EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.42037153
14* KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.40875624
15* KDM2B_26808549_Chip-Seq_SUP-B15_Human2.39803534
16KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.38355757
17EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.19678495
18TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.13834766
19TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.04123848
20ZFP281_18757296_ChIP-ChIP_E14_Mouse1.99300674
21ELK3_25401928_ChIP-Seq_HUVEC_Human1.99199224
22NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.98729331
23CIITA_25753668_ChIP-Seq_RAJI_Human1.97478990
24E2F4_17652178_ChIP-ChIP_JURKAT_Human1.86463604
25ZFP281_27345836_Chip-Seq_ESCs_Mouse1.84643492
26ESR2_21235772_ChIP-Seq_MCF-7_Human1.84508733
27KDM2B_26808549_Chip-Seq_JURKAT_Human1.81193077
28LXR_22292898_ChIP-Seq_THP-1_Human1.76017433
29CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.75725503
30* UTX_26944678_Chip-Seq_JUKART_Human1.75680684
31ZNF263_19887448_ChIP-Seq_K562_Human1.73237468
32MYC_19079543_ChIP-ChIP_MESCs_Mouse1.66399084
33MAF_26560356_Chip-Seq_TH1_Human1.66372880
34PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.65643324
35ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.65421918
36* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.62100220
37KDM2B_26808549_Chip-Seq_K562_Human1.62081947
38DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.60121259
39ERG_21242973_ChIP-ChIP_JURKAT_Human1.58546522
40SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.54376612
41TET1_21451524_ChIP-Seq_MESCs_Mouse1.52055840
42P300_27058665_Chip-Seq_ZR-75-30cells_Human1.49734848
43* SMC4_20622854_ChIP-Seq_HELA_Human1.48838547
44E2F1_21310950_ChIP-Seq_MCF-7_Human1.46794498
45RACK7_27058665_Chip-Seq_MCF-7_Human1.46284093
46KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.44359260
47* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.44309494
48SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.44132758
49MYC_18555785_ChIP-Seq_MESCs_Mouse1.44112705
50* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.43888850
51WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.38215152
52CLOCK_20551151_ChIP-Seq_293T_Human1.37545982
53NCOR1_26117541_ChIP-Seq_K562_Human1.36745525
54EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.35320912
55KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.34383770
56VDR_24763502_ChIP-Seq_THP-1_Human1.34111669
57CREB1_26743006_Chip-Seq_LNCaP_Human1.32186175
58FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.31415790
59CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.30013035
60STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.29954275
61ATF3_27146783_Chip-Seq_COLON_Human1.28950291
62TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.28879281
63SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.27821881
64* P68_20966046_ChIP-Seq_HELA_Human1.25778889
65TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.24260561
66TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.22158749
67TP53_22127205_ChIP-Seq_IMR90_Human1.21968434
68KDM5A_27292631_Chip-Seq_BREAST_Human1.21629237
69SRY_22984422_ChIP-ChIP_TESTIS_Rat1.21555565
70MAF_26560356_Chip-Seq_TH2_Human1.21491325
71RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.20170911
72ESR1_15608294_ChIP-ChIP_MCF-7_Human1.20166830
73ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.20092023
74PKCTHETA_26484144_Chip-Seq_BREAST_Human1.20081734
75KLF4_18555785_ChIP-Seq_MESCs_Mouse1.19248761
76DNAJC2_21179169_ChIP-ChIP_NT2_Human1.18845316
77CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.18781155
78SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.18761081
79GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.17243824
80KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.17127586
81ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.15802112
82TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.15692798
83SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.14910463
