INTS12

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: INTS12 is a subunit of the Integrator complex, which associates with the C-terminal domain of RNA polymerase II large subunit (POLR2A; MIM 180660) and mediates 3-prime end processing of small nuclear RNAs U1 (RNU1; MIM 180680) and U2 (RNU2; MIM 180690) (Baillat et al., 2005 [PubMed 16239144]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cullin deneddylation (GO:0010388)5.42262640
2protein deneddylation (GO:0000338)4.95249374
3mitotic metaphase plate congression (GO:0007080)4.38396056
4DNA double-strand break processing (GO:0000729)4.27213893
5protein neddylation (GO:0045116)4.16611778
6mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.98266770
7establishment of protein localization to mitochondrial membrane (GO:0090151)3.97692768
8DNA replication checkpoint (GO:0000076)3.92980319
9regulation of cellular amino acid metabolic process (GO:0006521)3.92648604
10negative regulation of ligase activity (GO:0051352)3.86341825
11negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.86341825
12metaphase plate congression (GO:0051310)3.83827200
13DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.79356258
14positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.79275309
15protein localization to kinetochore (GO:0034501)3.78303483
16kinetochore organization (GO:0051383)3.70922010
17signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.69611358
18signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.69611358
19signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.69611358
20signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.68445151
21intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.68445151
22mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.67023196
23positive regulation of ligase activity (GO:0051351)3.66521837
24protein-cofactor linkage (GO:0018065)3.66297127
25ribonucleoprotein complex disassembly (GO:0032988)3.65432622
26establishment of chromosome localization (GO:0051303)3.65223101
27synapsis (GO:0007129)3.64766984
28organelle disassembly (GO:1903008)3.62375456
29maturation of SSU-rRNA (GO:0030490)3.61183963
30respiratory chain complex IV assembly (GO:0008535)3.57633472
31CENP-A containing nucleosome assembly (GO:0034080)3.54651253
32signal transduction involved in cell cycle checkpoint (GO:0072395)3.51373387
33signal transduction involved in DNA integrity checkpoint (GO:0072401)3.48439110
34signal transduction involved in DNA damage checkpoint (GO:0072422)3.48439110
35nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.48387301
36protein localization to chromosome, centromeric region (GO:0071459)3.48372319
37attachment of spindle microtubules to kinetochore (GO:0008608)3.46155178
38DNA strand elongation involved in DNA replication (GO:0006271)3.44740762
39ribosomal small subunit assembly (GO:0000028)3.44104053
40DNA catabolic process, exonucleolytic (GO:0000738)3.43295277
41mitotic nuclear envelope disassembly (GO:0007077)3.42772886
42exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.42150714
43kinetochore assembly (GO:0051382)3.42098636
44chromatin remodeling at centromere (GO:0031055)3.41853626
45protein complex biogenesis (GO:0070271)3.39983321
46ATP synthesis coupled proton transport (GO:0015986)3.37289699
47energy coupled proton transport, down electrochemical gradient (GO:0015985)3.37289699
48DNA damage response, detection of DNA damage (GO:0042769)3.33454292
49regulation of ubiquitin-protein transferase activity (GO:0051438)3.32897003
50purine nucleobase biosynthetic process (GO:0009113)3.32076232
51formation of translation preinitiation complex (GO:0001731)3.27206077
52meiotic chromosome segregation (GO:0045132)3.26599509
53DNA strand elongation (GO:0022616)3.26028838
54neutrophil activation involved in immune response (GO:0002283)3.25524954
55telomere maintenance via semi-conservative replication (GO:0032201)3.24666664
56regulation of ligase activity (GO:0051340)3.24217804
57regulation of spindle organization (GO:0090224)3.22407915
58telomere maintenance via recombination (GO:0000722)3.22272280
59L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.20471767
60mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.18733592
61mitochondrial respiratory chain complex I assembly (GO:0032981)3.18733592
62NADH dehydrogenase complex assembly (GO:0010257)3.18733592
63mitochondrial respiratory chain complex assembly (GO:0033108)3.17918507
64cytochrome complex assembly (GO:0017004)3.17368537
65mitotic recombination (GO:0006312)3.16762657
66nuclear envelope disassembly (GO:0051081)3.15767889
67membrane disassembly (GO:0030397)3.15767889
68mitotic chromosome condensation (GO:0007076)3.12983794
69nuclear pore organization (GO:0006999)3.11646075
70chaperone-mediated protein transport (GO:0072321)3.10679938
71rRNA modification (GO:0000154)3.10100455
72DNA replication-independent nucleosome organization (GO:0034724)3.09951304
73DNA replication-independent nucleosome assembly (GO:0006336)3.09951304
74respiratory electron transport chain (GO:0022904)3.09188636
75regulation of meiosis I (GO:0060631)3.07203932
76proteasome assembly (GO:0043248)3.04175367
77establishment of viral latency (GO:0019043)3.03616318
78platelet dense granule organization (GO:0060155)3.02361491
79piRNA metabolic process (GO:0034587)3.02164980
80electron transport chain (GO:0022900)3.01767223
81protein K11-linked ubiquitination (GO:0070979)3.00106145
82ribosome assembly (GO:0042255)2.99764854
83centriole replication (GO:0007099)2.99495393
84replication fork processing (GO:0031297)2.99311461
85DNA damage response, signal transduction by p53 class mediator (GO:0030330)2.98500346
86regulation of mitochondrial translation (GO:0070129)2.97595099
87metallo-sulfur cluster assembly (GO:0031163)2.97333051
88iron-sulfur cluster assembly (GO:0016226)2.97333051
89nucleobase biosynthetic process (GO:0046112)2.96198299
90resolution of meiotic recombination intermediates (GO:0000712)2.95569242
91DNA replication initiation (GO:0006270)2.94510453
92mannosylation (GO:0097502)2.94357204
93DNA demethylation (GO:0080111)2.93416249
94regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.92204837
