INTS10

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: INTS10 is a subunit of the Integrator complex, which associates with the C-terminal domain of RNA polymerase II large subunit (POLR2A; MIM 180660) and mediates 3-prime end processing of small nuclear RNAs U1 (RNU1; MIM 180680) and U2 (RNU2; MIM 180690) (Baillat et al., 2005 [PubMed 16239144]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1deoxyribonucleoside monophosphate metabolic process (GO:0009162)5.48150948
2maturation of 5.8S rRNA (GO:0000460)4.34641517
3regulation of nuclear cell cycle DNA replication (GO:0033262)3.98806576
4mitochondrial DNA replication (GO:0006264)3.98624797
5histone H2A acetylation (GO:0043968)3.98104684
6ribosome biogenesis (GO:0042254)3.86245593
7oxidative phosphorylation (GO:0006119)3.86117386
8microtubule depolymerization (GO:0007019)3.85849693
9piRNA metabolic process (GO:0034587)3.83474398
10ubiquinone biosynthetic process (GO:0006744)3.83450959
11ribosome assembly (GO:0042255)3.68459060
12rRNA catabolic process (GO:0016075)3.60036841
13acrosome assembly (GO:0001675)3.54073651
14cilium or flagellum-dependent cell motility (GO:0001539)3.53200696
15DNA replication initiation (GO:0006270)3.47810594
16purine nucleobase biosynthetic process (GO:0009113)3.47463410
17pore complex assembly (GO:0046931)3.47118177
18regulation of centriole replication (GO:0046599)3.40921707
19male meiosis (GO:0007140)3.39765263
20IMP biosynthetic process (GO:0006188)3.38604390
21ubiquinone metabolic process (GO:0006743)3.38041188
22telomere maintenance via semi-conservative replication (GO:0032201)3.36760777
23mitochondrial RNA metabolic process (GO:0000959)3.36269754
24DNA strand elongation involved in DNA replication (GO:0006271)3.33141443
25nucleobase biosynthetic process (GO:0046112)3.33061248
26DNA methylation involved in gamete generation (GO:0043046)3.32292849
27tRNA aminoacylation for protein translation (GO:0006418)3.29594861
28mRNA splice site selection (GO:0006376)3.27637065
29ribonucleoprotein complex biogenesis (GO:0022613)3.27033460
30tRNA aminoacylation (GO:0043039)3.24767859
31amino acid activation (GO:0043038)3.24767859
32folic acid-containing compound biosynthetic process (GO:0009396)3.24723647
33positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.23153241
34somatic hypermutation of immunoglobulin genes (GO:0016446)3.22880338
35somatic diversification of immune receptors via somatic mutation (GO:0002566)3.22880338
36pseudouridine synthesis (GO:0001522)3.22470275
37nuclear pore organization (GO:0006999)3.21803873
38quinone biosynthetic process (GO:1901663)3.21571384
39nucleotide-excision repair, DNA gap filling (GO:0006297)3.21410544
40mitochondrial DNA metabolic process (GO:0032042)3.21104368
41tricarboxylic acid cycle (GO:0006099)3.20507027
42DNA strand elongation (GO:0022616)3.16502755
43binding of sperm to zona pellucida (GO:0007339)3.13639484
44DNA unwinding involved in DNA replication (GO:0006268)3.13331041
45sperm-egg recognition (GO:0035036)3.11475744
46deoxyribose phosphate catabolic process (GO:0046386)3.06346261
47mitotic sister chromatid cohesion (GO:0007064)3.05494395
48DNA-dependent DNA replication (GO:0006261)3.01367311
49telomere maintenance via recombination (GO:0000722)2.97292783
50transcription from mitochondrial promoter (GO:0006390)2.97155475
51viral mRNA export from host cell nucleus (GO:0046784)2.96026406
52mismatch repair (GO:0006298)2.94862839
53regulation of centrosome cycle (GO:0046605)2.93354708
54L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.91521599
55positive regulation of protein sumoylation (GO:0033235)2.91315913
56chromatin remodeling at centromere (GO:0031055)2.91279090
57DNA replication-independent nucleosome organization (GO:0034724)2.90993740
58DNA replication-independent nucleosome assembly (GO:0006336)2.90993740
59histone exchange (GO:0043486)2.89794424
60rRNA modification (GO:0000154)2.89710702
61purine deoxyribonucleotide catabolic process (GO:0009155)2.89630884
62establishment of integrated proviral latency (GO:0075713)2.89194323
63RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.88894711
64branched-chain amino acid catabolic process (GO:0009083)2.88873665
65protein localization to kinetochore (GO:0034501)2.87550480
66formation of translation preinitiation complex (GO:0001731)2.87042629
67regulation of cilium movement (GO:0003352)2.86955196
68negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.86678944
69negative regulation of sister chromatid segregation (GO:0033046)2.86678944
70negative regulation of mitotic sister chromatid separation (GO:2000816)2.86678944
71negative regulation of mitotic sister chromatid segregation (GO:0033048)2.86678944
72DNA duplex unwinding (GO:0032508)2.86670182
73IMP metabolic process (GO:0046040)2.86503818
74mitotic recombination (GO:0006312)2.85869399
75negative regulation of chromosome segregation (GO:0051985)2.85443150
76DNA geometric change (GO:0032392)2.85410794
77dosage compensation (GO:0007549)2.85404782
78deoxyribonucleotide catabolic process (GO:0009264)2.84326504
79attachment of spindle microtubules to kinetochore (GO:0008608)2.84029620
80replication fork processing (GO:0031297)2.83578018
81spermatid development (GO:0007286)2.83409208
82DNA replication checkpoint (GO:0000076)2.83327499
83rRNA processing (GO:0006364)2.83175095
84CENP-A containing nucleosome assembly (GO:0034080)2.83087794
85motile cilium assembly (GO:0044458)2.83018982
86regulation of relaxation of muscle (GO:1901077)2.81955938
87spindle assembly checkpoint (GO:0071173)2.81769378
88protein K6-linked ubiquitination (GO:0085020)2.80828530
89mitotic sister chromatid segregation (GO:0000070)2.80726097
90rRNA metabolic process (GO:0016072)2.80125884
91carnitine transport (GO:0015879)2.79867270
92amino-acid betaine transport (GO:0015838)2.79867270
93carnitine transmembrane transport (GO:1902603)2.79268374
94kinetochore organization (GO:0051383)2.79027272
95cell-cell recognition (GO:0009988)2.78819184
96regulation of DNA endoreduplication (GO:0032875)2.77821235
97maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.77692900
98pteridine-containing compound biosynthetic process (GO:0042559)2.77516974
99regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.77316262
100negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.76942950
101sister chromatid segregation (GO:0000819)2.76445278
102mitotic spindle assembly checkpoint (GO:0007094)2.75926088
103telomere maintenance via telomere lengthening (GO:0010833)2.75746146
104gene silencing by RNA (GO:0031047)2.75144650
105succinate metabolic process (GO:0006105)2.75007649
106cullin deneddylation (GO:0010388)2.74096454
107protein deneddylation (GO:0000338)2.73774563
108regulation of translational fidelity (GO:0006450)2.73099768
109epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.72810612
110positive regulation of granulocyte differentiation (GO:0030854)2.72564374
111pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.72352476
112branched-chain amino acid metabolic process (GO:0009081)2.72048488
113NADH metabolic process (GO:0006734)2.71813661
114regulation of centrosome duplication (GO:0010824)2.71803709
115tRNA metabolic process (GO:0006399)2.71389594
116synaptonemal complex assembly (GO:0007130)2.71148353
117interkinetic nuclear migration (GO:0022027)2.70341264
118histone arginine methylation (GO:0034969)2.70193029
119peptidyl-arginine N-methylation (GO:0035246)2.69148824
120peptidyl-arginine methylation (GO:0018216)2.69148824
121protein localization to chromosome, centromeric region (GO:0071459)2.68771684
122deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.68632200
123sperm motility (GO:0030317)2.67922595
124ribosomal large subunit biogenesis (GO:0042273)2.67261351
125peptidyl-arginine omega-N-methylation (GO:0035247)2.67163459
126aerobic respiration (GO:0009060)2.65432859
127tetrahydrofolate metabolic process (GO:0046653)2.65284853
128non-recombinational repair (GO:0000726)2.64459970
129double-strand break repair via nonhomologous end joining (GO:0006303)2.64459970
130nuclear pore complex assembly (GO:0051292)2.63946148
131regulation of sister chromatid segregation (GO:0033045)2.63324623
132regulation of mitotic sister chromatid separation (GO:0010965)2.63324623
133regulation of mitotic sister chromatid segregation (GO:0033047)2.63324623
134intra-S DNA damage checkpoint (GO:0031573)2.62713471
135DNA replication-dependent nucleosome organization (GO:0034723)2.62424144
136DNA replication-dependent nucleosome assembly (GO:0006335)2.62424144
137synaptonemal complex organization (GO:0070193)2.60862819
138cellular component biogenesis (GO:0044085)2.60449473
139meiotic chromosome segregation (GO:0045132)2.60192717
140RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.59894676
141tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.59894676
142rRNA methylation (GO:0031167)2.59648545
143regulation of cardiac muscle cell contraction (GO:0086004)2.58793737
144pre-miRNA processing (GO:0031054)2.58301099
145spindle checkpoint (GO:0031577)2.58280816
146striatum development (GO:0021756)2.58243091
147regulation of chromosome segregation (GO:0051983)2.57957438
148cellular respiration (GO:0045333)2.57593375
149fusion of sperm to egg plasma membrane (GO:0007342)2.57205513
150chromosome organization involved in meiosis (GO:0070192)2.56710255
151regulation of telomere maintenance (GO:0032204)2.56346803
152mitotic spindle checkpoint (GO:0071174)2.56275002
153pyrimidine-containing compound salvage (GO:0008655)2.55532225
154pyrimidine nucleoside salvage (GO:0043097)2.55532225
155regulation of mitotic metaphase/anaphase transition (GO:0030071)2.55334807
156meiotic nuclear division (GO:0007126)2.54926756
157methionine biosynthetic process (GO:0009086)2.54920475
158kinetochore assembly (GO:0051382)2.54582119
159oxaloacetate metabolic process (GO:0006107)2.50844306
160regulation of mitochondrial translation (GO:0070129)2.50470722
161* ncRNA metabolic process (GO:0034660)2.49958259
162tRNA processing (GO:0008033)2.49799607
163metallo-sulfur cluster assembly (GO:0031163)2.49408863
164iron-sulfur cluster assembly (GO:0016226)2.49408863
165somatic recombination of immunoglobulin gene segments (GO:0016447)2.48854259
166energy homeostasis (GO:0097009)2.48347988
167spliceosomal snRNP assembly (GO:0000387)2.47602976
168respiratory chain complex IV assembly (GO:0008535)2.47596501
169folic acid-containing compound metabolic process (GO:0006760)2.46804224
170* ncRNA processing (GO:0034470)2.46752591
171aspartate family amino acid biosynthetic process (GO:0009067)2.45428649
172regulation of actin filament-based movement (GO:1903115)2.45004870
173negative regulation of phosphoprotein phosphatase activity (GO:0032515)2.44411764
174somatic diversification of immunoglobulins (GO:0016445)2.43165316
175valine metabolic process (GO:0006573)2.43141424
176carnitine shuttle (GO:0006853)2.42634036
177base-excision repair, AP site formation (GO:0006285)2.42376314
178histone mRNA metabolic process (GO:0008334)2.40649596
179GMP metabolic process (GO:0046037)2.40562928
180L-methionine biosynthetic process (GO:0071265)2.40414805
181amino acid salvage (GO:0043102)2.40414805

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.63594881
2MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse5.07173874
3EZH2_22144423_ChIP-Seq_EOC_Human3.29832858
4E2F4_17652178_ChIP-ChIP_JURKAT_Human3.20017178
5ELF1_17652178_ChIP-ChIP_JURKAT_Human3.14750103
6MYCN_21190229_ChIP-Seq_SHEP-21N_Human3.02331509
7E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.94131411
8RBPJ_22232070_ChIP-Seq_NCS_Mouse2.82432713
9FOXM1_23109430_ChIP-Seq_U2OS_Human2.73631505
10* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.69708049
11FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.58726944
12GBX2_23144817_ChIP-Seq_PC3_Human2.56934012
13CREB1_15753290_ChIP-ChIP_HEK293T_Human2.54385944
14ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.52445877
15SRF_21415370_ChIP-Seq_HL-1_Mouse2.34680438
16KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.29136570
17MYC_18555785_ChIP-Seq_MESCs_Mouse2.23971867
18HOXB4_20404135_ChIP-ChIP_EML_Mouse2.09314856
19GATA1_22025678_ChIP-Seq_K562_Human2.08911552
20TP63_19390658_ChIP-ChIP_HaCaT_Human2.08433996
21GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.02703597
22CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.01537577
23YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.95408595
24ELK1_19687146_ChIP-ChIP_HELA_Human1.89231955
25SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.88459758
26CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.84968703
27FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.82838929
28HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.78872166
29BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.74466293
30FUS_26573619_Chip-Seq_HEK293_Human1.72272265
31E2F1_18555785_ChIP-Seq_MESCs_Mouse1.71046589
32THAP11_20581084_ChIP-Seq_MESCs_Mouse1.70851946
33E2F1_21310950_ChIP-Seq_MCF-7_Human1.67479016
34CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.64596723
35MYC_19030024_ChIP-ChIP_MESCs_Mouse1.63030774
36EWS_26573619_Chip-Seq_HEK293_Human1.61599216
37ERG_20887958_ChIP-Seq_HPC-7_Mouse1.61413207
38ZFX_18555785_ChIP-Seq_MESCs_Mouse1.60598617
39BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.59859316
40IGF1R_20145208_ChIP-Seq_DFB_Human1.58716583
41EST1_17652178_ChIP-ChIP_JURKAT_Human1.56374662
42KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.55931402
43* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.53229540
44TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.53086545
45SALL1_21062744_ChIP-ChIP_HESCs_Human1.50718072
46MYC_19079543_ChIP-ChIP_MESCs_Mouse1.50414420
47* PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.48628578
48* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.48021966
49TFEB_21752829_ChIP-Seq_HELA_Human1.47974984
50KDM5A_27292631_Chip-Seq_BREAST_Human1.44271279
51NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.44228462
52FLI1_27457419_Chip-Seq_LIVER_Mouse1.42674624
53HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.40093994
54PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.39514382
55* PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.39281750
56GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.38932596
57* CIITA_25753668_ChIP-Seq_RAJI_Human1.38716440
58JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.38536354
59TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.36793252
60SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.35343188
61SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.34729215
62AR_21909140_ChIP-Seq_LNCAP_Human1.33989364
63PCGF2_27294783_Chip-Seq_ESCs_Mouse1.33066906
64MYB_26560356_Chip-Seq_TH2_Human1.31948363
65MYCN_18555785_ChIP-Seq_MESCs_Mouse1.31775690
66ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.30372627
67SOX9_26525672_Chip-Seq_HEART_Mouse1.28956181
68TAF15_26573619_Chip-Seq_HEK293_Human1.28407866
69* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.28189987
70FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.28012902
71PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.27787743
72HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.25690266
73HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.24642098
74TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.23294526
75ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.22586221
76POU3F2_20337985_ChIP-ChIP_501MEL_Human1.20942483
77MYC_18940864_ChIP-ChIP_HL60_Human1.20386727
78EGR1_23403033_ChIP-Seq_LIVER_Mouse1.20208092
79ETS1_20019798_ChIP-Seq_JURKAT_Human1.19944349
80ZFP57_27257070_Chip-Seq_ESCs_Mouse1.19422165
81NELFA_20434984_ChIP-Seq_ESCs_Mouse1.19188189
82CTBP2_25329375_ChIP-Seq_LNCAP_Human1.16220365
83PCGF2_27294783_Chip-Seq_NPCs_Mouse1.15763937
84E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.14827638
85NOTCH1_21737748_ChIP-Seq_TLL_Human1.14019643
86POU5F1_16153702_ChIP-ChIP_HESCs_Human1.13773537
87* CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.13599480
88REST_21632747_ChIP-Seq_MESCs_Mouse1.11404499
89RNF2_27304074_Chip-Seq_NSC_Mouse1.11307707
90IRF8_22096565_ChIP-ChIP_GC-B_Human1.10983905
91* FOXP3_21729870_ChIP-Seq_TREG_Human1.09654688
92PADI4_21655091_ChIP-ChIP_MCF-7_Human1.09384863
93YY1_21170310_ChIP-Seq_MESCs_Mouse1.08748244
94EGR1_19374776_ChIP-ChIP_THP-1_Human1.06916216
95DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.06841319
96TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.06300657
97ZNF274_21170338_ChIP-Seq_K562_Hela1.06214084
98KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.04758535
99KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.04758535
100KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.04758535
101GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.04171970
102* POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.03566491
103CBX2_27304074_Chip-Seq_ESCs_Mouse1.03005671
104* VDR_23849224_ChIP-Seq_CD4+_Human1.02747204
105PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.02468702
106RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.00197689
107HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.00082614
108GABP_19822575_ChIP-Seq_HepG2_Human0.97759151
109CTBP1_25329375_ChIP-Seq_LNCAP_Human0.96883469
110SCL_19346495_ChIP-Seq_HPC-7_Human0.96122604
111TTF2_22483619_ChIP-Seq_HELA_Human0.95850391
112TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.95189982
113SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.94961497
114SOX2_18555785_ChIP-Seq_MESCs_Mouse0.94929602
115SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.94135331
116P300_19829295_ChIP-Seq_ESCs_Human0.92476627
117E2F1_18555785_Chip-Seq_ESCs_Mouse0.92360104
118MYB_26560356_Chip-Seq_TH1_Human0.92148986
119DCP1A_22483619_ChIP-Seq_HELA_Human0.91985046
120NANOG_18555785_Chip-Seq_ESCs_Mouse0.91723161
121SPI1_23547873_ChIP-Seq_NB4_Human0.91462093
122SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.90543757
123* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.90475448
124SUZ12_27294783_Chip-Seq_NPCs_Mouse0.90211589
125IRF1_19129219_ChIP-ChIP_H3396_Human0.89242335
126GABP_17652178_ChIP-ChIP_JURKAT_Human0.88758257
127P53_22387025_ChIP-Seq_ESCs_Mouse0.88371922
128CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.87848227
129P300_18555785_Chip-Seq_ESCs_Mouse0.87377216
130NFE2_27457419_Chip-Seq_LIVER_Mouse0.86632975
131GATA4_21415370_ChIP-Seq_HL-1_Mouse0.86547349
132STAT3_18555785_Chip-Seq_ESCs_Mouse0.86204219
133SOX2_16153702_ChIP-ChIP_HESCs_Human0.85406006
134SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.85098273
135SMAD4_21799915_ChIP-Seq_A2780_Human0.84669016
136CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.84117181