84XRN2_22483619_ChIP-Seq_HELA_Human1.14821860
85STAT3_1855785_ChIP-Seq_MESCs_Mouse1.12232825
86NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.11055796
87FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.10426784
88POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.09741133
89SPI1_23127762_ChIP-Seq_K562_Human1.09143789
90KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.09091415
91TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.08570591
92CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.07522101
93MYB_26560356_Chip-Seq_TH1_Human1.06618599
94MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.06010617
95NANOG_21062744_ChIP-ChIP_HESCs_Human1.05788887
96CTCF_27219007_Chip-Seq_Bcells_Human1.05671935
97SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.05564407
98UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.05529831
99* ELF1_20517297_ChIP-Seq_JURKAT_Human1.05139079
100CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.05005225
101BRD4_27068464_Chip-Seq_AML-cells_Mouse1.03459352
102UBF1/2_26484160_Chip-Seq_HMECs_Human1.03275239
103GATA1_22383799_ChIP-Seq_G1ME_Mouse1.02633935
104ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.02441087
105BCOR_27268052_Chip-Seq_Bcells_Human1.02066982
106CHD1_26751641_Chip-Seq_LNCaP_Human1.01868494
107RARB_27405468_Chip-Seq_BRAIN_Mouse1.01364832
108POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.01243791
109MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.99771273
110* SCL_19346495_ChIP-Seq_HPC-7_Human0.99650187
111CTCF_27219007_Chip-Seq_ERYTHROID_Human0.99513392
112RUNX1_27514584_Chip-Seq_MCF-7_Human0.99495335
113TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.99407203
114VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.98906500
115GATA1_19941827_ChIP-Seq_MEL_Mouse0.98652598
116HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.98470139
117CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.97978769
118EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.97823522
119TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.97742574
120STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.97148890
121ESR1_21235772_ChIP-Seq_MCF-7_Human0.96957875
122HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.96452777
123SETDB1_19884255_ChIP-Seq_MESCs_Mouse0.96329365
124TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.95761922
125FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.95684279
126MYCN_18555785_ChIP-Seq_MESCs_Mouse0.95359330
127* RUNX1_22412390_ChIP-Seq_EML_Mouse0.95184677
128TP63_22573176_ChIP-Seq_HFKS_Human0.95074696
129PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.93418627
130* TET1_21490601_ChIP-Seq_MESCs_Mouse0.93061772
131SA1_27219007_Chip-Seq_ERYTHROID_Human0.92712135
132AR_21909140_ChIP-Seq_LNCAP_Human0.92280111
133ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.92213327
134MYB_26560356_Chip-Seq_TH2_Human0.91582362
135ZFX_18555785_ChIP-Seq_MESCs_Mouse0.91383102
136MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.90066065
137MYC_19030024_ChIP-ChIP_MESCs_Mouse0.89714618
138HIF1A_21447827_ChIP-Seq_MCF-7_Human0.89407765

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003705_abnormal_hypodermis_morpholog3.70672540
2MP0010352_gastrointestinal_tract_polyps3.31537183
3MP0005076_abnormal_cell_differentiation3.29821187
4MP0003111_abnormal_nucleus_morphology2.98853445
5MP0005451_abnormal_body_composition2.78939803
6MP0009278_abnormal_bone_marrow2.62120293
7MP0008438_abnormal_cutaneous_collagen2.50453436
8MP0010307_abnormal_tumor_latency2.45491060
9MP0005058_abnormal_lysosome_morphology2.39779704
10MP0010094_abnormal_chromosome_stability2.29015180
11MP0008877_abnormal_DNA_methylation2.24596069
12MP0005409_darkened_coat_color2.22461321
13MP0002396_abnormal_hematopoietic_system2.18899377
14MP0008961_abnormal_basal_metabolism2.18890923
15* MP0001730_embryonic_growth_arrest2.18278267
16MP0008260_abnormal_autophagy2.11922934
17MP0003453_abnormal_keratinocyte_physiol2.08564585
18MP0003077_abnormal_cell_cycle2.07724519
19MP0004808_abnormal_hematopoietic_stem2.07591149