95regulation of cilium movement (GO:0003352)2.91937930
96amino acid activation (GO:0043038)2.90902164
97tRNA aminoacylation (GO:0043039)2.90902164
98tRNA aminoacylation for protein translation (GO:0006418)2.90708067
99negative regulation of protein ubiquitination (GO:0031397)2.90595863
100meiosis I (GO:0007127)2.90183142
101anterograde synaptic vesicle transport (GO:0048490)2.88954976
102regulation of double-strand break repair via homologous recombination (GO:0010569)2.87426963
103DNA unwinding involved in DNA replication (GO:0006268)2.87318977
104histone exchange (GO:0043486)2.86707197
105positive regulation of chromosome segregation (GO:0051984)2.86089018
106male meiosis I (GO:0007141)2.85811014
107nuclear pore complex assembly (GO:0051292)2.83930618
108histone H2A acetylation (GO:0043968)2.82754158
109lactate metabolic process (GO:0006089)2.82693804
110pseudouridine synthesis (GO:0001522)2.80866481
111amino acid salvage (GO:0043102)2.79460691
112L-methionine salvage (GO:0071267)2.79460691
113L-methionine biosynthetic process (GO:0071265)2.79460691
114IMP biosynthetic process (GO:0006188)2.78973463
115spliceosomal snRNP assembly (GO:0000387)2.77149472
116immunoglobulin mediated immune response (GO:0016064)2.76345738
117regulation of cellular amine metabolic process (GO:0033238)2.75672874
118mitotic sister chromatid segregation (GO:0000070)2.75329062
119positive regulation of cell cycle arrest (GO:0071158)2.74449719
120rRNA methylation (GO:0031167)2.74042100
121preassembly of GPI anchor in ER membrane (GO:0016254)2.73713595
122protein localization to mitochondrion (GO:0070585)2.72273374
123anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.70603463
124protein targeting to mitochondrion (GO:0006626)2.69857248
125nucleotide-excision repair, DNA gap filling (GO:0006297)2.69160836
126B cell mediated immunity (GO:0019724)2.68653052
127transcription elongation from RNA polymerase I promoter (GO:0006362)2.68650281
128maturation of 5.8S rRNA (GO:0000460)2.68502417
129response to peptidoglycan (GO:0032494)2.67729707
130spindle checkpoint (GO:0031577)2.66223049
131telomere maintenance via telomere lengthening (GO:0010833)2.66049268
1327-methylguanosine mRNA capping (GO:0006370)2.64801435
1337-methylguanosine RNA capping (GO:0009452)2.64210071
134RNA capping (GO:0036260)2.64210071
135DNA deamination (GO:0045006)2.63790231
136regulation of mitotic spindle organization (GO:0060236)2.62813970
137regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.61945273
138ribosome biogenesis (GO:0042254)2.61681690
139modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.61467639
140positive regulation by organism of defense response of other organism involved in symbiotic interact2.61467639
141modulation by symbiont of host immune response (GO:0052553)2.61467639
142positive regulation by symbiont of host defense response (GO:0052509)2.61467639
143modulation by symbiont of host defense response (GO:0052031)2.61467639
144modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.61467639
145negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.60555163
146positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.60014306
147antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.57300703
148positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.56403851
149positive regulation of mitotic sister chromatid separation (GO:1901970)2.56403851
150positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.56403851
151regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.53191815
152ribosomal large subunit biogenesis (GO:0042273)2.53169124
153chromosome segregation (GO:0007059)2.52068663
154regulation of mitotic metaphase/anaphase transition (GO:0030071)2.51815305
155protein K6-linked ubiquitination (GO:0085020)2.51687913
156antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.51313560
157regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.49934944
158regulation of mitotic spindle checkpoint (GO:1903504)2.49934944
159regulation of translation in response to stress (GO:0043555)2.49710365
160rRNA processing (GO:0006364)2.49384680
161G1/S transition of mitotic cell cycle (GO:0000082)2.49090386
162cell cycle G1/S phase transition (GO:0044843)2.49090386
163transcription elongation from RNA polymerase III promoter (GO:0006385)2.48980324
164termination of RNA polymerase III transcription (GO:0006386)2.48980324
165protein localization to chromosome (GO:0034502)2.48616901
166ribonucleoprotein complex biogenesis (GO:0022613)2.47410876
167regulation of centrosome cycle (GO:0046605)2.46164970
168nuclear envelope organization (GO:0006998)2.46028987
169IMP metabolic process (GO:0046040)2.45967463
170regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.45877298
171folic acid-containing compound biosynthetic process (GO:0009396)2.44727973
172histone mRNA metabolic process (GO:0008334)2.44120855
173sister chromatid segregation (GO:0000819)2.42876775
174negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.42847013
175mitotic spindle checkpoint (GO:0071174)2.42075849
176transcription-coupled nucleotide-excision repair (GO:0006283)2.41370144
177negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.40739900
178negative regulation of sister chromatid segregation (GO:0033046)2.40739900
179negative regulation of mitotic sister chromatid separation (GO:2000816)2.40739900
180negative regulation of mitotic sister chromatid segregation (GO:0033048)2.40739900
181regulation of chromosome segregation (GO:0051983)2.39496150

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.41371668
2FOXM1_23109430_ChIP-Seq_U2OS_Human3.94480422
3E2F4_17652178_ChIP-ChIP_JURKAT_Human3.46315949
4MYC_18555785_ChIP-Seq_MESCs_Mouse3.38606925
5KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.17423767
6EGR1_19374776_ChIP-ChIP_THP-1_Human3.10984513
7GABP_17652178_ChIP-ChIP_JURKAT_Human3.03888722
8* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.02675870
9EST1_17652178_ChIP-ChIP_JURKAT_Human3.01079332
10* IRF8_21731497_ChIP-ChIP_J774_Mouse2.78940755
11EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.72461955
12ZNF274_21170338_ChIP-Seq_K562_Hela2.66180169
13CREB1_15753290_ChIP-ChIP_HEK293T_Human2.61075448
14JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.50457649
15E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.41661799
16* ETS1_20019798_ChIP-Seq_JURKAT_Human2.41026951
17MYC_19030024_ChIP-ChIP_MESCs_Mouse2.36057113
18TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.34246792
19VDR_22108803_ChIP-Seq_LS180_Human2.32614549
20* VDR_23849224_ChIP-Seq_CD4+_Human2.28776482
21MYC_19079543_ChIP-ChIP_MESCs_Mouse2.28059529
22SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.19371224
23* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.19133154
24NELFA_20434984_ChIP-Seq_ESCs_Mouse2.15131542
25CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.13401559
26ELK1_19687146_ChIP-ChIP_HELA_Human2.11079372
27IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.09379819
28MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.06590774
29POU3F2_20337985_ChIP-ChIP_501MEL_Human2.03615881
30AR_21909140_ChIP-Seq_LNCAP_Human2.03530597
31EWS_26573619_Chip-Seq_HEK293_Human2.00102531
32ELF1_17652178_ChIP-ChIP_JURKAT_Human1.95123333
33FUS_26573619_Chip-Seq_HEK293_Human1.92151411
34E2F1_21310950_ChIP-Seq_MCF-7_Human1.91796879
35SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.88606837
36PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.88061397
37BP1_19119308_ChIP-ChIP_Hs578T_Human1.83145949
38IRF8_22096565_ChIP-ChIP_GC-B_Human1.82973361
39XRN2_22483619_ChIP-Seq_HELA_Human1.81896164
40HOXB4_20404135_ChIP-ChIP_EML_Mouse1.81883084
41HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.81272564
42* FOXP3_21729870_ChIP-Seq_TREG_Human1.81227223
43E2F1_18555785_ChIP-Seq_MESCs_Mouse1.78543207
44HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.77994901
45NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.75558439
46ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.72916898
47* DCP1A_22483619_ChIP-Seq_HELA_Human1.70108372
48MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.69682550
49* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.68958848
50FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.68755996
51KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.68559133
52NANOG_18555785_ChIP-Seq_MESCs_Mouse1.63981964
53* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.63584456
54SPI1_23547873_ChIP-Seq_NB4_Human1.62203725
55GABP_19822575_ChIP-Seq_HepG2_Human1.59871365
56MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.56735448
57* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.56124487
58IGF1R_20145208_ChIP-Seq_DFB_Human1.54751927
59* TTF2_22483619_ChIP-Seq_HELA_Human1.54386615
60* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.50772404
61MYB_21317192_ChIP-Seq_ERMYB_Mouse1.50007717
62* POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.49509063
63* MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.49280382
64GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.45962482
65NOTCH1_21737748_ChIP-Seq_TLL_Human1.43660038
66TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.43265492
67TP63_19390658_ChIP-ChIP_HaCaT_Human1.41695711
68ZFP57_27257070_Chip-Seq_ESCs_Mouse1.41317368
69SRF_21415370_ChIP-Seq_HL-1_Mouse1.39528383
70FLI1_27457419_Chip-Seq_LIVER_Mouse1.38450150
71CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.36717396
72YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.36525268
73P300_19829295_ChIP-Seq_ESCs_Human1.36363159
74ERG_20887958_ChIP-Seq_HPC-7_Mouse1.34376289
75* PADI4_21655091_ChIP-ChIP_MCF-7_Human1.33487587
76TFEB_21752829_ChIP-Seq_HELA_Human1.32869991
77TAF15_26573619_Chip-Seq_HEK293_Human1.31959697
78CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.29787414
79THAP11_20581084_ChIP-Seq_MESCs_Mouse1.29102154
80YY1_21170310_ChIP-Seq_MESCs_Mouse1.28560736
81* IRF8_27001747_Chip-Seq_BMDM_Mouse1.26180585
82STAT4_19710469_ChIP-ChIP_TH1__Mouse1.25307669
83CIITA_25753668_ChIP-Seq_RAJI_Human1.21685583
84GBX2_23144817_ChIP-Seq_PC3_Human1.16790618
85NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.16670126
86PCGF2_27294783_Chip-Seq_ESCs_Mouse1.16399815
87* TP53_22573176_ChIP-Seq_HFKS_Human1.16310214
88EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.14369381
89CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.13543755
90MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.12652606
91KDM5A_27292631_Chip-Seq_BREAST_Human1.12561068
92* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.10641372
93CTBP2_25329375_ChIP-Seq_LNCAP_Human1.10541656
94RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.10290273
95ELK1_22589737_ChIP-Seq_MCF10A_Human1.09752772
96ZFX_18555785_ChIP-Seq_MESCs_Mouse1.08594487
97HTT_18923047_ChIP-ChIP_STHdh_Human1.08037141
98PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.07225185
99MYC_22102868_ChIP-Seq_BL_Human1.06738614
100CBP_20019798_ChIP-Seq_JUKART_Human1.06500487
101IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.06500487
102ER_23166858_ChIP-Seq_MCF-7_Human1.06105572
103POU5F1_16153702_ChIP-ChIP_HESCs_Human1.04527419
104E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.02724603
105ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.02526120
106MYB_26560356_Chip-Seq_TH2_Human0.99846930
107CTBP1_25329375_ChIP-Seq_LNCAP_Human0.99727954
108SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.97205678
109SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.95552702
110GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.95214269
111* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.94710027
112PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.93564559
113POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.92169749
114GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.91493778
115BRD4_27068464_Chip-Seq_AML-cells_Mouse0.90679538
116HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.90461931
117ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.90412596
118* KLF4_18555785_ChIP-Seq_MESCs_Mouse0.89756385
119IRF1_19129219_ChIP-ChIP_H3396_Human0.89618868
120EZH2_27294783_Chip-Seq_NPCs_Mouse0.88467834
121MYB_26560356_Chip-Seq_TH1_Human0.88223504
122SALL4_22934838_ChIP-ChIP_CD34+_Human0.88093435
123NANOG_19829295_ChIP-Seq_ESCs_Human0.87748360
124SOX2_19829295_ChIP-Seq_ESCs_Human0.87748360
125FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.87326044
126STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.86422804
127STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.86359570
128BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.86140367
129AR_20517297_ChIP-Seq_VCAP_Human0.85775710
130MYC_18940864_ChIP-ChIP_HL60_Human0.85728700
131AUTS2_25519132_ChIP-Seq_293T-REX_Human0.85306040
132CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.84616046
133STAT3_1855785_ChIP-Seq_MESCs_Mouse0.81949180
134CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.80358716
135POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.79423891
136SALL1_21062744_ChIP-ChIP_HESCs_Human0.78426149
137GATA2_22383799_ChIP-Seq_G1ME_Mouse0.78067231
138CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.78061894
139RBPJ_22232070_ChIP-Seq_NCS_Mouse0.77400114
140IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.77322439

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.76638229
2MP0002102_abnormal_ear_morphology3.65460314
3MP0008057_abnormal_DNA_replication3.54381671
4MP0010094_abnormal_chromosome_stability3.45380157
5MP0004957_abnormal_blastocyst_morpholog3.34228042
6MP0003111_abnormal_nucleus_morphology3.18422387
7MP0002837_dystrophic_cardiac_calcinosis3.17007756
8MP0003077_abnormal_cell_cycle3.14208310
9MP0001529_abnormal_vocalization2.88096944
10MP0001835_abnormal_antigen_presentation2.54758381
11MP0008058_abnormal_DNA_repair2.49308418
12MP0009785_altered_susceptibility_to2.39432052
13MP0003436_decreased_susceptibility_to2.37237407
14MP0008789_abnormal_olfactory_epithelium2.31477721
15MP0008007_abnormal_cellular_replicative2.23498375
16MP0001188_hyperpigmentation2.17867621
17MP0003718_maternal_effect2.16115680
18MP0001764_abnormal_homeostasis2.15398634
19MP0008995_early_reproductive_senescence2.08220113
20MP0003806_abnormal_nucleotide_metabolis2.00040152
21MP0006035_abnormal_mitochondrial_morpho1.99008160
22MP0005671_abnormal_response_to1.97309207
23MP0003195_calcinosis1.96563947
24MP0002148_abnormal_hypersensitivity_rea1.92246619
25MP0010307_abnormal_tumor_latency1.90310894
26MP0009333_abnormal_splenocyte_physiolog1.87722659
27MP0005000_abnormal_immune_tolerance1.86803341
28MP0002396_abnormal_hematopoietic_system1.86047285
29MP0002419_abnormal_innate_immunity1.85261170
30MP0005084_abnormal_gallbladder_morpholo1.83514095
31MP0006036_abnormal_mitochondrial_physio1.83012879
32MP0008932_abnormal_embryonic_tissue1.80382738
33MP0000350_abnormal_cell_proliferation1.77338663
34MP0002452_abnormal_antigen_presenting1.76156882
35MP0008877_abnormal_DNA_methylation1.75970930
36MP0004808_abnormal_hematopoietic_stem1.72348558
37MP0001800_abnormal_humoral_immune1.72265440
38MP0003123_paternal_imprinting1.71698818
39MP0006292_abnormal_olfactory_placode1.69911104
40MP0005367_renal/urinary_system_phenotyp1.69659632
41MP0000516_abnormal_urinary_system1.69659632
42MP0005025_abnormal_response_to1.68936258
43MP0004215_abnormal_myocardial_fiber1.67816424
44MP0005394_taste/olfaction_phenotype1.67568614
45MP0005499_abnormal_olfactory_system1.67568614
46MP0000490_abnormal_crypts_of1.66272987
47MP0006072_abnormal_retinal_apoptosis1.66228108
48MP0000685_abnormal_immune_system1.65418260
49MP0002723_abnormal_immune_serum1.62933800
50MP0005253_abnormal_eye_physiology1.60952152
51MP0003011_delayed_dark_adaptation1.60094792
52MP0001819_abnormal_immune_cell1.58997623
53MP0002420_abnormal_adaptive_immunity1.57359378
54MP0002398_abnormal_bone_marrow1.56609570
55MP0002282_abnormal_trachea_morphology1.55036511
56MP0002163_abnormal_gland_morphology1.53826216
57MP0001730_embryonic_growth_arrest1.52546154
58MP0001984_abnormal_olfaction1.52375071
59MP0000372_irregular_coat_pigmentation1.51692344
60MP0002736_abnormal_nociception_after1.48850697
61MP0001853_heart_inflammation1.47231668
62MP0001790_abnormal_immune_system1.46180556
63MP0005387_immune_system_phenotype1.46180556
64MP0005397_hematopoietic_system_phenotyp1.44125047
65MP0001545_abnormal_hematopoietic_system1.44125047
66MP0002138_abnormal_hepatobiliary_system1.43607370
67MP0000689_abnormal_spleen_morphology1.43282081
68MP0002405_respiratory_system_inflammati1.40775500
69MP0002234_abnormal_pharynx_morphology1.39420341
70MP0000716_abnormal_immune_system1.39264737
71MP0002722_abnormal_immune_system1.38797381
72MP0010352_gastrointestinal_tract_polyps1.36361767
73MP0003786_premature_aging1.36115151
74MP0000749_muscle_degeneration1.35234712
75MP0003136_yellow_coat_color1.34885164
76MP0003724_increased_susceptibility_to1.34461455
77MP0003448_altered_tumor_morphology1.33109222
78MP0002928_abnormal_bile_duct1.31720618
79MP0002751_abnormal_autonomic_nervous1.29546332
80MP0000313_abnormal_cell_death1.29431569
81MP0005551_abnormal_eye_electrophysiolog1.28408453
82MP0002429_abnormal_blood_cell1.27849831
83MP0002019_abnormal_tumor_incidence1.26854519
84MP0000858_altered_metastatic_potential1.25603916
85MP0003763_abnormal_thymus_physiology1.22325078
86MP0006082_CNS_inflammation1.20798665
87MP0002006_tumorigenesis1.19781018
88MP0004142_abnormal_muscle_tone1.18950532
89MP0001533_abnormal_skeleton_physiology1.16286210
90MP0000343_altered_response_to1.15530981
91MP0001845_abnormal_inflammatory_respons1.13898662
92MP0005076_abnormal_cell_differentiation1.13140403
93MP0003646_muscle_fatigue1.12554640
94MP0001697_abnormal_embryo_size1.12080830
95MP0003303_peritoneal_inflammation1.12051435
96MP0003186_abnormal_redox_activity1.11365440
97MP0001672_abnormal_embryogenesis/_devel1.10455517
98MP0005380_embryogenesis_phenotype1.10455517
99MP0010155_abnormal_intestine_physiology1.08805489
100MP0002233_abnormal_nose_morphology1.07940124
101MP0004145_abnormal_muscle_electrophysio1.07798780
102MP0000703_abnormal_thymus_morphology1.07059678
103MP0008775_abnormal_heart_ventricle1.06784921
104MP0003567_abnormal_fetal_cardiomyocyte1.06063794
105MP0005379_endocrine/exocrine_gland_phen1.06056692
106MP0002277_abnormal_respiratory_mucosa1.03286131
107MP0009046_muscle_twitch1.02091848
108MP0003880_abnormal_central_pattern1.01988748
109MP0002132_abnormal_respiratory_system1.00200206
110MP0000358_abnormal_cell_content/0.99824600
111MP0001119_abnormal_female_reproductive0.98994985
112MP0005408_hypopigmentation0.98213902