137XRN2_22483619_ChIP-Seq_HELA_Human0.83854603
138CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.83796338
139TCF4_23295773_ChIP-Seq_U87_Human0.83758132
140SUZ12_18555785_Chip-Seq_ESCs_Mouse0.83527308
141NANOG_18555785_ChIP-Seq_MESCs_Mouse0.82980157
142CMYC_18555785_Chip-Seq_ESCs_Mouse0.82437980
143EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.82357417
144ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.81625187
145NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.81522066
146CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.81385725
147POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.80748695
148* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.80652739
149CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.79383814
150ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.78523491
151GATA3_26560356_Chip-Seq_TH2_Human0.74668258
152FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.73587302

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008877_abnormal_DNA_methylation4.43741047
2MP0003787_abnormal_imprinting3.57994906
3MP0010094_abnormal_chromosome_stability3.41847643
4MP0002009_preneoplasia3.29551436
5MP0005410_abnormal_fertilization3.09440676
6MP0009697_abnormal_copulation2.91759348
7MP0008058_abnormal_DNA_repair2.91420243
8MP0008057_abnormal_DNA_replication2.87095855
9MP0002837_dystrophic_cardiac_calcinosis2.76886533
10MP0004859_abnormal_synaptic_plasticity2.69575943
11MP0000372_irregular_coat_pigmentation2.64328620
12MP0001661_extended_life_span2.63775715
13MP0003763_abnormal_thymus_physiology2.60349106
14MP0003646_muscle_fatigue2.57594432
15MP0003111_abnormal_nucleus_morphology2.55619389
16MP0005075_abnormal_melanosome_morpholog2.38311029
17MP0003121_genomic_imprinting2.37592292
18MP0010030_abnormal_orbit_morphology2.35061428
19MP0006292_abnormal_olfactory_placode2.17462518
20MP0002877_abnormal_melanocyte_morpholog2.14917107
21MP0002166_altered_tumor_susceptibility2.14557543
22MP0006036_abnormal_mitochondrial_physio2.13832908
23MP0003693_abnormal_embryo_hatching2.10444292
24MP0001188_hyperpigmentation2.07795443
25MP0003698_abnormal_male_reproductive2.01535190
26MP0003077_abnormal_cell_cycle1.99255393
27MP0003880_abnormal_central_pattern1.94385740
28MP0004084_abnormal_cardiac_muscle1.92503217
29MP0001929_abnormal_gametogenesis1.91974386
30MP0004215_abnormal_myocardial_fiber1.91019679
31MP0004957_abnormal_blastocyst_morpholog1.91012793
32MP0003186_abnormal_redox_activity1.87739630
33MP0008007_abnormal_cellular_replicative1.79580606
34MP0005646_abnormal_pituitary_gland1.77795733
35MP0002210_abnormal_sex_determination1.71976448
36MP0003635_abnormal_synaptic_transmissio1.70119253
37MP0003890_abnormal_embryonic-extraembry1.63029951
38MP0003656_abnormal_erythrocyte_physiolo1.62046297
39MP0003123_paternal_imprinting1.59516308
40MP0009046_muscle_twitch1.52772254
41MP0002160_abnormal_reproductive_system1.51882951
42MP0005670_abnormal_white_adipose1.51495890
43MP0002876_abnormal_thyroid_physiology1.49374494
44MP0004036_abnormal_muscle_relaxation1.49255818
45MP0003786_premature_aging1.47337638
46MP0002269_muscular_atrophy1.47243489
47MP0005408_hypopigmentation1.46161286
48MP0001145_abnormal_male_reproductive1.45296655
49MP0005365_abnormal_bile_salt1.44252145
50MP0008775_abnormal_heart_ventricle1.42220182
51MP0003221_abnormal_cardiomyocyte_apopto1.41420555
52MP0000015_abnormal_ear_pigmentation1.40603736
53MP0002063_abnormal_learning/memory/cond1.40545933
54MP0002006_tumorigenesis1.39757027
55MP0005645_abnormal_hypothalamus_physiol1.36739633
56MP0008932_abnormal_embryonic_tissue1.36658394
57MP0005174_abnormal_tail_pigmentation1.35724819
58MP0002396_abnormal_hematopoietic_system1.34562488
59MP0005423_abnormal_somatic_nervous1.34381697
60MP0004133_heterotaxia1.32521885
61MP0005330_cardiomyopathy1.31469663
62MP0001968_abnormal_touch/_nociception1.31157778
63MP0000566_synostosis1.30337559
64MP0002736_abnormal_nociception_after1.30002604
65MP0000653_abnormal_sex_gland1.28119619
66MP0003122_maternal_imprinting1.25619956
67MP0009745_abnormal_behavioral_response1.25061017
68MP0000778_abnormal_nervous_system1.24457450
69MP0000358_abnormal_cell_content/1.22174085
70MP0006072_abnormal_retinal_apoptosis1.22041729
71MP0008875_abnormal_xenobiotic_pharmacok1.19948990
72MP0002572_abnormal_emotion/affect_behav1.19784388
73MP0002272_abnormal_nervous_system1.18337302
74MP0003718_maternal_effect1.17954316
75MP0004233_abnormal_muscle_weight1.17605343
76MP0001486_abnormal_startle_reflex1.17437763
77MP0004147_increased_porphyrin_level1.17285710
78MP0002019_abnormal_tumor_incidence1.16440179
79MP0000747_muscle_weakness1.14860303
80MP0000703_abnormal_thymus_morphology1.14449893
81MP0005499_abnormal_olfactory_system1.13316079
82MP0005394_taste/olfaction_phenotype1.13316079
83MP0002132_abnormal_respiratory_system1.12681396
84MP0002161_abnormal_fertility/fecundity1.12327070
85MP0004270_analgesia1.12105407
86MP0002064_seizures1.11552991
87MP0000955_abnormal_spinal_cord1.11458908
88MP0002734_abnormal_mechanical_nocicepti1.09152052
89MP0006035_abnormal_mitochondrial_morpho1.08720650
90MP0003632_abnormal_nervous_system1.07258651
91MP0001529_abnormal_vocalization1.06517874
92MP0002184_abnormal_innervation1.06203420
93MP0005248_abnormal_Harderian_gland1.05119100
94MP0004811_abnormal_neuron_physiology1.01760293
95MP0003861_abnormal_nervous_system1.01100904
96MP0000631_abnormal_neuroendocrine_gland1.01093774
97MP0003283_abnormal_digestive_organ1.00312099
98MP0005389_reproductive_system_phenotype0.99943503
99MP0000465_gastrointestinal_hemorrhage0.99941288
100MP0000350_abnormal_cell_proliferation0.99870204
101MP0005551_abnormal_eye_electrophysiolog0.98957049
102MP0005253_abnormal_eye_physiology0.98820550
103MP0001293_anophthalmia0.98799175
104MP0005636_abnormal_mineral_homeostasis0.98638256
105MP0001764_abnormal_homeostasis0.96629691
106MP0001986_abnormal_taste_sensitivity0.96197800
107MP0004484_altered_response_of0.95910030
108MP0001873_stomach_inflammation0.95301164
109MP0005409_darkened_coat_color0.95008446
110MP0002095_abnormal_skin_pigmentation0.94567597
111MP0009333_abnormal_splenocyte_physiolog0.93834345
112MP0002067_abnormal_sensory_capabilities0.93599245
113MP0002398_abnormal_bone_marrow0.93097397