20MP0003300_gastrointestinal_ulcer2.04066143
21MP0001849_ear_inflammation2.00849888
22MP0000678_abnormal_parathyroid_gland1.93188874
23MP0002796_impaired_skin_barrier1.92482988
24MP0002249_abnormal_larynx_morphology1.88909616
25MP0004957_abnormal_blastocyst_morpholog1.88051780
26MP0000350_abnormal_cell_proliferation1.80093158
27MP0003172_abnormal_lysosome_physiology1.80033178
28MP0004197_abnormal_fetal_growth/weight/1.78302921
29MP0002084_abnormal_developmental_patter1.72890715
30MP0004233_abnormal_muscle_weight1.66456244
31MP0000569_abnormal_digit_pigmentation1.65368309
32MP0005380_embryogenesis_phenotype1.64621102
33MP0001672_abnormal_embryogenesis/_devel1.64621102
34MP0005257_abnormal_intraocular_pressure1.64022619
35MP0003984_embryonic_growth_retardation1.63373850
36MP0003123_paternal_imprinting1.61078293
37MP0002060_abnormal_skin_morphology1.61003591
38MP0000733_abnormal_muscle_development1.60101722
39MP0002088_abnormal_embryonic_growth/wei1.59931762
40MP0005623_abnormal_meninges_morphology1.58435216
41MP0002086_abnormal_extraembryonic_tissu1.57454816
42MP0000566_synostosis1.56138936
43MP0003566_abnormal_cell_adhesion1.54786122
44MP0001697_abnormal_embryo_size1.54647201
45MP0000537_abnormal_urethra_morphology1.52720164
46MP0000703_abnormal_thymus_morphology1.52202748
47MP0002085_abnormal_embryonic_tissue1.51589542
48MP0004381_abnormal_hair_follicle1.51578465
49MP0004264_abnormal_extraembryonic_tissu1.51412354
50MP0005501_abnormal_skin_physiology1.50924084
51MP0005397_hematopoietic_system_phenotyp1.48575310
52MP0001545_abnormal_hematopoietic_system1.48575310
53MP0003303_peritoneal_inflammation1.47321144
54MP0003693_abnormal_embryo_hatching1.46208130
55MP0004272_abnormal_basement_membrane1.46146439
56* MP0002080_prenatal_lethality1.44035725
57MP0002877_abnormal_melanocyte_morpholog1.43940341
58MP0003115_abnormal_respiratory_system1.40209559
59MP0009840_abnormal_foam_cell1.35780018
60MP0008057_abnormal_DNA_replication1.35037470
61MP0008007_abnormal_cellular_replicative1.33595851
62MP0004947_skin_inflammation1.32858716
63MP0009672_abnormal_birth_weight1.32673984
64MP0006054_spinal_hemorrhage1.32284050
65MP0010234_abnormal_vibrissa_follicle1.31606558
66MP0004185_abnormal_adipocyte_glucose1.31464727
67MP0009780_abnormal_chondrocyte_physiolo1.30494359
68MP0004859_abnormal_synaptic_plasticity1.29060671
69MP0003283_abnormal_digestive_organ1.27387838
70MP0000003_abnormal_adipose_tissue1.26734842
71MP0005670_abnormal_white_adipose1.25993782
72MP0003121_genomic_imprinting1.23849511
73MP0008770_decreased_survivor_rate1.23764226
74MP0003191_abnormal_cellular_cholesterol1.23105259
75MP0000579_abnormal_nail_morphology1.21813652
76MP0010630_abnormal_cardiac_muscle1.20212864
77MP0003091_abnormal_cell_migration1.18608344
78MP0004084_abnormal_cardiac_muscle1.17670634
79MP0000428_abnormal_craniofacial_morphol1.17296182
80MP0000858_altered_metastatic_potential1.17130008
81MP0002925_abnormal_cardiovascular_devel1.16518853
82MP0003567_abnormal_fetal_cardiomyocyte1.13437570
83MP0001915_intracranial_hemorrhage1.12685481
84MP0003763_abnormal_thymus_physiology1.12569534
85MP0005375_adipose_tissue_phenotype1.09878549
86MP0009703_decreased_birth_body1.09078435
87MP0000467_abnormal_esophagus_morphology1.08640376
88MP0000759_abnormal_skeletal_muscle1.08034246
89MP0002398_abnormal_bone_marrow1.07729717
90MP0002089_abnormal_postnatal_growth/wei1.06418035
91MP0008995_early_reproductive_senescence1.06256130
92MP0002653_abnormal_ependyma_morphology1.06061141
93MP0004087_abnormal_muscle_fiber1.05651637
94MP0003787_abnormal_imprinting1.04908749
95MP0003279_aneurysm1.04295336
96MP0004858_abnormal_nervous_system1.03415165
97MP0000767_abnormal_smooth_muscle1.02845552
98MP0003329_amyloid_beta_deposits1.01356127
99MP0002098_abnormal_vibrissa_morphology1.00536273
100MP0005023_abnormal_wound_healing1.00443003
101MP0006138_congestive_heart_failure0.98167631
102MP0000266_abnormal_heart_morphology0.97772537
103MP0001958_emphysema0.96332208
104MP0005666_abnormal_adipose_tissue0.96094152
105MP0000313_abnormal_cell_death0.96031208