113MP0005410_abnormal_fertilization0.98179094
114MP0003950_abnormal_plasma_membrane0.96163498
115MP0003698_abnormal_male_reproductive0.96117279
116MP0003984_embryonic_growth_retardation0.95471608
117MP0002080_prenatal_lethality0.94030957
118MP0002088_abnormal_embryonic_growth/wei0.93281148
119MP0005464_abnormal_platelet_physiology0.90250040
120MP0005266_abnormal_metabolism0.89891264
121MP0002095_abnormal_skin_pigmentation0.89213117
122MP0002166_altered_tumor_susceptibility0.89032493
123MP0001485_abnormal_pinna_reflex0.89015743
124MP0002086_abnormal_extraembryonic_tissu0.88257118
125MP0006276_abnormal_autonomic_nervous0.87489416
126MP0009278_abnormal_bone_marrow0.87300368
127MP0002210_abnormal_sex_determination0.86840076
128MP0004947_skin_inflammation0.85317016
129MP0002085_abnormal_embryonic_tissue0.85315925
130MP0002090_abnormal_vision0.85262507
131MP0001293_anophthalmia0.85051864
132MP0005310_abnormal_salivary_gland0.84350137
133MP0005621_abnormal_cell_physiology0.84082605
134MP0000465_gastrointestinal_hemorrhage0.83421703
135MP0000569_abnormal_digit_pigmentation0.83316989
136MP0002127_abnormal_cardiovascular_syste0.82673143
137MP0001968_abnormal_touch/_nociception0.82662527
138MP0004084_abnormal_cardiac_muscle0.82136009
139MP0000647_abnormal_sebaceous_gland0.81951192
140MP0008260_abnormal_autophagy0.81532101
141MP0008469_abnormal_protein_level0.81037848
142MP0002933_joint_inflammation0.80728584
143MP0003890_abnormal_embryonic-extraembry0.80363517
144MP0003121_genomic_imprinting0.79593407
145MP0006054_spinal_hemorrhage0.79290451
146MP0001905_abnormal_dopamine_level0.78823775
147MP0005384_cellular_phenotype0.78485405
148MP0001986_abnormal_taste_sensitivity0.78327808
149MP0010386_abnormal_urinary_bladder0.76673242
150MP0002160_abnormal_reproductive_system0.76575023
151MP0002938_white_spotting0.76021870
152MP0000427_abnormal_hair_cycle0.74833363
153MP0005390_skeleton_phenotype0.74456017
154MP0005058_abnormal_lysosome_morphology0.72416267
155MP0002177_abnormal_outer_ear0.72246981
156MP0001929_abnormal_gametogenesis0.71773616
157MP0003828_pulmonary_edema0.70655982
158MP0001915_intracranial_hemorrhage0.70518378
159MP0004782_abnormal_surfactant_physiolog0.70440574
160MP0002272_abnormal_nervous_system0.70385276
161MP0005395_other_phenotype0.70156743
162MP0005389_reproductive_system_phenotype0.69838631
163MP0003937_abnormal_limbs/digits/tail_de0.69734387
164MP0005023_abnormal_wound_healing0.69732560
165MP0001145_abnormal_male_reproductive0.69352363
166MP0000653_abnormal_sex_gland0.69248837
167MP0005332_abnormal_amino_acid0.69220117
168MP0002084_abnormal_developmental_patter0.69151258
169MP0009697_abnormal_copulation0.68816387
170MP0000613_abnormal_salivary_gland0.67570769
171MP0002332_abnormal_exercise_endurance0.67045216
172MP0003787_abnormal_imprinting0.66848874
173MP0003315_abnormal_perineum_morphology0.66802611
174MP0003122_maternal_imprinting0.66533047
175MP0005376_homeostasis/metabolism_phenot0.64641746
176MP0000049_abnormal_middle_ear0.64053047
177MP0005391_vision/eye_phenotype0.63402732

Predicted human phenotypes

RankGene SetZ-score
1Recurrent abscess formation (HP:0002722)5.18236740
2Recurrent bacterial skin infections (HP:0005406)4.59631173
3Birth length less than 3rd percentile (HP:0003561)4.43565673
4Acute necrotizing encephalopathy (HP:0006965)4.35551907
5Abnormality of the anterior horn cell (HP:0006802)4.16726880
6Degeneration of anterior horn cells (HP:0002398)4.16726880
7Progressive macrocephaly (HP:0004481)3.92077539
8Abnormal mitochondria in muscle tissue (HP:0008316)3.91172914
9Increased CSF lactate (HP:0002490)3.89748636
10Acute encephalopathy (HP:0006846)3.87021413
11Mitochondrial inheritance (HP:0001427)3.82745993
12Eczematoid dermatitis (HP:0000976)3.76944619
13Hepatocellular necrosis (HP:0001404)3.57621417
14Hepatic necrosis (HP:0002605)3.48733255
15Chromsome breakage (HP:0040012)3.14193337
16Mediastinal lymphadenopathy (HP:0100721)3.06920856
17Agnosia (HP:0010524)3.06806173
18Breast hypoplasia (HP:0003187)3.06128028
19Thrombocytosis (HP:0001894)3.02771574
20Increased hepatocellular lipid droplets (HP:0006565)3.00411766
21Recurrent gram-negative bacterial infections (HP:0005420)2.98866805
22Obstructive lung disease (HP:0006536)2.97153985
23Chronic obstructive pulmonary disease (HP:0006510)2.97153985
24Cerebral edema (HP:0002181)2.91292814
25Abnormality of chromosome stability (HP:0003220)2.86563876
26Medial flaring of the eyebrow (HP:0010747)2.86429594
27Carpal bone hypoplasia (HP:0001498)2.84506263
28Increased serum lactate (HP:0002151)2.82340008
29Lipid accumulation in hepatocytes (HP:0006561)2.79895250
30Abnormality of macrophages (HP:0004311)2.75961918
31Aplasia/Hypoplasia of the patella (HP:0006498)2.75673403
32Pancreatic cysts (HP:0001737)2.75485095
333-Methylglutaconic aciduria (HP:0003535)2.71385718
34Chromosomal breakage induced by crosslinking agents (HP:0003221)2.69690955
35Abnormality of midbrain morphology (HP:0002418)2.68653078
36Molar tooth sign on MRI (HP:0002419)2.68653078
37Lactic acidosis (HP:0003128)2.68045351
38Myositis (HP:0100614)2.65411894
39Reticulocytopenia (HP:0001896)2.63316902
40Patellar aplasia (HP:0006443)2.62973607
41Methylmalonic aciduria (HP:0012120)2.62558680
42Myelodysplasia (HP:0002863)2.60474937
43Methylmalonic acidemia (HP:0002912)2.58318190
44Type I transferrin isoform profile (HP:0003642)2.57229150
45Abnormality of the labia minora (HP:0012880)2.56540239
46Optic disc pallor (HP:0000543)2.55259313
47Pancreatic fibrosis (HP:0100732)2.55153636
48Colon cancer (HP:0003003)2.51348683
49Pustule (HP:0200039)2.49873747
50Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.49697909
51Decreased activity of mitochondrial respiratory chain (HP:0008972)2.49697909
52Increased serum pyruvate (HP:0003542)2.49534080
53Poor head control (HP:0002421)2.47901807
54Impulsivity (HP:0100710)2.47850598
55Renal Fanconi syndrome (HP:0001994)2.47441160
56Rough bone trabeculation (HP:0100670)2.46881171
57Irregular epiphyses (HP:0010582)2.46613235
58Oral leukoplakia (HP:0002745)2.45900939
59Nephrogenic diabetes insipidus (HP:0009806)2.44809858
60Meckel diverticulum (HP:0002245)2.44313304
61Congenital primary aphakia (HP:0007707)2.43405270
62Retinal dysplasia (HP:0007973)2.42118190