114MP0005397_hematopoietic_system_phenotyp0.92248821
115MP0001545_abnormal_hematopoietic_system0.92248821
116MP0002102_abnormal_ear_morphology0.91674887
117MP0002152_abnormal_brain_morphology0.91063991
118MP0002722_abnormal_immune_system0.90287952
119MP0002557_abnormal_social/conspecific_i0.90275238
120MP0000689_abnormal_spleen_morphology0.90052208
121MP0002822_catalepsy0.89627907
122MP0001485_abnormal_pinna_reflex0.88280829
123MP0002139_abnormal_hepatobiliary_system0.88018479
124MP0008995_early_reproductive_senescence0.87941233
125MP0001984_abnormal_olfaction0.87925750
126MP0001853_heart_inflammation0.87819674
127MP0006138_congestive_heart_failure0.86952214
128MP0005266_abnormal_metabolism0.85719687
129MP0010307_abnormal_tumor_latency0.85450237
130MP0009763_increased_sensitivity_to0.85008216
131MP0000049_abnormal_middle_ear0.84440039
132MP0008789_abnormal_olfactory_epithelium0.82604712
133MP0002085_abnormal_embryonic_tissue0.82414906
134MP0005671_abnormal_response_to0.82065889
135MP0002249_abnormal_larynx_morphology0.81141625
136MP0004381_abnormal_hair_follicle0.80929709
137MP0000751_myopathy0.80112825
138MP0002882_abnormal_neuron_morphology0.80038377
139MP0002735_abnormal_chemical_nociception0.79714365
140MP0003567_abnormal_fetal_cardiomyocyte0.79673217
141MP0002751_abnormal_autonomic_nervous0.78863817
142MP0005647_abnormal_sex_gland0.78003156
143MP0001730_embryonic_growth_arrest0.76690328
144MP0001851_eye_inflammation0.76586744
145MP0003631_nervous_system_phenotype0.75647802
146MP0000598_abnormal_liver_morphology0.75395892
147MP0005386_behavior/neurological_phenoty0.74428997
148MP0004924_abnormal_behavior0.74428997
149MP0001835_abnormal_antigen_presentation0.74216582
150MP0002405_respiratory_system_inflammati0.74085762
151MP0002084_abnormal_developmental_patter0.74055053
152MP0002080_prenatal_lethality0.72973469
153MP0001697_abnormal_embryo_size0.72677703
154MP0002653_abnormal_ependyma_morphology0.72219182
155MP0004808_abnormal_hematopoietic_stem0.72032532
156MP0002088_abnormal_embryonic_growth/wei0.71726483
157MP0005165_increased_susceptibility_to0.70996409
158MP0002429_abnormal_blood_cell0.70990811
159MP0005380_embryogenesis_phenotype0.70898056
160MP0001672_abnormal_embryogenesis/_devel0.70898056
161MP0003984_embryonic_growth_retardation0.70777019
162MP0001119_abnormal_female_reproductive0.70186005
163MP0003195_calcinosis0.69434937
164MP0000313_abnormal_cell_death0.69286540
165MP0005319_abnormal_enzyme/_coenzyme0.69262797
166MP0005332_abnormal_amino_acid0.69109448
167MP0002752_abnormal_somatic_nervous0.68467308
168MP0000609_abnormal_liver_physiology0.68447623
169MP0000716_abnormal_immune_system0.67771865
170MP0008873_increased_physiological_sensi0.67632199
171MP0003806_abnormal_nucleotide_metabolis0.67590930
172MP0005171_absent_coat_pigmentation0.66904731

Predicted human phenotypes

RankGene SetZ-score
1Progressive inability to walk (HP:0002505)4.53906275
2Chromosomal breakage induced by crosslinking agents (HP:0003221)4.16562225
3Microvesicular hepatic steatosis (HP:0001414)3.90586341
4Dynein arm defect of respiratory motile cilia (HP:0012255)3.81322092
5Absent/shortened dynein arms (HP:0200106)3.81322092
6Chromsome breakage (HP:0040012)3.76594600
7Volvulus (HP:0002580)3.65091696
8Type I transferrin isoform profile (HP:0003642)3.43736697
9Facial diplegia (HP:0001349)3.37693738
10Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.31504014
11Abnormal protein glycosylation (HP:0012346)3.21747524
12Abnormal glycosylation (HP:0012345)3.21747524
13Abnormal isoelectric focusing of serum transferrin (HP:0003160)3.21747524
14Abnormal protein N-linked glycosylation (HP:0012347)3.21747524
15Myoglobinuria (HP:0002913)3.13338034
16Increased serum lactate (HP:0002151)3.10921594
17Abnormality of the heme biosynthetic pathway (HP:0010472)3.06458716
18Bundle branch block (HP:0011710)3.05147830
19Inability to walk (HP:0002540)3.04568757
20Reduced antithrombin III activity (HP:0001976)2.99728816
21Hepatic necrosis (HP:0002605)2.98310202
22Rhabdomyolysis (HP:0003201)2.91725134
23Febrile seizures (HP:0002373)2.87673712
24Hepatocellular necrosis (HP:0001404)2.87598402
25Renal cortical cysts (HP:0000803)2.84160251
26Lactic acidosis (HP:0003128)2.83011213
27Increased intramyocellular lipid droplets (HP:0012240)2.79894265
28Birth length less than 3rd percentile (HP:0003561)2.77393531
29Hyperammonemia (HP:0001987)2.74196706
30Medulloblastoma (HP:0002885)2.71346978
31Abnormal lung lobation (HP:0002101)2.71210306
32Abnormality of B cell number (HP:0010975)2.71021137
33Sudden death (HP:0001699)2.66337794
34Increased serum pyruvate (HP:0003542)2.65362534
35Severe combined immunodeficiency (HP:0004430)2.62810983
36Aplasia/Hypoplasia of the uvula (HP:0010293)2.61837936
37Increased CSF lactate (HP:0002490)2.60730620
38Protruding tongue (HP:0010808)2.60512633
39Ragged-red muscle fibers (HP:0003200)2.60233539
40Abnormal respiratory epithelium morphology (HP:0012253)2.59277004
41Abnormal respiratory motile cilium morphology (HP:0005938)2.59277004
42Small intestinal stenosis (HP:0012848)2.58214328
43Duodenal stenosis (HP:0100867)2.58214328
44Abnormality of glycolysis (HP:0004366)2.54719990
45Decreased activity of mitochondrial respiratory chain (HP:0008972)2.52759218
46Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.52759218
47Meckel diverticulum (HP:0002245)2.52083424
48Abnormality of the ileum (HP:0001549)2.51005775
49Increased muscle lipid content (HP:0009058)2.50194785
50Neoplasm of the oral cavity (HP:0100649)2.47755603
51Duplicated collecting system (HP:0000081)2.47741727
52Small hand (HP:0200055)2.44483938
53Supernumerary spleens (HP:0009799)2.41720577
54Abnormality of the labia minora (HP:0012880)2.41523591
55Abnormality of the preputium (HP:0100587)2.39306837
56Abnormality of chromosome stability (HP:0003220)2.38096549
57Annular pancreas (HP:0001734)2.37749819
58Brushfield spots (HP:0001088)2.37138037
59Abnormal respiratory motile cilium physiology (HP:0012261)2.35839023
60Ependymoma (HP:0002888)2.35266593
61Abnormal mitochondria in muscle tissue (HP:0008316)2.32627843
62Epileptic encephalopathy (HP:0200134)2.32083104
63Abnormality of DNA repair (HP:0003254)2.30917301
64CNS demyelination (HP:0007305)2.30742902
65Prolonged partial thromboplastin time (HP:0003645)2.29175576