106MP0003045_fibrosis0.94852683
107MP0001216_abnormal_epidermal_layer0.94317690
108MP0002019_abnormal_tumor_incidence0.94026766
109MP0002722_abnormal_immune_system0.92382963
110MP0003119_abnormal_digestive_system0.92078871
111MP0001873_stomach_inflammation0.91668356
112MP0002254_reproductive_system_inflammat0.91224125
113MP0002269_muscular_atrophy0.90926157
114MP0009931_abnormal_skin_appearance0.89999996
115MP0001784_abnormal_fluid_regulation0.88054437
116MP0001348_abnormal_lacrimal_gland0.87359970
117MP0003436_decreased_susceptibility_to0.87081686
118MP0005621_abnormal_cell_physiology0.86360747
119MP0000747_muscle_weakness0.84602263
120MP0000751_myopathy0.84360226
121MP0009384_cardiac_valve_regurgitation0.83421638
122MP0003861_abnormal_nervous_system0.83103748
123MP0003878_abnormal_ear_physiology0.82640291
124MP0005377_hearing/vestibular/ear_phenot0.82640291
125MP0002166_altered_tumor_susceptibility0.82299621
126MP0002896_abnormal_bone_mineralization0.82296422
127MP0000534_abnormal_ureter_morphology0.80473324
128MP0005275_abnormal_skin_tensile0.80074512
129MP0003786_premature_aging0.79600408
130MP0002998_abnormal_bone_remodeling0.78554652
131MP0000377_abnormal_hair_follicle0.76498107
132MP0000681_abnormal_thyroid_gland0.76395433
133MP0000462_abnormal_digestive_system0.75911988
134MP0003935_abnormal_craniofacial_develop0.75850872
135MP0002009_preneoplasia0.75705693
136MP0004885_abnormal_endolymph0.75568191
137MP0010030_abnormal_orbit_morphology0.75274605
138MP0000762_abnormal_tongue_morphology0.74735974
139MP0000689_abnormal_spleen_morphology0.74090286
140MP0003942_abnormal_urinary_system0.73977696
141MP0003634_abnormal_glial_cell0.71475886
142MP0004510_myositis0.71399503
143MP0000490_abnormal_crypts_of0.71296879
144MP0004782_abnormal_surfactant_physiolog0.70421886
145MP0005384_cellular_phenotype0.70113302
146MP0002970_abnormal_white_adipose0.69815484
147MP0002092_abnormal_eye_morphology0.69523663
148MP0003890_abnormal_embryonic-extraembry0.69425963
149MP0003866_abnormal_defecation0.68255723
150MP0000477_abnormal_intestine_morphology0.67954358
151MP0005508_abnormal_skeleton_morphology0.67884605
152MP0010771_integument_phenotype0.67193891

Predicted human phenotypes

RankGene SetZ-score
1Hyperacusis (HP:0010780)5.09063760
2Broad face (HP:0000283)3.71336527
3Insomnia (HP:0100785)3.57061868
4Elfin facies (HP:0004428)3.50524881
5Ependymoma (HP:0002888)3.46781760
6Renovascular hypertension (HP:0100817)3.44250535
7Obstructive sleep apnea (HP:0002870)3.42624085
8Cerebral aneurysm (HP:0004944)3.34764186
9Renal duplication (HP:0000075)3.24184355
10Overriding aorta (HP:0002623)3.20884296
11Abnormality of the lower motor neuron (HP:0002366)3.20250123
12Bowel diverticulosis (HP:0005222)3.05927214
13Abnormality of the astrocytes (HP:0100707)3.00280843
14Astrocytoma (HP:0009592)3.00280843
15Premature rupture of membranes (HP:0001788)2.93377250
16Increased nuchal translucency (HP:0010880)2.84426360
17Abnormality of the fingertips (HP:0001211)2.82280304
18Distal upper limb amyotrophy (HP:0007149)2.80909301
19Upper limb amyotrophy (HP:0009129)2.80909301
20Pointed chin (HP:0000307)2.76819610
21Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.75810771
22Short 4th metacarpal (HP:0010044)2.75810771
23Hand muscle atrophy (HP:0009130)2.74829292
24Flat cornea (HP:0007720)2.68978551
25Shallow orbits (HP:0000586)2.67739559
26Macroorchidism (HP:0000053)2.62314146
27Bladder diverticulum (HP:0000015)2.59765539
28Heterotopia (HP:0002282)2.53828552
29Disproportionate tall stature (HP:0001519)2.48421732
30Distal lower limb muscle weakness (HP:0009053)2.46681117
31Stridor (HP:0010307)2.42627367
32Fragile skin (HP:0001030)2.42455644
33Dysmetric saccades (HP:0000641)2.41178698
34Thin bony cortex (HP:0002753)2.37585857
35Flat acetabular roof (HP:0003180)2.37359417
36Centrally nucleated skeletal muscle fibers (HP:0003687)2.35994082
37Cervical subluxation (HP:0003308)2.33849032
38Long palpebral fissure (HP:0000637)2.28140122
39Basal cell carcinoma (HP:0002671)2.28105128
40High pitched voice (HP:0001620)2.26072056