63Bone marrow hypocellularity (HP:0005528)2.40159074
64True hermaphroditism (HP:0010459)2.39286594
65IgM deficiency (HP:0002850)2.39235477
66Abnormality of the preputium (HP:0100587)2.38826796
67Premature graying of hair (HP:0002216)2.36036465
68Abnormal protein glycosylation (HP:0012346)2.34509337
69Abnormal glycosylation (HP:0012345)2.34509337
70Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.34509337
71Abnormal protein N-linked glycosylation (HP:0012347)2.34509337
72Gait imbalance (HP:0002141)2.30988488
73Abnormality of the ileum (HP:0001549)2.29490335
74Pulmonary fibrosis (HP:0002206)2.29401071
75Aplastic anemia (HP:0001915)2.29084721
76Recurrent skin infections (HP:0001581)2.27805741
77Aplasia/Hypoplasia of the uvula (HP:0010293)2.26448663
78Respiratory failure (HP:0002878)2.26217478
79Hypothermia (HP:0002045)2.24433308
80Rhabdomyosarcoma (HP:0002859)2.21539780
81Lymphoma (HP:0002665)2.21029165
82Prostate neoplasm (HP:0100787)2.20902787
83Hypoplasia of the capital femoral epiphysis (HP:0003090)2.16770823
84Cleft eyelid (HP:0000625)2.16591145
85Abnormality of glycolysis (HP:0004366)2.14750763
86Gingivitis (HP:0000230)2.13118300
87Recurrent fungal infections (HP:0002841)2.12137209
88Nephronophthisis (HP:0000090)2.11892938
89Flat capital femoral epiphysis (HP:0003370)2.11415803
90Leukocytosis (HP:0001974)2.11074184
91Generalized aminoaciduria (HP:0002909)2.10381851
92Abnormality of aspartate family amino acid metabolism (HP:0010899)2.10190250
93Acute myeloid leukemia (HP:0004808)2.09533381
94Abnormal lung lobation (HP:0002101)2.08848989
95Recurrent pneumonia (HP:0006532)2.08425924
96Increased intramyocellular lipid droplets (HP:0012240)2.08306060
97CNS demyelination (HP:0007305)2.07736323
98Amaurosis fugax (HP:0100576)2.07150572
99Exercise intolerance (HP:0003546)2.06520833
100Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.06275929
101Tubulointerstitial nephritis (HP:0001970)2.06201669
102Reduced antithrombin III activity (HP:0001976)2.05820169
103Aplasia/Hypoplasia of the sacrum (HP:0008517)2.05236805
104Selective tooth agenesis (HP:0001592)2.05201972
105Recurrent viral infections (HP:0004429)2.02409338
106Ectopic kidney (HP:0000086)2.02144870
107Type II lissencephaly (HP:0007260)2.01882453
108Autoimmune thrombocytopenia (HP:0001973)2.01289422
109Stomatitis (HP:0010280)2.00466059
110Lethargy (HP:0001254)1.99607364
111Supernumerary spleens (HP:0009799)1.98453013
112Absent radius (HP:0003974)1.98395023
113Retrobulbar optic neuritis (HP:0100654)1.98172416
114Optic neuritis (HP:0100653)1.98172416
115Short tibia (HP:0005736)1.97957819
116Elevated erythrocyte sedimentation rate (HP:0003565)1.97562478
117Orchitis (HP:0100796)1.96475515
118Abnormal trabecular bone morphology (HP:0100671)1.96462034
119Premature ovarian failure (HP:0008209)1.95715722
120Abnormality of the prostate (HP:0008775)1.95483693
121Renal cortical cysts (HP:0000803)1.94961283
122Duodenal stenosis (HP:0100867)1.94263618
123Small intestinal stenosis (HP:0012848)1.94263618
124Abnormality of alanine metabolism (HP:0010916)1.93039859
125Hyperalaninemia (HP:0003348)1.93039859
126Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.93039859
127IgG deficiency (HP:0004315)1.91415148
128Atrophy/Degeneration involving motor neurons (HP:0007373)1.90206669
129Spinal muscular atrophy (HP:0007269)1.89834740
130Median cleft lip (HP:0000161)1.89818866
131Abnormal number of erythroid precursors (HP:0012131)1.88534559
132Genital tract atresia (HP:0001827)1.88210974
133Clubbing of toes (HP:0100760)1.86719891
134Abnormality of cells of the erythroid lineage (HP:0012130)1.86233924
135Microretrognathia (HP:0000308)1.85403270
136Eosinophilia (HP:0001880)1.85203270
137Aplasia/Hypoplasia of the tongue (HP:0010295)1.85064471
13811 pairs of ribs (HP:0000878)1.85011848
139Absent epiphyses (HP:0010577)1.84865365
140Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.84865365
141Horseshoe kidney (HP:0000085)1.84685790
142Cerebral hypomyelination (HP:0006808)1.83696512
143Hematochezia (HP:0002573)1.83685902
144Aseptic necrosis (HP:0010885)1.83539695
145Personality changes (HP:0000751)1.82866674
146Absent thumb (HP:0009777)1.82453772
147Basal ganglia calcification (HP:0002135)1.81687773
148Abnormality of the renal cortex (HP:0011035)1.81680912
149Vasculitis (HP:0002633)1.80334703
150Congenital stationary night blindness (HP:0007642)1.80138128
151Abnormal number of incisors (HP:0011064)1.80096982
152Increased neuronal autofluorescent lipopigment (HP:0002074)1.79945465
153Secondary amenorrhea (HP:0000869)1.79183794
154Hypomagnesemia (HP:0002917)1.79136527
155Hyperglycinemia (HP:0002154)1.78876006
156Abnormality of cells of the lymphoid lineage (HP:0012140)1.77642406
157Lymphopenia (HP:0001888)1.77330726
158Absent forearm bone (HP:0003953)1.76982426
159Aplasia involving forearm bones (HP:0009822)1.76982426
160Aplasia/Hypoplasia of the tibia (HP:0005772)1.76899933
161Intestinal atresia (HP:0011100)1.76708813
162CNS hypomyelination (HP:0003429)1.76587537
163Exercise-induced muscle cramps (HP:0003710)1.76398222
164Abnormal hair whorl (HP:0010721)1.76157101
165Leukopenia (HP:0001882)1.76073839
166Small epiphyses (HP:0010585)1.75880159
167Abnormality of eosinophils (HP:0001879)1.75475749
168Medulloblastoma (HP:0002885)1.75153366
169Abnormality of methionine metabolism (HP:0010901)1.74900335
170Vaginal atresia (HP:0000148)1.74519273
171Cellular immunodeficiency (HP:0005374)1.73635621
172Abnormality of serum amino acid levels (HP:0003112)1.73502019
173Interstitial pulmonary disease (HP:0006530)1.73363058
174Abnormality of T cell number (HP:0011839)1.73333269
175Type 2 muscle fiber atrophy (HP:0003554)1.72403040
176Delayed gross motor development (HP:0002194)1.71693519
177Gonadotropin excess (HP:0000837)1.71659047
178Abnormality of the renal medulla (HP:0100957)1.71547121
179B lymphocytopenia (HP:0010976)1.71288219
180Abnormality of the duodenum (HP:0002246)1.70199860
181Sloping forehead (HP:0000340)1.70084612
182Leukodystrophy (HP:0002415)1.69647441
183Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.68429006
184Metaphyseal dysplasia (HP:0100255)1.67645242
185Postnatal microcephaly (HP:0005484)1.67425253