66Astrocytoma (HP:0009592)2.28997331
67Abnormality of the astrocytes (HP:0100707)2.28997331
68Ectopic kidney (HP:0000086)2.28505965
69Nephronophthisis (HP:0000090)2.27017378
70Focal motor seizures (HP:0011153)2.26176722
71Cerebral edema (HP:0002181)2.25523029
72Acute encephalopathy (HP:0006846)2.25512710
73Autoimmune hemolytic anemia (HP:0001890)2.25349616
74Nephroblastoma (Wilms tumor) (HP:0002667)2.24348306
75Abnormality of the renal collecting system (HP:0004742)2.23259300
76Degeneration of anterior horn cells (HP:0002398)2.18432563
77Abnormality of the anterior horn cell (HP:0006802)2.18432563
78Pancytopenia (HP:0001876)2.17524269
79Colon cancer (HP:0003003)2.16934269
80Ketoacidosis (HP:0001993)2.16576824
81Gout (HP:0001997)2.14974852
82Obsessive-compulsive behavior (HP:0000722)2.14436628
83Molar tooth sign on MRI (HP:0002419)2.14289751
84Abnormality of midbrain morphology (HP:0002418)2.14289751
85Lipid accumulation in hepatocytes (HP:0006561)2.13925738
86Embryonal renal neoplasm (HP:0011794)2.13255803
87Acute hepatic failure (HP:0006554)2.13144871
88Combined immunodeficiency (HP:0005387)2.12599670
89Facial cleft (HP:0002006)2.11868489
90Myelodysplasia (HP:0002863)2.11766828
91Abnormality of the renal cortex (HP:0011035)2.11623729
92Glioma (HP:0009733)2.11527826
93Abnormal ciliary motility (HP:0012262)2.11401817
94Exercise intolerance (HP:0003546)2.10025077
95Selective tooth agenesis (HP:0001592)2.09789920
96Medial flaring of the eyebrow (HP:0010747)2.08457265
97Abnormality of the duodenum (HP:0002246)2.07989024
98Progressive muscle weakness (HP:0003323)2.07913508
99Abnormality of dicarboxylic acid metabolism (HP:0010995)2.07908083
100Dicarboxylic aciduria (HP:0003215)2.07908083
101Papillary thyroid carcinoma (HP:0002895)2.07110149
102Mitochondrial inheritance (HP:0001427)2.06995293
103Granulocytopenia (HP:0001913)2.06777481
104Palpitations (HP:0001962)2.05683663
105Albinism (HP:0001022)2.05088296
106Hypoglycemic coma (HP:0001325)2.04194077
107Sloping forehead (HP:0000340)2.03724052
108Pancreatic fibrosis (HP:0100732)2.03616203
109B lymphocytopenia (HP:0010976)2.02814825
110Panhypogammaglobulinemia (HP:0003139)2.02751015
111Patellar aplasia (HP:0006443)2.01116018
112Hypoplasia of the pons (HP:0012110)1.99546941
113Abnormality of fatty-acid metabolism (HP:0004359)1.98694911
114Gait imbalance (HP:0002141)1.98614400
115Premature ovarian failure (HP:0008209)1.98137104
116Ketosis (HP:0001946)1.95879145
117Abnormality of T cell physiology (HP:0011840)1.95032434
118Absent frontal sinuses (HP:0002688)1.94828585
119Increased hepatocellular lipid droplets (HP:0006565)1.94129503
120Multiple enchondromatosis (HP:0005701)1.94030772
121Metabolic acidosis (HP:0001942)1.92515923
122Postaxial foot polydactyly (HP:0001830)1.92414180
123Abnormality of methionine metabolism (HP:0010901)1.91862373
124Agnosia (HP:0010524)1.91774106
125Acute necrotizing encephalopathy (HP:0006965)1.90611620
126Neoplasm of the small intestine (HP:0100833)1.89305266
127Abnormality of the carotid arteries (HP:0005344)1.89049795
128Impulsivity (HP:0100710)1.88960642
129Bone marrow hypocellularity (HP:0005528)1.88949534
130Congenital primary aphakia (HP:0007707)1.88626290
131Abnormality of the pons (HP:0007361)1.87325378
132Nephrogenic diabetes insipidus (HP:0009806)1.87067433
133Limb hypertonia (HP:0002509)1.85984488
134Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.85834830
135Hypoproteinemia (HP:0003075)1.85040083
136Progressive microcephaly (HP:0000253)1.84730496
137Secondary amenorrhea (HP:0000869)1.83833073
138Pheochromocytoma (HP:0002666)1.83221477
139Aplasia/Hypoplasia of the patella (HP:0006498)1.82929510
140Epiphyseal stippling (HP:0010655)1.81728127
141Respiratory failure (HP:0002878)1.81224717
142True hermaphroditism (HP:0010459)1.81182114
143Right ventricular cardiomyopathy (HP:0011663)1.81024991
144Basal cell carcinoma (HP:0002671)1.80146326
145Tented upper lip vermilion (HP:0010804)1.79914889
146Abnormality of the lower motor neuron (HP:0002366)1.79124998
147Neuroendocrine neoplasm (HP:0100634)1.78442781
148Aplasia/Hypoplasia of the sternum (HP:0006714)1.77207863
149Tubulointerstitial nephritis (HP:0001970)1.76851030
150Acute myeloid leukemia (HP:0004808)1.76502273
151Tinnitus (HP:0000360)1.75455496
152Fair hair (HP:0002286)1.74296114
153Chronic bronchitis (HP:0004469)1.74021129
154Anophthalmia (HP:0000528)1.73570134
155Narrow forehead (HP:0000341)1.73158011
156Abnormality of cells of the erythroid lineage (HP:0012130)1.72739051
157Metaphyseal dysplasia (HP:0100255)1.72081792
158Supernumerary bones of the axial skeleton (HP:0009144)1.71023669
159Cleft eyelid (HP:0000625)1.70976042
160Preaxial hand polydactyly (HP:0001177)1.70847544
161Clubbing of toes (HP:0100760)1.70221824
162Ventricular tachycardia (HP:0004756)1.70192271
163Lethargy (HP:0001254)1.70037452
164Eosinophilia (HP:0001880)1.69904815
165Lower limb hyperreflexia (HP:0002395)1.69868978
166Gonadotropin excess (HP:0000837)1.69760456
167Abnormality of T cells (HP:0002843)1.67953494
168Delayed gross motor development (HP:0002194)1.66502843
169Aganglionic megacolon (HP:0002251)1.66353468
170Abnormality of the renal medulla (HP:0100957)1.66049771
171Gaze-evoked nystagmus (HP:0000640)1.64723018
172Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.64281199
173Optic nerve hypoplasia (HP:0000609)1.63938899
174Abnormal number of incisors (HP:0011064)1.62909484
175Rhinitis (HP:0012384)1.62333965
176Shawl scrotum (HP:0000049)1.61630069
177Weak cry (HP:0001612)1.61320451
178Abnormality of alanine metabolism (HP:0010916)1.61042930
179Hyperalaninemia (HP:0003348)1.61042930
180Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.61042930
181Absent thumb (HP:0009777)1.60746247
18211 pairs of ribs (HP:0000878)1.59953893
183Postaxial hand polydactyly (HP:0001162)1.58831027
184Aplastic anemia (HP:0001915)1.58827228
185Poor coordination (HP:0002370)1.58775602

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC73.73069973
2TIE13.55750614
3CASK3.18941110
4PDK32.94845324
5PDK42.94845324
6SCYL22.85961004
7EIF2AK32.69603980
8BUB12.66609577
9BCKDK2.42379688
10TSSK62.33190043
11AKT32.32810831
12CCNB12.31730089
13TAOK32.28213954
14MAP4K22.16132020
15MST42.10278416
16TNIK2.09552160
17TEC2.09049740