41Long eyelashes (HP:0000527)2.24776291
42J-shaped sella turcica (HP:0002680)2.23909605
43Mildly elevated creatine phosphokinase (HP:0008180)2.22437135
44Increased density of long bones (HP:0006392)2.21185054
45Medulloblastoma (HP:0002885)2.20184362
46Vertebral compression fractures (HP:0002953)2.16876631
47Prominent nose (HP:0000448)2.16175440
48Glioma (HP:0009733)2.14378791
49Pseudobulbar signs (HP:0002200)2.14338715
50Obsessive-compulsive behavior (HP:0000722)2.14271328
51Megalocornea (HP:0000485)2.13440603
52Vertebral arch anomaly (HP:0008438)2.13370049
53Advanced eruption of teeth (HP:0006288)2.12782163
54Increased variability in muscle fiber diameter (HP:0003557)2.11561532
55Abnormality of the diencephalon (HP:0010662)2.11046547
56Abnormality of oral frenula (HP:0000190)2.10467788
57Broad palm (HP:0001169)2.08888886
58Ankyloglossia (HP:0010296)2.08146303
59Abnormality of the distal phalanx of the thumb (HP:0009617)2.07927289
60Enlarged penis (HP:0000040)2.06764265
61Hemorrhage of the eye (HP:0011885)2.06566789
62Abnormality of the Achilles tendon (HP:0005109)2.05926040
63Biconcave vertebral bodies (HP:0004586)2.05878458
64Genu recurvatum (HP:0002816)2.05266017
65Spinal rigidity (HP:0003306)2.04548286
66Turricephaly (HP:0000262)2.04067955
67Abnormality of the 4th metacarpal (HP:0010012)2.03407522
68Urethral obstruction (HP:0000796)2.01666947
69Protrusio acetabuli (HP:0003179)2.00676388
70Neoplasm of the oral cavity (HP:0100649)1.99951453
71Trigonocephaly (HP:0000243)1.99929833
72Asymmetry of the thorax (HP:0001555)1.99351240
73Ulnar bowing (HP:0003031)1.99158829
74Selective tooth agenesis (HP:0001592)1.98959439
75Atrophic scars (HP:0001075)1.97385181
76Ankle contracture (HP:0006466)1.97340941
77Neoplasm of striated muscle (HP:0009728)1.96481652
78Annular pancreas (HP:0001734)1.95471517
79Myopathic facies (HP:0002058)1.94197535
80Premature skin wrinkling (HP:0100678)1.93264986
81Abnormality of the thoracic spine (HP:0100711)1.92015435
82Abnormality of skeletal muscle fiber size (HP:0012084)1.90742124
83Bronchomalacia (HP:0002780)1.89951556
84Fibroma (HP:0010614)1.87987554
85Skin tags (HP:0010609)1.87207391
86Deviation of the thumb (HP:0009603)1.87114850
87Abnormality of the distal phalanges of the toes (HP:0010182)1.86811389
88Patellar dislocation (HP:0002999)1.86195470
89Blue sclerae (HP:0000592)1.83727679
90Proximal placement of thumb (HP:0009623)1.83495127
91Fibrous tissue neoplasm (HP:0012316)1.82923073
92Trismus (HP:0000211)1.82271895
93Difficulty climbing stairs (HP:0003551)1.81760174
94Short nail (HP:0001799)1.81167901
95Difficulty running (HP:0009046)1.80488548
96Missing ribs (HP:0000921)1.79832299
97Subacute progressive viral hepatitis (HP:0006572)1.79059402
98Neoplasm of the heart (HP:0100544)1.78812124
99Dislocated radial head (HP:0003083)1.78792324
100Narrow palate (HP:0000189)1.78566763
101Easy fatigability (HP:0003388)1.78462842
102Rectal prolapse (HP:0002035)1.78140391
103Increased connective tissue (HP:0009025)1.77759889
104Mitral valve prolapse (HP:0001634)1.77525092
105Aneurysm (HP:0002617)1.77455967
106Sacral dimple (HP:0000960)1.77248093
107Malignant gastrointestinal tract tumors (HP:0006749)1.77084353
108Gastrointestinal carcinoma (HP:0002672)1.77084353
109Metaphyseal cupping (HP:0003021)1.76769911
110Deviation of the hallux (HP:0010051)1.75765235
111Hallux valgus (HP:0001822)1.75216543
112Sandal gap (HP:0001852)1.75087514
113Resting tremor (HP:0002322)1.75081300
114Wormian bones (HP:0002645)1.75012766
115Dilatation of the ascending aorta (HP:0005111)1.74599670
116Precocious puberty (HP:0000826)1.72910202
117Natal tooth (HP:0000695)1.72768544
118Syringomyelia (HP:0003396)1.72624525
119Spinal cord lesions (HP:0100561)1.72624525
120Absent frontal sinuses (HP:0002688)1.72524764
121Achilles tendon contracture (HP:0001771)1.71860390
122Lymphangioma (HP:0100764)1.71338040
123Attention deficit hyperactivity disorder (HP:0007018)1.70084449
124Cellulitis (HP:0100658)1.69132017
125Papilloma (HP:0012740)1.69077076
126Verrucae (HP:0200043)1.69077076