186Exertional dyspnea (HP:0002875)1.67361310
187Stenosis of the external auditory canal (HP:0000402)1.67358971
188Abnormal rod and cone electroretinograms (HP:0008323)1.66576173

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB13.60714203
2EIF2AK13.38505309
3WEE12.90585435
4PLK42.85351583
5TRIM282.81416279
6BCR2.75576511
7CDC72.73505212
8MAP4K22.43672936
9EIF2AK32.35038593
10ACVR1B2.22423375
11STK102.19156027
12IRAK42.18949535
13NEK22.14103867
14SRPK12.12790787
15IRAK31.95673927
16RPS6KA41.94621102
17MAP3K121.89375144
18PDK21.88875552
19CSNK1G11.83313890
20BRSK21.81314461
21TSSK61.81287171
22PLK11.80460430
23MKNK11.74256249
24TTK1.71254566
25EIF2AK21.70894329
26MAP3K141.68001820
27CDK191.65382766
28PBK1.63713263
29VRK11.59724837
30PLK31.50958070
31BLK1.46024428
32CDK121.42001032
33NME11.40844012
34WNK31.40576227
35CDK31.40315822
36TYK21.39942127
37NME21.39603611
38JAK31.38827687
39CHEK21.36066230
40IKBKB1.35084802
41VRK21.33796681
42TEC1.33600342
43MAP3K81.30493632
44MKNK21.30092406
45TGFBR11.29695629
46AURKB1.27323391
47STK161.27091183
48MST41.23241778
49CDK71.22305193
50ATR1.21965867
51CSNK1G31.20376788
52PASK1.14277186
53NEK91.11689070
54MAP4K11.11128150
55PIM11.10745783
56NEK11.09659743
57CSNK1G21.08927142
58CDK81.07470386
59MAPK131.07372597
60TLK11.06015590
61ADRBK21.04394181
62PNCK1.04175879
63STK41.03730993
64ZAK1.03374581
65CCNB11.02408948
66MELK1.02005267
67PINK11.00805311
68DYRK20.98108936
69AURKA0.97145351
70TBK10.96035492
71EPHA20.94317245
72RIPK40.94257085
73MAP2K70.91672184
74CHUK0.91667141
75ERBB30.91039253
76BMPR1B0.90822894
77TXK0.88475288
78CSNK1A1L0.88169164
79GRK10.85410558
80MAP3K30.83196816
81SIK30.83040768
82NUAK10.82875190
83EPHA30.82675865
84BTK0.82126667
85PAK40.80829077
86BCKDK0.78469560
87BMPR20.77954027
88CDK40.77830887
89IKBKE0.77698421
90CSF1R0.77075679
91CHEK10.76360291
92MAP3K40.75367742
93SCYL20.74161677
94PIM20.73978638
95TESK20.72836947
96ZAP700.72148996
97STK30.71771103
98LRRK20.71759701
99TAOK30.70091185
100CDK60.69075823
101DYRK30.68984973
102KIT0.66845186
103MOS0.65550254
104OBSCN0.64931917
105BRAF0.64326778
106ATM0.62453080
107MINK10.62329770
108RPS6KB20.62321817
109OXSR10.61676520
110BRSK10.61445728
111CSNK2A10.61344169
112NLK0.57668459
113KDR0.56615525
114ABL20.53665019
115MARK30.52356236
116MAPKAPK30.52112916
117TRPM70.51150428
118SGK20.51058499
119LYN0.50831021
120CDK20.50329972
121PLK20.49800306
122RPS6KA50.49420223
123STK38L0.48671706
124MAP2K30.47758985
125DYRK1A0.47720845
126PRKCE0.47379659
127FLT30.46807527
128STK390.46742847
129DMPK0.45750661
130CSNK2A20.45245815
131MAP3K50.45087987
132RAF10.45025888
133JAK10.44727712
134FER0.44620801
135FRK0.44282257
136PIK3CG0.43435313
137CLK10.43274534
138MAPKAPK20.41584273
139PAK10.39891287
140PRKCQ0.39709414
141IRAK10.38268994
142CSNK1A10.36676671
143PIK3CA0.36244324
144LIMK10.34615533
145CASK0.27452013
146MAP2K40.26864869
147PRKCG0.26690211
148MUSK0.26276188
149WNK40.25410864
150TIE10.24771757
151CDK140.24572518
152TNIK0.24339007

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030303.54910294
2Oxidative phosphorylation_Homo sapiens_hsa001903.32937344
3Proteasome_Homo sapiens_hsa030503.13486332
4Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.10131847
5Mismatch repair_Homo sapiens_hsa034303.05878480
6Parkinsons disease_Homo sapiens_hsa050122.97666390
7RNA polymerase_Homo sapiens_hsa030202.80582186
8Homologous recombination_Homo sapiens_hsa034402.75392477
9RNA transport_Homo sapiens_hsa030132.55741222
10Cell cycle_Homo sapiens_hsa041102.50054837
11Ribosome_Homo sapiens_hsa030102.40123924
12Spliceosome_Homo sapiens_hsa030402.33299502
13Base excision repair_Homo sapiens_hsa034102.31806178
14Propanoate metabolism_Homo sapiens_hsa006402.16952009
15Basal transcription factors_Homo sapiens_hsa030222.13756137
16Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.11727606
17Non-homologous end-joining_Homo sapiens_hsa034502.11658958
18Nucleotide excision repair_Homo sapiens_hsa034202.10275706
19Huntingtons disease_Homo sapiens_hsa050162.06332573
20Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.99840242
21Fatty acid elongation_Homo sapiens_hsa000621.96065492
22RNA degradation_Homo sapiens_hsa030181.94841961
23Fanconi anemia pathway_Homo sapiens_hsa034601.91652118
24Pyrimidine metabolism_Homo sapiens_hsa002401.81365693
25Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.81233032
26One carbon pool by folate_Homo sapiens_hsa006701.76516381
27Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.74396294
28p53 signaling pathway_Homo sapiens_hsa041151.70116747
29Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.59536507
30Alzheimers disease_Homo sapiens_hsa050101.57009078
31Legionellosis_Homo sapiens_hsa051341.56653784
32NF-kappa B signaling pathway_Homo sapiens_hsa040641.55326561
33Herpes simplex infection_Homo sapiens_hsa051681.53996031
34Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.46647043
35Epstein-Barr virus infection_Homo sapiens_hsa051691.44767451
36Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.44447828
37Leishmaniasis_Homo sapiens_hsa051401.44248928
38Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.44070762
39Protein export_Homo sapiens_hsa030601.42834839
40Butanoate metabolism_Homo sapiens_hsa006501.39303536
41Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.39057433
42Collecting duct acid secretion_Homo sapiens_hsa049661.38060233
43Antigen processing and presentation_Homo sapiens_hsa046121.36101264
44NOD-like receptor signaling pathway_Homo sapiens_hsa046211.36066219
45Phototransduction_Homo sapiens_hsa047441.32060884
46Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.23706165
47Measles_Homo sapiens_hsa051621.18835279
48mRNA surveillance pathway_Homo sapiens_hsa030151.17993067
492-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.17440130
50Pyruvate metabolism_Homo sapiens_hsa006201.16169532
51Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.13073679
52Allograft rejection_Homo sapiens_hsa053301.12493144
53Graft-versus-host disease_Homo sapiens_hsa053321.10879121
54Steroid biosynthesis_Homo sapiens_hsa001001.09892725
55Intestinal immune network for IgA production_Homo sapiens_hsa046721.08267551
56Peroxisome_Homo sapiens_hsa041461.06774474
57Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.06093686
58Asthma_Homo sapiens_hsa053101.00521819
59Selenocompound metabolism_Homo sapiens_hsa004500.99981124
60Hematopoietic cell lineage_Homo sapiens_hsa046400.99293928
61Apoptosis_Homo sapiens_hsa042100.98857177
62Purine metabolism_Homo sapiens_hsa002300.98667023
63Viral carcinogenesis_Homo sapiens_hsa052030.97519833
64Cardiac muscle contraction_Homo sapiens_hsa042600.97385525
65Influenza A_Homo sapiens_hsa051640.96496620
66Toll-like receptor signaling pathway_Homo sapiens_hsa046200.93231220
67Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.92060134
68Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.90149646
69RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.89988424
70Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.88956699
71Tuberculosis_Homo sapiens_hsa051520.88821377
72Systemic lupus erythematosus_Homo sapiens_hsa053220.86342903
73Malaria_Homo sapiens_hsa051440.86221442
74Tryptophan metabolism_Homo sapiens_hsa003800.85497215
75Rheumatoid arthritis_Homo sapiens_hsa053230.84107074
76Other glycan degradation_Homo sapiens_hsa005110.81429103
77Shigellosis_Homo sapiens_hsa051310.81178622
78beta-Alanine metabolism_Homo sapiens_hsa004100.77606899
79Osteoclast differentiation_Homo sapiens_hsa043800.77384708
80HTLV-I infection_Homo sapiens_hsa051660.76710078
81Vitamin B6 metabolism_Homo sapiens_hsa007500.75827701
82TNF signaling pathway_Homo sapiens_hsa046680.75369791
83Primary immunodeficiency_Homo sapiens_hsa053400.74737789
84Phagosome_Homo sapiens_hsa041450.74237762
85Hepatitis B_Homo sapiens_hsa051610.73871950
86Type I diabetes mellitus_Homo sapiens_hsa049400.71419001
87Metabolic pathways_Homo sapiens_hsa011000.71269597
88Fatty acid metabolism_Homo sapiens_hsa012120.70688802
89Transcriptional misregulation in cancer_Homo sapiens_hsa052020.70249937
90Pentose phosphate pathway_Homo sapiens_hsa000300.70234271
91Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.69984316
92Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.69284902
93Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.68838163
94Primary bile acid biosynthesis_Homo sapiens_hsa001200.67544626
95Folate biosynthesis_Homo sapiens_hsa007900.67447272
96Carbon metabolism_Homo sapiens_hsa012000.66351843
97Pertussis_Homo sapiens_hsa051330.65036556
98Staphylococcus aureus infection_Homo sapiens_hsa051500.64977422
99Jak-STAT signaling pathway_Homo sapiens_hsa046300.63322380
100Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.63050854
101Oocyte meiosis_Homo sapiens_hsa041140.62577847
102Glutathione metabolism_Homo sapiens_hsa004800.61273500
103Lysosome_Homo sapiens_hsa041420.60928599
104Circadian rhythm_Homo sapiens_hsa047100.60250369
105MicroRNAs in cancer_Homo sapiens_hsa052060.57411508
106Sulfur metabolism_Homo sapiens_hsa009200.57394998
107Small cell lung cancer_Homo sapiens_hsa052220.56572046
108Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.56046219
109Toxoplasmosis_Homo sapiens_hsa051450.55250793
110Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.54446376
111Caffeine metabolism_Homo sapiens_hsa002320.52553132
112Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.52260334
113B cell receptor signaling pathway_Homo sapiens_hsa046620.51706173
114TGF-beta signaling pathway_Homo sapiens_hsa043500.50206738
115Vibrio cholerae infection_Homo sapiens_hsa051100.46747067
116Viral myocarditis_Homo sapiens_hsa054160.46701479
117Thyroid cancer_Homo sapiens_hsa052160.42995336
118Leukocyte transendothelial migration_Homo sapiens_hsa046700.42770851
119Drug metabolism - other enzymes_Homo sapiens_hsa009830.42023789
120Autoimmune thyroid disease_Homo sapiens_hsa053200.41242322
121Salmonella infection_Homo sapiens_hsa051320.41228260
122Maturity onset diabetes of the young_Homo sapiens_hsa049500.41162268
123Fatty acid degradation_Homo sapiens_hsa000710.39615574
124Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.38775314
125Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.38521685
126Pancreatic cancer_Homo sapiens_hsa052120.38164140
127Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.37855676
128Renin-angiotensin system_Homo sapiens_hsa046140.37272620
129Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.37008949
130Sphingolipid metabolism_Homo sapiens_hsa006000.36872975
131Biosynthesis of amino acids_Homo sapiens_hsa012300.36733279
132Olfactory transduction_Homo sapiens_hsa047400.36407421
133Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.35325712
134Nitrogen metabolism_Homo sapiens_hsa009100.34877979
135HIF-1 signaling pathway_Homo sapiens_hsa040660.34868512
136Chemical carcinogenesis_Homo sapiens_hsa052040.33766840
137Notch signaling pathway_Homo sapiens_hsa043300.33403053
138African trypanosomiasis_Homo sapiens_hsa051430.32564922
139Ether lipid metabolism_Homo sapiens_hsa005650.30412598
140Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.30021266
141Cysteine and methionine metabolism_Homo sapiens_hsa002700.28898014
142Arachidonic acid metabolism_Homo sapiens_hsa005900.28893050
143Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.28441453
144Chemokine signaling pathway_Homo sapiens_hsa040620.28366141
145Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.28228095
146Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.28169889
147SNARE interactions in vesicular transport_Homo sapiens_hsa041300.27775954
148Hepatitis C_Homo sapiens_hsa051600.27074432
149Arginine and proline metabolism_Homo sapiens_hsa003300.26300170
150Regulation of autophagy_Homo sapiens_hsa041400.25808684
151Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.25650282
152FoxO signaling pathway_Homo sapiens_hsa040680.25556072
153Pentose and glucuronate interconversions_Homo sapiens_hsa000400.25123081
154Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.24100462
155Retinol metabolism_Homo sapiens_hsa008300.23588005
156Steroid hormone biosynthesis_Homo sapiens_hsa001400.22054250
157Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.19890857
158Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.18929885
159N-Glycan biosynthesis_Homo sapiens_hsa005100.18193347

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