18NTRK32.06735650
19NME22.00471987
20TTK1.98557521
21NEK21.96198385
22NUAK11.88607915
23BMPR1B1.86926159
24BRD41.85063258
25WEE11.83282724
26PLK41.78638531
27MAPK131.78495704
28OBSCN1.78374742
29ATR1.78088402
30PBK1.77376061
31EPHA41.76722502
32MAP2K71.75814047
33PIM21.71233764
34PLK31.70280206
35SRPK11.68917267
36ACVR1B1.63785533
37TXK1.59806432
38PRPF4B1.59632938
39ZAK1.59027327
40MKNK11.56736945
41FES1.56055194
42MARK11.52050777
43PRKD31.51811327
44MAP3K41.47658352
45YES11.45746241
46PLK11.43911941
47CHEK21.42410176
48ITK1.37745032
49DAPK11.37541141
50PLK21.34251523
51BRSK21.32014502
52PDK21.32007337
53SGK21.29493960
54MKNK21.29079511
55BRSK11.27223885
56PASK1.26523992
57GRK11.26410569
58EPHA31.24024760
59VRK11.22974484
60DYRK1A1.16853717
61ERBB31.16416927
62CHEK11.13615982
63FLT31.09774756
64SIK31.09389796
65UHMK11.08417977
66TGFBR11.06743523
67SGK31.04635787
68LATS11.01652621
69NTRK21.00124706
70BRAF0.99657231
71STK160.99376014
72MAP3K140.98210203
73DYRK30.98166076
74CDK120.97555527
75SIK20.95567762
76EEF2K0.93308309
77EIF2AK10.90473198
78PIM10.90138041
79KDR0.90024648
80RAF10.85515797
81KIT0.83932750
82ATM0.83917055
83PRKAA20.83083541
84CDK70.82683326
85MINK10.82257421
86AURKB0.80867964
87RPS6KB10.79551035
88GRK60.79537992
89MAP3K130.79481197
90CDK20.79455172
91NEK10.79288326
92CDK10.78441713
93MAP2K40.76506590
94NEK90.76294608
95MAP2K60.76283049
96MAP3K120.74797638
97RPS6KA50.72871071
98MAP3K70.72657083
99CDK30.71520081
100PNCK0.71478549
101CAMKK20.69647436
102TESK20.69256294
103NLK0.68043846
104STK390.68015548
105RPS6KA40.67785792
106TRIM280.65584834
107SGK2230.64765644
108SGK4940.64765644
109EIF2AK20.64566952
110MAPK110.63844480
111MAP4K10.61488999
112CDK80.59307525
113BMPR20.58917254
114MAP3K60.57553118
115CDK190.57445352
116CDK40.56858492
117AURKA0.56631885
118PRKCG0.56286042
119MAPKAPK50.55827646
120RPS6KB20.55564570
121WNK30.54519260
122TRPM70.53368130
123PRKDC0.53053468
124BTK0.51705291
125STK380.51465554
126NEK60.51146460
127FER0.50537082
128CSNK1A1L0.49817010
129CSNK1G10.49422139
130GSK3B0.49009938
131DYRK20.48884474
132LCK0.48683695
133ADRBK20.48099320
134AKT20.47658862
135MAPK140.47223020
136MAPK80.47150260
137ALK0.46945091
138PRKCQ0.46627852
139ICK0.46220055
140CDK60.45265622
141MAP3K50.45197163
142NME10.44075654
143CDK50.43409547
144IKBKB0.42650119
145CSNK2A20.40455667
146DYRK1B0.38855786
147TAOK20.38184646
148MAPK100.37833691
149CSNK2A10.37291538
150SGK10.36917119
151CDK180.36663305
152TLK10.36502664
153PINK10.36399797
154CLK10.33755934
155CDK150.30714806
156CSNK1G30.29888913
157CSNK1E0.28020584
158CSNK1G20.27557646

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030303.94393409
2Mismatch repair_Homo sapiens_hsa034303.86518854
3Base excision repair_Homo sapiens_hsa034103.01156777
4Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.89048659
5Fanconi anemia pathway_Homo sapiens_hsa034602.87872895
6Spliceosome_Homo sapiens_hsa030402.63713164
7Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.49362960
8Homologous recombination_Homo sapiens_hsa034402.47836643
9Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.42385104
10Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.40214131
11Nucleotide excision repair_Homo sapiens_hsa034202.32709879
12Cell cycle_Homo sapiens_hsa041102.29507717
13Non-homologous end-joining_Homo sapiens_hsa034502.28939767
14Propanoate metabolism_Homo sapiens_hsa006402.28092991
15Nicotine addiction_Homo sapiens_hsa050332.18875118
16RNA transport_Homo sapiens_hsa030132.17004955
17Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.16856279
18Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.01754622
19Pyrimidine metabolism_Homo sapiens_hsa002402.00790296
20Basal transcription factors_Homo sapiens_hsa030221.93622126
212-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.92312291
22Cysteine and methionine metabolism_Homo sapiens_hsa002701.87091346
23mRNA surveillance pathway_Homo sapiens_hsa030151.79851562
24Pyruvate metabolism_Homo sapiens_hsa006201.77303463
25RNA polymerase_Homo sapiens_hsa030201.77032846
26RNA degradation_Homo sapiens_hsa030181.75766079
27Fatty acid elongation_Homo sapiens_hsa000621.75246222
28Oocyte meiosis_Homo sapiens_hsa041141.67242876
29Carbon metabolism_Homo sapiens_hsa012001.64345874
30Ribosome_Homo sapiens_hsa030101.55157752
31Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.49136639
32Taste transduction_Homo sapiens_hsa047421.48961598
33One carbon pool by folate_Homo sapiens_hsa006701.47665116
34Biosynthesis of amino acids_Homo sapiens_hsa012301.45414157
35Peroxisome_Homo sapiens_hsa041461.45010088
36Synaptic vesicle cycle_Homo sapiens_hsa047211.43830166
37Fatty acid degradation_Homo sapiens_hsa000711.41217094
38Olfactory transduction_Homo sapiens_hsa047401.38924573
39Sulfur relay system_Homo sapiens_hsa041221.36042901
40Purine metabolism_Homo sapiens_hsa002301.35703624
41Circadian entrainment_Homo sapiens_hsa047131.32982547
42Fatty acid metabolism_Homo sapiens_hsa012121.32377156
43Glutamatergic synapse_Homo sapiens_hsa047241.32026225
44Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.27837033
45Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.26262242
46Morphine addiction_Homo sapiens_hsa050321.25994919
47Amphetamine addiction_Homo sapiens_hsa050311.22828074
48Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.21061697
49Phenylalanine metabolism_Homo sapiens_hsa003601.15970825
50Long-term potentiation_Homo sapiens_hsa047201.14485870
51Primary immunodeficiency_Homo sapiens_hsa053401.11315004
52Tryptophan metabolism_Homo sapiens_hsa003801.07600810
53Alcoholism_Homo sapiens_hsa050341.07113390
54Butanoate metabolism_Homo sapiens_hsa006501.06978345
55Selenocompound metabolism_Homo sapiens_hsa004501.06338020
56Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.02059766
57Glutathione metabolism_Homo sapiens_hsa004800.99483412
58Vitamin B6 metabolism_Homo sapiens_hsa007500.98827843
59Pentose phosphate pathway_Homo sapiens_hsa000300.98551755
60Oxidative phosphorylation_Homo sapiens_hsa001900.98108855
61Parkinsons disease_Homo sapiens_hsa050120.95788137
62Proteasome_Homo sapiens_hsa030500.92967075
63Phototransduction_Homo sapiens_hsa047440.90492215
64GABAergic synapse_Homo sapiens_hsa047270.89890111
65Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.89583437
66Huntingtons disease_Homo sapiens_hsa050160.89021195
67Dopaminergic synapse_Homo sapiens_hsa047280.88679064
68Lysine degradation_Homo sapiens_hsa003100.85547882
69p53 signaling pathway_Homo sapiens_hsa041150.82544730
70ABC transporters_Homo sapiens_hsa020100.82286796
71Arginine and proline metabolism_Homo sapiens_hsa003300.80845259
72Protein export_Homo sapiens_hsa030600.80597300
73Systemic lupus erythematosus_Homo sapiens_hsa053220.79769237
74Calcium signaling pathway_Homo sapiens_hsa040200.79653689
75Serotonergic synapse_Homo sapiens_hsa047260.79509987
76Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.78159147
77Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.77471822
78Hedgehog signaling pathway_Homo sapiens_hsa043400.76682597
79Arginine biosynthesis_Homo sapiens_hsa002200.76584503
80Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.76147481
81Pentose and glucuronate interconversions_Homo sapiens_hsa000400.76080348
82Metabolic pathways_Homo sapiens_hsa011000.75699121
83Tyrosine metabolism_Homo sapiens_hsa003500.74318458
84Phosphatidylinositol signaling system_Homo sapiens_hsa040700.73800041
85Insulin secretion_Homo sapiens_hsa049110.73274893
86beta-Alanine metabolism_Homo sapiens_hsa004100.72497439
87Collecting duct acid secretion_Homo sapiens_hsa049660.71997788
88Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.70778861
89Basal cell carcinoma_Homo sapiens_hsa052170.69874936
90Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.68615880
91Glycosaminoglycan degradation_Homo sapiens_hsa005310.67900428
92Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.67889159
93Circadian rhythm_Homo sapiens_hsa047100.66971869
94Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.66276645
95Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.65538868
96Folate biosynthesis_Homo sapiens_hsa007900.64079634
97Wnt signaling pathway_Homo sapiens_hsa043100.63595783
98Drug metabolism - other enzymes_Homo sapiens_hsa009830.63327255
99Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.62520435
100HTLV-I infection_Homo sapiens_hsa051660.60918094
101Renin-angiotensin system_Homo sapiens_hsa046140.60890604
102Long-term depression_Homo sapiens_hsa047300.60504269
103Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.59753245
104Epstein-Barr virus infection_Homo sapiens_hsa051690.59589365
105Sulfur metabolism_Homo sapiens_hsa009200.57195156
106Glucagon signaling pathway_Homo sapiens_hsa049220.56271657
107Chemical carcinogenesis_Homo sapiens_hsa052040.54752683
108Renin secretion_Homo sapiens_hsa049240.54684503
109Primary bile acid biosynthesis_Homo sapiens_hsa001200.54455625
110Viral carcinogenesis_Homo sapiens_hsa052030.53964612
111Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.53631917
112Herpes simplex infection_Homo sapiens_hsa051680.52291172
113Inositol phosphate metabolism_Homo sapiens_hsa005620.52284893
114Salivary secretion_Homo sapiens_hsa049700.52268087
115Cholinergic synapse_Homo sapiens_hsa047250.52133140
116Regulation of autophagy_Homo sapiens_hsa041400.51729836
117Colorectal cancer_Homo sapiens_hsa052100.51357771
118Oxytocin signaling pathway_Homo sapiens_hsa049210.51058596
119Axon guidance_Homo sapiens_hsa043600.48498516
120Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.47899897
121Cocaine addiction_Homo sapiens_hsa050300.47717488
122Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.47714577
123Non-small cell lung cancer_Homo sapiens_hsa052230.47599770
124Transcriptional misregulation in cancer_Homo sapiens_hsa052020.44626760
125Cyanoamino acid metabolism_Homo sapiens_hsa004600.44270963
126cAMP signaling pathway_Homo sapiens_hsa040240.43435434
127Thyroid hormone signaling pathway_Homo sapiens_hsa049190.42315385
128ErbB signaling pathway_Homo sapiens_hsa040120.41877785
129Thyroid cancer_Homo sapiens_hsa052160.41127870
130Retinol metabolism_Homo sapiens_hsa008300.41019338
131Fructose and mannose metabolism_Homo sapiens_hsa000510.39611001
132Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.39443335
133Hippo signaling pathway_Homo sapiens_hsa043900.39047684
134Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.38470272
135Linoleic acid metabolism_Homo sapiens_hsa005910.37001791
136Vibrio cholerae infection_Homo sapiens_hsa051100.36606062
137Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.36478738
138cGMP-PKG signaling pathway_Homo sapiens_hsa040220.36183335
139Alzheimers disease_Homo sapiens_hsa050100.35418441
140Caffeine metabolism_Homo sapiens_hsa002320.35096969
141Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.33682309
142Aldosterone synthesis and secretion_Homo sapiens_hsa049250.33519885
143Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.32813354
144Histidine metabolism_Homo sapiens_hsa003400.32738423
145Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.32536664
146MAPK signaling pathway_Homo sapiens_hsa040100.32453463
147N-Glycan biosynthesis_Homo sapiens_hsa005100.31260961
148Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.30643173
149Gap junction_Homo sapiens_hsa045400.30171351
150Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.29546011
151Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.29128536
152MicroRNAs in cancer_Homo sapiens_hsa052060.29107844
153Melanogenesis_Homo sapiens_hsa049160.28793648
154Vitamin digestion and absorption_Homo sapiens_hsa049770.28768705
155Fatty acid biosynthesis_Homo sapiens_hsa000610.28697776
156Steroid hormone biosynthesis_Homo sapiens_hsa001400.28158557
157Gastric acid secretion_Homo sapiens_hsa049710.27605647
158Choline metabolism in cancer_Homo sapiens_hsa052310.26629766
159Glioma_Homo sapiens_hsa052140.24257120
160Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.23915022
161Endometrial cancer_Homo sapiens_hsa052130.23644772
162Estrogen signaling pathway_Homo sapiens_hsa049150.22951081
163Cardiac muscle contraction_Homo sapiens_hsa042600.22490564
164Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.21045624
165SNARE interactions in vesicular transport_Homo sapiens_hsa041300.20764276
166Sphingolipid metabolism_Homo sapiens_hsa006000.20699566
167Ras signaling pathway_Homo sapiens_hsa040140.20368081

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