127Germ cell neoplasia (HP:0100728)1.68387031
128Thin ribs (HP:0000883)1.67911582
129Abnormality of the radial head (HP:0003995)1.66814600
130Reticulocytosis (HP:0001923)1.66654725
131Cafe-au-lait spot (HP:0000957)1.65896193
132Cerebral inclusion bodies (HP:0100314)1.65748397
133Broad thumb (HP:0011304)1.65596206
134Broad distal phalanx of finger (HP:0009836)1.64378915
135Lower limb amyotrophy (HP:0007210)1.63729394
136Cutaneous melanoma (HP:0012056)1.62481953
137Sparse lateral eyebrow (HP:0005338)1.62356730
138Bundle branch block (HP:0011710)1.62266376
139Abnormality of the calcaneus (HP:0008364)1.61333737
140Hypopigmentation of the fundus (HP:0007894)1.59709416
141Adenoma sebaceum (HP:0009720)1.59682323
142Angiofibromas (HP:0010615)1.59682323
143Rhabdomyosarcoma (HP:0002859)1.59494875
144Generalized amyotrophy (HP:0003700)1.58931248
145Distal lower limb amyotrophy (HP:0008944)1.58626728
146Mitral regurgitation (HP:0001653)1.58236120
147Arnold-Chiari malformation (HP:0002308)1.57887263
148Osteolytic defects of the hand bones (HP:0009699)1.57655629
149Osteolytic defects of the phalanges of the hand (HP:0009771)1.57655629
150Spina bifida occulta (HP:0003298)1.56446519
151Acute lymphatic leukemia (HP:0006721)1.56328667
152Supernumerary ribs (HP:0005815)1.55494335
153Deformed sella turcica (HP:0002681)1.55298474
154Colon cancer (HP:0003003)1.54963395
155Elbow flexion contracture (HP:0002987)1.54956103
156Colitis (HP:0002583)1.54889819
157Persistence of primary teeth (HP:0006335)1.54569385
158Joint laxity (HP:0001388)1.54210996
159Exercise-induced myalgia (HP:0003738)1.54004850
160Hyperparathyroidism (HP:0000843)1.53412282
161Bowel incontinence (HP:0002607)1.52873452
162Bulbar palsy (HP:0001283)1.51622908
163Thoracic kyphosis (HP:0002942)1.49999371

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EEF2K4.81246996
2CDK124.53705809
3MAP3K104.26960383
4TRIB34.13430527
5PKN23.59250373
6SMG13.57523888
7PRPF4B2.79011823
8EPHA22.65791880
9ICK2.64811973
10IRAK32.34432723
11MST1R2.30808073
12NEK22.07011991
13CDC72.04116210
14TTN1.95580989
15SIK21.88697430
16MAP4K11.81285125
17BRD41.73918305
18SCYL21.72527076
19ALK1.71580855
20BMX1.67186995
21PTK61.58757433
22RIPK11.54315645
23MTOR1.53991077
24CDK41.42054502
25TYRO31.33821606
26PDGFRA1.31682281
27CAMK1G1.27198399
28PRKD31.26698478
29CAMK1D1.23819117
30NME21.22237337
31ERN11.21243563
32RPS6KB21.18456230
33SIK11.17171675
34TAOK11.11592285
35MAP3K131.09721498
36GRK61.07012377
37MET1.06233577
38MAP3K71.06041669
39LRRK21.05160500
40STK100.99085531
41PAK40.93297360
42TESK10.92527445
43PASK0.88898746
44CHEK10.87216879
45PAK20.86763728
46DMPK0.85945400
47NTRK10.85168239
48MAP3K30.84613361
49NEK10.83922002
50MAP3K60.83354927
51CDK70.83285165
52TAOK20.81870155
53PDPK10.81302332
54MAP3K80.81253087
55IRAK20.78876304
56RET0.78624211
57ATR0.77595211
58CDK60.76235629
59MAP3K110.75739761
60FLT30.73496200
61MAP3K10.73130236
62RPS6KC10.72872400
63RPS6KL10.72872400
64PDGFRB0.72775649
65CDK20.72069156
66MAP2K20.71284360
67MARK20.70784746
68TTK0.70414261
69PAK60.70180904
70LATS20.69977811
71PRKCH0.69809836
72MAPK110.69416489
73MAP3K90.68866298
74TSSK60.62596051
75CDC42BPA0.59743753
76LMTK20.59481949
77SIK30.58493743
78IRAK40.58302225
79EPHB10.57313817
80KSR20.57002383
81CDK90.56249864
82MAP3K40.56142707
83ATM0.56083207
84STK110.55983697
85STK40.55457993
86FGFR10.55206005
87CAMKK10.54473385
88HCK0.53495827
89RPS6KA10.52542092
90CSF1R0.52311136
91ARAF0.52310589
92CLK10.52253635
93JAK30.51969470
94TESK20.51639943
95CSNK1D0.50551624
96RPS6KA20.50333470
97DDR20.50223957
98RPS6KA60.49987172
99PTK20.48790979
100CDK10.47845922
101CSNK1E0.47615005
102AKT20.47391718
103PRKDC0.46997447
104TBK10.46699724
105NTRK20.46510498
106FGFR30.46321870
107PIM10.44158629
108HIPK20.43872815
109MAPK120.42987599
110FGFR40.42982313
111MAPK140.42726642
112PRKG20.42698543
113BRAF0.42415606
114SGK30.42087241
115GSK3B0.41487431
116MAP3K20.41244457
117LATS10.41194787
118WEE10.41114051
119TRPM70.40255067
120PLK10.39758564
121MAPK80.39336727
122MAP2K30.39115589
123FES0.38933921
124PNCK0.38662649
125RIPK40.38387885
126MAPK10.37569186
127STK380.36722058
128PRKD20.36416302
129CHEK20.36000796
130TNK20.35810019
131ZAP700.35095328
132PDK10.34759684
133KSR10.34497507
134ILK0.31201962
135MAPKAPK30.30752365
136MAPKAPK20.30668701
137CHUK0.30262933
138MAPK100.29230056
139MAP3K140.27507886
140MAPK70.26516728

Predicted pathways (KEGG)

RankGene SetZ-score
1Other glycan degradation_Homo sapiens_hsa005112.22263037
2mTOR signaling pathway_Homo sapiens_hsa041501.93017681
3Chronic myeloid leukemia_Homo sapiens_hsa052201.89748875
4Lysine degradation_Homo sapiens_hsa003101.81992218
5Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.79962152
6mRNA surveillance pathway_Homo sapiens_hsa030151.76539631
7Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.70129416
8Non-small cell lung cancer_Homo sapiens_hsa052231.65884701
9Central carbon metabolism in cancer_Homo sapiens_hsa052301.59137720
10Thyroid hormone signaling pathway_Homo sapiens_hsa049191.55327441
11RNA transport_Homo sapiens_hsa030131.54712956
12Glioma_Homo sapiens_hsa052141.53482839
13DNA replication_Homo sapiens_hsa030301.45976624
14Notch signaling pathway_Homo sapiens_hsa043301.45634367
15Pentose phosphate pathway_Homo sapiens_hsa000301.44360453
16B cell receptor signaling pathway_Homo sapiens_hsa046621.42013759
17Acute myeloid leukemia_Homo sapiens_hsa052211.39474941
18Endometrial cancer_Homo sapiens_hsa052131.34573081
19Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.33363114
20Neurotrophin signaling pathway_Homo sapiens_hsa047221.32740824
21Fructose and mannose metabolism_Homo sapiens_hsa000511.32404543
22Spliceosome_Homo sapiens_hsa030401.31386234
23Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.31000146
24VEGF signaling pathway_Homo sapiens_hsa043701.28183098
25MicroRNAs in cancer_Homo sapiens_hsa052061.28005903
26Colorectal cancer_Homo sapiens_hsa052101.27618639
27Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.26299164
28Cell cycle_Homo sapiens_hsa041101.25341350
29Mismatch repair_Homo sapiens_hsa034301.25027552
30Small cell lung cancer_Homo sapiens_hsa052221.24901385
31Prion diseases_Homo sapiens_hsa050201.20254441
32Type II diabetes mellitus_Homo sapiens_hsa049301.20002489
33HTLV-I infection_Homo sapiens_hsa051661.19298186
34One carbon pool by folate_Homo sapiens_hsa006701.17559582
35Proteoglycans in cancer_Homo sapiens_hsa052051.17495196
36Estrogen signaling pathway_Homo sapiens_hsa049151.17261198
37Dorso-ventral axis formation_Homo sapiens_hsa043201.16640560
38Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.16268546
39Viral carcinogenesis_Homo sapiens_hsa052031.15822804
40Biosynthesis of amino acids_Homo sapiens_hsa012301.12171919
41Glycosaminoglycan degradation_Homo sapiens_hsa005311.11623267
42ECM-receptor interaction_Homo sapiens_hsa045121.11336233
43Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.10366180
44Longevity regulating pathway - mammal_Homo sapiens_hsa042111.09389767
45Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.06989042
46Focal adhesion_Homo sapiens_hsa045101.06892879
47Oocyte meiosis_Homo sapiens_hsa041141.03917404
48AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.03805433
49Renal cell carcinoma_Homo sapiens_hsa052111.03679167
50Insulin resistance_Homo sapiens_hsa049311.03473274
51Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.03094966
52Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.01038685
53Pancreatic cancer_Homo sapiens_hsa052121.00352273
54Galactose metabolism_Homo sapiens_hsa000520.99532745
55Phosphatidylinositol signaling system_Homo sapiens_hsa040700.98644539
56HIF-1 signaling pathway_Homo sapiens_hsa040660.97745410
57Adherens junction_Homo sapiens_hsa045200.97343433
58T cell receptor signaling pathway_Homo sapiens_hsa046600.95474647
59Primary immunodeficiency_Homo sapiens_hsa053400.94779255
60Insulin signaling pathway_Homo sapiens_hsa049100.94391769
61Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.94235142
62Carbohydrate digestion and absorption_Homo sapiens_hsa049730.93799983
63AMPK signaling pathway_Homo sapiens_hsa041520.92618505
64Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.92182946
65ErbB signaling pathway_Homo sapiens_hsa040120.92101407
66Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.88433951
67Viral myocarditis_Homo sapiens_hsa054160.87674566
68Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.86440910
69Phospholipase D signaling pathway_Homo sapiens_hsa040720.86382660
70Hepatitis C_Homo sapiens_hsa051600.85895100
71Base excision repair_Homo sapiens_hsa034100.84576183
72Basal cell carcinoma_Homo sapiens_hsa052170.83956381
73Platelet activation_Homo sapiens_hsa046110.83893882
74Leukocyte transendothelial migration_Homo sapiens_hsa046700.82849188
75Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.82669122
76Hippo signaling pathway_Homo sapiens_hsa043900.81915159
77Long-term potentiation_Homo sapiens_hsa047200.79796664
78Regulation of actin cytoskeleton_Homo sapiens_hsa048100.79716679
792-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.79591317
80Prolactin signaling pathway_Homo sapiens_hsa049170.79222777
81Glucagon signaling pathway_Homo sapiens_hsa049220.78490474
82Prostate cancer_Homo sapiens_hsa052150.78341629
83Aldosterone synthesis and secretion_Homo sapiens_hsa049250.78134493
84Melanogenesis_Homo sapiens_hsa049160.77814739
85Bladder cancer_Homo sapiens_hsa052190.77481560
86Transcriptional misregulation in cancer_Homo sapiens_hsa052020.76916461
87Pathways in cancer_Homo sapiens_hsa052000.74669513
88Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.73892336
89Thyroid cancer_Homo sapiens_hsa052160.72359879
90Osteoclast differentiation_Homo sapiens_hsa043800.71851146
91FoxO signaling pathway_Homo sapiens_hsa040680.71088050
92Inositol phosphate metabolism_Homo sapiens_hsa005620.70870694
93Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.70819105
94Hepatitis B_Homo sapiens_hsa051610.70768814
95MAPK signaling pathway_Homo sapiens_hsa040100.70084151
96Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.69686902
97Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.69612368
98cGMP-PKG signaling pathway_Homo sapiens_hsa040220.68401509
99Dilated cardiomyopathy_Homo sapiens_hsa054140.67708533
100Sphingolipid signaling pathway_Homo sapiens_hsa040710.67599792
101Toxoplasmosis_Homo sapiens_hsa051450.67477893
102Oxytocin signaling pathway_Homo sapiens_hsa049210.66365529
103Rap1 signaling pathway_Homo sapiens_hsa040150.66356679
104Amoebiasis_Homo sapiens_hsa051460.65877495
105Vitamin B6 metabolism_Homo sapiens_hsa007500.65814693
106GnRH signaling pathway_Homo sapiens_hsa049120.65553049
107Toll-like receptor signaling pathway_Homo sapiens_hsa046200.65073826
108Gap junction_Homo sapiens_hsa045400.64347523
109Alcoholism_Homo sapiens_hsa050340.64178837
110Choline metabolism in cancer_Homo sapiens_hsa052310.63906669
111Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.63804248
112Antigen processing and presentation_Homo sapiens_hsa046120.62864726
113Apoptosis_Homo sapiens_hsa042100.61778583
114Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.61261912
115Adipocytokine signaling pathway_Homo sapiens_hsa049200.61163359
116Epstein-Barr virus infection_Homo sapiens_hsa051690.60663710
117Cyanoamino acid metabolism_Homo sapiens_hsa004600.60364868
118Influenza A_Homo sapiens_hsa051640.59910509
119Systemic lupus erythematosus_Homo sapiens_hsa053220.59670427
120Gastric acid secretion_Homo sapiens_hsa049710.59363542
121Tight junction_Homo sapiens_hsa045300.59149474
122TNF signaling pathway_Homo sapiens_hsa046680.58978150
123Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.58250883
124Sulfur relay system_Homo sapiens_hsa041220.57551116
125Axon guidance_Homo sapiens_hsa043600.57357690
126Endocytosis_Homo sapiens_hsa041440.57236156
127Fatty acid biosynthesis_Homo sapiens_hsa000610.52106617
128Vibrio cholerae infection_Homo sapiens_hsa051100.51994851
129Shigellosis_Homo sapiens_hsa051310.50964152
130Melanoma_Homo sapiens_hsa052180.50539770
131N-Glycan biosynthesis_Homo sapiens_hsa005100.49275897
132Carbon metabolism_Homo sapiens_hsa012000.48841124

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